CN111253491A - 一种用于分离临床样本中的糖基化外泌体的凝集素-磁性载体偶联复合物 - Google Patents
一种用于分离临床样本中的糖基化外泌体的凝集素-磁性载体偶联复合物 Download PDFInfo
- Publication number
- CN111253491A CN111253491A CN202010060055.7A CN202010060055A CN111253491A CN 111253491 A CN111253491 A CN 111253491A CN 202010060055 A CN202010060055 A CN 202010060055A CN 111253491 A CN111253491 A CN 111253491A
- Authority
- CN
- China
- Prior art keywords
- lectin
- magnetic carrier
- exosomes
- exosome
- agglutinin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/10—Peptides being immobilised on, or in, an organic carrier the carrier being a carbohydrate
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
- B01J20/28009—Magnetic properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
- B01J20/28004—Sorbent size or size distribution, e.g. particle size
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
- B01J20/28016—Particle form
- B01J20/28019—Spherical, ellipsoidal or cylindrical
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
- B01J20/282—Porous sorbents
- B01J20/285—Porous sorbents based on polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3206—Organic carriers, supports or substrates
- B01J20/3208—Polymeric carriers, supports or substrates
- B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
- B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/34—Regenerating or reactivating
- B01J20/3425—Regenerating or reactivating of sorbents or filter aids comprising organic materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/34—Regenerating or reactivating
- B01J20/345—Regenerating or reactivating using a particular desorbing compound or mixture
- B01J20/3475—Regenerating or reactivating using a particular desorbing compound or mixture in the liquid phase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
- C07K14/42—Lectins, e.g. concanavalin, phytohaemagglutinin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/405—Concentrating samples by adsorption or absorption
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Botany (AREA)
- Inorganic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims (13)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010060055.7A CN111253491B (zh) | 2020-01-19 | 2020-01-19 | 一种用于分离临床样本中的糖基化外泌体的凝集素-磁性载体偶联复合物 |
CN202210166146.8A CN114813264A (zh) | 2020-01-19 | 2020-01-19 | 凝集素-磁性载体偶联复合物用于分离糖基化外泌体的应用 |
JP2022543156A JP7383162B2 (ja) | 2020-01-19 | 2021-01-05 | 臨床サンプルからグリコシル化エクソソームを分離することに用いられるレクチン-磁性担体カップリング複合体 |
PCT/CN2021/070288 WO2021143576A1 (zh) | 2020-01-19 | 2021-01-05 | 一种用于分离临床样本中的糖基化外泌体的凝集素-磁性载体偶联复合物 |
EP21741624.7A EP4092052A4 (en) | 2020-01-19 | 2021-01-05 | CONJUGATED LECTIN-MAGNETIC SUPPORT COMPLEX FOR THE ISOLATION OF GLYCOSYLATED EXOSOMES FROM CLINICAL SPECIMENS |
US17/864,352 US20220372173A1 (en) | 2020-01-19 | 2022-07-13 | Lectin-magnetic carrier coupling complex for separating glycosylated exosomes from clinical sample |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010060055.7A CN111253491B (zh) | 2020-01-19 | 2020-01-19 | 一种用于分离临床样本中的糖基化外泌体的凝集素-磁性载体偶联复合物 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202210166146.8A Division CN114813264A (zh) | 2020-01-19 | 2020-01-19 | 凝集素-磁性载体偶联复合物用于分离糖基化外泌体的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN111253491A true CN111253491A (zh) | 2020-06-09 |
CN111253491B CN111253491B (zh) | 2022-03-25 |
Family
ID=70944091
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010060055.7A Active CN111253491B (zh) | 2020-01-19 | 2020-01-19 | 一种用于分离临床样本中的糖基化外泌体的凝集素-磁性载体偶联复合物 |
CN202210166146.8A Pending CN114813264A (zh) | 2020-01-19 | 2020-01-19 | 凝集素-磁性载体偶联复合物用于分离糖基化外泌体的应用 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202210166146.8A Pending CN114813264A (zh) | 2020-01-19 | 2020-01-19 | 凝集素-磁性载体偶联复合物用于分离糖基化外泌体的应用 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20220372173A1 (zh) |
EP (1) | EP4092052A4 (zh) |
JP (1) | JP7383162B2 (zh) |
CN (2) | CN111253491B (zh) |
WO (1) | WO2021143576A1 (zh) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021143576A1 (zh) * | 2020-01-19 | 2021-07-22 | 北京热景生物技术股份有限公司 | 一种用于分离临床样本中的糖基化外泌体的凝集素-磁性载体偶联复合物 |
CN113652388A (zh) * | 2021-09-02 | 2021-11-16 | 西安龙旂生物科技有限公司 | 一种高纯度外泌体提取试剂盒及其提取方法 |
CN114354913A (zh) * | 2021-12-31 | 2022-04-15 | 厦门大学 | 一种外泌体pd-l1糖基化检测方法 |
CN114540491A (zh) * | 2021-12-08 | 2022-05-27 | 北京尧景基因技术有限公司 | 一种基于岩藻糖基化细胞外囊泡中差异化表达miRNA的肝癌预测模型建立及应用 |
CN115786266A (zh) * | 2023-01-31 | 2023-03-14 | 山东康华生物医疗科技股份有限公司 | 一种凝集素微阵列芯片的制备方法及捕获细胞外泌体的方法 |
CN118150843A (zh) * | 2024-04-01 | 2024-06-07 | 北京热景生物技术股份有限公司 | 一种阿尔兹海默症检测标志物糖链外泌体P-Tau-217及其应用 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112877274B (zh) * | 2021-01-29 | 2024-02-09 | 南京大学 | 一种细胞外囊泡磁性印迹材料及其制备方法与应用 |
CN113671185A (zh) * | 2021-08-23 | 2021-11-19 | 安龄(上海)生物科技有限公司 | 一种外泌体识别装置及方法 |
WO2023165529A1 (zh) * | 2022-03-01 | 2023-09-07 | 南京羿检医学科技有限公司 | 检测迁移体的方法和系统 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170014450A1 (en) * | 2014-02-28 | 2017-01-19 | Exosome Sciences, Inc. | Brain specific exosome based diagnostics and extracorporeal therapies |
CN108761088A (zh) * | 2018-06-28 | 2018-11-06 | 北京热景生物技术股份有限公司 | 用于糖链异常蛋白分离检测的组合物、试剂盒以及方法和用途 |
US20190049467A1 (en) * | 2015-11-20 | 2019-02-14 | Exosorme Sciences, Inc. | Exosomal tau as a biomarker for brain disorders |
CN111381043A (zh) * | 2018-12-30 | 2020-07-07 | 糖谱(北京)科技有限公司 | 一种适合质谱检测的样本前处理组合物、样本前处理方法及应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5857321A (ja) * | 1981-10-01 | 1983-04-05 | Nippon Koutai Kenkyusho:Kk | 抗癌剤 |
US20120077263A1 (en) * | 2009-06-05 | 2012-03-29 | Mayo Foundation For Medical Education And Research | Methods and materials for isolating exosomes |
US20130203061A1 (en) * | 2009-11-30 | 2013-08-08 | Michael KLASS | Methods and systems for isolating, storing, and analyzing vesicles |
US20130323756A1 (en) * | 2010-07-07 | 2013-12-05 | Aethlon Medical, Inc. | Methods and compositions for quantifying exosomes |
CN104714026B (zh) * | 2014-12-31 | 2018-08-21 | 北京热景生物技术股份有限公司 | 一种甲胎蛋白异质体的分离检测组合物、系统及其应用 |
WO2018172384A1 (en) * | 2017-03-24 | 2018-09-27 | Biovesicle Inc | Methods and kits for exosome isolation and quantification |
EP3623809A4 (en) * | 2017-05-12 | 2021-03-24 | Hiroshima University | CANCER DIAGNOSTIC DEVICE |
CN109266599A (zh) * | 2018-10-16 | 2019-01-25 | 郑州大学 | 一种高效形貌无损的外泌体分离方法 |
CN109738625A (zh) * | 2019-01-04 | 2019-05-10 | 湖南师范大学 | 一种捕获纳米磁珠、捕获外泌体的方法和应用 |
CN111253491B (zh) * | 2020-01-19 | 2022-03-25 | 北京尧景基因技术有限公司 | 一种用于分离临床样本中的糖基化外泌体的凝集素-磁性载体偶联复合物 |
-
2020
- 2020-01-19 CN CN202010060055.7A patent/CN111253491B/zh active Active
- 2020-01-19 CN CN202210166146.8A patent/CN114813264A/zh active Pending
-
2021
- 2021-01-05 EP EP21741624.7A patent/EP4092052A4/en active Pending
- 2021-01-05 WO PCT/CN2021/070288 patent/WO2021143576A1/zh unknown
- 2021-01-05 JP JP2022543156A patent/JP7383162B2/ja active Active
-
2022
- 2022-07-13 US US17/864,352 patent/US20220372173A1/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170014450A1 (en) * | 2014-02-28 | 2017-01-19 | Exosome Sciences, Inc. | Brain specific exosome based diagnostics and extracorporeal therapies |
US20190049467A1 (en) * | 2015-11-20 | 2019-02-14 | Exosorme Sciences, Inc. | Exosomal tau as a biomarker for brain disorders |
CN108761088A (zh) * | 2018-06-28 | 2018-11-06 | 北京热景生物技术股份有限公司 | 用于糖链异常蛋白分离检测的组合物、试剂盒以及方法和用途 |
CN111381043A (zh) * | 2018-12-30 | 2020-07-07 | 糖谱(北京)科技有限公司 | 一种适合质谱检测的样本前处理组合物、样本前处理方法及应用 |
Non-Patent Citations (4)
Title |
---|
JARED Q GERLACH等: "Urinary nanovesicles captured by lectins or antibodies demonstrated variations in size and surface glycosylation profile", 《NANOMEDICINE (LOND).》 * |
JUAN ECHEVARRIA等: "Microarray-based identification of lectins for the purification of human urinary extracellular vesicles directly from urine samples", 《CHEMBIOCHEM》 * |
曾韬等: "外泌体糖蛋白的研究进展", 《第二军医大学学报》 * |
高方圆等: "外泌体分离技术及其临床应用研究进展", 《高方圆》 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021143576A1 (zh) * | 2020-01-19 | 2021-07-22 | 北京热景生物技术股份有限公司 | 一种用于分离临床样本中的糖基化外泌体的凝集素-磁性载体偶联复合物 |
CN113652388A (zh) * | 2021-09-02 | 2021-11-16 | 西安龙旂生物科技有限公司 | 一种高纯度外泌体提取试剂盒及其提取方法 |
CN114540491A (zh) * | 2021-12-08 | 2022-05-27 | 北京尧景基因技术有限公司 | 一种基于岩藻糖基化细胞外囊泡中差异化表达miRNA的肝癌预测模型建立及应用 |
CN114540491B (zh) * | 2021-12-08 | 2024-01-30 | 北京尧景基因技术有限公司 | 一种基于岩藻糖基化细胞外囊泡中差异化表达miRNA的肝癌预测模型建立及应用 |
CN114354913A (zh) * | 2021-12-31 | 2022-04-15 | 厦门大学 | 一种外泌体pd-l1糖基化检测方法 |
CN115786266A (zh) * | 2023-01-31 | 2023-03-14 | 山东康华生物医疗科技股份有限公司 | 一种凝集素微阵列芯片的制备方法及捕获细胞外泌体的方法 |
CN118150843A (zh) * | 2024-04-01 | 2024-06-07 | 北京热景生物技术股份有限公司 | 一种阿尔兹海默症检测标志物糖链外泌体P-Tau-217及其应用 |
Also Published As
Publication number | Publication date |
---|---|
CN111253491B (zh) | 2022-03-25 |
US20220372173A1 (en) | 2022-11-24 |
WO2021143576A1 (zh) | 2021-07-22 |
EP4092052A1 (en) | 2022-11-23 |
JP2023503713A (ja) | 2023-01-31 |
CN114813264A (zh) | 2022-07-29 |
EP4092052A4 (en) | 2023-07-12 |
JP7383162B2 (ja) | 2023-11-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN111253491B (zh) | 一种用于分离临床样本中的糖基化外泌体的凝集素-磁性载体偶联复合物 | |
CN111257073B (zh) | 一种用于分离临床样本中的糖基化外泌体的凝集素-大分子载体偶联复合物 | |
US11079374B2 (en) | Methods and kits for exosome isolation and quantification | |
CN110231207B (zh) | 一种分离外泌体的方法 | |
US11614388B2 (en) | Method for recovering extracellular vesicles | |
CN106124282A (zh) | 一种叠层离心过滤分离提取外泌体的方法 | |
KR101999818B1 (ko) | 소수성 상호작용을 이용한 세포밖 소포체의 분리방법 | |
CN113101737B (zh) | 一种亲和切向流过滤系统及其构建方法和外泌体提取方法及应用 | |
CN112501112A (zh) | 一种快速提取组织胞外囊泡的分离富集方法 | |
CN111073846A (zh) | 一种分离组织特异来源细胞外囊泡的方法及其试剂盒 | |
CN111575228A (zh) | 一种能够得到完整外泌体的免疫磁珠分离方法 | |
CN113774008A (zh) | 一种外泌体的提取方法及其应用 | |
CN109082400A (zh) | 一种利用deae磁纳米颗粒从生物样品中分离外泌体的方法 | |
CN112852725B (zh) | 利用蛋白交联纳米亲和微球提取纯化干细胞外泌体制备方法及应用 | |
WO2023246012A1 (zh) | 一种分离提取胃癌组织来源细胞外囊泡多种亚群的方法 | |
CN114397388B (zh) | 一种基于peg沉淀法与sec柱法相结合的尿液外泌体提取试剂盒及应用 | |
CN112980006A (zh) | 蛋白交联纳米亲和微球及制备方法和应用 | |
WO2020128538A1 (en) | Novel method for identification of viruses and diagnostic kit using the same | |
CN118256489B (zh) | 一种循环核酸的提取试剂盒及循环核酸的提取方法 | |
CN109355286A (zh) | 一种免前处理自动化提取大体积全血dna的方法 | |
CN113249292A (zh) | 一种细胞外囊泡的分离方法 | |
CN111718977A (zh) | 一种分离细胞外囊泡的方法和检测细胞外囊泡的试剂盒 | |
CN113866407A (zh) | 一种外泌体her2蛋白的磁免疫化学发光检测试剂盒 | |
CN118064424A (zh) | 一种去除质粒dna中细菌内毒素的方法 | |
CN115369082A (zh) | 一种gmp车间从间充质干细胞上清提取外泌体制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB03 | Change of inventor or designer information |
Inventor after: Lin Changqing Inventor after: Chen Tiansheng Inventor after: Hao Kun Inventor after: Huang He Inventor after: Gao Qi Inventor after: Li Yanzhao Inventor after: Xu Zhihui Inventor after: Qie frost Inventor after: Zhao Guangzhen Inventor before: Lin Changqing Inventor before: Chen Tiansheng Inventor before: Hao Kun Inventor before: Huang He Inventor before: Gao Qi Inventor before: Li Yanzhao Inventor before: Xu Zhihui Inventor before: Qie frost Inventor before: Zhao Guangzhen |
|
CB03 | Change of inventor or designer information | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20211104 Address after: 102600 Room 403, 4 / F, building 10, yard 26, Yongwang West Road, Daxing biomedical industry base, Zhongguancun Science Park, Daxing District, Beijing Applicant after: Beijing Yaojing Gene Technology Co.,Ltd. Address before: 100000 Building 9, No. 9, Tianfu street, Daxing biomedical industry base, Zhongguancun Science and Technology Park, Daxing District, Beijing Applicant before: BEIJING HOTGEN BIOTECH Co.,Ltd. |
|
TA01 | Transfer of patent application right | ||
GR01 | Patent grant | ||
GR01 | Patent grant |