CN110267659A - 用于治疗cdk4/6介导的癌症的组合物和方法 - Google Patents

用于治疗cdk4/6介导的癌症的组合物和方法 Download PDF

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Publication number
CN110267659A
CN110267659A CN201780085879.6A CN201780085879A CN110267659A CN 110267659 A CN110267659 A CN 110267659A CN 201780085879 A CN201780085879 A CN 201780085879A CN 110267659 A CN110267659 A CN 110267659A
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alkyl
cdk4
base
cancer
degradation
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金剑
杨晓宝
刘静
熊燕
P·普列卡科斯
Z·卡罗利亚
吴雪薇
T·艾哈迈德
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Xi Naishanyikan Medical College
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Xi Naishanyikan Medical College
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • A—HUMAN NECESSITIES
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201780085879.6A 2016-12-08 2017-12-07 用于治疗cdk4/6介导的癌症的组合物和方法 Pending CN110267659A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662431806P 2016-12-08 2016-12-08
US62/431,806 2016-12-08
PCT/US2017/065027 WO2018106870A1 (en) 2016-12-08 2017-12-07 Compositions and methods for treating cdk4/6-mediated cancer

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US (2) US11541051B2 (https=)
EP (1) EP3551185A4 (https=)
JP (1) JP2020514252A (https=)
CN (1) CN110267659A (https=)
AU (1) AU2017370694A1 (https=)
CA (1) CA3045037A1 (https=)
WO (1) WO2018106870A1 (https=)

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CN114349738A (zh) * 2020-10-14 2022-04-15 清华大学 一类靶向降解cdk2的小分子缀合物及其应用
CN114957249A (zh) * 2022-05-20 2022-08-30 东南大学 一种不可逆共价结合cdk抑制剂及其制备方法和应用
CN115650968A (zh) * 2022-12-27 2023-01-31 英矽智能科技(上海)有限公司 作为cdk选择性抑制剂的新型哒嗪酮化合物
CN116239566A (zh) * 2021-12-08 2023-06-09 标新生物医药科技(上海)有限公司 E3泛素连接酶配体化合物、基于该配体化合物开发的蛋白降解剂及它们的应用
WO2026067249A1 (en) * 2024-09-29 2026-04-02 K2 Medicines (Nanjing) Co., Ltd. Cdk4 or cdk4/6 dual degrader and use thereof

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