CN109212175B

CN109212175B - Sample analyzer

Info

Publication number: CN109212175B
Application number: CN201810688653.1A
Authority: CN
Inventors: 刘隐明; 吴万; 谢子贤
Original assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd; Shenzhen Mindray Scientific Co Ltd
Current assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd; Shenzhen Mindray Scientific Co Ltd
Priority date: 2017-06-30
Filing date: 2018-06-28
Publication date: 2021-12-21
Anticipated expiration: 2038-06-28
Also published as: CN109212175A; CN114295815A

Abstract

The invention discloses a sample analyzer, which comprises a shell, a first clapboard, a cross beam, a reaction assembly and a sampling assembly. The shell comprises a first side plate and a second side plate which are arranged oppositely, and a third side plate and a fourth side plate which are connected between the first side plate and the second side plate oppositely. The first partition board is connected between the first side board and the second side board, and a first space is formed between the first partition board and the fourth side board. The crossbeam is installed in first baffle, and the crossbeam includes relative first end and second end, and first end is located first space, and the second end passes first curb plate in order to stretch out first space. The reaction assembly is contained in the first space and is positioned below the cross beam. The sampling assembly includes a sampler mounted on the beam and movable between a first end and a second end. The sample analyzer is reasonable in structural layout.

Description

Sample analyzer

Technical Field

The invention relates to the technical field of medical instruments, in particular to a sample analyzer.

Background

With the increasing demand for diversification of analysis functions of the hematology analyzer, more and more parts are required to be arranged on the hematology analyzer, so that the internal space of the hematology analyzer is more and more tense, and the difficulty of structural layout of the hematology analyzer is increased. If the structural layout is not reasonable, the blood cell analyzer is easy to have low testing speed and poor safety and reliability.

Disclosure of Invention

The invention aims to provide a sample analyzer with reasonable structural layout.

In order to achieve the above purpose, the embodiment of the invention adopts the following technical scheme:

there is provided a sample analyzer comprising:

the shell comprises a first side plate and a second side plate which are arranged oppositely, and a third side plate and a fourth side plate which are connected between the first side plate and the second side plate oppositely;

a first partition connected between the first side plate and the second side plate, a first space being formed between the first partition and the fourth side plate;

a cross member mounted to the first partition, the cross member including opposing first and second ends, the first end being located within the first space and the second end passing through the first side plate to protrude out of the first space;

the reaction assembly is accommodated in the first space and is positioned below the cross beam; and

a sampling assembly comprising a sampler mounted on the beam and movable between the first end and the second end.

Wherein the sample analyzer further comprises a second spacer connected between the first side plate and the second side plate, the second spacer forming a second space with the third side plate.

Preferably, the first space is larger than the second space.

The sampling assembly further comprises a first liquid valve group, a hydraulic sensor and a first injector, wherein the first liquid valve group, the hydraulic sensor and the first injector are mounted on the second partition plate, the first liquid valve group is arranged in the second space, and the first injector and the hydraulic sensor are arranged in the second space and located below the first liquid valve group.

Wherein the sample analyzer further comprises a drive assembly for driving a flow path in the sample analyzer, the drive assembly being located within the first space.

The driving assembly comprises an air storage tank group and an air pump, the air storage tank group is arranged in the first space, and the air pump is connected with the air storage tank group and used for establishing positive pressure and negative pressure for the air storage tank group.

The sample analyzer further comprises a pressure detection plate, the distance between the gas storage tank group and the first side plate is larger than the distance between the gas storage tank group and the second side plate, the pressure detection plate is arranged between the gas storage tank group and the second side plate, and the pressure detection plate is used for detecting the pressure of the gas storage tank group.

The air pump is used for establishing a first positive pressure in the first air storage tank, and the air pump is used for establishing a first negative pressure in the second air storage tank.

Wherein, the gas holder group still includes third gas holder and fourth gas holder, third gas tank connection first gas holder, so that first malleation is in establish the second malleation in the third gas holder, fourth gas tank connection first gas holder or the third gas holder, so that first malleation or second malleation are in establish the third malleation in the fourth gas holder, the third malleation is different from the second malleation.

The sample analyzer further comprises a fifth air storage tank, the fifth air storage tank is arranged in the first space and located below the air pump, and the fifth air storage tank is connected with the second air storage tank, so that the first negative pressure can establish a second negative pressure in the fifth air storage tank.

The sample analyzer further comprises a pressure building pipeline, a first end of the pressure building pipeline is connected with the air pump outlet, a second end of the pressure building pipeline is connected with the air storage tank group, and when the pipeline extends from the first end to the second end, the pipeline firstly runs downwards and then runs upwards.

The air storage tank set is internally provided with a floater, and the floater is used for giving an alarm when liquid feeding occurs in the air storage tank set.

The sample analyzer further comprises a first air valve group, the first air valve group is used for controlling the pressure building action in the air storage tank group, and the first air valve group is located in the first space.

The sample analyzer further comprises a liquid storage tank group and a second liquid valve group, the liquid storage tank group is arranged in the first space and located below the gas storage tank group, the second liquid valve group is used for controlling filling and liquid adding of the liquid storage tank group, and the second liquid valve group is located between the first partition plate and the liquid storage tank group.

The liquid storage tank group comprises a first liquid storage tank, a second liquid storage tank, a third injector and a first quantitative pump group, the third injector is used for filling liquid for the first liquid storage tank, the third injector is located between the first partition plate and the first liquid storage tank, and the first quantitative pump group is connected between the second liquid storage tank and the reaction assembly.

The liquid storage tank group further comprises a second fixed displacement pump, and the second fixed displacement pump is connected between the first fixed displacement pump group and the second liquid storage tank and used for providing standby liquid for the reaction assembly.

The sample analyzer further comprises a split plate, the split plate is rotatably connected with the second side plate and located between the first partition plate and the fourth side plate, and the split plate is used for installing the liquid storage pool group.

Wherein the sample analyzer further comprises a reagent pool for storing reagents involved in processing of the biological sample, the reagent pool being mounted to the second partition and located in the second space.

The reagent pool group comprises a plurality of reagent pools, a first switch valve, a second switch valve, a first pipeline and a second pipeline, wherein the first switch valve is used for connecting a positive pressure source, the first pipeline is connected between the reagent pools and the first switch valve, the second switch valve is used for connecting a negative pressure source, and the second pipeline is connected between the reagent pools and the second switch valve.

The reagent pool group further comprises a plurality of first branches and a plurality of second branches, the first branches are connected between the reagent pools and the first pipelines in a one-to-one correspondence mode, each first branch is provided with a one-way valve, the second branches are connected between the reagent pools and the second pipelines in a one-to-one correspondence mode, and each second branch is provided with a one-way valve.

The sample analyzer further comprises a third liquid valve group and a second quantitative pump group, the third liquid valve group and the second quantitative pump group are connected between the reagent tank group and the reaction assembly, and the third liquid valve group is arranged in the second space and located below the reagent tank group.

The sample analyzer further comprises a plurality of third pipelines connected between the third liquid valve group and the reaction assembly, and the third pipelines comprise a first part, a connecting part and a second part which are sequentially connected, the first part is connected with the third liquid valve group, the second part is connected with the reaction assembly, the reaction assembly is located below the third liquid valve group, a first height difference is formed between two ends of the first part, a second height difference is formed between two ends of the second part, and the connecting part is used for preventing bubbles from entering the second part into the first part.

Wherein the volume of the first portion is less than the volume of the dosing pumps in the second dosing pump group.

The sample analyzer further comprises a second air valve group, the second air valve group is connected with the liquid storage tank group and the reagent tank group, and the second air valve group is arranged in the second space and is positioned between the reagent tank group and the first side plate.

The sample analyzer further comprises a reagent joint and a fourth liquid valve group, the reagent joint is fixed on the second side plate and used for inputting a reagent into the reagent pool group, and the fourth liquid valve group is connected between the reagent joint and the reagent pool group.

The sample analyzer further comprises an optical coupling detection assembly, the optical coupling detection assembly is connected between the reagent joint and the fourth liquid valve group, and the optical coupling detection assembly is located below the fourth liquid valve group.

The reaction assembly comprises a first reaction tank, a second reaction tank, a third reaction tank and a fourth reaction tank, wherein the first reaction tank is used for forming a first liquid to be detected for detecting hemoglobin count, the second reaction tank is used for forming a second liquid to be detected for detecting white blood cell count, the third reaction tank is used for forming a third liquid to be detected for detecting white blood cell classification, and the fourth reaction tank is used for forming a fourth liquid to be detected for detecting red blood cell count.

The first reaction tank, the second reaction tank, the third reaction tank and the fourth reaction tank are sequentially arranged in the direction from the second end to the first end of the cross beam.

The reaction assembly further comprises a fifth reaction tank, the fifth reaction tank is used for forming a fifth solution to be detected for detecting reticulocyte count, and the fifth reaction tank is arranged between the third reaction tank and the fourth reaction tank.

Wherein the second test solution is also used for detecting the classification of nucleated red blood cells and the classification of basophils.

The sample analyzer further comprises a first liquid valve and a third quantitative pump, the first liquid valve is connected between the first reaction tank and the third quantitative pump, and the first liquid valve and the third quantitative pump are both arranged in the first space and located below the liquid level of the first reaction tank.

Wherein the sample analyzer further comprises a flow chamber and a second syringe, the flow chamber is arranged in the first space and above the cross beam, and the second syringe is arranged in the housing and below the flow chamber.

Wherein the sample analyzer further comprises a third partition disposed in the first space and connected between the first partition and the third side plate, and the flow chamber is disposed above the third partition; the sample analyzer further comprises an air pump arranged in the first space, and the air pump is arranged below the third partition plate.

The reaction assembly comprises a second reaction tank, a third reaction tank and a fifth reaction tank, wherein the second reaction tank is used for forming a second solution to be detected for detecting the white blood cell count, the third reaction tank is used for forming a third solution to be detected for detecting the white blood cell classification, and the fifth reaction tank is used for forming a fifth solution to be detected for detecting the reticulocyte count;

the sample analyzer further comprises a fourth pipeline, the flow chamber is connected with a first access point of the fourth pipeline, the second reaction tank is connected with a second access point of the fourth pipeline, the third reaction tank is connected with a third access point of the fourth pipeline, the fifth reaction tank is connected with a fourth access point of the fourth pipeline, and the first access point, the second access point, the third access point and the fourth access point are sequentially arranged on the fourth pipeline.

The sample analyzer further comprises a pressure-breaking valve group and a third air valve group for controlling the pressure-breaking valve group, the pressure-breaking valve group is connected between the flow chamber and the reaction assembly, and the third air valve group is arranged in the first space and is positioned below the reaction assembly.

The sample analyzer further comprises a waste liquid treatment assembly, the waste liquid treatment assembly is mounted on the second partition plate and located in the second space, the waste liquid treatment assembly comprises a first waste liquid pool, a second waste liquid pool, a liquid pump and a fifth liquid valve group, the first waste liquid pool and the liquid pump are arranged at intervals and located below the fifth liquid valve group, and the second waste liquid pool is located between the fifth liquid valve group and the second side plate.

Wherein, the liquid waste treatment subassembly still includes connecting line, second liquid valve, level sensor and time delay controller, the connecting line is connected the second waste liquid pond with between the first waste liquid pond, the second liquid valve sets up on the connecting line, level sensor locates the second waste liquid pond, level sensor is used for detecting the liquid level height of waste liquid in the second waste liquid pond, time delay controller coupling level sensor with the second liquid valve, time delay controller is used for when the liquid level height reduces to the default, and the time delay is predetermine and is cut off the second liquid valve, so that be liquid, be gaseous in the partial pipeline of connecting line. Or, the liquid water disposal subassembly still includes connecting tube, second liquid valve and opto-coupler detection sensor, the connecting tube is connected the second waste liquid pond with between the first waste liquid pond, the second liquid valve sets up on the connecting tube, opto-coupler detection sensor locates connecting tube, when opto-coupler detection sensor detects that connecting tube appears gaseous, the second liquid valve stop work so that be liquid in the partial pipeline of connecting tube, be gaseous in the partial pipeline. The cover plate is located on one side, far away from the second side plate, of the first side plate, the cover plate is buckled with the first side plate to form a third space, and the dye assembly is located in the third space.

The dye assembly comprises a dye bag set, a third quantitative pump set and a sixth liquid valve set, and the third quantitative pump set and the sixth liquid valve set are located above the dye bag set.

Wherein, the sample analyzer further comprises a cover plate and a preheating assembly, the cover plate is positioned on one side of the first side plate far away from the second side plate, the cover plate is buckled with the first side plate to form a third space, and the preheating assembly is arranged on the first side plate and positioned in the third space.

A fourth space is formed between the first partition plate and the second partition plate, and the fourth space is used for arranging circuit traces of the sample analyzer.

Preferably, the sample analyzer further includes a fourth partition, the periphery of the fourth partition is connected to the first side plate, the second side plate, the third side plate and the fourth side plate and is located above the fourth space, and the fourth partition is used for carrying a circuit board and components;

the fourth partition board comprises a fixed part and a movable part which is rotatably connected with the fixed part, and the movable part is used for covering or opening part of the fourth space.

Compared with the prior art, the invention has the following beneficial effects:

in the sample analyzer according to the embodiment of the present invention, the sampler can move between the first end and the second end of the cross beam, and the reaction assembly is located below the cross beam, so that the sampler can collect a biological sample outside the housing, and then quickly move to a position above the reaction assembly along the direction from the second end to the first end to distribute the biological sample to the reaction assembly, and the sampling and distributing speed of the sampler is high. In short, the sample analyzer improves the testing speed of the sample analyzer by reasonably arranging the positions of the cross beam, the sampler and the reaction assembly, and the structural layout of the sample analyzer is reasonable.

Drawings

In order to more clearly illustrate the technical solution of the present invention, the drawings needed to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.

Fig. 1 is a schematic structural diagram of a sample analyzer according to an embodiment of the present invention.

FIG. 2 is a schematic block diagram of some of the components of the sample analyzer shown in FIG. 1.

Fig. 3 is a partially exploded view of the sample analyzer shown in fig. 1.

Fig. 4 is a schematic view of a portion of the sample analyzer shown in fig. 1.

Fig. 5 is another schematic structural view of a portion of the sample analyzer shown in fig. 1.

Fig. 6 is a schematic view from another perspective of the structure shown in fig. 5.

Fig. 7 is a schematic view of a further part of the structure of the sample analyzer shown in fig. 1.

Fig. 8 is a schematic view of still another part of the structure of the sample analyzer shown in fig. 1.

Fig. 9 is a schematic view of still another part of the structure of the sample analyzer shown in fig. 1.

FIG. 10 is a first schematic view showing a connection relationship of a part of the structure of the sample analyzer shown in FIG. 1.

Fig. 11 is a schematic view showing a connection relationship of a part of the structure of the sample analyzer shown in fig. 1.

Fig. 12 is a third schematic view showing a connection relationship of a part of the structure of the sample analyzer shown in fig. 1.

FIG. 13A is a schematic diagram of one connection of a third valve block and a reaction block of the sample analyzer of FIG. 1.

FIG. 13B is a schematic view of another connection of a third valve block to a reaction block of the sample analyzer of FIG. 1.

FIG. 13C is a schematic diagram of yet another connection of a third valve block and a reaction block of the sample analyzer of FIG. 1.

FIG. 13D is a schematic diagram of yet another connection of a third valve block to a reaction block of the sample analyzer of FIG. 1.

FIG. 13E is a schematic view of yet another connection of a third valve block to a reaction block of the sample analyzer of FIG. 1.

Fig. 14 is a schematic view showing a connection relationship of a part of the structure of the sample analyzer shown in fig. 1.

Fig. 15 is a schematic view showing a connection relationship of a part of the structure of the sample analyzer shown in fig. 1.

Fig. 16 is a schematic view six of the connection of the partial structure of the sample analyzer shown in fig. 1.

Detailed Description

Embodiments of the present application are described below with reference to the accompanying drawings.

Referring to fig. 1 to 8, a sample analyzer 100 is provided according to an embodiment of the present invention. The sample analyzer 100 may be used to perform analysis of a biological sample, which may be blood or the like. The sample analyzer 100 further includes a driving assembly 1, a sampling assembly 2, a reaction assembly 3, a detection assembly 4, a waste liquid disposal assembly 5, and a controller 6. The drive assembly 1 is used to drive various flow paths (including gas and liquid paths) in the sample analyzer 100. The sampling assembly 2 is used to collect and dispense biological samples. The reaction component 3 is used for processing the biological sample to form a liquid to be detected. The detection component 4 is used for detecting the liquid to be detected to form detection information. The waste liquid disposal assembly 5 is used to collect and discharge waste liquid in the sample analyzer 100. The controller 6 is used to control the workflow of the sample analyzer 100 and process the detection information to form an analysis result.

The sample analyzer 100 further includes a housing 71, a first partition 721, and a cross-member 73. The housing 71 includes a first side plate 711 and a second side plate 712 disposed opposite to each other, and a third side plate 713 and a fourth side plate 714 connected between the first side plate 711 and the second side plate 712 opposite to each other. The first partition 721 is connected between the first side plate 711 and the second side plate 712. A first space 741 is formed between the first partition 721 and the fourth side plate 714. The cross member 73 is mounted to the first partition 721. The cross member 73 includes a first end 731 and a second end 732 opposite to each other, the first end 731 is located in the first space 741, and the second end 732 passes through the first side plate 711 to protrude out of the first space 741. The cross beam 73 extends from the first end 731 to the second end 732, i.e., from the interior of the housing 71 to the exterior of the housing 71. The reaction unit 3 is accommodated in the first space 741 and located below the cross beam 73. The sampling assembly 2 includes a sampler 21 (e.g., a sampling needle), the sampler 21 being mounted on the cross-beam 73 and movable between the first end 731 and the second end 732.

In this embodiment, since the sampler 21 can move between the first end 731 and the second end 732 of the cross beam 73 and the reaction assembly 3 is located below the cross beam 73, the sampler 21 can collect a biological sample outside the housing, and then move quickly along the second end 732 toward the first end 731 to above the reaction assembly 3 to distribute the biological sample to the reaction assembly 3, so that the sampling and distributing speed of the sampler 21 is fast. In short, the sample analyzer 100 increases the testing speed of the sample analyzer 100 by properly arranging the cross beam 73, the sampler 21 and the reaction assembly 3, and the structural layout of the sample analyzer 100 is reasonable.

Optionally, the housing 71 further includes a top plate 715 and a bottom plate 716, which are oppositely disposed, the first side plate 711, the second side plate 712, the third side plate 713, and the fourth side plate 714 are disposed end-to-end between the top plate 715 and the bottom plate 716, and the housing 71 encloses a relatively closed space for arranging most of the structure of the sample analyzer 100. Any two plates of the housing 71 disposed opposite each other may be disposed substantially in parallel, and any two plates of the housing 71 connected to each other may be disposed substantially vertically. The first partition 721 is disposed opposite to the fourth side plate 714.

Optionally, the sample analyzer 100 further comprises a second spacer 722. The second partition 722 is connected between the first side plate 711 and the second side plate 712, and a second space 742 is formed between the second partition 722 and the third side plate 713. In this case, the first space 741 is spaced apart from the second space 742.

The first space 741 is larger than the second space 742. The components of the sample analyzer 100 can be flexibly disposed in the first space 741 and the second space 742 according to their volume and their connection relationship with each other. For example, a bulky device may be optionally arranged in the first space 741.

Referring to fig. 1 to 9, as an alternative embodiment, the sampling assembly 2 further includes a first valve set 81 mounted on the second partition 722, a hydraulic sensor 22, and a first injector 23. The first valve block 81 is disposed in the second space 742, and the first injector 23 and the hydraulic sensor 22 are disposed in the second space 742 and below the first valve block 81. The first injector 23 is disposed below the first valve set 81, which is beneficial to avoiding generating bubbles and easily discharging bubbles. The hydraulic sensor 22 may be located above the first injector 23 and below the first valve block 81. The first fluid valve set 81 includes at least two fluid valves. The first valve group 81 is used for coordinating the sampling and sample separating actions of the sampling assembly 2.

Optionally, the sampling assembly 2 further includes a first fixed displacement pump 91, and the first fixed displacement pump 91 is disposed in the second space 742 and below the first fluid valve group 81. The first quantitative pump 91 is arranged below the first liquid valve group 81, so that bubbles are prevented from being generated and are easily discharged. The first constant volume pump 91 is connected to the sampler 21, and the first constant volume pump 91 is connected to a diluent reagent tank, and can store a constant volume of diluent. After the sampler 21 sucks the once diluted biological sample, the diluent in the first constant volume pump 91 can perform secondary dilution on the biological sample in the sampler 21. The diluent in the first dosing pump 91 can also be used to flush the tubing of the sampling assembly 2. It will be appreciated by those skilled in the art that the first dosing pump 91 may not be required if a second dilution of the biological sample is not required.

Referring to fig. 1 to 11, as an alternative embodiment, the driving element 1 is located in the first space 741. The driving assembly 1 with a large overall volume is disposed in the first space 741 with a large volume, which is beneficial to improving the space utilization rate of the first space 741, so that the internal structure arrangement of the sample analyzer is more reasonable.

The driving assembly 1 of the sample analyzer 100 includes an air tank group 11 and an air pump 12 disposed in the first space 741. The air pump 12 is connected with the air tank group 11 and used for establishing positive pressure and negative pressure for the air tank group 11. The air pump 12 is arranged below the air storage tank group 11. The gas tank set 11 and the air pump 12 are part of the driving assembly 1.

During the use, the air pump 12 is in establish malleation and negative pressure in the gas storage tank group 11, malleation with the negative pressure is used for: driving the sampling assembly 2 to collect a biological sample; and/or driving the reaction component 3 to process the biological sample to form a liquid to be detected; and/or driving the detection component 4 to detect the liquid to be detected so as to form detection information.

In the present embodiment, the sample analyzer 100 uses the small-volume air pump 12 and the air tank set 11 as the main power source, so as to reduce the cost of the sample analyzer 100. The sample analyzer 100 has a highly concentrated layout of gas and liquid paths, and simultaneously performs gas-liquid separation as much as possible, and avoids the generation of bubbles in components with strict requirements on bubbles as much as possible. Since the gas tank 11 has a large volume, the gas tank 11 is disposed in the first space 741 to make more reasonable use of the internal space of the sample analyzer 100.

Optionally, the gas storage tank 11 is disposed above the first space 741, that is, the gas storage tank 11 is disposed above, so as to be isolated from the liquid circuit and the circuit in the sample analyzer 100 as much as possible, and thus the sample analyzer 100 has high safety and reliability.

Optionally, the sample analyzer 100 further comprises a pressure detection plate 13. The distance between the gas tank group 11 and the first side plate 711 is greater than the distance between the gas tank group 11 and the second side plate 712, the pressure detection plate 13 is disposed between the gas tank group 11 and the second side plate 712, and the pressure detection plate 13 is used for detecting the pressure of the gas tank group 11. And a pressure sensor is arranged on the pressure detection plate 13. At this time, the distance between the pressure detection plate 13 and the gas tank group 11 is small, and the connection pipe between the two is short, so that the pressure detection plate 13 can reflect the pressure change of the gas tank in real time.

Optionally, the air tank set 11 includes a first air tank 111 and a second air tank 112, the air pump 12 establishes a first positive pressure in the first air tank 111, and the air pump 12 establishes a first negative pressure in the second air tank 112. The first positive pressure and the first negative pressure may be used to drive various flow paths (including gas and liquid paths) in the sample analyzer 100. Optionally, the air pump 12 is disposed as close to the first air tank 111 and the second air tank 112 as possible, so as to shorten a pipeline between the air pump 12 and the first air tank 111 and the second air tank 112, thereby reducing a flow resistance. The first positive pressure may be 120KPa and the first negative pressure may be-40 KPa.

Optionally, the gas tank group 11 further includes a third gas tank 113 and a fourth gas tank 114. The third reservoir 113 is connected to the first reservoir 111 such that the first positive pressure creates a second positive pressure within the third reservoir 113. The fourth air tank 114 is connected to the first air tank 111 such that the first positive pressure creates a third positive pressure within the fourth air tank 114, the third positive pressure being different from the second positive pressure. The second positive pressure and the third positive pressure are both less than the first positive pressure. The second positive pressure and the third positive pressure may be used to drive different flow paths. The pressure building process of the second positive pressure and the third positive pressure can be carried out simultaneously or separately. The second positive pressure may be 90KPa and the third positive pressure may be 50 KPa. It will be appreciated by those skilled in the art that the fourth air tank 114 may be connected to the third air tank 113 such that the second positive pressure creates a third positive pressure within the fourth air tank 114.

Optionally, the sample analyzer 100 further comprises a fifth gas reservoir 115. The fifth air tank 115 is disposed in the first space 741 and below the air pump 12, and the fifth air tank 115 is connected to the second air tank 112, so that the first negative pressure creates a second negative pressure in the fifth air tank 115. The second negative pressure may be-30 kPa. Since the fifth air tank 115 urgently needs to use the second negative pressure as a power source (for example, for red blood cell detection), and meanwhile needs to collect waste liquid (for example, waste liquid generated by red blood cell detection), the fifth air tank 115 is disposed below the air pump 12, and at this time, the fifth air tank 115 is also disposed below the air tank group 11, so as to achieve gas-liquid isolation.

Optionally, the sample analyzer 100 further comprises a pressure build-up line 116. The first end 1161 of the pressure building pipeline 116 is connected to the outlet of the air pump 12, the second end 1162 of the pressure building pipeline 116 is connected to the air tank group 11, and when the pipeline extends from the first end 1161 to the second end 1162, the pipeline firstly runs downwards and then runs upwards. Since condensed water may exist in the compressed air of the air pump 12, when the pipeline extends from the first end 1161 to the second end 1162, the pipeline is extended from the lower end to the upper end, so that the condensed water can be prevented from flowing back to the air pump 12 when the air pump 12 does not work, and further the air pump 12 is prevented from being out of work. Neither the first reservoir 111 nor the second reservoir 112 is filled with liquid.

Optionally, a float 117 is arranged in the gas storage tank group 11, and the float 117 is used for giving an alarm when liquid feeding occurs in the gas storage tank group 11. For example, the first, second and

third air containers

111, 112 and 113 are all provided with the float 117 therein, and if liquid enters the first, second and

third air containers

111, 112 and 113, the float 117 floats and gives an alarm, thereby preventing the liquid from entering the air pump 12. In other embodiments, the float 117 may be disposed in the fourth air tank 114.

Optionally, the sample analyzer 100 further includes a first air valve set 101, the first air valve set 101 is used for controlling the pressure build-up action in the air tank set 11, and the first air valve set 101 is located in the first space 741. The first valve group 101 can be arranged below the gas storage tank group 11 and is close to the gas storage tank group 11 as much as possible, so that the length of the connecting pipe is shortened, and the flow resistance and the flow loss are reduced. The first valve set 101 includes at least two valves.

Referring also to fig. 1-10, as an alternative embodiment, the sample analyzer 100 further includes a reservoir set 20 and a second valve set 82. The liquid storage tank set 20 is disposed in the first space 741 and located below the gas storage tank set 11. The second valve set 82 is used for controlling the filling and filling of the liquid storage pool group 20, and the second valve set 82 is located between the first partition 721 and the liquid storage pool group 20. Second valve set 82 may be mounted to first partition 721. Second set of valves 82 includes at least two fluid valves.

Optionally, the reservoir set 20 includes a first reservoir 201 and a second reservoir 202, and the sample analyzer 100 further includes a third syringe 203 and a first quantitative pump set 92. The first reservoir 201 stores sheath fluid for optical sheath fluid measurement, which may be diluent. The second reservoir 202 stores a diluent for performing other measurements or washing. The third syringe 203 is used to fill the first reservoir 201 with liquid. The third syringe 203 is located between the first partition 721 and the first reservoir 201. The third syringe 203 may fill the first reservoir 201 with a replenishing liquid during the process of feeding the first reservoir 201 to other components. The first reservoir 201 is connected to the third air tank 113. The third air tank 113 is connected to the first reservoir 201 for driving the sheath fluid in the first reservoir 201 to flow out (to the flow chamber 41) by the second positive pressure. The first dosing pump unit 92 is connected between the second reservoir 202 and the reaction block 3. The first dosing pump unit 92 may be adapted to supply a metered amount of the dilution liquid in the second reservoir 202 to the reaction block 3. The first dosing pump group 92 comprises at least two dosing pumps.

Optionally, the reservoir set 20 further includes a second fixed displacement pump 93. The second fixed displacement pump 93 is connected between the first fixed displacement pump set 92 and the second liquid storage tank 202, and is used for providing standby liquid for the reaction assembly 3. When the diluent in the second reservoir 202 is sufficient, the second reservoir 202 provides liquid for the reaction module 3; when the diluent in the second reservoir 202 is insufficient, the second quantitative pump 93 provides a spare liquid for the reaction module 3. The second fixed displacement pump 93 is located in the first space 741. The second fixed displacement pump 93 is located between the two fixed displacement pumps of the first fixed displacement pump group 92.

Optionally, the sample analyzer 100 further comprises a shutter plate 75. The opening plate 75 is rotatably connected to the second side plate 712 and located between the first partition 721 and the fourth side plate 714, and the opening plate 75 is used for mounting the liquid storage battery pack 20. The fifth air container 115 may be provided on the opening plate 75. The rotatable arrangement of the opening plate 75 allows for more flexibility in the arrangement of components within the sample analyzer 100.

Referring to fig. 1-13D, as an alternative embodiment, the sample analyzer 100 further includes a reagent pool 30, wherein the reagent pool 30 is used for storing reagents involved in processing (e.g., diluting, reacting) the biological sample. The reagent reservoir 30 is installed on the second partition 722 and located in the second space 742. To facilitate the flow of reagents from the reagent reservoir 30 into the reaction block 3, the reagent reservoir 30 may be disposed above the reaction block 3.

Optionally, the reagent reservoir pack 30 comprises a plurality of reagent reservoirs 301. The sample analyzer 100 further includes a first switching valve 302, a second switching valve 303, a first conduit 304, and a second conduit 305. The first on-off valve 302 is used to connect a positive pressure source (e.g., the fourth air tank 114 that creates the third positive pressure). The first pipe 304 is connected between the plurality of reagent reservoirs 301 and the first on-off valve 302. The second on-off valve 303 is used to connect a negative pressure source (e.g., the fifth air tank 115 that generates the second negative pressure). The second pipe 305 is connected between the plurality of reagent reservoirs 301 and the second on-off valve 303. When the reagent barrel is used, the second switch valve 303 is switched on, so that the plurality of reagent pools 301 are communicated to a negative pressure source, and reagents in the reagent barrel outside the reagent barrel enter the plurality of reagent pools 301 under the action of a difference; then the second switch valve 303 is closed, the first switch valve 302 is opened, so that the plurality of reagent pools 301 are communicated to the positive pressure source, and the reagents in the plurality of reagent pools 301 flow into the reaction assembly 3 under the action of the pressure difference to participate in the biological sample processing process.

In this embodiment, since the plurality of reservoir groups 20 share the first switching valve 302 and the second switching valve 303, the cost of the sample analyzer 100 is reduced. Meanwhile, the first switch valve 302 is used for connecting a positive pressure source, and the second switch valve 303 is used for connecting a negative pressure source, so that the risk of cross contamination of the sample analyzer 100 can be reduced. Furthermore, in order to reduce the backflow of a small amount of foam into the second on-off valve 303, an isolation chamber 310 may be added between the second on-off valve 303 and the second pipeline 305, and the isolation chamber 310 may play a role of buffering.

Optionally, the reagent reservoir 30 further comprises a plurality of first branches 306 and a plurality of second branches 307. The plurality of first branches 306 are connected between the plurality of reagent reservoirs 301 and the first pipeline 304 in a one-to-one correspondence manner, and each first branch 306 is provided with a one-way valve 308. The plurality of second branches 307 are connected between the plurality of reagent pools 301 and the second pipeline 305 in a one-to-one correspondence manner, and each second branch 307 is provided with a check valve 308. In this embodiment, each of the first branches 306 is provided with a check valve 308, and each of the second branches 307 is provided with a check valve 308, so that the risk of cross contamination of the sample analyzer 100 can be reduced.

Optionally, the sample analyzer 100 further includes a third fluid valve set 83 and a second set of dosing pumps 94. The third liquid valve set 83 and the second quantitative pump set 94 are connected between the reagent tank set 30 and the reaction assembly 3. The third liquid valve group 83 is disposed in the second space 742 and below the reagent tank group 30. The third valve set 83 includes at least two valves. The third valve set 83 is used to coordinate the process of filling the reagent pool 30 into the reaction assembly 3. The second dosing pump group 94 includes at least two dosing pumps. The second quantitative pump unit 94 is used for quantitatively inputting the reagents in the reagent pool 30 into the reaction assembly 3. The second fixed displacement pump 93 may be disposed in the second space 742 below the third valve group 83.

Optionally, the sample analyzer 100 further includes a plurality of third pipes 831 connected between the third valve set 83 and the reaction module 3. The single third pipe 831 includes a first portion 8311, a connecting portion 8312, and a second portion 8313 connected in sequence. The first portion 8311 is connected to the third valve block 83. The second portion 8313 is connected to the reaction module 3, and the reaction module 3 is located below the third valve group 83. A first height difference is formed between both ends of the first portion 8311, a second height difference is formed between both ends of the second portion 8313, and the connection portion 8312 serves to prevent air bubbles from entering the first portion 8311 from the second portion 8313. Wherein the volume of the first portion 8311 may be smaller than the volume of the fixed displacement pumps in the second fixed displacement pump group 94.

In this embodiment, since the height difference between the third valve group 83 and the reaction module 3 is divided into the first height difference and the second height difference, and the values of the first height difference and the second height difference are both small, the risk of bubble accumulation in each of the first portion 8311 and the second portion 8313 can be reduced, and the connection portion 8312 can prevent bubbles from entering the first portion 8311 from the second portion 8313, and further reduce the risk of bubble accumulation in the first portion 8311, so that the problem of bubble accumulation caused by a single large height difference between the third valve group 83 and the reaction module 3 can be avoided, and bubbles in the third pipeline 831 can be removed as clean as possible.

Alternatively, as shown in fig. 13A to 13D, the connection portion 8312 may be a horizontal line, an inclined line, a loop line, or a check valve. When the connection portion 8312 is an inclined line (as shown in fig. 13B), the height of the end of the connection portion 8312 connected to the first portion 8311 is lower than the height of the end of the connection portion 8312 connected to the first portion 8311.

Optionally, as shown in fig. 13E, the connection portion 8312 may also be a two-way valve, when the two-way valve is powered on and opened for communication, the third liquid valve set 83 fills liquid into the reaction assembly 3, when liquid filling is finished, the two-way valve is powered off and closed for cutting off, and a small amount of bubbles in the liquid pass through the valve and are accumulated in the second portion 8313; when liquid is added to the reaction assembly 3 next time by the third liquid valve group 83, the bubbles in the second portion 8313 are discharged to the reaction assembly 3, and the circulation is performed in sequence, so that a large amount of bubbles cannot be accumulated in the third pipeline 831.

Optionally, a first reagent pool of the plurality of reagent pools 301, which is farthest from the first on-off valve 302, stores a diluent. Since the diluent has little influence on the reagent (e.g., hemolytic agent) in the other reagent cell, even if a small amount of the diluent flows back into the other reagent cell 301, the influence on the measurement is not great. Meanwhile, since some low-mix models do not have the first reagent reservoir for storing the diluent, disposing the first reagent reservoir at the end also facilitates closing the first reagent reservoir.

Optionally, the sample analyzer 100 further comprises a second gas valve block 102. The second air valve set 102 connects the reservoir set 20 and the reagent set 30, and the second air valve set 102 is disposed in the second space 742 and between the reagent set 30 and the first side plate 711. The second valve set 102 includes at least two valves. The second valve block 102 may be used to assist in coordinating the flow path of the reservoir stack 20 and the reagent stack 30. The second valve block 102 may also be used to assist in coordinating the actions of the first and second dosing pump groups 92, 94. The second valve group 102 may be disposed at a higher position in the second space 742 to satisfy a gas-liquid isolation requirement. The first on-off valve 302 and the second on-off valve 303 may also be disposed within the second valve block 102.

Optionally, the sample analyzer 100 further includes a reagent connector 309 and a fourth valve block 84. The reagent connector 309 is fixed to the second side plate 712 to facilitate piping connection, and the reagent connector 309 is used to input a reagent into the reagent reservoir pack 30. The fourth valve block 84 is connected between the reagent connector 309 and the reagent reservoir 30. The fourth set of valves 84 includes at least two valves. The fourth valve set 84 is used to coordinate the filling of the reagent reservoir set 30 with reagent.

Optionally, the sample analyzer 100 further includes a photo-coupling detection component 3010. The optical coupling detection component 3010 is connected between the reagent connector 309 and the fourth liquid valve group 84, and the optical coupling detection component 3010 is located below the fourth liquid valve group 84. The optical coupling detection component 3010 is used for detecting whether bubbles exist in a pipeline for transmitting reagents.

Referring to fig. 1 to 8, as an alternative embodiment, the reaction assembly 3 includes a first reaction chamber 31, a second reaction chamber 32, a third reaction chamber 33 and a fourth reaction chamber 34. The first reaction cell 31 is used for forming a first solution to be detected for detecting Hemoglobin (HGB) count. The second reaction chamber 32 is used for forming a second test solution for detecting the white blood cell count. The third reaction chamber 33 is used to form a third test solution for detecting a White Blood Cell (WBC) classification. The fourth reaction chamber 34 is used to form a fourth test solution for detecting Red Blood Cell (RBC) count.

Optionally, the detection assembly 4 further includes a first detector and a second detector. The first detector is arranged in the first reaction tank 31 and used for detecting the first solution to be detected by a photoelectric colorimeter method. The second detector is arranged in the fourth reaction tank 34 and is used for detecting the fourth liquid to be detected by an electrical impedance method.

Alternatively, the first reaction tank 31, the second reaction tank 32, the third reaction tank 33, and the fourth reaction tank 34 are sequentially arranged in a direction from the second end 732 to the first end 731 of the cross beam 73. The second test solution can also be used to detect nucleated red blood cell classification and basophil classification. Since the second test solution is measured the most times and the second reaction cell 32 performs the distribution of the biological sample in preference to the third reaction cell 33, the second reaction cell 32 is disposed closer to the second end 732 than the third reaction cell 33.

Optionally, the reaction assembly 3 further includes a fifth reaction cell 35, the fifth reaction cell 35 is configured to form a fifth solution to be detected for detecting reticulocyte (Ret) count, and the fifth reaction cell 35 is disposed between the third reaction cell 33 and the fourth reaction cell 34. Since the fifth reaction cell 35 is used less frequently or even not used, the fifth reaction cell 35 is disposed closer to the first end 731 than the second reaction cell 32 and the third reaction cell 33.

Optionally, the sample analyzer 100 further includes a first liquid valve 85 and a third quantitative pump 95, the first liquid valve 85 is connected between the first reaction tank 31 and the third quantitative pump 95, and the first liquid valve 85 and the third quantitative pump 95 are both disposed in the first space 741 and located below the liquid level of the first reaction tank 31. Since the first liquid valve 85 and the third quantitative pump 95 are located below the liquid surface of the first reaction cell 31, the interior of a pipe connecting the first liquid valve 85 and the third quantitative pump 95 for adding a reagent to the first reaction cell 31 is always in a positive pressure state, and bubbles can be prevented from being generated due to ventilation of the pipe. Meanwhile, the first liquid valve 85 and the third quantitative pump 95 are both disposed near the first reaction tank 31, which can shorten the length of the pipeline, so that the liquid in the pipeline can be completely refreshed after each measurement, thereby preventing bubbles from accumulating in the pipeline.

Referring also to fig. 1-14, as an alternative embodiment, the sample analyzer 100 further includes a flow cell 41 and a second syringe 42. The flow chamber 41 and the second syringe 42 are part of the detection assembly 4. The detection assembly 4 further comprises a third detector disposed at the outlet of the flow chamber 41 for detecting the liquid to be detected (e.g. the second liquid to be detected and/or the third liquid to be detected and/or the fifth liquid to be detected) by an optical detection method. The flow chamber 41 is provided in the first space 741 and located above the cross member 73, and the second syringe 42 is provided in the housing 71 and located below the flow chamber 41. The second syringe 42 may be used to push the test fluid preparation section into the flow chamber 41 for testing. The second syringe 42 is disposed below the flow chamber 41 to prevent generation of bubbles.

Optionally, the sample analyzer 100 further includes a seventh valve block 86. The seventh valve group 86 is connected between the flow chamber 41 and the first reservoir 201 for storing sheath fluid. Seventh valve set 86 is positioned adjacent to flow chamber 41 (e.g., below flow chamber 41) to facilitate connection while making full use of space. The seventh fluid valve set 86 includes at least two fluid valves.

Alternatively, the flow chamber 41 is provided in an upper region of the first space 741. For example, the flow chamber 41 may be provided between the gas tank group 11 and the first side plate 711.

Optionally, the sample analyzer 100 further comprises a third spacer 723. The third partition 723 is disposed in the first space 741 and connected between the first partition 721 and the third side plate 713, the flow chamber 41 is disposed above the third partition 723, and the air pump 12 is disposed below the third partition 723. In this case, the flow chamber 41 and the air pump 12 are respectively disposed at upper and lower sides of the third partition 723, and interference with each other can be reduced. The third partition 723 is disposed opposite to the top plate 715.

Referring to fig. 14, in one embodiment, the reaction assembly 3 includes a second reaction cell 32, a third reaction cell 33, and a fifth reaction cell 35. The second reaction tank 32 is used for forming a second solution to be tested for detecting the white blood cell count, the third reaction tank 33 is used for forming a third solution to be tested for detecting the white blood cell classification, and the fifth reaction tank 35 is used for forming a fifth solution to be tested for detecting the reticulocyte count. The sample analyzer 100 further comprises a fourth conduit 411, the flow chamber 41 is connected to the first access point 4111 of the fourth conduit 411, the second reaction cell 32 is connected to the second access point 4112 of the fourth conduit 411, the third reaction cell 33 is connected to the third access point 4113 of the fourth conduit 411, the fifth reaction cell 35 is connected to the fourth access point 4114 of the fourth conduit 411, and the first access point 4111, the second access point 4112, the third access point 4113 and the fourth access point 4114 are sequentially arranged on the fourth conduit 411. The distance between the second access point 4112 and the first access point 4111 is the smallest because the liquid to be measured in the second reaction chamber 32 needs to be measured in a large variety and the distribution order of the biological samples is advanced. Since the fifth reaction tank 35 is frequently used or even not used, the distance between the fourth access point 4114 and the first access point 4111 is maximized.

Optionally, the sample analyzer 100 further comprises a pinch-off valve set 50 and a third air valve set 87 for controlling the pinch-off valve set 50. The pressure shut-off valve set 50 is connected between the flow chamber 41 and the reaction block 3. The pressure-break valve set 50 is driven by air pressure (for example, by the first positive pressure in the first air storage tank 111), so that the risk of contamination of the liquid to be tested flowing from the reaction module 3 to the flow chamber 41 by the pressure-break valve set 50 can be reduced. The pressure shut-off valve set 50 is disposed close to the flow chamber 41 to shorten the length of a pipeline for connecting the pressure shut-off valve set 50 and the flow chamber 41, and reduce the preparation amount of the liquid to be measured. The third air valve set 87 is disposed in the first space 741 and below the reaction module 3. After the third air valve group 87 is arranged close to the press-off valve group 50, the length of an air pipe for connecting the third air valve group 87 with the press-off valve group 50 can be shortened, so that the flow resistance is reduced, and the air consumption is reduced.

Referring to fig. 1 to 15, as an alternative embodiment, the waste liquid treatment component 5 of the sample analyzer 100 is mounted on the second partition 722 and located in the second space 742. The waste liquid treatment assembly 5 comprises a first waste liquid pool 51, a second waste liquid pool 52, a liquid pump 53 and a fifth liquid valve group 88 which are arranged at intervals. The first waste reservoir 51 and the liquid pump 53 are located below the fifth valve block 88, and the second waste reservoir 52 is located between the fifth valve block 88 and the second side plate 712. A negative pressure environment is formed in the first waste liquid tank 51, and is used for collecting most of waste liquid of the sample analyzer 100. The second waste liquid pool 52 is connected to the atmosphere for collecting waste liquid discharged by positive pressure driving (for example, waste liquid flowing out from the outlet of the flow chamber 41). The second waste liquid pool 52 is connected to the first waste liquid pool 51, the first waste liquid pool 51 is connected to the second waste liquid pool 52, and the liquid pump 53 is connected to the first waste liquid pool 51. The waste liquid in the second waste liquid tank 52 enters the first waste liquid tank 51 and is discharged outside the machine by the liquid pump 53. The volume of the first waste liquid pool 51 may be larger than the volume of the second waste liquid pool 52. The fifth valve set 88 includes at least two valves for coordinating the actions of the waste liquid collection and discharge of the waste liquid treatment assembly 5.

Optionally, as shown in fig. 16, in another embodiment, the second waste liquid pool 52 may also solve the problem of foam overflow without using the liquid level sensor 54 and the delay control unit 61, an optical coupler detection sensor 62 may be disposed on the connection pipeline 55 between the second waste liquid pool 52 and the first waste liquid pool 51, when the second waste liquid pool 52 discharges liquid to the first waste liquid pool 51, the optical coupler detection sensor 62 starts detecting, and when it is detected that a signal in the optical coupler changes from liquid to bubbles, the second liquid valve 89 is controlled to stop discharging liquid, at this time, a part of the connection pipeline 55 is foam, a part of the connection pipeline is liquid, and a part of the foam in the second waste liquid pool is discharged, so as to avoid continuous foam accumulation in the second waste liquid pool 52.

Optionally, the waste liquid treatment assembly 5 further includes a connecting pipeline 55, a second liquid valve 89, a liquid level sensor 54, and a delay controller 61. The connection pipe 55 is connected between the second waste liquid pool 52 and the first waste liquid pool 51. The second hydraulic valve 89 is provided on the connecting line 55. The liquid level sensor 54 is disposed in the second waste liquid tank 52, and the liquid level sensor 54 is configured to detect a liquid level height of the waste liquid in the second waste liquid tank 52. The delay controller 61 is coupled to the liquid level sensor 54 and the second liquid valve 89, and the delay controller 61 is configured to delay a preset time to cut off the second liquid valve 89 when the liquid level is reduced to a preset value, so that part of the connecting pipeline 55 is filled with liquid and part of the connecting pipeline is filled with gas. The second fluid valve 89 may be one of the fifth set of fluid valves 88. The second liquid valve 89 can also adopt a pressure-break valve driven by air pressure so as to avoid the second liquid valve 89 from being blocked due to excessive impurities in waste liquid, thereby causing the second liquid valve 89 to be in failure. The delay controller 61 may be formed in the controller 6. The connecting pipe 55 (e.g., a rubber pipe) between the first waste liquid pool 51 and the second waste liquid pool 52 is long. The preset value is equal to zero or close to zero.

In this embodiment, when the first waste liquid pool 51 needs to extract the waste liquid in the second waste liquid pool 52, the second liquid valve 89 communicates the first waste liquid pool 51 with the second waste liquid pool 52, and the waste liquid in the second waste liquid pool 52 is extracted into the first waste liquid pool 51 under the action of the pressure difference. When the liquid level is reduced to the preset value, after delaying for a preset time, the delay control unit controls the second liquid valve 89 to disconnect the second waste liquid tank 52 from the first waste liquid tank 51, so that the waste liquid in the second waste liquid tank 52 is drained, but about half of the liquid in the connecting pipeline 55 is not drained (for preventing the first waste liquid tank 51 from being communicated with the atmosphere or the positive pressure source through the second waste liquid tank 52), and the other half of the liquid is foam, so that when the first waste liquid tank 51 pumps the waste liquid in the second waste liquid tank 52, a part of the foam in the second waste liquid tank 52 is drained (at least including a part entering the pipeline), thereby avoiding continuous accumulation of the foam in the second waste liquid tank 52, and solving the problem of foam overflow of the second waste liquid tank 52.

Optionally, the waste liquid disposal assembly 5 further comprises another liquid pump for discharging waste liquid generated by washing the swab to the first waste liquid tank 51.

Referring to fig. 1-15, as an alternative embodiment, the sample analyzer 100 further includes a cover plate 76. The cover plate 76 is located on a side of the first side plate 711 away from the second side plate 712, and the cover plate 76 is fastened to the first side plate 711 to form a third space 743. The cover 76 is pivotally or snap-fit connected to the first side plate 711.

Optionally, the sample analyzer 100 further comprises a dye assembly 60, wherein the dye assembly 60 is located in the third space 743. The dyes in the dye assembly 60 may be used to participate in a biological sample processing process. Because less dye is required per measurement and the dye is consumed slowly, a reservoir for storing dye need not be provided within the sample analyzer 100. The dye assembly 60 is disposed in the third space 743, so that the dye bag in the dye assembly 60 can be quickly and conveniently replaced by rotating or detaching the cover plate 76.

The dye assembly 60 includes a dye bag set 601, a third dosing pump set 96 and a sixth fluid valve set 89, the third dosing pump set 96 and the sixth fluid valve set 89 being located above the dye bag set 601. The dye bag set 601 includes at least two dye bags. The third dosing pump group 96 includes at least two dosing pumps. The sixth fluid valve group 89 includes at least fluid valves. The third dosing pump group 96 and the sixth valve group 89 are used to coordinate the dispensing action of the dye bag set 601.

Optionally, the sample analyzer 100 further includes a pre-heating assembly 70. The preheating assembly 70 is installed on the first side plate 711 and located in the third space 743.

Referring to fig. 1 to 9, as an alternative embodiment, the sample analyzer 100 further includes a sample introduction platform 80. The sample feeding platform 80 is located on one side of the first side plate 711 far away from the second side plate 712 and below the cross beam 73. The sample introduction platform 80 is used for placing and transporting test tubes containing biological samples.

Referring to fig. 1 to 15, as an alternative embodiment, a fourth space 744 is formed between the first partition 721 and the second partition 722. The fourth space 744 is used for routing the circuit of the sample analyzer 100. Components (e.g., dosing pumps, gas valves, liquid valves, etc.) of the sample analyzer 100 that need to be driven by electricity can be mounted on the first and

second partitions

721, 722.

Optionally, the sample analyzer 100 further comprises a fourth diaphragm 724. The periphery of the fourth partition 724 is connected to the first side plate 711, the second side plate 712, the third side plate 713, and the fourth side plate 714 and is located above the fourth space 744, and the fourth partition 724 is used for carrying a circuit board and components. The fourth partition 724 is disposed opposite to the top plate 715 and between the top plate 715 and the bottom plate 716. The controller 6 may be disposed on the fourth partition 724.

The fourth diaphragm 724 includes a fixing portion 7241 and a movable portion 7242 rotatably coupled to the fixing portion 7241, and the movable portion 7242 is configured to cover or open a portion of the fourth space 744. By rotating the movable portion 7242, the fourth space 744 can be quickly divided, so that the wiring and/or the components in the fourth space 744 can be maintained conveniently.

The sample analyzer of this application embodiment has components such as sampling subassembly, reaction assembly, determine module, waste liquid treatment subassembly and drive assembly to and the pipeline of electricity, gas, liquid between the subassembly, wherein the drive on liquid way is gas drive, and the power supply comes from the air pump that is located the inside of analysis appearance, cooperates the gas holder of a plurality of different pressures, constitutes the main power source on whole analysis appearance liquid way, can guarantee the performance requirement, again can reduce cost. The sample analyzer provided by the embodiment of the application has the advantages that the position relation of each component of the sample analyzer is reasonable, the electric pipelines, the gas pipelines and the liquid pipelines among the components are designed, the structural layout is reasonable, the space is utilized to the greatest extent, the size is small and the cost is low on the premise that the design requirements of the sample analyzer on multiple parameters and high speed are met.

The above embodiments of the present invention are described in detail, and the principle and the implementation of the present invention are explained by applying specific embodiments, and the above description of the embodiments is only used to help understanding the method of the present invention and the core idea thereof; meanwhile, for a person skilled in the art, according to the idea of the present invention, there may be variations in the specific embodiments and the application scope, and in summary, the content of the present specification should not be construed as a limitation to the present invention.

Claims

1. A sample analyzer, comprising:

the reaction assembly is accommodated in the first space and is positioned below the cross beam;

a sampling assembly comprising a sampler mounted on the beam and movable between the first and second ends; and

a controller for controlling a workflow of the sample analyzer.

2. The sample analyzer of claim 1 further comprising a second partition connected between the first side plate and the second side plate, the second partition and the third side plate forming a second space therebetween.

3. The sample analyzer of claim 2 wherein the first space is larger than the second space.

4. The sample analyzer of claim 2 wherein the sampling assembly further comprises a first fluid valve block mounted to the second partition, a hydraulic sensor, and a first syringe, the first fluid valve block being disposed in the second space, the first syringe and the hydraulic sensor being disposed in the second space and below the first fluid valve block.

5. The sample analyzer of claim 1 further comprising a drive assembly for driving a flow path in the sample analyzer, the drive assembly being located within the first space.

6. The sample analyzer of claim 5, wherein the driving assembly comprises a gas tank set disposed in the first space and a gas pump connected to the gas tank set for establishing positive and negative pressures for the gas tank set.

7. The sample analyzer of claim 6 further comprising a pressure sensing plate, wherein the distance between the set of gas tanks and the first side plate is greater than the distance between the set of gas tanks and the second side plate, wherein the pressure sensing plate is disposed between the set of gas tanks and the second side plate, and wherein the pressure sensing plate is configured to sense the pressure of the set of gas tanks.

8. The sample analyzer of claim 6, wherein the set of gas tanks includes a first gas tank and a second gas tank, the air pump establishing a first positive pressure within the first gas tank and the air pump establishing a first negative pressure within the second gas tank.

9. The sample analyzer of claim 8 wherein the set of gas tanks further includes a third gas tank connected to the first gas tank such that the first positive pressure establishes a second positive pressure within the third gas tank and a fourth gas tank connected to the first gas tank or the third gas tank such that the first positive pressure or the second positive pressure establishes a third positive pressure within the fourth gas tank, the third positive pressure being different from the second positive pressure.

10. The sample analyzer of claim 8, further comprising a fifth air reservoir disposed in the first space below the air pump, the fifth air reservoir being connected to the second air reservoir such that the first negative pressure creates a second negative pressure in the fifth air reservoir.

11. The sample analyzer of any one of claims 6-10, further comprising a pressure build-up pipeline, wherein a first end of the pressure build-up pipeline is connected to the outlet of the air pump, a second end of the pressure build-up pipeline is connected to the set of air storage tanks, and the pipeline extends from the first end to the second end, and then runs downward and then upward.

12. The sample analyzer of any of claims 6-10, wherein a float is disposed in the reservoir set, and the float is configured to alarm when liquid is introduced into the reservoir set.

13. The sample analyzer of any of claims 6-10, further comprising a first set of gas valves for controlling the pressurization of the set of gas reservoirs, the first set of gas valves being located in the first space.

14. The sample analyzer of any one of claims 6-10, further comprising a reservoir set disposed in the first space and below the reservoir set, and a second valve set for controlling filling and priming of the reservoir set, the second valve set being disposed between the first partition and the reservoir set.

15. The sample analyzer of claim 14, wherein the reservoir set comprises a first reservoir and a second reservoir, the sample analyzer further comprising a third syringe for filling the first reservoir with a liquid, the third syringe being positioned between the first spacer and the first reservoir, and a first dosing pump set connected between the second reservoir and the reaction assembly.

16. The sample analyzer of claim 15 wherein the reservoir set further comprises a second dosing pump connected between the first dosing pump set and the second reservoir for providing a backup liquid for the reaction assembly.

17. The sample analyzer of claim 14 further comprising a cut-out plate pivotally connected to the second side plate and positioned between the first divider and the fourth side plate, the cut-out plate configured to receive the reservoir.

18. The sample analyzer of claim 2 further comprising a reagent reservoir for storing reagents involved in processing the biological sample, the reagent reservoir being mounted to the second partition and located in the second space.

19. The sample analyzer of claim 18 wherein the set of reagent cells includes a plurality of reagent cells, the sample analyzer further comprising a first on-off valve for connecting a positive pressure source, a second on-off valve for connecting a negative pressure source, a first tubing connected between the plurality of reagent cells and the first on-off valve, and a second tubing connected between the plurality of reagent cells and the second on-off valve.

20. The sample analyzer of claim 19 wherein the reagent reservoir further comprises a plurality of first branches and a plurality of second branches, the plurality of first branches are connected between the plurality of reagent reservoirs and the first pipeline in a one-to-one correspondence, each first branch is provided with a one-way valve, the plurality of second branches are connected between the plurality of reagent reservoirs and the second pipeline in a one-to-one correspondence, and each second branch is provided with a one-way valve.

21. The sample analyzer of any of claims 18-20, further comprising a third set of fluid valves and a second set of dosing pumps, the third set of fluid valves and the second set of dosing pumps being connected between the set of reagent cells and the reaction module, the third set of fluid valves being disposed in the second space and below the set of reagent cells.

22. The sample analyzer of claim 21 further comprising a plurality of third conduits connected between the third set of fluid valves and the reaction assembly, wherein a single third conduit comprises a first portion, a connecting portion and a second portion connected in sequence, the first portion is connected to the third set of fluid valves, the second portion is connected to the reaction assembly, the reaction assembly is located below the third set of fluid valves, a first height difference is formed between two ends of the first portion, a second height difference is formed between two ends of the second portion, and the connecting portion is configured to prevent air bubbles from entering the first portion from the second portion.

23. The sample analyzer of claim 22 wherein the volume of the first portion is less than the volume of the fixed displacement pumps in the second set of fixed displacement pumps.

24. The sample analyzer of any one of claims 18-20, further comprising a second set of air valves and a reservoir set, wherein the second set of air valves connects the reservoir set and the reagent set, and the second set of air valves is disposed in the second space between the reagent set and the first side plate.

25. The sample analyzer of any of claims 18-20, further comprising a reagent connector affixed to the second side plate for inputting a reagent into the reagent reservoir, and a fourth set of fluid valves connected between the reagent connector and the reagent reservoir.

26. The sample analyzer of claim 25 further comprising an optocoupler detection assembly connected between the reagent connector and the fourth fluid valve set, the optocoupler detection assembly being located below the fourth fluid valve set.

27. The sample analyzer of claim 1, wherein the reaction assembly includes a first reaction cell for forming a first test solution for detecting hemoglobin counts, a second reaction cell for forming a second test solution for detecting white blood cell counts, a third reaction cell for forming a third test solution for detecting white blood cell classifications, and a fourth reaction cell for forming a fourth test solution for detecting red blood cell counts.

28. The sample analyzer of claim 27 wherein the first reaction cell, the second reaction cell, the third reaction cell, and the fourth reaction cell are arranged in sequence in a direction from the second end toward the first end of the beam.

29. The sample analyzer of claim 28 wherein the reaction assembly further includes a fifth reaction cell for forming a fifth test solution for detecting reticulocyte count, the fifth reaction cell being disposed between the third reaction cell and the fourth reaction cell.

30. The sample analyzer of any of claims 27-29 wherein the second test solution is further used for detecting nucleated red blood cell classification and basophil classification.

31. The sample analyzer of any one of claims 27-29, further comprising a first liquid valve and a third quantitative pump, wherein the first liquid valve is connected between the first reaction cell and the third quantitative pump, and the first liquid valve and the third quantitative pump are both disposed in the first space and below the liquid level of the first reaction cell.

32. The sample analyzer of claim 1 further comprising a flow chamber disposed in the first space above the cross beam and a second syringe disposed in the housing below the flow chamber.

33. The sample analyzer of claim 32 further comprising a third partition disposed in the first space and connected between the first partition and the third side plate, the flow chamber disposed above the third partition; the sample analyzer further comprises an air pump arranged in the first space, and the air pump is arranged below the third partition plate.

34. The sample analyzer of claim 32, wherein the reaction assembly includes a second reaction cell for forming a second test solution for detecting white blood cell count, a third reaction cell for forming a third test solution for detecting white blood cell classification, and a fifth reaction cell for forming a fifth test solution for detecting reticulocyte count;

35. The sample analyzer of any of claims 32-34, further comprising a pinch-off valve set coupled between the flow chamber and the reaction block, and a third air valve set controlling the pinch-off valve set, the third air valve set disposed in the first space and below the reaction block.

36. The sample analyzer of any of claims 2-10, further comprising a waste disposal assembly mounted to the second partition and located in the second space, the waste disposal assembly including first and second waste reservoirs spaced apart from each other, a liquid pump, and a fifth valve set, the first and second waste reservoirs located below the fifth valve set, the second waste reservoir located between the fifth valve set and the second side plate.

37. The sample analyzer of claim 36, wherein the waste liquid disposal assembly further comprises a connection pipeline, a second liquid valve, a liquid level sensor and a time delay controller, the connection pipeline is connected between the second waste liquid pool and the first waste liquid pool, the second liquid valve is disposed on the connection pipeline, the liquid level sensor is disposed in the second waste liquid pool, the liquid level sensor is used for detecting a liquid level height of waste liquid in the second waste liquid pool, the time delay controller is coupled with the liquid level sensor and the second liquid valve, and the time delay controller is used for delaying a preset time to cut off the second liquid valve when the liquid level height is reduced to a preset value, so that a part of the connection pipeline is liquid and a part of the connection pipeline is gas.

38. The sample analyzer of claim 36, wherein the waste liquid disposal assembly further comprises a connection pipeline, a second liquid valve, and an optical coupling detection sensor, the connection pipeline is connected between the second waste liquid tank and the first waste liquid tank, the second liquid valve is disposed on the connection pipeline, the optical coupling detection sensor is disposed on the connection pipeline, and when the optical coupling detection sensor detects that gas is generated in the connection pipeline, the second liquid valve stops working so that part of the connection pipeline is liquid and part of the connection pipeline is gas.

39. The sample analyzer of any one of claims 1-10 further comprising a cover plate on a side of the first side plate remote from the second side plate, the cover plate engaging the first side plate to form a third space, and a dye assembly in the third space.

40. The sample analyzer of claim 39 wherein the dye assembly includes a dye bag set, a third set of dosing pumps, and a sixth set of fluid valves, the third set of dosing pumps and the sixth set of fluid valves being positioned above the dye bag set.

41. The sample analyzer of any one of claims 1-10, further comprising a cover plate on a side of the first side plate away from the second side plate, the cover plate engaging the first side plate to form a third space, and a pre-heating assembly mounted on the first side plate and located in the third space.

42. The sample analyzer of any one of claims 1-10, wherein a fourth space is formed between the first partition and the second partition, and the fourth space is used for routing the circuit of the sample analyzer.

43. The sample analyzer of claim 42 further comprising a fourth divider having a perimeter connecting the first side panel, the second side panel, the third side panel, and the fourth side panel and located above the fourth space, the fourth divider adapted to carry a circuit board and components;