CN109991431A - Sample analyser and its agent delivery method - Google Patents
Sample analyser and its agent delivery method Download PDFInfo
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- CN109991431A CN109991431A CN201811521942.9A CN201811521942A CN109991431A CN 109991431 A CN109991431 A CN 109991431A CN 201811521942 A CN201811521942 A CN 201811521942A CN 109991431 A CN109991431 A CN 109991431A
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- 238000002716 delivery method Methods 0.000 title claims abstract description 26
- 239000007788 liquid Substances 0.000 claims abstract description 350
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 255
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 95
- 238000006243 chemical reaction Methods 0.000 claims abstract description 78
- 238000001514 detection method Methods 0.000 claims abstract description 27
- 239000012085 test solution Substances 0.000 claims abstract description 12
- 238000012546 transfer Methods 0.000 claims description 36
- 239000002699 waste material Substances 0.000 claims description 35
- 238000006073 displacement reaction Methods 0.000 claims description 18
- 230000008030 elimination Effects 0.000 claims description 5
- 238000003379 elimination reaction Methods 0.000 claims description 5
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 description 54
- 238000010586 diagram Methods 0.000 description 14
- 239000012530 fluid Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 238000004458 analytical method Methods 0.000 description 7
- 239000003219 hemolytic agent Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- 239000012472 biological sample Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000001502 supplementing effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 210000003924 normoblast Anatomy 0.000 description 1
- 238000011897 real-time detection Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The application discloses a kind of sample analyser, including sampler, agent delivery device, at least one reaction unit and at least one detection device, sampler acquires a sample to be tested and at least portion of sample to be tested is transferred at least one reaction unit, agent delivery device includes liquid storage tank at least one machine, liquid storage tank draws reagent outside a machine by power source to carry out charging operation to liquid storage tank in machine in each machine in reagent barrel, and the reagent in liquid storage tank in machine is transferred to the reaction unit being connected to liquid storage tank in machine, sample to be tested and reagent hybrid reaction in each reaction unit obtain test solution, detection device detects test solution and generates detection information.A kind of agent delivery method of sample analyser is also disclosed in the application.By liquid storage tank in machine, reagent barrel draws reagent to the application from the outside, replaces when novel agent bucket that reagent residue amount is low in old reagent barrel, and the time for replacing novel agent bucket is short, and reagent consumption is few when replacing novel agent bucket.
Description
Technical field
This application involves biological sample analysis field more particularly to a kind of sample analyser and its agent delivery methods.
Background technique
With the development of science and technology, it is quality-high and inexpensive not to be intended merely to product by people, it is also desirable to product in use its
The lower use cost the better.For example, sample analyser reagent residue amount in old reagent barrel when replacing novel agent bucket, more renews examination
The time of agent bucket, reagent consumption etc. all directly affects the use cost of sample analyser when replacing novel agent bucket.However, existing
Reagent residue amount is more in old reagent barrel when replacing novel agent bucket for some sample analysers, and the time for replacing novel agent bucket is long, more
Reagent consumption is more when renewing reagent barrel, and use cost is high.
Summary of the invention
The application embodiment discloses a kind of sample analyser and its agent delivery method, to solve the above problems.
A kind of sample analyser disclosed in the application embodiment, including sampler, agent delivery device, at least one
Reaction unit and at least one detection device, the sampler for acquire a sample to be tested and by the sample to be tested extremely
Few portion is transferred at least one described reaction unit, and the agent delivery device includes liquid storage tank at least one machine, each
Liquid storage tank draws reagent outside a machine by power source to carry out charging operation to liquid storage tank in the machine in machine in reagent barrel,
And the reagent in liquid storage tank in the machine is transferred to the reaction unit being connected to liquid storage tank in the machine, it is each described anti-
Sample to be tested and the reagent hybrid reaction in device is answered to obtain test solution, the detection device is detected and generated to the test solution
Detection information.
A kind of agent delivery method of sample analyser disclosed in the application embodiment, comprising steps of providing one has
Liquid storage tank in the machine of reagent is formed between reagent barrel outside liquid storage tank and the machine being connected with liquid storage tank in the machine in the machine close
Close space；A reagent transfer device is provided, reagent transfer device liquid storage tank out of described machine delivers reagents into the machine
While the reaction unit of interior liquid storage tank connection, negative pressure is formed in the confined space；And the negative pressure promotes storage in the machine
Liquid pool draws reagent from the reagent barrel to replenish in the machine in liquid storage tank.
Reagent barrel draws reagent, replacement to the agent delivery method of the sample analyser of the application and sample analyser from the outside
The time of novel agent bucket is short, and reagent consumption is few when replacing novel agent bucket, and reagent residue amount is low in old reagent barrel.
Detailed description of the invention
In order to illustrate more clearly of the technical solution in the application embodiment, will make below to required in embodiment
Attached drawing is briefly described, it should be apparent that, the accompanying drawings in the following description is only some embodiments of the application, right
For those of ordinary skill in the art, without creative efforts, it can also be obtained according to these attached drawings
His attached drawing.
Fig. 1 is the module diagram of the sample analyser in one embodiment of the application.
Fig. 2 is the fluid path schematic diagram of the agent delivery device and reaction unit in the application first embodiment.
Fig. 3 is the fluid path schematic diagram of the agent delivery device and reaction unit in the application second embodiment.
Fig. 4 is the fluid path schematic diagram of the agent delivery device and reaction unit in the application third embodiment.
Fig. 5 is the fluid path schematic diagram of the agent delivery device and reaction unit in the 4th embodiment of the application.
Fig. 6 is the flow diagram of the agent delivery method of the sample analyser in the application first embodiment.
Fig. 7 is the flow diagram of the agent delivery method of the sample analyser in the application second embodiment.
Specific embodiment
Below in conjunction with the attached drawing in the application embodiment, the technical solution in the application embodiment is carried out clear
Chu is fully described by, it is clear that described embodiment is only a part of embodiment of the application, rather than whole implementation
Mode.Based on the embodiment in the application, those of ordinary skill in the art are obtained without making creative work
The every other embodiment obtained, shall fall in the protection scope of this application.
Referring to Fig. 1, Fig. 1 is the module diagram of the sample analyser 100 in one embodiment of the application.The sample
Analyzer 100 is used to carry out medical analysis to sample to be tested and generates corresponding detection information.It is described to be measured in present embodiment
Sample is blood sample.It is understood that in other embodiments, the sample to be tested can also be body fluid sample, serum sample,
Plasma sample, urine specimen or other suitable biological sample, herein with no restrictions.Specifically, the sample analyser 100 wraps
Include sampler 10, agent delivery device 30, at least one reaction unit 50 and at least one detection device 70.The sampling dress
Set 10 for acquire a sample to be tested (not shown) and by at least portion of the sample to be tested be transferred to it is described at least one instead
Answer device 50.It is understood that in the present embodiment, the sample to be tested can be divided into more parts by the sampler 100, and will be every
Part sample to be tested is transferred to the corresponding reaction unit 50.In other embodiments, every part of sample to be tested can pass through
The mode of needle tubing injection is transferred to the corresponding reaction unit 50.
Please also refer to the agent delivery device 30 and reaction unit 50 that Fig. 2, Fig. 2 are in the application first embodiment
Fluid path schematic diagram.The agent delivery device 30 includes liquid storage tank 31 and power source 32 at least one machine.The power source 32
It is connected to respectively with liquid storage tank 31 in each machine.In present embodiment, the power source 32 is high-pressure pump, can be generated
Negative pressure.Liquid storage tank 31 draws reagent outside a machine by the power source 32 to carry out to institute in each machine in reagent barrel 33
The reagent for stating liquid storage tank 31 in machine charges operation.Wherein, the reagent includes but is not limited to: hemoglobinometry hemolytic agent,
Leukocyte analysis hemolytic agent, erythroblast analysis hemolytic agent and granulophilocyte analysis dilution etc..The reagent
Any one reagent can be filled as needed in bucket 33." the charging ", which refers to, fills liquid storage tank 31 in the machine with reagent.
During the progress of liquid storage tank 31 reagent charges in the machine, the air of liquid storage tank 31 is along liquid storage tank in the machine in the machine
Flow path discharge between 31 and the power source 32, therefore it is not required to additional special exhaust bubble step.
Specifically, the capacity of liquid storage tank 31 is smaller in each machine, is no more than 100 milliliters, liquid storage tank 31 in the machine
Low capacity make liquid storage tank 31 in the machine charge that speed is fast, in the replacement one new examination for filling reagent full of reagent
After agent bucket 33, supplementing the time that the liquid measure is consumed only is needed several seconds, it is fast that replacement reagent speed may be implemented, it is possible to reduce the sample
The stand-by time of analyzer 100 improves working efficiency, more efficient service is provided for client.
Specifically, the sample analyser 100 includes board (not shown), and the board has an accommodating space, and (figure is not
Show), liquid storage tank 31 is arranged in the accommodating space in the machine.
It preferably, can be by the reagent barrel in order to reduce or be discharged the bubble in agent delivery device pipeline as far as possible
33 are placed on the ground outside the board, and the level height of the position of liquid storage tank 31 is higher than the reagent barrel 33 in the machine
And it is lower than the reaction unit 50.It in other embodiments, can also be by the receiving in order to facilitate the arrangement of machine inner assembly
The top of the board is arranged in space.
Reagent in each machine in liquid storage tank 31 is transferred to the reaction unit being connected to liquid storage tank 31 in the machine
50.Sample to be tested and reagent hybrid reaction in each reaction unit 50 obtain test solution.The detection device 70 is to described
Test solution is detected and generates detection information.
Specifically, liquid storage tank 31 and at least one described reaction unit 50 one-to-one correspondence are connected to and set at least one described machine
It sets.Liquid storage tank 31 is that the corresponding reaction unit 50 provides reagent in each machine.
Specifically, at least one described reaction unit 50 and at least one described detection device 70 are arranged in a one-to-one correspondence.Often
A reaction unit 50 is that the corresponding detection device 70 provides test solution, so that the detection device 70 carries out test solution detection
And generate corresponding detection information.
Specifically, liquid storage tank 31 is connected with the corresponding reagent barrel 33 in each machine, moreover, each machine
Interior liquid storage tank 31 is without valve but is directly connected with the corresponding reagent barrel 33.
Specifically, the reagent of liquid storage tank 31 is transferred to and described the reacting of the connection of liquid storage tank 31 in the machine in each machine
During device 50, confined space is formed between liquid storage tank 31 and the corresponding reagent barrel 33 in the machine.
Wherein, the confined space is the confined space of normal pressure." normal pressure " refers in the machine in liquid storage tank 31
Pressure is held essentially constant, and only when supplying reagent to the corresponding reaction unit 50, dynamic generates of short duration negative pressure, and
The negative pressure adds in the machine after the reagent in the reagent barrel 33 just to disappear after liquid storage tank 31.
Specifically, liquid storage tank 31 is supplied to the reaction unit 50 being connected to liquid storage tank 31 in the machine every time in the machine
After answering reagent, the negative pressure formed between liquid storage tank 31 and the reaction unit 50 in the machine promote in the machine liquid storage tank 31 from
The reagent barrel 33 draws reagent to replenish in the machine in liquid storage tank 31.
Specifically, the agent delivery device 30 further includes at least one constant displacement pump 312, and each setting of constant displacement pump 312 exists
In the corresponding machine between liquid storage tank 31 and the reaction unit 50 being connect with liquid storage tank 31 in the machine, the constant displacement pump
312 out of described machine liquid storage tank 31 draw quantitative reagent and be transferred to and described reacted with what liquid storage tank 31 in the machine was connected
Device 50.Further specifically, pass through three in the machine between liquid storage tank 31, the constant displacement pump 312 and the reaction unit 50
Port valve 313 connects.The constant displacement pump 312 is connect by triple valve 314 with negative pressure power source 3151 and positive pressure power source 3152.Institute
Stating negative pressure power source 3151 promotes the constant displacement pump 312 liquid storage tank 31 out of described machine to draw reagent.The positive pressure power source
3152 promote the constant displacement pump 312 to deliver reagents into the reaction unit 50.Preferably, the horizontal height of the position of constant displacement pump
Higher than liquid storage tank 31 in the machine and it is lower than the reaction unit 20.
Specifically, the constant displacement pump 312 is when liquid storage tank 31 draws the quantitative reagent out of described machine, storage in the machine
The confined space that liquid pool 31 is connected and is formed with the reagent barrel 33, in the machine liquid storage tank 31 every time to stored up in the machine
After the reaction unit 50 that liquid pool 31 is connected to supplies the quantitative reagent, liquid storage tank 31 and the reagent barrel 33 in the machine
Between the negative pressure that is formed promote in the machine liquid storage tank 31 to draw the quantitative reagent from the reagent barrel 33 to supplement
In the machine in liquid storage tank 31.
To which liquid storage tank 31 is added into the reaction unit 50 connecting with liquid storage tank 31 in the machine in the machine
When after reagent, certain negative pressure is formed in the machine in liquid storage tank 31, the negative pressure promotes automatic from 33 inside of reagent barrel
The reagent of consumption is supplemented, the sample analyser 100 carries out being not necessarily to additionally recharge storage in the machine during sample analysis
Liquid pool 31 can save the system air consumption in measurement process.
Specifically, the agent delivery device 30 further includes controller 310 and at least one first control valve 34, Mei Gesuo
Liquid storage tank 31 in machine is stated to connect by corresponding first control valve 34 with the power source 32.
The controller 310 controls at least one described first control valve 34 and opens with to right with first control valve 34
Liquid storage tank 31 charges reagent in the machine answered.Specifically, first control valve 34 open when, the power source 32 with it is described
It is connected between liquid storage tank 31 in machine.Therefore, it is possible to by the power source 32 to described in being connect with first control valve 34
Liquid storage tank 31 charges reagent in machine.
The controller 310 controls at least one described first control valve 34 and closes to stop the liquid storage tank 31 into the machine
Charge reagent.Specifically, when first control valve 34 is closed, do not connect between liquid storage tank 31 in the power source 32 and the machine
It is logical.Thus, it is not possible to liquid storage tank 31 in the machine connecting with first control valve 34 is charged by the power source 32
Reagent.
It is understood that in present embodiment, in the quantity of at least one first control valve 34 and at least one described machine
The quantity of liquid storage tank 31 is identical, at least one described first control valve 34 is corresponded with liquid storage tank 31 at least one described machine
Connection setting, at least one described first control valve 34 are connect with the power source 32 respectively.To at least one described machine
Liquid storage tank 31 can be respectively adopted the different pressure progress reagents that charges and charge operation, also, liquid storage tank 31 can in each machine
Complete independently charges operation, is not influenced by liquid storage tank 31 in machine described in other.
Specifically, the agent delivery device 30 further includes at least one level sensor 35.It is described in present embodiment
Level sensor 35 is float.The float is mobile with liquid level, and can be with real-time detection liquid level to obtain liquid level information.It can
Understand, in other embodiments, the level sensor 35 includes at least two pieces of level plates, the corresponding need of each level plate
The liquid level to be monitored.Level plate is connect by connecting rod with sensor, and whether liquid level reaches target liquid level, can generate two kinds of electricity
Signal generates liquid level information.
At least one described level sensor 35 is correspondingly arranged with liquid storage tank 31 at least one described machine.Wherein, each
At least one described level sensor 35 is set in liquid storage tank 31 in the machine, and the controller 310 is in the level sensor
35 when sensing the first liquid level, control the closing of first control valve 34 corresponding with the level sensor 35 with stop to
Liquid storage tank 31 charges reagent in the corresponding machine of the level sensor 35, and the controller 310 is in the level sensor
35 when sensing the second liquid level, controls the agent delivery device 30 and stops providing reagent to the reaction unit 50.Wherein, originally
In embodiment, first liquid level is high liquid level, and second liquid level is low liquid level.
Specifically, the controller 310 controls the agent delivery device 30 and stops providing examination to the reaction unit 50
After agent, generate without reagent fault message.When user's replacement fills the novel agent bucket 33 of reagent and in the sample analyser 100
After point disappears failure in user interface, the controller 310 controls first control valve corresponding with the level sensor 35
34 open, to transfer liquid storage tank 31 in reagent to the machine out of novel agent bucket 33 under the driving of the power source 32.It is described
Controller 310 controls corresponding with the level sensor 35 described when the level sensor 35 senses the first liquid level
First control valve 34 is closed to stop charging.
Specifically, the difference in height in the machine between the first liquid level and the second liquid level of liquid storage tank 31 is smaller, thus due to
It is completely to arrive the level sensor 35 to detect liquid storage tank in the machine that the level sensor 35, which detects liquid storage tank 31 in the machine,
31 be empty process, and the liquid level decline of liquid storage tank 31 is smaller in the machine, after one novel agent bucket 33 full of reagent of replacement,
Supplementing the time that the liquid measure is consumed only needs several seconds, and it is fast to may be implemented replacement reagent speed, can be further reduced the sample point
The stand-by time of analyzer 100 improves working efficiency, more efficient service is provided for client.
Specifically, the controller 310 is issued when the level sensor 35 senses third liquid level without reagent failure
Information, while the reagent in the machine in liquid storage tank 31 is persistently transferred to the reaction connecting with liquid storage tank 31 in the machine
Device 50.When the novel agent bucket 33 of reagent is filled in user's replacement and puts the event that disappears in the user interface of the sample analyser 100
After barrier, the controller 310 control first control valve 34 be connected in the power source 32 and the machine liquid storage tank 31 with
Liquid storage tank 31 in reagent to the machine, and institute during charging are transferred under the driving of the power source 32 out of novel agent bucket 33
It states the reagent in machine in liquid storage tank 31 and is persistently transferred to the reaction unit 50 connecting with liquid storage tank 31 in the machine.Its
In, the third liquid level is an early warning liquid level, between first liquid level and second liquid level.To institute's sample
Analyzer 100 is generated without reagent fault message, when the level sensor 35 senses third liquid level to provide user's replacement
Novel agent bucket 33 simultaneously executes and charges operation again, and generates without reagent fault message to during charging operation again, institute
The reagent for stating liquid storage tank 31 in machine is constantly provided the reaction unit 50 connecting with liquid storage tank 31 in the machine, realizes
Replacement reagent is not shut down, saves the time for user, there is better user experience.
Specifically, the power source 32 be charge again the negative pressure provided absolute value be less than the constant displacement pump 312 will examination
Agent liquid storage tank 31 out of described machine is transferred to the pressure absolute value of the reaction unit 50.It is understood that in one embodiment, it can
It is to charge to provide negative pressure again by lower negative pressure air pump set in addition.It in another embodiment, can be by set in addition
Reagent in the reagent barrel 33 is transplanted in the machine in liquid storage tank 31 by constant displacement pump or syringe repeatedly.
Specifically, the controller 310 controls first control valve 34 and is connected to storage in the power source 32 and the machine
After the execution of liquid pool 31 charges preset time period, when the level sensor 35 is still without most the first liquid level is sensed, described in control
Agent delivery device 30 stops providing reagent to the reaction unit 50.
To which using 35 detection reagent of the level sensor in liquid storage tank 31 in the machine, whether there is or not when liquid level declines
When to the level sensor 35 and generating trigger signal, generate without reagent fault message, at this point, the examination in the reagent barrel 33
Agent has been drawn into the greatest extent in the machine in liquid storage tank 31, and the reagent residue amount in the reagent barrel 33 is low.Replacement is full of
After the novel agent bucket 33 of reagent, using the power source 32, the reagent in the reagent barrel 33 is charged into liquid storage in the machine
Pond 31 then replaces reagent success, during this, the sample point when the level sensor 35 floats and generates trigger signal
Analyzer 100 does not consume reagent, and replacement reagent is in the process without reagent waste.
It is the agent delivery device 30a and reaction unit 50 in the application second embodiment please also refer to Fig. 3, Fig. 3
Fluid path schematic diagram.The agent delivery device 30a is similar to the agent delivery device 30, and difference place is, the examination
The power source 32a of agent feeding mechanism 30a is small air pump, described stingy unlike the high-pressure pump in first embodiment
Pump it is at low cost, can also be used to generate charge reagent needs negative pressure, but the high-pressure pump can not only generate charge reagent need
The negative pressure wanted, moreover it is possible to generate positive pressure, be used as other purposes.
It is the agent delivery device 30b and reaction unit 50 in the application third embodiment please also refer to Fig. 4, Fig. 4
Fluid path schematic diagram.The agent delivery device 30b is similar to the agent delivery device 30, and difference place is, the examination
Agent feeding mechanism 30b further includes waste liquid pool 36, third control valve 38 and waste liquid barrel 39.The waste liquid pool 36 collects the reaction dress
The test solution of 50 and the detection device 70 is set, the waste liquid barrel 39 is connect with the waste liquid pool 36, and the setting of waste liquid pool 36 exists
In at least one described machine between liquid storage tank 31 and the power source 32, the third control valve 38 is arranged in the waste liquid pool 36
Between the power source 32.The power source 32 is high-pressure pump, can provide positive pressure, can also provide negative pressure.It is described
When third control valve 38 is opened, the power source 32 provides positive pressure to the waste liquid pool 36 to empty the waste liquid of waste liquid pool 36 to institute
It states in waste liquid barrel 39, the power source 32 provides negative pressure to the waste liquid pool 36 to collect waste liquid to the waste liquid pool 36.It is described
Waste liquid pool 36 is also connect by the first control valve 34 with liquid storage tank 31 in the machine, when liquid storage tank 31 needs to charge in machine, is beaten
The first control valve 34 is opened, waste liquid pool 36 is that liquid storage tank 31 provides negative pressure in machine, so that described in the reagent entrance of the reagent barrel 33
Liquid storage tank 31 in machine.
It is understood that in other embodiments, the third control valve 38 can be omitted, the power source 32 directly with it is described
Waste liquid pool 36 connects.
It is understood that when user's replacement fills the novel agent bucket 33 of reagent and in the user interface of the sample analyser 100
Upper point disappears after failure, and the negative pressure absolute value for reconciling the waste liquid pool 36 is less than the constant displacement pump 312 31 pond of liquid storage out of described machine
The pressure for drawing reagent does not influence the constant displacement pump 312 and works, and the reagent of the reagent barrel 33 is allowed to enter liquid storage tank in the machine
31, when the level sensor 35 senses first liquid level, charge completion.
The power source 32 for charging liquid storage tank 31 in the machine is received using the sample analyser 100 for other channel waste liquids
The waste liquid pool 36 of collection, its advantage is that when the level sensor 35 has exception accurately not detect liquid level, liquid storage in the machine
Reagent inside pond 31 may flow backward into gas circuit, and after the waste liquid pool 36, reagent can be in the waste liquid pool 36
The gas source cached without entering instrument damages the sample analyser.
After replacement is full of the novel agent bucket 33 of reagent, using the power source 32 in the waste liquid pool 36, by the examination
Reagent in agent bucket 33 charges liquid storage tank 31 in the machine, after the level sensor 35 floats and generates trigger signal then
Reagent success is replaced, during this, the sample analyser 100 does not consume reagent, without reagent waste during replacement reagent.
It is the agent delivery device 30c and reaction unit 50 in the 4th embodiment of the application please also refer to Fig. 5, Fig. 5
Fluid path schematic diagram.The agent delivery device 30c is similar to the agent delivery device 30b, and difference place is, the examination
Agent feeding mechanism further includes at least one the first control valve 34 and at least one second control valve 37, at least one described first control
Valve 34 processed is identical as first embodiment, and details are not described herein again, the setting of described at least one second control valve 37 it is described extremely
On the flow path connected between liquid storage tank 31 and at least one described reagent barrel 33 in a few machine, at least one described second control
The execution of liquid storage tank 31 in the machine of valve 37 charges reagent and makes the machine during supplying reagent to the reaction unit 50
Interior liquid storage tank 31 is connected to the reagent barrel 33, the emptying of liquid storage tank 31 examination in the machine of at least one described second control valve 37
Atmosphere is connected to when agent is to be overhauled.
Specifically, it is corresponded between liquid storage tank 31 at least one described second control valve 37 and at least one described machine
It connects, connects one to one between liquid storage tank 31 at least one described second control valve 37 and at least one described machine.
Increasing by second control valve 37 in the reagent barrel 33 and the machine between liquid storage tank 31, is being advantageous in that, is
The needs of maintenance etc., without by the bottle cap component (figure of the reagent barrel 33 when need to empty the reagent of liquid storage tank 31 in the machine
Do not show) put forward from the reagent barrel 33 to connect atmosphere, but second control valve 37 is switched on atmosphere,
Operation convenient to overhaul.
Fig. 6 is the flow diagram of the agent delivery method of the sample analyser 100 in the application first embodiment.Institute
Agent delivery method is stated applied in sample analyser 100 above-mentioned, execution sequence is not limited to sequence shown in fig. 6.It is described
Method comprising steps of
Step 610: liquid storage tank 31 in a machine with reagent is provided, in the machine liquid storage tank 31 and with liquid storage in the machine
Confined space is formed between the outer reagent barrel 33 of the connected machine in pond 31.Specifically, the confined space is the confined space of normal pressure.
Step 620: providing a reagent transfer device, reagent transfer device liquid storage tank 31 out of described machine moves reagent
While being sent to reaction unit 50 that liquid storage tank 31 is connected in the machine, negative pressure is formed in the confined space.Wherein, the examination
Agent transfer device can be constant displacement pump 312, syringe etc..
Step 630: the negative pressure promotes in the machine liquid storage tank 31 to draw reagent from the reagent barrel 33 to replenish
It states in machine in liquid storage tank 31.
Specifically, the reagent transfer device is transplanted on the amount of the reagent of liquid storage tank 31 in the machine every time and supplements every time
The amount of the reagent of liquid storage tank 31 is equal in the machine.
Selectively, the agent delivery method further comprises the steps of:
Step 640: obtaining the liquid level information of the reagent of liquid storage tank 31 in the machine.Specifically, the controller 310 passes through
The level sensor 35 obtains the liquid level information of the reagent of liquid storage tank 31 in the machine.
Step 650: when judging that the liquid level is in the second liquid level, controlling the reagent transfer device stopping movement.Specifically
Ground when the controller 310 judges that the liquid level is in second liquid level, controls the reagent transfer device stopping movement.
Wherein, low liquid level when second liquid level.
Selectively, the agent delivery method further comprises the steps of:
Step 660: the reagent transfer device stopping movement being generated without reagent fault message.Specifically, the controller
The 310 controls reagent transfer device stopping movement, generates without reagent fault message, and control the sample analyser 100
The no reagent fault message is shown in user interface.
Step 670: after obtaining Failure elimination information, liquid storage tank 31 is under the driving of the power source 32 from one in the machine
Liquid storage tank 31 in transfer reagent to the machine in the outer reagent barrel 33 of machine.
Specifically, after point of the response of controller 310 user in the user interface disappears failed operation, failure is obtained
Information is eliminated, and controls liquid storage tank 31 in the machine and transfers reagent out of described reagent barrel 33 under the driving of the power source 32
Liquid storage tank 31 in the machine.
Step 680: obtaining the liquid level information of the reagent of liquid storage tank 31 in the machine, judge that the liquid level is in the first liquid level
When, stop reagent transfer.Specifically, the controller 310 obtains liquid storage tank 31 in the machine by the level sensor 35
Reagent liquid level information when, judge that the liquid level is in the first liquid level, that is, when high liquid level, control first control valve
34 closings charge reagent to stop the liquid storage tank 31 into the machine.
In the present embodiment, liquid storage tank 31 is to provide reagent in the reaction unit 50 connected to it in the machine
Afterwards, certain negative pressure is formed in the machine in liquid storage tank 31, the negative pressure promotes to be automatically replenished inside the reagent barrel 33 and disappear
The reagent of consumption, the sample analyser 100 carry out being not necessarily to additionally recharge liquid storage tank 31 in the machine during sample analysis,
The system air consumption in measurement process can be saved.In addition, agent delivery device can stop in the first liquid level to the machine
Interior liquid storage tank 31 charges reagent, and the reagent transfer device stopping movement being controlled in the second liquid level, can on the one hand avoid
In the machine on the other hand liquid storage tank 31 avoids hypovolia that bubble is caused to enter the machine due to hypervolia reverse irrigation air inlet path
Fluid path between interior liquid storage tank 31 and the reaction unit 50.The sample analyser 100 of the present embodiment mode has and is arranged in instrument
Liquid storage tank 31 in the machine of small volume inside device charges liquid storage in machine first by the reagent of reagent barrel 33 outside machine, such as hemolytic agent
Then pond 31 makes liquid storage tank 31 and the outer reagent barrel 33 of machine in machine form pressure balanced confined space, utilizes liquid storage tank in machine
The of short duration negative pressure that 31 transfer reagents are generated to reaction unit 50 makes the reagent of reagent barrel 33 outside machine that liquid storage in machine be replenished in time
Pond 31 can make full use of reagent, and shorten the time that instrument caused by reagent is replaced stops working, and improve test speed.
Fig. 7 is the flow diagram of the agent delivery method of the sample analyser 100 in the application second embodiment.Institute
Agent delivery method is stated applied in sample analyser 100 above-mentioned, execution sequence is not limited to sequence shown in Fig. 7.It is described
Method comprising steps of
Step 710: liquid storage tank 31 in a machine with reagent is provided, in the machine liquid storage tank 31 and with liquid storage in the machine
Confined space is formed between the outer reagent barrel 33 of the connected machine in pond 31.Specifically, the confined space is the confined space of normal pressure.
Step 720: providing a reagent transfer device, reagent transfer device liquid storage tank 31 out of described machine moves reagent
While being sent to reaction unit 50 that liquid storage tank 31 is connected in the machine, negative pressure is formed in the confined space.
Step 730: the negative pressure promotes in the machine liquid storage tank 31 to draw reagent from the reagent barrel 33 to replenish
It states in machine in liquid storage tank 31.
Specifically, the reagent transfer device is transplanted on the amount of the reagent of liquid storage tank 31 in the machine every time and supplements every time
The amount of the reagent of liquid storage tank 31 is equal in the machine.
Selectively, the agent delivery method further comprises the steps of:
Step 740: obtaining the liquid level information of the reagent of liquid storage tank 31 in the machine.Specifically, the controller 310 passes through
The level sensor 35 obtains the liquid level information of the reagent of liquid storage tank 31 in the machine.
Step 750: when judging that the liquid level is in third liquid level, generating without reagent fault message, while the reagent moves
Device is sent still to need liquid storage tank in slave to transfer reagent to the reaction unit connecting with liquid storage tank in the machine according to detection
50.Specifically, the controller 310 is believed by the liquid level that the level sensor 35 obtains the reagent of liquid storage tank 31 in the machine
Breath when judging that the liquid level is in third liquid level i.e. early warning liquid level, is generated without reagent fault message, while the reagent moves
Device is sent still to need to transfer reagent to the reaction unit 50 connecting with liquid storage tank 31 in the machine according to detection.
Step 760: after obtaining Failure elimination information, liquid storage tank 31 is under the driving of the power source 32 from one in the machine
Liquid storage tank 31 is charged in transfer reagent to the machine in the outer reagent barrel 33 of machine, and during charging, liquid storage in the machine
Reagent in pond 31 still needs to be transferred to the reaction unit 50 connecting with liquid storage tank 31 in the machine according to detection.Specifically
Ground, point of the response of controller 310 user in the user interface disappear after failed operation, obtain Failure elimination information, and
Liquid storage tank 31 in the machine is controlled to transfer in reagent to the machine out of described reagent barrel 33 under the driving of the power source 32
Liquid storage tank 31 is charged, and during charging, and the reagent in the machine in liquid storage tank 31 still needs to be transferred to according to detection
The reaction unit 50 being connect with liquid storage tank 31 in the machine.
Step 770: sensing that the liquid level in the machine in liquid storage tank 31 is in the first liquid level in the level sensor 35
When, stop reagent transfer.Specifically, the controller 310 senses liquid storage tank 31 in the machine in the level sensor 35
When interior liquid level is in the first liquid level, i.e. high liquid level, stop reagent transfer.
In the present embodiment, institute's sample analyser 100 is generated when the level sensor 35 senses third liquid level
Without reagent fault message, operation is charged again to provide user's replacement novel agent bucket 33 and execute, and generate without reagent failure
Information is to during charging operation again, and the reagent of liquid storage tank 31 is constantly provided and liquid storage tank in the machine in the machine
The reaction unit 50 of 31 connections, realizes and does not shut down replacement reagent, saves the time for user, has better user's body
It tests.
It should be noted that for simple description, therefore, it is stated as a systems for each embodiment of the method above-mentioned
The combination of actions of column, but those skilled in the art should understand that, the application is not limited by the described action sequence, because
For according to the application, certain some step be can be performed in other orders or simultaneously.Secondly, those skilled in the art also should
Know, the embodiments described in the specification are all preferred embodiments, related actions and modules not necessarily this Shen
It please be necessary.
In the above-described embodiments, it all emphasizes particularly on different fields to the description of each embodiment, is not described in some embodiment
Part, reference can be made to the related descriptions of other embodiments.
Step in the embodiment of the present application method can be sequentially adjusted, merged and deleted according to actual needs.
The above is the preferred embodiment of the application, it is noted that for those skilled in the art
For, under the premise of not departing from the application principle, several improvements and modifications can also be made, these improvements and modifications are also considered as
The protection scope of the application.
Claims (22)
1. a kind of sample analyser, including sampler, agent delivery device, at least one reaction unit and at least one detection
Device, the sampler is for acquiring a sample to be tested and at least portion of the sample to be tested being transferred to described at least one
A reaction unit, the agent delivery device include liquid storage tank at least one machine, in each machine liquid storage tank by power source from
Reagent is drawn in the outer reagent barrel of one machine to carry out charging operation to liquid storage tank in the machine, and will be in liquid storage tank in the machine
Reagent is transferred to the reaction unit being connected to liquid storage tank in the machine, sample to be tested and examination in each reaction unit
Agent hybrid reaction obtains test solution, and the detection device detects the test solution and generates detection information.
2. sample analyser as described in claim 1, which is characterized in that at least one described machine liquid storage tank and it is described at least
One reaction unit corresponds connection setting, and liquid storage tank provides reagent for the corresponding reaction unit in each machine.
3. sample analyser as described in claim 1, which is characterized in that the reagent of liquid storage tank is transferred in each machine
During the reaction unit being connected to liquid storage tank in the machine, formed between liquid storage tank and the reagent barrel in the machine
Confined space.
4. sample analyser as claimed in claim 3, which is characterized in that in the machine liquid storage tank every time to stored up in the machine
After the reaction unit supply reagent of liquid pool connection, the negative pressure formed between liquid storage tank and the reaction unit in the machine promotees
Liquid storage tank is set in the machine to draw reagent from the reagent barrel to replenish in the machine in liquid storage tank.
5. such as the described in any item sample analysers of Claims 1-4, which is characterized in that the agent delivery device further includes
Liquid storage tank and the institute connecting with liquid storage tank in the machine in the corresponding machine is arranged at least one constant displacement pump, each constant displacement pump
It states between reaction unit, constant displacement pump liquid storage tank out of described machine is drawn quantitative reagent and is transferred to and liquid storage in the machine
The reaction unit that pond is connected.
6. sample analyser as claimed in claim 5, which is characterized in that it is fixed that constant displacement pump liquid storage tank out of described machine is drawn
When the reagent of amount, liquid storage tank is connected with the reagent barrel in the machine, in the machine liquid storage tank every time to the machine
After the reaction unit of interior liquid storage tank connection supplies the quantitative reagent, in the machine between liquid storage tank and the reagent barrel
The negative pressure of formation promotes in the machine liquid storage tank to draw the quantitative reagent from the reagent barrel to replenish the machine
In interior liquid storage tank.
7. sample analyser as described in claim 1, which is characterized in that in the machine liquid storage tank without valve directly with it is described
Reagent barrel is connected.
8. sample analyser as described in claim 1, which is characterized in that the agent delivery device further includes controller and extremely
Lacking first control valve, liquid storage tank is connect by corresponding first control valve with the power source in each machine,
The power source provides negative pressure, and the controller controls at least one described first control valve and opens to control to described first
Liquid storage tank charges reagent in the corresponding machine of valve, and the controller controls at least one described first control valve and closes to stop
Into the machine, liquid storage tank charges reagent.
9. sample analyser as claimed in claim 8, which is characterized in that the quantity of at least one first control valve and institute
The quantity for stating liquid storage tank at least one machine is identical, liquid storage tank at least one described first control valve and at least one described machine
It connects one to one, at least one described first control valve is connect with the power source respectively.
10. such as the described in any item sample analysers of claim 8 to 9, which is characterized in that the agent delivery device further includes
At least one second control valve, described at least one second control valve be arranged at least one described machine liquid storage tank and it is described extremely
On the flow path connected between a few reagent barrel, the liquid storage tank execution in the machine of at least one described second control valve charges examination
Agent with supply reagent to the reaction unit during be connected to liquid storage tank with the reagent barrel, described at least one
A second control valve is connected to atmosphere when liquid storage tank empties in the machine.
11. sample analyser as claimed in claim 10, which is characterized in that at least one described second control valve and it is described extremely
It connects one to one between liquid storage tank in a few machine, liquid storage at least one described second control valve and at least one described machine
It connects one to one between pond.
12. sample analyser as claimed in claim 8, which is characterized in that the agent delivery device further includes waste liquid pool, institute
State the test solution that waste liquid pool collects the reaction unit and the detection device, the waste liquid pool setting it is described at least one first
Between control valve and the power source, the power source empties the waste liquid of waste liquid pool to waste liquid pool offer positive pressure, described
Power source provides negative pressure to the waste liquid pool to collect waste liquid to the waste liquid pool；The waste liquid pool connects liquid storage in the machine
Pond provides negative pressure for liquid storage tank in the machine, so that the reagent of the reagent barrel enters liquid storage tank in the machine.
13. sample analyser as described in claim 1, which is characterized in that the capacity of liquid storage tank is no more than 100 millis in the machine
It rises.
14. sample analyser as claimed in claim 8, which is characterized in that liquid storage tank further includes liquid at least one described machine
Position inductor, the controller control corresponding with the level sensor when the level sensor senses the first liquid level
First control valve close and to stop the liquid storage tank into the machine corresponding with the level sensor charge reagent, it is described
Controller controls the agent delivery device and stops to the reaction unit when the level sensor senses the second liquid level
Reagent is provided.
15. sample analyser as claimed in claim 14, which is characterized in that the controller controls the agent delivery device
Stop after providing reagent to the reaction unit, the controller control corresponding with the level sensor described first controls
Valve is opened to execute the movement charged again, and the controller is in the first liquid level that the level sensor senses, control
First control valve corresponding with the level sensor is closed to stop charging.
16. sample analyser as claimed in claim 14, which is characterized in that the controller incudes in the level sensor
When to third liquid level, issue without reagent fault message, at the same the reagent in the machine in liquid storage tank be persistently transferred to it is described
The reaction unit that liquid storage tank connects in machine.
17. a kind of agent delivery method of sample analyser, comprising steps of
Liquid storage tank in one machine with reagent is provided, is tried outside liquid storage tank and the machine being connected with liquid storage tank in the machine in the machine
Confined space is formed between agent bucket；
A reagent transfer device is provided, reagent transfer device liquid storage tank out of described machine, which delivers reagents into the machine, to be stored up
While the reaction unit of liquid pool connection, negative pressure is formed in the confined space；And
The negative pressure promotes in the machine liquid storage tank to draw reagent from the reagent barrel to replenish in the machine in liquid storage tank.
18. agent delivery method as claimed in claim 17, which is characterized in that the reagent transfer device is transplanted on institute every time
It is equal with the amount for adding to the reagent of liquid storage tank in the machine every time to state the amount of the reagent of liquid storage tank in machine.
19. agent delivery method as claimed in claim 18, which is characterized in that the agent delivery method further comprises the steps of:
Obtain the liquid level information of the reagent of liquid storage tank in the machine；
When judging that the liquid level is in the second liquid level, the reagent transfer device stopping movement being controlled.
20. agent delivery method as claimed in claim 19, which is characterized in that the agent delivery method further comprises the steps of:
The reagent transfer device stopping movement, generates without reagent fault message；
After obtaining Failure elimination information, liquid storage tank is tried in reagent barrel by transfer outside a machine under the driving of power source in the machine
Liquid storage tank in agent to the machine；
The liquid level information for obtaining the reagent of liquid storage tank in the machine when judging that the liquid level is in the first liquid level, stops reagent and moves
It send.
21. agent delivery method as claimed in claim 18, which is characterized in that the agent delivery method further comprises the steps of:
The liquid level information for obtaining the reagent of liquid storage tank in the machine when judging that the liquid level is in third liquid level, is generated without reagent
Fault message, at the same the reagent transfer device still according to detection need out of described machine liquid storage tank transfer reagent to the machine
The reaction unit of interior liquid storage tank connection.
22. agent delivery method as claimed in claim 21, which is characterized in that the agent delivery method further comprises the steps of:
After obtaining Failure elimination information, liquid storage tank transfers reagent in reagent barrel outside a machine under the driving of power source in the machine
Liquid storage tank is charged in the machine, and during charging, and the reagent transfer device is still needed according to detection from described
The reaction unit that liquid storage tank transfer reagent is extremely connect with liquid storage tank in the machine in machine；
When the level sensor senses that the liquid level in the machine in liquid storage tank is in the first liquid level, stops reagent and be transplanted on
Liquid storage tank in the machine.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2017/120373 WO2019127562A1 (en) | 2017-12-30 | 2017-12-30 | Sample analyzer and reagent supply method therefor |
| CNPCT/CN2017/120373 | 2017-12-30 |
Publications (1)
| Publication Number | Publication Date |
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| CN109991431A true CN109991431A (en) | 2019-07-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201780097032.XA Pending CN111373262A (en) | 2017-12-30 | 2017-12-30 | Sample analyzer and reagent supply method thereof |
| CN201811521942.9A Pending CN109991431A (en) | 2017-12-30 | 2018-12-12 | Sample analyser and its agent delivery method |
| CN201822091238.6U Active CN210037838U (en) | 2017-12-30 | 2018-12-12 | Sample analyzer |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201780097032.XA Pending CN111373262A (en) | 2017-12-30 | 2017-12-30 | Sample analyzer and reagent supply method thereof |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201822091238.6U Active CN210037838U (en) | 2017-12-30 | 2018-12-12 | Sample analyzer |
Country Status (2)
| Country | Link |
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| CN (3) | CN111373262A (en) |
| WO (1) | WO2019127562A1 (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110687307A (en) * | 2019-09-24 | 2020-01-14 | 香港大德昌龙生物科技有限公司 | In-vitro diagnostic reagent supplementing method, system, equipment and storage medium |
| CN111373262A (en) * | 2017-12-30 | 2020-07-03 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyzer and reagent supply method thereof |
| CN112763738A (en) * | 2019-11-01 | 2021-05-07 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid supply system |
| CN112782418A (en) * | 2019-11-01 | 2021-05-11 | 深圳迈瑞生物医疗电子股份有限公司 | External liquid supply device and liquid supply method |
| CN112904030A (en) * | 2019-12-03 | 2021-06-04 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid supply system and method thereof |
| CN112904036A (en) * | 2019-12-03 | 2021-06-04 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid supply system and method thereof |
| CN113030478A (en) * | 2019-12-25 | 2021-06-25 | 深圳迈瑞生物医疗电子股份有限公司 | Specific protein reaction tank and specific protein detection system |
| CN114113004A (en) * | 2020-08-28 | 2022-03-01 | 深圳市帝迈生物技术有限公司 | Waste liquid treatment method and device and sample analyzer |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112180047A (en) * | 2020-11-18 | 2021-01-05 | 广东省特种设备检测研究院 | Hydrogen absorption agent dehydrogenation testing device and detection method |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1030516A (en) * | 1962-07-21 | 1966-05-25 | Ckd Dukla | Improvements in or relating to automatic dispensing of liquids |
| CN102116771A (en) * | 2010-01-04 | 2011-07-06 | 深圳市亚辉龙生物科技有限公司 | Enzyme-linked immune analysis method and fully-automatic enzyme-linked immune analyzer |
| CN102356318A (en) * | 2009-03-18 | 2012-02-15 | 希森美康株式会社 | Specimen analyzer |
| CN102565063A (en) * | 2010-12-31 | 2012-07-11 | 深圳迈瑞生物医疗电子股份有限公司 | Reagent detection device, system, method, blood analysis device |
| CN105004872A (en) * | 2015-07-19 | 2015-10-28 | 武汉明德生物科技股份有限公司 | Full-automatic immuno-quantitation analyzer |
| JP2016148530A (en) * | 2015-02-10 | 2016-08-18 | 株式会社島津製作所 | Amino acid sequence analysis device |
| CN208334379U (en) * | 2017-12-30 | 2019-01-04 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyser |
| CN111373262A (en) * | 2017-12-30 | 2020-07-03 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyzer and reagent supply method thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101201361B (en) * | 2006-12-15 | 2012-09-05 | 深圳迈瑞生物医疗电子股份有限公司 | Gas-liquid insulation device for storing liquid |
| CN101246180B (en) * | 2007-02-16 | 2012-11-21 | 深圳迈瑞生物医疗电子股份有限公司 | Blood cell analyzer cleaning agent automatic filling method and device |
| JP5550364B2 (en) * | 2010-01-26 | 2014-07-16 | シスメックス株式会社 | Reagent preparation device |
| MX2012012066A (en) * | 2010-04-16 | 2012-12-17 | Opko Diagnostics Llc | Feedback control in microfluidic systems. |
| JP5705579B2 (en) * | 2011-02-18 | 2015-04-22 | 株式会社日立ハイテクノロジーズ | Analysis equipment |
| WO2013052318A1 (en) * | 2011-09-25 | 2013-04-11 | Theranos, Inc. | Systems and methods for multi-analysis |
| JP6050939B2 (en) * | 2012-02-08 | 2016-12-21 | 株式会社日立ハイテクノロジーズ | Container and apparatus for holding the container |
| WO2014178085A2 (en) * | 2013-05-02 | 2014-11-06 | Ashish Jain | A system integrated with communicating device for medical analysis of biological matter |
-
2017
- 2017-12-30 WO PCT/CN2017/120373 patent/WO2019127562A1/en active Application Filing
- 2017-12-30 CN CN201780097032.XA patent/CN111373262A/en active Pending
-
2018
- 2018-12-12 CN CN201811521942.9A patent/CN109991431A/en active Pending
- 2018-12-12 CN CN201822091238.6U patent/CN210037838U/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1030516A (en) * | 1962-07-21 | 1966-05-25 | Ckd Dukla | Improvements in or relating to automatic dispensing of liquids |
| CN102356318A (en) * | 2009-03-18 | 2012-02-15 | 希森美康株式会社 | Specimen analyzer |
| CN102116771A (en) * | 2010-01-04 | 2011-07-06 | 深圳市亚辉龙生物科技有限公司 | Enzyme-linked immune analysis method and fully-automatic enzyme-linked immune analyzer |
| CN102565063A (en) * | 2010-12-31 | 2012-07-11 | 深圳迈瑞生物医疗电子股份有限公司 | Reagent detection device, system, method, blood analysis device |
| JP2016148530A (en) * | 2015-02-10 | 2016-08-18 | 株式会社島津製作所 | Amino acid sequence analysis device |
| CN105004872A (en) * | 2015-07-19 | 2015-10-28 | 武汉明德生物科技股份有限公司 | Full-automatic immuno-quantitation analyzer |
| CN208334379U (en) * | 2017-12-30 | 2019-01-04 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyser |
| CN111373262A (en) * | 2017-12-30 | 2020-07-03 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyzer and reagent supply method thereof |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111373262A (en) * | 2017-12-30 | 2020-07-03 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyzer and reagent supply method thereof |
| CN110687307A (en) * | 2019-09-24 | 2020-01-14 | 香港大德昌龙生物科技有限公司 | In-vitro diagnostic reagent supplementing method, system, equipment and storage medium |
| CN112763738A (en) * | 2019-11-01 | 2021-05-07 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid supply system |
| CN112782418A (en) * | 2019-11-01 | 2021-05-11 | 深圳迈瑞生物医疗电子股份有限公司 | External liquid supply device and liquid supply method |
| CN112782418B (en) * | 2019-11-01 | 2024-02-27 | 深圳迈瑞生物医疗电子股份有限公司 | External liquid supply device and liquid supply method |
| CN112763738B (en) * | 2019-11-01 | 2024-04-05 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid supply system |
| CN112904030A (en) * | 2019-12-03 | 2021-06-04 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid supply system and method thereof |
| CN112904036A (en) * | 2019-12-03 | 2021-06-04 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid supply system and method thereof |
| CN112904036B (en) * | 2019-12-03 | 2024-02-06 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid supply system and method thereof |
| CN113030478A (en) * | 2019-12-25 | 2021-06-25 | 深圳迈瑞生物医疗电子股份有限公司 | Specific protein reaction tank and specific protein detection system |
| CN114113004A (en) * | 2020-08-28 | 2022-03-01 | 深圳市帝迈生物技术有限公司 | Waste liquid treatment method and device and sample analyzer |
Also Published As
| Publication number | Publication date |
|---|---|
| CN210037838U (en) | 2020-02-07 |
| WO2019127562A1 (en) | 2019-07-04 |
| CN111373262A (en) | 2020-07-03 |
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