CN110075293A - 氧化降低的配制剂 - Google Patents

氧化降低的配制剂 Download PDF

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Publication number
CN110075293A
CN110075293A CN201811652794.4A CN201811652794A CN110075293A CN 110075293 A CN110075293 A CN 110075293A CN 201811652794 A CN201811652794 A CN 201811652794A CN 110075293 A CN110075293 A CN 110075293A
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CN
China
Prior art keywords
oxidation
antibody
protein
antibodies
formulation
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Pending
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CN201811652794.4A
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English (en)
Chinese (zh)
Inventor
S·阿拉瓦塔姆
M·马拉尼
P·格雷瓦尔
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN110075293A publication Critical patent/CN110075293A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Lubricants (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201811652794.4A 2013-03-13 2014-03-13 氧化降低的配制剂 Pending CN110075293A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361780845P 2013-03-13 2013-03-13
US61/780,845 2013-03-13
US201361909813P 2013-11-27 2013-11-27
US61/909,813 2013-11-27
CN201480006214.8A CN104968362B (zh) 2013-03-13 2014-03-13 氧化降低的配制剂

Related Parent Applications (1)

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CN201480006214.8A Division CN104968362B (zh) 2013-03-13 2014-03-13 氧化降低的配制剂

Publications (1)

Publication Number Publication Date
CN110075293A true CN110075293A (zh) 2019-08-02

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Family Applications (2)

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CN201811652794.4A Pending CN110075293A (zh) 2013-03-13 2014-03-13 氧化降低的配制剂
CN201480006214.8A Active CN104968362B (zh) 2013-03-13 2014-03-13 氧化降低的配制剂

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EP (1) EP2968466B1 (https=)
JP (3) JP6389236B2 (https=)
KR (1) KR102237885B1 (https=)
CN (2) CN110075293A (https=)
AU (3) AU2014243700B2 (https=)
CA (2) CA2904166C (https=)
DK (1) DK2968466T3 (https=)
ES (1) ES2688895T3 (https=)
HR (1) HRP20181504T1 (https=)
HU (1) HUE039948T2 (https=)
IL (2) IL269947B (https=)
LT (1) LT2968466T (https=)
MX (2) MX369671B (https=)
MY (2) MY174679A (https=)
NZ (1) NZ711566A (https=)
PL (1) PL2968466T3 (https=)
PT (1) PT2968466T (https=)
RS (1) RS57813B1 (https=)
RU (1) RU2707092C2 (https=)
SG (2) SG11201507043SA (https=)
SI (1) SI2968466T1 (https=)
WO (1) WO2014160495A1 (https=)
ZA (2) ZA201506876B (https=)

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RU2707550C2 (ru) * 2013-03-13 2019-11-27 Дженентек, Инк. Составы со сниженным окислением
AR095398A1 (es) 2013-03-13 2015-10-14 Genentech Inc Formulaciones con oxidación reducida
AR095399A1 (es) 2013-03-13 2015-10-14 Genentech Inc Formulaciones con oxidación reducida, método
AR103173A1 (es) 2014-12-22 2017-04-19 Novarits Ag Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
WO2018002031A1 (en) 2016-06-27 2018-01-04 Morphosys Ag Anti-cd19 antibody formulations
JP7076109B2 (ja) * 2017-10-13 2022-05-27 株式会社タムラテコ 有害物処理方法およびオゾン発生装置
KR102898177B1 (ko) 2018-08-08 2025-12-10 제넨테크, 인크. 단백질 제제를 위한 트립토판 유도체 및 l-메티오닌의 용도

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CN102209554A (zh) * 2008-09-10 2011-10-05 弗·哈夫曼-拉罗切有限公司 用于防止蛋白质氧化降解的组合物和方法
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RU2015143548A (ru) 2017-04-20
JP6389236B2 (ja) 2018-09-12
LT2968466T (lt) 2018-10-10
MY174679A (en) 2020-05-06
CA2904166A1 (en) 2014-10-02
AU2014243700A1 (en) 2015-10-08
PT2968466T (pt) 2018-10-22
JP2018150317A (ja) 2018-09-27
CN104968362B (zh) 2018-12-14
RU2707092C2 (ru) 2019-11-22
AU2021201366A1 (en) 2021-03-18
MX2015011432A (es) 2016-04-27
DK2968466T3 (en) 2018-10-22
IL240933B (en) 2019-10-31
SG10201705525VA (en) 2017-08-30
MX2019013560A (es) 2020-01-20
IL269947A (https=) 2019-12-31
EP2968466B1 (en) 2018-07-25
AU2019202464A1 (en) 2019-05-02
MY199135A (en) 2023-10-17
KR20150130397A (ko) 2015-11-23
ZA201906057B (en) 2022-04-28
AU2019202464B2 (en) 2020-12-10
SI2968466T1 (sl) 2018-10-30
BR112015022484A2 (pt) 2017-07-18
IL240933A0 (en) 2015-11-30
PL2968466T3 (pl) 2018-11-30
HK1211219A1 (en) 2016-05-20
RS57813B1 (sr) 2018-12-31
IL269947B (en) 2022-08-01
EP2968466A4 (en) 2016-10-26
SG11201507043SA (en) 2015-10-29
NZ751543A (en) 2020-09-25
CA2904166C (en) 2021-05-18
ZA201506876B (en) 2019-12-18
HUE039948T2 (hu) 2019-02-28
CN104968362A (zh) 2015-10-07
JP2016520521A (ja) 2016-07-14
KR102237885B1 (ko) 2021-04-07
CA3113172A1 (en) 2014-10-02
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ES2688895T3 (es) 2018-11-07
EP2968466A1 (en) 2016-01-20
JP2020164531A (ja) 2020-10-08
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HRP20181504T1 (hr) 2018-11-02

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