KR102237885B1 - 감소된 산화를 갖는 제제 - Google Patents

감소된 산화를 갖는 제제 Download PDF

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KR102237885B1
KR102237885B1 KR1020157027940A KR20157027940A KR102237885B1 KR 102237885 B1 KR102237885 B1 KR 102237885B1 KR 1020157027940 A KR1020157027940 A KR 1020157027940A KR 20157027940 A KR20157027940 A KR 20157027940A KR 102237885 B1 KR102237885 B1 KR 102237885B1
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antibody
formulation
oxidation
compound
protein
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KR20150130397A (ko
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스리드하라 알라바탐
메리 멜라니
파비르 그레왈
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제넨테크, 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Lubricants (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020157027940A 2013-03-13 2014-03-13 감소된 산화를 갖는 제제 Active KR102237885B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361780845P 2013-03-13 2013-03-13
US61/780,845 2013-03-13
US201361909813P 2013-11-27 2013-11-27
US61/909,813 2013-11-27
PCT/US2014/026841 WO2014160495A1 (en) 2013-03-13 2014-03-13 Formulations with reduced oxidation

Publications (2)

Publication Number Publication Date
KR20150130397A KR20150130397A (ko) 2015-11-23
KR102237885B1 true KR102237885B1 (ko) 2021-04-07

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KR1020157027940A Active KR102237885B1 (ko) 2013-03-13 2014-03-13 감소된 산화를 갖는 제제

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EP (1) EP2968466B1 (https=)
JP (3) JP6389236B2 (https=)
KR (1) KR102237885B1 (https=)
CN (2) CN104968362B (https=)
AU (3) AU2014243700B2 (https=)
CA (2) CA2904166C (https=)
DK (1) DK2968466T3 (https=)
ES (1) ES2688895T3 (https=)
HR (1) HRP20181504T1 (https=)
HU (1) HUE039948T2 (https=)
IL (2) IL269947B (https=)
LT (1) LT2968466T (https=)
MX (2) MX369671B (https=)
MY (2) MY199135A (https=)
NZ (1) NZ711566A (https=)
PL (1) PL2968466T3 (https=)
PT (1) PT2968466T (https=)
RS (1) RS57813B1 (https=)
RU (1) RU2707092C2 (https=)
SG (2) SG10201705525VA (https=)
SI (1) SI2968466T1 (https=)
WO (1) WO2014160495A1 (https=)
ZA (2) ZA201506876B (https=)

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AR095398A1 (es) 2013-03-13 2015-10-14 Genentech Inc Formulaciones con oxidación reducida
US10653779B2 (en) 2013-03-13 2020-05-19 Genentech, Inc. Formulations with reduced oxidation
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AR103173A1 (es) 2014-12-22 2017-04-19 Novarits Ag Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
SI3475303T1 (sl) 2016-06-27 2021-12-31 Morphosys Ag Formulacija protitelesa proti CD19
CN111194233A (zh) * 2017-10-13 2020-05-22 株式会社田村特科 有害物质处理方法及臭氧产生装置
CA3106537A1 (en) 2018-08-08 2020-02-13 Genentech, Inc. Use of tryptophan derivatives and l-methionine for protein formulation

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Publication number Publication date
EP2968466A1 (en) 2016-01-20
SI2968466T1 (sl) 2018-10-30
ES2688895T3 (es) 2018-11-07
ZA201906057B (en) 2022-04-28
AU2014243700B2 (en) 2019-01-24
AU2014243700A1 (en) 2015-10-08
CA3113172A1 (en) 2014-10-02
IL269947A (https=) 2019-12-31
IL240933B (en) 2019-10-31
KR20150130397A (ko) 2015-11-23
ZA201506876B (en) 2019-12-18
MY174679A (en) 2020-05-06
DK2968466T3 (en) 2018-10-22
CA2904166C (en) 2021-05-18
JP2020164531A (ja) 2020-10-08
AU2019202464A1 (en) 2019-05-02
CA2904166A1 (en) 2014-10-02
CN104968362B (zh) 2018-12-14
MX369671B (es) 2019-11-15
RS57813B1 (sr) 2018-12-31
JP2016520521A (ja) 2016-07-14
EP2968466B1 (en) 2018-07-25
MX2015011432A (es) 2016-04-27
SG10201705525VA (en) 2017-08-30
PT2968466T (pt) 2018-10-22
PL2968466T3 (pl) 2018-11-30
CN104968362A (zh) 2015-10-07
IL240933A0 (en) 2015-11-30
MX2019013560A (es) 2020-01-20
WO2014160495A1 (en) 2014-10-02
LT2968466T (lt) 2018-10-10
IL269947B (en) 2022-08-01
BR112015022484A2 (pt) 2017-07-18
HUE039948T2 (hu) 2019-02-28
HK1211219A1 (en) 2016-05-20
NZ751543A (en) 2020-09-25
MY199135A (en) 2023-10-17
AU2019202464B2 (en) 2020-12-10
JP2018150317A (ja) 2018-09-27
RU2707092C2 (ru) 2019-11-22
RU2015143548A (ru) 2017-04-20
HRP20181504T1 (hr) 2018-11-02
NZ711566A (en) 2020-06-26
AU2021201366A1 (en) 2021-03-18
CN110075293A (zh) 2019-08-02
SG11201507043SA (en) 2015-10-29
JP6389236B2 (ja) 2018-09-12
EP2968466A4 (en) 2016-10-26

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