AU2017370694A1 - Compositions and methods for treating CDK4/6-mediated cancer - Google Patents
Compositions and methods for treating CDK4/6-mediated cancer Download PDFInfo
- Publication number
- AU2017370694A1 AU2017370694A1 AU2017370694A AU2017370694A AU2017370694A1 AU 2017370694 A1 AU2017370694 A1 AU 2017370694A1 AU 2017370694 A AU2017370694 A AU 2017370694A AU 2017370694 A AU2017370694 A AU 2017370694A AU 2017370694 A1 AU2017370694 A1 AU 2017370694A1
- Authority
- AU
- Australia
- Prior art keywords
- cdk4
- cancer
- alkyl
- amino
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 0 CI(C1)C1C1*CCC1 Chemical compound CI(C1)C1C1*CCC1 0.000 description 4
- AHJRHEGDXFFMBM-UHFFFAOYSA-N CC(C(C(N1C2CCCC2)=O)=C(C)c2c1nc(Nc(nc1)ccc1N1CCNCC1)nc2)=O Chemical compound CC(C(C(N1C2CCCC2)=O)=C(C)c2c1nc(Nc(nc1)ccc1N1CCNCC1)nc2)=O AHJRHEGDXFFMBM-UHFFFAOYSA-N 0.000 description 2
- TUGNGRYJMWXYFO-WJOKGBTCSA-N CC(C(C(N1C2CCCC2)=O)=C(C)c2c1nc(Nc(cc1)ncc1N(CC1)CCN1C(CCc1c(CN([C@H](CCC(N3)=O)C3=O)C3=O)c3ccc1)=O)nc2)=O Chemical compound CC(C(C(N1C2CCCC2)=O)=C(C)c2c1nc(Nc(cc1)ncc1N(CC1)CCN1C(CCc1c(CN([C@H](CCC(N3)=O)C3=O)C3=O)c3ccc1)=O)nc2)=O TUGNGRYJMWXYFO-WJOKGBTCSA-N 0.000 description 1
- WAMBPOGCMYKCMP-UHFFFAOYSA-N CC(C(C(N1C2CCCC2)=O)=C(C)c2c1nc(Nc(cc1)ncc1N1CCN(CC(Nc(cccc3C(N4C(CCC(N5)=C)C5=O)=O)c3C4=O)=O)CC1)nc2)=O Chemical compound CC(C(C(N1C2CCCC2)=O)=C(C)c2c1nc(Nc(cc1)ncc1N1CCN(CC(Nc(cccc3C(N4C(CCC(N5)=C)C5=O)=O)c3C4=O)=O)CC1)nc2)=O WAMBPOGCMYKCMP-UHFFFAOYSA-N 0.000 description 1
- BULPVMQBJAMSRN-MSOLQXFVSA-N CC(C)(C)CC(N(C[C@@H](C1)O)[C@@H]1C(NCc(cc1)ccc1-c1c(C)nc[s]1)=O)=O Chemical compound CC(C)(C)CC(N(C[C@@H](C1)O)[C@@H]1C(NCc(cc1)ccc1-c1c(C)nc[s]1)=O)=O BULPVMQBJAMSRN-MSOLQXFVSA-N 0.000 description 1
- FVXIKGYWGLNGQZ-BEQDEZRVSA-N CC(C)(C)[C@@H](CS(N(CC1)CCN1C(CCCCCCC(N(CC1)CCN1c1ccc(Nc(nc2)nc(N3C4CCCC4)c2C(C)=C(C(C)=O)C3=O)nc1)=O)=O)(=O)=O)N([C@@H]([C@H](C[C@]1(C)CC(O)=O)c2cc(C)ccc2)c(cc2)ccc2Cl)C1=O Chemical compound CC(C)(C)[C@@H](CS(N(CC1)CCN1C(CCCCCCC(N(CC1)CCN1c1ccc(Nc(nc2)nc(N3C4CCCC4)c2C(C)=C(C(C)=O)C3=O)nc1)=O)=O)(=O)=O)N([C@@H]([C@H](C[C@]1(C)CC(O)=O)c2cc(C)ccc2)c(cc2)ccc2Cl)C1=O FVXIKGYWGLNGQZ-BEQDEZRVSA-N 0.000 description 1
- YKLKCIMJVHKPBP-KIYNQFGBSA-N CC(C)(CC(N(CC(C1)O)[C@@H]1C(N)=O)=O)C/[O]=C(/COCC(C)=O)\N Chemical compound CC(C)(CC(N(CC(C1)O)[C@@H]1C(N)=O)=O)C/[O]=C(/COCC(C)=O)\N YKLKCIMJVHKPBP-KIYNQFGBSA-N 0.000 description 1
- FJNLFMNUVZBURC-UHFFFAOYSA-N CC(C)C(C(N(CCC1)C1C(NCc(cc1)c(C)cc1-c1c(C)nc[s]1)=O)=O)N(Cc1c2cccc1)C2=O Chemical compound CC(C)C(C(N(CCC1)C1C(NCc(cc1)c(C)cc1-c1c(C)nc[s]1)=O)=O)N(Cc1c2cccc1)C2=O FJNLFMNUVZBURC-UHFFFAOYSA-N 0.000 description 1
- BDUHCSBCVGXTJM-WUFINQPMSA-N CC(C)Oc(cc(cc1)OC)c1C(N([C@@H]1c(cc2)ccc2Cl)C(N(CCN2)CC2=O)=O)=N[C@H]1c(cc1)ccc1Cl Chemical compound CC(C)Oc(cc(cc1)OC)c1C(N([C@@H]1c(cc2)ccc2Cl)C(N(CCN2)CC2=O)=O)=N[C@H]1c(cc1)ccc1Cl BDUHCSBCVGXTJM-WUFINQPMSA-N 0.000 description 1
- KANJWFUBVDCRIB-UHFFFAOYSA-N CC(C1=C(C)c2cnc(Nc(nc3)ccc3N(CC3)CCN3C(CCCNc(cccc3C(N4C(CCC(N5)=C)C5=O)=O)c3C4=O)=O)nc2N(C2CCCC2)C1=O)=O Chemical compound CC(C1=C(C)c2cnc(Nc(nc3)ccc3N(CC3)CCN3C(CCCNc(cccc3C(N4C(CCC(N5)=C)C5=O)=O)c3C4=O)=O)nc2N(C2CCCC2)C1=O)=O KANJWFUBVDCRIB-UHFFFAOYSA-N 0.000 description 1
- GREPRKDRPBLKRH-UHFFFAOYSA-N CC(CCCC(N(CC1)CCN1c1ccc(Nc(nc2)nc(N3C4CCCC4)c2C(C)=C(C(C)=O)C3=O)nc1)=O)=O Chemical compound CC(CCCC(N(CC1)CCN1c1ccc(Nc(nc2)nc(N3C4CCCC4)c2C(C)=C(C(C)=O)C3=O)nc1)=O)=O GREPRKDRPBLKRH-UHFFFAOYSA-N 0.000 description 1
- GVTRHVKNMMSAJV-HIDCPEKUSA-N CC(C[C@@H]1CC(C[C@@H](Cc2ccccc2)N)=O)NC1=O Chemical compound CC(C[C@@H]1CC(C[C@@H](Cc2ccccc2)N)=O)NC1=O GVTRHVKNMMSAJV-HIDCPEKUSA-N 0.000 description 1
- UBTNTAAHRZHBQJ-UHFFFAOYSA-N CC1NC(NC(C)(N2)N=Cc3c2[n](C2CCCC2)c(C(N(C)C)=O)c3)=CC=C1N(CC1)CCN1C(CNc(cccc1C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O Chemical compound CC1NC(NC(C)(N2)N=Cc3c2[n](C2CCCC2)c(C(N(C)C)=O)c3)=CC=C1N(CC1)CCN1C(CNc(cccc1C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O UBTNTAAHRZHBQJ-UHFFFAOYSA-N 0.000 description 1
- UZAJDQVPBKIFJO-XDQLBQEWSA-N CC1SC(c2ccc(CNC([C@H](C[C@H](C3)O)N3C(CC(C)(C)C/[O]=C(/CCCCC(O)=O)\N)=O)=O)cc2)=C(C)N1 Chemical compound CC1SC(c2ccc(CNC([C@H](C[C@H](C3)O)N3C(CC(C)(C)C/[O]=C(/CCCCC(O)=O)\N)=O)=O)cc2)=C(C)N1 UZAJDQVPBKIFJO-XDQLBQEWSA-N 0.000 description 1
- IRFRWLCOYSRMRO-OIDHKYIRSA-N CCOc1cc(C(C)(C)C)ccc1C(N([C@]1(C)c(cc2)ccc2Cl)C(N2CCN(C)CC2)=O)=N[C@@]1(C)c(cc1)ccc1Cl Chemical compound CCOc1cc(C(C)(C)C)ccc1C(N([C@]1(C)c(cc2)ccc2Cl)C(N2CCN(C)CC2)=O)=N[C@@]1(C)c(cc1)ccc1Cl IRFRWLCOYSRMRO-OIDHKYIRSA-N 0.000 description 1
- RLXGEFGRVFTYDW-ADLFWFRXSA-N C[C@@H](c(cc1)ccc1-c1c(C)nc[s]1)NC([C@H](CCC1)N1C([C@H](C(C)(C)C)N)=O)=O Chemical compound C[C@@H](c(cc1)ccc1-c1c(C)nc[s]1)NC([C@H](CCC1)N1C([C@H](C(C)(C)C)N)=O)=O RLXGEFGRVFTYDW-ADLFWFRXSA-N 0.000 description 1
- NZRWECQCBREPPG-UHFFFAOYSA-N NC(CCCCCCC(O)=O)=O Chemical compound NC(CCCCCCC(O)=O)=O NZRWECQCBREPPG-UHFFFAOYSA-N 0.000 description 1
- KDKGWGUUUVROTO-UHFFFAOYSA-N ON1CCNCC1 Chemical compound ON1CCNCC1 KDKGWGUUUVROTO-UHFFFAOYSA-N 0.000 description 1
- IFTRZFNPLYEHNU-UHFFFAOYSA-N [O-][N+](c(cc1)ccc1OC(Nc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O)=O Chemical compound [O-][N+](c(cc1)ccc1OC(Nc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O)=O IFTRZFNPLYEHNU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/02—Aminoacyltransferases (2.3.2)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662431806P | 2016-12-08 | 2016-12-08 | |
| US62/431,806 | 2016-12-08 | ||
| PCT/US2017/065027 WO2018106870A1 (en) | 2016-12-08 | 2017-12-07 | Compositions and methods for treating cdk4/6-mediated cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2017370694A1 true AU2017370694A1 (en) | 2019-07-25 |
Family
ID=62491322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017370694A Abandoned AU2017370694A1 (en) | 2016-12-08 | 2017-12-07 | Compositions and methods for treating CDK4/6-mediated cancer |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11541051B2 (https=) |
| EP (1) | EP3551185A4 (https=) |
| JP (1) | JP2020514252A (https=) |
| CN (1) | CN110267659A (https=) |
| AU (1) | AU2017370694A1 (https=) |
| CA (1) | CA3045037A1 (https=) |
| WO (1) | WO2018106870A1 (https=) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ME03557B (me) | 2013-03-15 | 2020-07-20 | G1 Therapeutics Inc | Privremena zaštiтa normalnih ćelija током hemoterapije |
| WO2018005863A1 (en) * | 2016-07-01 | 2018-01-04 | G1 Therapeutics, Inc. | Pyrimidine-based compounds for the treatment of cancer |
| RU2019102647A (ru) | 2016-07-01 | 2020-08-03 | Г1 Терапьютикс, Инк. | Антипролиферационные средства на основе пиримидина |
| KR20190084063A (ko) | 2016-10-28 | 2019-07-15 | 이칸 스쿨 오브 메디슨 엣 마운트 시나이 | Ｅｚｈ２-매개성 암 치료용 조성물 및 방법 |
| WO2018106870A1 (en) | 2016-12-08 | 2018-06-14 | Icahn School Of Medicine At Mount Sinai | Compositions and methods for treating cdk4/6-mediated cancer |
| US11173211B2 (en) | 2016-12-23 | 2021-11-16 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides |
| EP4467143B1 (en) | 2017-07-10 | 2026-03-11 | Celgene Corporation | Method for preparing 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-l-yl)-3-fluorobenzonitrile |
| CN109516989B (zh) * | 2017-09-17 | 2021-12-31 | 上海美志医药科技有限公司 | 一类抑制并降解cdk的化合物 |
| WO2019126731A1 (en) | 2017-12-22 | 2019-06-27 | Petra Pharma Corporation | Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
| JP2021515013A (ja) | 2018-03-06 | 2021-06-17 | アイカーン スクール オブ メディスン アット マウント シナイ | セリンスレオニンキナーゼ（ａｋｔ）分解／破壊化合物および使用方法 |
| US12539292B2 (en) | 2018-04-01 | 2026-02-03 | Arvinas Operations, Inc. | BRM targeting compounds and associated methods of use |
| FI3784663T3 (fi) | 2018-04-23 | 2023-10-06 | Celgene Corp | Substituoituja 4-aminoisoindoliini-1,3-dioniyhdisteitä ja niiden käyttö lymfooman hoitamiseksi |
| CN110615779B (zh) * | 2018-06-20 | 2023-03-24 | 上海科技大学 | 制备来那度胺衍生物的方法 |
| EP3810145A4 (en) * | 2018-06-21 | 2022-06-01 | Icahn School of Medicine at Mount Sinai | Wd40 repeat domain protein 5 (wdr5) degradation / disruption compounds and methods of use |
| CA3105121A1 (en) * | 2018-07-05 | 2020-01-09 | Icahn School Of Medicine At Mount Sinai | Protein tyrosine kinase 6 (ptk6) degradation / disruption compounds and methods of use |
| US11091522B2 (en) | 2018-07-23 | 2021-08-17 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| CN108948136A (zh) * | 2018-08-06 | 2018-12-07 | 浙江华海药业股份有限公司 | 一种赖诺普利杂质及其制备方法 |
| CN110835345A (zh) * | 2018-08-17 | 2020-02-25 | 中国科学院上海药物研究所 | 一类细胞周期依赖性激酶的降解剂、其制备方法、药物组合物及其用途 |
| JP7297053B2 (ja) | 2018-08-20 | 2023-06-23 | アルビナス・オペレーションズ・インコーポレイテッド | 神経変性疾患を治療するためのｅ３ユビキチンリガーゼ結合活性を有するキメラ（ｐｒｏｔａｃ）化合物を標的とし、アルファ－シヌクレインタンパク質を標的とするタンパク質分解 |
| CN112912143A (zh) * | 2018-10-08 | 2021-06-04 | 美国密歇根州立大学试剂中心 | 小分子mdm2蛋白降解剂 |
| MX2021004191A (es) | 2018-10-15 | 2021-05-27 | Nurix Therapeutics Inc | Compuestos bifuncionales para degradar la tirosina cinasa de bruton (btk) mediante la trayectoria de ubiquitina proteosoma. |
| US20220002291A1 (en) * | 2018-11-02 | 2022-01-06 | The Wistar Institute Of Anatomy And Biology | Proteolysis-targeting chimeras |
| US20220016102A1 (en) * | 2018-11-21 | 2022-01-20 | Shanghaitech University | Er protein regulators and use thereof |
| CN113660937A (zh) * | 2019-02-08 | 2021-11-16 | 佛罗里达大学研究基金公司 | 治疗剂和治疗方法 |
| US12582722B2 (en) | 2019-02-13 | 2026-03-24 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway |
| WO2020173440A1 (en) * | 2019-02-27 | 2020-09-03 | Cullgen (Shanghai), Inc. | Cyclic-amp response element binding protein (cbp) and/or adenoviral e1a binding protein of 300 kda (p300) degradation compounds and methods of use |
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