CN110494423A - 乐伐替尼甲磺酸盐的新晶型及其制备方法 - Google Patents
乐伐替尼甲磺酸盐的新晶型及其制备方法 Download PDFInfo
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- CN110494423A CN110494423A CN201880024174.8A CN201880024174A CN110494423A CN 110494423 A CN110494423 A CN 110494423A CN 201880024174 A CN201880024174 A CN 201880024174A CN 110494423 A CN110494423 A CN 110494423A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明提供了乐伐替尼甲磺酸盐的新晶型及其制备方法，含有该晶型的药物组合物，以及该晶型在制备酪氨酸酶抑制剂和治疗甲状腺癌药物制剂中的用途。本发明提供的甲磺酸盐新晶型制备成本优势明显，比现有技术具有一种或多种改进的特性，对未来该药物的优化和开发具有重要价值。
Description
PCT国内申请，说明书已公开。
Claims (7)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2017102770480 | 2017-04-25 | ||
| CN201710277048 | 2017-04-25 | ||
| CN2017109031564 | 2017-09-29 | ||
| CN201710903156 | 2017-09-29 | ||
| PCT/CN2018/083861 WO2018196687A1 (zh) | 2017-04-25 | 2018-04-20 | 乐伐替尼甲磺酸盐的新晶型及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110494423A true CN110494423A (zh) | 2019-11-22 |
| CN110494423B CN110494423B (zh) | 2022-04-26 |
Family
ID=63918030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880024174.8A Expired - Fee Related CN110494423B (zh) | 2017-04-25 | 2018-04-20 | 乐伐替尼甲磺酸盐的新晶型及其制备方法 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN110494423B (zh) |
| WO (1) | WO2018196687A1 (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113533544A (zh) * | 2020-04-16 | 2021-10-22 | 先声药业有限公司 | 一种甲磺酸仑伐替尼的有关物质检测方法 |
| CN114174264A (zh) * | 2020-04-24 | 2022-03-11 | 成都苑东生物制药股份有限公司 | 一种甲磺酸仑伐替尼晶型xi及其制备方法 |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110818634B (zh) * | 2018-08-13 | 2021-11-30 | 上海新礼泰药业有限公司 | 甲磺酸乐伐替尼的精制方法 |
| CN111574359A (zh) * | 2019-02-19 | 2020-08-25 | 愈磐生物科技（苏州）有限公司 | 乐伐替尼-没食子酸共晶晶型及其应用 |
| CN111689897B (zh) * | 2019-03-13 | 2024-02-06 | 齐鲁制药有限公司 | 一种高纯度甲磺酸乐伐替尼晶型c的制备方法 |
| CN109867626A (zh) * | 2019-04-18 | 2019-06-11 | 安礼特（上海）医药科技有限公司 | 一种甲磺酸仑伐替尼多晶型物及其制备方法 |
| CN111825609A (zh) * | 2019-04-22 | 2020-10-27 | 北京康辰药业股份有限公司 | 化合物晶型、其制备方法、药物组合物以及应用 |
| CN110256341A (zh) * | 2019-06-27 | 2019-09-20 | 尚科生物医药（上海）有限公司 | 一种乐伐替尼甲磺酸盐晶型c的制备方法 |
| CN110563644A (zh) * | 2019-10-30 | 2019-12-13 | 北京赛思源生物医药技术有限公司 | 一种仑伐替尼甲磺酸盐的新晶型 |
| US11059787B2 (en) | 2019-11-12 | 2021-07-13 | Shenzhen Bolan Pharmaceutical Co., Ltd | Crystalline form of lenvatinib mesylate and methods thereof |
| CN113135853A (zh) * | 2020-01-19 | 2021-07-20 | 重庆医药工业研究院有限责任公司 | 一种氟伐替尼或甲磺酸盐的晶型及其制备方法 |
| CN111233762B (zh) * | 2020-02-20 | 2021-12-28 | 天津理工大学 | 一种乐伐替尼与对羟基苯甲酸共晶及其制备方法 |
| CN111793027B (zh) * | 2020-08-07 | 2021-12-03 | 天津理工大学 | 一种乐伐替尼与苯甲酸的共晶及其制备方法 |
| CN114213322B (zh) * | 2022-01-05 | 2023-11-07 | 中国药科大学 | 甲磺酸仑伐替尼没食子酸共晶及其制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1890220A (zh) * | 2003-12-25 | 2007-01-03 | 卫材株式会社 | 4－(3－氯－4－(环丙基氨基羰基)氨基苯氧基)－7－甲氧基－6－喹啉羧酰胺的盐或其溶剂合物的结晶及其制备方法 |
| CN101233111A (zh) * | 2005-06-23 | 2008-07-30 | 卫材R&D管理有限公司 | 4-（3-氯-4-（环丙基氨基羰基）氨基苯氧基）-7-甲氧基-6-喹啉羧酸酰胺的无定形盐及其制备方法 |
| WO2016184436A1 (zh) * | 2015-05-21 | 2016-11-24 | 苏州晶云药物科技有限公司 | 乐伐替尼甲磺酸盐的新晶型及其制备方法 |
-
2018
- 2018-04-20 WO PCT/CN2018/083861 patent/WO2018196687A1/zh active Application Filing
- 2018-04-20 CN CN201880024174.8A patent/CN110494423B/zh not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1890220A (zh) * | 2003-12-25 | 2007-01-03 | 卫材株式会社 | 4－(3－氯－4－(环丙基氨基羰基)氨基苯氧基)－7－甲氧基－6－喹啉羧酰胺的盐或其溶剂合物的结晶及其制备方法 |
| CN101233111A (zh) * | 2005-06-23 | 2008-07-30 | 卫材R&D管理有限公司 | 4-（3-氯-4-（环丙基氨基羰基）氨基苯氧基）-7-甲氧基-6-喹啉羧酸酰胺的无定形盐及其制备方法 |
| WO2016184436A1 (zh) * | 2015-05-21 | 2016-11-24 | 苏州晶云药物科技有限公司 | 乐伐替尼甲磺酸盐的新晶型及其制备方法 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113533544A (zh) * | 2020-04-16 | 2021-10-22 | 先声药业有限公司 | 一种甲磺酸仑伐替尼的有关物质检测方法 |
| CN114174264A (zh) * | 2020-04-24 | 2022-03-11 | 成都苑东生物制药股份有限公司 | 一种甲磺酸仑伐替尼晶型xi及其制备方法 |
| CN114174264B (zh) * | 2020-04-24 | 2024-02-27 | 成都苑东生物制药股份有限公司 | 一种甲磺酸仑伐替尼晶型xi及其制备方法 |
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| Publication number | Publication date |
|---|---|
| CN110494423B (zh) | 2022-04-26 |
| WO2018196687A1 (zh) | 2018-11-01 |
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