HRP20211326T1 - Novi spojevi tetrazola i njihova primjena u liječenju tuberkuloze - Google Patents

Novi spojevi tetrazola i njihova primjena u liječenju tuberkuloze Download PDF

Info

Publication number
HRP20211326T1
HRP20211326T1 HRP20211326TT HRP20211326T HRP20211326T1 HR P20211326 T1 HRP20211326 T1 HR P20211326T1 HR P20211326T T HRP20211326T T HR P20211326TT HR P20211326 T HRP20211326 T HR P20211326T HR P20211326 T1 HRP20211326 T1 HR P20211326T1
Authority
HR
Croatia
Prior art keywords
tetrazol
benzenesulfonamide
hydroxyethyl
methyl
ylmethyl
Prior art date
Application number
HRP20211326TT
Other languages
English (en)
Croatian (hr)
Inventor
Carlos Alemparte-Gallardo
Lourdes ENCINAS
Jorge ESQUIVIAS PROVENCIO
Original Assignee
Glaxosmithkline Intellectual Property Development Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Intellectual Property Development Limited filed Critical Glaxosmithkline Intellectual Property Development Limited
Publication of HRP20211326T1 publication Critical patent/HRP20211326T1/hr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/041,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/061,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04Five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HRP20211326TT 2017-08-17 2018-08-16 Novi spojevi tetrazola i njihova primjena u liječenju tuberkuloze HRP20211326T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17382574 2017-08-17
EP18755815.0A EP3668856B1 (en) 2017-08-17 2018-08-16 Novel tetrazole compounds and their use in the treatment of tuberculosis
PCT/EP2018/072205 WO2019034729A1 (en) 2017-08-17 2018-08-16 NOVEL TETRAZOLE COMPOUNDS AND THEIR USE IN THE TREATMENT OF TUBERCULOSIS

Publications (1)

Publication Number Publication Date
HRP20211326T1 true HRP20211326T1 (hr) 2021-11-26

Family

ID=59713960

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20211326TT HRP20211326T1 (hr) 2017-08-17 2018-08-16 Novi spojevi tetrazola i njihova primjena u liječenju tuberkuloze

Country Status (19)

Country Link
US (1) US11072591B2 (https=)
EP (1) EP3668856B1 (https=)
JP (1) JP7410017B2 (https=)
KR (1) KR102661367B1 (https=)
CN (1) CN110997651B (https=)
AU (1) AU2018317812C1 (https=)
CA (1) CA3072854A1 (https=)
CY (1) CY1124577T1 (https=)
DK (1) DK3668856T3 (https=)
ES (1) ES2885573T3 (https=)
HR (1) HRP20211326T1 (https=)
HU (1) HUE055732T2 (https=)
LT (1) LT3668856T (https=)
PL (1) PL3668856T3 (https=)
PT (1) PT3668856T (https=)
RS (1) RS62267B1 (https=)
SI (1) SI3668856T1 (https=)
SM (1) SMT202100515T1 (https=)
WO (1) WO2019034729A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111184718A (zh) * 2018-11-15 2020-05-22 鲁南制药集团股份有限公司 法罗培南在制备治疗初治病原学阳性肺结核药物中的用途
CN115403533B (zh) * 2021-05-28 2023-08-25 永康市第一人民医院 一种1-苯乙烯基-1,2,3-三氮唑化合物及其制备方法和应用
CN116102483B (zh) * 2021-11-09 2025-01-17 中国医学科学院药物研究所 取代吡咯-2,5-二酮类化合物及其制备方法和用途
CN116726018A (zh) * 2023-08-02 2023-09-12 上海市肺科医院(上海市职业病防治院) 一种贝达喹啉、德拉马尼、氯法齐明和吡嗪酰胺的联用和应用
CN117379430A (zh) * 2023-10-11 2024-01-12 深圳市第三人民医院(深圳市肝病研究所) 一种地拉韦啶的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3621427B2 (ja) 1997-07-22 2005-02-16 塩野義製薬株式会社 糸球体障害治療または予防剤
KR20120003499A (ko) * 2007-04-05 2012-01-10 지멘스 메디컬 솔루션즈 유에스에이, 인크. 클릭 화학을 이용한 탄산탈수효소―ⅰⅹ에 대한 분자 영상화 프로브의 제조
WO2017066964A1 (en) 2015-10-22 2017-04-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents

Also Published As

Publication number Publication date
EP3668856B1 (en) 2021-06-23
WO2019034729A1 (en) 2019-02-21
BR112020003247A2 (pt) 2020-08-18
JP2020531425A (ja) 2020-11-05
CA3072854A1 (en) 2019-02-21
ES2885573T3 (es) 2021-12-14
CN110997651A (zh) 2020-04-10
SMT202100515T1 (it) 2021-11-12
PL3668856T3 (pl) 2021-12-13
CY1124577T1 (el) 2022-07-22
RU2020110818A (ru) 2021-09-17
EP3668856A1 (en) 2020-06-24
US20200231555A1 (en) 2020-07-23
RS62267B1 (sr) 2021-09-30
US11072591B2 (en) 2021-07-27
KR20200041915A (ko) 2020-04-22
JP7410017B2 (ja) 2024-01-09
CN110997651B (zh) 2023-01-03
PT3668856T (pt) 2021-09-15
AU2018317812B2 (en) 2021-04-15
DK3668856T3 (da) 2021-09-20
HUE055732T2 (hu) 2021-12-28
RU2020110818A3 (https=) 2021-10-11
AU2018317812A1 (en) 2020-02-20
AU2018317812C1 (en) 2021-08-26
KR102661367B1 (ko) 2024-04-29
SI3668856T1 (sl) 2021-11-30
LT3668856T (lt) 2021-09-27

Similar Documents

Publication Publication Date Title
HRP20211326T1 (hr) Novi spojevi tetrazola i njihova primjena u liječenju tuberkuloze
JP7330312B2 (ja) Hivを治療するためのトール様受容体の調節因子
JP2020531425A5 (https=)
US11352329B2 (en) HIV protease inhibitors
NZ716350A (en) Tricyclic benzoxaborole compounds and uses thereof
CN106749272B (zh) 用于抗病毒治疗的2’-取代的卡巴-核苷类似物
JP2015501845A5 (https=)
ME02570B (me) Farmaceutska kompozicija koja sadrži ne-nukleozidni inhibitor reverzne transkriptaze
RU2006137555A (ru) Способы и композиции для лечения вич-инфекции
MX2020014163A (es) Formas solidas y formulaciones de (s)-4-(8-amino-3-(1-(but-2-inoil )pirrolidin-2-il)imidazo [1,5-a]pirazin-1-il)-n-(piridin-2-il)benz amida.
JP2016527321A5 (https=)
JP2017516797A (ja) 組み合わせ
JP2019511542A5 (https=)
HRP20211172T1 (hr) Derivati kinolina za uporabu u liječenju ili prevenciji virusne infekcije
AU2019270394A1 (en) Substituted condensed thiophenes as modulators of sting
IL272562B2 (en) Compounds or pharmaceutically acceptable salts thereof for the treatment of mycobacterial infection
US20180296505A1 (en) Booster drug therapy for mycobacterium infections
HRP20201780T1 (hr) Prolijekovi inhibitora hiv reverzne transkriptaze
HRP20201597T1 (hr) 4-supstituirani spojevi benzoksaborola i njihova upotreba
JP2020519592A5 (https=)
HRP20211894T1 (hr) Novi spojevi
RU2020110521A (ru) Новые соединения
Meyer et al. Inhalative vaccination with pneumococcal polysaccharide in patients with chronic obstructive pulmonary disease
CN113214262B (zh) 一种含有胍基的化合物及其制备方法和用途
EP4387977A1 (en) Phospholipid compounds and methods of making and using the same