CN111051335A - 一种拟穴青蟹抗菌肽Sparamosin及其应用 - Google Patents

一种拟穴青蟹抗菌肽Sparamosin及其应用 Download PDF

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CN111051335A
CN111051335A CN201880057220.4A CN201880057220A CN111051335A CN 111051335 A CN111051335 A CN 111051335A CN 201880057220 A CN201880057220 A CN 201880057220A CN 111051335 A CN111051335 A CN 111051335A
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sparamosin
antibacterial
peptide
application
scylla paramamosain
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CN111051335B (zh
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王克坚
陈炎超
陈芳奕
杨盈
彭会
陈慧芸
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Xiamen University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43509—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from crustaceans
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/20—Animal feeding-stuffs from material of animal origin
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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Abstract

提供了一种拟穴青蟹抗菌肽Sparamosin，采用现有的固相化学合成的方法得到纯度达95％以上的Sparamosin成熟肽及其功能结构域Sparamosin26‑54，上述肽来源于水产甲壳动物，具有抗菌活性，可以应用于水产作为饲料添加剂，也可以研制成为防霉防腐剂、抗菌剂和抗菌药物等。Sparamosin26‑54具有抗真菌活性，能抑杀多种酵母真菌和丝状真菌的生长。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN201880057220.4A 2018-06-20 2018-06-20 一种拟穴青蟹抗菌肽Sparamosin及其应用 Active CN111051335B (zh)

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PCT/CN2018/092043 WO2019241938A1 (zh) 2018-06-20 2018-06-20 一种拟穴青蟹抗菌肽Sparamosin及其应用

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113307855A (zh) * 2021-06-25 2021-08-27 厦门大学 拟穴青蟹抗菌多肽Spampcin56-86及其应用
CN113974022A (zh) * 2021-10-21 2022-01-28 厦门海嘉成生物科技有限公司 一种抗菌肽的应用
CN114014923A (zh) * 2020-10-27 2022-02-08 厦门大学 拟穴青蟹抗菌多肽Sp-LECin及其应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114716512B (zh) * 2021-06-28 2022-12-16 厦门大学 一种青蟹广谱抗菌肽Scyampcin44-63及其应用
CN114014910B (zh) * 2021-11-18 2022-12-09 厦门大学 一种拟穴青蟹抗真菌多肽Spamptin72-91及其应用
CN114409754B (zh) * 2021-12-30 2023-09-12 集美大学 一种微电压方法协同抗菌肽pv-q5及其用途
CN114773436B (zh) * 2022-04-27 2023-01-03 厦门大学 一种拟穴青蟹抗菌多肽SpRR20及其应用
CN115246876B (zh) * 2022-06-09 2024-06-18 厦门大学 一种拟穴青蟹抗菌多肽Scyrepsin34-55及其应用

Citations (3)

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CN102167736A (zh) * 2011-05-17 2011-08-31 厦门大学 一种拟穴青蟹抗菌肽Sphistin及其应用
CN102304516A (zh) * 2011-08-29 2012-01-04 厦门大学 拟穴青蟹阴离子抗菌肽的毕赤酵母表达产物及其制备方法
CN105274134A (zh) * 2015-11-25 2016-01-27 厦门大学 拟穴青蟹抗菌肽scy2的制备方法与应用

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CN103789317A (zh) * 2014-01-08 2014-05-14 广西壮族自治区海洋研究所 拟穴青蟹抗菌肽hyastatin基因克隆及编码蛋白重组和用途

Patent Citations (3)

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CN102167736A (zh) * 2011-05-17 2011-08-31 厦门大学 一种拟穴青蟹抗菌肽Sphistin及其应用
CN102304516A (zh) * 2011-08-29 2012-01-04 厦门大学 拟穴青蟹阴离子抗菌肽的毕赤酵母表达产物及其制备方法
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YAN-CHAO CHEN等: "A Novel Antimicrobial Peptide Sparamosin 26-54 From the Mud Crab Scylla paramamosain Showing Potent Antifungal Activity Against Cryptococcus neoformans", 《FRONT MICROBIOL》 *
陈炎超: "拟穴青蟹新型抗菌肽Sp-AMP的特性分析及其抗真菌机制的初步研究", 《中国优秀博硕士学位论文全文数据库(硕士)农业科技辑》 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114014923A (zh) * 2020-10-27 2022-02-08 厦门大学 拟穴青蟹抗菌多肽Sp-LECin及其应用
CN114014923B (zh) * 2020-10-27 2022-11-01 厦门大学 拟穴青蟹抗菌多肽Sp-LECin及其应用
CN113307855A (zh) * 2021-06-25 2021-08-27 厦门大学 拟穴青蟹抗菌多肽Spampcin56-86及其应用
WO2022268115A1 (zh) * 2021-06-25 2022-12-29 厦门大学 拟穴青蟹抗菌多肽Spampcin 56-86及其应用
CN113307855B (zh) * 2021-06-25 2023-08-01 厦门大学 拟穴青蟹抗菌多肽Spampcin56-86及其应用
CN113974022A (zh) * 2021-10-21 2022-01-28 厦门海嘉成生物科技有限公司 一种抗菌肽的应用

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US20210061865A1 (en) 2021-03-04
CN111051335B (zh) 2022-06-21
US11254717B2 (en) 2022-02-22

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