CN106109905A - A kind of Chinese medicine composition of lactogenic - Google Patents
A kind of Chinese medicine composition of lactogenic Download PDFInfo
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- CN106109905A CN106109905A CN201610769329.3A CN201610769329A CN106109905A CN 106109905 A CN106109905 A CN 106109905A CN 201610769329 A CN201610769329 A CN 201610769329A CN 106109905 A CN106109905 A CN 106109905A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
Abstract
The present invention relates to the Chinese medicine composition of a kind of lactogenic, Radix Rhapontici, Caulis Clematidis Armandii, Radix Ophiopogonis, Semen Vaccariae, Radix Angelicae Sinensis, Poria, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Radix Glycyrrhizae have been prepared from.This Chinese medicine composition has benefiting qi and nourishing blood, the effect of stimulating milk secretion of stimulating the menstrual flow, and few to breast in puerperal, agalactia has significant curative effect, its reasonable recipe, determined curative effect, low cost, can promote the galactopoiesis of sow in puerperal, and then improve the survival rate of piglet.
Description
Technical field
The invention belongs to herbal medicine technical field, particularly to the Chinese medicine composition of a kind of lactogenic.
Background technology
In husbandry sector, along with the raising of Swine Production level, the expansion of scale, the reinforcement of people's health care consciousness, spy
It not that the attention to sow is more and more higher.Sow agalactia syndrome, is one of the regular incidence in sow puerperal, it is characterized in that sow
Hypogalactia or agalactia is gradually showed in 15 days puerperal, anorexia, constipation, indifferent etc. to piglet.Piglet can not get the breast milk of abundance and becomes
Obtaining thin and weak, susceptible disease, mortality rate is high, causes serious loss to raiser.It is total that the morbidity number of elements of sow puerperal hypogalactia accounts for product pig
The 22.2% of number, and on the rise.Therefore, prevent and treat puerperal hypogalactia and seem the most urgent.
Can sow milk yield height be to be related to piglet survival ratio and cultivate the key issue of healthy and strong piglet, it is necessary to causes
The attention of raiser.In present pig industry, the reason causing sow puerperal hypogalactia or agalactia is a lot, such as sow malnutrition,
Crossing thin, weak asthenia, physiological function goes down；Sow overfertilization, breast is filled by fat；Insemination of sows is too early, and development of breast is the most complete；
Sow suffers from mastitis, endometritis etc. puerperal.
At present, the primary treatments for sow hypogalactia is hormonotherapy, i.e. intramuscular injection diethylstilbestrol.Or muscle note
Penetrate oxytocin.Though the method instant effect, index is not effected a permanent cure, and damage bigger for sow body and reproductive function.And
Chinese veterinary pharmacopoeia version had been included in 2010 lactogenesis dissipate, lactogenesis dissipate, stimulate the secretion of milk spirit dissipate three kinds of Chinese powder medicines, all there is stimulating milk secretion of stimulating the menstrual flow
Effect, but DeGrain is the most invalid in actual applications.
Therefore, a kind of tcm product that can effectively treat sow hypogalactia is developed so that it is reach treating both the principal and secondary aspects of a disease, nontoxic, nothing
Do harm to, have no side effect, the requirement of environmental protection, have great importance.
Summary of the invention
The present invention passes through deeply, earnest experiments, successfully have developed the Chinese medicine composition of a kind of lactogenic, and proves with experiment
Its curative effect.The Chinese medicine composition of the present invention has benefiting qi and nourishing blood, the effect of stimulating milk secretion of stimulating the menstrual flow, and the hypogalactia that can effectively solve sow is asked
Topic.Noresidue of the present invention, have no adverse effects, the sow in puerperal of agalactia, hypogalactia is had good result.
The Chinese medicine composition of a kind of lactogenic, described compositions comprises following component: Radix Rhapontici, Caulis Clematidis Armandii, Radix Ophiopogonis, Wang Buliu
Row, Radix Angelicae Sinensis, Poria, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Radix Glycyrrhizae.
The each constituent of described compositions is calculated by weight as: Radix Rhapontici 1～4 parts, Caulis Clematidis Armandii 0.5～2 parts, Radix Ophiopogonis 1～4
Part, Semen Vaccariae 1～10 parts, Radix Angelicae Sinensis 0.5～2 parts, Poria 1～4 parts, Radix Rehmanniae Preparata 1～4 parts, the Radix Paeoniae Alba 1～4 parts, Rhizoma Chuanxiong 0.5～2
Part, Radix Glycyrrhizae 1～3 parts.
The each constituent of described compositions is counted most preferably by weight: Radix Rhapontici 3 parts, Caulis Clematidis Armandii 1.5 parts, Radix Ophiopogonis 3 parts, king
Do not stay row 6 parts, Radix Angelicae Sinensis 1.5 parts, 3 parts of Poria, Radix Rehmanniae Preparata 3 parts, the Radix Paeoniae Alba 3 parts, Rhizoma Chuanxiong 1.5 parts, 1 part of Radix Glycyrrhizae.
This Chinese medicine composition is the various conventional Chinese medicine preparation form containing or not contain pharmaceutic adjuvant.
Described compositions can be prepared as being suitable for the various dosage forms that pig uses, including oral liquid, powder, granule.
The Chinese medicine composition of a kind of lactogenic of the present invention is theoretical as foundation with Chinese veterinarian, we reuse Radix Rhapontici, Caulis Clematidis Armandii,
The dredging collateral such as Semen Vaccariae, invigorate blood circulation, stimulating milk secretion is principal agent, be equipped with Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Rhizoma Chuanxiong etc. and enrich blood, nourish blood as accessory drugs.Full side is mutually
Compatibility plays benefiting qi and nourishing blood altogether, the effect of stimulating milk secretion of stimulating the menstrual flow, for puerperal breast few, agalactia.
The invention has the beneficial effects as follows:
1, the pharmaceutical composition of the present invention is natural pure Chinese medicinal preparation, and former medicine is easy to get, with low cost；
2, this prescription follows theory and the principle of medication of Chinese veterinarian, has no adverse reaction and toxic and side effects, and safety coefficient is high, treats
Effect is definite.
3, the Chinese medicine composition of the present invention, is accustomed to according to swine rearing, can be made into oral liquid, granule, powder for spice
Use.
4, preparation is simple for the present invention, it is simple to operation.
Detailed description of the invention
With the following Examples it is observed that the beneficial property of the present invention, these embodiments are illustrative, will not be right
The present invention is construed as limiting.
The preparation of embodiment 1 lactogenic mixture (oral liquid)
1. formula composition: Radix Rhapontici 2 parts (2000g), Caulis Clematidis Armandii 1 part (1000g), Radix Ophiopogonis 3 parts (3000g), Semen Vaccariae 3 parts
(3000g), Radix Angelicae Sinensis 2 parts (2000g), 3 parts of Poria (3000g), Radix Rehmanniae Preparata 3 parts (3000g), the Radix Paeoniae Alba 3 parts (1000g), Rhizoma Chuanxiong 1 part
(1000g), 1 part of Radix Glycyrrhizae (1000g).
2. it is prepared as oral liquid: first weighed by formula by Chinese medicine composition, adds 10 times amount water soaking 1 hour, decoct two
Secondary, 2 hours for the first time, second time decoction 1.5 hours, keep slight boiling condition after boiling every time, after twice liquid medicine mixing merges filtration,
It is 1g/ml (every ml solution raw medicinal herbs Han 1g) that concentrating under reduced pressure is recycled to solution concentration, cold preservation 24 hours, and pulp board is supplied after filtering
Loss amount, then cold preservation 24 hours, after filtration, flowing steam sterilization 30 minutes；Let cool rear medicinal liquid add 3 ‰ amounts sodium benzoate with
Potassium sorbate, mixing, fill, to obtain final product.
The preparation of embodiment 2 lactogenic powder
1. formula composition: Radix Rhapontici 3 parts (3000g), Caulis Clematidis Armandii 0.5 part (500g), 1 part of (1000g), Semen Vaccariae 1 of Radix Ophiopogonis
Part (1000g), Radix Angelicae Sinensis 1 part (1000g), 2 parts of Poria (2000g), Radix Rehmanniae Preparata 1 part (1000g), the Radix Paeoniae Alba 3 parts of (2000g), Rhizoma Chuanxiongs
0.5 part (500g), 2 parts of Radix Glycyrrhizae (2000g).
2. it is prepared as powder: first weighed by formula by Chinese medicine composition, pulverizes respectively, excessively 40 mesh sieves, mix homogeneously, i.e.
?.
The preparation of embodiment 3 CuiRu KeLi
1. formula composition: Radix Rhapontici 1 part (1000g), Caulis Clematidis Armandii 2 parts (2000g), Radix Ophiopogonis 3 parts (3000g), Semen Vaccariae 5 parts
(5000g), Radix Angelicae Sinensis 0.5 part (500g), 1 part of Poria (1000g), Radix Rehmanniae Preparata 3 parts (3000g), the Radix Paeoniae Alba 3 parts of (3000g), Rhizoma Chuanxiongs 2
Part (2000g), 3 parts of Radix Glycyrrhizae (3000g).
2. it is prepared as uterus perfusion: first weighed by formula by Chinese medicine composition, adds 10 times amount water soaking 1 hour, decoct
Boiling twice, 2 hours for the first time, second time decocted 1.5 hours, kept slight boiling condition after boiling every time, and twice liquid medicine mixing merged
After filter, concentrating under reduced pressure is recycled to the thick paste that relative density is 1.21～1.25 (55 DEG C), adds 1 part of sugar and 3 parts of dextrin, makes
Granule, is dried, subpackage, to obtain final product.
Embodiment 4, the Chinese medicine composition clinical trial to hypogalactia sow of a kind of lactogenic
1 materials and methods
1.1 test material
1.1.1 the Chinese medicine composition of lactogenic is provided by Tianjin Ringpu Bio-technology Co., Ltd..
1.1.2 subjects and screening criteria:
On pig farm, Tangshan, select body condition identical concentrate on interior normal labor in one week, parity is identical, date of parturition is close,
The sow that litter size is same or like.
Judge disease criterion: piglet head black oil mark；Piglet mouth, buccal have bites the wound stung；Most piglet knee joints close
Joint has damage；Sow is put milk and terminates, and piglet also contains sow nipple and do not puts；" breast circle " is had on sow breast；Sow hides milk；Sow
Anorexia, constipation, indifferent etc. to piglet；If any both the above or two or more phenomenon, then it is judged to sow hypogalactia.
1.1.3 feedstuff, raising apparatus and other articles for use are provided by pig farm.
1.1.4 record articles for use and relevant test articles for use, provided by seminar.
1.2 test method
Test sow is randomly divided into 4 groups, often 12 sows of group.Experimental group 1 is low dosage administration group, and sow takes every day
Embodiment 2 product, admixes this product 90g in every feedstuff；Experimental group 2 is clinical recommended dose administration group, and sow takes every day
Embodiment 2 product, admixes this product 180g in every feedstuff；Respectively it is used in conjunction 5d；3rd group is that matched group is injected in oxytocin, purchased from deep
Ditch between fields producer；4th group is the positive controls that morbidity is not administered.
1.3 efficacy determinations: showing hypogalactia phenomenon in taking medicine 5 and improve substantially, it is effective that lactation amount can reach normal level,
It is otherwise invalid.
1.4 rearing conditions: test group sow all use identical trophic level, unified management system, unified raising program,
Unified feeding environment, and carry out routinely preventing disinfection.
2 results and analysis
The Chinese medicine composition of table 1 lactogenic is to hypogalactia sow therapeutic effect
As seen from the above table: the product treatment sow hypogalactia in embodiment, there is positive effect.Group 2 each takes 180g, is used in conjunction
5d, therapeutic effect is best.
3. brief summary and discussion
Result shows, Chinese medicine composition can effectively treat sow hypogalactia.Postpartum agalorrhea, the sow of hypogalactia, in using
Taking product of the present invention, a 180g, be used in conjunction 5d, effective percentage reaches 91.7%, shows that the present invention treats sow hypogalactia and has reliable curative effect.
Claims (5)
1. the Chinese medicine composition of a lactogenic, it is characterised in that: described compositions comprises following component: Radix Rhapontici, Caulis Clematidis Armandii, wheat
Winter, Semen Vaccariae, Radix Angelicae Sinensis, Poria, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Radix Glycyrrhizae.
The Chinese medicine composition of a kind of lactogenic the most according to claim 1, it is characterised in that: each constituent of described compositions
Be calculated by weight as: Radix Rhapontici 1～4 parts, Caulis Clematidis Armandii 0.5～2 parts, Radix Ophiopogonis 1～4 parts, Semen Vaccariae 1～10 parts, Radix Angelicae Sinensis 0.5～
2 parts, Poria 1～4 parts, Radix Rehmanniae Preparata 1～4 parts, the Radix Paeoniae Alba 1～4 parts, Rhizoma Chuanxiong 0.5～2 parts, Radix Glycyrrhizae 1～3 parts.
The Chinese medicine composition of a kind of lactogenic the most according to claim 1, it is characterised in that: each constituent of described compositions
Count most preferably by weight: Radix Rhapontici 3 parts, Caulis Clematidis Armandii 1.5 parts, Radix Ophiopogonis 3 parts, Semen Vaccariae 6 parts, Radix Angelicae Sinensis 1.5 parts, 3 parts of Poria,
Radix Rehmanniae Preparata 3 parts, the Radix Paeoniae Alba 3 parts, Rhizoma Chuanxiong 1.5 parts, 1 part of Radix Glycyrrhizae.
The Chinese medicine composition of a kind of lactogenic the most according to claim 1, it is characterised in that: this Chinese medicine composition be containing or
Do not contain the various conventional Chinese medicine preparation form of pharmaceutic adjuvant.
The Chinese medicine composition of a kind of lactogenic the most according to claim 1, it is characterised in that: described compositions can be prepared as
It is suitable for the various dosage forms that pig uses, including oral liquid, powder, granule.
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| CN201610769329.3A CN106109905A (en) | 2016-08-30 | 2016-08-30 | A kind of Chinese medicine composition of lactogenic |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610769329.3A CN106109905A (en) | 2016-08-30 | 2016-08-30 | A kind of Chinese medicine composition of lactogenic |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106578517A (en) * | 2016-12-09 | 2017-04-26 | 刘志远 | Foodstuff for increasing milk yield of suckling pigs and preparation method of foodstuff |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102048841A (en) * | 2009-11-10 | 2011-05-11 | 天津天士力制药股份有限公司 | Lactogenic traditional Chinese medicine composition and preparation method thereof |
| CN103830502A (en) * | 2014-03-26 | 2014-06-04 | 蚌埠火鹤制药有限公司 | Traditional Chinese medicine composition for lactagogue |
-
2016
- 2016-08-30 CN CN201610769329.3A patent/CN106109905A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102048841A (en) * | 2009-11-10 | 2011-05-11 | 天津天士力制药股份有限公司 | Lactogenic traditional Chinese medicine composition and preparation method thereof |
| CN103830502A (en) * | 2014-03-26 | 2014-06-04 | 蚌埠火鹤制药有限公司 | Traditional Chinese medicine composition for lactagogue |
Non-Patent Citations (2)
| Title |
|---|
| 李继广等: "《产后缺乳的中医治疗动物实验研究》", 31 December 2004 * |
| 谭增子等: "《中药"泌乳灵"的催乳效果观察》", 31 December 1998 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106578517A (en) * | 2016-12-09 | 2017-04-26 | 刘志远 | Foodstuff for increasing milk yield of suckling pigs and preparation method of foodstuff |
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Application publication date: 20161116 |