CN110475571B - 细胞免疫疗法前细胞毒性预调理的替代 - Google Patents

细胞免疫疗法前细胞毒性预调理的替代 Download PDF

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CN110475571B
CN110475571B CN201880021900.0A CN201880021900A CN110475571B CN 110475571 B CN110475571 B CN 110475571B CN 201880021900 A CN201880021900 A CN 201880021900A CN 110475571 B CN110475571 B CN 110475571B
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CN110475571A (zh
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T·A·迭舍尔
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AVM Biotechnology LLC
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    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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CN201880021900.0A 2017-04-01 2018-03-30 细胞免疫疗法前细胞毒性预调理的替代 Active CN110475571B (zh)

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Application Number Priority Date Filing Date Title
US201762480414P 2017-04-01 2017-04-01
US62/480,414 2017-04-01
US201862613697P 2018-01-04 2018-01-04
US62/613,697 2018-01-04
US201862624454P 2018-01-31 2018-01-31
US62/624,454 2018-01-31
PCT/US2018/025517 WO2018183927A1 (en) 2017-04-01 2018-03-30 Replacement of cytotoxic preconditioning before cellular immunotherapy

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CN110475571A CN110475571A (zh) 2019-11-19
CN110475571B true CN110475571B (zh) 2023-04-04

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US (2) US11219628B2 (https=)
EP (1) EP3490605B1 (https=)
JP (2) JP6748221B2 (https=)
KR (1) KR102509006B1 (https=)
CN (1) CN110475571B (https=)
AU (1) AU2018243753A1 (https=)
BR (1) BR112019020214A2 (https=)
CA (1) CA3054443A1 (https=)
ES (1) ES2954311T3 (https=)
IL (1) IL269209B2 (https=)
MX (1) MX2019011679A (https=)
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Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10426740B1 (en) 2010-08-18 2019-10-01 Avm Biotechnology, Llc Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues
WO2025019711A2 (en) * 2023-07-19 2025-01-23 Dermtech, Inc. Predicting therapeutic response based on biomarker signatures
EP3490605B1 (en) 2017-04-01 2023-06-07 AVM Biotechnology, LLC Replacement of cytotoxic preconditioning before cellular immunotherapy
EP4732889A2 (en) 2017-06-07 2026-04-29 Supira Medical, Inc. Intravascular fluid movement devices, systems, and methods of use
US11511103B2 (en) 2017-11-13 2022-11-29 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
JP7410034B2 (ja) 2018-02-01 2024-01-09 シファメド・ホールディングス・エルエルシー 血管内血液ポンプならびに使用および製造の方法
CA3097369A1 (en) 2018-04-17 2019-10-24 Celldex Therapeutics, Inc. Anti-cd27 and anti-pd-l1 antibodies and bispecific constructs
WO2020028537A1 (en) 2018-07-31 2020-02-06 Shifamed Holdings, Llc Intravascaular blood pumps and methods of use
EP3632446B3 (en) 2018-10-03 2024-01-24 AVM Biotechnology, LLC Immunoablative therapies
EP3488851A1 (en) * 2018-10-03 2019-05-29 AVM Biotechnology, LLC Immunoablative therapies
WO2020073047A1 (en) 2018-10-05 2020-04-09 Shifamed Holdings, Llc Intravascular blood pumps and methods of use
EA202191345A1 (ru) * 2018-11-14 2021-10-08 Авм Байотекнолоджи, Ллс Стабильный состав глюкокортикоидов
KR102946444B1 (ko) * 2018-11-16 2026-04-02 라파 쎄라퓨틱스 엘엘씨 제조된 t 세포로 암을 치료하는 방법
WO2020123444A1 (en) * 2018-12-11 2020-06-18 Celldex Therapeutics, Inc. Methods of using cd27 antibodies as conditioning treatment for adoptive cell therapy
AU2019397033B2 (en) 2018-12-12 2023-06-29 Kite Pharma, Inc. Chimeric antigen receptors and CAR-T cells and methods of use
WO2021011473A1 (en) 2019-07-12 2021-01-21 Shifamed Holdings, Llc Intravascular blood pumps and methods of manufacture and use
US11654275B2 (en) 2019-07-22 2023-05-23 Shifamed Holdings, Llc Intravascular blood pumps with struts and methods of use and manufacture
EP4010046A4 (en) 2019-08-07 2023-08-30 Calomeni, Michael Catheter blood pumps and collapsible pump housings
WO2021062260A1 (en) 2019-09-25 2021-04-01 Shifamed Holdings, Llc Catheter blood pumps and collapsible blood conduits
EP4034192B1 (en) 2019-09-25 2025-12-24 Supira Medical, Inc. Intravascular blood pump systems and methods of use and control thereof
EP4034221B1 (en) 2019-09-25 2024-11-13 Shifamed Holdings, LLC Catheter blood pumps and collapsible pump housings
IL292665B2 (en) * 2019-11-06 2026-02-01 Kite Pharma Inc Chimeric antigen receptor T cell therapy
EP4072650A4 (en) 2019-12-11 2024-01-10 Shifamed Holdings, LLC Descending aorta and vena cava blood pumps
US12599758B2 (en) 2019-12-19 2026-04-14 Shifamed Holdings, Llc Intravascular blood pumps, motors, and fluid control
CN113189340A (zh) * 2020-01-14 2021-07-30 中国医学科学院基础医学研究所 细胞焦亡通路在细胞治疗中的用途
EP4106775A4 (en) 2020-02-20 2024-03-06 Kite Pharma, Inc. CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY
CA3168378A1 (en) * 2020-02-28 2021-09-02 Avm Biotechnology, Llc Lypmphocyte population and methods for producing same
CN111443210B (zh) * 2020-04-10 2023-09-22 青海大学附属医院 泡型包虫病早期诊疗生物标志物及其应用
CN115989038A (zh) * 2020-04-10 2023-04-18 北卡罗莱纳州立大学 使用材料支架的增强的哺乳动物细胞病毒转导
US20230172950A1 (en) 2020-04-29 2023-06-08 Avm Biotechnology, Llc Glucocorticoid Receptor (GR) Modulators for Treating a SARS-COV-2 Virus
KR20230018422A (ko) 2020-06-01 2023-02-07 에이브이엠 바이오테크놀로지, 엘엘씨 Icam-조절제를 이용한 치료 방법
CN113797313A (zh) * 2020-06-11 2021-12-17 华北制药集团新药研究开发有限责任公司 卡非佐米作为冠状病毒广谱抑制剂的新用途
WO2022049572A1 (en) * 2020-09-01 2022-03-10 The National Institute for Biotechnology in the Negev Ltd. Immune system restoration by cell therapy
CN113322233A (zh) * 2021-04-19 2021-08-31 格源致善(上海)生物科技有限公司 一种改进的基于新生抗原反应性t细胞的制备方法及应用
WO2022226355A2 (en) * 2021-04-23 2022-10-27 Myeloid Therapeutics, Inc. Compositions and methods for conditioning patients for cell therapy
CN115947793B (zh) * 2021-08-13 2023-09-26 中国人民解放军总医院 靶向pd-l1的超高亲和力小蛋白及用途
EP4395784A1 (en) 2021-09-01 2024-07-10 AVM Biotechnology, LLC Lymphocyte population and methods for producing same
CN114031678A (zh) * 2021-12-08 2022-02-11 中国科学院新疆理化技术研究所 一种条斑钳蝎毒素多肽组分的制备方法及其应用
CN114767828A (zh) * 2022-04-25 2022-07-22 中国人民解放军海军军医大学 伊沙佐米在制备抗蜱传脑炎病毒、西尼罗病毒、黄热病毒和基孔肯雅热病毒感染药物中的应用
CN115785203B (zh) * 2022-06-10 2024-03-12 河北博海生物工程开发有限公司 肺癌特异性分子靶标10及其用途
CN116606352B (zh) * 2023-07-14 2023-09-29 诺赛联合(北京)生物医学科技有限公司 一种抗菌修复功能的组合物凝胶在妇科疾病中的应用
KR20250139235A (ko) 2025-07-15 2025-09-23 김종구 V-aemi 기반 인공지능 감정 음악 창작 시스템 및 그 방법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016191756A1 (en) * 2015-05-28 2016-12-01 Adrian Bot Methods of conditioning patients for t cell therapy
WO2018102606A1 (en) * 2016-11-30 2018-06-07 Intrexon Corporation Steroid administration and immunotherapy

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728388A (en) 1989-10-03 1998-03-17 Terman; David S. Method of cancer treatment
GB9323199D0 (en) 1993-11-10 1994-01-05 Falkenberg J H F Leukaemia treatment
EP1215497B1 (en) 1997-12-16 2009-01-07 University Of Zurich Diagnostics for transmissible spongiform encephalopathy
US6406699B1 (en) 1999-10-05 2002-06-18 Gary W. Wood Composition and method of cancer antigen immunotherapy
US20030099621A1 (en) * 2001-11-29 2003-05-29 Robert Chow Stem cell screening and transplantation therapy for HIV infection
IL146970A0 (en) 2001-12-06 2002-08-14 Yeda Res & Dev Migration of haematopoietic stem cells and progenitor cells to the liver
US7282222B2 (en) 2002-03-15 2007-10-16 The United States Of America As Represented By The Department Of Veterans Affairs Methods and compositions for directing cells to target organs
CA2752124A1 (en) 2002-05-17 2003-11-27 Celgene Corporation Methods and compositions using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for treatment and management of head and neck cancer
GB0310593D0 (en) 2003-05-08 2003-06-11 Leuven K U Res & Dev Peptidic prodrugs
US20040247574A1 (en) 2003-05-27 2004-12-09 Christopherson Kent W. Methods for enhancing stem cell engraftment during transplantation
WO2006071778A2 (en) 2004-12-23 2006-07-06 Ethicon Incorporated Treatment of parkinson's disease and related disorders using postpartum derived cells
PL1874821T3 (pl) * 2005-04-26 2013-09-30 Trion Pharma Gmbh Kombinacja przeciwciał i glikokortykoidów do leczenia raka
EP1907425B1 (en) 2005-07-22 2014-01-08 Y's Therapeutics Co., Ltd. Anti-cd26 antibodies and methods of use thereof
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
GB0700058D0 (en) 2007-01-03 2007-02-07 Scancell Aps Anti-tumor vaccine based on normal cells
AU2008210988B2 (en) 2007-02-01 2012-09-06 Allocure, Inc. Potentiation of stem cell homing and treatment of organ dysfunction or organ failure
MX2010012576A (es) * 2008-05-23 2011-04-05 Argos Therapeutics Inc Nuevos polipeptidos cd83 solubles, formulaciones y metodos de uso.
US20090299269A1 (en) 2008-05-29 2009-12-03 John Foley Vascular stimulation to aid intravascular cell replacement therapy
WO2009152186A1 (en) 2008-06-09 2009-12-17 American Stem Cell, Inc. Methods for enhancing cell therapy efficacy including treatment with cd26 peptidase inhibitors
ES2627043T3 (es) 2008-06-09 2017-07-26 Targazyme, Inc. Aumento de la eficacia de la terapia celular incluyendo tratamiento con alfa 1-3 fucoslitransferasa
US20100055107A1 (en) * 2008-07-31 2010-03-04 Defu Zeng Methods for preventing hematological malignancies and graft versus host disease by anti-cd3 preconditioning
US10426740B1 (en) * 2010-08-18 2019-10-01 Avm Biotechnology, Llc Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues
US20120045435A1 (en) * 2010-08-18 2012-02-23 Theresa Deisher Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
KR20140004174A (ko) 2011-01-18 2014-01-10 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 암 치료를 위한 조성물 및 방법
EP2532740A1 (en) 2011-06-11 2012-12-12 Michael Schmück Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy
CN103946952A (zh) 2011-09-16 2014-07-23 宾夕法尼亚大学董事会 用于治疗癌症的rna改造的t细胞
WO2014055657A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
AU2015244039B2 (en) * 2014-04-07 2021-10-21 Novartis Ag Treatment of cancer using anti-CD19 chimeric antigen receptor
BR112017013981A2 (pt) * 2015-01-26 2018-01-02 Cellectis receptores antigênicos quiméricos com uma única cadeia específicos anti-cll1 (sccars) para imunoterapia de câncer
EP3490605B1 (en) 2017-04-01 2023-06-07 AVM Biotechnology, LLC Replacement of cytotoxic preconditioning before cellular immunotherapy
EP3488851A1 (en) * 2018-10-03 2019-05-29 AVM Biotechnology, LLC Immunoablative therapies

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016191756A1 (en) * 2015-05-28 2016-12-01 Adrian Bot Methods of conditioning patients for t cell therapy
WO2018102606A1 (en) * 2016-11-30 2018-06-07 Intrexon Corporation Steroid administration and immunotherapy

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
A Phase I Study of Nonmyeloablative Chemotherapy and Adoptive Transfer of Autologous Tumor Antigen-Specific T Lymphocytes in Patients With Metastatic Melanoma;Mark E. Dudley等;《J Immunother.》;20021231;第25卷(第3期);全文 *
AVM BIOTECHNOLOGY.Making stem cells work better by advancing game-changing technologies for regenerative medicine, immune-oncology and fully human biologics manufacturing.《Making stem cells work better by advancing game-changing technologies for regenerative medicine, immune-oncology and fully human biologics manufacturing》.2016,第1-22页. *
Glucocorticoids Do Not Inhibit Antitumor Activity of Activated CD8+ T Cells;Christian S. Hinrichs等;《J Immunother.》;20051231;第28卷(第6期);全文 *

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