CN111194225B - 用于ct成像的碘化脂肪酸的纳米乳剂 - Google Patents

用于ct成像的碘化脂肪酸的纳米乳剂 Download PDF

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Publication number
CN111194225B
CN111194225B CN201880064977.6A CN201880064977A CN111194225B CN 111194225 B CN111194225 B CN 111194225B CN 201880064977 A CN201880064977 A CN 201880064977A CN 111194225 B CN111194225 B CN 111194225B
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contrast agent
nanoemulsion
biocompatible
iodinated
fatty acids
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Chinese (zh)
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CN111194225A (zh
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劳伦特·维纳特
安德烈·巴比克
埃里克·艾利曼
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Universite de Geneve
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Universite de Geneve
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Dispersion Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Medicinal Preparation (AREA)
CN201880064977.6A 2017-08-07 2018-07-27 用于ct成像的碘化脂肪酸的纳米乳剂 Active CN111194225B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17185185.0 2017-08-07
EP17185185 2017-08-07
PCT/EP2018/070501 WO2019030024A1 (en) 2017-08-07 2018-07-27 NANOEMULSION OF IODIZED FATTY ACIDS FOR COMPUTER-ASSISTED TOMOGRAPHY (CT) IMAGING

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CN111194225A CN111194225A (zh) 2020-05-22
CN111194225B true CN111194225B (zh) 2023-01-13

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US (1) US11654202B2 (https=)
EP (1) EP3664855A1 (https=)
JP (1) JP7210542B2 (https=)
CN (1) CN111194225B (https=)
AU (1) AU2018314406B2 (https=)
BR (1) BR112020002619A2 (https=)
CA (1) CA3072282A1 (https=)
EA (1) EA202090139A1 (https=)
WO (1) WO2019030024A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118178688A (zh) 2019-02-13 2024-06-14 日内瓦大学 用于恶病质的检测的ct造影剂
CA3190518A1 (en) * 2020-08-06 2022-02-10 Adiposs SA Pet-ct imaging methods, contrast agents and pharmaceutical compositions for use in said imaging methods
CN112933246A (zh) * 2020-12-17 2021-06-11 太阳雨林（厦门）生物医药有限公司 一种可显影的油制剂及其制备方法
JP2024530159A (ja) * 2021-08-02 2024-08-16 マイクロベンション インコーポレイテッド 医療画像用ヨウ素化脂肪酸
WO2023073195A1 (en) 2021-10-28 2023-05-04 Adiposs SA Emulsions, compositions for emulsions, methods for making the same and uses thereof
WO2025079088A1 (en) * 2023-10-11 2025-04-17 Bioroot Exploration India Private Limited A contrast agent for computed tomography and process of preparation thereof

Citations (5)

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FR2736549A1 (fr) * 1995-07-11 1997-01-17 Louis Jung Esters d'acides gras iodes, acides gras iodes et leurs derives, obtenus par iodohydrination faisant intervenir des derives alkylsilyles avec des iodures alcalins et leurs activites pharmacologiques
CN101379023A (zh) * 2006-02-15 2009-03-04 通用电气医疗集团股份有限公司 造影剂
CN102166365A (zh) * 2011-04-25 2011-08-31 东南大学 一种多模态碘油纳米乳造影剂的制备方法
WO2015127347A1 (en) * 2014-02-24 2015-08-27 The Regents Of The University Of California Therapeutic hyperbranched polyglycerol encapsulated biomolecules
CN105592862A (zh) * 2013-09-30 2016-05-18 贝朗医疗有限公司 肝脏预饱和及其后造影剂的施用

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US5258172A (en) * 1983-12-29 1993-11-02 Rubin Daniel L Iodinated aliphatic emulsions for X-ray contrast
ATE89171T1 (de) 1987-06-11 1993-05-15 Kabi Pharmacia Ab Jod enthaltende emulsion.
US5861367A (en) 1993-08-04 1999-01-19 Colgate Palmolive Company Cleaning and disinfecting composition in microemulsion/liquid crystal form comprising aldehyde and mixture of partially esterified, fully esterified and non-esterified polyhydric alcohols
DE19936727A1 (de) 1999-08-06 2001-02-08 Henkel Kgaa Niotensidbasiertes wäßriges mehrphasiges Reinigungsmittel
CA2534426A1 (en) * 2003-08-08 2005-02-17 Barnes-Jewish Hospital Emulsion particles for imaging and therapy and methods of use thereof
GB0408684D0 (en) 2004-04-19 2004-05-19 Guy S And St Thomas Hospital N Diagnostic method
SG10201505948VA (en) 2004-12-13 2015-09-29 Amylin Pharmaceuticals Llc Pancreatic Polypeptide Family Motifs, Polypeptides And Methods Comprising The Same
US20080319315A1 (en) 2007-06-07 2008-12-25 Beth Israel Deaconess Medical Center Method of reducing interferences in positron emission tomography
WO2012080279A1 (en) 2010-12-17 2012-06-21 Universite De Strasbourg Radiopaque iodinated products intended for use medical imaging and their methods of preparation
KR101263733B1 (ko) 2011-03-22 2013-05-14 한국과학기술연구원 리피오돌을 함유하는 컴퓨터 단층촬영용 혈관 조영제
DE102012204378A1 (de) 2012-03-20 2013-09-26 Bernd Schwegmann Gmbh & Co. Kg Reinigungsmittel auf Mikroemulsionsbasis
US10157462B2 (en) 2016-06-27 2018-12-18 University Of Central Florida Research Foundation, Inc. System and method for image-based quantification of white and brown adipose tissue at the whole-body, organ and body-region levels

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2736549A1 (fr) * 1995-07-11 1997-01-17 Louis Jung Esters d'acides gras iodes, acides gras iodes et leurs derives, obtenus par iodohydrination faisant intervenir des derives alkylsilyles avec des iodures alcalins et leurs activites pharmacologiques
CN101379023A (zh) * 2006-02-15 2009-03-04 通用电气医疗集团股份有限公司 造影剂
CN102166365A (zh) * 2011-04-25 2011-08-31 东南大学 一种多模态碘油纳米乳造影剂的制备方法
CN105592862A (zh) * 2013-09-30 2016-05-18 贝朗医疗有限公司 肝脏预饱和及其后造影剂的施用
WO2015127347A1 (en) * 2014-02-24 2015-08-27 The Regents Of The University Of California Therapeutic hyperbranched polyglycerol encapsulated biomolecules

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
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平阳霉素碘油乳剂栓塞肺减容术的初步研究;王万胜等;《介入放射学杂志》;20060130(第01期);全文 *
经皮穿刺瘤内注射碘油化疗药乳剂在外生型肝癌介入治疗中的应用;张儒焱等;《当代医学》;20091015(第29期);全文 *

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Publication number Publication date
US11654202B2 (en) 2023-05-23
CN111194225A (zh) 2020-05-22
WO2019030024A1 (en) 2019-02-14
CA3072282A1 (en) 2019-02-14
EP3664855A1 (en) 2020-06-17
US20210330820A1 (en) 2021-10-28
AU2018314406B2 (en) 2024-08-15
AU2018314406A1 (en) 2020-02-20
JP2020529441A (ja) 2020-10-08
EA202090139A1 (ru) 2020-08-06
BR112020002619A2 (pt) 2020-07-28
JP7210542B2 (ja) 2023-01-23

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