CN111388572A - Compound essential oil and preparation method, preparation and application thereof - Google Patents
Compound essential oil and preparation method, preparation and application thereof Download PDFInfo
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Abstract
The invention relates to the field of medicines, and particularly discloses compound essential oil, a preparation method, a preparation and an application thereof, wherein the compound essential oil comprises the following raw materials: valerian latifolia essential oil, lavender essential oil and a solvent; wherein the volume ratio of the valerian latifolia essential oil to the lavender essential oil is 1-9: 9-1. The compound essential oil prepared by the invention has excellent effects of calming and helping sleep, the peculiar taste of valerian latifolia is improved through reasonable compatibility of valerian latifolia essential oil and lavender essential oil, the curative effect is synergistically improved, and the compound essential oil acts on the central nervous system through olfactory pathways to play a role of calming and helping sleep. Moreover, because the aromatic inhalation therapy is adopted, compared with oral drugs, the aromatic inhalation therapy has strong safety, can avoid the hangover in the daytime, eliminate the first-pass effect and stimulate the gastrointestinal tract; the preparation method provided by the invention is simple, the raw materials are easy to obtain, the preparation method is suitable for industrial production, and the problem that most of the existing medicines for treating insomnia need to be orally taken and have low safety is solved.
Description
Technical Field
The invention relates to the field of medicines, in particular to compound essential oil, and a preparation method, a preparation and application thereof.
Background
With the continuous development of society, the sleep problems of people in modern society become more common, and about 30 kinds of sleep disorders are proposed so far, and insomnia is one of the most common sleep disorders. Because the sleep has important significance for maintaining physiological and psychological health, the life and work of people can be influenced by long-term insomnia, the risk of suffering from various diseases is increased, and the body health is influenced.
At present, the drugs for clinically treating insomnia mainly comprise benzodiazepine receptor agonists, melatonin receptor agonists, orexin receptor antagonists and antidepressant drugs with hypnotic effect. Although the treatment methods are quite many, most of the medicines are oral medicines, have certain toxic and side effects, and easily stimulate the gastrointestinal tract.
Moreover, the above technical solution has the following disadvantages in practical use: the existing medicines for treating insomnia are mostly western medicines, are mostly required to be orally taken, have low safety, and may have adverse reactions such as daytime sleepiness, withdrawal symptoms, rebound insomnia and the like after long-term use.
Disclosure of Invention
The embodiment of the invention aims to provide compound essential oil and a preparation method, a preparation and application thereof, so as to solve the problems that most of the existing medicines for treating insomnia in the background art need to be orally taken and have low safety.
In order to achieve the purpose, the invention provides the following technical scheme:
a compound essential oil comprises the following raw materials: valerian latifolia essential oil, lavender essential oil and a proper amount of solvent; wherein the volume ratio of the valerian latifolia essential oil to the lavender essential oil is 1-9: 9-1.
As a further scheme of the invention: the volume ratio of the valerian latifolia essential oil to the lavender essential oil is 4-7: 5-3.
As a further scheme of the invention: the solvent is selected from one or more of water, ethanol or glycerol. For example, ethanol may be used alone, or an aqueous solution of ethanol with a mass concentration of 70% to 80%, which is specifically selected according to the requirement, and is not limited herein.
As a further scheme of the invention: the dosage of the solvent is 5-10 times of the volume sum of the valerian latifolia essential oil and the lavender essential oil.
As a still further scheme of the invention: the solvent is selected from dideal alcohol. Specifically, commercially available dideal alcohols can be used for preparing perfumes.
Preferably, the volume ratio of the valerian latifolia essential oil, the lavender essential oil and the dideal alcohol in the compound essential oil is 7:3: 90.
As a still further scheme of the invention: the water may be any one selected from purified water, mineral water, distilled water, deionized water, and soft water, and is not limited thereto and may be selected as needed.
As a still further scheme of the invention: the Valeriana officinalis L.oil is purchased from Guiyang Zhi spice factory, and can be other Valeriana officinalis L.oil (C.A.)Valeriana officinalisLinn.var. latifoliaMiq.) The valerian latifolia essential oil extracted by steam distillation is selected according to the requirements, and is not limited herein.
As a still further scheme of the invention: the lavender essential oil is lavender angustifolia essential oil purchased from natural plant limited company in Ji' an, of course, other commercially available lavandula angustifolia essential oils extracted by a steam distillation method can be used, and the lavender essential oil is selected according to the requirements, and is not limited herein.
Another objective of the embodiments of the present invention is to provide a method for preparing a compound essential oil, which comprises the following steps:
1) weighing valerian latifolia essential oil and lavender essential oil according to a proportion, mixing uniformly, gradually adding a solvent, stirring and mixing to obtain a mixture;
2) aging the mixture obtained in the step 1) in a cold and dark place to obtain the compound essential oil.
As a still further scheme of the invention: the aging can be carried out for 40-50 hours at 8-15 ℃ in the dark.
The embodiment of the invention also aims to provide the compound essential oil prepared by the preparation method.
As a still further scheme of the invention: the compound essential oil is applied to the preparation of the medicine for treating insomnia.
Another object of the embodiments of the present invention is to provide a preparation, which comprises part or all of the above compound essential oil.
As a still further scheme of the invention: the preparation method of the preparation comprises the following steps: filling the compound essential oil into a container, and sealing to obtain the preparation. Specifically, the composition can be filled into a ball container to prepare a sleep-aiding rod, or can be filled into a spray bottle or sealed in a sealed bag to prepare a preparation, and the composition is designed according to requirements and is not limited herein.
Another object of the embodiments of the present invention is to provide a use of the above-mentioned preparation in the preparation of a medicament for treating insomnia.
As a still further scheme of the invention: in the application of the preparation, the preparation has the effects of calming and helping sleep, and can relieve mild insomnia or assist other insomnia treatment medicines to be used for treating severe insomnia.
As a still further scheme of the invention: in the application of the preparation, the use method of the preparation is as follows: according to the aromatic inhalation therapy, the preparation is applied under the nose, or is placed under the nose by a container, the specific mode is selected according to the requirement, and the preparation is not limited in the specification, and the preparation can be inhaled into the nasal cavity and acts on the central nervous system through an olfactory pathway to achieve the effects of calming and helping sleep. Of course, the preparation can also be applied to the places with thin skin and good transdermal absorption effect, such as the back of the ear, the inner side of the lower arm and the like, and the preparation can quickly enter blood to play a role in calming and helping sleep.
Compared with the prior art, the invention has the beneficial effects that:
the compound essential oil prepared by the embodiment of the invention has excellent sedative sleep-aiding effect, can be inhaled into nasal cavity by adopting aromatic inhalation therapy, and acts on central nervous system by olfactory pathway through reasonable compatibility of valerian latifolia essential oil and lavender essential oil, thus playing the sedative sleep-aiding effect; moreover, the aromatic inhalation therapy is adopted, so that mild insomnia can be relieved or other medicines can be assisted to treat severe insomnia, compared with oral medicines, the safety is high, the daily hangover can be avoided, the first-pass effect can be eliminated, and gastrointestinal tract irritation can be avoided; the compound essential oil provided by the invention is simple in preparation method, easy in raw material obtaining and suitable for industrial production, the sedative and sleep-aiding effects of valerian latifolia by inhalation administration are verified for the first time, the peculiar taste of valerian latifolia is improved through reasonable compatibility of valerian latifolia essential oil and lavender essential oil, the curative effect is synergistically improved, the problem of low safety caused by the fact that most of the existing medicines for treating insomnia need to be orally taken, adverse reactions such as daytime sleepiness, withdrawal symptoms, rebound insomnia and the like can occur due to long-term use is solved, and meanwhile, the further development and utilization of domestic valerian latifolia can be promoted, and the compound essential oil has a wide market prospect.
Detailed Description
The present invention will be described in further detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications can be made by persons skilled in the art without departing from the spirit of the invention. All falling within the scope of the present invention.
Example 1
A compound essential oil comprises the following raw materials: 9 liters of valerian latifolia essential oil, 1 liter of lavender essential oil and 90 liters of dideal alcohol.
In the embodiment of the invention, the preparation method of the compound essential oil comprises the following steps:
1) weighing Valeriana officinalis L.oil and Lavender oil, mixing, gradually adding dialdehyde ethanol, stirring, and mixing to obtain mixture;
2) aging the mixture obtained in the step 1) in a cold and dark place to obtain the compound essential oil, wherein the aging is carried out for 48 hours in a dark place at the temperature of 10 ℃.
Example 2
The procedure of example 1 was repeated except that the amount of valerian latifolia essential oil was 7 liters and the amount of lavender essential oil was 3 liters, as compared with example 1.
Example 3
The procedure of example 1 was repeated except that the amount of valerian latifolia essential oil was 5 liters and the amount of lavender essential oil was 5 liters, as compared with example 1.
Example 4
The procedure was as in example 1 except that the amount of valerian latifolia essential oil was 3 liters and the amount of lavender essential oil was 7 liters, as compared with example 1.
Example 5
The procedure was as in example 1 except that the amount of valerian latifolia essential oil was 1 liter and the amount of lavender essential oil was 9 liters as compared with example 1.
Example 6
A compound essential oil comprises the following raw materials: 3 liters of valerian latifolia essential oil, 7 liters of lavender essential oil and 100 liters of dideal alcohol.
In the embodiment of the invention, the preparation method of the compound essential oil comprises the following steps:
1) weighing Valeriana officinalis L.oil and Lavender oil, mixing, gradually adding dialdehyde ethanol, stirring, and mixing to obtain mixture;
2) aging the mixture obtained in the step 1) in a cold and dark place to obtain the compound essential oil, wherein the aging is carried out for 40 hours in a dark place at the temperature of 8 ℃.
Example 7
The same procedure as in example 6 was repeated, except that the aging was carried out at 15 ℃ for 50 hours in the absence of light.
Example 8
Same as example 6 except that the alcohol was 50 liters, compared with example 6.
Example 9
The same as example 6 except that the alcohol obtained by removing aldehyde in the above-mentioned reaction mixture was replaced with water, as compared with example 6.
Example 10
The same as example 6 except that the alcohol obtained by removing aldehyde in the above-mentioned reaction mixture was replaced with 70% by mass of an aqueous ethanol solution as compared with example 6.
Example 11
The compound essential oil in the examples 1 to 5 is subjected to a sedation and sleep-aiding efficacy verification experiment, and the specific method is as follows:
1) animal grouping: selecting 90 Kunming mice, each half of which is female and male, randomly grouping, and 10 mice in each group; during the experiment, the mice can obtain enough food and water, the light and the shade of the experiment environment are alternated for 12h, the mice can drink water and eat food freely, and the experiment is started after 1 week of adaptive feeding; wherein, the experiment is provided with a blank group, a positive medicine group, a valerian latifolia group, a lavender group and a compound essential oil group, and the compound essential oil group is respectively used for the experiment by using the compound essential oil in the embodiments 1-5;
2) the administration comprises administering the above medicinal materials, specifically, 0.1 m L/10 g of intragastric drinking water, and 0.200 m 0.200 × 10g of liquid transfer gun-3m L the compound essential oil prepared in one of the embodiments 1-5 is dropped on a 5 × 5cm piece of filter paper, two pieces of filter paper dropped with the compound essential oil are placed in an aroma chamber, one mouse is placed in each aroma chamber, a glass plate is covered, aroma is carried out for 30 min, a camera is used for shooting and video naming, the time period for inhaling and smelling each group is fixed to be 13:00-17:00 per day in order to prevent the influence of circadian rhythm, the blank group is a drinking water filled with 0.1 m L/10 g of stomach, 0.2 m L of olive oil is respectively dropped on the two pieces of filter paper in the aroma chamber, the other operations are the same as those of the compound essential oil group, the positive medicine group is a 0.1 m L/10 g of stomach filled with 0.25 mg/m L of estazolam solution, the other operations are the same as those of the blank group, the valerian oil group is prepared by replacing the compound essential oil in the compound essential oil group with the lavender essential oil, and the other compound essential oil is the same as the compound essential oil group;
3) and (3) testing the autonomous activity of the mouse: placing the mice subjected to drug administration in the blank group, the positive drug group, the valerian latifolia group, the lavender group and the compound essential oil group into a fragrance chamber cover to start watching a video, and counting the longitudinal line crossing times and the standing and wall supporting times of each mouse within half an hour after the filter paper is placed and the cover is covered, wherein the specific longitudinal line crossing times and the standing and wall supporting times are respectively shown in tables 1 and 2;
4) and (3) testing the sleep-onset rate induced by the pentobarbital sodium, namely after each group of mice are subjected to aromatherapy for 0.5 h, respectively carrying out intraperitoneal injection on the pentobarbital sodium with the maximum subthreshold dose of 0.1 m L/10 g, counting the number of mice falling asleep by taking the mice turn-over reflex disappearance of more than or equal to 1 min after administration as an index of falling asleep, and calculating the sleep-onset rate of the mice, wherein the specific result of the sleep-onset rate of the mice is shown in Table 3.
TABLE 1 results of number of times of crossing longitudinal lines
| Group of | Number of animals | Number of crossing the longitudinal line | Rate of change (%) |
| Blank group | 10 | 486.2±137.3 | - |
| Positive drug group | 10 | 123.7±115.3 | -74.6 |
| Lavender essential oil | 10 | 481.8±159.3 | -0.9 |
| Valeriana officinalis essential oil | 10 | 424.8±122.6 | -12.6 |
| Example 1 | 10 | 411.6±148.4 | -15.3 |
| Example 2 | 10 | 283.6±91.6 | -41.7 |
| Example 3 | 10 | 612.6±524.2 | 26.0 |
| Example 4 | 10 | 365.2±96.8 | -24.9 |
| Example 5 | 10 | 432.3±200.8 | -11.1 |
TABLE 2 standing buttress times results table
| Group of | Number of animals | Number of times of standing and supporting wall | Rate of change (%) |
| Blank group | 10 | 177.4±65.1 | 0 |
| Positive drug group | 10 | 29.2±31.8 | -83.5 |
| Lavender essential oil | 10 | 179.2±48.0 | 1.0 |
| Valeriana officinalis essential oil | 10 | 150.5±24.6 | -15.2 |
| Example 1 | 10 | 120.9±26.9 | -31.8 |
| Example 2 | 10 | 93.3±14.8 | -47.4 |
| Example 3 | 10 | 147.5±99.1 | -16.9 |
| Example 4 | 10 | 95.3±26.2 | -46.3 |
| Example 5 | 10 | 129.2±49.2 | -27.2 |
TABLE 3 results of the rate of onset of sleep in mice
| Group of | Number of animals | Sleep onset Rate (%) |
| Blank group | 10 | 0 |
| Positive drug group | 10 | 50 |
| Lavender essential oil | 10 | 0 |
| Valeriana officinalis essential oil | 10 | 0 |
| Example 1 | 10 | 0 |
| Example 2 | 10 | 0 |
| Example 3 | 10 | 40 |
| Example 4 | 10 | 20 |
| Example 5 | 10 | 30 |
From the data in tables 1-3, the more the number of vertical line crossing times and the more the number of standing wall supporting times represent the stronger the self-activity of the mouse, and the drug with the sedative effect can reduce the activity of the mouse, which is represented by the reduction of the number of vertical line crossing times and the reduction of the number of standing wall supporting times. The longitudinal line crossing times and standing and wall supporting times of the compound essential oil are generally less than those of the lavender essential oil or the valerian latifolia essential oil which is independently adopted, and the sedative effect of the compound essential oil prepared in the embodiment of the invention is proved to be better than that of the lavender essential oil or the valerian latifolia essential oil which is independently adopted.
Example 12
The compound essential oils prepared in examples 1 to 5 were scored on volunteers by adding ten milliliters each of the compound essential oils prepared in examples 1 to 5 into a 10 m L centrifuge tube, selecting volunteers who smell with test paper and can remember and distinguish the tastes of peppermint essential oil, tenfold diluted peppermint essential oil, one hundred fold diluted peppermint oil and vetiver essential oil, and after smelling coffee, the volunteers dip the five compound essential oils prepared in examples 1 to 5 with the test paper, and after smelling, the five compound essential oils were scored according to the fragrance (full score of 10), and the specific fragrance scoring results are shown in table 4.
TABLE 4 fragrance scoring results table
| Serial number | Sex | Age (age) | Example 1 | Example 2 | Example 3 | Example 4 | Example 5 |
| 1 | Woman | 19 | 5.5 | 6 | 7 | 6 | 6 |
| 2 | Woman | 19 | 5 | 4 | 4 | 3 | 6 |
| 3 | Woman | 19 | 8 | 9 | 7 | 6 | 6 |
| 4 | Woman | 20 | 5 | 7 | 2 | 1 | 3 |
| 5 | Woman | 18 | 2 | 7 | 5 | 6 | 6 |
| 6 | Woman | 19 | 4 | 6 | 6 | 5 | 8 |
| 7 | Woman | 18 | 3 | 3 | 3 | 3 | 3 |
| 8 | Woman | 18 | 5 | 8 | 7 | 5 | 7 |
| 9 | Woman | 19 | 10 | 9 | 7 | 8 | 8 |
| 10 | Woman | 19 | 8 | 8 | 7 | 8 | 9 |
| 11 | Woman | 19 | 4 | 3 | 2 | 4 | 5 |
| 12 | Woman | 19 | 6 | 4 | 5 | 3 | 4 |
| 13 | Woman | 21 | 8 | 4 | 9 | 8 | 9 |
| 14 | For male | 19 | 7 | 5 | 7 | 5 | 6 |
The average values were calculated based on the data in table 4, wherein the average value of the fragrance score of the compound essential oil prepared in example 1 was 5.28, the average value of the fragrance score of the compound essential oil prepared in example 2 was 6.56, the average value of the fragrance score of the compound essential oil prepared in example 3 was 5.33, the average value of the fragrance score of the compound essential oil prepared in example 4 was 4.78, and the average value of the fragrance score of the compound essential oil prepared in example 5 was 5.89, and as can be seen from table 4, the highest score was the compound essential oil prepared from valerian latifolia essential oil 7 liters, lavender essential oil 3 liters, and dideal alcohol 90L in example 2.
The data in tables 1-4 are used to calculate the integrated score of sedation and sleep-aid effect and fragrance evaluation, specifically, the integrated score is (cross-longitudinal line (score) + standing buttress (score) + sleep-aid (score)) + 3 × 50% + fragrance (score) × 50%, wherein, the cross-longitudinal line (score) = (cross-longitudinal line frequency change rate ÷ positive drug group cross-longitudinal line frequency change rate) × 100, the standing buttress (score) = (standing buttress frequency change rate ÷ positive drug group standing buttress frequency change rate) × 100, the sleep-aid (score) = (compound essential oil group sleep-aid rate ÷ positive drug group sleep-aid rate) × 100, the fragrance (score) = average score × 10, and the specific integrated score result is shown in table 5.
TABLE 5 comprehensive score results table
| Group of | Across the vertical line (score) | Standing buttress (score) | Aid sleep (score) | Aroma (score) | Composite score |
| Example 1 | 20.51 | 38.08 | 0.00 | 52.80 | 36.17 |
| Example 2 | 55.90 | 56.77 | 0.00 | 65.60 | 51.58 |
| Example 3 | -34.85 | 20.24 | 80.00 | 53.30 | 37.55 |
| Example 4 | 33.38 | 55.45 | 40.00 | 47.80 | 45.37 |
| Example 5 | 14.88 | 32.57 | 60.00 | 58.90 | 47.36 |
As can be seen from the data in tables 1 to 5, the compound essential oil prepared in example 2 has better smell, strong sedative effect and highest comprehensive score, so that the compound essential oil sedative sleep-aiding bar prepared by selecting the volume ratio of 7:3 is more safe than oral administration drugs by adopting inhalation administration, can avoid daytime hangover, eliminate first-pass effect and gastrointestinal tract irritation, and can avoid skin reaction such as allergic dermatitis compared with external application, and in addition, the aromatic inhalation therapy can avoid the pain and rejection of swallowing oral drugs for patients, so that the patients can accept the compound essential oil sedative sleep-aiding bar more easily. The data prove that the valerian latifolia essential oil has a sedative sleep-aiding effect when inhaled and administered, the sedative sleep-aiding effect is stronger than that of lavender essential oil, and the sedative sleep-aiding effect of the compound essential oil is stronger than that of the compound essential oil when the valerian latifolia essential oil or the lavender essential oil is singly adopted, so that the sedative sleep-aiding effect of each single essential oil in the compound essential oil is different, the compound essential oil can be used synergistically, the smell of the compound essential oil is better and is easier to accept by people, the smell can be adjusted by adding the lavender essential oil into the valerian latifolia essential oil, the compound essential oil prepared in the embodiment 2 has different influences on the sedative sleep-aiding effect and the smell by using different proportions of the valerian latifolia essential oil and the lavender essential oil in a compounding mode, on the basis of giving consideration to the sedative sleep-aiding effect and.
The compound essential oil has the beneficial effects that the compound essential oil prepared by the embodiment of the invention has excellent sedative sleep-aiding effect, can be inhaled into a nasal cavity by adopting an aromatic inhalation therapy, acts on a central nervous system through reasonable compatibility of valerian latifolia essential oil and lavender essential oil by an olfactory pathway, plays a sedative sleep-aiding effect, is smeared on places with thin skin and good transdermal absorption effect such as the back of ears, the inner side of lower arms and the like, and can rapidly enter blood to play a sedative sleep-aiding effect; moreover, the aromatic inhalation therapy is adopted, so that mild insomnia can be relieved or other medicines can be assisted to treat severe insomnia, compared with oral medicines, the safety is high, the daily hangover can be avoided, the first-pass effect can be eliminated, and gastrointestinal tract irritation can be avoided; the compound essential oil provided by the invention is simple in preparation method, easy in raw material obtaining, and suitable for industrial production, and solves the problems that most of the existing medicines for treating insomnia need to be orally taken, adverse reactions such as daytime sleepiness, withdrawal symptoms, rebound insomnia and the like can occur after long-term use, and the safety is not high.
The valerian latifolia essential oil and the lavender essential oil used in the invention are obtained by steam distillation extraction, the sources are natural, the used solvent is dideal alcohol, and the smell is not irritating; meanwhile, the raw materials of the invention are conventional and easily available, the preparation steps have no special process requirements, and the invention is suitable for industrial production; the aromatic inhalation therapy is high in safety, has the effects of calming and helping sleep, can relieve mild insomnia or assist other medicines to treat severe insomnia, is high in safety compared with oral medicines, and can avoid daytime hangover, eliminate first-pass effect and stimulate gastrointestinal tracts.
It should be further noted that valerian for calming and sleep-aiding in the market at present mainly takes valerian officinalis as a raw material, wherein valerian officinalis is a valerian plant of Valerianaceae, and researches show that oral administration of an extract and inhalation of volatile oil of the valerian officinalis have the effects of calming and sleep-aiding and are mainly used for calming and sleep-aiding. At present, valerian latifolia is a valerian plant, belongs to the same genus as valerian officinalis, and has similar volatile oil composition, researches prove that the alcohol extract of valerian latifolia has the functions of calming and sleep aiding when taken orally, and the volatile oil has the functions of calming and sleep aiding when inhaled and administered for the first time. The volatile oil of the valerian latifolia has been industrially extracted and is mainly used in the cigarette industry, and the volatile oil is not easily accepted by people due to the specificity of volatile oil gas, so that the application of the valerian latifolia in calming and sleep aiding is limited. The innovation points of the invention are as follows: the raw materials of the valerian latifolia essential oil and lavender essential oil are administered in a compound use mode, so that the sleep aiding effect can be improved, the special smell of the valerian latifolia essential oil can be improved, the problem of poor smell of the valerian latifolia essential oil is solved while the curative effect is ensured, and the development of valerian latifolia and the reasonable utilization of resources are promoted. In addition, the invention adopts inhalation administration, has excellent effects of calming and helping sleep, the aromatic inhalation therapy acts on the central nervous system through olfactory pathways, compared with oral drugs, the aromatic inhalation therapy has strong safety, can avoid daytime hangover, eliminate first-pass effect and irritation to gastrointestinal tract, and simultaneously can avoid skin reaction such as allergic dermatitis compared with external application, and in addition, the aromatic inhalation therapy can avoid the pain and rejection of swallowing oral drugs for patients, so that the patients can accept the aromatic inhalation therapy more easily.
While the preferred embodiments of the present invention have been described in detail, the present invention is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present invention within the knowledge of those skilled in the art. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications of the invention may be made without departing from the scope of the invention.
Claims (10)
1. The compound essential oil is characterized by comprising the following raw materials in parts by weight: valerian latifolia essential oil, lavender essential oil and a proper amount of solvent; wherein the volume ratio of the valerian latifolia essential oil to the lavender essential oil is 1-9: 9-1.
2. The compound essential oil of claim 1, wherein the volume ratio of valerian latifolia essential oil to lavender essential oil is 4-7: 5-3.
3. The compound essential oil according to claim 1, wherein the solvent is selected from one or more of water, ethanol and glycerol.
4. The compound essential oil of claim 1, wherein the amount of the solvent is 5-10 times of the total volume of the valerian latifolia essential oil and the lavender essential oil.
5. The compound essential oil of claim 3, wherein the solvent is dideal alcohol.
6. A method for preparing the compound essential oil as claimed in any one of claims 1 to 5, which comprises the following steps:
1) weighing valerian latifolia essential oil and lavender essential oil according to a proportion, uniformly mixing, and adding a solvent for mixing to obtain a mixture;
2) and aging the mixture to obtain the compound essential oil.
7. The method for preparing compound essential oil according to claim 6, wherein the aging is carried out for 40-50 hours under the condition of avoiding light, and the temperature condition of the aging is 8-15 ℃.
8. A compound essential oil prepared by the preparation method of claim 6 or 7.
9. A formulation comprising, in part or in whole, the essential oil of claim 1 or 2 or 3 or 4 or 5 or 8.
10. Use of the formulation of claim 9 in the manufacture of a medicament for the treatment of insomnia.
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815026A (en) * | 2015-03-12 | 2015-08-05 | 林翔云 | Hypnotic essential oil composition |
| CN105188726A (en) * | 2013-01-21 | 2015-12-23 | 李京馥 | Massage oil for deep sleep |
| WO2017003395A1 (en) * | 2015-07-02 | 2017-01-05 | Entovest İlaç Ki̇mya Ve Teknoloji̇ Araştirma Merkezi̇ San. Ti̇c. Ltd. Şti̇. | Nanoencapsulated mosquito-, fly- and tick-repellent formulation |
| CN106573029A (en) * | 2014-07-14 | 2017-04-19 | 威玛舒培博士公司 | Combination of valerian root extract and lavender oil for use in the treatment of sleep disorders |
| CN106729068A (en) * | 2016-12-23 | 2017-05-31 | 曾惠民 | A kind of external application energy gauging that can be helped for sleep and preparation method thereof |
| CN110152046A (en) * | 2019-05-05 | 2019-08-23 | 上海应用技术大学 | A kind of fragrant atmosphere essence and preparation method thereof with effects of tranquilizing and allaying excitement ingredient |
| CN110179696A (en) * | 2019-06-27 | 2019-08-30 | 东莞怀朴植物精油有限公司 | A kind of assisting sleep compound essential oil and preparation method thereof |
-
2020
- 2020-04-13 CN CN202010283194.6A patent/CN111388572A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105188726A (en) * | 2013-01-21 | 2015-12-23 | 李京馥 | Massage oil for deep sleep |
| CN106573029A (en) * | 2014-07-14 | 2017-04-19 | 威玛舒培博士公司 | Combination of valerian root extract and lavender oil for use in the treatment of sleep disorders |
| CN104815026A (en) * | 2015-03-12 | 2015-08-05 | 林翔云 | Hypnotic essential oil composition |
| WO2017003395A1 (en) * | 2015-07-02 | 2017-01-05 | Entovest İlaç Ki̇mya Ve Teknoloji̇ Araştirma Merkezi̇ San. Ti̇c. Ltd. Şti̇. | Nanoencapsulated mosquito-, fly- and tick-repellent formulation |
| CN106729068A (en) * | 2016-12-23 | 2017-05-31 | 曾惠民 | A kind of external application energy gauging that can be helped for sleep and preparation method thereof |
| CN110152046A (en) * | 2019-05-05 | 2019-08-23 | 上海应用技术大学 | A kind of fragrant atmosphere essence and preparation method thereof with effects of tranquilizing and allaying excitement ingredient |
| CN110179696A (en) * | 2019-06-27 | 2019-08-30 | 东莞怀朴植物精油有限公司 | A kind of assisting sleep compound essential oil and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| KOMORI TERUHISA，等: "The sleep-enhancing effect of valerian inhalation and sleep-shortening effect of lemon inhalation", 《CHEMICAL SENSES》 * |
| 田玉红，等: "植物精油资源及其在烟草工业中的应用 ", 《广东化工》 * |
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