CN110267963B - Magl抑制剂 - Google Patents

Magl抑制剂 Download PDF

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Publication number
CN110267963B
CN110267963B CN201780083663.6A CN201780083663A CN110267963B CN 110267963 B CN110267963 B CN 110267963B CN 201780083663 A CN201780083663 A CN 201780083663A CN 110267963 B CN110267963 B CN 110267963B
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China
Prior art keywords
pharmaceutically acceptable
acceptable salt
formula
solvate
compounds
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Expired - Fee Related
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CN201780083663.6A
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English (en)
Chinese (zh)
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CN110267963A (zh
Inventor
谢丽尔·A·格莱斯
丹尼尔·J·布扎德
迈克尔·B·沙格哈飞
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H Lundbeck AS
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H Lundbeck AS
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Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201780083663.6A 2016-11-16 2017-11-15 Magl抑制剂 Expired - Fee Related CN110267963B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662423099P 2016-11-16 2016-11-16
US62/423,099 2016-11-16
PCT/US2017/061868 WO2018093947A1 (en) 2016-11-16 2017-11-15 Magl inhibitors

Publications (2)

Publication Number Publication Date
CN110267963A CN110267963A (zh) 2019-09-20
CN110267963B true CN110267963B (zh) 2022-04-01

Family

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Family Applications (1)

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CN201780083663.6A Expired - Fee Related CN110267963B (zh) 2016-11-16 2017-11-15 Magl抑制剂

Country Status (29)

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US (1) US10093635B2 (cg-RX-API-DMAC7.html)
EP (1) EP3541821A4 (cg-RX-API-DMAC7.html)
JP (1) JP7042547B2 (cg-RX-API-DMAC7.html)
KR (1) KR20190077544A (cg-RX-API-DMAC7.html)
CN (1) CN110267963B (cg-RX-API-DMAC7.html)
AR (1) AR110089A1 (cg-RX-API-DMAC7.html)
AU (1) AU2017361251B2 (cg-RX-API-DMAC7.html)
BR (1) BR112019009994A2 (cg-RX-API-DMAC7.html)
CA (1) CA3043615A1 (cg-RX-API-DMAC7.html)
CL (1) CL2019001339A1 (cg-RX-API-DMAC7.html)
CO (1) CO2019005059A2 (cg-RX-API-DMAC7.html)
CR (1) CR20190241A (cg-RX-API-DMAC7.html)
DO (1) DOP2019000122A (cg-RX-API-DMAC7.html)
EA (1) EA038090B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP19035077A (cg-RX-API-DMAC7.html)
GE (2) GEAP202215088A (cg-RX-API-DMAC7.html)
IL (1) IL266523B (cg-RX-API-DMAC7.html)
JO (1) JOP20190106A1 (cg-RX-API-DMAC7.html)
MA (1) MA46857A (cg-RX-API-DMAC7.html)
MX (1) MX391117B (cg-RX-API-DMAC7.html)
NI (1) NI201900051A (cg-RX-API-DMAC7.html)
PE (1) PE20191144A1 (cg-RX-API-DMAC7.html)
PH (1) PH12019501097A1 (cg-RX-API-DMAC7.html)
RU (1) RU2754536C1 (cg-RX-API-DMAC7.html)
TN (1) TN2019000153A1 (cg-RX-API-DMAC7.html)
TW (1) TWI756299B (cg-RX-API-DMAC7.html)
UA (1) UA124542C2 (cg-RX-API-DMAC7.html)
WO (1) WO2018093947A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201903100B (cg-RX-API-DMAC7.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9487495B2 (en) 2012-01-06 2016-11-08 The Scripts Research Institute Carbamate compounds and of making and using same
SG10202012002TA (en) 2015-05-11 2021-01-28 Lundbeck La Jolla Research Center Inc Methods of treating inflammation or neuropathic pain
JP7042804B2 (ja) 2016-09-19 2022-03-28 ルンドベック ラ ホーヤ リサーチ センター，インク． ピペラジンカルバメート、及びその製造と使用の方法
JOP20190107A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
KR20190085046A (ko) 2016-11-16 2019-07-17 어바이드 테라퓨틱스, 인크. 약학 제제
DK3541807T3 (da) 2016-11-16 2021-12-06 H Lundbeck As Krystallinsk form af en magl-inhibitor
EA201992409A1 (ru) 2017-05-23 2020-03-23 Лундбекк Ла-Хойя Рисерч Сентер, Инк. Ингибиторы magl на основе пиразола
JP7257387B2 (ja) 2017-08-29 2023-04-13 ハー・ルンドベック・アクチエゼルスカベット スピロ環化合物並びにその作製及び使用方法
KR20210010475A (ko) * 2018-05-15 2021-01-27 룬드벡 라 졸라 리서치 센터 인코포레이티드 Magl 저해제
MA54827A (fr) * 2019-01-25 2022-05-04 H Lundbeck As Méthodes de traitement d'une maladie à l'aide d'inhibiteurs de magl
KR20220101095A (ko) * 2019-11-15 2022-07-19 하. 룬드벡 아크티에셀스카브 Magl 억제제의 결정형
IT202000007150A1 (it) * 2020-04-03 2021-10-03 Univ Pisa Inibitori di monoacilglicerolo lipasi (magl)
IL297470A (en) 2020-04-21 2022-12-01 H Lundbeck As Synthesis of a monoacylglycerol lipase inhibitor
CA3242372A1 (en) 2021-12-29 2023-07-06 Psy Therapeutics, Inc. Inhibiting monoacylglycerol lipase (magl)
KR20250005229A (ko) 2022-05-04 2025-01-09 하. 룬드벡 아크티에셀스카브 모노아실글리세롤 리파제 억제제로서 1,1,1,3,3,3-헥사플루오로프로판-2-일 (s)-1-(피리다진-3-일카르바모일)-6 아자스피로[2.5]옥탄-6-카르복실레이트의 결정질 형태

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Also Published As

Publication number Publication date
CA3043615A1 (en) 2018-05-24
DOP2019000122A (es) 2019-09-30
MA46857A (fr) 2019-09-25
IL266523B (en) 2022-09-01
KR20190077544A (ko) 2019-07-03
US10093635B2 (en) 2018-10-09
PE20191144A1 (es) 2019-09-02
AU2017361251A1 (en) 2019-05-30
EP3541821A1 (en) 2019-09-25
CO2019005059A2 (es) 2019-05-31
UA124542C2 (uk) 2021-10-05
EA201991073A1 (ru) 2019-12-30
TW201823216A (zh) 2018-07-01
JP2020504707A (ja) 2020-02-13
RU2019116512A (ru) 2020-12-17
ZA201903100B (en) 2020-11-25
US20180134674A1 (en) 2018-05-17
NI201900051A (es) 2019-10-30
ECSP19035077A (es) 2019-05-31
CR20190241A (es) 2019-09-02
CN110267963A (zh) 2019-09-20
BR112019009994A2 (pt) 2019-08-27
EA038090B1 (ru) 2021-07-05
JOP20190106A1 (ar) 2019-05-09
IL266523A (en) 2019-07-31
AR110089A1 (es) 2019-02-20
WO2018093947A1 (en) 2018-05-24
CL2019001339A1 (es) 2019-10-04
TWI756299B (zh) 2022-03-01
MX391117B (es) 2025-03-21
MX2019005776A (es) 2019-12-05
PH12019501097A1 (en) 2019-08-19
GEP20237470B (en) 2023-02-10
GEAP202215088A (en) 2022-08-25
NZ753264A (en) 2020-12-18
RU2754536C1 (ru) 2021-09-03
JP7042547B2 (ja) 2022-03-28
EP3541821A4 (en) 2020-04-22
TN2019000153A1 (en) 2020-10-05
AU2017361251B2 (en) 2021-08-19

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