CN1102139C - 具有酪氨酸酶抑制活性的新1,3－二苯基丙烷衍生物及其制备方法 - Google Patents

具有酪氨酸酶抑制活性的新1,3－二苯基丙烷衍生物及其制备方法 Download PDF

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Publication number
CN1102139C
CN1102139C CN98800210A CN98800210A CN1102139C CN 1102139 C CN1102139 C CN 1102139C CN 98800210 A CN98800210 A CN 98800210A CN 98800210 A CN98800210 A CN 98800210A CN 1102139 C CN1102139 C CN 1102139C
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CN
China
Prior art keywords
compound
expression
definition
ethyl acetate
solvent
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Expired - Fee Related
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CN98800210A
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English (en)
Chinese (zh)
Other versions
CN1217709A (zh
Inventor
李映昊
金京爱
李贤浩
崔锺权
李相和
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LG H&H Co Ltd
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LG Chemical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/17—Saturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/172—Saturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN98800210A 1997-03-06 1998-03-02 具有酪氨酸酶抑制活性的新1,3－二苯基丙烷衍生物及其制备方法 Expired - Fee Related CN1102139C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1997/7452 1997-03-06
KR19970007452 1997-03-06

Publications (2)

Publication Number Publication Date
CN1217709A CN1217709A (zh) 1999-05-26
CN1102139C true CN1102139C (zh) 2003-02-26

Family

ID=19498891

Family Applications (1)

Application Number Title Priority Date Filing Date
CN98800210A Expired - Fee Related CN1102139C (zh) 1997-03-06 1998-03-02 具有酪氨酸酶抑制活性的新1,3－二苯基丙烷衍生物及其制备方法

Country Status (11)

Country Link
US (1) US6093836A (enExample)
EP (1) EP0909267B1 (enExample)
JP (1) JP3012005B2 (enExample)
KR (1) KR100270410B1 (enExample)
CN (1) CN1102139C (enExample)
AT (1) ATE209172T1 (enExample)
AU (1) AU6122698A (enExample)
DE (1) DE69803264T2 (enExample)
IN (1) IN188006B (enExample)
TW (1) TW513391B (enExample)
WO (1) WO1998039279A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107827726A (zh) * 2017-11-28 2018-03-23 辽宁中医药大学 马齿苋中化合物Oleracone E及其提取分离方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5128277B2 (ja) 2004-05-28 2013-01-23 ユニジェン・インコーポレーテッド 二核酵素の強力な阻害剤としてのジアリールアルカン類
US8362305B2 (en) 2008-07-21 2013-01-29 Unigen, Inc. Series of skin whitening (lightening) compounds
EP3822246A1 (en) 2011-03-24 2021-05-19 Unigen, Inc. Compounds and methods for preparation of diarylpropanes
CN103922979B (zh) * 2013-01-11 2016-05-25 卫生福利部国家中医药研究所 皮肤美白用化合物及皮肤用组成物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016293A1 (en) * 1990-04-18 1991-10-31 CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA RT Tó utca 1-5 Improved process for the preparation of ketone compounds
WO1994014477A1 (en) * 1992-12-21 1994-07-07 Mallinckrodt Medical, Inc. Polyhydric phenol compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU163394B (enExample) * 1971-12-20 1973-08-28
HU188239B (en) * 1982-12-28 1986-03-28 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for the production of new resorcinol-derivatives and of therapeutic preparations containing them
US5106871A (en) * 1986-12-12 1992-04-21 Tsumura & Co. Anti-ulcer agent comprising chalcone derivative as effective ingredient and novel chalcone derivative
JPH05503923A (ja) * 1989-10-19 1993-06-24 シェリング・コーポレーション リポキシゲナーゼインヒビター
CA2178914A1 (en) * 1994-07-27 1996-02-08 Yasunori Kitano Benzoylethylene derivative

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016293A1 (en) * 1990-04-18 1991-10-31 CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA RT Tó utca 1-5 Improved process for the preparation of ketone compounds
WO1994014477A1 (en) * 1992-12-21 1994-07-07 Mallinckrodt Medical, Inc. Polyhydric phenol compounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107827726A (zh) * 2017-11-28 2018-03-23 辽宁中医药大学 马齿苋中化合物Oleracone E及其提取分离方法
CN107827726B (zh) * 2017-11-28 2020-09-15 辽宁中医药大学 马齿苋中化合物Oleracone E及其提取分离方法

Also Published As

Publication number Publication date
AU6122698A (en) 1998-09-22
DE69803264T2 (de) 2002-08-08
IN188006B (enExample) 2002-08-03
DE69803264D1 (de) 2002-02-21
KR19980079558A (ko) 1998-11-25
JP3012005B2 (ja) 2000-02-21
EP0909267B1 (en) 2001-11-21
TW513391B (en) 2002-12-11
EP0909267A1 (en) 1999-04-21
US6093836A (en) 2000-07-25
ATE209172T1 (de) 2001-12-15
WO1998039279A1 (en) 1998-09-11
JPH11509239A (ja) 1999-08-17
KR100270410B1 (ko) 2000-11-01
CN1217709A (zh) 1999-05-26

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