CN110573605A - 一种慢生根瘤菌单加氧酶及其在制备手性亚砜中的应用 - Google Patents

一种慢生根瘤菌单加氧酶及其在制备手性亚砜中的应用 Download PDF

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CN110573605A
CN110573605A CN201880003603.3A CN201880003603A CN110573605A CN 110573605 A CN110573605 A CN 110573605A CN 201880003603 A CN201880003603 A CN 201880003603A CN 110573605 A CN110573605 A CN 110573605A
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amino acid
acid sequence
monooxygenase
seq
botemo
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CN110573605B (zh
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郁惠蕾
张龑
许建和
赵骞
潘江
刘峰
林国强
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East China University of Science and Technology
Shanghai Institute of Materia Medica of CAS
Jiangsu Aosaikang Pharmaceutical Co Ltd
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Shanghai Institute of Materia Medica of CAS
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Abstract

一种慢生根瘤菌单加氧酶、编码该酶的基因、含有该基因的重组表达载体和重组表达转化体，利用重组表达转化体制备所述单加氧酶的方法，以及利用所述单加氧酶制备光学纯手性亚砜，特别是催化拉唑类前体硫醚不对称氧化制备拉唑类药物的方法。

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PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN201880003603.3A 2018-03-08 2018-04-13 一种慢生根瘤菌单加氧酶及其在制备手性亚砜中的应用 Active CN110573605B (zh)

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CN2018101918273 2018-03-08
PCT/CN2018/083060 WO2019169695A1 (zh) 2018-03-08 2018-04-13 一种慢生根瘤菌单加氧酶及其在制备手性亚砜中的应用

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Cited By (2)

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CN112481224A (zh) * 2020-11-27 2021-03-12 江南大学 一种Baeyer-Villiger单加氧酶及其应用
CN114836395A (zh) * 2022-04-28 2022-08-02 华东理工大学 硫醚单加氧酶突变体及其在制备手性拉唑药物中的应用

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* Cited by examiner, † Cited by third party
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CN111218431A (zh) * 2018-11-26 2020-06-02 华东理工大学 一种单加氧酶及其在制备光学纯亚砜中的应用
CN112410312A (zh) * 2020-11-27 2021-02-26 江南大学 一种环己酮单加氧酶及其应用
CN112725297B (zh) * 2021-01-29 2023-12-29 华东理工大学 一种硫醚单加氧酶及其在制备手性拉唑药物中的应用
CN113430216B (zh) * 2021-07-26 2023-07-21 福州大学 一种苯丙酮单加氧酶及在拉唑类药物制备中的应用
CN115305243B (zh) * 2022-06-28 2023-06-02 江南大学 一种Baeyer-Villiger单加氧酶突变体及其应用

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CN104560905A (zh) * 2015-01-21 2015-04-29 遵义医学院 一种源自假单胞菌的硫醚单加氧酶及其合成应用
CN104673764A (zh) * 2015-01-21 2015-06-03 遵义医学院 一种硫醚单加氧酶pmo-3546及其应用
WO2016050819A1 (en) * 2014-09-30 2016-04-07 Basf Se Method for preparing an acrylamide solution having a low acrylic acid concentration

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US7105296B2 (en) * 2001-08-29 2006-09-12 E. I. Du Pont De Nemours And Company Genes encoding Baeyer-Villiger monooxygenases
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CN102206671A (zh) * 2010-03-26 2011-10-05 中国科学院上海生命科学研究院 一种改变植物性状的方法
WO2016050819A1 (en) * 2014-09-30 2016-04-07 Basf Se Method for preparing an acrylamide solution having a low acrylic acid concentration
CN104560905A (zh) * 2015-01-21 2015-04-29 遵义医学院 一种源自假单胞菌的硫醚单加氧酶及其合成应用
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112481224A (zh) * 2020-11-27 2021-03-12 江南大学 一种Baeyer-Villiger单加氧酶及其应用
CN114836395A (zh) * 2022-04-28 2022-08-02 华东理工大学 硫醚单加氧酶突变体及其在制备手性拉唑药物中的应用
CN114836395B (zh) * 2022-04-28 2024-04-26 华东理工大学 硫醚单加氧酶突变体及其在制备手性拉唑药物中的应用

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US20200140830A1 (en) 2020-05-07
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WO2019169695A1 (zh) 2019-09-12
US10787651B2 (en) 2020-09-29

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