CN107412343B

CN107412343B - Refreshing spray and preparation method thereof

Info

Publication number: CN107412343B
Application number: CN201710307445.8A
Authority: CN
Inventors: 李泯; 赵志远
Original assignee: Hunan Qingmuqing Biotechnology Co ltd
Current assignee: Hunan Qingmuqing Biotechnology Co ltd
Priority date: 2017-05-04
Filing date: 2017-05-04
Publication date: 2020-09-22
Anticipated expiration: 2037-05-04
Also published as: CN107412343A

Abstract

The invention relates to the field of pharmacy, and in particular relates to refreshing spray and a preparation method thereof. The refreshing spray is mainly prepared from various raw materials, wherein the various raw materials comprise, by weight, 1-5 parts of menthol, 0.5-2.5 parts of camphor, 1-5 parts of eucalyptus oil, 0.5-2.5 parts of perilla leaf oil, 0.5-2.5 parts of clove oil and 0.5-2.5 parts of patchouli oil. The synergistic effect of the medicines can relieve the symptoms of fatigue, drowsiness and the like of a human body, improve the mental state of the human body, and simultaneously has certain relieving effect on dizziness, carsickness, exopathic wind-cold and the like.

Description

Refreshing spray and preparation method thereof

Technical Field

The invention relates to the field of pharmacy, and in particular relates to refreshing spray and a preparation method thereof.

Background

Modern people often work overtime and stay up night, and the pressure of working is big and lead to people night sleep not enough and then make daytime produce symptoms such as sleepy, tired easily, and then reduce work efficiency. Meanwhile, the immunity of the human body is easily reduced due to insufficient sleep, so that the occurrence probability of cold is increased. In order to quickly relieve fatigue, people generally adopt a refreshing agent to stimulate the brain so as to achieve the effect of refreshing, but the existing refreshing substance can only simply refresh and cannot prevent cold.

Disclosure of Invention

The invention aims to provide refreshing spray which can quickly and effectively eliminate symptoms of human body fatigue, drowsiness, dizziness and the like and can prevent cold at the same time.

The invention also aims to provide a method for preparing refreshing spray, the refreshing spray can be quickly prepared by the method, and meanwhile, the method is simple in operation steps, mild in operation conditions, easy to realize, easy in raw material obtaining and has a wide industrial application prospect.

The technical problem to be solved by the invention is realized by adopting the following technical scheme:

the invention provides a refreshing spray which is mainly prepared from various raw materials. The various raw materials comprise 1 to 5 portions of menthol, 0.5 to 2.5 portions of camphor, 1 to 5 portions of eucalyptus oil, 0.5 to 2.5 portions of perilla leaf oil, 0.5 to 2.5 portions of clove oil and 0.5 to 2.5 portions of patchouli oil by weight portion.

The invention provides a method for preparing refreshing spray, which comprises the following steps: mixing 1-5 parts of menthol, 0.5-2.5 parts of camphor, 1-5 parts of eucalyptus oil, 0.5-2.5 parts of perilla leaf oil, 0.5-2.5 parts of clove oil and 0.5-2.5 parts of patchouli oil in parts by weight, and canning.

The refreshing spray provided by the embodiment of the invention has the beneficial effects that: the menthol, camphor, eucalyptus oil, perilla leaf oil and the like act on organs such as cold receptors to enable a human body to generate cool feeling, so that the brain is stimulated to excite, and the effects of refreshing and resisting fatigue are realized. Meanwhile, the menthol, the camphor, the eucalyptus oil, the perilla leaf oil, the clove oil and the patchouli oil interact with each other to promote the blood circulation of a human body, increase the blood and oxygen content of the brain, improve the symptoms of cerebral anoxia, cerebral ischemia and the like, and further realize the effect of refreshing. Meanwhile, the mucosa can be stimulated through the interaction of the menthol, the camphor and the like, so that the capillary vessels can be contracted, and the symptoms of nasal obstruction, rhinorrhea, dizziness and the like caused by the wind-cold type common cold can be further relieved.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

In the description of the present invention, it should be noted that the terms "first", "second", and the like are used only for distinguishing the description, and are not intended to indicate or imply relative importance.

The refreshing spray and the method of preparing the refreshing spray according to the embodiment of the present invention will be described in detail below.

The refreshing spray provided by the embodiment of the invention is mainly prepared from various raw materials. The various raw materials comprise 1 to 5 portions of menthol, 0.5 to 2.5 portions of camphor, 1 to 5 portions of eucalyptus oil, 0.5 to 2.5 portions of perilla leaf oil, 0.5 to 2.5 portions of clove oil and 0.5 to 2.5 portions of patchouli oil by weight portion. More preferably, the various raw materials comprise 3-4 parts of menthol, 1-2 parts of camphor, 3-4 parts of eucalyptus oil, 1-2 parts of perilla leaf oil, 1-2 parts of clove oil and 1-2 parts of patchouli oil.

The refreshing spray prepared by the proportion can jointly improve the human body excitability by the synergistic effect, and relieve the symptoms of human body fatigue, sleepiness and the like. Specifically, the menthol, camphor, eucalyptus oil, perilla leaf oil and the like act on organs such as cold receptors to enable a human body to generate cool feeling, so that the brain is stimulated to excite, and the effects of refreshing and resisting fatigue are realized. Meanwhile, the menthol, the camphor, the eucalyptus oil, the perilla leaf oil, the clove oil and the patchouli oil interact with each other to promote the blood circulation of a human body, increase the blood and oxygen content of the brain, improve the symptoms of cerebral anoxia, cerebral ischemia and the like, and further realize the effect of refreshing. Meanwhile, the mucosa can be stimulated through the interaction of the menthol, the camphor and the like, so that the capillary vessels can be contracted, and the symptoms of nasal obstruction, rhinorrhea, dizziness and the like caused by the wind-cold type common cold can be further relieved.

The menthol is white crystal extracted from leaf and stem of herba Menthae, and has molecular formula C₁₀H₂₀O, is the main component in peppermint and peppermint essential oils. Menthol can selectively stimulate the cold receptors of human skin or mucous membrane to produce cold reflex and cold feeling; in addition, the blood vessels in deep tissues can be contracted to produce a therapeutic effect. The menthol has the effects of stimulating mucous membranes to generate cooling feeling, stimulating the brain to excite and realizing the effect of refreshing.

The Camphora is granular crystal extracted from branches, stems, leaves and roots of Cinnamomum camphora of Lauraceae. The Camphora has effects of dredging orifices, promoting qi stagnation, removing filth, killing parasites, relieving itching, and relieving swelling and pain. The camphor in the embodiment of the invention is used for exciting the central nerve, enhancing the respiration and the circulation of the human body, and simultaneously has an exciting effect on the blood vessel movement center.

The oleum Eucalypti is volatile oil obtained by steam distillation of Eucalyptus globulus Labill of Myrtaceae, Cinnamomum camphora of Lauraceae, or other plants of the same genus of the above two families. The oleum Eucalypti has antituberculosis, burn and dysentery treating, and disinfectant effects. In the embodiment of the invention, the eucalyptus oil is mainly used for sterilizing, refreshing and reviving the mind.

The perilla leaf oil is volatile oil obtained by steam distilling leaves or twigs of Perilla Britt of Labiatae. Perilla leaf oil has effects of reducing blood lipid, improving memory, resisting aging and resisting allergy. Specifically, the perilla leaf oil is used for relieving exterior syndrome and dispelling cold in the embodiment of the invention, and can prevent the wind-cold type common cold.

The oleum Caryophylli is volatile oil obtained by distilling dried flower bud of Syzygium aromaticum (L.) of Myrtaceae. Has the effects of warming stomach, lowering adverse qi, warming kidney, and relieving pain. In the embodiment of the invention, clove oil is used for relieving sleepiness and listlessness, has the stimulation effect and can strengthen memory and stimulate depressed mood.

Patchouli oil is a natural oil with woody, loamy and herbal fragrances. Patchouli has outstanding effects of eliminating turbid pathogen with aromatics, stimulating the appetite, arresting vomiting and relieving summer-heat, so that the patchouli is an essential medicine for treating damp turbidity obstruction in middle-jiao, epigastric fullness and vomiting, summer-heat dampness and lassitude, chest distress and discomfort, cold-dampness retention and summer-heat, abdominal pain, vomiting and diarrhea in traditional Chinese medicine. The patchouli oil in the embodiment of the invention has the functions of dissolving moisture and dispelling cold and relieving exterior syndrome, and has good prevention and treatment effects on exogenous wind-cold caused by summer heat.

Further preferably, the refreshing spray comprises a spray carrier, and the mass ratio of the spray carrier to the various raw materials is 6-11: 1. Within the proportion range, the refreshing spray contains a proper amount of effective components, and the spraying effect of the subsequent refreshing spray is ensured.

Further preferably, the spray carrier comprises 5 to 15 parts of water and 75 to 100 parts of an alcohol solvent. The water and alcohol solvent are mixed to be used as the spray carrier because the water and the alcohol solvent can be mixed and dissolved in any proportion to form the mixed solvent, so that the refreshing spray can simultaneously dissolve and mix the water-soluble and water-insoluble active ingredients, and further the treatment effect of each active ingredient can be effectively exerted.

Further preferably, the alcohol solvent is any one of ethanol, propylene glycol, and isopropyl alcohol. Ethanol, commonly known as alcohol, is the most common monohydric alcohol and is miscible with water in any ratio. Ethanol is a good solvent and can dissolve many substances, so that it is often used for dissolving medicinal components and is also often used for reaction solvents, which can increase the contact area between reactants and increase the reaction rate. Propylene glycol is miscible with water, ethanol and various organic solvents, and can be used as humectant, anticaking agent, antioxidant, etc. when used as carrier solvent. Isopropanol is an isomer of n-propanol, is a colorless transparent liquid, can be mixed and dissolved with alcohol, ether, chloroform and water, can dissolve various organic substances and some inorganic substances such as alkaloid, rubber, shellac, rosin, synthetic resin and the like, forms an azeotrope with water, and is insoluble in a salt solution. The isopropanol has strong dissolving capacity to lipophilic substances and ethanol.

Further preferably, the raw materials further comprise 1-2 parts of food additives, and further preferably, the food additives are any one of jasmine essence, rose essence, sandalwood essence and lemon essence. The food additive can improve the use sense of refreshing spray. The essence is a kind of concentrated aromatic oil synthesized by man to imitate the smell of fruit and natural perfume. It is an artificial perfume. The jasmine essence selected by the embodiment of the invention has certain functions of relieving depression, revivifying, improving confidence and activating blood and meridians. Can further improve the refreshing spray and revivify. The rose essence can stimulate the anterior lobe of the brain to secrete two hormones of nervone and nervone, so that the spirit is in the most comfortable state, and the rose essence can relieve brain fatigue, enhance mood and relieve nerve pressure and tension. The sandalwood essence can relieve mental stress, increase sense of fullness, relax the whole body and the like. The lemon essence can enhance the immune system, purify the body, promote the blood circulation, sooth and relieve the mood, and can revive the spirit.

The embodiment of the invention also provides a method for preparing the refreshing spray, which comprises the following steps:

dissolving 0.5-2.5 parts of camphor and 1-5 parts of menthol which are purchased in 75-100 parts of alcohol solvent at the temperature of 30-40 ℃. The camphor and the menthol are both solid, and in the process of preparing the refreshing spray, the camphor and the menthol are dissolved firstly to obtain the solid, and then the subsequent operation can be carried out. The solubility of camphor and menthol in alcohol organic solvents is superior to that in water, and therefore, dissolving both in alcohol solvents is an excellent choice.

Because the eucalyptus oil, the perilla leaf oil, the clove oil and the like are volatile oil, if the substances are directly added into the mixture of the menthol and the camphor alcohol solvent, the substances are easy to volatilize, so that the content and the proportion of the active ingredients in the refreshing spray are changed, and the treatment effect of the refreshing spray is reduced. Therefore, in order to solve this problem, it is preferable in the embodiment of the present invention that 1 to 2 parts of ice is added to the alcohol solvent in which menthol and camphor are dissolved to lower the temperature of the mixed alcohol solvent. Adding ice at 0-4 deg.C, adding 1-5 parts of oleum Eucalypti, 0.5-2.5 parts of Perilla leaf oil, 0.5-2.5 parts of oleum Caryophylli and 0.5-2.5 parts of oleum Pogostemonis, and mixing to obtain a first mixture.

Because the volatile oils are oily substances and have good solubility in organic solvents, the volatile oils are directly mixed with the organic solvents, so that the dissolution of each effective component is facilitated, and the treatment effect of refreshing spray is further improved.

Mixing oleum Eucalypti, folium Perillae oil, oleum Caryophylli and oleum Pogostemonis with alcohol solvent containing menthol and camphor, and mixing oleum Perillae, oleum Caryophylli and oleum Pogostemonis and alcohol solvent containing oleum Eucalypti. By adopting the mixing mode, the mixing can be more uniform. Firstly, the ratio of perilla leaf oil, clove oil and patchouli oil is equivalent, the equal quantity and the increasing mixing are easier to mix evenly, and the mixing is the key requirement of refreshing spray. If the mixing is not uniform, the content of the effective components may be different, and the effect of refreshing spray is further influenced.

Further preferably, 1-2 parts of food additive and 5-15 parts of water are further added to the mixed solution to dissolve the substances partially insoluble in the organic solvent and to promote the content of the active substances in the refreshing spray.

Further preferably, the raw materials are filtered after being mixed, so that solid substances possibly contained in the mixed solution are removed, the solid content in the refreshing spray is reduced, and the spraying effect of the refreshing spray prepared in the later stage is ensured.

And then sterilizing the filtered liquid obtained after filtering, removing pathogenic bacteria possibly contained in the filtered liquid, protecting the treatment effect of the refreshing spray, and simultaneously, prolonging the quality guarantee period of the refreshing spray. High-temperature sterilization cannot be adopted in the embodiment of the invention, because volatile oil is easy to volatilize at high temperature, the treatment effect of refreshing spray is further reduced. Meanwhile, volatile oil is volatilized and accumulated to a certain concentration, so that explosion is easy to occur, and further production accidents are caused. The sterilization mode adopted by the embodiment of the invention is the existing sterilization mode, such as radiation sterilization and damp-heat sterilization.

And (4) after the sterilization is finished, subpackaging the mixed solution of the raw materials by adopting the existing tank pressing method to obtain the spray. It should be noted that the refreshing spray according to the embodiment of the present invention may be used as other agents such as drops, paste, and the like.

The invention provides a refreshing spray which utilizes the synergistic effect of menthol, camphor, eucalyptus oil, perilla leaf oil, clove oil and other substances to jointly act on human brains, promote blood circulation, improve the states of human fatigue, sleepiness and the like, promote the excitation state of human bodies and further play a role in refreshing. Meanwhile, the refreshing spray can sterilize and prevent cold. And the preparation of the spray is more convenient for carrying and using.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

This example provides a refreshing spray, which is made primarily from a variety of raw materials. The raw materials include 1g of menthol, 2g of camphor, 4g of eucalyptus oil, 1g of perilla leaf oil, 2g of clove oil and 0.5g of patchouli oil.

The method for preparing the refreshing spray comprises the following steps:

1g of menthol and 2g of camphor were dissolved in 75g of ethanol at 30 ℃ and then mixed with 4g of eucalyptus oil. Mixing 1g of perilla leaf oil, 2g of clove oil and 0.5g of patchouli oil, mixing with ethanol, sterilizing and packaging.

Example 2

This example provides a refreshing spray, which is made primarily from a variety of raw materials. The raw materials include 5g of menthol, 1g of camphor, 1g of eucalyptus oil, 0.5g of perilla leaf oil, 2.5g of clove oil and 2g of patchouli oil.

The method for preparing the refreshing spray comprises the following steps:

5g of menthol and 1g of camphor were dissolved in 100g of isopropanol at 35 ℃ and then 2g of ice was added and mixed with 1g of eucalyptus oil at 0 ℃. Mixing 0.5g perilla leaf oil, 2.5g clove oil and 2g patchouli oil, mixing with isopropanol, adding 15g water, sterilizing, and packaging.

Example 3

This example provides a refreshing spray, which is made primarily from a variety of raw materials. The raw materials include 3g of menthol, 0.5g of camphor, 5g of eucalyptus oil, 2.5g of perilla leaf oil, 0.5g of clove oil, 2.5g of patchouli oil and 1.5g of rose essence.

The method for preparing the refreshing spray comprises the following steps:

3g of menthol and 0.5g of camphor were dissolved in 90g of propylene glycol at 40 ℃ and then 1g of ice was added and mixed with 5g of eucalyptus oil at 4 ℃. Mixing 2.5g perilla leaf oil, 0.5g clove oil and 2.5g patchouli oil, mixing with propylene glycol, adding 1.5g rose essence and 7g water, sterilizing, and packaging.

Example 4

This example provides a refreshing spray, which is made primarily from a variety of raw materials. The raw materials include 2g of menthol, 2.5g of camphor, 3g of eucalyptus oil, 1.5g of perilla leaf oil, 1g of clove oil, 1.5g of patchouli oil and 2g of lemon essence.

The method for preparing the refreshing spray comprises the following steps:

2g of menthol and 2.5g of camphor were dissolved in 85g of isopropanol at 32 ℃ and then 2g of ice was added and mixed with 3g of eucalyptus oil at 2 ℃. Mixing 1.5g perilla leaf oil, 1g clove oil and 1.5g patchouli oil, mixing with isopropanol, adding 2g lemon essence and 10g water, sterilizing, and packaging.

Example 5

This example provides a refreshing spray, which is made primarily from a variety of raw materials. The raw materials include 4g of menthol, 1.5g of camphor, 2g of eucalyptus oil, 1g of perilla leaf oil, 0.5g of clove oil, 1g of patchouli oil and 1g of sandalwood essence.

The method for preparing the refreshing spray comprises the following steps:

4g of menthol and 1.5g of camphor were dissolved in 75g of isopropanol at 37 ℃ and then 2g of ice was added and mixed with 2g of eucalyptus oil at 3 ℃. Mixing 1g perilla leaf oil, 0.5g clove oil and 1g patchouli oil, mixing with isopropanol, adding 1g sandalwood essence and 5g water, sterilizing and packaging.

Experimental example 1

Refreshment test

250 persons who have continuously worked for 12 hours and have not had a rest are selected and divided into 5 groups, and all the persons have symptoms of fatigue, sleepiness, lassitude and the like. The refreshing sprays of examples 1-5 were used to fill out the effect after 1 minute, 5 minutes, 2 hours and 6 hours of application of the spray, respectively. Among them, sleepiness, fatigue, recovery of energy, etc. are defined as effective. Specific results are shown in table 1.

TABLE 1 questionnaire for refreshing

As can be seen from table 1, after the refreshing spray of the embodiment of the present invention is used, at least 96% of people feel that symptoms such as fatigue and tiredness disappear within 1 minute, and the people are more spiritual, which indicates that the refreshing spray of the embodiment of the present invention has a fast effect, and can well promote the mental state of the people and improve fatigue. After the refreshing spray is used for 6 hours, nearly 60% of people still feel good in mental state, and the refreshing spray provided by the embodiment of the invention is long in action time and can improve the mental state of a human body for a long time.

Example 2

The 250 patients with wind-cold type common cold are divided into 5 groups, and the patients have the symptoms of severe aversion to cold, light fever, no sweat, headache, body pain, nasal obstruction, thin and white sputum, thirst or hot drink preference, thin and white fur and the like. The refreshing sprays of examples 1-5 were used to fill out the effect of use after 5 minutes, 2 hours and 6 hours of use of the spray, respectively.

Wherein, the effective symptoms of severe aversion to cold, light fever, no sweat, headache, body pain, nasal obstruction, thin and white sputum and the like are relieved. The obvious effect is defined as the disappearance of at least one symptom of severe chills, light fever, no sweat, headache, body pain, nasal obstruction, clear nasal discharge, cough, thin and white sputum and the like. Specific results are shown in table 2.

TABLE 2 wind-cold type common cold relieving condition questionnaire

According to table 2, the refreshing spray provided by the embodiment of the invention can effectively relieve the wind-cold type common cold. After 5 minutes using the refreshing spray of examples 1-5 of the present invention, at least 82% of patients had relieved certain symptoms of the wind-cold type of cold, wherein it was known that 20% of patients had disappeared symptoms of the wind-cold type of cold, indicating that the refreshing spray had a rapid onset of action for relieving the wind-cold type of cold. And the relieving effect on the common cold due to wind-cold is increased along with the increase of time. After the refreshing spray is used for 2 hours, the symptoms of certain wind-cold type cold of approximately 60% of patients disappear. However, with the increase of time, the effective components in the refreshing spray are volatilized or metabolized by human bodies, and the relieving effect on the wind-cold type common cold is reduced. When 6 hours after application of the refreshing spray, only 30% of patients felt significant and nearly 60% showed significant. The refreshing spray disclosed by the embodiment of the invention can be used for relieving the wind-cold type common cold.

In conclusion, the refreshing spray of the embodiments 1 to 5 of the present invention utilizes the combined action of the menthol, the camphor, the eucalyptus oil, the perilla leaf oil and the like to relieve the symptoms of fatigue, sleepiness and the like of the human body, and simultaneously has certain treatment effect on the symptoms of dizziness, carsickness and the like. The refreshing spray provided by the embodiment of the invention also has the effect of relieving the wind-cold type common cold. The refreshing spray provided by the embodiment of the invention achieves the effects of refreshing and relieving fatigue by exciting the brain of a human body, promoting blood circulation and increasing oxygen supply and blood supply of the brain.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims

1. The refreshing spray is characterized by being prepared from various raw materials and a spray carrier, wherein the various raw materials comprise, by weight, 1-5 parts of menthol, 0.5-2.5 parts of camphor, 1-5 parts of eucalyptus oil, 0.5-2.5 parts of perilla leaf oil, 0.5-2.5 parts of clove oil, 0.5-2.5 parts of patchouli oil and 1-2 parts of food additives;

the spray carrier is 5-15 parts of water and 75-100 parts of alcohol solvent;

the mass ratio of the spraying carrier to the various raw materials is 6-11: 1.

2. The refreshing spray according to claim 1, wherein the plurality of raw materials consists of 3-4 parts by weight of the menthol, 1-2 parts by weight of the camphor, 3-4 parts by weight of the eucalyptus oil, 1-2 parts by weight of the perilla leaf oil, 1-2 parts by weight of the clove oil and 1-2 parts by weight of the pogostemon cablin oil.

3. The refreshing spray according to claim 1, wherein the alcoholic solvent is any one of ethanol, propylene glycol or isopropanol.

4. The refreshing spray according to claim 1, wherein the food additive is any one of jasmine essence, rose essence, sandalwood essence and lemon essence.

5. A method of making a refreshment spray, comprising the steps of: mixing 1-5 parts of menthol, 0.5-2.5 parts of camphor, 1-5 parts of eucalyptus oil, 0.5-2.5 parts of perilla leaf oil, 0.5-2.5 parts of clove oil and 0.5-2.5 parts of patchouli oil in parts by weight, and canning.

6. The method of preparing a refreshing spray according to claim 5, wherein said menthol, said camphor, said eucalyptus oil, said perilla leaf oil, said clove oil and said patchouli oil are mixed by dissolving said menthol and said camphor in an alcohol solvent and then mixing said menthol, said perilla leaf oil, said clove oil and said patchouli oil.

7. The method of preparing a refreshing spray according to claim 5, wherein said menthol, said camphor, said eucalyptus oil, said perilla leaf oil, said clove oil and said patchouli oil are mixed by dissolving said menthol and said camphor in an alcohol solvent, mixing with ice, and mixing with said eucalyptus oil, said perilla leaf oil, said clove oil and said patchouli oil.

8. The method of preparing a refreshing spray according to claim 6 or 7, further comprising filtering after mixing said menthol, said camphor, said eucalyptus oil, said perilla leaf oil, said clove oil and said patchouli oil.