CN110603037A - 普那布林的组合物及其用途 - Google Patents

普那布林的组合物及其用途 Download PDF

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Publication number
CN110603037A
CN110603037A CN201880029191.0A CN201880029191A CN110603037A CN 110603037 A CN110603037 A CN 110603037A CN 201880029191 A CN201880029191 A CN 201880029191A CN 110603037 A CN110603037 A CN 110603037A
Authority
CN
China
Prior art keywords
inhibitors
inhibitor
plinabulin
immunotherapy
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880029191.0A
Other languages
English (en)
Chinese (zh)
Inventor
雷蒙·穆汗拉尔
黄岚
乔治·肯尼斯·劳埃德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DALIAN WANCHUN BIOTECHNOLOGY Co Ltd
Original Assignee
DALIAN WANCHUN BIOTECHNOLOGY Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DALIAN WANCHUN BIOTECHNOLOGY Co Ltd filed Critical DALIAN WANCHUN BIOTECHNOLOGY Co Ltd
Publication of CN110603037A publication Critical patent/CN110603037A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201880029191.0A 2017-03-13 2018-03-12 普那布林的组合物及其用途 Pending CN110603037A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762470802P 2017-03-13 2017-03-13
US62/470,802 2017-03-13
US201862621528P 2018-01-24 2018-01-24
US62/621,528 2018-01-24
PCT/US2018/022064 WO2018169887A1 (en) 2017-03-13 2018-03-12 Compositions of plinabulin and use thereof

Publications (1)

Publication Number Publication Date
CN110603037A true CN110603037A (zh) 2019-12-20

Family

ID=63522552

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880029191.0A Pending CN110603037A (zh) 2017-03-13 2018-03-12 普那布林的组合物及其用途

Country Status (13)

Country Link
US (1) US20200129504A1 (https=)
EP (2) EP3595653B1 (https=)
JP (3) JP7280192B2 (https=)
KR (1) KR102659907B1 (https=)
CN (1) CN110603037A (https=)
AU (2) AU2018236168B2 (https=)
BR (1) BR112019018880A2 (https=)
CA (1) CA3056077A1 (https=)
DK (1) DK3595653T3 (https=)
ES (1) ES2942889T3 (https=)
NZ (2) NZ778329A (https=)
SG (1) SG11201908420WA (https=)
WO (1) WO2018169887A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113456643A (zh) * 2021-08-11 2021-10-01 遵义医科大学 一种含普那布林的药物组合及其应用
WO2024078529A1 (zh) * 2022-10-11 2024-04-18 大连万春布林医药有限公司 一种普那布林胶束组合物及其制备方法

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HK1249051A1 (zh) 2015-03-06 2018-10-26 BeyondSpring Pharmaceuticals Inc. 治疗脑肿瘤的方法
MX383691B (es) 2015-03-06 2025-03-14 Beyondspring Pharmaceuticals Inc Método de tratamiento de cáncer asociado con una mutación de ras.
US10155748B2 (en) 2015-07-13 2018-12-18 Beyondspring Pharmaceuticals, Inc. Plinabulin compositions
WO2017139231A1 (en) 2016-02-08 2017-08-17 Beyondspring Pharmaceuticals, Inc. Compositions containing tucaresol or its analogs
RU2760348C2 (ru) 2016-06-06 2021-11-24 Бейондспринг Фармасьютикалс, Инк. Способ уменьшения нейтропении
JP2020503363A (ja) 2017-01-06 2020-01-30 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド チューブリン結合化合物およびその治療的使用
BR112019015974A2 (pt) 2017-02-01 2020-03-31 Beyondspring Pharmaceuticals, Inc. Método para reduzir neutropenia
GB201713760D0 (en) * 2017-08-28 2017-10-11 Univ Leuven Kath Treatment of epilepsy
KR20200112881A (ko) 2018-01-24 2020-10-05 비욘드스프링 파마수티컬스, 인코포레이티드. 플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법
ES3060133T3 (en) * 2018-06-01 2026-03-25 Beyondspring Pharmaceuticals Inc Composition and method of treating cancer associated with egfr mutation
GB201913988D0 (en) * 2019-09-27 2019-11-13 Celleron Therapeutics Ltd Novel treatment
EP4045046A4 (en) * 2019-10-15 2024-01-10 Beyondspring Pharmaceuticals Inc. Methods and compositions for treating iron disorders
KR20230006568A (ko) * 2020-05-04 2023-01-10 비욘드스프링 파마수티컬스, 인코포레이티드. 낮은 면역원성을 갖는 암에서 암세포 사멸을 강화하기 위한 삼중 병용 요법
KR102428863B1 (ko) * 2020-08-11 2022-08-03 서울대학교병원 자가면역 뇌염 발생 가능성 예측을 위한 정보 제공 방법
WO2022133492A1 (en) * 2020-12-18 2022-06-23 Beyondspring Pharmaceuticals, Inc. Compositions and methods for generating anti-tumor immune response
CA3215047A1 (en) 2021-04-09 2022-10-13 Lan Huang Therapeutic compositions and methods for treating tumors
AU2023219702A1 (en) * 2022-02-10 2024-09-05 Beyondspring Pharmaceuticals, Inc. Stable plinabulin formulations and methods of their preparation and use
WO2025006507A1 (en) * 2023-06-27 2025-01-02 Beyondspring Pharmaceuticals, Inc. Oncology combination therapy and methods of use

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US20050197344A1 (en) * 2003-08-01 2005-09-08 Palladino Michael A. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
CN101237838A (zh) * 2005-06-17 2008-08-06 康宾纳特克斯公司 治疗免疫炎性疾病的联合疗法

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US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
US4919934A (en) 1989-03-02 1990-04-24 Richardson-Vicks Inc. Cosmetic sticks
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
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US7919497B2 (en) * 2002-08-02 2011-04-05 Nereus Pharmaceuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
BR0313363A (pt) * 2002-08-02 2005-08-09 Nereus Pharmaceuticals Inc Deidrofenilahistinas e seus análogos, e sua sìntese
EP1711487A1 (en) * 2004-02-04 2006-10-18 Nereus Pharmaceuticals, Inc. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
EP1926724A1 (en) * 2005-09-21 2008-06-04 Nereus Pharmaceuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
WO2012035436A1 (en) * 2010-09-15 2012-03-22 Tokyo University Of Pharmacy And Life Sciences Plinabulin prodrug analogs and therapeutic uses thereof
JP6311097B2 (ja) * 2013-07-31 2018-04-18 学校法人東京薬科大学 微小管脱重合剤
JP6411523B2 (ja) * 2013-10-11 2018-10-24 ビヨンドスプリング インコーポレイテッド プリナブリン及びタキサンの組合せがん治療
AU2016219204B2 (en) * 2015-02-12 2021-01-21 Beyondspring Pharmaceuticals, Inc. Use of Plinabulin in combination with immune checkpoint inhibitors
WO2017139231A1 (en) * 2016-02-08 2017-08-17 Beyondspring Pharmaceuticals, Inc. Compositions containing tucaresol or its analogs

Patent Citations (2)

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US20050197344A1 (en) * 2003-08-01 2005-09-08 Palladino Michael A. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
CN101237838A (zh) * 2005-06-17 2008-08-06 康宾纳特克斯公司 治疗免疫炎性疾病的联合疗法

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113456643A (zh) * 2021-08-11 2021-10-01 遵义医科大学 一种含普那布林的药物组合及其应用
CN113456643B (zh) * 2021-08-11 2022-04-01 遵义医科大学 一种含普那布林的药物组合及其应用
WO2024078529A1 (zh) * 2022-10-11 2024-04-18 大连万春布林医药有限公司 一种普那布林胶束组合物及其制备方法

Also Published As

Publication number Publication date
SG11201908420WA (en) 2019-10-30
KR102659907B1 (ko) 2024-04-24
DK3595653T3 (da) 2023-04-17
EP4190326A1 (en) 2023-06-07
US20200129504A1 (en) 2020-04-30
JP2020520889A (ja) 2020-07-16
NZ757213A (en) 2022-01-28
JP2025138849A (ja) 2025-09-25
ES2942889T3 (es) 2023-06-07
AU2018236168B2 (en) 2024-02-29
EP3595653A4 (en) 2020-11-11
JP2023099217A (ja) 2023-07-11
KR20190122822A (ko) 2019-10-30
AU2024200709A1 (en) 2024-02-22
BR112019018880A2 (pt) 2020-04-14
EP3595653B1 (en) 2023-03-08
AU2018236168A1 (en) 2019-10-10
JP7280192B2 (ja) 2023-05-23
CA3056077A1 (en) 2018-09-20
NZ778329A (en) 2026-03-27
WO2018169887A1 (en) 2018-09-20
EP3595653A1 (en) 2020-01-22

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