CN110496144A - A kind of Kiwi extract preparation method and its application for preventing and treating cardiovascular and cerebrovascular disease - Google Patents
A kind of Kiwi extract preparation method and its application for preventing and treating cardiovascular and cerebrovascular disease Download PDFInfo
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The present invention relates to plant and its applied technical field, Kiwi extract preparation method includes preparing extracting solution, precipitating, removal of impurities, decoloration, drying, crushing, obtains Kiwi extract dry product；The present invention uses kiwifruit fruit, leaf, branch and root extract as the application in prevention and treatment cardiovascular and cerebrovascular disease, because fruit has the prevention and treatment AS drug effect such as blood pressure lowering, blood lipid, anti-oxidant, anti-inflammatory, improvement hemorheology；Root has antitumor, anti-inflammatory, antiviral, anti-mutation, anti-oxidant and liver protection, improves the various actives such as immunity, reducing blood lipid；The medicinal parts such as root, stem, fruit all have antitumor action and hepatoprotective effect.
Description
Technical field
The present invention relates to plant and its applied technical fields, and in particular to a kind of Kiwi extract preparation method and its anti-
Control the application of cardiovascular and cerebrovascular disease.
Background technique
Cardiovascular and cerebrovascular disease (CVD) is the general designation of cardiovascular disease and cranial vascular disease, and main pathological basis is artery
Atherosis (atherosclerosis, AS)；Common cardiovascular and cerebrovascular disease includes cranial vascular disease, coronary disease in Modern human populations
Disease, myocardial infarction, apoplexy, rheumatic heart disease and cor pulmonale etc..Cardiovascular and cerebrovascular disease is to seriously threaten mankind nowadays
The disease of life and health, it has also become the one or two cause of death of world's most countries；According to World Health Organization's recent statistics knot
Fruit, in the past decade global ten big cause of the death front twos is coronary heart disease and apoplexy respectively；During Chinese residents cause of disease death is constituted
Cardiovascular and cerebrovascular diseases account for 41.1% in city dweller, account for 38.7% in rural resident, are the number one killers of China resident.
It is hyperlipidemia, smoking, hypertension, diabetes, obesity, generation that doctor trained in Western medicine, which thinks to cause the risk factor of cardiovascular and cerebrovascular disease,
Thank syndrome, oxidative stress, infection and inflammatory reaction etc..In addition to some samples illness such as myocarditis and rheumatic heart
It is sick outer, needed during the alleviation very long after the acute onset of most of cardiovascular and cerebrovascular disease continual drug therapy to prevent
Only cardiovascular and cerebrovascular disease recurs.Chemical drugs and biological medicament effect are direct, rapid, but action and efficacy is single, toxic side effect is big, uncomfortable
Close long-term conditioning and treatment；And Chinese medicine has many advantages, such as " multiple target point, manifold effect, toxic side effect are small ", prevents and treats cardiovascular and cerebrovascular disease
Disease advantageously, is suitble to take for a long time.
Kiwi berry (Actinidia chinensis) fruit is sweet in flavor, sour, cold in nature, enters spleen, stomach meridian, and real heat person preferably eats it, tool
There are regulating QI of the middle-JIAO, only sudden and violent thirsty, solution dysphoria with smothery sensation, the heap soil or fertilizer over and around the roots of lower urolithiasis heat and other effects；Complete stool is lightly seasoned, puckery, mild-natured, heat-clearing poison.Kiwi berry is in
There is plantation in many places of state, and wherein red kiwifruit is some national poor in Guangxi, Guizhou etc. as a poverty alleviation industry
Area completes the plantation of large area.However Kiwi berry is not easy fresh-keeping, thin skin, long-distance transport is easy to damage to lead to this 2 years a large amount of Mi
It is the product overloading of monkey peach, unsalable, extreme loss is caused to farmer, resident has been given a heavy blow to and has planted enthusiasm.Though there is use at present
Kiwifruit fruit peeling is pressed into preserved fruit after drying, and kiwifruit fruit fermentation or is formulated the special of beverage or health care product with other medicinal materials
Benefit, but lack medicinal, healthy nutritive value the research of its product and it is caused to be difficult to promote, produce, Kiwi berry can not be solved
It overstocks and unsalable problem.
Therefore, national medicine should be sufficiently excavated for the prevention and treatment of cardiovascular and cerebrovascular disease, is faced for Kiwi berry planting industry
Predicament should sufficiently excavate each position medical value of Kiwi berry, research and development have few side effects, it is at low cost, easy absorb, processing letter,
Each position of the Kiwi berry easily promoted formula, thus cardiovascular and cerebrovascular disease prevent, treat and Kiwi berry economic value on all take
Obtain more preferable effect.
Summary of the invention
The purpose of the present invention is to provide a kind of Kiwi extract and preparation method thereof for improving cardiovascular and cerebrovascular disease and
Purposes, to solve the problems, such as proposed in above-mentioned background technique.
To achieve the above object, the invention provides the following technical scheme:
A kind of Kiwi extract preparation method, comprising the following steps:
(A), extracting solution is prepared
Kiwifruit fruit, leaf, branch and root are cleaned into the flat grinds of mixing, coarse powder 1Kg is taken, successively uses 90%, 50% and
20-60 DEG C of ethyl alcohol of 10% impregnates 3 times, 18-30 hours each, takes supernatant, merges；
The drug effect at each position of Kiwi berry:
Fruit is sweet in flavor, sour, cold, nontoxic, enters spleen, stomach meridian, and real heat person preferably eats it, and with regulating QI of the middle-JIAO, only sudden and violent thirsty, solution is tired of
Hot, lower urolithiasis heat heap soil or fertilizer over and around the roots and other effects；Root has effects that heat-clearing, diuresis, promoting blood circulation, detumescence；Juice is sweet, sliding, cold, nontoxic, lower urolithiasis, with
Ginger juice clothes control heat and stop up gastric disorder causing nausea；Branches and leaves desinsection treats Guo scabies；Complete stool is lightly seasoned, puckery, mild-natured, heat-clearing poison.
Modern pharmacology research the result shows that, fruit have blood pressure lowering, blood lipid, it is anti-oxidant, anti-inflammatory, improve hemorheology etc.
Prevent and treat AS drug effect；Root has antitumor, anti-inflammatory, antiviral, anti-mutation, anti-oxidant and liver protection, raising immunity, reducing blood lipid etc. more
Kind activity；The medicinal parts such as root, stem, fruit all have antitumor action and hepatoprotective effect.
(B), it precipitates
In the extracting solution of step (A) plus ethyl alcohol is adjusted to containing amount of alcohol be 90-95%, stands, centrifugal treating is clarified
Liquid；Sediment respectively washs 2 times and centrifugal treating with the second alcohol and water of 50-80% again, and clarified solution is taken to abandon precipitating；
(C), it cleans, decolourize
Active carbon is added in (B) clarified solution: atlapulgite=1:10 mixing decolorising agent 2000g removal of impurities decoloration, decoloration
Solution is in pole pistac afterwards；
(D), dry, crushing
Clarified solution after decoloration is concentrated under reduced pressure in vacuum concentration equipment with 50-55 DEG C, it is dry that concentrate is put into decompression
It in dry case, is dried under reduced pressure under the conditions of 40-58 DEG C about 48 hours, vacuum degree is -0.08 to -0.1MPa, obtains Kiwi berry extraction
Object dry product.
Further, the dosage of each ratio ethyl alcohol is 5 liters in the step (A), is stirred in dipping process every two hours
It mixes once, mixing time is 15 minutes, is filtered after the completion of dipping, collection supernatant.
Further, vacuum degree is -0.06 to -0.05MPa in step (D), maintains the temperature at 50-55 DEG C, and 12-15 is concentrated
Times.
Vacuum degree is -0.55MPa in step (D), maintains the temperature at 55 DEG C, is concentrated 13 times.
In the present invention, a kind of Kiwi extract is prepared using the above method.Kiwi berry of the present invention mentions
Take object in the application of prevention and treatment cardiovascular and cerebrovascular disease.
Compared with prior art, the beneficial effects of the present invention are:
The present invention uses kiwifruit fruit, leaf, branch and root extract as the application in prevention and treatment cardiovascular and cerebrovascular disease, because
Fruit has the prevention and treatment AS drug effect such as blood pressure lowering, blood lipid, anti-oxidant, anti-inflammatory, improvement hemorheology；Root has antitumor, anti-inflammatory, anti-
Viral, anti-mutation, improves the various actives such as immunity, reducing blood lipid at anti-oxidant and liver protection；The medicinal parts such as root, stem, fruit all have
There are antitumor action and hepatoprotective effect；Each position of Kiwi berry, which shares, embodies Chinese medicine the monarch and his subjects assistant history compatibility thought, and similar drug effect is added
Such a multicomponent is complementary to one another with foreign peoples's drug effect, multiple target point, synergistic effect enhancing reducing blood lipid, improves hemorheology, anti-
The prevention and treatment cardiovascular and cerebrovascular disease drug effect such as scorching, anti-oxidant.
Each position of Kiwi berry be the drug that is easy to get is commonly used in traditional Chinese medicine, and it is low in cost, the processing is simple.According to conditions of patients
And need can be processed into pill, decoction, it is easy to take；Meanwhile passing through reducing blood lipid, improvement blood for the cardiovascular and cerebrovascular disease cause of disease
The various aspects prevention and treatment such as rheology, anti-inflammatory, anti-oxidant, strengthen immunity；Medicinal material used belongs to natural drug and each position
Nontoxic, medicinal peace after compatibility, body heat, cold body person can take for a long time, avoid taking chemical synthetic drug bring for a long time
Side effect and drug resistance meet cardiovascular disease prevention Medicinal Trait.
Detailed description of the invention
Fig. 1 is extract of the present invention for preventing and treating cardiovascular and cerebrovascular disease experimental result.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that the described embodiment is only a part of the embodiment of the present invention, instead of all the embodiments.Based on this
Embodiment in invention, every other reality obtained by those of ordinary skill in the art without making creative efforts
Example is applied, shall fall within the protection scope of the present invention.
Embodiment 1: preparation is to Kiwi berry whole strain extract:
(A), extracting solution is prepared
Kiwifruit fruit, leaf, branch and root are cleaned into the flat grinds of mixing, coarse powder 1Kg is taken, successively uses 90%, 50% and
20-60 DEG C of ethyl alcohol of 10% impregnates 3 times, 18-30 hours each, takes supernatant, merges；
(B), it precipitates
In the extracting solution of step (A) plus ethyl alcohol is adjusted to containing amount of alcohol be 90-95%, stands, centrifugal treating is clarified
Liquid；Sediment respectively washs 2 times and centrifugal treating with the second alcohol and water of 50-80% again, and clarified solution is taken to abandon precipitating；
(C), it cleans, decolourize
Active carbon is added in (B) clarified solution: atlapulgite=1:10 mixing decolorising agent 2000g removal of impurities decoloration, decoloration
Solution is in pole pistac afterwards；
(D), dry, crushing
Clarified solution after decoloration is concentrated under reduced pressure in vacuum concentration equipment with 50-55 DEG C, it is dry that concentrate is put into decompression
It in dry case, is dried under reduced pressure under the conditions of 40-58 DEG C about 48 hours, vacuum degree is -0.08 to -0.1MPa, obtains Kiwi berry extraction
Object dry product.
Embodiment 2: being dried under reduced pressure about 48 hours under the conditions of 58 DEG C, and vacuum degree is -0.55MPa, maintains the temperature at 55 DEG C,
13 times of concentration, remaining is same as Example 1.
Embodiment 3: to the pharmacodynamic experiment of Kiwi berry whole strain extract:
1. experimental animal: clean type new zealand rabbit 24, half male and half female, weight (2.25 ± 0.25) kg, divide blank group,
Experimental group and model group, every group 8, single cage raising.Quail 30, clean type Huang plumage system, 5 week old, half male and half female, weight (90 ±
20) g divides blank group, experimental group and model group, and every group 10, every group of cage is raised.
2. prepared by high lipid food: quail high lipid food formula is cholesterol 1%, peanut oil 6%, lard 14%, basis feeding
Material 79%.Rabbit high lipid food formula is 1.0% cholesterol, 8% lard, 4% yolk powder, 87.0% basal feed.
3. test method: each position of Kiwi berry mix according to a certain percentage after successively using 90% ethyl alcohol, 50% ethyl alcohol and
Extracting in boiling water, each gradient extracting solution are mixed and are concentrated under reduced pressure, blank group feeding chow diet；Experimental group feeding high lipid food parallel port
Take extract of the present invention；Model group feeding high lipid food；Quail feeding amount is not fixed, the daily every feeding 120g of rabbit；Quail
Model is daily by 2.50ml/kg (being equivalent to 3g whole strain extract/kg) extract 1 time of the present invention, continuous raising 42 days；Rabbit mould
Type presses 7.3g extract/only administration, continuous raising 60 days daily.Experiment takes haemanalysis blood respectively at experiment 0 and 60d auricular vein
The physiochemical indices such as five, rouge, hemorheology, SOD, experiment terminates auricular vein and takes the lower dissection animal of urethane anesthesia after blood, fast
Speed takes out heart and aorta；Aorta is cut from the position that heart is connect with aorta and common iliac artery bifurcation, after in vitro
Longitudinal direction cuts off aorta and removes tunica adventitia of artery, and sample gives 10% neutral formalin solution and fixes, to Sudan IV dyeing and disease
Reason checks.
Experimental result is referring to table 1, table 2, table 3, table 4 and Fig. 1, through statistical analysis, is extracted as the result is shown using the present invention
Object is above normal group to quail, rabbit triglycerides, total cholesterol, low-density lipoprotein but significantly lower than model group and it is poor
It is different to all have statistical significance, show that this drug has preferable effect for reducing blood fat；Hemorheology index shows that this medicine can be effective
It is most of to reduce rabbit whole blood viscosity and erythrocyte aggregation index etc.；
Influence (mmol/l, x ± s, the n=8) of 1 Kiwi berry complete stool of table to atherosclerotic rabbit SOD and lipid-metabolism
(x ± s normally organizes n=4, other for influence of 2 kiwifruit fruit of table to atherosclerotic rabbit hemorheology
Two groups of n=3)
Influence (mmol/l, x ± s, the n=10) of 3 Kiwi berry complete stool of table to Atherosclerotic Quail lipid-metabolism
Influence (x ± s, the n=10) of 4 Kiwi berry complete stool of table to Atherosclerotic Quail hemorheology
The above is presently preferred embodiments of the present invention and its technical principle used, for those skilled in the art
For, without departing from the spirit and scope of the present invention, any equivalent change based on the basis of technical solution of the present invention
Change, simple replacement etc. is obvious changes, all fall within the protection scope of the present invention.
Claims (6)
1. a kind of Kiwi extract preparation method, it is characterised in that: the following steps are included:
(A), extracting solution is prepared
Kiwifruit fruit, leaf, branch and root are cleaned into the flat grinds of mixing, coarse powder 1Kg is taken, successively uses 90%, 50% and 10%
Ethyl alcohol in 20-60 DEG C impregnate 3 times, it is 18-30 hour each, take supernatant, merging；
(B), it precipitates
In the extracting solution of step (A) plus ethyl alcohol is adjusted to containing amount of alcohol be 90-95%, stands, centrifugal treating obtains clarified solution；
Sediment respectively washs 2 times and centrifugal treating with the second alcohol and water of 50-80% again, and clarified solution is taken to abandon precipitating；
(C), it cleans, decolourize
Active carbon is added in (B) clarified solution: atlapulgite=1:10 mixing decolorising agent 2000g removal of impurities decoloration, it is molten after decoloration
Liquid is in pole pistac；
(D), dry, crushing
Clarified solution after decoloration is concentrated under reduced pressure in vacuum concentration equipment with 50-55 DEG C, concentrate, which is put into, is dried under reduced pressure case
In, it is dried under reduced pressure under the conditions of 40-58 DEG C about 48 hours, vacuum degree is -0.08 to -0.1MPa, and it is dry to obtain Kiwi extract
Product.
2. a kind of Kiwi extract preparation method according to claim 1, it is characterised in that: respectively compare in the step (A)
The dosage of example ethyl alcohol is respectively 5 liters, and primary every two hour stirrings in dipping process, mixing time is 15 minutes, has been impregnated
At rear filtering, supernatant is collected.
3. a kind of Kiwi extract preparation method according to claim 1, it is characterised in that: in step (D) vacuum degree be-
0.06 to -0.05MPa, 50-55 DEG C is maintained the temperature at, is concentrated 12-15 times.
4. a kind of Kiwi extract preparation method according to claim 1, it is characterised in that: in step (D) vacuum degree be-
0.55MPa maintains the temperature at 55 DEG C, is concentrated 13 times.
5. Kiwi extract is made in a kind of preparation method as described in claim 1.
6. a kind of Kiwi extract as claimed in claim 5 is in the application of prevention and treatment cardiovascular and cerebrovascular disease.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101522204A (en) * | 2006-05-05 | 2009-09-02 | 欧博康有限公司 | Kiwi extract |
| CN101584718A (en) * | 2008-05-19 | 2009-11-25 | 中国人民解放军第二军医大学 | Antisepalous kiwi fruit leaf extractive as well as preparation method and application thereof |
| CN103415298A (en) * | 2010-12-07 | 2013-11-27 | 奥斯陆大学 | Cardio-protective agents from kiwifruits |
| CN104825505A (en) * | 2015-04-29 | 2015-08-12 | 中国人民解放军第二军医大学 | Actinidia valvata leaf composition for preventing myocardial ischemia |
-
2019
- 2019-08-14 CN CN201910748101.XA patent/CN110496144A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101522204A (en) * | 2006-05-05 | 2009-09-02 | 欧博康有限公司 | Kiwi extract |
| CN101584718A (en) * | 2008-05-19 | 2009-11-25 | 中国人民解放军第二军医大学 | Antisepalous kiwi fruit leaf extractive as well as preparation method and application thereof |
| CN103415298A (en) * | 2010-12-07 | 2013-11-27 | 奥斯陆大学 | Cardio-protective agents from kiwifruits |
| CN104825505A (en) * | 2015-04-29 | 2015-08-12 | 中国人民解放军第二军医大学 | Actinidia valvata leaf composition for preventing myocardial ischemia |
Non-Patent Citations (2)
| Title |
|---|
| 康大力等: "猕猴桃属植物化学成分及其生物活性研究进展 ", 《中成药》 * |
| 徐一新等: "猕猴桃属植物化学成分和生物活性研究进展 ", 《解放军药学学报》 * |
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Application publication date: 20191126 |