CN110997651B - 新的四唑化合物和它们在治疗结核病中的用途 - Google Patents
新的四唑化合物和它们在治疗结核病中的用途 Download PDFInfo
- Publication number
- CN110997651B CN110997651B CN201880053320.XA CN201880053320A CN110997651B CN 110997651 B CN110997651 B CN 110997651B CN 201880053320 A CN201880053320 A CN 201880053320A CN 110997651 B CN110997651 B CN 110997651B
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- CN
- China
- Prior art keywords
- tetrazol
- benzenesulfonamide
- hydroxyethyl
- methyl
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17382574 | 2017-08-17 | ||
| EP17382574.6 | 2017-08-17 | ||
| PCT/EP2018/072205 WO2019034729A1 (en) | 2017-08-17 | 2018-08-16 | NOVEL TETRAZOLE COMPOUNDS AND THEIR USE IN THE TREATMENT OF TUBERCULOSIS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110997651A CN110997651A (zh) | 2020-04-10 |
| CN110997651B true CN110997651B (zh) | 2023-01-03 |
Family
ID=59713960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880053320.XA Active CN110997651B (zh) | 2017-08-17 | 2018-08-16 | 新的四唑化合物和它们在治疗结核病中的用途 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US11072591B2 (https=) |
| EP (1) | EP3668856B1 (https=) |
| JP (1) | JP7410017B2 (https=) |
| KR (1) | KR102661367B1 (https=) |
| CN (1) | CN110997651B (https=) |
| AU (1) | AU2018317812C1 (https=) |
| CA (1) | CA3072854A1 (https=) |
| CY (1) | CY1124577T1 (https=) |
| DK (1) | DK3668856T3 (https=) |
| ES (1) | ES2885573T3 (https=) |
| HR (1) | HRP20211326T1 (https=) |
| HU (1) | HUE055732T2 (https=) |
| LT (1) | LT3668856T (https=) |
| PL (1) | PL3668856T3 (https=) |
| PT (1) | PT3668856T (https=) |
| RS (1) | RS62267B1 (https=) |
| SI (1) | SI3668856T1 (https=) |
| SM (1) | SMT202100515T1 (https=) |
| WO (1) | WO2019034729A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111184718A (zh) * | 2018-11-15 | 2020-05-22 | 鲁南制药集团股份有限公司 | 法罗培南在制备治疗初治病原学阳性肺结核药物中的用途 |
| CN115403533B (zh) * | 2021-05-28 | 2023-08-25 | 永康市第一人民医院 | 一种1-苯乙烯基-1,2,3-三氮唑化合物及其制备方法和应用 |
| CN116102483B (zh) * | 2021-11-09 | 2025-01-17 | 中国医学科学院药物研究所 | 取代吡咯-2,5-二酮类化合物及其制备方法和用途 |
| CN116726018A (zh) * | 2023-08-02 | 2023-09-12 | 上海市肺科医院（上海市职业病防治院） | 一种贝达喹啉、德拉马尼、氯法齐明和吡嗪酰胺的联用和应用 |
| CN117379430A (zh) * | 2023-10-11 | 2024-01-12 | 深圳市第三人民医院(深圳市肝病研究所) | 一种地拉韦啶的用途 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101679318A (zh) * | 2007-04-05 | 2010-03-24 | 美国西门子医疗解决公司 | 使用链接化学法的用于碳酸酐酶-ix的分子成象探针的发展 |
| WO2017066964A1 (en) * | 2015-10-22 | 2017-04-27 | Merck Sharp & Dohme Corp. | Oxazolidinone compounds and methods of use thereof as antibacterial agents |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3621427B2 (ja) | 1997-07-22 | 2005-02-16 | 塩野義製薬株式会社 | 糸球体障害治療または予防剤 |
-
2018
- 2018-08-16 WO PCT/EP2018/072205 patent/WO2019034729A1/en not_active Ceased
- 2018-08-16 ES ES18755815T patent/ES2885573T3/es active Active
- 2018-08-16 HR HRP20211326TT patent/HRP20211326T1/hr unknown
- 2018-08-16 US US16/639,163 patent/US11072591B2/en active Active
- 2018-08-16 PT PT187558150T patent/PT3668856T/pt unknown
- 2018-08-16 JP JP2020508427A patent/JP7410017B2/ja active Active
- 2018-08-16 SM SM20210515T patent/SMT202100515T1/it unknown
- 2018-08-16 EP EP18755815.0A patent/EP3668856B1/en active Active
- 2018-08-16 CN CN201880053320.XA patent/CN110997651B/zh active Active
- 2018-08-16 CA CA3072854A patent/CA3072854A1/en active Pending
- 2018-08-16 LT LTEPPCT/EP2018/072205T patent/LT3668856T/lt unknown
- 2018-08-16 SI SI201830348T patent/SI3668856T1/sl unknown
- 2018-08-16 PL PL18755815T patent/PL3668856T3/pl unknown
- 2018-08-16 RS RS20211076A patent/RS62267B1/sr unknown
- 2018-08-16 AU AU2018317812A patent/AU2018317812C1/en active Active
- 2018-08-16 KR KR1020207007186A patent/KR102661367B1/ko active Active
- 2018-08-16 DK DK18755815.0T patent/DK3668856T3/da active
- 2018-08-16 HU HUE18755815A patent/HUE055732T2/hu unknown
-
2021
- 2021-08-31 CY CY20211100770T patent/CY1124577T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101679318A (zh) * | 2007-04-05 | 2010-03-24 | 美国西门子医疗解决公司 | 使用链接化学法的用于碳酸酐酶-ix的分子成象探针的发展 |
| WO2017066964A1 (en) * | 2015-10-22 | 2017-04-27 | Merck Sharp & Dohme Corp. | Oxazolidinone compounds and methods of use thereof as antibacterial agents |
Non-Patent Citations (4)
| Title |
|---|
| In vitro evaluation of tetrazoles as a novel class of Antimycobacterium tuberculosis agents;Mohite P.B.等;《Advanced Pharmaceutical Bulletin》;20120215;31-36 * |
| Rama P. Tripathi等.Application of Huisgen (3 þ2) cycloaddition reaction: Synthesis of 1-(2,3-dihydrobenzofuran-2-yl-methyl [1,2,3]-triazoles and their antitubercular evaluations.《European Journal of Medicinal Chemistry》.2009,142-148. * |
| Synthesis and biological activities of triazole derivatives as inhibitors of InhA and antituberculosis agents;Christophe Menendez等;《European Journal of Medicinal Chemistry》;20110916;5524-5531 * |
| Triazole: A Promising Antitubercular Agent;Rangappa S. Keri等;《Chem Biol Drug Des》;20150124;410-423 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3668856B1 (en) | 2021-06-23 |
| WO2019034729A1 (en) | 2019-02-21 |
| BR112020003247A2 (pt) | 2020-08-18 |
| JP2020531425A (ja) | 2020-11-05 |
| CA3072854A1 (en) | 2019-02-21 |
| ES2885573T3 (es) | 2021-12-14 |
| CN110997651A (zh) | 2020-04-10 |
| SMT202100515T1 (it) | 2021-11-12 |
| PL3668856T3 (pl) | 2021-12-13 |
| CY1124577T1 (el) | 2022-07-22 |
| RU2020110818A (ru) | 2021-09-17 |
| EP3668856A1 (en) | 2020-06-24 |
| US20200231555A1 (en) | 2020-07-23 |
| RS62267B1 (sr) | 2021-09-30 |
| US11072591B2 (en) | 2021-07-27 |
| KR20200041915A (ko) | 2020-04-22 |
| JP7410017B2 (ja) | 2024-01-09 |
| HRP20211326T1 (hr) | 2021-11-26 |
| PT3668856T (pt) | 2021-09-15 |
| AU2018317812B2 (en) | 2021-04-15 |
| DK3668856T3 (da) | 2021-09-20 |
| HUE055732T2 (hu) | 2021-12-28 |
| RU2020110818A3 (https=) | 2021-10-11 |
| AU2018317812A1 (en) | 2020-02-20 |
| AU2018317812C1 (en) | 2021-08-26 |
| KR102661367B1 (ko) | 2024-04-29 |
| SI3668856T1 (sl) | 2021-11-30 |
| LT3668856T (lt) | 2021-09-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: Steve Niki Patentee after: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT Ltd. Country or region after: United Kingdom Address before: British Meader Sykes Patentee before: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT Ltd. Country or region before: United Kingdom |
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| CP03 | Change of name, title or address |