CN110236200A - 一种含活性叶酸和亚麻酸的综合营养包 - Google Patents
一种含活性叶酸和亚麻酸的综合营养包 Download PDFInfo
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- CN110236200A CN110236200A CN201910453203.9A CN201910453203A CN110236200A CN 110236200 A CN110236200 A CN 110236200A CN 201910453203 A CN201910453203 A CN 201910453203A CN 110236200 A CN110236200 A CN 110236200A
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- vitamin
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- linolenic
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- 239000011674 pyridoxal Substances 0.000 description 1
- 235000008151 pyridoxamine Nutrition 0.000 description 1
- 239000011699 pyridoxamine Substances 0.000 description 1
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- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
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- 239000011669 selenium Substances 0.000 description 1
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- 229930003799 tocopherol Natural products 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 125000002640 tocopherol group Chemical group 0.000 description 1
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
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Abstract
本发明公开了一种含活性叶酸和亚麻酸的综合营养包,由按照原料质量调配而成,原料包括以下原料粉末并对应相应质量:5‑甲基四氢叶酸:100ug‑200ug;综合天然果蔬粉:1g‑2g;亚麻籽油微囊粉:4g‑6g;牛磺酸:10mg‑30mg;卵磷脂:0.5g‑0.7g;甜菜碱:90mg‑110mg;木糖醇低聚果糖:天门冬氨酸钙:0.5g‑1.5g;烟酸:6mg‑8mg;泛酸:2mg‑4mg;维生素C:40mg‑60mg;维生素B12:0.5ug‑1.5ug;维生素B6:0.7mg‑0.9mg;维生素B2:0.5mg‑0.7mg;维生素B1:0.5mg‑0.7mg;维生素E:4.5mg‑5.1mg;维生素D3:2.0ug‑3.0ug;Β‑胡萝卜素:50ug‑70ug;维生素A:160ug‑180ug;DHA藻油微囊粉:50mg‑150mg;大豆分离蛋白:0.5g‑1.1g;甘氨酸锌:6mg‑8mg;甘氨酸亚铁:6mg‑8mg。本产品综合营养包通过改善胎盘功能,降低同型半胱氨酸,减少胎儿循环系统血栓改善胎儿肾血流量,从而改善羊水过少,疗效显著。
Description
技术领域
本发明涉及一种营养素领域,具体涉及一种含活性叶酸和亚麻酸的综合营养包。
背景技术
目前,市面上销售的针对孕晚期女性女性服用的营养品,在结合国家《表19孕晚期女性微量营养素参考摄入量》指标参考发现,现有市面上已销售该类产品出现如下缺陷:
第一、无法满足孕期营养需求,不利于孕期女性营养成分吸收;
第二、在促进胎儿生长发育和改善FGR方面存在缺陷;
第三、特别针对羊水过少的女性,改善其缺陷力度不够;
第四、无法实现降低同型半胱氨酸,进而改善胎盘功能的不足。
发明内容
本发明的目的是为克服上述现有技术的不足,提供一种含活性叶酸和亚麻酸的综合营养包。
为实现上述目的,本发明采用下述技术方案:
一种含活性叶酸和亚麻酸的综合营养包,由按照原料质量调配而成,所述原料包括以下原料粉末并对应相应质量:
5-甲基四氢叶酸:100ug-200ug;(注:5-甲基四氢叶酸粉末为还原型叶酸,并通过如第三方购买,如:中山郎特森生物科技有限公司购买等)
综合天然果蔬粉:1g-2g;
亚麻籽油微囊粉:4g-6g;(注:第三方购买等,如西安天象生物公司等)
牛磺酸:10mg-30mg;(注:第三方购买等,如河南赛森化工产品公司等)
卵磷脂:0.5g-0.7g;(注:第三方购买等,如河南赛森化工产品公司等)
甜菜碱:90mg-110mg;
木糖醇低聚果糖:0.1g-0.5g;天门冬氨酸钙:0.5g-1.5g;(注:第三方购买等,如陕西至地圣通食品公司等)
烟酸:6mg-8mg;(注:第三方购买等,如赛森化工产品有限公司等)
泛酸:2mg-4mg;(注:泛酸分子式C9H17NO5,为白色粉末或浅黄色粘稠状物)
维生素C:40mg-60mg;(注:维生素C又叫L-抗坏血酸,是一种水溶性维生素。)
维生素B12:0.5ug-1.5ug;(注:维生素B12(Vitamin B12)为B族维生素之一,是一类含钴的复杂有机化合物。分子结构是以钴离子为中心的咕啉环和5,6-二甲基苯并咪唑为碱基组成的核苷酸。)
维生素B6:0.7mg-0.9mg;(注:维生素B6(Vitamin B6)又称吡哆素,其包括吡哆醇、吡哆醛及吡哆胺,在体内以磷酸酯的形式存在,是一种水溶性维生素,遇光或碱易破坏,不耐高温。)
维生素B2:0.5mg-0.7mg;(注:维生素B2(化学式:C17H20N4O6,式量376.37)又叫核黄素,微溶于水,在中性或酸性溶液中加热是稳定的。)
维生素B1:0.5mg-0.7mg;
维生素E:4.5mg-5.1mg;(注:维生素E(Vitamin E)是一种脂溶性维生素,其水解产物为生育酚,是最主要的抗氧化剂之一。)
维生素D3:2.0ug-3.0ug;(注:胆钙化醇(英语:Cholecalciferol,又称为维生素D3或胆钙化固醇)是维生素D的一种,胆固醇脱氢后生成的7-脱氢胆固醇经紫外线照射即可形成胆钙化醇,因此也就是说胆钙化醇的维生素D原是7-脱氢胆固醇。)
Β-胡萝卜素:50ug-70ug;(注:β—胡萝卜素(C40H56)是类胡萝卜素之一,也是橘黄色脂溶性化合物,它是自然界中最普遍存在也是最稳定的天然色素。)
维生素A:160ug-180ug;(注:维生素A的化学名为视黄醇)
DHA藻油微囊粉:50mg-150mg;(注:第三方购买等,如西安华兴生物科技有限公司购买等)
大豆分离蛋白:0.5g-1.1g;(注:大豆大豆分离蛋白是以低温脱溶大豆粕为原料生产的一种全价蛋白类食品添加剂。)
甘氨酸锌:6mg-8mg;(注:甘氨酸锌是一种化学物质,分子式是C4H8N2O4Zn。第三方购买,如河南鼎祥化工产品有限公司。)
甘氨酸亚铁:6mg-8mg。(注:第三方购买,如河南鼎祥化工产品有限公司。)
作为最佳方案是:一种含活性叶酸和亚麻酸的综合营养包,由按照原料质量调配而成,所述原料包括以下原料粉末并对应相应质量:
5-甲基四氢叶酸:150ug;
综合天然果蔬粉:1.5g;
亚麻籽油微囊粉:5g;
牛磺酸:20mg;
卵磷脂:0.6g;
甜菜碱:100mg;
木糖醇低聚果糖:0.3g;
天门冬氨酸钙:1.0g;
烟酸:7mg;
泛酸:3mg;
维生素C:50mg;
维生素B12:1.0ug;
维生素B6:0.8mg;
维生素B2:0.6mg;
维生素B1:0.6mg;
维生素E:4.8mg;
维生素D3:2.5ug;
Β-胡萝卜素:60ug;
维生素A:170ug;
DHA藻油微囊粉:100mg;
大豆分离蛋白:0.8g;
甘氨酸锌:7mg;
甘氨酸亚铁:7mg。
进一步的,所述综合天然果蔬粉由红苋菜粉、绿苋菜粉、柑橘粉、菠菜粉和根甜菜粉中任意二种及以上全部混合均匀组成。
进一步地,所述原料经粉剂混合机混合20min-40min后停止,并获得混合均匀的混合粉体,接着将均匀混合粉体下漏至底部包装机内,并通过包装机依次均等份包装为10g/包的粉剂,30袋为一盒,最后打包装箱完毕。
进一步地,本综合营养包适用于孕中晚期妇女。
进一步地,所述综合营养包在正常孕期营养的妇女每天一次,每次一袋;孕期症状干预的妇女每天两次,每次1-2袋。
进一步地,所述综合营养包在服用时均可添加到温水、豆浆或牛奶中搅拌均匀饮用。
本发明的有益效果是,本综合营养包富含多种营养,采用微囊缓释吸收,α-亚麻酸+藻油DHA,双效搭配,吸收更好,采用综合天然果蔬粉活性营养素成分,高吸收利用率;其中活性营养无需体内代谢,直接被人体吸收利用;满足孕期营养需要,促进胎儿生长发育,改善FGR,改善孕妇羊水少和妊娠期高血压,降低同型半胱氨酸,改善孕妇胎盘功能,预防不良妊娠结局,改善妊娠期糖尿病。
附图说明
图1是本发明改善胎儿生长受限的临床观察的柱状图;
图2是本发明干预羊水过少效果分析的柱状图一;
图3是本发明干预羊水过少效果分析的柱状图二;
具体实施方式
下面结合附图和实施例对本发明进行进一步的阐述,应该说明的是,下述说明仅是为了解释本发明,并不对其内容进行限定。
实施例1
一种含活性叶酸和亚麻酸的综合营养包,由按照原料质量调配而成,原料包括以下原料粉末并对应相应质量:
5-甲基四氢叶酸:100ug;
综合天然果蔬粉:1g;
亚麻籽油微囊粉:4g;
牛磺酸:10mg;
卵磷脂:0.5g;
甜菜碱:90mg;
木糖醇低聚果糖:0.1g;
天门冬氨酸钙:0.5g;
烟酸:6mg;
泛酸:2mg;
维生素C:40mg;
维生素B12:0.5ug;
维生素B6:0.7mg;
维生素B2:0.5mg;
维生素B1:0.5mg;
维生素E:4.5mg;
维生素D3:2.0ug;
Β-胡萝卜素:50ug;
维生素A:160ug;
DHA藻油微囊粉:50mg;
大豆分离蛋白:0.5g;
甘氨酸锌:6mg;
甘氨酸亚铁:6mg。
综合天然果蔬粉由红苋菜粉、绿苋菜粉组合并各占总综合天然果蔬粉质量的50%比例使用。
实施例2
一种含活性叶酸和亚麻酸的综合营养包,由按照原料质量调配而成,原料包括以下原料粉末并对应相应质量:
6-甲基四氢叶酸:1200ug;
综合天然果蔬粉:2g;
亚麻籽油微囊粉:6g;
牛磺酸:30mg;
卵磷脂:0.7g;
甜菜碱:110mg;
木糖醇低聚果糖:0.5g;
天门冬氨酸钙:1.5g;
烟酸:8mg;
泛酸:4mg;
维生素C:60mg;
维生素B12:1.5ug;
维生素B6:0.9mg;
维生素B2:0.7mg;
维生素B1:0.7mg;
维生素E:5.1mg;
维生素D3:3.0ug;
Β-胡萝卜素:70ug;
维生素A:180ug;
DHA藻油微囊粉:150mg;
大豆分离蛋白:1.1g;
甘氨酸锌:8mg;
甘氨酸亚铁:8mg。
综合天然果蔬粉由红苋菜粉、绿苋菜粉、柑橘粉、菠菜粉组合并各占总综合天然果蔬粉质量的25%比例使用。
最佳实施例3
一种含活性叶酸和亚麻酸的综合营养包,由按照原料质量调配而成,原料包括以下原料粉末并对应相应质量:
5-甲基四氢叶酸:150ug;
综合天然果蔬粉:1.5g;
亚麻籽油微囊粉:5g;
牛磺酸:20mg;
卵磷脂:0.6g;
甜菜碱:100mg;
木糖醇低聚果糖:0.3g;
天门冬氨酸钙:1.0g;
烟酸:7mg;
泛酸:3mg;
维生素C:50mg;
维生素B12:1.0ug;
维生素B6:0.8mg;
维生素B2:0.6mg;
维生素B1:0.6mg;
维生素E:4.8mg;
维生素D3:2.5ug;
Β-胡萝卜素:60ug;
维生素A:170ug;
DHA藻油微囊粉:100mg;
大豆分离蛋白:0.8g;
甘氨酸锌:7mg;
甘氨酸亚铁:7mg。
综合天然果蔬粉由红苋菜粉、绿苋菜粉、、柑橘粉、菠菜粉和根甜菜粉组合并各占总综合天然果蔬粉质量的20%比例使用。
本产品的加工制备方法是:原料经粉剂混合机混合20min-40min后停止,并获得混合均匀的混合粉体,接着将均匀混合粉体下漏至底部包装机内,并通过包装机依次均等份包装为10g/包的粉剂,30袋为一盒,最后打包装箱完毕。
综合营养包在正常孕期营养的妇女每天一次,每次一袋;孕期症状干预的妇女每天两次,每次1-2袋;服用时均可添加到温水、豆浆或牛奶中搅拌均匀饮用。
实验例1:将实施例3中制备得到的一种含活性叶酸和亚麻酸的综合营养包,用于改善胎儿生长受限的临床观察试验,具体说明如下:
226例临床诊断FGR孕妇,随机分为对照组(113例)和本产品综合营养包组(113例),对照组采取丹参注射液干预,本产品综合营养包干预,比较两组治疗前后胎儿生长情况和脐血流变化情况。
如图1本发明改善胎儿生长受限的临床观察的柱状图所示:本产品综合营养包在孕妇宫高增长及腹围增长方面,优于对照组(P<0.05),胎儿双顶径(△BPD)及股骨长(△FL)改善方面显著优于对照组(P<0.01),因此获知本产品综合营养包可满足孕妇及胎儿营养需求,促进胎儿生长发育。
本产品综合营养包组脐动脉血流S/D值显著下降,优于对照组(P<0.01),因此获知本产品综合营养包对胎盘功能改善效果显著。
实验例2:将实施例3中制备得到的一种含活性叶酸和亚麻酸的综合营养包,用于改善羊水过少的临床观察试验,具体说明如下:
217例妊娠中晚期羊水过少妇女,随机分为对照组(108例)和本产品综合营养包(109例),对照组采取丹参注射液干预,本产品综合营养包干预,对两组患者干预效果进行分析和对比。
如图2和图3所示,可以分析得到两组对羊水过少干预效果均优于治疗前,其中本产品综合营养包组对羊水指数改善效果明显优于对照组(P<0.01);本产品综合营养包组对羊水改善总有效率为83.49%,显著优于对照组(63.89%);羊水过少患者中,使用本产品综合营养包干预患者,正常妊娠结局95人(87.16%),明显优于对照组72人(66.67%)。
综上所述,本产品综合营养包通过改善胎盘功能,降低同型半胱氨酸,减少胎儿循环系统血栓改善胎儿肾血流量,从而改善羊水过少,疗效显著。
上述虽然结合附图对本发明的具体实施方式进行了描述,但并非对本发明保护范围的限制,在本发明的技术方案的基础上,本领域技术人员不需要付出创造性劳动即可做出的各种修改或变形仍在本发明的保护范围以内。
Claims (7)
1.一种含活性叶酸和亚麻酸的综合营养包,由按照原料质量调配而成,其特征在于,所述原料包括以下原料粉末并对应相应质量:
5-甲基四氢叶酸:100ug-200ug;
综合天然果蔬粉:1g-2g;
亚麻籽油微囊粉:4g-6g;
牛磺酸:10mg-30mg;
卵磷脂:0.5g-0.7g;
甜菜碱:90mg-110mg;
木糖醇低聚果糖:0.1g-0.5g;
天门冬氨酸钙:0.5g-1.5g;
烟酸:6mg-8mg;
泛酸:2mg-4mg;
维生素C:40mg-60mg;
维生素B12:0.5ug-1.5ug;
维生素B6:0.7mg-0.9mg;
维生素B2:0.5mg-0.7mg;
维生素B1:0.5mg-0.7mg;
维生素E:4.5mg-5.1mg;
维生素D3:2.0ug-3.0ug;
Β-胡萝卜素:50ug-70ug;
维生素A:160ug-180ug;
DHA藻油微囊粉:50mg-150mg;
大豆分离蛋白:0.5g-1.1g;
甘氨酸锌:6mg-8mg;
甘氨酸亚铁:6mg-8mg。
2.根据权利要求1所述的一种含活性叶酸和亚麻酸的综合营养包,由按照原料质量调配而成,其特征是,所述原料包括以下原料粉末并对应相应质量:
5-甲基四氢叶酸:150ug;
综合天然果蔬粉:1.5g;
亚麻籽油微囊粉:5g;
牛磺酸:20mg;
卵磷脂:0.6g;
甜菜碱:100mg;
木糖醇低聚果糖:
天门冬氨酸钙:1.0g;
烟酸:7mg;
泛酸:3mg;
维生素C:50mg;
维生素B12:1.0ug;
维生素B6:0.8mg;
维生素B2:0.6mg;
维生素B1:0.6mg;
维生素E:4.8mg;
维生素D3:2.5ug;
Β-胡萝卜素:60ug;
维生素A:170ug;
DHA藻油微囊粉:100mg;
大豆分离蛋白:0.8g;
甘氨酸锌:7mg;
甘氨酸亚铁:7mg。
3.根据权利要求1或2所述的一种含活性叶酸和亚麻酸的综合营养包,其特征是,所述综合天然果蔬粉由红苋菜粉、绿苋菜粉、柑橘粉、菠菜粉和根甜菜粉中任意二种及以上全部混合均匀组成。
4.根据权利要求3所述的一种含活性叶酸和亚麻酸的综合营养包,其特征是,原料经粉剂混合机混合20min-40min后停止,并获得混合均匀的混合粉体,接着将均匀混合粉体下漏至底部包装机内,并通过包装机依次均等份包装为10g/包的粉剂,30袋为一盒,最后打包装箱完毕。
5.根据权利要求4所述的一种含活性叶酸和亚麻酸的综合营养包,其特征是,本综合营养包适用于孕中晚期妇女。
6.根据权利要求5所述的一种含活性叶酸和亚麻酸的综合营养包,其特征是,所述综合营养包在正常孕期营养的妇女每天一次,每次一袋;孕期症状干预的妇女每天两次,每次1-2袋。
7.根据权利要求6所述的一种含活性叶酸和亚麻酸的综合营养包,其特征是,所述综合营养包在服用时均可添加到温水、豆浆或牛奶中搅拌均匀饮用。
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