CN101246180B - Blood cell analyzer cleaning agent automatic filling method and device - Google Patents
Blood cell analyzer cleaning agent automatic filling method and device Download PDFInfo
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- CN101246180B CN101246180B CN2007100733820A CN200710073382A CN101246180B CN 101246180 B CN101246180 B CN 101246180B CN 2007100733820 A CN2007100733820 A CN 2007100733820A CN 200710073382 A CN200710073382 A CN 200710073382A CN 101246180 B CN101246180 B CN 101246180B
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Abstract
The invention discloses a blood cell analyzer automatic perfusion method, including absorbing cleaning liquid, emptying and cleaning three steps; wherein the cleaning step is back flush, that is the cleaning liquid goes from the counting pool back pool into the counting pool front pool through gem hole for cleaning. A kind of blood cell analyzer cleaning liquid automatic perfusion device, including counting pool, positive and negative pressure device, liquid storage device and liquid supplier; each of the liquid supplier and liquid storage device has one end connecting to the counting pool back pool; the cleaning liquid goes from the liquid supplier into the liquid storage device under the negative pressure which is produced by positive and negative pressure device; then the cleaning liquid goes from the counting pool back pool and gem hole, and back flushes into counting pool front pool for cleaning under positive pressure which is produce by positive and negative pressure device. The blood cell analyzer cleaning liquid automatic perfusion method provided by invention has high reliability, good cleaning effect, and the blood cell analyzer cleaning liquid automatic perfusion device liquid route has simple design and low cost.
Description
Technical field
The present invention relates to a kind of blood cell analyzer cleaning agent automatic filling method, and a kind of blood cell analyzer cleaning agent automatic filling device of realizing this method.
Background technology
Blood cell analyzer belongs to medical exact instrument, needs the perfusion cleaning solution to carry out every day/periodic maintenance.Blood cell analyzer has two kinds of cleaning solution reperfusion modes in the market: a kind of is that machine is outer by the perfusion of the manual auxiliary engine completion of operating personnel cleaning solution; Another kind is to realize the cleaning solution perfusion in the machine automatically.The former needs machine to draw cleaning solution outward, more this kind of employing of general three classification blood cell analyzers mode of operation; The then more employing automatic filling of five classification blood cell analyzers mode.Can realize the machine of cleaning agent automatic filling in the market, mostly because liquid line structure complicacy and cost is higher; Though minority manufacturer can utilize lower cost to realize the automatic filling of blood cell analyzer cleaning agent, has reduced reliability simultaneously, has potential faults.Present following three kinds of schemes of blood cell analyzer cleaning agent automatic filling for example:
Scheme 1: the constant voltage source of the gas is realized cleaning agent automatic filling.
Fig. 1 is the liquid road schematic diagram of scheme 1.The 9th two-way valve 58 is opened emptying counting chamber 1.The 9th two-way valve 58 cuts out, 51 energisings of first air valve, and cleaning liquid pool 54 is connected with the negative pressure end of constant pressure source, cleans this moment to be negative pressure in the liquid pool 54, and the tenth two-way valve 56 is opened, and cleaning solution is sucked into cleaning liquid pool 54 under suction function.Close the tenth two-way valve 56 then, cleaning solution stops perfusion.After this first air valve, 51 outages, the malleation end of connection constant voltage source of the gas, the pressure conversion in the cleaning liquid pool 54 are malleation.The 11 two-way valve 53 is opened, and is stored in the cleaning solution in the cleaning liquid pool 54, under the positive pressure of constant voltage source of the gas, begins to pour into counting chamber 1.After counting chamber 1 perfusion finished, the 11 two-way valve 53 cut out, and stopped the cleaning solution perfusion.First two-way valve 2 is opened then, because this moment, waste liquid pool 55 was communicated with the negative pressure end of constant pressure source through second air valve 52, under the effect of negative pressure pressure reduction, the cleaning solution in the counting chamber 1 begins to pour into volume gauge line 3 in atmospheric pressure and waste liquid pool 55.After perfusion finishes, close first two-way valve 2.Pressure in the energising of second air valve 52, this moment waste liquid pool 55 convert malleation into by negative pressure, and the 12 two-way valve 57 is opened, the waste liquid in the emptying waste liquid pool 55, and last the 12 two-way valve 57, second air valve 52 cut off the power supply in succession, accomplish a working cycle.
This scheme is owing to need to use the constant voltage source of the gas, and constant voltage source of the gas cost is higher, causes machine cost to increase; And (kind of valve is many: liquid valve, air valve for liquid road complex design; The number of using is many), reliability is lower, while constant voltage source of the gas need select for use pressure regulator valve to be used, these also can increase the cost of machine; The sebific duct assembling of liquid road is by manual completion (there are differences between every machine), and machinery compartment resistance difference is big, may cause sebific duct to collapse holder, poor reliability.
Scheme 2: syringe is realized cleaning agent automatic filling.
Fig. 2 is the liquid road schematic diagram of scheme 2.At first the 4th T-valve 19 energising, its common port communicates with normal-closed end, pump 61,12 energisings of the 3rd two-way valve after this, the liquid in the emptying counting chamber 1, pump 61, the 3rd T-valve 19, the 3rd two-way valve 12 cut off the power supply then.The 3rd syringe 59 moves downward draws quantitative cleaning solution, 60 energisings of the 9th T-valve, and the 3rd syringe 59 moves upward and in counting chamber 1, adds cleaning solution, the 9th T-valve 60 outages subsequently.Pump 61, the 4th threeway 19 are switched on once more; Pressure chamber 14 is set up vacuum; After vacuum in pressure transducer 13 detects pressure chamber 14 reaches setting value; First two-way valve 2 is opened, and under the effect of vacuum pressure reduction, the cleaning solution that is stored in the counting chamber 1 begins to pour into volume gauge line 3 in external atmosphere pressure and pressure chamber 14.After perfusion finishes, first two-way valve 2, the 4th T-valve 19, pump 61 outages.
Shown in Figure 2 cleaning solution can also be realized automatic filling with shared same the syringe of dilution, on the basis of Fig. 2, adds a solenoid valve again can realize in order to be equipped with the implementation of separate syringe, does not remake at this to be described in detail.If this scheme is equipped with independently syringe for cleaning solution, then cost is higher; If the shared cover syringe of cleaning solution and dilution then exists cleaning solution to pollute the risk of dilution.
Scheme 3: the pump forward and backward realizes cleaning agent automatic filling.
Fig. 3 is the liquid road schematic diagram of scheme 3.At first pump PM is rotated in the forward, and the waste liquid (Waste) in RBC (the red blood cell red blood cell) counting chamber breaks valve LV1, second electromagnetism through first electromagnetism and breaks valve LV2, the first retaining valve CV1, the 3rd electromagnetism and break outside the valve LV3 discharge machine.Subsequently; The 3rd electromagnetism breaks valve LV3 energising; An end that is connected with waste liquid is pressed down; An end that is connected with cleaning solution (Cleaner) is opened, pump PM counter-rotating, and cleaning solution process liquid filter FLS, the second retaining valve CV2, second electromagnetism break valve LV2, first electromagnetism breaks valve LV1 and gets into the RBC counting chamber.After perfusion was accomplished, pump PM, the 3rd electromagnetism broke valve LV3 outage.The method of cleaning solution perfusion WBC (white blood cellcount leucocyte) counting chamber is similar with the method for perfusion RBC counting chamber, and difference is the waste liquid emptying, first electromagnetism broke valve LV1 and is in "on" position when cleaning solution poured into.
This scheme cost is low, but reliability also reduces simultaneously: cleaning solution and waste liquid all will pass through shared power source (pump PM), if do not select liquid filter (FLS) for use, and can be contaminated during cleaning solution process pump (PM); If add liquid filter (FLS), then increased the maintenance cost of machine self; If in time do not change, cause liquid filter (FLS) to stop up, cleaning solution can't be realized automatic filling.
Summary of the invention
The purpose of this invention is to provide a kind of reliable operation, and the good blood cell analyzer cleaning agent automatic filling method of cleaning performance, and realize that the blood cell analyzer cleaning agent automatic filling installation cost of this method is low.
For reaching the foregoing invention purpose, the technical scheme that the present invention adopts is: a kind of blood cell analyzer cleaning agent automatic filling method comprises and inhales cleaning solution step, evacuation step and cleaning step; Inhale the cleaning solution step and make among the device for storing liquid that cleaning solution is inhaled into counting chamber links to each other, evacuation step makes the waste liquid emptying of counting chamber, and cleaning step cleans for recoil, and promptly cleaning solution cleans through entering counting chamber forebay, jewel hole from the after-bay of counting chamber.
In the optimized technical scheme, inhaling the cleaning solution step is that cleaning solution is drawn into the device for storing liquid from liquid feed device under the suction function that positive negative pressure device produces.
In the optimized technical scheme, cleaning step is, before has been stored in the cleaning solution in the device for storing liquid, under the malleation that positive negative pressure device produces drives, counting chamber and the pipeline that is attached thereto cleaned.
A kind of cleaning agent automatic filling device of blood cell analyzer comprises counting chamber, positive negative pressure device, device for storing liquid and liquid feed device; Counting chamber comprises counting chamber forebay, counting chamber after-bay and is positioned at jewel hole 20 between the two; The counting chamber forebay connects positive negative pressure device through the 3rd two-way valve; The controllable connection cleaning solution of one end of liquid feed device, the other end is through the second two-way valve connection count pond after-bay; One end of device for storing liquid connects positive negative pressure device, and the other end is through the first two-way valve connection count pond after-bay; Make cleaning solution under the suction function that positive negative pressure device produces, enter into device for storing liquid through liquid feed device; Under the positive pressure that positive negative pressure device produces, recoil then and clean into the counting chamber forebay through counting chamber after-bay and jewel hole.
In the optimized technical scheme, liquid feed device is second T-valve, and the common port of second T-valve connects second two-way valve, and normal-closed end connects cleaning solution.
In the optimized technical scheme, device for storing liquid comprises volumescope buret and liquid storage pipe; And the volume sum of volumescope buret and liquid storage pipe is not less than the volume of counting chamber forebay.
In the optimized technical scheme, positive negative pressure device comprises pressure transducer, pressure chamber, the 3rd T-valve, gas liquid two purpose pump and the 4th T-valve; Pressure transducer is housed in the pressure chamber; The Chang Kaiduan of the 3rd T-valve connects the pressure chamber, normally closed termination ambient atmosphere, and common port connects an end of gas liquid two purpose pump, and the other end of gas liquid two purpose pump connects the common port of the 4th T-valve; The Chang Kaiduan of the 4th T-valve connects the pressure chamber, and normal-closed end connects extraneous; The 4th T-valve gets electric back and starts the gas liquid two purpose pump and make generation negative pressure in the pressure chamber; The 4th T-valve energising starts the gas liquid two purpose pump and makes generation malleation in the pressure chamber.
Further in the optimized technical scheme, positive negative pressure device also comprises first air strainer, and first air strainer is arranged between the normal-closed end and ambient atmosphere of the 3rd T-valve, makes to be filtered by the air in the 3rd T-valve normal-closed end entering machine.
In the optimized technical scheme, positive negative pressure device comprises pressure transducer, pressure chamber, the 3rd T-valve, the 8th T-valve, second syringe and the 4th T-valve; Pressure transducer is housed in the pressure chamber; The Chang Kaiduan of the 3rd T-valve connects the pressure chamber, normally closed termination ambient atmosphere, and common port connects the Chang Kaiduan of the 8th T-valve; And the common port of the 8th T-valve connects second syringe, and normal-closed end connects the common port of the 4th T-valve; The Chang Kaiduan of the 4th T-valve connects the pressure chamber, and normal-closed end connects extraneous; Second syringe moves downward and makes and produce negative pressure in the pressure chamber; The energising of the 3rd T-valve, second syringe moves downward, when moving to assigned address, the second syringe stop motion, the energising of the 8th T-valve, the outage of the 3rd T-valve, second syringe moves upward and makes the pressure chamber produce malleation.
Further in the optimized technical scheme, positive negative pressure device also comprises first air strainer, and first air strainer is arranged between the normal-closed end and ambient atmosphere of the 3rd T-valve, makes to be filtered by the air in the 3rd T-valve normal-closed end entering machine.
A kind of blood cell analyzer cleaning agent automatic filling method provided by the invention; Adopt cleaning solution to realize the automatic filling of cleaning solution from the method for counting chamber after-bay entering counting chamber forebay first; Cleaning solution gets into position to be cleaned without waste drains pump; Do not need liquid filter, stopped the possibility that the cleaning agent automatic filling failure is broken down fully, reliability is high.A kind of blood cell analyzer cleaning agent automatic filling device that the present invention provides; Because the foundation of negative pressure and malleation is all accomplished by same positive negative pressure device in the machine; Realize the automatic filling of cleaning solution with simple liquid road, thereby liquid road simplicity of design, greatly reduced the cost of machine self.
Description of drawings
Fig. 1 is the liquid road schematic diagram that the constant voltage source of the gas is realized cleaning agent automatic filling.
Fig. 2 is the liquid road schematic diagram that syringe is realized cleaning agent automatic filling.
Fig. 3 is the liquid road schematic diagram that the pump rotating realizes cleaning agent automatic filling.
Fig. 4 is the liquid road schematic diagram of the cleaning agent automatic filling device of first embodiment of the invention.
Fig. 5 is the liquid road schematic diagram of the blood cell analyzer of second embodiment of the invention cleaning agent automatic filling device.
Fig. 6 is the process flow diagram of the cleaning agent automatic filling device of second embodiment of the invention.
Fig. 7 is the liquid road schematic diagram of the cleaning agent automatic filling device of third embodiment of the invention.
Fig. 8 is the liquid road schematic diagram of the cleaning agent automatic filling device of fourth embodiment of the invention.
Embodiment
Embodiment one
The cleaning agent automatic filling device of a kind of blood cell analyzer that the embodiment of the invention one provides, its liquid road schematic diagram is as shown in Figure 4, comprises WBC counting chamber, liquid feed device, device for storing liquid and positive negative pressure device.Wherein the WBC counting chamber connects positive negative pressure device through the 3rd two-way valve 12, also connects liquid feed device through second two-way valve 8.Controllable dilution 10 and the cleaning solution 11 of connecting respectively of the other end of liquid feed device.The WBC counting chamber also connects device for storing liquid through first two-way valve 2, and the other end of device for storing liquid connects positive negative pressure device.
Wherein the WBC counting chamber comprises WBC counting chamber forebay 1, jewel hole 20 and WBC counting chamber after-bay 5, and if no special instructions, the WBC counting chamber all refers to WBC counting chamber forebay 1 in this instructions.Jewel hole 20 is between WBC counting chamber forebay 1 and WBC counting chamber after-bay 5.
Liquid feed device is second T-valve 9 in the present embodiment, and its common port (C) connects WBC counting chamber after-bay through second two-way valve 8, and Chang Kaiduan (NO) connects dilution 10, and normal-closed end (NC) connects cleaning solution 11.Dilution 10 is used for cleaning region of interest such as volumescope buret 3 and WBC counting chamber after count measurement is accomplished; Cleaning solution 11 be used for the every day/during periodic maintenance, soak region of interest such as volumescope buret 3 and WBC counting chamber.Device for storing liquid comprises volumescope buret 3, first liquid storage pipe 6, first T-valve 7 and second liquid storage pipe 15 in the present embodiment.One end of one end connecting line 4 of volumescope buret 3, but also connect WBC counting chamber after-bay 5 through first two-way valve 2; And pipeline 4 other ends connect the normal-closed end (NC) of first T-valve 7, and the common port of first T-valve 7 (C) passes through second liquid storage pipe, 15 connection pressure chambers 14, and its Chang Kaiduan (NO) connects the other end of volume gauge lines 3 through first liquid storage pipe 6.An end of volumescope buret 3 also connects second air strainer 22 through the 4th two-way valve 21 in the present embodiment.
Positive negative pressure device comprises pressure transducer 13, pressure chamber 14, the 3rd T-valve 16, first air strainer 17, gas liquid two purpose pump 18 and the 4th T-valve 19 in the present embodiment.Pressure chamber 14 is connected to pressure transducer 13, and the pressure of pressure chamber 14 is monitored.Pressure chamber 14 also connects WBC counting chamber 1 through the 3rd two-way valve 12, is used for the waste liquid in the emptying WBC counting chamber 1.Pressure chamber 14 also links to each other with the Chang Kaiduan (NO) of the 3rd T-valve 16; The normal-closed end of the 3rd T-valve 16 (NC) links to each other with first air strainer 17, and its common port (C) connects gas liquid two purpose pump 18; The other end of gas liquid two purpose pump 18 connects the common port (C) of the 4th T-valve 19, and its Chang Kaiduan (NO) connects pressure chamber 14.
Its course of work is:
Inhale cleaning solution: the 4th three-way solenoid valve 19 gets electric, and its common port (C) is communicated with normal-closed end (NC), opens 18 pairs of pressure chambers 14 of gas liquid two purpose pump and sets up vacuum.When the vacuum values in pressure transducer 13 detects pressure chamber 14 reaches setting value, the 4th T-valve 19,18 outages of gas liquid two purpose pump, 9 energisings of second T-valve, this moment, the common port (C) of second T-valve 9 was communicated with normal-closed end (NC).Second two- way valve 8,2 energisings of first two-way valve are opened; Cleaning solution 11 is in external atmosphere pressure and pressure chamber 14 under the pressure difference effect between the vacuum; Be stored among volumescope buret 3, first liquid storage pipe 6, second liquid storage pipe 15, three's volume sum gets into the cleaning solution of WBC counting chamber 1 when recoiling after a while.
Emptying WBC counting chamber: second T-valve 9, second two- way valve 8,2 outages of second two-way valve; The 3rd two-way valve 12 is opened; Simultaneously the 4th T-valve 19, gas liquid two purpose pump 18 are switched on once more; Be used for emptying WBC counting chamber 1, the 3rd two-way valve 12, gas liquid two purpose pump 18 are closed subsequently, and the 4th T-valve 19 switches to the preparation that Chang Kaiduan (NO) carries out the perfusion cleaning solution from normal-closed end (NC).
Recoil is cleaned: 16 energisings of the 3rd three-way solenoid valve; Normal-closed end this moment (NC) is conducted with common port (C); The normal-closed end of the 3rd three-way solenoid valve 16 (NC) connects first air strainer 17; Be used for filtering the airborne impurity that gets into pressure chamber 14 from normal-closed end (NC), 18 energisings of gas liquid two purpose pump begin to set up malleation.After pressure transducer 13 detects pressure in the pressure chamber 14 and reaches setting value; First two-way valve 2 is opened, and is stored in the pressure difference effect that cleaning solution in volumescope buret 3, first liquid storage pipe 6, second liquid storage pipe 15 exists between malleation and the external atmosphere pressure and passes through counting chamber after-bay 5, jewel hole 20 entering WBC counting chambers 1 down pressure chamber 14 in.After the cleaning solution to the WBC counting chamber 1 of waiting to recoil reaches set amount, close first two-way valve 2, gas liquid two purpose pump 18, the 3rd three-way solenoid valve 16 switches to Chang Kaiduan (NO) from normal-closed end (NC) simultaneously.In cleaning solution recoiled process to the WBC counting chamber 1, pressure transducer 13 was in monitoring state always, and this function guarantees that the malleations in pressure chamber 14 are in pressure constant state.
Said process is innovative point of the present invention place.
Embodiment two
As shown in Figure 5, the cleaning agent automatic filling device of a kind of blood cell analyzer that present embodiment provides has three passages, promptly can be to WBC counting chamber 1, and diff (differential, classification) carries out cleaning agent automatic filling with RBC counting chamber 34 in pond 23.
Wherein the WBC counting channel comprises: WBC counting chamber 1; First two-way valve 2; The first volumescope buret 3; First pipeline 4; WBC counting chamber forebay 5; First liquid storage pipe 6; First T-valve 7; Second two-way valve 8; Second T-valve 9; Dilution 10; Cleaning solution 11; The 3rd two-way valve 12; Pressure transducer 13; Pressure chamber 14; Second liquid storage pipe 15; The 3rd T-valve 16; First air strainer 17; Gas liquid two purpose pump 18; The 4th T-valve 19; The jewel hole 20 of WBC counting chamber 1; The 4th two-way valve 21 and second air strainer 22.
Wherein jewel hole 20 is between WBC counting chamber 1 and WBC counting chamber after-bay 5; WBC counting chamber after-bay 5 connects the first volumescope buret 3 and first pipeline 4 through first two-way valve 2; And first pipeline, 4 other ends connect the normal-closed end (NC) of first T-valve 7; And the common port of first T-valve 7 (C) passes through second liquid storage pipe, 15 connection pressure chambers 14, and its Chang Kaiduan (NO) connects the other end of the first volumescope buret 3 through first liquid storage pipe 6; The first volumescope buret 3 also connects second air strainer 22 through the 4th two-way valve 21.WBC counting chamber after-bay 5 also connects the common port (C) of second T-valve 9 through second two-way valve 8; The normal-closed end of second T-valve 9 (NC) connects cleaning solution 11; Its Chang Kaiduan (NO) connects dilution 10, is used for cleaning the first volumescope buret 3 after count measurement is accomplished.Common port (C) is connected with normal-closed end (NC) during 9 energisings of second three-way solenoid valve, and common port when not switching on (C) links to each other with Chang Kaiduan (NO).Pressure chamber 14 is connected to pressure transducer 13, and the pressure of pressure chamber 14 is monitored.Pressure chamber 14 also connects WBC counting chamber 1 through the 3rd two-way valve 12.Pressure chamber 14 also links to each other with the Chang Kaiduan (NO) of the 3rd T-valve 16; The normal-closed end of the 3rd T-valve 16 (NC) links to each other with first air strainer 17, and its common port (C) connects gas liquid two purpose pump 18; The other end of gas liquid two purpose pump 18 connects the common port (C) of the 4th T-valve 19, and its Chang Kaiduan (NO) connects pressure chamber 14.
Diff pond passage:
Diff pond passage comprise pressure transducer 13, pressure chamber 14, gas liquid two purpose pump 18, the 4th T-valve 19, diff pond 23, the 5th two-way valve 24, horizontal motor 25, motor vertical 26, sampling needle 27, clean swab 28, the 5th T-valve 29, the 6th T-valve 30, the 3rd liquid storage pipe 31, first syringe 32, the 6th two-way valve 33.
The RBC counting channel:
The RBC counting channel comprises pressure transducer 13, pressure chamber 14, the 3rd T-valve 16, first air strainer 17, gas liquid two purpose pump 18, the 4th T-valve 19, RBC counting chamber 34, the 7th two-way valve 42, RBC jewel hole 35, the 8th two-way valve 36, the 7th T-valve 40, the second volumescope buret 37, second pipeline 38, the 3rd pipeline 39, the 4th pipeline 41.Wherein in the pressure chamber 14 pressure transducer 13 is housed, is used for the pressure of pressure chamber 14 is monitored.Pressure chamber 14 also links to each other with the Chang Kaiduan (NO) of the 3rd T-valve 16; The normal-closed end of the 3rd T-valve 16 (NC) links to each other with first air strainer 17, and its common port (C) connects gas liquid two purpose pump 18; The other end of gas liquid two purpose pump 18 connects the common port (C) of the 4th T-valve 19, and its Chang Kaiduan (NO) connects pressure chamber 14.The common port of the 7th T-valve 40 (C) links to each other with pressure chamber 14 through the 4th pipeline 41; And its Chang Kaiduan (NO) links to each other with an end of the second volumescope buret through second pipeline 38; Its normal-closed end (NC) connects the other end of the second volumescope buret 37 through the 3rd pipeline 39, and passes through the after-bay that the 8th two-way valve 36 connects RBC counting chambers 34.The RBC counting chamber is also through the 7th two-way valve 42 connection pressure chambers.
Cleaning solution complete machine perfusion flow process is divided into following plurality of processes substantially:
Wherein cleaning solution perfusion WBC counting chamber passage comprises following process:
Set up vacuum: the 4th three-way solenoid valve 19 gets electric, and its common port (C) is communicated with normal-closed end (NC), opens 18 pairs of pressure chambers 14 of gas liquid two purpose pump and sets up vacuum.
Inhale cleaning solution then: when the vacuum values in pressure transducer 13 detects pressure chamber 14 reaches setting value, the 4th T-valve 19,18 outages of gas liquid two purpose pump, 9 energisings of second T-valve, this moment, the common port (C) of second T-valve 9 was communicated with normal-closed end (NC).Second two- way valve 8,2 energisings of first two-way valve are opened; Cleaning solution 11 is in external atmosphere pressure and pressure chamber 14 under the pressure difference effect between the vacuum; Be stored among volumescope buret 3, first liquid storage pipe 6, second liquid storage pipe 15, three's volume sum gets into the cleaning solution of WBC counting chamber when recoiling after a while.
Emptying WBC counting chamber again: second T-valve 9, second two- way valve 8,2 outages of second two-way valve; The 3rd two-way valve 12 is opened; Simultaneously the 4th T-valve 19, gas liquid two purpose pump 18 are switched on once more; Be used for emptying WBC counting chamber, the 3rd two-way valve 12, gas liquid two purpose pump 18 are closed subsequently, and the 4th T-valve 19 switches to the preparation that Chang Kaiduan (NO) carries out the perfusion cleaning solution from normal-closed end (NC).
Recoil is at last cleaned: 16 energisings of the 3rd three-way solenoid valve; Normal-closed end this moment (NC) is conducted with common port (C); The normal-closed end of the 3rd three-way solenoid valve 16 (NC) connects first air strainer 17; Be used for filtering the airborne impurity that gets into pressure chamber 14 from normal-closed end (NC), 18 energisings of gas liquid two purpose pump begin to set up malleation.After pressure transducer 13 detects pressure in the pressure chamber 14 and reaches setting value; First two-way valve 2 is opened, and is stored in the pressure difference effect that cleaning solution in volumescope buret 3, first liquid storage pipe 6, second liquid storage pipe 15 exists between malleation and the external atmosphere pressure and passes through counting chamber after-bay 5,20 entering WBC counting chamber forebays 1, jewel hole down pressure chamber 14 in.After the cleaning solution to the WBC counting chamber forebay 1 of waiting to recoil reaches set amount, close first two-way valve 2, gas liquid two purpose pump 18, the 3rd three-way solenoid valve 16 switches to Chang Kaiduan (NO) from normal-closed end (NC) simultaneously.In cleaning solution recoiled process to the WBC counting chamber forebay 1, pressure transducer 13 was in monitoring state always, and this function guarantees that the malleations in pressure chamber 14 are in pressure constant state.
Cleaning solution perfusion diff pond:
At first the 4th T-valve 19, gas liquid two purpose pump 18 electric, be used for the pressure of emptying pressure chamber 14, open the 5th two-way valve 24 subsequently, after the liquid in the diff pond 23 was drained, the 4th T-valve 19, gas liquid two purpose pump 18, the 5th two-way valve 24 cut off the power supply simultaneously.Horizontal motor 25 drives sampling needle 27 and moves to 1 top, WBC counting chamber forebay, and motor vertical 26 drives sampling needle 27 declines and gets into WBC counting chamber 1 subsequently.In sampling needle 27 motions, first syringe 32 moves downward, and draws quantitative dilution 10 from the 6th T-valve 30 Chang Kaiduan (NO).The 6th T-valve 30 energisings subsequently, its common port this moment (C) is communicated with normal-closed end (NC), and first syringe 32 continues to move downward from WBC counting chamber 1 draws quantitative cleaning solution, and the cleaning solution of absorption is stored in the 3rd liquid storage pipe 31.
The 4th T-valve 19, the 5th T-valve 29, the 6th two-way valve 33; Open gas liquid two purpose pump 18 then; First syringe 32 moves upward, and motor vertical 25 drives sampling needle 27 and also moves upward dilution cleaning sampling needle 27 outer walls that utilize first syringe 32 to get simultaneously.After sampling needle 27 moves to WBC counting chamber 1 top, the 4th T-valve 19, the 5th T-valve 29, the 6th two-way valve 33 and 18 outages of gas-liquid dual-purpose pump.Sampling needle 27 gets into diff pond 23, the first syringes 32 and moves upward the cleaning solution adding diff pond 23 that is stored in the 4th liquid storage pipe 31, diff pond 23 is cleaned the 6th T-valve 30 outages then.
Cleaning solution perfusion RBC counting channel:
The 4th T-valve 19, the 7th two-way valve 42, gas liquid two purpose pump 18 electric, treat that liquid in the RBC counting chamber 34 arrange after, three's while dead electricity.The method and the above-mentioned diff pond 23 interior cleaning solution methods that add that add cleaning solution in the RBC counting chamber 34 are similar, no longer are described in detail.Vacuum is set up in gas liquid two purpose pump 18,19 energisings of the 4th T-valve, and the 8th two-way valve 36 is opened, and under the effect of pressure reduction, the cleaning solutions in the RBC counting chamber 34 get into the second volumescope buret 37, second pipeline 38, the 4th pipeline 41 through jewel hole 35.Normal-closed end (NC) and common port (C) conducting during the energising of the 7th T-valve 40, cleaning solution get into the 3rd pipeline 39 this are soaked.After cleaning solution perfusion is accomplished, the 4th T-valve 19, the 8th two-way valve 36, the 7th T-valve 40 and 18 outages of gas liquid two purpose pump.In the whole RBC counting channel cleaning solution filling process, the vacuum in the pressure chamber 14 is in by the state of pressure transducer 13 monitorings always, is in pressure constant state when guaranteeing the cleaning solution perfusion.
Cleaning solution pours into the WBC counting channel once more:
Initial WBC counting channel is poured into to such an extent that cleaning solution has been recoiled to WBC counting chamber 1, needs once more it to be poured into.19 energisings of the 4th T-valve, its common port this moment (C) and normal-closed end (NC) conducting, gas liquid two purpose pump 18 is opened and is used to set up vacuum.After pressure transducer detects vacuum values and reaches setting value; The 4th T-valve 19, gas liquid two purpose pump 18 dead electricity; Simultaneously second T-valve 9, second two-way valve 8, first two-way valve 2; Cleaning solution 11 is the automatic filling first volumescope buret 3, first liquid storage pipe 6, second liquid storage pipe 15 under differential pressure action, first T-valve, 7 energisings subsequently, and first pipeline 4 is poured.After 4 perfusions of first pipeline finish, second T-valve 9.Second two-way valve 8, first two-way valve 2,7 outages of first T-valve.
Recover to measure SBR:
Gas liquid two purpose pump 18,19 energisings of the 4th T-valve, the liquid in emptying storage and the pressure chamber 14 at first, the 4th T-valve 19 outages subsequently, 16 energisings of the 3rd T-valve begin build-up pressure.When the pressure that pressure transducer 13 detects pressure chamber 14 was atmospheric pressure, the 3rd T- valve 16,18 outages of gas liquid two purpose pump were measured and are prepared recovering state and finish.
The 3rd embodiment
Fig. 6 is the liquid road schematic diagram of blood cell analyzer cleaning agent automatic filling device the 3rd embodiment of the present invention.Compare with first embodiment, change first two-way valve 2, the 4th two-way valve 21 into T-valve, cancel first T-valve 7, can realize and the first embodiment identical functions.For five classification blood cell analyzers, this scheme can cause gate time long and should not use, but can be used for three classification blood cell analyzers.
The 4th embodiment
Fig. 7 is the liquid road schematic diagram of blood cell analyzer cleaning agent automatic filling device the 3rd embodiment of the present invention; Compare with first embodiment; Replaced gas liquid two purpose pump 18 with second syringe 44; Add the 8th T-valve 45 simultaneously, can realize and the first embodiment identical functions, but this scheme cost is a little more than the scheme of first embodiment.
Above content is to combine concrete preferred implementation to the further explain that the present invention did, and can not assert that practical implementation of the present invention is confined to these explanations.For the those of ordinary skill of technical field under the present invention, under the prerequisite that does not break away from the present invention's design, can also make some simple deduction or replace, all should be regarded as belonging to protection scope of the present invention.
Claims (10)
1. blood cell analyzer cleaning agent automatic filling method; It is characterized in that; Said blood cell analyzer comprises counting chamber, liquid feed device, device for storing liquid and positive negative pressure device; Said counting chamber comprises counting chamber forebay, counting chamber after-bay and is positioned at jewel hole between the two; One end of said liquid feed device links to each other with said counting chamber after-bay through second two-way valve, and an end of said device for storing liquid links to each other with said counting chamber after-bay through first two-way valve, and the other end of said device for storing liquid connects said positive negative pressure device; Said cleaning agent automatic filling method comprises: inhale cleaning solution step, evacuation step and cleaning step; Suction cleaning solution step makes among the device for storing liquid that cleaning solution is inhaled into counting chamber links to each other; Evacuation step makes the waste liquid emptying of counting chamber forebay; Said cleaning step cleans for recoil, and promptly cleaning solution cleans through jewel hole (20) entering counting chamber forebays (1) from the after-bay (5) of counting chamber.
2. blood cell analyzer cleaning agent automatic filling method according to claim 1 is characterized in that said suction cleaning solution step is, cleaning solution is drawn into the device for storing liquid from liquid feed device under the suction function that positive negative pressure device produces.
3. blood cell analyzer cleaning agent automatic filling method according to claim 1 and 2; It is characterized in that said cleaning step is; Before be stored in the cleaning solution in the device for storing liquid, under the malleation that positive negative pressure device produces drives, counting chamber and the pipeline that is attached thereto cleaned.
4. the cleaning agent automatic filling device of a blood cell analyzer comprises counting chamber, positive negative pressure device, device for storing liquid and liquid feed device; Said counting chamber comprises counting chamber forebay (1), counting chamber after-bay (5) and is positioned at jewel hole (20) between the two; Said counting chamber forebay (1) connects said positive negative pressure device through the 3rd two-way valve (12); The controllable connection cleaning solution of one end of said liquid feed device (11); One end of said device for storing liquid connects said positive negative pressure device; It is characterized in that the said liquid feed device other end connects said counting chamber after-bay (5) through second two-way valve (8); The other end of said device for storing liquid makes cleaning solution under the suction function that positive negative pressure device produces, enter into device for storing liquid through liquid feed device through first two-way valve (2) connection count pond after-bay (5); Under the positive pressure that positive negative pressure device produces, clean then through counting chamber after-bay (5) and jewel hole (20) the counting chamber forebay (1) of recoiling.
5. cleaning agent automatic filling device according to claim 4 is characterized in that said liquid feed device is second T-valve (9), and the common port of said second T-valve (9) connects said second two-way valve (8), and normal-closed end connects cleaning solution (11).
6. the cleaning agent automatic filling device of blood cell analyzer according to claim 4 is characterized in that said device for storing liquid comprises volumescope buret (3) and liquid storage pipe; And the volume sum of said volumescope buret (3) and liquid storage pipe is not less than the volume of said counting chamber forebay (1).
7. according to the cleaning agent automatic filling device of the described blood cell analyzer of one of claim 4 to 6, it is characterized in that said positive negative pressure device comprises pressure transducer (13), pressure chamber (14), the 3rd T-valve (16), gas liquid two purpose pump (18) and the 4th T-valve (19); Pressure transducer (13) is housed in the said pressure chamber (14); The Chang Kaiduan of said the 3rd T-valve (16) connects pressure chamber (14), normally closed termination ambient atmosphere, and common port connects an end of said gas liquid two purpose pump (18), and the other end of gas liquid two purpose pump (18) connects the common port of said the 4th T-valve (19); The Chang Kaiduan of said the 4th T-valve (19) connects pressure chamber (14), and normal-closed end connects extraneous; The 4th T-valve (19) energising starts gas liquid two purpose pump (18) and makes and produce negative pressure in the pressure chamber (14); The 3rd T-valve (16) energising starts gas liquid two purpose pump (18) and makes and produce malleation in the pressure chamber (14).
8. the cleaning agent automatic filling device of blood cell analyzer according to claim 7; It is characterized in that said positive negative pressure device also comprises first air strainer (17); Said first air strainer (17) is arranged between the normal-closed end and ambient atmosphere of said the 3rd T-valve (16), makes the air that is got in the machine by the 3rd T-valve (16) normal-closed end be filtered.
9. according to the cleaning agent automatic filling device of the described blood cell analyzer of one of claim 4 to 6, it is characterized in that said positive negative pressure device comprises pressure transducer (13), pressure chamber (14), the 3rd T-valve (16), the 8th T-valve (45), second syringe (44) and the 4th T-valve (19); Pressure transducer (13) is housed in the said pressure chamber (14); The Chang Kaiduan of said the 3rd T-valve (16) connects pressure chamber (14), normally closed termination ambient atmosphere, and common port connects the Chang Kaiduan of said the 8th T-valve (45); And the common port of said the 8th T-valve (45) connects said second syringe (44), and normal-closed end connects the common port of said the 4th T-valve (19); The Chang Kaiduan of said the 4th T-valve (19) connects pressure chamber (14), and normal-closed end connects extraneous; Said second syringe (44) moves downward and makes and produce negative pressure in the pressure chamber (14); The 3rd T-valve (16) energising, second syringe (44) moves downward, move to assigned address after; The second syringe stop motion, the 8th T-valve (45) energising, the 3rd T-valve (16) outage; Second syringe moves upward, and makes pressure chamber (14) produce malleation.
10. the cleaning agent automatic filling device of blood cell analyzer according to claim 9; It is characterized in that said positive negative pressure device also comprises first air strainer (17); Said first air strainer (17) is arranged between the normal-closed end and ambient atmosphere of said the 3rd T-valve (16), makes the air that is got in the machine by the 3rd T-valve (16) normal-closed end be filtered.
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| CN2007100733820A CN101246180B (en) | 2007-02-16 | 2007-02-16 | Blood cell analyzer cleaning agent automatic filling method and device |
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| CN2007100733820A CN101246180B (en) | 2007-02-16 | 2007-02-16 | Blood cell analyzer cleaning agent automatic filling method and device |
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| CN101246180A CN101246180A (en) | 2008-08-20 |
| CN101246180B true CN101246180B (en) | 2012-11-21 |
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Effective date of registration: 20180626 Address after: 518057 the 1-4 floor of MINDRAY building, science and technology south twelve Road, Nanshan District high tech Industrial Park, Shenzhen, Guangdong. Co-patentee after: SHENZHEN MINDRAY SCIENTIFIC Co.,Ltd. Patentee after: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS Co.,Ltd. Address before: 518057 MINDRAY science and technology south twelve road MINDRAY high tech Industrial Park, Shenzhen, Guangdong Patentee before: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS Co.,Ltd. |
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Application publication date: 20080820 Assignee: Shenzhen Mindray Animal Medical Technology Co.,Ltd. Assignor: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS Co.,Ltd. Contract record no.: X2022440020009 Denomination of invention: A kind of blood cell analyzer cleaning liquid automatic perfusion method and device Granted publication date: 20121121 License type: Common License Record date: 20220804 |