CN111053768B - 用于治疗黑素瘤的药物组合 - Google Patents

用于治疗黑素瘤的药物组合 Download PDF

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Publication number
CN111053768B
CN111053768B CN201911007262.XA CN201911007262A CN111053768B CN 111053768 B CN111053768 B CN 111053768B CN 201911007262 A CN201911007262 A CN 201911007262A CN 111053768 B CN111053768 B CN 111053768B
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inhibitor
melanoma
braf
compound
mek
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Chinese (zh)
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CN111053768A (zh
Inventor
V·阿嘎沃尔
G·派力亚萨麦
玛吉·拉索斯
安吉塔·斯里瓦斯塔瓦
斯丽莎·斯里尼瓦莎
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Piramal Enterprises Ltd
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Piramal Enterprises Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201911007262.XA 2013-07-12 2014-07-11 用于治疗黑素瘤的药物组合 Active CN111053768B (zh)

Priority Applications (1)

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CN201911007262.XA CN111053768B (zh) 2013-07-12 2014-07-11 用于治疗黑素瘤的药物组合

Applications Claiming Priority (5)

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US201361845749P 2013-07-12 2013-07-12
US61/845,749 2013-07-12
PCT/IB2014/063022 WO2015004636A1 (en) 2013-07-12 2014-07-11 A pharmaceutical combination for the treatment of melanoma
CN201911007262.XA CN111053768B (zh) 2013-07-12 2014-07-11 用于治疗黑素瘤的药物组合
CN201480050507.6A CN105530931B (zh) 2013-07-12 2014-07-11 用于治疗黑素瘤的药物组合

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CN111053768B true CN111053768B (zh) 2023-12-12

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CN202311581824.8A Pending CN117731786A (zh) 2013-07-12 2014-07-11 用于治疗黑素瘤的药物组合
CN201480050507.6A Active CN105530931B (zh) 2013-07-12 2014-07-11 用于治疗黑素瘤的药物组合

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CN201480050507.6A Active CN105530931B (zh) 2013-07-12 2014-07-11 用于治疗黑素瘤的药物组合

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US (4) US11007174B2 (enExample)
EP (1) EP3019166B1 (enExample)
JP (5) JP6568060B2 (enExample)
CN (3) CN111053768B (enExample)
AR (1) AR096892A1 (enExample)
AU (1) AU2014288857B2 (enExample)
CA (1) CA2917742C (enExample)
DK (1) DK3019166T3 (enExample)
ES (1) ES2733929T3 (enExample)
IL (1) IL243572B (enExample)
TW (4) TW202502325A (enExample)
WO (1) WO2015004636A1 (enExample)

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AU2018368453B2 (en) 2017-11-17 2024-05-30 The Board Of Trustees Of The University Of Illinois Cancer therapy by degrading dual MEK signaling
CN107827726B (zh) * 2017-11-28 2020-09-15 辽宁中医药大学 马齿苋中化合物Oleracone E及其提取分离方法
CN108591464B (zh) * 2018-06-28 2020-06-23 宁波奥克斯高科技有限公司 一种气体绝缘开关柜用密封结构
WO2020072774A1 (en) * 2018-10-05 2020-04-09 The Board Of Trustees Of The University Of Illinois Combination therapy for the treatment of uveal melanoma
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CN112168821B (zh) * 2020-11-09 2022-10-14 中南大学湘雅医院 一种治疗维罗非尼耐药的黑色素瘤的联合用药物及其应用
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CN117043159A (zh) * 2020-11-19 2023-11-10 梅制药公司 Kras突变型癌症的治疗

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Also Published As

Publication number Publication date
ES2733929T3 (es) 2019-12-03
TW202502325A (zh) 2025-01-16
EP3019166A1 (en) 2016-05-18
IL243572B (en) 2019-10-31
CA2917742C (en) 2020-04-14
US20160136132A1 (en) 2016-05-19
US11839591B2 (en) 2023-12-12
CN105530931B (zh) 2019-11-08
TW201534297A (zh) 2015-09-16
TW202233177A (zh) 2022-09-01
CN105530931A (zh) 2016-04-27
US20190282544A1 (en) 2019-09-19
EP3019166A4 (en) 2017-04-19
CN111053768A (zh) 2020-04-24
AR096892A1 (es) 2016-02-03
TWI680760B (zh) 2020-01-01
JP2019206565A (ja) 2019-12-05
TW202031253A (zh) 2020-09-01
JP2021001186A (ja) 2021-01-07
JP2016525097A (ja) 2016-08-22
JP7799508B2 (ja) 2026-01-15
DK3019166T3 (da) 2019-07-29
AU2014288857A1 (en) 2016-02-04
WO2015004636A1 (en) 2015-01-15
CA2917742A1 (en) 2015-01-15
JP2024037891A (ja) 2024-03-19
EP3019166B1 (en) 2019-05-08
JP2022068335A (ja) 2022-05-09
CN117731786A (zh) 2024-03-22
US11007174B2 (en) 2021-05-18
US20240165076A1 (en) 2024-05-23
IL243572A0 (en) 2016-02-29
TWI839690B (zh) 2024-04-21
AU2014288857B2 (en) 2019-03-14
US20210393589A1 (en) 2021-12-23
JP6568060B2 (ja) 2019-08-28
US12383530B2 (en) 2025-08-12

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