KR20190077544A - Magl 억제제 - Google Patents

Magl 억제제 Download PDF

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Publication number
KR20190077544A
KR20190077544A KR1020197016924A KR20197016924A KR20190077544A KR 20190077544 A KR20190077544 A KR 20190077544A KR 1020197016924 A KR1020197016924 A KR 1020197016924A KR 20197016924 A KR20197016924 A KR 20197016924A KR 20190077544 A KR20190077544 A KR 20190077544A
Authority
KR
South Korea
Prior art keywords
pharmaceutically acceptable
solvate
acceptable salt
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
KR1020197016924A
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English (en)
Korean (ko)
Inventor
셰릴 에이 그라이스
다니엘 제이. 버자드
마이클 비. 상하피
Original Assignee
어바이드 테라퓨틱스, 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 어바이드 테라퓨틱스, 인크. filed Critical 어바이드 테라퓨틱스, 인크.
Publication of KR20190077544A publication Critical patent/KR20190077544A/ko
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020197016924A 2016-11-16 2017-11-15 Magl 억제제 Abandoned KR20190077544A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662423099P 2016-11-16 2016-11-16
US62/423,099 2016-11-16
PCT/US2017/061868 WO2018093947A1 (en) 2016-11-16 2017-11-15 Magl inhibitors

Publications (1)

Publication Number Publication Date
KR20190077544A true KR20190077544A (ko) 2019-07-03

Family

ID=62106678

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197016924A Abandoned KR20190077544A (ko) 2016-11-16 2017-11-15 Magl 억제제

Country Status (29)

Country Link
US (1) US10093635B2 (cg-RX-API-DMAC7.html)
EP (1) EP3541821A4 (cg-RX-API-DMAC7.html)
JP (1) JP7042547B2 (cg-RX-API-DMAC7.html)
KR (1) KR20190077544A (cg-RX-API-DMAC7.html)
CN (1) CN110267963B (cg-RX-API-DMAC7.html)
AR (1) AR110089A1 (cg-RX-API-DMAC7.html)
AU (1) AU2017361251B2 (cg-RX-API-DMAC7.html)
BR (1) BR112019009994A2 (cg-RX-API-DMAC7.html)
CA (1) CA3043615A1 (cg-RX-API-DMAC7.html)
CL (1) CL2019001339A1 (cg-RX-API-DMAC7.html)
CO (1) CO2019005059A2 (cg-RX-API-DMAC7.html)
CR (1) CR20190241A (cg-RX-API-DMAC7.html)
DO (1) DOP2019000122A (cg-RX-API-DMAC7.html)
EA (1) EA038090B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP19035077A (cg-RX-API-DMAC7.html)
GE (2) GEAP202215088A (cg-RX-API-DMAC7.html)
IL (1) IL266523B (cg-RX-API-DMAC7.html)
JO (1) JOP20190106A1 (cg-RX-API-DMAC7.html)
MA (1) MA46857A (cg-RX-API-DMAC7.html)
MX (1) MX391117B (cg-RX-API-DMAC7.html)
NI (1) NI201900051A (cg-RX-API-DMAC7.html)
PE (1) PE20191144A1 (cg-RX-API-DMAC7.html)
PH (1) PH12019501097A1 (cg-RX-API-DMAC7.html)
RU (1) RU2754536C1 (cg-RX-API-DMAC7.html)
TN (1) TN2019000153A1 (cg-RX-API-DMAC7.html)
TW (1) TWI756299B (cg-RX-API-DMAC7.html)
UA (1) UA124542C2 (cg-RX-API-DMAC7.html)
WO (1) WO2018093947A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201903100B (cg-RX-API-DMAC7.html)

Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
US9487495B2 (en) 2012-01-06 2016-11-08 The Scripts Research Institute Carbamate compounds and of making and using same
SG10202012002TA (en) 2015-05-11 2021-01-28 Lundbeck La Jolla Research Center Inc Methods of treating inflammation or neuropathic pain
JP7042804B2 (ja) 2016-09-19 2022-03-28 ルンドベック ラ ホーヤ リサーチ センター，インク． ピペラジンカルバメート、及びその製造と使用の方法
JOP20190107A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
KR20190085046A (ko) 2016-11-16 2019-07-17 어바이드 테라퓨틱스, 인크. 약학 제제
DK3541807T3 (da) 2016-11-16 2021-12-06 H Lundbeck As Krystallinsk form af en magl-inhibitor
EA201992409A1 (ru) 2017-05-23 2020-03-23 Лундбекк Ла-Хойя Рисерч Сентер, Инк. Ингибиторы magl на основе пиразола
JP7257387B2 (ja) 2017-08-29 2023-04-13 ハー・ルンドベック・アクチエゼルスカベット スピロ環化合物並びにその作製及び使用方法
KR20210010475A (ko) * 2018-05-15 2021-01-27 룬드벡 라 졸라 리서치 센터 인코포레이티드 Magl 저해제
MA54827A (fr) * 2019-01-25 2022-05-04 H Lundbeck As Méthodes de traitement d'une maladie à l'aide d'inhibiteurs de magl
KR20220101095A (ko) * 2019-11-15 2022-07-19 하. 룬드벡 아크티에셀스카브 Magl 억제제의 결정형
IT202000007150A1 (it) * 2020-04-03 2021-10-03 Univ Pisa Inibitori di monoacilglicerolo lipasi (magl)
IL297470A (en) 2020-04-21 2022-12-01 H Lundbeck As Synthesis of a monoacylglycerol lipase inhibitor
CA3242372A1 (en) 2021-12-29 2023-07-06 Psy Therapeutics, Inc. Inhibiting monoacylglycerol lipase (magl)
KR20250005229A (ko) 2022-05-04 2025-01-09 하. 룬드벡 아크티에셀스카브 모노아실글리세롤 리파제 억제제로서 1,1,1,3,3,3-헥사플루오로프로판-2-일 (s)-1-(피리다진-3-일카르바모일)-6 아자스피로[2.5]옥탄-6-카르복실레이트의 결정질 형태

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Also Published As

Publication number Publication date
CA3043615A1 (en) 2018-05-24
DOP2019000122A (es) 2019-09-30
CN110267963B (zh) 2022-04-01
MA46857A (fr) 2019-09-25
IL266523B (en) 2022-09-01
US10093635B2 (en) 2018-10-09
PE20191144A1 (es) 2019-09-02
AU2017361251A1 (en) 2019-05-30
EP3541821A1 (en) 2019-09-25
CO2019005059A2 (es) 2019-05-31
UA124542C2 (uk) 2021-10-05
EA201991073A1 (ru) 2019-12-30
TW201823216A (zh) 2018-07-01
JP2020504707A (ja) 2020-02-13
RU2019116512A (ru) 2020-12-17
ZA201903100B (en) 2020-11-25
US20180134674A1 (en) 2018-05-17
NI201900051A (es) 2019-10-30
ECSP19035077A (es) 2019-05-31
CR20190241A (es) 2019-09-02
CN110267963A (zh) 2019-09-20
BR112019009994A2 (pt) 2019-08-27
EA038090B1 (ru) 2021-07-05
JOP20190106A1 (ar) 2019-05-09
IL266523A (en) 2019-07-31
AR110089A1 (es) 2019-02-20
WO2018093947A1 (en) 2018-05-24
CL2019001339A1 (es) 2019-10-04
TWI756299B (zh) 2022-03-01
MX391117B (es) 2025-03-21
MX2019005776A (es) 2019-12-05
PH12019501097A1 (en) 2019-08-19
GEP20237470B (en) 2023-02-10
GEAP202215088A (en) 2022-08-25
NZ753264A (en) 2020-12-18
RU2754536C1 (ru) 2021-09-03
JP7042547B2 (ja) 2022-03-28
EP3541821A4 (en) 2020-04-22
TN2019000153A1 (en) 2020-10-05
AU2017361251B2 (en) 2021-08-19

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