CN110198713A - 一种银杏提取物药用原料及其制备方法 - Google Patents

一种银杏提取物药用原料及其制备方法 Download PDF

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CN110198713A
CN110198713A CN201780003764.8A CN201780003764A CN110198713A CN 110198713 A CN110198713 A CN 110198713A CN 201780003764 A CN201780003764 A CN 201780003764A CN 110198713 A CN110198713 A CN 110198713A
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巴卫松
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Natural Medicines & Medicinal Plants (AREA)
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  • Biotechnology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Organic Chemistry (AREA)
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  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

一种银杏提取物药用原料及其制备方法，银杏提取物药用原料包括将从银杏叶粗提物中提取的总内酯纯化品和总黄酮纯化品复配形成的混合物，总内酯纯化品内包括第一总内酯和第一总黄酮，总黄酮纯化品包括第二总内酯和第二总黄酮，在混合物中，第一总内酯和第二总内酯的总含量与第一总黄酮和第二总黄酮的总含量的比例为1‑2:1‑2。制备方法为：通过测定第一总内酯、第一总黄酮、第二总内酯和第二总黄酮的含量，然后按照上述比例对总内酯纯化品和总黄酮纯化品进行复配形混合物。

Description

PCT国内申请，说明书已公开。

Claims (11)

  1. PCT国内申请，权利要求书已公开。
CN201780003764.8A 2017-12-13 2017-12-13 一种银杏提取物药用原料及其制备方法 Pending CN110198713A (zh)

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PCT/CN2017/116018 WO2019113861A1 (zh) 2017-12-13 2017-12-13 一种银杏提取物药用原料及其制备方法

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CN110198713A true CN110198713A (zh) 2019-09-03

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CN (1) CN110198713A (zh)
DE (1) DE112017006865T5 (zh)
WO (1) WO2019113861A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115594654A (zh) * 2022-10-28 2023-01-13 河北荃美生物科技有限公司（Cn） 7-去甲基银杏双黄酮和银杏酮酯的提取方法及其应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111166775A (zh) * 2020-02-24 2020-05-19 巴卫松 银杏叶提取物、银杏叶提取物药剂及其应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013159572A (ja) * 2012-02-03 2013-08-19 Atsuyoshi Murakami 聴覚喪失予防用の組成物
US20160038550A1 (en) * 2014-07-22 2016-02-11 Craig E. Kinzer Methods and compositions for treating conditions associated with memory loss
CN105596382A (zh) * 2016-01-14 2016-05-25 重庆万物春生制药有限公司 一种银杏提取物的提取工艺
CN105960245A (zh) * 2014-02-10 2016-09-21 威玛舒培博士公司 用于生产银杏提取物的改进方法
CN106109510A (zh) * 2016-01-27 2016-11-16 河北润茂制药有限公司 精制银杏黄酮提取工艺
CN106727491A (zh) * 2016-12-08 2017-05-31 河北润茂制药有限公司 一种银杏酮酯药用原料

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1202832C (zh) * 2002-08-21 2005-05-25 浙江海正药业股份有限公司 一种高活性银杏叶提取物制剂和用途
CN101982172A (zh) * 2010-09-26 2011-03-02 江苏天安生物制药有限公司 一种银杏内酯与银杏黄酮组合药物及其制剂、应用
CN102283870B (zh) * 2011-09-09 2014-04-16 黑龙江珍宝岛药业股份有限公司 一种高纯度银杏叶组合物，含其制剂及其制备方法
CN105541861A (zh) * 2016-01-27 2016-05-04 河北润茂制药有限公司 精制银杏内酯提取工艺

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013159572A (ja) * 2012-02-03 2013-08-19 Atsuyoshi Murakami 聴覚喪失予防用の組成物
CN105960245A (zh) * 2014-02-10 2016-09-21 威玛舒培博士公司 用于生产银杏提取物的改进方法
US20160038550A1 (en) * 2014-07-22 2016-02-11 Craig E. Kinzer Methods and compositions for treating conditions associated with memory loss
CN105596382A (zh) * 2016-01-14 2016-05-25 重庆万物春生制药有限公司 一种银杏提取物的提取工艺
CN106109510A (zh) * 2016-01-27 2016-11-16 河北润茂制药有限公司 精制银杏黄酮提取工艺
CN106727491A (zh) * 2016-12-08 2017-05-31 河北润茂制药有限公司 一种银杏酮酯药用原料

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115594654A (zh) * 2022-10-28 2023-01-13 河北荃美生物科技有限公司（Cn） 7-去甲基银杏双黄酮和银杏酮酯的提取方法及其应用

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WO2019113861A1 (zh) 2019-06-20

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Application publication date: 20190903