CN111212647B - 二氢噁二嗪酮 - Google Patents

二氢噁二嗪酮 Download PDF

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Publication number
CN111212647B
CN111212647B CN201880050751.0A CN201880050751A CN111212647B CN 111212647 B CN111212647 B CN 111212647B CN 201880050751 A CN201880050751 A CN 201880050751A CN 111212647 B CN111212647 B CN 111212647B
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CN
China
Prior art keywords
dihydro
oxadiazin
trifluoromethyl
phenyl
group
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Active
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CN201880050751.0A
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English (en)
Chinese (zh)
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CN111212647A (zh
Inventor
M.艾勒曼
S.N.格拉德尔
C.C.科皮茨
M.兰格
A.特斯泰根
P.利瑙
C.赫格尔-哈通
D.苏尔兹勒
T.A.刘易斯
H.格鲁利赫
吴晓筠
M.迈耶森
A.伯金
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Bayer AG
Bayer Pharma AG
Dana Farber Cancer Institute Inc
Broad Institute
Original Assignee
Bayer AG
Bayer Pharma AG
Dana Farber Cancer Institute Inc
Broad Institute
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C07D273/04—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201880050751.0A 2017-08-04 2018-08-02 二氢噁二嗪酮 Active CN111212647B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762541627P 2017-08-04 2017-08-04
US62/541,627 2017-08-04
PCT/EP2018/071039 WO2019025562A1 (en) 2017-08-04 2018-08-02 DIHYDROOXADIAZINONES

Publications (2)

Publication Number Publication Date
CN111212647A CN111212647A (zh) 2020-05-29
CN111212647B true CN111212647B (zh) 2024-05-14

Family

ID=63207725

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CN201880050751.0A Active CN111212647B (zh) 2017-08-04 2018-08-02 二氢噁二嗪酮

Country Status (26)

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US (3) US11427553B2 (enExample)
EP (1) EP3661517B1 (enExample)
JP (2) JP7676141B2 (enExample)
KR (1) KR20200036914A (enExample)
CN (1) CN111212647B (enExample)
AR (1) AR112402A1 (enExample)
AU (1) AU2018309356B2 (enExample)
BR (1) BR112020002351A2 (enExample)
CA (1) CA3071800A1 (enExample)
CL (1) CL2020000303A1 (enExample)
CO (1) CO2020001242A2 (enExample)
CR (1) CR20200057A (enExample)
CU (1) CU24608B1 (enExample)
EA (1) EA202090448A1 (enExample)
EC (1) ECSP20008441A (enExample)
IL (1) IL272098B2 (enExample)
JO (1) JOP20200024A1 (enExample)
MA (1) MA49750A (enExample)
MX (1) MX2020001404A (enExample)
PE (1) PE20200936A1 (enExample)
PH (1) PH12020500134A1 (enExample)
SG (1) SG11201913775UA (enExample)
TW (1) TWI791581B (enExample)
UA (1) UA125731C2 (enExample)
UY (1) UY37832A (enExample)
WO (1) WO2019025562A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20200024A1 (ar) 2017-08-04 2020-02-02 Bayer Ag مركبات ثنائي هيدروكساديازينون
EP3661917B1 (en) 2017-08-04 2022-05-11 Bayer Aktiengesellschaft 6-((3-trifluoromethyl)phenyl)-4,5-dihydropyridazin-3(2h)-one derivatives as pde3a and pde3b inhibitors for treating cancer
TW202031677A (zh) 2018-11-01 2020-09-01 美商博得學院股份有限公司 Ｐｄｅ３調節劑反應性癌症之鑑定
WO2020157188A1 (en) * 2019-02-01 2020-08-06 Bayer Aktiengesellschaft Dihydrooxadiazinones for the treatment of hyperproliferative diseases
AU2020215088A1 (en) 2019-02-01 2021-07-22 Bayer Aktiengesellschaft 1,2,4-triazin-3(2H)-one compounds for the treatment of hyperproliferative diseases
CN117279644A (zh) 2021-03-03 2023-12-22 拜耳股份有限公司 用于治疗肉瘤的取代的3,6-二氢-2h-1,3,4-噁二嗪-2-酮
EP4289828A1 (en) 2022-06-10 2023-12-13 Bayer Aktiengesellschaft Method for the preparation of a 3,6-dihydro-2h-1,3,4-oxadiazin-2-one
EP4289829A1 (en) 2022-06-10 2023-12-13 Bayer Aktiengesellschaft Crystalline forms of (6s)-5-[4'-fluoro-2-(trifluoromethyl)biphenyl-4-yl]-6-methyl-3,6-dihydro- 2h-1,3,4-oxadiazin-2-one
CN120187704A (zh) * 2022-11-24 2025-06-20 盛睿泽华医药科技（苏州）有限公司 吡啶酮化合物及其制备方法和用途
CN117903077B (zh) * 2023-01-13 2024-09-03 上海超阳药业有限公司 二氢噁二嗪酮化合物及其应用
CN118420559B (zh) * 2023-04-27 2025-02-14 上海超阳药业有限公司 氘代噁二嗪酮化合物及其用途
CN118047833B (zh) * 2024-01-31 2025-03-14 海南大学 含二茂铁的取代氨基乙酰胺类化合物及其制备方法和应用

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WO2001000601A1 (de) * 1999-06-29 2001-01-04 Bayer Aktiengesellschaft 4-(2-oxodihydrooxadiazinylphenyl)amide und ihre verwendung zur bekämpfung von anämien
CN101987848A (zh) * 2009-08-04 2011-03-23 瑟维尔实验室 新的二氢吲哚酮化合物、它们的制备方法以及包含它们的药物组合物
WO2014164704A2 (en) * 2013-03-11 2014-10-09 The Broad Institute, Inc. Compounds and compositions for the treatment of cancer
WO2017027854A1 (en) * 2015-08-13 2017-02-16 The Broad Institute, Inc. Compositions and methods for cancer expressing pde3a or slfn12

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TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
JOP20200024A1 (ar) 2017-08-04 2020-02-02 Bayer Ag مركبات ثنائي هيدروكساديازينون
EP3661917B1 (en) 2017-08-04 2022-05-11 Bayer Aktiengesellschaft 6-((3-trifluoromethyl)phenyl)-4,5-dihydropyridazin-3(2h)-one derivatives as pde3a and pde3b inhibitors for treating cancer
TW202031677A (zh) 2018-11-01 2020-09-01 美商博得學院股份有限公司 Ｐｄｅ３調節劑反應性癌症之鑑定
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Publication number Priority date Publication date Assignee Title
US4158094A (en) * 1975-08-28 1979-06-12 General Electric Company Dihydrooxadiazinones and method for making
EP0080296A1 (en) * 1981-11-12 1983-06-01 Imperial Chemical Industries Plc Pharmaceutically active phenyl-thia-, oxa- or triazinones
WO2001000601A1 (de) * 1999-06-29 2001-01-04 Bayer Aktiengesellschaft 4-(2-oxodihydrooxadiazinylphenyl)amide und ihre verwendung zur bekämpfung von anämien
CN101987848A (zh) * 2009-08-04 2011-03-23 瑟维尔实验室 新的二氢吲哚酮化合物、它们的制备方法以及包含它们的药物组合物
WO2014164704A2 (en) * 2013-03-11 2014-10-09 The Broad Institute, Inc. Compounds and compositions for the treatment of cancer
WO2017027854A1 (en) * 2015-08-13 2017-02-16 The Broad Institute, Inc. Compositions and methods for cancer expressing pde3a or slfn12

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CU20200008A7 (es) 2020-11-30
KR20200036914A (ko) 2020-04-07
WO2019025562A1 (en) 2019-02-07
US11773070B2 (en) 2023-10-03
PE20200936A1 (es) 2020-09-17
IL272098A (en) 2020-03-31
CL2020000303A1 (es) 2020-11-13
CR20200057A (es) 2020-06-16
EP3661517B1 (en) 2023-09-13
CO2020001242A2 (es) 2020-02-18
US12258323B2 (en) 2025-03-25
UY37832A (es) 2019-02-28
US11427553B2 (en) 2022-08-30
AR112402A1 (es) 2019-10-23
PH12020500134A1 (en) 2021-01-25
CN111212647A (zh) 2020-05-29
AU2018309356A1 (en) 2020-01-30
CA3071800A1 (en) 2019-02-07
ECSP20008441A (es) 2020-05-29
JP2023115065A (ja) 2023-08-18
BR112020002351A2 (pt) 2020-09-08
MX2020001404A (es) 2020-03-12
JOP20200024A1 (ar) 2020-02-02
MA49750A (fr) 2020-06-10
IL272098B1 (en) 2023-03-01
TWI791581B (zh) 2023-02-11
TW201917126A (zh) 2019-05-01
JP7676141B2 (ja) 2025-05-14
EP3661517A1 (en) 2020-06-10
US20220396554A1 (en) 2022-12-15
AU2018309356B2 (en) 2022-12-15
JP2020529439A (ja) 2020-10-08
CU24608B1 (es) 2022-06-06
SG11201913775UA (en) 2020-01-30
EA202090448A1 (ru) 2020-05-21
UA125731C2 (uk) 2022-05-25
IL272098B2 (en) 2023-07-01
US20200369633A1 (en) 2020-11-26
US20230017200A1 (en) 2023-01-19

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