CN113081917A - Female care solution containing hemp leaf extract and preparation method thereof - Google Patents

Abstract

The invention belongs to the technical field of daily chemical industry, and particularly relates to a female care solution containing a hemp leaf extract and a preparation method thereof, wherein the female care solution comprises a phase A raw material and a phase B raw material, and the phase A raw material comprises the following components in parts by weight: water, glycerin, carboxymethyl chitosan aqueous solution, mixed aqueous solution of butanediol and radix Sophorae Flavescentis extract, saccharide isomer, sodium cocamidopropionate, cocamidopropyl betaine aqueous solution, and antiseptic; the phase B raw materials comprise: water, PEG-40 hydrogenated castor oil, perfume, hemp leaf extract, bergamot fruit oil, lavender oil, lactic acid and silver; the hemp leaf extract contained in the care solution and other raw materials act together, the synergy is realized, the formula is reasonable, and after the components are combined and matched, the female vulva can be effectively cleaned, the sterilization and bacteriostasis effects are realized, the itching is relieved, and the peculiar smell is removed; the health care and medicinal value of the hemp leaf extract is fully exerted, and a new direction is provided for the application of the hemp leaf extract.

Description

Female care solution containing hemp leaf extract and preparation method thereof

The technical field is as follows:

the invention belongs to the technical field of daily chemical industry, and particularly relates to a female care solution containing a hemp leaf extract and a preparation method thereof.

Background art:

the female private parts are affected by physiological, fertility, sanitary, clean, economic and cultural factors, and are very easy to cause various infections. It is shown by the relevant data that in adult women around the world, about 85% suffer from varying degrees of gynecological inflammation, of which 46% of patients have problems with recurrent attacks of the disease, and the target consumers present a tendency to be younger, with 53.9% of students having symptoms associated with vaginitis, of which bacterial vaginitis is predominant (35.9%), followed by candidal vaginitis (23.6%). Therefore, daily bacteriostasis and washing care are particularly important for reducing the occurrence of gynecological inflammation.

At present, a plurality of special care solutions with bacteriostatic and bactericidal functions for women are available in the market, for example, Chinese patent application CN111481597A discloses a herbal bacteriostatic care solution for women and a preparation method thereof, the care solution takes a composition of piroctone olamine, grapefruit oil, eucalyptus essential oil and cocoyl disodium glutamate as main bacteriostatic components, has a remarkable inhibitory effect on staphylococcus aureus and escherichia coli, particularly candida albicans, and is safe and non-irritant by being matched with a plant care agent with a highly natural plant source; chinese patent application CN108403520A discloses a chitosan Chinese herbal medicine female care solution, which consists of water-soluble chitosan, propylene glycol, traditional Chinese medicine extract, compound essential oil, emulsifier, chlorhexidine and purified water; the preparation method comprises the steps of preparing a traditional Chinese medicine extracting solution, preparing compound essential oil and preparing a care solution; is mild and non-irritant, and can effectively clean female vulva, sterilize and inhibit bacteria, relieve itching, remove peculiar smell and prevent pudendum inflammation.

Industrial hemp refers to hemp having a tetrahydrocannabinol content of less than 0.3%, which is called hemp (hemp) in china, is an annual herb plant of Cannabis (Cannabiaceae) in Cannabis, which is classified into industrial hemp and drug hemp, and is widely used at home and abroad. The industrial hemp which is allowed to be legally planted is a variety with low toxicity, and the THC value is lower than 0.3 percent. These industrial hemp (THC < 0.3%) are considered to have no drug utility, but still are useful in the whole body, and their applications include at least fields of textile, paper, food, medicine, hygiene, daily chemicals, leather, automobile, construction, decoration, packaging, and the like. Is a classical production material. The content of CBD in the hemp leaf extract of industrial hemp is high, the CBD is proved to have anti-inflammatory and antioxidant activity, can regulate cell cycle and immune cell function and can inhibit the production of various proinflammatory cytokines, but the utilization value of the CBD is not fully developed, and the research report of applying the hemp leaf extract to a female care solution does not appear at present.

The invention content is as follows:

in order to overcome the defects in the prior art, the invention provides a female care solution containing a hemp leaf extract and a preparation method thereof.

In order to achieve the purpose, the invention provides a female care solution containing a hemp leaf extract, which comprises the following raw materials in parts by weight: 45-60 parts of water, 1-5 parts of glycerol, 0.1-0.5 part of carboxymethyl chitosan aqueous solution, 0.1-0.5 part of mixed aqueous solution of butanediol and sophora flavescens extract, 1-5 parts of saccharide isomer, 1-10 parts of sodium cocoamidopropionate, 5-20 parts of cocamidopropyl betaine aqueous solution and 0.1-1 part of preservative;

the phase B raw materials comprise the following components in parts by weight: 20-30 parts of water, 0.1-1 part of PEG-40 hydrogenated castor oil, 0.01-0.05 part of aromatic, 0.01-0.5 part of hemp leaf extract, 0.01-0.05 part of bergamot fruit oil, 0.1-0.5 part of lavender oil, 0.01-0.05 part of lactic acid and 0.02-0.2 part of silver.

Further, in the phase A raw material, the mass ratio of butanediol to the sophora flavescens extract to water in a mixed aqueous solution of butanediol and the sophora flavescens extract is 1-2: 2-5: 5-13; the mass percent of the carboxymethyl chitosan in the carboxymethyl chitosan aqueous solution is 88 percent; the mass percentage of cocamidopropyl betaine in the aqueous solution of cocamidopropyl betaine was 30%.

Furthermore, in the phase B raw material, the preservative is a mixture of propylene glycol, phenoxyethanol, 1, 2-hexanediol and caprylyl hydroximic acid in a mass ratio of 15-21: 8-10: 5-7: 3-6, and the aromatic is a mixture of propylene glycol, phenoxyethanol, 1, 2-hexanediol and caprylyl hydroximic acid in a mass ratio of 1-2: 1-3 of a mixture of menthol lactate and menthoxypropanediol.

Further, the content of CBD in the cannabis leaf extract is 30-60%.

The invention also provides a preparation method of the female care solution containing the hemp leaf extract, which comprises the following specific steps:

(1) accurately weighing the phase A raw materials, sequentially putting the phase A raw materials into a clean and disinfected stirring pot, starting stirring, and stirring for 3-5 minutes at normal temperature;

(2) accurately weighing each raw material of the B phase, firstly putting water of the raw material of the B phase into a stirring pot, then sequentially dispersing and dissolving an aromatic agent, a hemp leaf extract, bergamot fruit oil and lavender oil of the raw material of the B phase into PEG-40 hydrogenated castor oil, then adding into the stirring pot, uniformly stirring, standing for defoaming, then adding lactic acid to adjust the pH value to 6.3-6.5, finally adding silver, uniformly stirring until the care solution is a transparent solution, discharging after the detection is qualified, and thus obtaining the female care solution containing the hemp leaf extract.

Compared with the prior art, the hemp leaf extract contained in the care solution disclosed by the invention and other raw materials act together, so that the synergistic effect is realized, the formula is reasonable, and after the components are combined and matched, the care solution can effectively clean female vulva, sterilize and inhibit bacteria, relieve itching, remove peculiar smell, prevent pudendum inflammation and provide long-acting protection for female pudendum; the care solution can fully exert the health care and medicinal values of the hemp leaf extract, expand the female care solution market and assist female health; meanwhile, a new direction is provided for the application of the hemp leaf extract.

The specific implementation mode is as follows:

the invention is further illustrated by the following specific examples.

Example 1:

the embodiment relates to a female care solution containing a hemp leaf extract, which comprises the following raw materials in parts by weight:

phase A: 50 parts of water, 3 parts of glycerol, 0.1 part of 88 mass percent carboxymethyl chitosan aqueous solution, 0.3 part of mixed aqueous solution of butanediol and a sophora flavescens extract, 1 part of saccharide isomer, 5 parts of sodium cocoamidopropionate, 10 parts of 30 mass percent cocamidopropyl betaine aqueous solution and 0.4 part of preservative;

phase B: 28.15 parts of water, 0.6 part of PEG-40 hydrogenated castor oil, 0.05 part of aromatic, 0.01 part of hemp leaf extract, 0.02 part of bergamot fruit oil, 0.2 part of lavender oil, 0.04 part of lactic acid and 0.13 part of silver;

wherein the mixed aqueous solution of butanediol and radix Sophorae Flavescentis extract is butanediol: and (3) sophora flavescens extract: a mixed aqueous solution with a water mass ratio of 2:3: 5; the preservative is a mixture of propylene glycol, phenoxyethanol, 1, 2-hexanediol and caprylyl hydroximic acid in a mass ratio of 21:10:5: 4; the mass ratio of the aromatic is 1:1 and menthoxypropanediol.

The hemp leaf extract is derived from legally planted industrial hemp, the CBD content of the hemp leaf extract is 30-60%, and the specific preparation steps are as follows:

(1) pretreatment of raw materials: sieving the dried industrial hemp flowers and leaves by using a vibrating screen, removing hemp seeds, hemp stalks and sandstone impurities, and crushing by using a crusher to 10-30 meshes to obtain a primary raw material of the industrial hemp flowers and leaves;

(2) drying treatment of raw materials: drying the primary raw material obtained in the step (1) for 0.5-3 h by using hot air belt type drying equipment to obtain a dry industrial hemp flower leaf raw material with the moisture of less than 7%;

(3) ethanol extraction: and (3) performing ethanol solvent extraction on the dried flower and leaf raw material obtained in the step (2) in a multifunctional extraction tank, wherein the mass ratio of ethanol to the flower and leaf raw material is 6: 1, obtaining primary extracting solution and residue; the residue was measured as 4: 1, extracting with secondary ethanol to obtain a secondary extracting solution and waste residues; the residue was prepared as follows: 1, carrying out third ethanol extraction to obtain third extracting solution and waste residue; mixing the three extracting solutions to obtain CBD extracting solution;

(4) concentration: carrying out vacuum reduced pressure concentration on the extract liquid obtained in the step (3) to obtain a concentrated solution;

(5) ultra-low temperature degreasing and dewaxing: according to the proportion of the concentrated solution to 95% (vol) food grade ethanol of 1: 5(w/w), uniformly mixing, carrying out ultralow-temperature freeze degreasing and dewaxing for 3-8 h, carrying out centrifugal separation, and filtering to obtain a primary treatment solution;

(6) and (3) decoloring: performing combined decolorization on the primary treatment liquid for 30-60 min by using activated carbon and macromolecular resin, wherein the sample loading amount during decolorization is 5-10%, and filtering and separating to obtain secondary treatment liquid; concentrating the secondary treatment liquid to obtain an intermediate product CBD concentrated crude oil;

(7) molecular distillation: performing short-range molecular distillation on the CBD concentrated crude oil obtained in the step (6) at the temperature of 90-170 ℃, and fully decarboxylating and converting CBDA in the crude oil into CBD to obtain CBD full spectrum oil with the CBD content of 25-35%;

(8) industrial preparative chromatographic separation and purification: conveying the CBD full spectrum oil of the step (7) to a sample tank, and performing oil extraction on the CBD full spectrum oil by using a pressure ratio of 1:1, then loading the sample on a high-pressure chromatographic column with the sample loading amount of 30-50 mgCBD/mL, and adopting 50-85% ethanol solution (vol) as an analytical eluent under the pressure of 20-40 bar; performing accurate separation by an industrial preparation high performance liquid chromatography system, firstly balancing with 40-60% ethanol solution, eluting with 50-85% ethanol solution for 5-10 times of column volume, then eluting with 50-85% ethanol solution for 5-10 times of column volume to elute target components, and collecting eluent rich in the target components to obtain CBD component enrichment solution;

accurately cutting the enriched liquid of the foreimpurity and CBD components into different storage tanks according to the CBD map in the eluent;

(9) and (3) vacuum concentration: and (4) carrying out vacuum reduced pressure concentration on the CBD component liquid obtained in the step (8) to obtain the cannabis leaf extract with the CBD content of 30-60%.

The butanediol, the sophora flavescens extract and the silver are used as bactericides, and the butanediol, the sophora flavescens extract and the silver are synergistic, so that staphylococcus aureus and escherichia coli can be effectively killed.

The lavender oil, bergamot fruit oil and hemp leaf extract are used as skin conditioners, can reduce stimulation to vaginal mucosa, and play a role in protecting female vaginal mucosa in the using process. The content of CBD in the hemp leaf extract is 30-60%, and the CBD has been proved to have anti-inflammatory and antioxidant activities, can regulate cell cycle and immune cell functions, can inhibit the production of various proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1 beta and the like, and can also inhibit the proliferation, activation, maturation, migration and antigen presentation of immune cells. Therefore, the hemp leaves extracted from the Chinese magnoliavine have good treatment potential in the aspect of inflammatory skin diseases.

The carboxymethyl chitosan is used as an antiallergic agent and plays a role in preventing allergy in the using process.

The glycerin and saccharide isomerate is used as a humectant and plays a role in preventing skin dryness in the using process.

The sodium cocamidopropionate and cocamidopropyl betaine act as surfactants, which act as a foaming agent during use.

The PEG-40 hydrogenated castor oil is used as solubilizer for dispersing and dissolving the aromatic, the hemp leaf extract, the bergamot fruit oil and the lavender oil, so that the final care solution is transparent.

The aromatic adopts menthol lactate and menthoxypropanediol, can adjust the smell of the care solution, and also has very good cooling effect.

The preservative is used for preventing the care solution from being rotten and deteriorated, and the dosage of the preservative is harmless to human bodies.

The lactic acid is used for adjusting the pH value of the care solution.

The preparation method of the female care solution containing the cannabis sativa leaf extract, which is disclosed by the embodiment, comprises the following specific steps of:

(1) accurately weighing the phase A raw materials, sequentially putting the phase A raw materials into a clean and disinfected stirring pot, starting stirring, and stirring for 3-5 minutes at normal temperature;

(2) putting weighed water of the B-phase raw material into a stirring pot, sequentially dispersing and dissolving an aromatic agent, a hemp leaf extract, bergamot fruit oil and lavender oil of the B-phase raw material into PEG-40 hydrogenated castor oil, adding into the stirring pot, uniformly stirring, standing for defoaming, adding lactic acid to adjust the pH value to 6.3-6.5, finally adding silver, uniformly stirring until the care solution is a transparent solution, and discharging after the detection is qualified to obtain the female care solution containing the hemp leaf extract.

Example 2:

the embodiment of the invention relates to a female care solution containing a hemp leaf extract, which comprises the following raw materials in parts by weight:

phase A: 54.78 parts of water, 5 parts of glycerol, 0.5 part of 88 mass percent carboxymethyl chitosan aqueous solution, 0.2 part of mixed aqueous solution of butanediol and sophora flavescens extracts, 1.5 parts of saccharide isomers, 2 parts of sodium cocoamidopropionate, 5 parts of 30 mass percent cocamidopropyl betaine aqueous solution and 0.1 part of preservative;

phase B: 30 parts of water, 0.2 part of PEG-40 hydrogenated castor oil, 0.02 part of aromatic, 0.1 part of hemp leaf extract, 0.1 part of bergamot fruit oil, 0.3 part of lavender oil, 0.1 part of lactic acid and 0.1 part of silver;

wherein the mixed aqueous solution of butanediol and radix Sophorae Flavescentis extract is butanediol: and (3) sophora flavescens extract: a mixed aqueous solution with a water mass ratio of 2:5: 13; the preservative is a mixture of propylene glycol, phenoxyethanol, 1, 2-hexanediol and caprylyl hydroximic acid in a mass ratio of 15:8:7: 6; the mass ratio of the aromatic is 2:3 and menthoxypropanediol.

Example 3:

the embodiment of the invention relates to a female care solution containing a hemp leaf extract, which comprises the following raw materials in parts by weight:

phase A: 57.89 parts of water, 1 part of glycerol, 0.5 part of 88 mass percent carboxymethyl chitosan aqueous solution, 0.5 part of mixed aqueous solution of butanediol and sophora flavescens extracts, 3 parts of saccharide isomers, 1 part of sodium cocoamidopropionate, 8 parts of 30 mass percent cocoamidopropyl betaine aqueous solution and 0.8 part of preservative;

phase B: 25 parts of water, 1 part of PEG-40 hydrogenated castor oil, 0.05 part of aromatic, 0.5 part of hemp leaf extract, 0.05 part of bergamot fruit oil, 0.5 part of lavender oil, 0.01 part of lactic acid and 0.2 part of silver;

wherein the mixed aqueous solution of butanediol and radix Sophorae Flavescentis extract is butanediol: and (3) sophora flavescens extract: a mixed aqueous solution with a water mass ratio of 1:2: 7; the preservative is a mixture of propylene glycol, phenoxyethanol, 1, 2-hexanediol and caprylyl hydroximic acid in a mass ratio of 21:8:5: 3; the mass ratio of the aromatic is 2: 1 and menthoxypropanediol.

Example 4:

this example is a test of the bacteriostatic effect of the female care solution containing the hemp leaf extract of examples 1-3. The results are shown in Table 1.

TABLE 1 bacteriostatic rate of nursing liquid at different time

As can be seen from Table 1, the care solution provided by the invention can effectively inhibit staphylococcus aureus and escherichia coli, and the care solution is proved to be suitable for vast women and is used as a female health assistance.

Claims (5)

1. A female care solution containing hemp leaf extract is characterized in that the raw materials comprise an A phase raw material and a B phase raw material, and the raw materials comprise the following components in parts by weight: phase A: 45-60 parts of water, 1-5 parts of glycerol, 0.1-0.5 part of carboxymethyl chitosan aqueous solution, 0.1-0.5 part of mixed aqueous solution of butanediol and sophora flavescens extract, 1-5 parts of saccharide isomer, 1-10 parts of sodium cocoamidopropionate, 5-20 parts of cocamidopropyl betaine aqueous solution and 0.1-1 part of preservative;

phase B: 20-30 parts of water, 0.1-1 part of PEG-40 hydrogenated castor oil, 0.01-0.05 part of aromatic, 0.01-0.5 part of hemp leaf extract, 0.01-0.05 part of bergamot fruit oil, 0.1-0.5 part of lavender oil, 0.01-0.05 part of lactic acid and 0.02-0.2 part of silver.

2. The female care solution containing cannabis leaf extract as claimed in claim 1, characterized in that, in the phase A raw material, the mass ratio of the butanediol, the radix sophorae flavescentis extract and water in the mixed aqueous solution of the butanediol and the radix sophorae flavescentis extract is 1-2: 2-5: 5-13; the mass percent of the carboxymethyl chitosan in the carboxymethyl chitosan aqueous solution is 88 percent; the mass percentage of cocamidopropyl betaine in the aqueous solution of cocamidopropyl betaine was 30%.

3. The female care solution containing cannabis leaf extract as claimed in claim 1, characterized in that in the phase B raw materials, the preservative is 15-21: 8-10: 5-7: 3-6 of propylene glycol, phenoxyethanol, 1, 2-hexanediol and caprylyl hydroximic acid, wherein the mass ratio of the aromatic is (1-2): 1-3 of a mixture of menthol lactate and menthoxypropanediol.

4. The female care solution containing cannabis leaf extract as claimed in claim 1, characterized in that the content of CBD in the cannabis leaf extract is 30-60%.

5. The female care solution containing cannabis leaf extract as claimed in claim 1, characterized in that the preparation method thereof comprises the specific steps of:

(1) accurately weighing the phase A raw materials, sequentially putting the phase A raw materials into a clean and disinfected stirring pot, starting stirring, and stirring for 3-5 minutes at normal temperature;

(2) accurately weighing each raw material of the B phase, firstly putting water of the raw material of the B phase into a stirring pot, then sequentially dispersing and dissolving an aromatic agent, a hemp leaf extract, bergamot fruit oil and lavender oil of the raw material of the B phase into PEG-40 hydrogenated castor oil, then adding into the stirring pot, uniformly stirring, standing for defoaming, then adding lactic acid to adjust the pH value to 6.3-6.5, finally adding silver, uniformly stirring until the care solution is a transparent solution, discharging after the detection is qualified, and thus obtaining the female care solution containing the hemp leaf extract.