TW202502325A - 治療黑色素瘤的藥物組合的用途 - Google Patents

治療黑色素瘤的藥物組合的用途 Download PDF

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Publication number
TW202502325A
TW202502325A TW113110009A TW113110009A TW202502325A TW 202502325 A TW202502325 A TW 202502325A TW 113110009 A TW113110009 A TW 113110009A TW 113110009 A TW113110009 A TW 113110009A TW 202502325 A TW202502325 A TW 202502325A
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TW
Taiwan
Prior art keywords
melanoma
compound
inhibitor
pharmaceutical composition
cdk inhibitor
Prior art date
Application number
TW113110009A
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English (en)
Chinese (zh)
Inventor
維納 阿葛瓦爾
葛瑞得哈倫 派瑞亞沙米
瑪基 喬伊斯 拉瑟斯
安基塔 斯里瓦斯塔瓦
蘇里薩 錫里尼娃撒
Original Assignee
印度商皮拉馬爾企業有限公司
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Application filed by 印度商皮拉馬爾企業有限公司 filed Critical 印度商皮拉馬爾企業有限公司
Publication of TW202502325A publication Critical patent/TW202502325A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW113110009A 2013-07-12 2014-07-11 治療黑色素瘤的藥物組合的用途 TW202502325A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361845749P 2013-07-12 2013-07-12
US61/845,749 2013-07-12

Publications (1)

Publication Number Publication Date
TW202502325A true TW202502325A (zh) 2025-01-16

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Family Applications (4)

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TW113110009A TW202502325A (zh) 2013-07-12 2014-07-11 治療黑色素瘤的藥物組合的用途
TW103123951A TWI680760B (zh) 2013-07-12 2014-07-11 治療黑色素瘤的藥物組合
TW111106633A TWI839690B (zh) 2013-07-12 2014-07-11 治療黑色素瘤的藥物組合的用途
TW108142557A TW202031253A (zh) 2013-07-12 2014-07-11 治療黑色素瘤的藥物組合

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TW103123951A TWI680760B (zh) 2013-07-12 2014-07-11 治療黑色素瘤的藥物組合
TW111106633A TWI839690B (zh) 2013-07-12 2014-07-11 治療黑色素瘤的藥物組合的用途
TW108142557A TW202031253A (zh) 2013-07-12 2014-07-11 治療黑色素瘤的藥物組合

Country Status (12)

Country Link
US (4) US11007174B2 (enExample)
EP (1) EP3019166B1 (enExample)
JP (5) JP6568060B2 (enExample)
CN (3) CN111053768B (enExample)
AR (1) AR096892A1 (enExample)
AU (1) AU2014288857B2 (enExample)
CA (1) CA2917742C (enExample)
DK (1) DK3019166T3 (enExample)
ES (1) ES2733929T3 (enExample)
IL (1) IL243572B (enExample)
TW (4) TW202502325A (enExample)
WO (1) WO2015004636A1 (enExample)

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CN112168821B (zh) * 2020-11-09 2022-10-14 中南大学湘雅医院 一种治疗维罗非尼耐药的黑色素瘤的联合用药物及其应用
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CN117043159A (zh) * 2020-11-19 2023-11-10 梅制药公司 Kras突变型癌症的治疗

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Also Published As

Publication number Publication date
ES2733929T3 (es) 2019-12-03
EP3019166A1 (en) 2016-05-18
IL243572B (en) 2019-10-31
CA2917742C (en) 2020-04-14
US20160136132A1 (en) 2016-05-19
US11839591B2 (en) 2023-12-12
CN105530931B (zh) 2019-11-08
TW201534297A (zh) 2015-09-16
TW202233177A (zh) 2022-09-01
CN105530931A (zh) 2016-04-27
US20190282544A1 (en) 2019-09-19
EP3019166A4 (en) 2017-04-19
CN111053768A (zh) 2020-04-24
AR096892A1 (es) 2016-02-03
TWI680760B (zh) 2020-01-01
JP2019206565A (ja) 2019-12-05
TW202031253A (zh) 2020-09-01
JP2021001186A (ja) 2021-01-07
JP2016525097A (ja) 2016-08-22
JP7799508B2 (ja) 2026-01-15
DK3019166T3 (da) 2019-07-29
AU2014288857A1 (en) 2016-02-04
WO2015004636A1 (en) 2015-01-15
CA2917742A1 (en) 2015-01-15
JP2024037891A (ja) 2024-03-19
EP3019166B1 (en) 2019-05-08
JP2022068335A (ja) 2022-05-09
CN117731786A (zh) 2024-03-22
US11007174B2 (en) 2021-05-18
US20240165076A1 (en) 2024-05-23
IL243572A0 (en) 2016-02-29
TWI839690B (zh) 2024-04-21
AU2014288857B2 (en) 2019-03-14
US20210393589A1 (en) 2021-12-23
CN111053768B (zh) 2023-12-12
JP6568060B2 (ja) 2019-08-28
US12383530B2 (en) 2025-08-12

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