CN112336760A - Application of sweet wormwood herb volatile oil in improving sleep - Google Patents
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Abstract
The invention discloses application of sweet wormwood herb volatile oil in improving sleep. The invention relates to a sweet wormwood herb volatile oil with a sleep improving function, which can improve sleep disorder and assist sleep through different administration modes and has the characteristics of small dosage, quick response and high safety.
Description
Technical Field
The invention belongs to the field of medicines, and particularly relates to application of a traditional Chinese medicine extract namely sweet wormwood volatile oil.
Background
Sleep occupies about 1/3 hours of human life, is closely related to human health and working ability, and is the most basic and necessary process in the life evolution process. High quality sleep not only promotes recovery of nerve cell function, but also enhances the connection between nerve cells. With the development of society and the acceleration of life rhythm, the incidence rate of sleep disorder tends to increase year by year. Statistically, about 27% of people worldwide suffer from sleep disorders, and about 3 hundred million adults in our country have sleep disorders of varying degrees. Sleep deprivation causes a decline in cognitive abilities and emotional processing abilities, such as work efficiency, memory ability, and decision making, of the person. The long-time sleep disorder can cause the reduction of the immunologic function of a human body, easily cause hypertension, diabetes, cardiovascular and cerebrovascular diseases and various gastrointestinal diseases, lead the hypofunction of the brain and the hypogonadism of the human body, cause the aging of the organism and even cause neurological diseases such as encephalatrophy, senile dementia, Parkinson's syndrome, schizophrenia and the like. Sleep disorder diseases have become a global important social problem, causing great harm to patients and society.
Insomnia is also called sleep disorder and sleep maintenance disorder, and is the most common sleep disorder disease in clinic, caused by various reasons, such as difficulty in falling asleep, too short sleep depth or frequency, early awakening, insufficient sleep time or poor quality. Insomnia is developed in people of all ages, and teenagers are prone to poor sleep and poor sleep quality due to excessive mental labor, poor bearing capacity of a nervous system, excessive learning pressure, wrong sleep cycle and the like, and are high-incidence people suffering from insomnia. Studies have shown that insufficient sleep results in a significant increase in the probability of developing obesity and central obesity in adolescents by 14.5% and 12.5%. Although insomnia is not a critical disease, it can hamper people's normal life, work and study, reduce quality of life, and aggravate or induce symptoms such as palpitation, thoracic obstruction, vertigo, headache, and apoplexy.
At present, western medicines are mainly used for treating insomnia, and commonly used medicines for improving sleep mainly comprise pentobarbital, benzodiazepines such as diazepam and barbiturates such as phenobarbital. The medicines can improve sleep and relieve sleep disorder to a certain extent, but long-term administration of the hypnotic medicines can cause patients to rely on the medicine property, and can also cause a series of adverse reactions, such as memory decline, cognitive function impairment, hangover and the like. Meanwhile, the intractable insomnia can be caused by the rebound after stopping taking the medicine, and the long-term pain and psychological burden are brought to the patient.
At present, researches on the sweet wormwood herb volatile oil mainly focus on the aspects of component determination, cough and asthma relieving, bacteriostatic activity and the like, and reports on hypnosis and sleep improvement are not available for a while.
Disclosure of Invention
The invention aims to provide application of sweet wormwood volatile oil in improving sleep so as to solve the problems mentioned in the background.
One of the technical schemes adopted by the invention for solving the technical problems is as follows:
application of herba Artemisiae Annuae volatile oil in preparing medicine for improving sleep is provided.
Wherein the herba Artemisiae Annuae volatile oil is yellowish to dark yellow clear liquid obtained by steam distillation from whole plant of Artemisia annua Linn (Artemisia annua, and Artemisia annua) belonging to Artemisia of Compositae, and has specific fragrance.
Preferably, the sweet wormwood volatile oil is extracted from fresh sweet wormwood herbs. The content of volatile oil in fresh product is high.
The sweet wormwood volatile oil contains camphene, beta-pinene, artemisone, levocamphor, beta-caryophyllene, 1, 8-cineole, vanillyl alcohol, benzyl isovalerate, beta-farnesene, beta-caryophyllene and the like. In a specific embodiment, the artemisia apiacea volatile oil contains 7.5-8% of camphene, 7-7.5% of beta-pinene, 16.5-17% of artemisone, 24.5-25% of levocamphor, 12.5-13% of beta-caryophyllene and 14.5-15.5% of 1, 8-cineole, vanillyl alcohol, benzyl isovalerate, beta-farnesene and beta-caryophyllene in total.
The second technical scheme adopted by the invention for solving the technical problems is as follows:
application of a composition containing the above herba Artemisiae Annuae volatile oil in preparing medicine for improving sleep is provided.
Further, the composition also comprises barbiturates and benzodiazepine
Quasi-drugs or non-benzodiazepines
At least one of the quasi-drugs.
Wherein the bar ratioExamples of the barbiturates include phenobarbital (luminal), barbital, pentobarbital sodium, amobarbital, secobarbital, or thiopental sodium; the dinitrogen benzene
Examples of such agents include triazolam, oxazepam (desmethoxydiazepam), alprazolam, estazolam, lorazepam, temazepam, clonazepam, diazepam (diazepam), fluazepam (fluxapam), clonazepam
(chlordiazepoxide) or quazepam, etc.; the non-benzodiazepine
Examples of such drugs include chloral hydrate, meprobamate (meprobamate), zolpidem (kintos), zopiclone (zopiclone), or zaleplon.
In the present invention, the improving sleep includes prolonging sleep time or shortening sleep latency.
Further, the dosage form of the medicament comprises aerosol or injection, and can be used for atomization inhalation or injection. The injection includes, for example, subcutaneous injection, intramuscular injection, or intraperitoneal injection; such as respiratory inhalation aerosols; the sleep improving medicine can be inhaled by intraperitoneal injection or atomization.
The aerosol is a preparation which is prepared by filling the sweet wormwood volatile oil in a pressure-resistant container with a special device, or filling the sweet wormwood volatile oil and a proper propellant in the pressure-resistant container with the special device, and spraying the content in a fine mist shape, a foam shape or other shapes by means of the pressure of the propellant when in use.
In the invention, the sweet wormwood volatile oil can be directly prepared into a conventional preparation formulation comprising the preparation formulation by a conventional method, and can also be prepared into a conventional preparation formulation comprising the preparation formulation by a conventional method together with at least one pharmaceutically acceptable auxiliary material or carrier.
In the present invention, the pharmaceutically acceptable adjuvant or carrier includes, but is not limited to, diluents, solvents, excipients, absorbents, wetting agents, adhesives, disintegrants, lubricants, solubilizers, emulsifiers, suspending agents, surfactants, film forming agents, propellants, antioxidants, flavoring agents, fragrances, bactericides, preservatives, etc.; the carrier is a system which can carry a compound, has the functions of changing the mode of the compound entering a human body and the distribution of the compound in the body, controlling the release speed to achieve controlled release or sustained release, targeting delivery to target organs and the like, and comprises but is not limited to liposome, microsphere, microcapsule, solid dispersion, micelle, microemulsion, gel, sustained release carrier, controlled release carrier, targeting carrier, nanoparticle material and the like.
The third technical scheme adopted by the invention for solving the technical problems is as follows:
application of herba Artemisiae Annuae volatile oil in preparing health product for improving sleep is provided.
In the present invention, the health supplementary product includes, for example, a sachet, a balm, a pillow core, etc., which can be placed aside during sleeping to produce a sleep assisting or improving effect by inhalation.
The fourth technical scheme adopted by the invention for solving the technical problems is as follows:
use of a composition comprising volatile oil of Artemisia annua for preparing health product for improving sleep is provided.
Further, the composition for preparing the health auxiliary product for assisting sleep improvement, which comprises the sweet wormwood volatile oil, can also comprise other components which are helpful for improving sleep, such as lavender essential oil and the like, besides the sweet wormwood volatile oil.
The equipment, reagents, processes, parameters and the like related to the invention are conventional equipment, reagents, processes, parameters and the like except for special description, and no embodiment is needed.
All ranges recited herein include all point values within the range.
In the present invention,% is mass% unless otherwise specified.
Compared with the background technology, the technical scheme has the following advantages:
1. the invention provides the sweet wormwood volatile oil for improving sleep, and the sweet wormwood is a traditional Chinese medicine, has the advantages of strong sleep improving effect and small toxic and side effects, and has important significance for improving national health level and life quality.
2. The invention adopts the sleep experiment of the sodium pentobarbital with the subthreshold dose and the suprathreshold dose, and researches the hypnosis and the sleep improvement effect of the sweet wormwood herb volatile oil by observing the indexes of the number of mice in sleep, the sleep latency, the sleep duration and the like. Pharmacological experiments show that the sweet wormwood herb volatile oil has good hypnotic and sleep improving effects and can be used for preparing the medicines for hypnotizing and improving sleep.
3. The sweet wormwood herb volatile oil for treating sleep disorder can play the drug effects of hypnosis and sleep improvement in a short time through intraperitoneal injection and aerosol inhalation administration, has stable curative effect and high safety, and can be used for preparing clinical pharmaceutical preparations and products for hypnosis and sleep improvement.
Drawings
FIG. 1 is a graph showing the effect of inhalation administration of volatile oil of Artemisia annua in example 4 on reduction of sleep latency in mice.
FIG. 2 is a graph showing the effect of the inhalation administration of the volatile oil of Artemisia annua in example 4 on the prolongation of sleep time in mice.
Detailed Description
The invention is further illustrated by the following figures and examples. It should be noted that the following examples illustrate the present invention by in vivo pharmacological experiments of hypnosis and sleep improvement of the volatile oil of artemisia apiacea, but do not represent that the present invention is limited to the examples.
Example 1 extraction of volatile Artemisia annua oil
Experimental materials: plant essential oil extraction equipment (a distillation still, a cooling pipe and an oil collector).
The experimental method comprises the following steps: putting fresh herba Artemisiae Annuae into a distillation device, adding water into a distillation kettle to screen surface, and directly heating and distilling. And starting distillation with strong fire to ensure that enough steam is in the distillation pot, and when the sweet wormwood herb raw material is heated and softened and oily liquid is discharged from the cooling pipe, uniformly evaporating the steam with slow fire. Collecting the distillate in an oil collector, and continuously removing water layer to obtain yellowish-orange clear flowing oily liquid as herba Artemisiae Annuae volatile oil.
The main components of the sweet wormwood herb volatile oil are as follows:
example 2 synergistic Effect of Artemisia annua volatile oil on sleep of mice induced by suprathreshold dose of sodium pentobarbital
Experimental materials: c57BL/6J mice (18-20 g, male) 32 mice, sodium pentobarbital.
The experimental method comprises the following steps: mice are randomly divided into 8 groups of blank control group and high, medium and low dose groups of sweet wormwood volatile oil respectively, the experimental groups are respectively perfused with stomach sweet wormwood volatile oil (0.3mL/kg, 0.15mL/kg, 0.075mL/kg), the blank groups are perfused with stomach 0.3mL/kg distilled water, after 3 days of continuous administration, all mice are injected with pentobarbital sodium (35mg/kg) in the abdominal cavity in the morning next day, the time from administration to disappearance of mouse righting reflex is observed and recorded as sleep latency (S), and the time from disappearance of righting reflex to restoration of mouse righting reflex is sleep time (min)
The results are shown in Table 1: therefore, the sweet wormwood volatile oil and the sodium pentobarbital with suprathreshold dosage can obviously shorten the sleep latency of the mouse and prolong the sleep time.
TABLE 1 synergistic effect of different doses of volatile Artemisia annua oil on sleep of mice induced by suprathreshold dose of sodium pentobarbital
Note: p <0.01, P <0.05 compared to the blank control group.
Example 3 synergistic Effect of Artemisia annua volatile oil on sleep of mice induced by subthreshold dose of sodium pentobarbital
Experimental materials: c57BL/6J mice (18-20 g, male) 32 mice, sodium pentobarbital.
The experimental method comprises the following steps: the mice are randomly divided into 8 groups of blank control groups and 8 groups of high, medium and low doses of volatile oil of sweet wormwood, the experimental groups are respectively irrigated with stomach volatile oil of sweet wormwood (0.3mL/kg, 0.15mL/kg and 0.075mL/kg), the blank groups are irrigated with stomach 0.3mL/kg of distilled water, after 3 days of continuous administration, all mice are injected with pentobarbital sodium (30mg/kg) in the abdominal cavity in the morning next day, the sleep is generated when the righting reflex of the mice disappears for 1min within 30min, and the percentage of the mice in each group falling asleep is counted.
The results are shown in Table 2: the low-dose group and the medium-dose group of the artemisia apiacea volatile oil can increase the percentage of falling asleep of mice, but the effect of the high-dose artemisia apiacea volatile oil is less obvious, and the application of the artemisia apiacea volatile oil in sleep promotion is prompted to be in a proper dose range, for example, 0.07-0.2 mL/kg for the mice.
TABLE 2 synergistic effect of different doses of volatile Artemisia annua oil on sleep of mice induced by subthreshold dose of sodium pentobarbital
Example 4 synergistic Effect of inhaled administration of Artemisia annua volatile oil on sleep of mice induced by sodium pentobarbital
Experimental materials: 16C 57BL/6J mice (18-20 g, male) were treated with sodium pentobarbital.
The experimental method comprises the following steps: the mice are randomly divided into 8 mice respectively in a normal control group and an experimental group, the experimental group continuously inhales and administers sweet wormwood herb volatile oil for 30min by atomization, then all the mice are injected with pentobarbital sodium (40mg/kg) in the abdominal cavity, the time from administration to disappearance of mouse righting reflex is taken as sleep latency (S), and the time from disappearance of righting reflex to recovery is taken as sleep time (min).
The experimental results are shown in table 3, fig. 1 and fig. 2: therefore, the sweet wormwood volatile oil is atomized and inhaled to be cooperated with the pentobarbital sodium, so that the sleep latency of the mouse can be obviously shortened, and the sleep time can be prolonged.
TABLE 3 synergistic effect of inhaled administration of volatile Artemisia annua oil on sleep of mice induced by sodium pentobarbital
Note: p <0.01, P <0.05 compared to normal controls.
The above description is only a preferred embodiment of the present invention, and therefore should not be taken as limiting the scope of the invention, which is defined by the appended claims and their equivalents.
Claims (10)
1. Application of herba Artemisiae Annuae volatile oil in preparing medicine for improving sleep is provided.
2. Application of a composition containing herba Artemisiae Annuae volatile oil in preparing medicine for improving sleep is provided.
3. Application of herba Artemisiae Annuae volatile oil in preparing health product for improving sleep is provided.
4. Use of a composition comprising volatile oil of Artemisia annua for preparing health product for improving sleep is provided.
5. Use according to any one of claims 1 to 4, characterized in that: the improving sleep comprises prolonging sleep time or shortening sleep latency.
6. Use according to any one of claims 1 to 4, characterized in that: the herba Artemisiae Annuae volatile oil is obtained by steam distillation of whole plant of herba Artemisiae Annuae of Artemisia of Compositae.
7. Use according to any one of claims 1 to 4, characterized in that: the sweet wormwood volatile oil contains camphene, beta-pinene, artemisone, levocamphor, beta-caryophyllene, 1, 8-cineole, vanillyl alcohol, benzyl isovalerate, beta-farnesene and beta-caryophyllene.
8. Use according to claim 7, characterized in that: the content of camphene in the sweet wormwood herb volatile oil is 7.5-8%; the content of the beta-pinene in the sweet wormwood herb volatile oil is 7-7.5%; the content of the artemisone in the artemisia apiacea volatile oil is 16.5-17%; the content of the levo-camphor in the sweet wormwood herb volatile oil is 24.5-25%; the content of the beta-caryophyllene in the sweet wormwood herb volatile oil is 12.5-13%; the total content of the 1, 8-cineole, the vanillyl alcohol, the benzyl isovalerate, the beta-farnesene and the beta-caryophyllene in the sweet wormwood herb volatile oil is 14.5-15.5%.
9. Use according to claim 1 or 2, characterized in that: the dosage form of the medicament comprises aerosol or injection.
10. Use according to claim 2, characterized in that: the composition also comprises barbiturates and benzodiazepine
Quasi-drugs or non-benzodiazepines
At least one of the quasi-drugs.
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| CN202011240532.4A CN112336760A (en) | 2020-11-09 | 2020-11-09 | Application of sweet wormwood herb volatile oil in improving sleep |
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- 2020-11-09 CN CN202011240532.4A patent/CN112336760A/en active Pending
Non-Patent Citations (3)
| Title |
|---|
| FABIO F.PERAZZO等: "Effect of Artemisia annua L.leaves essential oil and ethanol extract on behavioral assays", 《BRAZILIAN JOURNAL OF PHARMACOGNOSY》 * |
| 一老医生: "青蒿，原来也是神奇的失眠草，看名医名方和青蒿香薰治失眠", 《HTTPS://TIEBA.BAIDU.COM/P/6493381983》 * |
| 佘金明等: "青蒿挥发油成分的GC-MS分析与化学计量学解析法", 《中成药》 * |
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