CN110151608A - A kind of anti-acne compound essential oil and preparation method thereof - Google Patents
A kind of anti-acne compound essential oil and preparation method thereof Download PDFInfo
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- CN110151608A CN110151608A CN201910566658.1A CN201910566658A CN110151608A CN 110151608 A CN110151608 A CN 110151608A CN 201910566658 A CN201910566658 A CN 201910566658A CN 110151608 A CN110151608 A CN 110151608A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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Abstract
The invention discloses a kind of anti-acne compound essential oil and preparation method thereof, compound essential oil includes: 20-25wt% tea tree ethereal oil, the Rome 10-15wt% chamomile essential oil, 20-25wt% Lavender, 5-10wt% sandalwood essential oil, 1-3wt% cypress essential oil and 22-44wt% base oil.Essential oil provided by the invention is organic natural essential oil of extraction, prescription proportion science, safe without toxic side effect without any artificial synthesis group point.With anti-inflammatory, antibacterial and other effects, the pleomorphism skin lesion sheet such as face acne caused by acne, papule, warts, tubercle can be effectively relieved, there is the effect of preferable beauty and skin care.
Description
Technical field
The present invention relates to cosmetic technical fields, and in particular to a kind of anti-acne compound essential oil and preparation method thereof.
Background technique
Acne is also referred to as whelk, is a kind of chronic inflammatory skin of multiple pilosebaceous follicle that clinic is common.Tool
There is the features such as disease incidence is higher, easy recurrent exerbation.Acne causes the unsmooth institute of sebum outflow because of the blocking of sebaceous gland duct and pore
It causes.It is multiple to make in face, thoracic dorsal etc., the damage such as blackhead, papule, warts, tubercle is formed, to the social activity of patient, psychology, mood etc.
Aspect can affect.According to incompletely statistics, almost there is 90% more than 10 years old teenager that different serious journeys occurred
The acne of degree.In addition with the raising of the increase of externally-applied female cosmetics and gynecological disease such as pathogenesis of polycystic ovary syndrome rate,
Acne is also greatly increased in the disease incidence of female middle-aged.Therefore, acne is that one kind cannot be neglected psychosomatic disease, influences patient's
Quality of life.
Acne is a kind of multifactor disease, pathogenesis often with endocrine factors, the exception of pilosebaceous duct
Microorganism is related in angling and hair follicle, and immune factor, mental element, inherent cause etc. also risen in the morbidity of acne it is important
Effect.There are many drug and the treatment method for treating acne, and key agents have antibiotics, anti-androgens and tretinoin；It controls
Treatment method mainly have in control, external therapy.Clinic selects different method and drug generally according to the severity difference of acne.Slightly
Acne can single choice external drug, moderate acne selects antibiotic oral while external application, and antibiotic can be selected in severe acne
Or tretinoin oral medication.But have that side effect is more, and toxicity is big, it is not easy the disadvantages of eradicating.
Essential oil is a kind of natural skin-care nutrient liquid.It is that extraction is refined in the flower from plant, leaf, stem, root or fruit
Volatile flavor causes the change of allergy with without essence, without chemical pigment, without preservative, without mineral grease, nothing
Study point, adverse chemical ingredient the features such as.
Summary of the invention
In view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to provide a kind of anti-acne compound essential oil and preparation method thereof.
Essential oil provided by the invention selects the plant extract containing active skull cap components to form, and prescription proportion science does not add anyone
Work synthesizes component, safe without toxic side effect, and has significant anti-inflammatory, antibacterial, adjusts skin oil-water balance and enhancing human body
The effect of immunity, can be effectively relieved and cure the symptoms such as blackhead caused by acne, papule, warts, tubercle.In addition, of the invention
The essential oil of offer is highly-safe, stability is good, easy to use, is with a wide range of applications.
The purpose of the present invention is achieved through the following technical solutions: a kind of anti-acne compound essential oil, comprising: 20-
25wt% tea tree ethereal oil, the Rome 10-15wt% chamomile essential oil, 20-25wt% Lavender, 5-10wt% sandalwood essential oil,
1-3wt% cypress essential oil and 22-44wt% base oil.
Further, comprising: 20wt% tea tree ethereal oil, the Rome 10wt% chamomile essential oil, 20wt% Lavender,
5wt% sandalwood essential oil, 1wt% cypress essential oil and 44wt% base oil.
Further, the base oil is rose hip oil.
A kind of preparation method of above-mentioned composite essential oil, comprising the following steps:
(1) it after crushing santal, is extracted using supercritical carbon dioxide, reuses molecularly distilled and extract, obtain
Sandalwood essential oil；Extract -48 DEG C of temperature 45 C, pressure 13.70MPa-17.80MPa of the supercritical carbon dioxide, time is
50min-100min, the flow velocity of carbon dioxide are 25kg/h-35kg/h；The feeding temperature of the molecularly distilled is 40 DEG C -45
DEG C, sample introduction speed is 480-530mL/h, and one section of evaporating temperature is 110 DEG C -115 DEG C, and dual circulation temperature is 60 DEG C -65 DEG C.
(2) it is extracted, is obtained using steam distillation after crushing tea tree, Rome chamomile, lavender, cypress respectively
To tea tree ethereal oil, Rome chamomile essential oil, Lavender, cypress essential oil；The liquid-to-solid ratio of the steam distillation is 3-
7ml:1g, vapo(u)rizing temperature are 100 DEG C -120 DEG C, and distillation time is 5-7 hours.
(3) fructus rosae crushing is placed in squeezer and is squeezed, crude oil is collected by filtration and is refined using molecularly distilled, obtains
Base oil；The feeding temperature of the molecularly distilled is 40 DEG C -45 DEG C, and sample introduction speed is 480-530mL/h, one section of evaporating temperature
It is 110 DEG C -115 DEG C, dual circulation temperature is 60 DEG C -65 DEG C.
(4) sandalwood essential oil for obtaining step 1, tea tree ethereal oil that step 2 obtains, Rome chamomile essential oil, lavender essence
The base oil that oil, cypress essential oil and step 3 obtain is uniformly mixed, and obtains compound essential oil；In compound essential oil, the quality of each component is matched
Than are as follows: 20-25wt% tea tree ethereal oil, the Rome 10-15wt% chamomile essential oil, 20-25wt% Lavender, 5-10wt% wingceltis
Essential oil, 1-3wt% cypress essential oil and 22-44wt% base oil.
The beneficial effects of the present invention are: the present invention provides a kind of preparation method of compound essential oil, this method process stabilizing,
Yield is high, quality is good, low energy consumption.Essential oil provided by the invention selects the plants essential oil extract composition containing active skull cap components
It forms, prescription proportion science does not add any artificial synthesis group point.Through human body and animal Efficacy experiments, toxicological test and metabolism
Experimental study shows the essential oil being prepared using method provided by the invention, and safe without toxic side effect absorbs fastly, and has
The effect of significant anti-inflammatory, antibacterial, adjusting oil-water balance etc. are alleviated or treat acne.Essential oil provided by the invention is easy to use, directly
It connects and is applied to acne spots, massage absorbs, that is, can reach excellent curative effect.
Specific embodiment
The embodiment of technical solution of the present invention will be described in detail below.Following embodiment is only used for clearer
Illustrate technical solution of the present invention, therefore be only used as example, and not intended to limit the protection scope of the present invention.
The present invention provides a kind of preparation method of compound essential oil, and raw material components include tea tree ethereal oil 20- by weight
25 parts by weight, Rome chamomile essential oil 10-15 parts by weight, Lavender 20-25 parts by weight, sandalwood essential oil 5-10 parts by weight,
Cypress essential oil 1-3 parts by weight and base oil 44-22 parts by weight.
Compound essential oil of the invention can also be formulated by raw material components by directly buying above-mentioned plants essential oil,
Method can be prepared as follows to obtain: after sandalwood essential oil is extracted using supercritical carbon dioxide, reusing molecularly distilled progress
It extracts；It is extracted after mixing using steam distillation after tea tree, Rome chamomile, lavender, cypress are crushed；It will
Squeezing method extracts after fructus rosae crushes, and freezing and filtering, obtains base oil；The extraction of essential oil object is mixed with the base oil
It is even, obtain compound essential oil.
It is illustrated With reference to embodiment:
Embodiment 1:
Take 20 parts by weight of tea tree ethereal oil, 10 parts by weight of Rome chamomile essential oil, 20 parts by weight of Lavender, sandalwood essential oil
44 parts by weight of 5 parts by weight, 1 parts by weight of cypress essential oil and rose hip oil are uniformly mixed to obtain the final product.
Embodiment 2:
Take 25 parts by weight of tea tree ethereal oil, 15 parts by weight of Rome chamomile essential oil, 25 parts by weight of Lavender, sandalwood essential oil
22 parts by weight of 10 parts by weight, 3 parts by weight of cypress essential oil and rose hip oil are uniformly mixed to obtain the final product.
Embodiment 3:
Take 23 parts by weight of tea tree ethereal oil, 12 parts by weight of Rome chamomile essential oil, 23 parts by weight of Lavender, sandalwood essential oil
32 parts by weight of 8 parts by weight, 2 parts by weight of cypress essential oil and rose hip oil are uniformly mixed to obtain the final product.
Embodiment 4:
Santal is taken to extract using supercritical carbon dioxide, temperature is 45 DEG C, pressure 13.70MPa, time 50min, stream
Speed is 25kg/h；By extract using molecular distillation, feeding temperature is 40 DEG C, and sample introduction speed is 480mL/h, one section of evaporation temperature
Degree is 110 DEG C, and dual circulation temperature is 60 DEG C, obtains sandalwood essential oil；Tea tree, Rome chamomile, lavender, cypress are crushed respectively
Afterwards, it is extracted using steam distillation, the liquid-to-solid ratio of the steam distillation is 7ml:1g, that is, the water being added is to plant
7 times of object example weight ratio, 100 degree of vapo(u)rizing temperature, distillation time is 5 hours, obtains tea tree ethereal oil, Rome chamomile essential oil, smokes
Clothing grass essential oil, cypress essential oil；Fructus rosae is crushed and is placed in squeezer for coarse granule, squeeze and filter obtains crude oil, and crude oil passes through again
Molecular distillation, feeding temperature are 40 DEG C, and sample introduction speed is 480mL/h, and one section of evaporating temperature is 110 DEG C, and dual circulation temperature is
60 DEG C, two sections of distillates are collected, base oil is obtained；By 25 parts by weight of tea tree ethereal oil, 15 parts by weight of Rome chamomile essential oil, lavender
25 parts by weight of essential oil, 10 parts by weight of sandalwood essential oil, 3 parts by weight of cypress essential oil and the mixing of 22 parts by weight extract of rose hip oil are equal
It is even, obtain compound essential oil.
Embodiment 5:
Santal is taken to extract using supercritical carbon dioxide, temperature is 45 DEG C, pressure 13.70MPa, time 50min, stream
Speed is 25kg/h；By extract using molecular distillation, feeding temperature is 40 DEG C, and sample introduction speed is 480mL/h, one section of evaporation temperature
Degree is 110 DEG C, and dual circulation temperature is 60 DEG C, obtains sandalwood essential oil；Tea tree, Rome chamomile, lavender, cypress are crushed respectively
It is extracted afterwards using steam distillation, the liquid-to-solid ratio of the steam distillation is 6ml:1g, that is, the water being added is to plant
6 times of object example weight ratio, distillation time are 5 hours, obtain tea tree ethereal oil, Rome chamomile essential oil, Lavender, cypress essence
Oil；Squeezing method extracts after fructus rosae is crushed, then obtains base oil through molecular distillation；20 parts by weight of tea tree ethereal oil, Rome ocean is sweet
10 parts by weight of chrysanthemum essential oil, 20 parts by weight of Lavender, 5 parts by weight of sandalwood essential oil, 1 parts by weight of cypress essential oil and rose hip oil 44
Parts by weight are uniformly mixed, and obtain compound essential oil.
Embodiment 6:
Santal is taken to extract using supercritical carbon dioxide, temperature is 48 DEG C, pressure 13.70MPa, time 280min,
Flow velocity is 25kg/h；By extract using molecular distillation, feeding temperature is 45 DEG C, and sample introduction speed is 460mL/h, one section of evaporation
Temperature is 115 DEG C, and dual circulation temperature is 60 DEG C, obtains sandalwood essential oil；Tea tree, Rome chamomile, lavender, cypress are distinguished into powder
It is extracted after broken using steam distillation, distillation time is 5 hours, obtains plants essential oil；Squeezing method after fructus rosae is crushed
It extracts, then obtains base oil through molecular distillation, obtain base oil；By 20 parts by weight of tea tree ethereal oil, 10 parts by weight of Rome chamomile essential oil,
20 parts by weight of Lavender, 44 parts by weight of 5 parts by weight of sandalwood essential oil, 1 parts by weight of cypress essential oil and rose hip oil, mixing are equal
It is even, obtain compound essential oil.
Embodiment 7:
Antibacterial experiment:
Peptone 5g, yeast 2.5g, sodium chloride 5g, water 500ML prepare fluid nutrient medium in proportion, are placed in 500mL taper
It is spare after sterilizing in bottle；Compound essential oil sample is dissolved with DMSO, the essential oil dilution that fluid nutrient medium is formulated as 30 μ g/mL is added
Liquid.Then, it is inoculated with propionibacterium acnes (Propionibacterium acnes) on the super-clean bench of sterilizing, is put into shaking table and (turns
Speed 131,37 degrees Celsius of temperature) after 12 hours of middle culture, the essential oil smaple diluted is added in 96 orifice plates, every hole adds 10
μ L is repeated to add 3 holes, while erythromycin positive controls and blank control is arranged, and then 90 μ L bacterium solutions are added in each Confucius, is added
It is complete to be placed on culture 24 hours in incubator.Using mtt assay, the antibacterial activity of microplate reader test compound essential oil is used.It can be with from table 1
Find out, the compound essential oil in example 1-6 all has the activity for inhibiting propionibacterium acnes in various degree.
1 antibacterial experiment result of table
| Sample ID | IC50(μg/mL) |
| Compound essential oil in example 1 | 15.7±0.4 |
| Compound essential oil in example 2 | 5.9±0.3 |
| Compound essential oil in example 3 | 10.1±0.5 |
| Compound essential oil in example 4 | 12.8±0.8 |
| Compound essential oil in example 5 | 8.1±0.2 |
| Compound essential oil in example 6 | 9.5±0.4 |
| Erythromycin | 3.2±0.1 |
Anti-inflammatory experiment:
We induce RAW264.7 cell for lipopolysaccharides (LPS) using Griess method and ELISA method test compound essential oil
The effect that middle NO and TNF-α generate, to evaluate the anti-inflammatory activity of compound essential oil.By RAW264.7 cell recovery, it is suitable to be passaged to
Density and in good condition, cell piping and druming uniformly, count under microscope, adjustment cell density to 2 × 105/ml.By every 100 μ of hole
L i.e. 2 × 104/hole kind plate, are incubated for 18h by 37 DEG C, 5%CO2, after removing serum 6h, add each acute drug and LPS to stimulate (overall
It is 200 μ l), after 18h, 100 μ l supernatants are taken, after detecting NO with Griess method, supernatant is taken out and carries out TNF-α detection.Note
Record the absorbance value under each concentration, and according to formula inhibiting rate=(model group-dosing group)/(model group-control group) ×
100% calculates the inhibiting rate that each group generates NO and TNF-α, recycles IC50Software for calculation calculates the IC of each compound50
Value.From table 2 it can be seen that the compound essential oil in example 1-6 all has significant anti-inflammatory activity, it is better than folk prescription tea tree ethereal oil.
The anti-inflammatory experimental result of table 2
Human experimentation:
Collection adolescent acne volunteer 300, each patient do not have to degree with face acne caused by acne,
The pleomorphism skin lesion such as papule, warts, tubercle.Each patient is divided into 3 groups, every group 100.First group of smearing embodiment of the present invention
Two compound essential oil (administration group), second group of smearing fructus rosae base oil (blank control group), third group smear tea tree ethereal oil (sun
Property control group).Smearing method is 2 times a day (once in the morning and once at night), to be uniformly applied to affected part every time；Respectively at 3rd day on probation,
Curative effect is observed at the 7th day, the 15th day and the 30th day.It is administered using double-blind study, does not occur skin irritatin or allergic phenomena.Specifically such as
Shown in table 3.From table 3 it can be seen that the compound essential oil in example 2 can effectively improve face acne, papule, warts, tubercle multiform
Property the symptoms such as skin lesion, adjust skin acne problem.
The curative effect in acne is being alleviated or alleviated to each embodiment essential oil of table 3
Curative effect judgement are as follows: cure: the symptoms such as face acne, papule, warts, tubercle pleomorphism skin lesion disappear, and skin restores
Health.Improve: the pleomorphism skin lesion symptom such as face acne, papule, warts, tubercle makes moderate progress, statistically significant P < 0.05.
Effective: the pleomorphism skin lesion symptom such as pleomorphism skin lesion such as face acne, papule, warts, tubercle has certain improvement, but without statistics
Meaning, P > 0.05；Invalid: symptom is without changer.
Claims (4)
1. a kind of anti-acne compound essential oil characterized by comprising 20-25wt% tea tree ethereal oil, the Rome 10-15wt% chamomile
Essential oil, 20-25wt% Lavender, 5-10wt% sandalwood essential oil, 1-3wt% cypress essential oil and 22-44wt% base oil.
2. anti-acne compound essential oil according to claim 1 characterized by comprising 20wt% tea tree ethereal oil, the Rome 10wt%
Chamomile essential oil, 20wt% Lavender, 5wt% sandalwood essential oil, 1wt% cypress essential oil and 44wt% base oil.
3. anti-acne compound essential oil according to claim 1, which is characterized in that the base oil is rose hip oil.
4. a kind of preparation method of composite essential oil described in claim 1, which comprises the following steps:
(1) it after crushing santal, is extracted using supercritical carbon dioxide, reuses molecularly distilled and extract, obtain santal
Essential oil；Extract -48 DEG C of temperature 45 C, pressure 13.70MPa-17.80MPa of the supercritical carbon dioxide, time is
50min-100min, the flow velocity of carbon dioxide are 25kg/h-35kg/h；The feeding temperature of the molecularly distilled is 40 DEG C -45
DEG C, sample introduction speed is 480-530mL/h, and one section of evaporating temperature is 110 DEG C -115 DEG C, and dual circulation temperature is 60 DEG C -65 DEG C.
(2) it is extracted after crushing tea tree, Rome chamomile, lavender, cypress respectively using steam distillation, obtains tea
Set essential oil, Rome chamomile essential oil, Lavender, cypress essential oil；The liquid-to-solid ratio of the steam distillation is 3-7ml:1g,
Vapo(u)rizing temperature is 100 DEG C -120 DEG C, and distillation time is 5-7 hours.
(3) fructus rosae crushing is placed in squeezer and is squeezed, crude oil is collected by filtration and is refined using molecularly distilled, obtains basic
Oil；The feeding temperature of the molecularly distilled is 40 DEG C -45 DEG C, and sample introduction speed is 480-530mL/h, and one section of evaporating temperature is
110 DEG C -115 DEG C, dual circulation temperature is 60 DEG C -65 DEG C.
(4) sandalwood essential oil for obtaining step 1, tea tree ethereal oil that step 2 obtains, Rome chamomile essential oil, Lavender, silk
The base oil that cypress essential oil and step 3 obtain is uniformly mixed, and obtains compound essential oil；In compound essential oil, the quality proportioning of each component are as follows:
20-25wt% tea tree ethereal oil, the Rome 10-15wt% chamomile essential oil, 20-25wt% Lavender, 5-10wt% santal essence
Oil, 1-3wt% cypress essential oil and 22-44wt% base oil.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114272296A (en) * | 2021-11-23 | 2022-04-05 | 广州国色天香生物科技有限公司 | Plant compound essential oil for removing mites and acnes and preparation method thereof |
| CN115670980A (en) * | 2022-10-26 | 2023-02-03 | 梵申兰科技(上海)有限公司 | Compound essential oil with skin protection effect and skin care product composition containing same |
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2019
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114272296A (en) * | 2021-11-23 | 2022-04-05 | 广州国色天香生物科技有限公司 | Plant compound essential oil for removing mites and acnes and preparation method thereof |
| CN115670980A (en) * | 2022-10-26 | 2023-02-03 | 梵申兰科技(上海)有限公司 | Compound essential oil with skin protection effect and skin care product composition containing same |
| CN115670980B (en) * | 2022-10-26 | 2024-02-27 | 梵申兰科技(上海)有限公司 | Compound essential oil with skin protection effect and skin care product composition containing compound essential oil |
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