CN110179694A - A kind of scar repairs compound essential oil and preparation method thereof - Google Patents
A kind of scar repairs compound essential oil and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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Abstract
The invention discloses a kind of scars to repair compound essential oil and preparation method thereof, and compound essential oil includes: the permanent flower essential oil of 20-25wt%, 10-15wt% olibanum essential oil, 20-25wt% Lavender, 5-10wt% tea tree ethereal oil, 1-3wt% Pogostemon cablin essential and 44-22wt% base oil.Essential oil provided by the invention is organic natural essential oil of extraction, prescription proportion science, safe without toxic side effect without any artificial synthesis group point.With soften rapidly, disintegrate scar tissue, promote scar at necrosis cell tissue update regeneration and other effects, the factors such as physics, biology, chemistry, which can be effectively relieved, to be led to the serious damage of skin soft tissue and completely voluntarily normal cannot repair, the appearance that influences for turning to be left by fibrous tissue replacement reparation influences the local symptom of function again, has the effect of preferable beauty and skin care.
Description
Technical field
The present invention relates to cosmetic technical fields, and in particular to a kind of scar is repaired compound essential oil and preparation method thereof and answered
With.
Background technique
Scar is the detrimental effect of the factors such as physics, biology, chemistry in human skin soft tissue, leads to skin soft tissue
It seriously damages and completely voluntarily normal cannot repair, the i.e. influence appearance for turning to be left by fibrous tissue replacement reparation influences function again
Local symptom." scar " is huge human body pain and mental suffering to patient's bring, especially burns, scalds, wound
The scar left afterwards etc..Several years of scar hyperplasia phase almost allow patient to suffer untold misery.The atrophy phase then makes patient face again
Mesh is entirely non-, dysfunction, causes the great body of patient, heart double combination obstacle.
Scar is relatively conventional health problem.Main improvement or treatment method have gene therapy, drug note in scar
Penetrate, take orally anti-scar drug, cold therapy, pressure therapy, laser therapy, silicate gel film class product, radiotherapy etc., it is various to control
The therapeutic effect for the treatment of mode is also not quite similar.But have that the period is long, is not easy to eradicate, the disadvantages of toxic side effect is big.
Essential oil is a kind of natural skin-care nutrient liquid.It is that extraction is refined in the flower from plant, leaf, stem, root or fruit
Volatile flavor causes the change of allergy with without essence, without chemical pigment, without preservative, without mineral grease, nothing
Study point, adverse chemical ingredient the features such as.
Summary of the invention
In view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to which providing a kind of scar repairs compound essential oil and its preparation side
Method and application.Essential oil provided by the invention selects the plant extract containing active skull cap components to form, and prescription proportion science does not add
Add any artificial synthesis group point, safe without toxic side effect, and there is significant anti-inflammatory, antibacterial, adjust skin oil-water balance and
The effect of enhancing human immunity, the scar that can be effectively relieved and be left after Burn, scald, wound etc..In addition, of the invention
The essential oil of offer is highly-safe, stability is good, easy to use, is with a wide range of applications.
The purpose of the present invention is achieved through the following technical solutions: a kind of scar reparation compound essential oil, comprising: 20-
The permanent flower essential oil of 25wt%, 10-15wt% olibanum essential oil, 20-25wt% Lavender, 5-10wt% tea tree ethereal oil, 1-
3wt% Pogostemon cablin essential and 22-44wt% base oil.
Further, comprising: the permanent flower essential oil of 20wt%, 10wt% olibanum essential oil, 20wt% Lavender, 5wt%
Tea tree ethereal oil, 1wt% Pogostemon cablin essential and 44wt% base oil.
Further, the base oil is rose hip oil.
A kind of preparation method of above-mentioned compound essential oil, comprising the following steps:
(1) after crushing permanent flower and olibanum respectively, extracted using supercritical carbon dioxide, reuse molecularly distilled into
Row purification, obtains permanent flower essential oil and olibanum essential oil；The temperature that the supercritical carbon dioxide extracts is 45 DEG C -48 DEG C, pressure
For 13.70MPa-17.80MPa, time 50min-100min, the flow velocity of carbon dioxide is 25kg/h-35kg/h；The molecule
The feeding temperature of the way of distillation is 40 DEG C -45 DEG C, and sample introduction speed is 480-530mL/h, and one section of evaporating temperature is 110 DEG C -115 DEG C,
Dual circulation temperature is 60 DEG C -65 DEG C.
(2) it is extracted after crushing lavender, tea tree, Pogostemon cablin respectively using steam distillation, obtains lavender
Essential oil, tea tree ethereal oil, Pogostemon cablin essential；The liquid-to-solid ratio of the steam distillation be 3-7ml:1g, vapo(u)rizing temperature be 100 DEG C-
120 DEG C, distillation time is 5-7 hours.
(3) fructus rosae crushing is placed in squeezer and is squeezed, crude oil is collected by filtration, is refined using molecularly distilled,
Obtain base oil；The feeding temperature of the molecularly distilled is 40 DEG C -45 DEG C, and sample introduction speed is 480-530mL/h, one section of evaporation temperature
Degree is 110 DEG C -115 DEG C, and dual circulation temperature is 60 DEG C -65 DEG C.
(4) by the permanent flower essential oil that step 1 obtains and the Lavender that olibanum essential oil, step 2 obtain, tea tree ethereal oil,
The base oil that Pogostemon cablin essential and step 3 obtain is uniformly mixed, and obtains compound essential oil；In compound essential oil, the quality of each component is matched
Than are as follows: the permanent flower essential oil of 20-25wt%, 10-15wt% olibanum essential oil, 20-25wt% Lavender, 5-10wt% tea tree essence
Oil, 1-3wt% Pogostemon cablin essential and 44-22wt% base oil.
The beneficial effects of the present invention are: the present invention provides a kind of preparation method of compound essential oil, this method process stabilizing,
Yield is high, quality is good, low energy consumption.Essential oil provided by the invention selects the plants essential oil extract composition containing active skull cap components
It forms, prescription proportion science does not add any artificial synthesis group point.Through human body and animal Efficacy experiments, toxicological test and metabolism
Experimental study shows the essential oil being prepared using method provided by the invention, and safe without toxic side effect absorbs fastly, and has
Significantly inhibit the effect of connective tissue formation, adjusting oil-water balance etc. are alleviated or treat scar.Essential oil provided by the invention uses
It is convenient, it is applied directly to skin area, massage absorbs, that is, can reach excellent curative effect.
Specific embodiment
The embodiment of technical solution of the present invention will be described in detail below.Following embodiment is only used for clearer
Illustrate technical solution of the present invention, therefore be only used as example, and not intended to limit the protection scope of the present invention.
The present invention provides a kind of preparation method of compound essential oil, and raw material components include permanent flower essential oil by weight
20-25 parts by weight, olibanum essential oil 10-15 parts by weight, Lavender 20-25 parts by weight, tea tree ethereal oil 5-10 parts by weight, the wide leaves of pulse plants
Essential oil 1-3 parts by weight and base oil 44-22 parts by weight.
Compound essential oil of the invention can also be formulated by raw material components by directly buying above-mentioned plants essential oil,
Method can be prepared as follows to obtain: after permanent flower and olibanum essential oil are extracted using supercritical carbon dioxide, reusing molecule steaming
The method of evaporating is refined；Steam distillation is respectively adopted after tea tree, Pogostemon cablin, lavender are crushed to extract；By fructus rosae
Squeezing method extracts after crushing, and freezing and filtering, obtains base oil；The extraction of essential oil object is uniformly mixed with the base oil, is obtained
To compound essential oil.
It is illustrated With reference to embodiment:
Embodiment 1:
Take permanent 20 parts by weight of flower essential oil, 10 parts by weight of olibanum essential oil, 20 parts by weight of Lavender, 5 weight of tea tree ethereal oil
It measures part, 44 parts by weight of Pogostemon cablin essential 1-3 parts by weight and rose hip oil, is uniformly mixed to obtain the final product.
Embodiment 2:
Take permanent 25 parts by weight of flower essential oil, 15 parts by weight of olibanum essential oil, 25 parts by weight of Lavender, 10 weight of tea tree ethereal oil
It measures part, 22 parts by weight of 3 parts by weight of Pogostemon cablin essential and rose hip oil, is uniformly mixed to obtain the final product.
Embodiment 3:
Permanent flower, olibanum is taken to crush to be extracted after coarse granule using supercritical carbon dioxide respectively, temperature is 45 DEG C, pressure
Power is 13.70MPa, time 50min, flow velocity 25kg/h；Extract is passed through into molecular distillation, feeding temperature 40 respectively again
DEG C, sample introduction speed is 480mL/h, and one section of evaporating temperature is 110 DEG C, and dual circulation temperature is 60 DEG C, obtains permanent flower and olibanum essence
Oil；It is extracted after lavender, tea tree, Pogostemon cablin are crushed respectively using steam distillation, the steam distillation
Liquid-to-solid ratio is 5ml:1g, that is, the water being added is 5 times of plant sample weight ratio, and 100 degree of vapo(u)rizing temperature, distillation time is 5 small
When, obtain plants essential oil；Fructus rosae is crushed and is placed in squeezer for coarse granule, squeeze and filter obtains crude oil, and crude oil is again through molecule
Distillation, feeding temperature are 40 DEG C, and sample introduction speed is 480mL/h, and one section of evaporating temperature is 110 DEG C, and dual circulation temperature is 60 DEG C,
Two sections of distillates are collected, base oil is obtained；Above-mentioned extraction of essential oil object and basic oil extract are pressed into permanent 25 parts by weight of flower essential oil, cream
15 parts by weight of essential oil, 25 parts by weight of Lavender, 10 parts by weight of tea tree ethereal oil, 3 parts by weight of Pogostemon cablin essential and fructus rosae
Oily 22 parts by weight are uniformly mixed, and obtain compound essential oil.
Embodiment 4:
Anti-inflammatory experiment:
We induce RAW264.7 cell for lipopolysaccharides (LPS) using Griess method and ELISA method test compound essential oil
The effect that middle NO and TNF-α generate, to evaluate the anti-inflammatory activity of compound essential oil.By RAW264.7 cell recovery, it is suitable to be passaged to
Density and in good condition, cell piping and druming uniformly, count under microscope, adjustment cell density to 2 × 105/ml.By every 100 μ of hole
L i.e. 2 × 104/hole kind plate, are incubated for 18h by 37 DEG C, 5%CO2, after removing serum 6h, add each acute drug and LPS to stimulate (overall
It is 200 μ l), after 18h, 100 μ l supernatants are taken, after detecting NO with Griess method, supernatant is taken out and carries out TNF-α detection.Note
Record the absorbance value under each concentration, and according to formula inhibiting rate=(model group-dosing group)/(model group-control group) ×
100% calculates the inhibiting rate that each group generates NO and TNF-α, recycles IC50Software for calculation calculates the IC of case 1-350Value,
Compound essential oil in all embodiment 1-3 shows significant anti-inflammatory activity.
Irritant experiment:
2-3 millimeters of notch can be cut in experimental animal leg, about in the case where 10-14 days (or shorter time) takes wound
Paraffin section is done after tissue is fixed, observes the change of its form.Recurrence essential oil in embodiment 1-3 does not show irritation.
Observation of curative effect:
Scar scoring uses Vancouver scar scale (VSS), comprehensive in terms of color, thickness, vascular distribution and pliability 4
Close assessment.Total score is 15 points, and the higher expression scar that scores is more serious.Formulating clinical efficacy criterion according to document is recovery from illness:
In scar >=90% part flattens, softens, touching without rhabdion or strand streak, pain of itching disappears, and stops nothing after treatment 6 months
Recurrence；Effective: 60%~89% part softens, flattens in scar, and itching, it is substantially reduced to keenly feel, without multiple after stopping treatment 6 months
Hair；Effective: 20%~59% part softens, flattens in scar, and pain of itching mitigates, without recurrence after stopping treatment 6 months；Nothing
Effect: scar is unchanged, and symptom, which is not improved, even to be aggravated, and recurs in 6 months after stopping treatment.Total effective rate (%)=
(recovery from illness number of cases+effective number of cases)/total number of cases × 100%.Statistical analysis, metering money are carried out using 19.0 statistical software of SPSS
Material is indicated with x ± s, relatively uses paired t-test in group before and after treatment, and comparison among groups use independent samples t-test.Between enumeration data group
Compare using chi-square criterion.It is that difference has statistics with P < 0.05.
The pretherapy and post-treatment VSS appraisal result of 1: two group of patient of table (x ± s, point)
Note: compared with before same group for the treatment of, * P < 0.05；Compared with after control group treatment,ΔP < 0.05
2: two groups of Clinical efficacy comparisons of table
| Group | Scar number | It cures | It is effective | Effectively | In vain | Total effective rate [example (%)] |
| Control group | 47 | 10 | 22 | 9 | 6 | 32(68.08) |
| Embodiment 1 | 49 | 15 | 28 | 4 | 2 | 43(87.75)Δ |
| Embodiment 2 | 50 | 16 | 28 | 4 | 2 | 44(88.00)Δ |
| Embodiment 3 | 48 | 15 | 27 | 5 | 2 | 43(87.75)Δ |
Note: compared with the control group, Δ P < 0.05
As can be seen from Table 1 and Table 2, the compound essential oil in embodiment can effectively repair scar.
Above-described embodiment is used to illustrate the present invention, rather than limits the invention, in spirit of the invention and
In scope of protection of the claims, to any modifications and changes that the present invention makes, protection scope of the present invention is both fallen within.
Claims (4)
1. a kind of scar repairs compound essential oil characterized by comprising the permanent flower essential oil of 20-25wt%, 10-15wt% olibanum
Essential oil, 20-25wt% Lavender, 5-10wt% tea tree ethereal oil, 1-3wt% Pogostemon cablin essential and 22-44wt% base oil.
2. scar repairs compound essential oil according to claim 1 characterized by comprising the permanent flower essential oil of 20wt%,
10wt% olibanum essential oil, 20wt% Lavender, 5wt% tea tree ethereal oil, 1wt% Pogostemon cablin essential and 44wt% base oil.
3. scar repairs compound essential oil according to claim 1, which is characterized in that the base oil is rose hip oil.
4. a kind of preparation method of compound essential oil described in claim 1, which comprises the following steps:
(1) it after crushing permanent flower and olibanum respectively, is extracted using supercritical carbon dioxide, reuses molecularly distilled and carry out essence
System, obtains permanent flower essential oil and olibanum essential oil；The temperature that the supercritical carbon dioxide extracts is 45 DEG C -48 DEG C, and pressure is
13.70MPa-17.80MPa, time 50min-100min, the flow velocity of carbon dioxide are 25kg/h-35kg/h；The molecule steams
The feeding temperature for evaporating method is 40 DEG C -45 DEG C, and sample introduction speed is 480-530mL/h, and one section of evaporating temperature is 110 DEG C -115 DEG C, two
Section evaporating temperature is 60 DEG C -65 DEG C.
(2) extracted after crushing lavender, tea tree, Pogostemon cablin respectively using steam distillation, obtain Lavender,
Tea tree ethereal oil, Pogostemon cablin essential；The liquid-to-solid ratio of the steam distillation is 3-7ml:1g, and vapo(u)rizing temperature is 100 DEG C -120 DEG C,
Distillation time is 5-7 hours.
(3) fructus rosae crushing is placed in squeezer and is squeezed, crude oil is collected by filtration, is refined using molecularly distilled, obtains base
Plinth oil；The feeding temperature of the molecularly distilled is 40 DEG C -45 DEG C, and sample introduction speed is 480-530mL/h, and one section of evaporating temperature is
110 DEG C -115 DEG C, dual circulation temperature is 60 DEG C -65 DEG C.
(4) by the permanent flower essential oil that step 1 obtains and the Lavender that olibanum essential oil, step 2 obtain, tea tree ethereal oil, the wide leaves of pulse plants
The base oil that essential oil and step 3 obtain is uniformly mixed, and obtains compound essential oil；In compound essential oil, the quality proportioning of each component are as follows:
The permanent flower essential oil of 20-25wt%, 10-15wt% olibanum essential oil, 20-25wt% Lavender, 5-10wt% tea tree ethereal oil, 1-
3wt% Pogostemon cablin essential and 44-22wt% base oil.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111544476A (en) * | 2020-03-30 | 2020-08-18 | 徐捷 | Scar-removing essential oil and preparation method and application thereof |
| CN113230358A (en) * | 2021-05-27 | 2021-08-10 | 刘丰君 | Cis-15-tetracosenoic acid-containing composition and preparation method of oil agent thereof |
| CN116492385A (en) * | 2023-06-27 | 2023-07-28 | 江西瑞秀朗科技有限公司 | Compound essential oil for repairing skin and pharmaceutical composition containing compound essential oil |
| CN116870081A (en) * | 2023-07-17 | 2023-10-13 | 南方医科大学深圳医院 | Composition for preventing and treating radiotherapy and chemotherapy related skin mucosa injury and application thereof |
-
2019
- 2019-06-27 CN CN201910567091.XA patent/CN110179694A/en not_active Withdrawn
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111544476A (en) * | 2020-03-30 | 2020-08-18 | 徐捷 | Scar-removing essential oil and preparation method and application thereof |
| CN111544476B (en) * | 2020-03-30 | 2022-09-13 | 徐捷 | Scar-removing essential oil and preparation method and application thereof |
| CN113230358A (en) * | 2021-05-27 | 2021-08-10 | 刘丰君 | Cis-15-tetracosenoic acid-containing composition and preparation method of oil agent thereof |
| CN116492385A (en) * | 2023-06-27 | 2023-07-28 | 江西瑞秀朗科技有限公司 | Compound essential oil for repairing skin and pharmaceutical composition containing compound essential oil |
| CN116492385B (en) * | 2023-06-27 | 2023-09-19 | 江西瑞秀朗科技有限公司 | Compound essential oil for repairing skin and pharmaceutical composition containing compound essential oil |
| CN116870081A (en) * | 2023-07-17 | 2023-10-13 | 南方医科大学深圳医院 | Composition for preventing and treating radiotherapy and chemotherapy related skin mucosa injury and application thereof |
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Application publication date: 20190830 |