CN111133103B - 用于制备塔格糖的组合物和利用其制备塔格糖的方法 - Google Patents

用于制备塔格糖的组合物和利用其制备塔格糖的方法 Download PDF

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CN111133103B
CN111133103B CN201880036242.2A CN201880036242A CN111133103B CN 111133103 B CN111133103 B CN 111133103B CN 201880036242 A CN201880036242 A CN 201880036242A CN 111133103 B CN111133103 B CN 111133103B
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leu
glu
val
tagatose
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CN111133103A (zh
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梁成才
李英美
朴逸香
赵显国
金成俌
李赞炯
崔殷姃
申仙美
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CJ CheilJedang Corp
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/02Monosaccharides
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90Isomerases (5.)
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/24Preparation of compounds containing saccharide radicals produced by the action of an isomerase, e.g. fructose
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01144Tagatose-6-phosphate kinase (2.7.1.144)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y401/00Carbon-carbon lyases (4.1)
    • C12Y401/02Aldehyde-lyases (4.1.2)
    • C12Y401/0204Tagatose-bisphosphate aldolase (4.1.2.40)

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  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
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  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201880036242.2A 2017-03-31 2018-03-30 用于制备塔格糖的组合物和利用其制备塔格糖的方法 Active CN111133103B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
KR20170042166 2017-03-31
KR10-2017-0042166 2017-03-31
KR10-2017-0111494 2017-08-31
KR20170111494 2017-08-31
KR10-2017-0158766 2017-11-24
KR20170158766 2017-11-24
PCT/KR2018/003769 WO2018182355A1 (ko) 2017-03-31 2018-03-30 타가토스 생산용 조성물 및 이를 이용한 타가토스 제조방법

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CN111133103A CN111133103A (zh) 2020-05-08
CN111133103B true CN111133103B (zh) 2024-03-08

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US (1) US11408017B2 (enExample)
EP (1) EP3604516A4 (enExample)
JP (1) JP6961713B2 (enExample)
KR (1) KR102076288B1 (enExample)
CN (1) CN111133103B (enExample)
BR (1) BR112019020338B1 (enExample)
CA (1) CA3057595C (enExample)
MX (1) MX2019011730A (enExample)
TW (1) TWI704227B (enExample)
WO (1) WO2018182355A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102074957B1 (ko) 2017-03-31 2020-02-10 씨제이제일제당 주식회사 타가토스 생산용 조성물 및 이를 이용한 타가토스 제조방법
CN109750024B (zh) * 2017-11-02 2021-12-14 中国科学院天津工业生物技术研究所 一种6磷酸塔格糖4位差向异构酶及其应用
CN113366112B (zh) 2018-10-19 2024-10-25 博努莫斯股份有限公司 塔格糖的酶法生产
KR102194285B1 (ko) * 2018-10-19 2020-12-23 씨제이제일제당 주식회사 신규 과당-4-에피머화 효소 및 이를 이용한 타가토스의 제조 방법
KR102219195B1 (ko) 2019-08-14 2021-02-24 씨제이제일제당 주식회사 신규 과당-4-에피머화 효소 및 이를 이용한 타가토스의 제조 방법
CN112342178B (zh) * 2020-11-05 2022-02-25 中国科学院天津工业生物技术研究所 重组微生物、其制备方法及在生产塔格糖中的应用
EP4464785A1 (de) 2023-05-15 2024-11-20 Annikki GmbH Verfahren zur herstellung von d-talitol, d-tagatose und d-psicose
WO2024236043A1 (de) 2023-05-15 2024-11-21 Annikki Gmbh Verfahren zur herstellung von d-talitol, d-tagatose und d-psicose

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101480422B1 (ko) * 2013-07-29 2015-01-13 건국대학교 산학협력단 효소조합 반응에 의한 과당으로부터 타가토스 생산 방법 및 그 조성물
CN106399427A (zh) * 2016-11-01 2017-02-15 中国科学院天津工业生物技术研究所 塔格糖的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006058092A2 (en) 2004-11-22 2006-06-01 Cargill, Incorporated Monosaccharide production system
KR100744479B1 (ko) 2005-06-01 2007-08-01 씨제이 주식회사 사이코스 에피머화 효소에 의한 사이코스의 생산 방법
KR100964091B1 (ko) * 2008-01-28 2010-06-16 씨제이제일제당 (주) 대두 올리고당을 이용한 타가토스의 제조 방법
WO2009145576A2 (ko) 2008-05-30 2009-12-03 주식회사 삼양제넥스 알도헥소오스 에피머라아제 및 이를 이용한 알도헥소오스 에피머의 효소적 제조 방법
KR101368731B1 (ko) 2012-01-19 2014-03-06 씨제이제일제당 (주) 유청 막 투과액 또는 유청 막 투과 분말로부터 타가토스의 제조 원료가 되는 갈락토스를 제조하는 방법
KR101610911B1 (ko) * 2013-05-09 2016-04-08 주식회사 삼양사 L-리불로스 5-인산 4-에피머화 효소를 이용한 과당에서 타가토스 생산
CN105431541B (zh) * 2013-06-05 2019-09-24 Cj第一制糖株式会社 塔格糖的生产方法、大肠杆菌及己酮糖c4-差向异构酶突变体
US9914919B2 (en) * 2013-07-29 2018-03-13 Samyang Corporation Aldolase, aldolase mutant, and method and composition for producing tagatose by using same
KR101620904B1 (ko) * 2013-10-11 2016-05-23 (주)케비젠 기질 및 효소 컴비네이션 반응을 이용한 프럭토스로부터 타가토스 생산용 조성물 및 이의 용도
KR101638024B1 (ko) * 2014-10-22 2016-07-20 씨제이제일제당(주) 타가토스 제조용 조성물 및 과당으로부터 타가토스를 제조하는 방법
PT3322803T (pt) * 2015-10-02 2021-04-28 Bonumose Llc Produção enzimática de d-tagatose
KR102074957B1 (ko) * 2017-03-31 2020-02-10 씨제이제일제당 주식회사 타가토스 생산용 조성물 및 이를 이용한 타가토스 제조방법
CN109750024B (zh) * 2017-11-02 2021-12-14 中国科学院天津工业生物技术研究所 一种6磷酸塔格糖4位差向异构酶及其应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101480422B1 (ko) * 2013-07-29 2015-01-13 건국대학교 산학협력단 효소조합 반응에 의한 과당으로부터 타가토스 생산 방법 및 그 조성물
CN106399427A (zh) * 2016-11-01 2017-02-15 中国科学院天津工业生物技术研究所 塔格糖的制备方法

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ATP-binding Cassette (ABC) Transport System Solute-binding Protein-guided Identification of Novel D-Altritol and Galactitol Catabolic Pathways in Agrobacterium tumefaciens C58;Daniel J. Wichelecki等;THE JOURNAL OF BIOLOGICAL CHEMISTRY;第290卷(第290期);28963-28976 *
Catalysis, Structures, and Applications of Carbohydrate Epimerases;Susumu Ito;J. Appl. Glycosci.,;第57卷;1-6 *
Daniel J. Wichelecki等.ATP-binding Cassette (ABC) Transport System Solute-binding Protein-guided Identification of Novel D-Altritol and Galactitol Catabolic Pathways in Agrobacterium tumefaciens C58.THE JOURNAL OF BIOLOGICAL CHEMISTRY.2015,第290卷(第290期),28963-28976. *
hypothetical protein [Thermoanaerobacter indiensis].NCBI.2013,WP_019907213.1. *
MAG: hypothetical protein AMJ56_01405 [Anaerolineae bacterium SG8_19].NCBI.2015,KPK13642.1. *
MULTISPECIES: tagatose-6-phosphate kinase [Agrobacterium tumefaciens complex].NCBI.2015,WP_010972812.. *
putative tagatose-6-phosphate kinase [Anaerolinea thermophila UNI-1].NCBI.2016,BAJ62431.1. *
tagatose 6 phosphate kinase [Dictyoglomus thermophilum H-6-12].NCBI.2014,ACI19904.1. *
UniParc · UPI000838E548.EBI.2016,UPI000838E548. *

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Publication number Publication date
TWI704227B (zh) 2020-09-11
BR112019020338A8 (pt) 2023-04-04
MX2019011730A (es) 2020-12-07
CA3057595C (en) 2024-11-12
EP3604516A1 (en) 2020-02-05
BR112019020338A2 (pt) 2020-04-28
WO2018182355A1 (ko) 2018-10-04
TW201842187A (zh) 2018-12-01
KR102076288B1 (ko) 2020-02-10
US20200087689A1 (en) 2020-03-19
JP6961713B2 (ja) 2021-11-05
KR20180111679A (ko) 2018-10-11
CN111133103A (zh) 2020-05-08
EP3604516A4 (en) 2021-01-20
CA3057595A1 (en) 2018-10-04
US11408017B2 (en) 2022-08-09
BR112019020338B1 (pt) 2023-05-02
JP2020511974A (ja) 2020-04-23

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