TW513391B - Novel 1,3-diphenylpropane derivatives having inhibitory activity against tyrosinase and process for preparation thereof - Google Patents

Novel 1,3-diphenylpropane derivatives having inhibitory activity against tyrosinase and process for preparation thereof Download PDF

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Publication number
TW513391B
TW513391B TW087103180A TW87103180A TW513391B TW 513391 B TW513391 B TW 513391B TW 087103180 A TW087103180 A TW 087103180A TW 87103180 A TW87103180 A TW 87103180A TW 513391 B TW513391 B TW 513391B
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TW
Taiwan
Prior art keywords
compound
hydrogen
ethyl acetate
cns
formula
Prior art date
Application number
TW087103180A
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English (en)
Chinese (zh)
Inventor
Young-Ho Rhee
Kyung-Ae Kim
Hyun-Ho Lee
Jong-Kwon Choi
Sang-Hwa Lee
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Lg Chemical Ltd
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Filing date
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Publication of TW513391B publication Critical patent/TW513391B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/17—Saturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/172—Saturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW087103180A 1997-03-06 1998-03-05 Novel 1,3-diphenylpropane derivatives having inhibitory activity against tyrosinase and process for preparation thereof TW513391B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR19970007452 1997-03-06

Publications (1)

Publication Number Publication Date
TW513391B true TW513391B (en) 2002-12-11

Family

ID=19498891

Family Applications (1)

Application Number Title Priority Date Filing Date
TW087103180A TW513391B (en) 1997-03-06 1998-03-05 Novel 1,3-diphenylpropane derivatives having inhibitory activity against tyrosinase and process for preparation thereof

Country Status (11)

Country Link
US (1) US6093836A (enExample)
EP (1) EP0909267B1 (enExample)
JP (1) JP3012005B2 (enExample)
KR (1) KR100270410B1 (enExample)
CN (1) CN1102139C (enExample)
AT (1) ATE209172T1 (enExample)
AU (1) AU6122698A (enExample)
DE (1) DE69803264T2 (enExample)
IN (1) IN188006B (enExample)
TW (1) TW513391B (enExample)
WO (1) WO1998039279A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1748767B1 (en) 2004-05-28 2011-12-28 Unigen, Inc. 1-(3-methyl-2,4-dimethoxyphenyl)-3-(2',4'-dihydroxyphenyl)-propane as a potent tyrosinase inhibitor
ES2909484T3 (es) * 2008-07-21 2022-05-06 Unigen Inc Serie de compuestos para blanquear (aclarar) la piel
ES2859700T3 (es) 2011-03-24 2021-10-04 Unigen Inc Compuestos y métodos para la preparación de diarilpropanos
CN103922979B (zh) * 2013-01-11 2016-05-25 卫生福利部国家中医药研究所 皮肤美白用化合物及皮肤用组成物
CN107827726B (zh) * 2017-11-28 2020-09-15 辽宁中医药大学 马齿苋中化合物Oleracone E及其提取分离方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU163394B (enExample) * 1971-12-20 1973-08-28
HU188239B (en) * 1982-12-28 1986-03-28 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for the production of new resorcinol-derivatives and of therapeutic preparations containing them
WO1988004288A1 (fr) * 1986-12-12 1988-06-16 Tsumura Juntendo, Inc. Agent anti-ulcere contenant un derive de chalcone en tant qu'ingredient actif et nouveaux derives de chalcone
JPH05503923A (ja) * 1989-10-19 1993-06-24 シェリング・コーポレーション リポキシゲナーゼインヒビター
US5235109A (en) * 1990-04-18 1993-08-10 Chinoin Gyogyszer- Es Vegyeszeti Termekek Gyara Rt Process for the preparation of ketone compounds
DE69333611T2 (de) * 1992-12-21 2005-09-15 Mallinckrodt, Inc. Radiomarkierte mehrwertige phenolverbindungen
CA2178914A1 (en) * 1994-07-27 1996-02-08 Yasunori Kitano Benzoylethylene derivative

Also Published As

Publication number Publication date
EP0909267B1 (en) 2001-11-21
AU6122698A (en) 1998-09-22
JP3012005B2 (ja) 2000-02-21
WO1998039279A1 (en) 1998-09-11
JPH11509239A (ja) 1999-08-17
DE69803264D1 (de) 2002-02-21
ATE209172T1 (de) 2001-12-15
CN1217709A (zh) 1999-05-26
CN1102139C (zh) 2003-02-26
DE69803264T2 (de) 2002-08-08
IN188006B (enExample) 2002-08-03
EP0909267A1 (en) 1999-04-21
KR100270410B1 (ko) 2000-11-01
US6093836A (en) 2000-07-25
KR19980079558A (ko) 1998-11-25

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