CN110179696A - A kind of assisting sleep compound essential oil and preparation method thereof - Google Patents
A kind of assisting sleep compound essential oil and preparation method thereof Download PDFInfo
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- CN110179696A CN110179696A CN201910567102.4A CN201910567102A CN110179696A CN 110179696 A CN110179696 A CN 110179696A CN 201910567102 A CN201910567102 A CN 201910567102A CN 110179696 A CN110179696 A CN 110179696A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/84—Valerianaceae (Valerian family), e.g. valerian
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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Abstract
The invention discloses a kind of assisting sleep compound essential oil and preparation method thereof, compound essential oil includes: 20-25wt% valerian essential oil, 20-25wt% Lavender, 5-10wt% sandalwood essential oil, 11-18wt% refined jasmine oil and 22-44wt% base oil.Essential oil provided by the invention is organic natural essential oil of extraction without any artificial synthesis group point, and prescription proportion is scientific, and safe without toxic side effect can effectively extend the time of deep sleep, has effects that preferably to improve sleep.
Description
Technical field
The present invention relates to cosmetic technical fields, and in particular to a kind of assisting sleep compound essential oil and preparation method thereof.
Background technique
With the quickening of modern life rhythm, people's operating pressure increases, and sleep disturbance occur in more and more crowds.It loses
Sleeping becomes a kind of very common phenomenon, and cardinal symptom has: difficulty falling asleep, sleep quality are low, sleeping time is short, and serious person is all night
Egersis.Chronic insomnia can cause physiological dysfunction, fatigue and weak, failure of memory, it is serious be also possible to cause it is some bad
Symptom induces psychosomatic.In addition, the change of busy work and life environment also brings along sleep quality decline.
Insomnia is a kind of multifactor disease, and mental element, inherent cause etc. have also risen in the morbidity of insomnia important
Effect.There are many drug and the treatment method for treating insomnia, key agents have including Benzodiazepines receptor stimulating agent, epiphysin by
Body agonist and the antidepressant with hypnotic effect etc. also have and are slept by physical therapies such as repetitive transcranial magnetic stimulations to improve
It sleeps.But have that side effect is more, and toxicity is big, it is not easy to eradicate etc. and determines.
Essential oil is a kind of natural skin-care nutrient liquid.It is that extraction is refined in the flower from plant, leaf, stem, root or fruit
Volatile flavor causes the change of allergy with without essence, without chemical pigment, without preservative, without mineral grease, nothing
Study point, adverse chemical ingredient the features such as.
Summary of the invention
In view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to provide a kind of assisting sleep compound essential oil and its preparation side
Method.Essential oil provided by the invention selects the plant extract containing active skull cap components to form, and prescription proportion science is not added any
Artificial synthesized component, safe without toxic side effect, and have effects that significantly to extend deep sleep.Essential oil safety provided by the invention
Property it is high, stability is good, easy to use, be with a wide range of applications.
The purpose of the present invention is achieved through the following technical solutions: a kind of assisting sleep compound essential oil, comprising: 20-
25wt% valerian essential oil, 20-25wt% Lavender, 5-10wt% sandalwood essential oil, 11-18wt% refined jasmine oil and 22-
44wt% base oil.
Further, comprising: 20wt% valerian essential oil, 20wt% Lavender, 5wt% sandalwood essential oil, 11wt% jasmine
Jasmine essential oil and 44wt% base oil.
Further, the base oil is rose hip oil.
A kind of preparation method of compound essential oil described in claim 1, comprising the following steps:
(1) it after crushing santal and jasmine respectively, is extracted using supercritical carbon dioxide, reuses molecularly distilled progress
It extracts, obtains sandalwood essential oil and refined jasmine oil；- 48 DEG C of temperature 45 C of the supercritical carbon dioxide extraction, pressure are
13.70MPa-17.80MPa, time 50min-100min, the flow velocity of carbon dioxide are 25kg/h-35kg/h；The molecule steams
The feeding temperature for evaporating method is 40 DEG C -45 DEG C, and sample introduction speed is 480-530mL/h, and one section of evaporating temperature is 110 DEG C -115 DEG C, two
Section evaporating temperature is 60 DEG C -65 DEG C.
(2) by valerian and lavender powder it is broken respectively after extracted using steam distillation, obtain valerian essential oil and smoke
Clothing grass essential oil；The liquid-to-solid ratio of the steam distillation is 3-7ml:1g, and vapo(u)rizing temperature is 100 DEG C -120 DEG C, and distillation time is
5-7 hours.
(3) fructus rosae crushing is placed in squeezer and is squeezed, crude oil is collected by filtration, is refined using molecularly distilled,
Obtain base oil；The feeding temperature of the molecularly distilled is 40 DEG C -45 DEG C, and sample introduction speed is 480-530mL/h, one section of evaporation temperature
Degree is 110 DEG C -115 DEG C, and dual circulation temperature is 60 DEG C -65 DEG C.
(4) the valerian essential oil and Lavender that obtain sandalwood essential oil and refined jasmine oil that step 1 obtains, step 2 and
The base oil that step 3 obtains is uniformly mixed, and obtains compound essential oil；In compound essential oil, the quality proportioning of each component are as follows: 20-
25wt% valerian essential oil, 20-25wt% Lavender, 5-10wt% sandalwood essential oil, 11-18wt% refined jasmine oil and 22-
44wt% base oil.
The beneficial effects of the present invention are: the present invention provides a kind of preparation method of compound essential oil, this method process stabilizing,
Yield is high, quality is good, low energy consumption.Essential oil provided by the invention selects the plants essential oil extract composition containing active skull cap components
It forms, prescription proportion science does not add any artificial synthesis group point.Through human body and animal Efficacy experiments, toxicological test and metabolism
Experimental study shows the essential oil being prepared using method provided by the invention, and safe without toxic side effect absorbs fastly, and has
The effect of significantly improving sleep.Essential oil provided by the invention is easy to use, and directly drop on pillow or is added dropwise in fumigating machine
It is stifling to use.
Specific embodiment
The embodiment of technical solution of the present invention will be described in detail below.Following embodiment is only used for clearer
Illustrate technical solution of the present invention, therefore be only used as example, and not intended to limit the protection scope of the present invention.
The present invention provides a kind of preparation method of compound essential oil, and raw material components include valerian essential oil 20- by weight
25 parts by weight, Lavender 20-25 parts by weight, sandalwood essential oil 5-10 parts by weight, refined jasmine oil 11-18 parts by weight and base oil
44-22 parts by weight.
Compound essential oil of the invention can also be formulated by raw material components by directly buying above-mentioned plants essential oil,
Method can be prepared as follows to obtain: sandalwood essential oil and refined jasmine oil are respectively adopted after supercritical carbon dioxide extracts, and reuse
Molecularly distilled extracts；It is extracted after valerian and lavender are crushed respectively using steam distillation；By fructus rosae
Squeezing method extracts after crushing, and freezing and filtering, obtains base oil；The extraction of essential oil object is uniformly mixed with the base oil, is obtained
To compound essential oil.
It is illustrated With reference to embodiment:
Embodiment 1:
20 parts by weight of valerian essential oil, 20 parts by weight of Lavender, 5 parts by weight of sandalwood essential oil, 11 parts by weight of refined jasmine oil
With 44 parts by weight of base oil, it is uniformly mixed to obtain the final product.
Embodiment 2:
Take 25 parts by weight of valerian essential oil, 25 parts by weight of Lavender, 10 parts by weight of sandalwood essential oil, 18 weight of refined jasmine oil
Part and 22 parts by weight of rose hip oil are uniformly mixed to obtain the final product.
Embodiment 3:
Supercritical carbon dioxide is respectively adopted in santal and jasmine to extract, temperature is 45 DEG C, pressure 13.70MPa, the time
For 50min, flow velocity 25kg/h；By extract again into molecular distillation is crossed, feeding temperature is 40 DEG C, and sample introduction speed is 480mL/h,
One section of evaporating temperature is 110 DEG C, and dual circulation temperature is 60 DEG C, obtains sandalwood essential oil and refined jasmine oil；By valerian, lavender, silk
Cypress is extracted after crushing respectively using steam distillation, and the liquid-to-solid ratio of the steam distillation is 7ml:1g, that is, is added
Water be 7 times of plant sample weight ratio, 100 degree of vapo(u)rizing temperature, distillation time is 5 hours, obtains plants essential oil；By fructus rosae
Crushing is that coarse granule is placed in squeezer, and squeeze and filter obtains crude oil, and for crude oil again through molecular distillation, feeding temperature is 40 DEG C, into
Sample speed is 480mL/h, and one section of evaporating temperature is 110 DEG C, and dual circulation temperature is 60 DEG C, collects two sections of distillates, obtains basic
Oil；By above-mentioned extraction of essential oil object and basic oil extract by 25 parts by weight of valerian essential oil, 25 parts by weight of Lavender, santal essence
Oily 10 parts by weight, 18 parts by weight of refined jasmine oil and 22 parts by weight of rose hip oil are uniformly mixed, and obtain compound essential oil.
Embodiment 4:
Assisting sleep experiment:
It extracts 100 triers and carries out double blind using test experiments, 60% trier uses embodiment 1-3 compound essential oil
Afterwards, highly significant extends the deep sleep time；After 25% trier uses embodiment 1-3 compound essential oil, significantly extend
The deep sleep time；After 15% trier uses embodiment 1-3 compound essential oil, extend the time indifference of deep sleep.
Claims (4)
1. a kind of assisting sleep compound essential oil characterized by comprising 20-25wt% valerian essential oil, 20-25wt% lavender
Essential oil, 5-10wt% sandalwood essential oil, 11-18wt% refined jasmine oil and 22-44wt% base oil.
2. assisting sleep compound essential oil according to claim 1 characterized by comprising 20wt% valerian essential oil, 20wt%
Lavender, 5wt% sandalwood essential oil, 11wt% refined jasmine oil and 44wt% base oil.
3. assisting sleep compound essential oil according to claim 1, which is characterized in that the base oil is rose hip oil.
4. a kind of preparation method of compound essential oil described in claim 1, which comprises the following steps:
(1) it after crushing santal and jasmine respectively, is extracted using supercritical carbon dioxide, reuses molecularly distilled and mentioned
It takes, obtains sandalwood essential oil and refined jasmine oil；- 48 DEG C of temperature 45 C of the supercritical carbon dioxide extraction, pressure are
13.70MPa-17.80MPa, time 50min-100min, the flow velocity of carbon dioxide are 25kg/h-35kg/h；The molecule steams
The feeding temperature for evaporating method is 40 DEG C -45 DEG C, and sample introduction speed is 480-530mL/h, and one section of evaporating temperature is 110 DEG C -115 DEG C, two
Section evaporating temperature is 60 DEG C -65 DEG C.
(2) by valerian and lavender powder it is broken respectively after extracted using steam distillation, obtain valerian essential oil and lavender
Essential oil；The liquid-to-solid ratio of the steam distillation is 3-7ml:1g, and vapo(u)rizing temperature is 100 DEG C -120 DEG C, and distillation time is that 5-7 is small
When.
(3) fructus rosae crushing is placed in squeezer and is squeezed, crude oil is collected by filtration, is refined using molecularly distilled, obtains base
Plinth oil；The feeding temperature of the molecularly distilled is 40 DEG C -45 DEG C, and sample introduction speed is 480-530mL/h, and one section of evaporating temperature is
110 DEG C -115 DEG C, dual circulation temperature is 60 DEG C -65 DEG C.
(4) the valerian essential oil and Lavender and step 3 obtained sandalwood essential oil and refined jasmine oil that step 1 obtains, step 2
Obtained base oil is uniformly mixed, and obtains compound essential oil；In compound essential oil, the quality proportioning of each component are as follows: 20-25wt% valerian
Essential oil, 20-25wt% Lavender, 5-10wt% sandalwood essential oil, 11-18wt% refined jasmine oil and 22-44wt% base oil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201910567102.4A CN110179696A (en) | 2019-06-27 | 2019-06-27 | A kind of assisting sleep compound essential oil and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910567102.4A CN110179696A (en) | 2019-06-27 | 2019-06-27 | A kind of assisting sleep compound essential oil and preparation method thereof |
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| Publication Number | Publication Date |
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| CN110179696A true CN110179696A (en) | 2019-08-30 |
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| CN201910567102.4A Withdrawn CN110179696A (en) | 2019-06-27 | 2019-06-27 | A kind of assisting sleep compound essential oil and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110613805A (en) * | 2019-10-18 | 2019-12-27 | 成都瑞事吉事商贸有限公司 | Compound essential oil with calming and sleep-aiding effects and preparation method thereof |
| CN111388572A (en) * | 2020-04-13 | 2020-07-10 | 北京中医药大学 | Compound essential oil and preparation method, preparation and application thereof |
| CN112021696A (en) * | 2020-09-08 | 2020-12-04 | 东莞市华佑医疗科技有限公司 | Medical mask of traditional Chinese medicine aromatherapy essential oil compound for improving sleep |
| CN112891469A (en) * | 2019-12-04 | 2021-06-04 | 杨春辉 | Compound essential oil for improving sleep quality |
| CN114762709A (en) * | 2021-05-21 | 2022-07-19 | 品高生物科技(广州)有限公司 | Plant essential oil for improving sleep and preparation method and use method thereof |
-
2019
- 2019-06-27 CN CN201910567102.4A patent/CN110179696A/en not_active Withdrawn
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110613805A (en) * | 2019-10-18 | 2019-12-27 | 成都瑞事吉事商贸有限公司 | Compound essential oil with calming and sleep-aiding effects and preparation method thereof |
| CN112891469A (en) * | 2019-12-04 | 2021-06-04 | 杨春辉 | Compound essential oil for improving sleep quality |
| CN111388572A (en) * | 2020-04-13 | 2020-07-10 | 北京中医药大学 | Compound essential oil and preparation method, preparation and application thereof |
| CN112021696A (en) * | 2020-09-08 | 2020-12-04 | 东莞市华佑医疗科技有限公司 | Medical mask of traditional Chinese medicine aromatherapy essential oil compound for improving sleep |
| CN114762709A (en) * | 2021-05-21 | 2022-07-19 | 品高生物科技(广州)有限公司 | Plant essential oil for improving sleep and preparation method and use method thereof |
| CN114762709B (en) * | 2021-05-21 | 2023-11-24 | 品高生物科技(广州)有限公司 | Plant essential oil for improving sleep and preparation method and application method thereof |
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