CN110382545A - 用抗pd-1抗体治疗癌症的方法 - Google Patents

用抗pd-1抗体治疗癌症的方法 Download PDF

Info

Publication number
CN110382545A
CN110382545A CN201880016132.XA CN201880016132A CN110382545A CN 110382545 A CN110382545 A CN 110382545A CN 201880016132 A CN201880016132 A CN 201880016132A CN 110382545 A CN110382545 A CN 110382545A
Authority
CN
China
Prior art keywords
cancer
dosage
flat
dose
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880016132.XA
Other languages
English (en)
Chinese (zh)
Inventor
D·詹金斯
H·拉肯
E·林
A·迪亚兹
鲁贤丹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tesaro Inc
Original Assignee
Tesaro Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tesaro Inc filed Critical Tesaro Inc
Publication of CN110382545A publication Critical patent/CN110382545A/zh
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880016132.XA 2017-01-09 2018-01-09 用抗pd-1抗体治疗癌症的方法 Pending CN110382545A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762444336P 2017-01-09 2017-01-09
US62/444,336 2017-01-09
US201762477423P 2017-03-27 2017-03-27
US62/477,423 2017-03-27
US201762491220P 2017-04-27 2017-04-27
US62/491,220 2017-04-27
US201762556386P 2017-09-09 2017-09-09
US62/556,386 2017-09-09
PCT/US2018/013029 WO2018129559A1 (en) 2017-01-09 2018-01-09 Methods of treating cancer with anti-pd-1 antibodies

Publications (1)

Publication Number Publication Date
CN110382545A true CN110382545A (zh) 2019-10-25

Family

ID=61188903

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880016132.XA Pending CN110382545A (zh) 2017-01-09 2018-01-09 用抗pd-1抗体治疗癌症的方法

Country Status (21)

Country Link
US (2) US11407830B2 (enExample)
EP (2) EP3565844B8 (enExample)
JP (2) JP7110206B6 (enExample)
KR (1) KR102606252B1 (enExample)
CN (1) CN110382545A (enExample)
AU (2) AU2018206481B2 (enExample)
BR (1) BR112019014187A2 (enExample)
CA (1) CA3049440A1 (enExample)
DK (1) DK3565844T5 (enExample)
ES (1) ES2945745T3 (enExample)
FI (1) FI3565844T3 (enExample)
HU (1) HUE061842T2 (enExample)
IL (1) IL267804B2 (enExample)
MA (1) MA47208A (enExample)
MX (1) MX2019008207A (enExample)
PL (1) PL3565844T3 (enExample)
PT (1) PT3565844T (enExample)
SG (2) SG10201913075RA (enExample)
TW (1) TWI767976B (enExample)
WO (1) WO2018129559A1 (enExample)
ZA (1) ZA201904316B (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021136523A1 (zh) * 2019-12-31 2021-07-08 甫康(上海)健康科技有限责任公司 一种用于治疗肿瘤的药物组合及其应用
CN115298218A (zh) * 2019-12-18 2022-11-04 特沙诺有限公司 生物药物组合物和相关方法
CN115607664A (zh) * 2021-07-15 2023-01-17 嘉和生物药业有限公司 抗pd-1抗体在治疗宫颈癌中的应用
CN115666542A (zh) * 2020-04-07 2023-01-31 梅塔诺伊治疗公司 用于治疗上皮性卵巢癌的乙醇胺调配物
WO2025040080A1 (en) * 2023-08-21 2025-02-27 Beigene Switzerland Gmbh Treatment of esophageal cancer with anti-lag3, anti-pd-1 and chemotherapy

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010011088A (es) 2008-04-09 2010-11-05 Genentech Inc Composiciones y metodos novedosos para el tratamiento de las enfermedades relacionadas con la inmunidad.
CA3037380A1 (en) 2016-10-11 2018-04-19 Agenus Inc. Anti-lag-3 antibodies and methods of use thereof
EP3666794A1 (en) * 2016-11-01 2020-06-17 AnaptysBio, Inc. Antibodies directed against programmed death- 1 (pd-1)
CN110382545A (zh) 2017-01-09 2019-10-25 泰萨罗公司 用抗pd-1抗体治疗癌症的方法
TWI879716B (zh) 2017-05-09 2025-04-11 美商提薩羅有限公司 治療癌症的組合療法
MA49144A (fr) 2017-05-18 2020-03-25 Tesaro Inc Polythérapies pour le traitement du cancer
BR112020006039A2 (pt) 2017-09-26 2020-10-06 Tesaro, Inc. formulações de niraparibe
CA3076515A1 (en) 2017-09-30 2019-04-04 Tesaro, Inc. Combination therapies for treating cancer
MA50618A (fr) 2017-10-06 2020-08-12 Tesaro Inc Polyrhérapies et leurs utilisations
KR20200119844A (ko) 2018-02-13 2020-10-20 머크 샤프 앤드 돔 코포레이션 항-pd-1 항체를 사용한 암의 치료 방법
TWI852940B (zh) * 2018-09-04 2024-08-21 美商泰沙羅公司 治療癌症之方法
EP3860988A1 (en) 2018-10-03 2021-08-11 Tesaro, Inc. Crystalline forms of niraparib freebase
ES2967517T3 (es) 2018-10-03 2024-04-30 Tesaro Inc Sales de niraparib
WO2020128908A2 (en) * 2018-12-20 2020-06-25 Medimmune, Llc Methods for selection and expansion of t cells expressing pd-1
US11613564B2 (en) * 2019-05-31 2023-03-28 ALX Oncology Inc. Methods of treating cancer
EP4096718A1 (en) 2020-01-28 2022-12-07 GlaxoSmithKline Intellectual Property Development Limited Combination treatments and uses and methods thereof
JP7593669B2 (ja) * 2020-02-18 2024-12-03 イノベイション バイオ カンパニー リミテッド コンパニオン診断用バイオマーカー組成物およびこれを含むコンパニオン診断用キット
LT4157876T (lt) 2020-05-26 2024-10-25 Boehringer Ingelheim International Gmbh Anti-pd-1 antikūnai
US20210395366A1 (en) * 2020-06-18 2021-12-23 Genentech, Inc. Treatment with anti-tigit antibodies and pd-1 axis binding antagonists
WO2022025482A1 (ko) * 2020-07-29 2022-02-03 재단법인 아산사회복지재단 스트렙토니그린 및 면역관문 억제제를 유효성분으로 포함하는 대장암 예방 및 치료용 조성물
WO2022090529A1 (en) * 2020-11-02 2022-05-05 Ares Trading S.A. Combination treatment of cancer
WO2023076668A1 (en) * 2021-10-29 2023-05-04 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compositions and methods for treatment of cancer
WO2023153763A1 (ko) * 2022-02-08 2023-08-17 고려대학교 산학협력단 C-met의 에피토프 및 hif1alpha의 에피토프를 포함하는 암 백신 및 이의 용도
AU2024252845A1 (en) 2023-04-06 2025-10-16 Glaxosmithkline Intellectual Property (No.4) Limited Methods for treating and monitoring cancer
GB202308807D0 (en) 2023-06-13 2023-07-26 Ionctura Sa Combinations

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101611054A (zh) * 2006-10-02 2009-12-23 Ac免疫有限公司 针对淀粉状蛋白β的人源化抗体
CN102782149A (zh) * 2009-11-04 2012-11-14 先灵公司 经工程改造的抗-tslp抗体
CN102892430A (zh) * 2010-03-17 2013-01-23 雅培研究有限公司 抗神经生长因子(ngf)抗体组合物
CN105339389A (zh) * 2013-05-02 2016-02-17 安奈普泰斯生物有限公司 针对程序性死亡-1(pd-1)的抗体
CN106255510A (zh) * 2014-03-05 2016-12-21 百时美施贵宝公司 使用抗pd‑1抗体与另一抗癌剂的组合治疗肾癌

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
EP0557459B1 (en) 1990-11-13 1997-10-22 Immunex Corporation Bifunctional selectable fusion genes
WO1994028143A1 (en) 1993-05-21 1994-12-08 Targeted Genetics Corporation Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene
US5814618A (en) 1993-06-14 1998-09-29 Basf Aktiengesellschaft Methods for regulating gene expression
US5464758A (en) 1993-06-14 1995-11-07 Gossen; Manfred Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
EP1210428B1 (en) 1999-08-23 2015-03-18 Dana-Farber Cancer Institute, Inc. Pd-1, a receptor for b7-4, and uses therefor
JP2004501624A (ja) 2000-06-28 2004-01-22 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー Pd−l2分子:新規pd−1リガンドおよびその使用
FR2814642B1 (fr) 2000-10-03 2005-07-01 Ass Pour Le Dev De La Rech En Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee
KR20030066657A (ko) 2000-11-15 2003-08-09 오노 야꾸힝 고교 가부시키가이샤 Pd-1 결손 마우스 및 그 용도
AR036993A1 (es) 2001-04-02 2004-10-20 Wyeth Corp Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas
EP2388590A1 (en) 2001-04-02 2011-11-23 Dana Farber Cancer Institute PD-1, a receptor for B7-4, and uses thereof
US20040241745A1 (en) 2001-07-31 2004-12-02 Tasuku Honjo Substance specific to pd-1
CA2466279A1 (en) 2001-11-13 2003-05-22 Dana-Farber Cancer Institute, Inc. Agents that modulate immune cell activation and methods of use thereof
AU2003281200A1 (en) 2002-07-03 2004-01-23 Tasuku Honjo Immunopotentiating compositions
CN101899114A (zh) 2002-12-23 2010-12-01 惠氏公司 抗pd-1抗体及其用途
EP1591527B1 (en) 2003-01-23 2015-08-26 Ono Pharmaceutical Co., Ltd. Substance specific to human pd-1
CN109485727A (zh) 2005-05-09 2019-03-19 小野药品工业株式会社 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法
EP3130350A1 (en) 2005-06-08 2017-02-15 Dana-Farber Cancer Institute, Inc. Methods and compositions for the treatment of persistent infections and cancer by inhibiting the programmed cell death 1 (pd-1)pathway
CA2611519A1 (en) 2005-06-17 2006-12-28 Tolerx, Inc. Ilt3 binding molecules and uses therefor
JP5093097B2 (ja) 2006-03-03 2012-12-05 小野薬品工業株式会社 細胞表面機能分子の細胞外領域多量体
NZ720288A (en) 2006-12-27 2020-02-28 Harvard College Compositions and methods for the treatment of infections and tumors
GEP20115337B (en) 2007-01-10 2011-11-25 St Di Ricerche Di Biologia Molecolare P Angeletti Spa Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
JP2010520748A (ja) 2007-02-20 2010-06-17 アナプティスバイオ インコーポレイティッド 体細胞超変異系
MY149129A (en) 2007-03-20 2013-07-15 Lilly Co Eli Anti-sclerostin antibodies
EP3176264B1 (en) 2007-05-30 2018-09-26 Postech Academy-Industry- Foundation Immunoglobulin fusion proteins
NZ600758A (en) 2007-06-18 2013-09-27 Merck Sharp & Dohme Antibodies to human programmed death receptor pd-1
US20090028857A1 (en) 2007-07-23 2009-01-29 Cell Genesys, Inc. Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof
US20120269806A1 (en) 2007-08-21 2012-10-25 The General Hospital Corporation Methods of inducing tolerance
US8563314B2 (en) 2007-09-27 2013-10-22 Sangamo Biosciences, Inc. Methods and compositions for modulating PD1
RU2542967C2 (ru) 2007-10-05 2015-02-27 Дженентек, Инк. Применение антитела против амилоида бета при глазных заболеваниях
NZ586675A (en) 2008-01-08 2012-04-27 Merck Sharp & Dohme Pharmaceutically acceptable salts of 2-{ 4-[(3s)-piperidin-3- yl]phenyl} -2h-indazole-7-carboxamide
EP2262837A4 (en) 2008-03-12 2011-04-06 Merck Sharp & Dohme PD-1 BINDING PROTEINS
EP2307050A4 (en) 2008-07-04 2012-07-25 Ono Pharmaceutical Co USE OF A EFFECTIVENESS MARKER TO OPTIMIZE THE THERAPEUTIC EFFECTIVENESS OF AN ANTI-HUMAN PD-1 ANTIBODY ON CANCERS
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
EP2927240A1 (en) 2008-08-25 2015-10-07 Amplimmune, Inc. Compositions of pd-1 antagonists and methods of use
EP2342228B1 (en) 2008-09-12 2017-09-06 Oxford University Innovation Limited Pd-1 specific antibodies and uses thereof
EP2342229A1 (en) 2008-09-12 2011-07-13 ISIS Innovation Limited Pd-1 specific antibodies and uses thereof
ES2592216T3 (es) 2008-09-26 2016-11-28 Dana-Farber Cancer Institute, Inc. Anticuerpos anti-PD-1, PD-L1 y PD-L2 humanos y sus usos
KR101050829B1 (ko) 2008-10-02 2011-07-20 서울대학교산학협력단 항 pd-1 항체 또는 항 pd-l1 항체를 포함하는 항암제
CN102282265B (zh) 2008-11-28 2020-07-24 埃默里大学 用于治疗传染病和肿瘤的方法
US8741295B2 (en) 2009-02-09 2014-06-03 Universite De La Mediterranee PD-1 antibodies and PD-L1 antibodies and uses thereof
EP2519544A1 (en) 2009-12-29 2012-11-07 Emergent Product Development Seattle, LLC Polypeptide heterodimers and uses thereof
WO2011100841A1 (en) 2010-02-16 2011-08-25 Valorisation-Recherche, Limited Partnership Pd-1 modulation and uses thereof for modulating hiv replication
TW201134488A (en) 2010-03-11 2011-10-16 Ucb Pharma Sa PD-1 antibodies
EP2545078A1 (en) 2010-03-11 2013-01-16 UCB Pharma, S.A. Pd-1 antibody
CA2793309A1 (en) 2010-03-17 2011-09-22 Anaptysbio, Inc. Method of producing transcripts using cryptic splice sites
US9163087B2 (en) 2010-06-18 2015-10-20 The Brigham And Women's Hospital, Inc. Bi-specific antibodies against TIM-3 and PD-1 for immunotherapy in chronic immune conditions
KR20130049196A (ko) 2010-08-05 2013-05-13 에프. 호프만-라 로슈 아게 항-mhc 항체 항-바이러스성 사이토카인 융합 단백질
WO2012021851A2 (en) 2010-08-12 2012-02-16 Beth Israel Deaconess Medical Center Methods and compositions for diagnosing and treating lupus
WO2012031122A2 (en) 2010-09-03 2012-03-08 Immport Therapeutics, Inc. Methods and compositions for the diagnosis and treatment of cancer and autoimmune disorders
US9029315B2 (en) 2010-11-11 2015-05-12 The University Of Hong Kong Soluble PD-1 variants, fusion constructs, and uses thereof
CA2830349C (en) 2011-03-17 2019-07-16 The University Of Birmingham Re-directed immunotherapy
US9220776B2 (en) 2011-03-31 2015-12-29 Merck Sharp & Dohme Corp. Stable formulations of antibodies to human programmed death receptor PD-1 and related treatments
CN102836441B (zh) 2011-06-24 2019-06-11 台北荣民总医院 于感染性与恶性疾病的治疗中提升免疫反应的方法
AR087405A1 (es) 2011-08-01 2014-03-19 Genentech Inc Metodos para tratar el cancer por el uso de antagonistas de union al eje pd-1 e inhibidores de mek
WO2013022091A1 (ja) 2011-08-11 2013-02-14 小野薬品工業株式会社 Pd-1アゴニストからなる自己免疫疾患治療剤
CA2845536A1 (en) 2011-08-15 2013-02-21 Amplimmune, Inc. Anti-b7-h4 antibodies and their uses
GB201203442D0 (en) 2012-02-28 2012-04-11 Univ Birmingham Immunotherapeutic molecules and uses
WO2013169693A1 (en) 2012-05-09 2013-11-14 Bristol-Myers Squibb Company Methods of treating cancer using an il-21 polypeptide and an anti-pd-1 antibody
US9856320B2 (en) 2012-05-15 2018-01-02 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
WO2013177102A2 (en) 2012-05-21 2013-11-28 Felder Mitchell S Treatment of cancer by manipulating the immune system
WO2013174997A1 (en) 2012-05-25 2013-11-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of refractory haematological malignancies
EP2855528B1 (en) 2012-05-31 2019-06-19 Genentech, Inc. Methods of treating cancer using pd-l1 axis binding antagonists and vegf antagonists
PE20160953A1 (es) 2013-12-12 2016-09-26 Shanghai hengrui pharmaceutical co ltd Anticuerpo pd-1, fragmento de union al antigeno de este y uso medico de este
TWI681969B (zh) 2014-01-23 2020-01-11 美商再生元醫藥公司 針對pd-1的人類抗體
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
ME03558B (me) 2014-03-14 2020-07-20 Novartis Ag Molekuli anti-lag-3 antiтela i njihove upotrebe
WO2015145360A1 (en) 2014-03-24 2015-10-01 Glennie Martin J Modified antibodies containing modified igg2 domains which elicit agonist or antagonistic properties and use thereof
DK3157956T3 (da) 2014-06-19 2020-04-27 Regeneron Pharma Ikke-humane dyr med et humaniseret gen med programmeret celledød 1
CA2957258C (en) 2014-08-05 2023-11-07 MabQuest SA Immunological reagents
WO2016029073A2 (en) * 2014-08-22 2016-02-25 Bristol-Myers Squibb Company Treatment of cancer using a combination of an anti-pd-1 antibody and an anti-cd137 antibody
EA201790737A1 (ru) 2014-10-03 2017-08-31 Новартис Аг Комбинированная терапия
MX382902B (es) 2014-10-31 2025-03-13 Oncomed Pharm Inc Inhibidor de la vía noth en combinación con un agente inmunoterapéutico para usarse en el tratamiento de cáncer.
MA41217A (fr) 2014-12-19 2017-10-24 Advaxis Inc Polythérapies ayant des souches de listeria recombinées
WO2016100882A1 (en) 2014-12-19 2016-06-23 Novartis Ag Combination therapies
CA2971734C (en) 2014-12-22 2025-11-18 Enumeral Biomedical Holdings Inc Anti-pd-1 antibodies
CA2972757A1 (en) 2014-12-31 2016-07-07 Arthur M. Krieg Combination tumor immunotherapy
WO2016112870A1 (en) 2015-01-16 2016-07-21 Tse-Wen Chang Molecular constructs with targeting and effector elements
MA41463A (fr) 2015-02-03 2017-12-12 Anaptysbio Inc Anticorps dirigés contre le gène d'activation 3 des lymphocytes (lag-3)
SG10201909173PA (en) 2015-04-01 2019-11-28 Anaptysbio Inc Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3)
NZ735820A (en) * 2015-04-17 2025-02-28 Bristol Myers Squibb Co Compositions comprising a combination of an anti-pd-1 antibody and another antibody
JP2018515474A (ja) 2015-04-28 2018-06-14 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company 抗pd−1抗体を使用するpd−l1陽性黒色腫の処置
DK3317301T3 (da) 2015-07-29 2021-06-28 Immutep Sas Kombinationsterapier omfattende antistofmolekyler mod lag-3
EP3478286B1 (en) 2016-06-29 2024-01-03 Tesaro, Inc. Methods of treating ovarian cancer
EP3666794A1 (en) * 2016-11-01 2020-06-17 AnaptysBio, Inc. Antibodies directed against programmed death- 1 (pd-1)
EP3689419A1 (en) 2016-11-01 2020-08-05 AnaptysBio, Inc. Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3)
TW201825512A (zh) * 2016-11-29 2018-07-16 美商提薩羅有限公司 針對計劃性死亡-1(pd-1)之抗體
CN110382545A (zh) 2017-01-09 2019-10-25 泰萨罗公司 用抗pd-1抗体治疗癌症的方法
CN110382000A (zh) 2017-01-09 2019-10-25 泰萨罗公司 用抗tim-3抗体治疗癌症的方法
CA3076515A1 (en) 2017-09-30 2019-04-04 Tesaro, Inc. Combination therapies for treating cancer
TWI852940B (zh) 2018-09-04 2024-08-21 美商泰沙羅公司 治療癌症之方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101611054A (zh) * 2006-10-02 2009-12-23 Ac免疫有限公司 针对淀粉状蛋白β的人源化抗体
CN102782149A (zh) * 2009-11-04 2012-11-14 先灵公司 经工程改造的抗-tslp抗体
CN102892430A (zh) * 2010-03-17 2013-01-23 雅培研究有限公司 抗神经生长因子(ngf)抗体组合物
CN105339389A (zh) * 2013-05-02 2016-02-17 安奈普泰斯生物有限公司 针对程序性死亡-1(pd-1)的抗体
CN106255510A (zh) * 2014-03-05 2016-12-21 百时美施贵宝公司 使用抗pd‑1抗体与另一抗癌剂的组合治疗肾癌

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CAROLINE ROBERT等: "Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial", 《THELANCET》 *
CAROLINE ROBERT等: "Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial", 《THELANCET》, vol. 384, no. 9948, 15 July 2014 (2014-07-15), pages 1 - 9 *
JOHN-PAUL SILVA等: "The S228P Mutation Prevents in Vivo and in Vitro IgG4 Fab-arm Exchange as Demonstrated using a Combination of Novel Quantitative Immunoassays and Physiological Matrix Preparation", JBC, vol. 290, no. 9, pages 5462 - 5469, XP055299482, DOI: 10.1074/jbc.M114.600973 *
RITUPARNA DAS等: "Combination Therapy with Anti-CTLA-4 and Anti-PD-1 Leads to Distinct Immunologic Changes In Vivo", 《THE JOURNAL OF IMMUNOLOGY》 *
RITUPARNA DAS等: "Combination Therapy with Anti-CTLA-4 and Anti-PD-1 Leads to Distinct Immunologic Changes In Vivo", 《THE JOURNAL OF IMMUNOLOGY》, vol. 194, no. 3, 18 February 2015 (2015-02-18), pages 950 - 959, XP055462350, DOI: 10.4049/jimmunol.1401686 *
SHRUTI AGRAWAL等: "Nivolumab dose selection: challenges,opportunities and lessons learned for cancer immunotherapy", 《JOURNAL FOR IMMUNOTHERAPY OF CANCER》 *
SHRUTI AGRAWAL等: "Nivolumab dose selection: challenges,opportunities and lessons learned for cancer immunotherapy", 《JOURNAL FOR IMMUNOTHERAPY OF CANCER》, vol. 3, no. 2, 4 November 2015 (2015-11-04), pages 141 - 143 *
王颖梅: "程序性死亡受体-1及其配体在子宫内膜癌中的研究进展", 现代妇产科进展, vol. 25, no. 11, pages 859 - 862 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115298218A (zh) * 2019-12-18 2022-11-04 特沙诺有限公司 生物药物组合物和相关方法
WO2021136523A1 (zh) * 2019-12-31 2021-07-08 甫康(上海)健康科技有限责任公司 一种用于治疗肿瘤的药物组合及其应用
CN113116881A (zh) * 2019-12-31 2021-07-16 甫康(上海)健康科技有限责任公司 一种用于治疗肿瘤的药物组合及其应用
CN113116881B (zh) * 2019-12-31 2025-03-07 甫康(上海)健康科技有限责任公司 一种用于治疗肿瘤的药物组合及其应用
CN115666542A (zh) * 2020-04-07 2023-01-31 梅塔诺伊治疗公司 用于治疗上皮性卵巢癌的乙醇胺调配物
CN115607664A (zh) * 2021-07-15 2023-01-17 嘉和生物药业有限公司 抗pd-1抗体在治疗宫颈癌中的应用
WO2025040080A1 (en) * 2023-08-21 2025-02-27 Beigene Switzerland Gmbh Treatment of esophageal cancer with anti-lag3, anti-pd-1 and chemotherapy

Also Published As

Publication number Publication date
DK3565844T5 (da) 2024-09-02
SG10201913075RA (en) 2020-02-27
TWI767976B (zh) 2022-06-21
IL267804A (en) 2019-09-26
US20200239574A1 (en) 2020-07-30
ES2945745T3 (es) 2023-07-06
PT3565844T (pt) 2023-05-02
JP2020504141A (ja) 2020-02-06
MA47208A (fr) 2019-11-13
BR112019014187A2 (pt) 2020-02-11
TW201831200A (zh) 2018-09-01
IL267804B1 (en) 2024-05-01
AU2025200639A1 (en) 2025-02-27
JP7110206B6 (ja) 2022-08-25
IL267804B2 (en) 2024-09-01
KR20190114996A (ko) 2019-10-10
FI3565844T3 (fi) 2023-05-09
WO2018129559A1 (en) 2018-07-12
EP3565844A1 (en) 2019-11-13
ZA201904316B (en) 2022-12-21
AU2018206481B2 (en) 2025-02-27
PL3565844T3 (pl) 2023-06-12
CA3049440A1 (en) 2018-07-12
AU2018206481A1 (en) 2019-07-25
EP3565844B8 (en) 2023-04-12
US20230111418A1 (en) 2023-04-13
JP7110206B2 (ja) 2022-08-01
MX2019008207A (es) 2019-12-11
KR102606252B1 (ko) 2023-11-23
EP3565844B1 (en) 2023-03-01
SG11201906192SA (en) 2019-08-27
US11407830B2 (en) 2022-08-09
DK3565844T3 (da) 2023-05-01
EP4219563A2 (en) 2023-08-02
HUE061842T2 (hu) 2023-08-28
JP2022082809A (ja) 2022-06-02
EP4219563A3 (en) 2023-10-04
US12415855B2 (en) 2025-09-16

Similar Documents

Publication Publication Date Title
JP7472190B2 (ja) 抗tim-3抗体を用いてがんを処置する方法
KR102606252B1 (ko) 항-pd-1 항체로 암을 치료하는 방법
TWI791519B (zh) 針對淋巴細胞活化基因-3(lag-3)之抗體藥劑及其用途
TWI865617B (zh) 抗原結合蛋白
EA043391B1 (ru) Способы лечения рака с помощью антител к pd-1
HK40016035A (en) Methods of treating cancer with anti-pd-1 antibodies
HK40016035B (en) Methods of treating cancer with anti-pd-1 antibodies
EA050059B1 (ru) Способы лечения рака с помощью антител к tim-3
NZ795702A (en) Methods of treating cancer with anti-pd-1 antibodies

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination