JP6568060B2 - 黒色腫の治療のための組合せ医薬 - Google Patents

黒色腫の治療のための組合せ医薬 Download PDF

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Publication number
JP6568060B2
JP6568060B2 JP2016524936A JP2016524936A JP6568060B2 JP 6568060 B2 JP6568060 B2 JP 6568060B2 JP 2016524936 A JP2016524936 A JP 2016524936A JP 2016524936 A JP2016524936 A JP 2016524936A JP 6568060 B2 JP6568060 B2 JP 6568060B2
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melanoma
braf
compound
inhibitor
effective amount
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JP2016525097A5 (enExample
JP2016525097A (ja
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アガーワル，ヴィーナ
ペリヤサミ，ギリドハラン
ラトス，マギー
シュリーヴァスタヴァ，アンキタ
シュリニヴァーサ，スリーシャ
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ピラマル エンタープライズイズ リミテッド
ピラマル エンタープライズイズ リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2016524936A 2013-07-12 2014-07-11 黒色腫の治療のための組合せ医薬 Active JP6568060B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361845749P 2013-07-12 2013-07-12
US61/845,749 2013-07-12
PCT/IB2014/063022 WO2015004636A1 (en) 2013-07-12 2014-07-11 A pharmaceutical combination for the treatment of melanoma

Related Child Applications (1)

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JP2019141995A Division JP2019206565A (ja) 2013-07-12 2019-08-01 黒色腫の治療のための組合せ医薬

Publications (3)

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JP2016525097A JP2016525097A (ja) 2016-08-22
JP2016525097A5 JP2016525097A5 (enExample) 2017-08-10
JP6568060B2 true JP6568060B2 (ja) 2019-08-28

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JP2016524936A Active JP6568060B2 (ja) 2013-07-12 2014-07-11 黒色腫の治療のための組合せ医薬
JP2019141995A Pending JP2019206565A (ja) 2013-07-12 2019-08-01 黒色腫の治療のための組合せ医薬
JP2020152028A Pending JP2021001186A (ja) 2013-07-12 2020-09-10 黒色腫の治療のための組合せ医薬
JP2022026851A Active JP7799508B2 (ja) 2013-07-12 2022-02-24 黒色腫の治療のための組合せ医薬
JP2023210858A Pending JP2024037891A (ja) 2013-07-12 2023-12-14 黒色腫の治療のための組合せ医薬

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JP2020152028A Pending JP2021001186A (ja) 2013-07-12 2020-09-10 黒色腫の治療のための組合せ医薬
JP2022026851A Active JP7799508B2 (ja) 2013-07-12 2022-02-24 黒色腫の治療のための組合せ医薬
JP2023210858A Pending JP2024037891A (ja) 2013-07-12 2023-12-14 黒色腫の治療のための組合せ医薬

Country Status (12)

Country Link
US (4) US11007174B2 (enExample)
EP (1) EP3019166B1 (enExample)
JP (5) JP6568060B2 (enExample)
CN (3) CN105530931B (enExample)
AR (1) AR096892A1 (enExample)
AU (1) AU2014288857B2 (enExample)
CA (1) CA2917742C (enExample)
DK (1) DK3019166T3 (enExample)
ES (1) ES2733929T3 (enExample)
IL (1) IL243572B (enExample)
TW (4) TWI839690B (enExample)
WO (1) WO2015004636A1 (enExample)

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Also Published As

Publication number Publication date
CN111053768A (zh) 2020-04-24
TWI680760B (zh) 2020-01-01
CN117731786A (zh) 2024-03-22
WO2015004636A1 (en) 2015-01-15
TW202233177A (zh) 2022-09-01
JP2022068335A (ja) 2022-05-09
TW202031253A (zh) 2020-09-01
EP3019166B1 (en) 2019-05-08
IL243572A0 (en) 2016-02-29
EP3019166A1 (en) 2016-05-18
DK3019166T3 (da) 2019-07-29
IL243572B (en) 2019-10-31
AU2014288857A1 (en) 2016-02-04
TW201534297A (zh) 2015-09-16
JP2021001186A (ja) 2021-01-07
US20160136132A1 (en) 2016-05-19
CA2917742C (en) 2020-04-14
US20210393589A1 (en) 2021-12-23
JP2024037891A (ja) 2024-03-19
TWI839690B (zh) 2024-04-21
JP7799508B2 (ja) 2026-01-15
CN105530931B (zh) 2019-11-08
CN105530931A (zh) 2016-04-27
CN111053768B (zh) 2023-12-12
US20190282544A1 (en) 2019-09-19
US12383530B2 (en) 2025-08-12
JP2016525097A (ja) 2016-08-22
US11007174B2 (en) 2021-05-18
AU2014288857B2 (en) 2019-03-14
ES2733929T3 (es) 2019-12-03
AR096892A1 (es) 2016-02-03
EP3019166A4 (en) 2017-04-19
CA2917742A1 (en) 2015-01-15
TW202502325A (zh) 2025-01-16
JP2019206565A (ja) 2019-12-05
US20240165076A1 (en) 2024-05-23
US11839591B2 (en) 2023-12-12

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