CN110573499B - αvβ6整合蛋白的抑制剂 - Google Patents

αvβ6整合蛋白的抑制剂 Download PDF

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CN110573499B
CN110573499B CN201880028013.6A CN201880028013A CN110573499B CN 110573499 B CN110573499 B CN 110573499B CN 201880028013 A CN201880028013 A CN 201880028013A CN 110573499 B CN110573499 B CN 110573499B
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compound
mmol
naphthyridin
tetrahydro
esi
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CN110573499A (zh
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M.布鲁尔
M.G.伯萨维奇
A.L.格拉斯余托
K.N.哈恩
B.A.哈里森
K.D.孔策
林富扬
B.S.利帕
A.A.卢戈夫斯科
B.N.罗杰斯
M.A.斯文森
D.M.特罗亚斯特
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Murphy Medical Co ltd
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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CN201880028013.6A 2017-02-28 2018-02-27 αvβ6整合蛋白的抑制剂 Active CN110573499B (zh)

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US201762464693P 2017-02-28 2017-02-28
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EP (2) EP4159727B1 (https=)
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KR (2) KR102891803B1 (https=)
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AR (2) AR111009A1 (https=)
AU (4) AU2018229275B2 (https=)
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US12459942B2 (en) 2018-08-29 2025-11-04 Morphic Therapeutic, Inc. Inhibiting (α-v)(β-6) integrin
US12552786B2 (en) * 2018-08-29 2026-02-17 Morphic Therapeutic, Inc. Inhibitors of αvβ6 integrin

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CN109996541A (zh) 2016-09-07 2019-07-09 普利安特治疗公司 N-酰基氨基酸化合物及其使用方法
USRE50554E1 (en) 2016-12-23 2025-08-26 Pliant Therapeutics, Inc. Amino acid compounds and methods of use
MA52117A (fr) 2017-02-28 2022-04-06 Morphic Therapeutic Inc Inhibiteurs de l'intégrine (alpha-v) (bêta-6)
MA47697A (fr) 2017-02-28 2020-01-08 Morphic Therapeutic Inc Inhibiteurs de l'(alpha-v)(bêta-6) intégrine
PL3761980T3 (pl) 2018-03-07 2024-06-10 Pliant Therapeutics, Inc. Związki aminokwasowe i sposoby zastosowania
TWI841573B (zh) 2018-06-27 2024-05-11 美商普萊恩醫療公司 具有未分支連接子之胺基酸化合物及使用方法
WO2020047207A1 (en) 2018-08-29 2020-03-05 Morphic Therapeutics, Inc. Inhibitors of (alpha-v)(beta-6) integrin
FI3844162T3 (fi) 2018-08-29 2025-03-27 Morphic Therapeutic Inc Alfa v beeta6 -integriinin estäjiä
TW202028179A (zh) 2018-10-08 2020-08-01 美商普萊恩醫療公司 胺基酸化合物及使用方法
AU2019373242B2 (en) 2018-10-30 2023-07-13 Gilead Sciences, Inc. Compounds for inhibition of alpha 4 beta 7 integrin
EP4541422A3 (en) 2018-10-30 2025-06-25 Gilead Sciences, Inc. Quinoline derivatives as alpha4beta7 integrin inhibitors
KR102659859B1 (ko) 2018-10-30 2024-04-25 길리애드 사이언시즈, 인코포레이티드 알파4β7 인테그린의 억제를 위한 화합물
CN112969700B (zh) 2018-10-30 2024-08-20 吉利德科学公司 作为α4β7整合素抑制剂的咪唑并吡啶衍生物
US11419869B2 (en) 2019-04-08 2022-08-23 Pliant Therapeutics, Inc. Dosage forms and regimens for amino acid compounds
KR102908219B1 (ko) 2019-08-14 2026-01-08 길리애드 사이언시즈, 인코포레이티드 알파 4 베타 7 인테그린의 저해용 화합물
WO2021076890A1 (en) * 2019-10-16 2021-04-22 Morphic Therapeutic, Inc. INHIBITING HUMAN INTEGRIN α4β7
CN111718250B (zh) * 2020-06-28 2022-04-22 万华化学集团股份有限公司 一种制备r-香茅醛的方法
EP4247472A4 (en) 2020-11-19 2024-10-09 Pliant Therapeutics, Inc. INTEGRIN INHIBITORS AND USES THEREOF
EP4665339A1 (en) * 2023-02-14 2025-12-24 Morphic Therapeutic, Inc. Inhibiting alpha v beta 8 integrin
JP2026506655A (ja) * 2023-02-14 2026-02-25 モーフィック セラピューティック，インコーポレイテッド αｖβ８インテグリンの阻害
TW202537962A (zh) * 2023-11-15 2025-10-01 美商莫菲克醫療股份有限公司 抑制α-V β-1整合素

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