CN109991430A - Sample analyser and method of sample analysis - Google Patents
Sample analyser and method of sample analysis Download PDFInfo
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- CN109991430A CN109991430A CN201711487635.9A CN201711487635A CN109991430A CN 109991430 A CN109991430 A CN 109991430A CN 201711487635 A CN201711487635 A CN 201711487635A CN 109991430 A CN109991430 A CN 109991430A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1048—General features of the devices using the transfer device for another function
- G01N2035/1053—General features of the devices using the transfer device for another function for separating part of the liquid, e.g. filters, extraction phase
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The application discloses a kind of sample analyser, comprising: sampling unit, for acquiring blood sample;Divide blood valve, the adjacent sampling unit, the blood sample for acquiring sampling unit carries out Quantitative Separation and distributes simultaneously;Reaction member, for making the blood sample for dividing blood valve to distribute form test solution, the reaction member includes multiple reaction tanks, and the multiple reaction tank is all connected with the top for dividing blood valve and divide blood valve described in;Detection unit, the adjacent reaction member, including multiple test sections, for detecting the test solution of the reaction member generation to form detection information;And reagent unit, reagent needed for being used to provide the described each unit of sample analyser;Gas circuit unit, for providing positive pressure and negative pressure to the sample analyser.Further relate to a kind of method of sample analysis.The sample analyser of the application is rationally distributed, measurement is accurate quick.
Description
Technical field
The present invention relates to medical instruments field more particularly to a kind of sample analysers and method of sample analysis.
Background technique
With the increase of the diversified demand to cellanalyzer analytic function, the required portion being arranged of cellanalyzer
Part is more and more, so that cellanalyzer inner space is more nervous, increases the topology layout difficulty of cellanalyzer,
Also, it is diversified to need also to make taking a long time for detection, so that the test speed for leading to cellanalyzer is lower.
Summary of the invention
The embodiment of the present invention discloses a kind of faster sample analyser of test speed and method of sample analysis.
A kind of sample analyser, comprising: sampling unit, for acquiring blood sample;Divide blood valve, the adjacent sampling is single
Member, the blood sample for acquiring sampling unit carry out Quantitative Separation and distribute simultaneously;Reaction member, for blood valve point will to be divided
The blood sample matched makes to form test solution, and the reaction member includes multiple reaction tanks, and the multiple reaction tank is all connected with described
Divide blood valve and is located at the top for dividing blood valve;Detection unit, the adjacent reaction member, including multiple test sections, for examining
The test solution of the reaction member generation is surveyed to form detection information;Reagent unit is used to provide the described each list of sample analyser
The required reagent of member;Gas circuit unit, for driving the blood sample, test solution and reagent in each unit of the sample analyser
Between transfer;And control assembly, it is used for: controlling the sampling unit acquisition blood sample;Divide blood valve will be collected described in control
Blood sample carries out Quantitative Separation;Gas circuit cell operation is controlled to distribute the blood sample after Quantitative Separation simultaneously to described each anti-
Ying Chi, and control the reagent that reagent unit is provided and distribute to each reaction tank;It controls each prepared examination of reaction tank
Liquid is injected into the detection unit, and control will test required reagent and distribute to the detection unit;It is single to control the detection
Member detects the test solution and forms detection information.
A kind of method of sample analysis has sampling unit, divides blood valve, multiple reactions comprising steps of providing sample analyser
Pond, multiple test sections, reagent unit and gas circuit unit;Blood sample is acquired by sampling unit;By dividing blood valve that will collect
Blood sample carry out Quantitative Separation;By gas circuit unit and it is described divide blood valve to make Quantitative Separation after blood sample and meanwhile distribute
Extremely multiple reaction tanks, and the reagent for providing the reagent unit is distributed to the multiple reaction tank;By the multiple reaction tank
Prepared test solution is injected into corresponding test section, and reagent needed for detection that the reagent unit provides is distributed to each
The test section;The test solution is detected by each test section and forms detection information.
Sample of the present invention analyzer, by the multiple reaction tank be all connected with it is described divide blood valve and be located at described divide the upper of blood valve
Side makes the rationally distributed of sample analyser, and then has lesser energy consumption, less sample losses and detect speed faster;
And using dividing blood valve to distribute by blood sample Quantitative Separation and simultaneously, to also make measurement result more accurate and measuring speed
Comparatively fast.
Detailed description of the invention
It to describe the technical solutions in the embodiments of the present invention more clearly, below will be to needed in the embodiment
Attached drawing is briefly described, it should be apparent that, drawings in the following description are only some embodiments of the invention, for ability
For the those of ordinary skill of domain, without creative efforts, it can also be obtained according to these attached drawings other attached
Figure.
Fig. 1 is the block diagram of the sample analyser of first embodiment of the invention.
Fig. 2 is the positive stereoscopic schematic diagram of the sample analyser of first embodiment of the invention, wherein front shroud is not shown.
Fig. 3 is the stereoscopic schematic diagram of the right side of the sample analyser of first embodiment of the invention, wherein the right side plate
It is in the open state.
Fig. 4 is the stereoscopic schematic diagram of the left side of the sample analyser of first embodiment of the invention, wherein the left plate
It is in the open state.
Fig. 5 is the stereoscopic schematic diagram of the left side of the sample analyser of first embodiment of the invention, wherein the left plate
It is in close state, wherein left panel is not shown.
Fig. 6 is the stereoscopic schematic diagram of the left back side of the sample analyser of first embodiment of the invention.
Fig. 7 is the stereoscopic schematic diagram of the left front side of the sample analyser of first embodiment of the invention.
Fig. 8 is the stereoscopic schematic diagram in the forward right side face of the sample analyser of first embodiment of the invention.
Fig. 9 is the sampling unit of the sample analyser of first embodiment of the invention, divides blood valve, reaction member, detection unit
And the relevant schematic diagram of portion of reagent unit, the portion of reagent unit include hemolytic agent portion, reticulocyte determination dilution
Liquid portion and portion of diluent portion.
Figure 10 is the relevant schematic diagram in optics sheath fluid portion of the sample analyser of first embodiment of the invention.
Figure 11 is the relevant schematic diagram in impedance sheath fluid portion of the sample analyser of first embodiment of the invention.
Figure 12 is the relevant schematic diagram in diluent portion of the sample analyser of first embodiment of the invention.
Figure 13 is the relevant schematic diagram in fluorescent reagent portion of the sample analyser of first embodiment of the invention.
Figure 14 is the relevant schematic diagram of waste unit of the sample analyser of first embodiment of the invention.
Figure 15 is the first waste liquid pool of the sample analyser of first embodiment of the invention and the schematic diagram of portion of reagent unit,
The portion of reagent unit includes hemolytic agent liquid storage tank and reticulocyte determination dilution liquid storage tank.
Figure 16 is the first waste liquid pool of the sample analyser of another embodiment of the present invention and the schematic diagram of portion of reagent unit,
The portion of reagent unit includes hemolytic agent liquid storage tank and reticulocyte determination dilution liquid storage tank.
Figure 17 is the schematic diagram of the gas circuit unit of the sample analyser of first embodiment of the invention.
Figure 18 is the flow diagram of the method for sample analysis of second embodiment of the invention.
Specific embodiment
Below in conjunction with the attached drawing in technical solution of the present invention embodiment, technical solution in the embodiment of the present invention is carried out
It clearly and completely describes, it is clear that the described embodiment is only a part of the embodiment of the present invention, instead of all the embodiments.
Based on the embodiments of the present invention, obtained by those of ordinary skill in the art without making creative efforts all
Other embodiments shall fall within the protection scope of the present invention.
Please also refer to Fig. 1 to 13, the technical program embodiment provides a kind of sample analyser 100, the sample analysis
Instrument 100 includes a cabinet 1, and sampling unit 2 on the cabinet 1, divides blood valve 3, reaction member 4, detection unit 5, examination
Agent unit 6, waste unit 7, gas circuit unit 8 and control assembly 9.
As shown in Figure 1, the sampling unit 2 is for acquiring blood sample;The adjacent sampling unit 2 of described point of blood valve 3,
Blood sample for acquiring sampling unit 2 carries out Quantitative Separation and distributes simultaneously;The reaction member 4 will be for that will divide blood valve
The blood sample of 3 distribution makes to form test solution, and the reaction member 4 includes multiple reaction tanks, and the multiple reaction tank is all connected with
Described point of blood valve 3 is simultaneously located at the top for dividing blood valve 3;The adjacent reaction member 4 of the detection unit 5, including multiple inspections
Survey portion, the test solution that multiple reaction tanks for detecting the reaction member 4 generate is to form detection information;The reagent unit 6
Reagent needed for being used to provide the described each unit of sample analyser 100;The gas circuit unit 8 is used for the sample analyser
100 provide positive pressure and negative pressure to drive the blood sample, test solution and reagent to move between each unit of the sample analyser 100
It send;The control assembly 9 is used to control the workflow of the sample analyser 100 and handles the detection information to be formed point
Analyse result.
As shown in Fig. 2 to 8, the cabinet 1 includes a foreboard 11, one opposite back plate 12, one parallel with the foreboard 11
During openable and closable right side plate 13, an openable and closable left plate 14, one are set between the right side plate 13 and the left plate 14
Partition 15 and the upper spacer 16 for vertically connecting the middle partition 15, top plate 17 above upper spacer 16 are set to 1 bottom of cabinet
The bottom plate 18 in portion and front shroud 19 set on 11 front side of the foreboard are additionally provided with right panel 131, institute on the outside of the right side plate 13
It states and is additionally provided with left panel 141 on the outside of left plate 141;Wherein, the top plate 17, bottom plate 18, back plate 12, right panel 131, the left side
Plate 141 and front shroud 19 surround the shell to form the sample analyser 100,23 foreboard 11, right side plate 13, left plate 14,
Middle partition 15 and the upper spacer 16 are contained in the interior of shell.Wherein, user interface is additionally provided on the front shroud 19
191 carry out control operation for user;The left plate 14 and the right side plate 13 can be separately connected by hinge or pivot etc.
In in the left and right sides of the back plate 12 so as to 1 activity of the cabinet relatively, in order to which operator is left by rotation
Side plate 14 and/or the right side plate 13 and open the cabinet 1 and carry out the operation such as detecting.
As shown in Fig. 2, the sampling unit 2 is for acquiring blood sample;In the present embodiment, the sampling unit 2 includes
Puncture sampling needle portion 21, open sampling probe portion 22 and automatic sampling frame 23;The puncture sampling needle portion 21 includes puncturing sampling needle
211 and with the sampling needle driving assembly 212 that matches of puncture sampling needle 211, the sampling needle driving assembly 212 and puncture
Sampling needle 211 is located at the intermediate upper position of the foreboard 11, the puncture sampling needle 211 connect it is described divide blood valve 3, will adopt
The blood sample of collection divides blood valve 3 described in being supplied to;The open sampling probe portion 22 includes open sampling needle 221 and adopts with the opening
The swab component 222 that sample needle 221 matches, the open sampling needle 221 and swab component 222 are located at the right side of the foreboard 11
Upper position, the open sampling needle 221 connect it is described divide blood valve 3, the blood sample of acquisition is supplied to and described divides blood valve 3;
The automatic sampling frame 23 is platform extend from front side of the foreboard 11 and that bottom surface is flushed with the bottom plate 18, it is described from
Dynamic sample introduction frame 23 includes to automatically deliver part, for placing and automatically delivering blood sample to be detected to the puncture sampling needle portion
21 lower sections, are sampled for the puncture sampling needle portion 21.
Described point of blood valve 3 is used to the blood sample that sampling unit 2 acquires carrying out Quantitative Separation and distribute simultaneously;Described point
Blood valve 3 is set to the position of keeping right on the foreboard 11 and being located at the foreboard 11.In the present embodiment, as shown in figure 9, described point
It include that there are five channels, respectively reticulocyte determination (RET) channel 31, erythroblast analysis (NRBC) in blood valve 3
With channel 32, leukocyte analysis (DIFF) channel 33, hemoglobin analysis (HGB) channel 34 and red blood cell determination (RBC)
With channel 35, wherein be allocated respectively via five channels after blood sample Quantitative Separation.
For making the blood sample for dividing blood valve 3 to distribute to form test solution, the reaction member 4 wraps the reaction member 4
Include multiple reaction tanks and some pipelines relevant to the reaction tank, heating bath, valve, constant displacement pump etc..Wherein, the multiple
Reaction tank is respectively positioned on the foreboard 11, and is all connected with the top for dividing blood valve 3 and divide blood valve 3 described in, so that described
Multiple reaction tanks divide being closer for blood valve 3 with described, reduce the usage amount of blood sample and related reagent, and reduce pipeline
Carry pollution.
In the present embodiment, as shown in Fig. 2 and Fig. 9, the multiple reaction tank include optical analysis (WBC) with reaction tank 41,
HGB reaction tank 42 and RBC premixing pool 43;The WBC reaction tank 41 is three reaction tanks, respectively RET reaction tank
411, NRBC premixing pool 412 and DIFF reaction tank 413;Wherein, the RET reaction tank 411 is connected to the channel RET
31 and for blood sample is made to be formed detection reticulocyte count the first test solution, the NRBC with premixing pool 412 connect
Lead to the channel 32 channel NRBC the RBC and to form detection red blood cells count and leucocyte for making blood sample
The second test solution counted, the DIFF reaction tank 413 are connected to the channel 33 the DIFF and for blood sample to be made shape
At the third test solution of detection leukocyte differential count, the HGB reaction tank 42 is connected to the channel 34 the HGB and is used for blood sample
This production forms the 4th test solution of detection hemoglobin concentration, and the RBC premixing pool 43 is connected to the RBC and is used in combination with channel 35
In the 5th test solution that blood sample system is formed to detection red blood cell count(RBC).
RET reaction tank 411, NRBC premixing pool 412 and DIFF are respectively positioned on side by side with reaction tank 413 described divides blood
Above the left side of valve 3, the HGB reaction tank 42 is located above the right side for dividing blood valve 3, and the RBC is with premixing pool 43
Above the left side for dividing blood valve 3 and the WBC is more kept left with reaction tank 41.
As shown in Fig. 2,3 and Fig. 9, the detection unit 5 includes that WBC test section 51, HGB test section 52 and RBC are used
Test section 53;Wherein, the WBC adjacent WBC reaction tank 41 of test section 51, the HGB adjacent institute of test section 52
State HGB reaction tank 42, the RBC adjacent RBC premixing pool 43 of test section 53;The WBC test section 51 is used for
Detect the reticulocyte count in first test solution, red blood cells count and leucocyte meter in second test solution
Leukocyte differential count in the several and described third test solution, the HGB test section 52 are used to detect the blood in the 4th test solution
Hemoglobin concentration, the RBC test section 53 are used to detect the red blood cell count(RBC) in the 5th test solution.
Wherein, the first, second and third test solution that the WBC reaction tank 41 is formed passes through one and is connected to the WBC
With pushing away sample syringe 414 and the connection WBC test section 51 on pipeline between test section 51 and the WBC reaction tank 41
Sample-adding quantify pump assembly 415, inject the WBC in test section 51;The quantitatively pump assembly 415 that is loaded includes constant displacement pump
4151, the first quantitative pump control valve 4152 and the second quantitative pump control valve 4153, the described first quantitative pump control valve 4152 are connected in
For the WBC connected to it of constant displacement pump 4151 between reaction tank 41, the described second quantitative pump control valve 4153 is connected in constant displacement pump 4151
With can provide between the power source of positive/negative-pressure, in the present embodiment, that is, be connected between constant displacement pump 4151 and gas circuit unit 8, wherein dynamic
The positive/negative-pressure switching in power source drives the constant displacement pump 4151 that the WBC is quantitatively delivered to WBC with the test solution in reaction tank 41
With test section 51.
It should be noted that the subsequent sample-adding mentioned of the technical program embodiment or charge quantitative pump assembly all with it is described plus
It is similar that sample quantifies pump assembly 415, therefore, it is subsequent to be no longer described in detail.
The 5th test solution that the RBC premixing pool 43 is formed is connected to RBC test section 53 and the RBC by one
It is injected in RBC test section 53 with the sample syringe 431 that pushes away between premixing pool 43 on pipeline.
In the present embodiment, as shown in Figure 2,3, the RBC test section 52 and HGB test section 53 be all set in it is described before
On plate 11, and it is respectively positioned on the top for dividing blood valve 3, it is close that WBC test section 51 is set to 16 right sides on the upper spacer
The position of the foreboard 11;HGB reaction tank 42 and HGB test section 52 are located at the upper bottom in same pond
It sets;The position close to the foreboard 11 that sample syringe 414 is pushed away on the middle partition 15;It is described to push away sample syringe
431 are set to the lower right of RBC test section 53, in order to the exclusion of bubble in reagent cartridge.
Wherein, each WBC reaction tank 41 and WBC break valve with being additionally provided between test section 51, and the valve that breaks is set
It is placed in the front of reaction tank 41 corresponding WBC, for reducing the amount of sample preparation and convenient for cleaning;The RBC premix
Pond 43 and the RBC between test section 53 with also being provided with breaking valve.
Reagent needed for the reagent unit 6 is used to provide the described each unit of sample analyser 1;The reagent includes will
Blood sample makes to form test solution needed for reagent, required reagent and to sampling when being detected to the test solution
Unit 2, divide blood valve 3, reaction member 4, detection unit 5 etc. and carry out clean required reagent, etc..
In the present embodiment, the reagent unit 6 includes a hemolytic agent portion 61, and the hemolytic agent portion 61 is used for the multiple
Reaction tank provides hemolytic agent.
As shown in Fig. 1,2 and Fig. 9, the hemolytic agent portion 61 includes liquid storage tank, respectively leucocyte in three hemolytic agent machines
Liquid storage tank 611, erythroblast analysis liquid storage in hemolytic agent (LN hemolytic agent) machine in analysis hemolytic agent (LD hemolytic agent) machine
Liquid storage tank 613 in pond 612 and hemoglobin analysis hemolytic agent (LH hemolytic agent) machine;Wherein, liquid storage in the LD hemolytic agent machine
Pond 611 connects the channel DIFF 33 to connect DIFF reaction tank 413, for the DIFF reaction tank
413 provide LD hemolytic agent, and liquid storage tank 612 connects the channel channel NRBC 32 the RBC to even in the LN hemolytic agent machine
NRBC premixing pool 412 is connect, for providing LN hemolytic agent to NRBC premixing pool 412, in the LH hemolytic agent machine
Liquid storage tank 613 connects HGB reaction tank 42, for providing LH hemolytic agent to HGB reaction tank 42.
The hemolytic agent portion 61 further includes LD hemolytic agent preheating pond 614 and a LN hemolytic agent preheats pond 615, described
LD hemolytic agent preheating pond 614 and LN hemolytic agent preheating pond 615 are connected to liquid storage tank in the corresponding hemolytic agent machine
Between the corresponding channel for dividing blood valve 3, for heating LD and LN hemolytic agent.
The LD hemolytic agent preheating pond 614 and LN hemolytic agent preheating pond 615 are stored up in the corresponding hemolytic agent machine
Liquid storage tank 613 and the HGB are with being also respectively connected with a sample-adding between reaction tank 42 between liquid pool and in the LH hemolytic agent machine
Quantitative pump assembly 616, it is described to be loaded quantitative pump assembly 616 for the reagent quantitative in liquid storage tank in hemolytic agent machine to be delivered to
Corresponding reaction tank.Blood valve 3 described is divided with corresponding in LD hemolytic agent preheating pond 614 and LN hemolytic agent preheating pond 615
Channel between a check valve 617 is also respectively connected, also had in the channel because dividing blood valve 3 blood sample residual and also
It can fill and rush cleaning reagent, the check valve 617 is used to limit the reflux of the hemolytic agent in the channel for dividing blood valve 3, and then can be with
Prevent the cross contamination between reagent.
The reagent unit 6 further includes a reticulocyte determination dilution (DR dilution) portion 62, the DR dilution
Liquid portion 62 is used to provide DR dilution to RET reaction tank 411;DR dilution portion 62 includes in a DR dilution machine
Liquid storage tank 621, liquid storage tank 621 connects the channel RET 31 to connect the RET reaction tank in the DR dilution machine
411, for providing DR dilution to RET reaction tank 411;DR dilution portion 62 further includes that a DR dilution is pre-
Heating bath 622, DR dilution preheating pond 622 be connected in the DR dilution machine liquid storage tank 621 with it is corresponding described
RET is between channel 31, for heating DR dilution;Wherein, LD hemolytic agent preheating pond 614, LN hemolytic agent preheating
Pond 615 can be heated simultaneously with DR dilution preheating pond 622 using same device;The DR dilution preheating
Also a sample-adding is connected in pond 622 and DR dilution machine between liquid storage tank 621 and quantifies pump assembly 623, it is described to be loaded quantitative pump group
Part 623 is used to for the DR dilution in machine in liquid storage tank 621 being quantitatively transferred to the DR dilution of RET reaction tank 411;Institute
DR dilution preheating pond 622 is stated with the corresponding RET with a check valve 624 is also connected between channel 31, to limit
It states the reflux of the DR dilution in the channel RET 31 and prevents the cross contamination between reagent.
As shown in Figure 2 and Figure 3, liquid storage tank 611 in the LD hemolytic agent machine, liquid storage tank 612, LH haemolysis in LN hemolytic agent machine
In agent machine in liquid storage tank 613 and the DR dilution machine liquid storage tank 621 be set to side by side it is (only visible in Fig. 3 on the upper spacer 16
Liquid storage tank 613 in LH hemolytic agent machine, liquid storage tank has been blocked in other three machines), with position with higher, prevent from exporting
Bubble is generated, in the present embodiment, liquid storage tank is also arranged adjacent to WBC test section 51 in three hemolytic agent machines;It is described
LD hemolytic agent preheats pond 614, LN hemolytic agent preheating pond 615 and DR dilution preheating pond 622 side by side set on described
Close to the side of the back plate 12, (only visible LD hemolytic agent preheats pond 614, other two preheating pond quilts to foreboard 11 in Fig. 3
Shelter from), i.e., on rear side of foreboard 11, and it is located at the behind for dividing blood valve 3, divides the distance between blood valve 3 with described to shorten,
Prevent the excessive dissipation of heat;Multiple quantitatively pump assemblies 616,623 that are loaded are set to 12 front side of back plate, and position
It sets and is below the position for dividing blood valve 3, to reduce the generation of the bubble during sample-adding;The check valve 617,624 is set to
On the foreboard 11 and it is located at the right side for dividing blood valve 3.
Liquid storage tank 611 in the LD hemolytic agent machine, liquid storage tank 612 in LN hemolytic agent machine, liquid storage tank 613 in LH hemolytic agent machine
And liquid storage tank connects with the gas circuit unit 8 at least one machine in the DR dilution machine in liquid storage tank 621, in access institute
In the state of the negative pressure for stating gas circuit unit 8, liquid storage tank is used for the reagent barrel absorption reagent from outside machine and stores up at least one described machine
Deposit the reagent;In the state of with the disconnection of the negative pressure of the gas circuit unit 8, liquid storage tank is closed storage at least one described machine
Liquid pool, for liquid storage tank when supplying reagent to the reaction member 4, the consumption of reagent makes described at least one at least one described machine
Of short duration negative pressure is formed in a machine in liquid storage tank, so that liquid storage tank can also be used in the reagent from outside machine automatically at least one described machine
Bucket draws reagent to supplement the reagent of consumption, does not need to expend gas source again.
Liquid storage tank 611 in the LD hemolytic agent machine, liquid storage tank 612 in LN hemolytic agent machine, liquid storage tank 613 in LH hemolytic agent machine
And in the DR dilution machine liquid storage tank 621 volume it is smaller, be 100 milliliters hereinafter, to be easier to be contained in the sample point
Inside analyzer 100, and this volume meets the needs of agent delivery enough again.
As shown in Fig. 9 and Figure 12, the reagent unit 6 further includes diluent portion 65, and the diluent portion 65 is used for institute
State HGB test section reaction tank and RBC premixing pool and detection diluent be provided, and to the sampling unit 2, divide blood
Valve 3, reaction member 4 and detection unit 5 provide cleaning diluent.
In the present embodiment, the diluent portion 65 includes liquid storage tank 651 in a diluent machine.
As shown in figure 9, liquid storage tank 651 connects the channel HGB 34 to connect the HGB use in the diluent machine
Reaction tank 42, for providing diluent to HGB reaction tank 42, liquid storage tank 651 is also connected with described in the diluent machine
The channel RBC 35 is to connect RBC premixing pool 43, for providing diluent to RBC premixing pool 43.It is described dilute
Liquid storage tank 651 and the HGB are released in agent machine with liquid storage tank 651 and the RBC are used between channel 34 and in the diluent machine
It is also respectively connected with a sample-adding between channel 35 and quantifies pump assembly 652, for by the reagent quantitative in liquid storage tank 651 in diluent machine
Ground is delivered to corresponding reaction tank.
As shown in figure 12, liquid storage tank 651 is also connected with the two dilution entrances 36 for being divided to blood valve 3 in the diluent machine,
And then it can be connected to the sampling unit 2, and it is also connected with the pipeline (for example, shown in Figure 10) of the reaction member 4, it is dilute for providing
Release agent to the sampling unit 2, divide blood valve 3 and the pipeline of reaction member 4 to clean.The diluent portion 65 further includes one
Diluent heating bath 653, the diluent heating bath 653 is connected to the outlet of liquid storage tank 651 in the diluent machine, to institute
It states after the diluent that liquid storage tank 651 exports in diluent machine is heated and exports.Wherein, liquid storage tank 651 and institute in diluent machine
It states and is also connected with one between point blood valve 3 and pushes away sample syringe 654, the sample syringe 654 that pushes away to described for dividing blood valve 3 to inject institute
Diluent is stated to clean and described divide blood valve 3 and associated pipe.
In the present embodiment, liquid storage tank 651 is set on the right side plate 13 in the diluent machine;The diluent heating bath
653 are also set on the right side plate 13.
As shown in Fig. 3, Figure 10 and Figure 12, the reagent unit 6 further includes optics (FCM) sheath fluid portion 63, the FCM sheath fluid
Portion 63 is used to provide FCM sheath fluid to WBC test section 51.FCM sheath fluid portion 63 includes liquid storage tank 631 in a FCM machine,
Liquid storage tank 631 connects the WBC test section 51 in the FCM machine.FCM sheath fluid portion 63 further includes a sheath fluid FCM
Heating bath 632, the sheath fluid FCM heating bath 632 are connected to liquid storage tank 631 and the WBC test section in the sheath fluid FCM machine
Between 53, the sheath fluid FCM for that will be provided to WBC test section 53 is heated;As shown in figure 12, liquid storage in the FCM machine
The connection of pond 631 one charges quantitative pump assembly 633, for filling in liquid storage tank 631 from the reagent barrel outside machine is quantitative into the FCM machine
Fill FCM sheath fluid.
In the present embodiment, as shown in figure 3, liquid storage tank 631 is set on the right side plate 16 and is located in the sheath fluid FCM machine
The side of the diluent liquid storage tank;The sheath fluid FCM heating bath 632 is set to the back of the foreboard 11, and close to the WBC
It is arranged with test section 51, to shorten and the WBC the distance between test section 51, reduction pipeline heat dissipation;Described charge is determined
Pump assembly 633 is measured to be set on the right side plate 13.
As shown in Fig. 3 and Figure 11, the reagent unit 6 further includes impedance (SCI) sheath fluid portion 64, SCI sheath fluid portion 64
For providing SCI sheath fluid to RBC test section 53.
SCI sheath fluid portion 64 includes liquid storage tank 641 and a buffer pool 642 in a SCI machine.
Liquid storage tank 641 connects RBC test section 53 in the SCI machine;Liquid storage tank 641 in the sheath fluid SCI machine
SCI sheath fluid divides two-way, is all the way preceding sheath fluid, from the RBC leading portion of test section 53, i.e., close to RBC test section 53
The position of test solution inlet into RBC test section 53 be all the way rear sheath fluid, it is described after sheath fluid also via sheath after one
Liquid pool 645 enters the back segment of RBC test section 53.
The buffer pool 642 connects RBC premixing pool 43, also connects the RBC via a sheath fluid waste liquid pool 644 and uses
The outlet of test section 53.
Wherein, when RBC test section 53 is in cleaning, the negative pressure of gas circuit unit to establish negative pressure in buffer pool 642;When need
When doing sample preparation, be connected to buffer pool 642 and RBC premixing pool 43, by the 5th test solution be drawn to RBC premixing pool 43 with
Pipeline between 53 specimen needle of RBC test section.During sample prepares, SCI sheath fluid respectively enters forebay and after-bay, is formed
Sheath stream, sheath fluid waste liquid pool 644 are connected to the liquid that atmosphere receives after-bay outflow.Sample syringe 431 is pushed away by the described 5th in pipeline
Test solution is pushed into the RBC test section 53 and measures RBC quantity, in measurement process, the remaining negative pressure of buffer pool 642, so that sheath fluid
A small amount of waste liquid of waste liquid pool 644 enters buffer pool 642, and buffer pool 642 is connected to atmosphere and is connected to sheath fluid waste liquid pool 644 later,
Waste liquid after receiving under the effect of gravity in sheath waste liquid pool 644, during this, the pressure of rear sheath waste liquid pool 644 substantially can with it is big
Air pressure is suitable, does not influence the stabilization of sample flow in RBC test section 53, then isolation buffer pond 642 and rear sheath waste liquid pool 644, then
It is connected to the negative pressure of buffer pool 642 and gas circuit unit, the waste liquid of rapid deflation buffer pool.It thus can be in measurement process by rear sheath
644 removal waste fluid of waste liquid pool and sample prepare parallel completion, shorten measurement period, improve measuring speed.In addition, buffer pool
642 negative pressure can prepare to provide power source for sample, therefore sample preparation does not need additional power source, is conducive to simplify knot
Structure.
In other embodiments, sample can not also be inhaled by the buffer pool 642, is changed to that a suction sample constant displacement pump is additionally arranged
Component (not shown) and the sample syringe 431 that pushes away cooperate the absorption RBC premixing pool 43 to the RBC test section 53.
In the present embodiment, liquid storage tank 641 is also connected with the diluent liquid storage tank 651 in the SCI machine, can pass through valve control
System charges the diluent in the diluent liquid storage tank 651 to liquid storage tank 641 in the SCI machine.
It should be noted that in the present embodiment, as described in Figure 12, the FCM sheath fluid of liquid storage tank 631 in the sheath fluid FCM machine,
Diluent in the SCI machine in the SCI sheath fluid of liquid storage tank 641 and the diluent liquid storage tank 651 both actually be from
The same reagent in same reagent bucket outside machine, therefore, in the present embodiment, the diluent liquid storage tank 651 and storage in the SCI machine
It is also connected with a diluent control valve 655 and one between liquid pool 641 and is loaded quantitative pump assembly 644, thus in control diluent control
When valve 655 is opened, the diluent liquid storage tank 651 can be used for supplying diluent, when control diluent control valve 655 is closed
When, the quantitative work of pump assembly 644 can be loaded to sample from liquid storage tank 641 in the SCI machine to described by the way that control is described
The liquid feeding pipeline of diluent liquid storage tank 651, to supply diluent instead of the diluent liquid storage tank 651.
In the present embodiment, as shown in Figures 2 and 3, liquid storage tank 641 is set on the right side plate 13 in the sheath fluid SCI machine;
The buffer pool 642 is set to the lower left of the foreboard 11.
It is appreciated that liquid storage tank can also be with the gas circuit unit 8 in liquid storage tank and diluent machine in the FCM sheath fluid machine
Connect, in the state of accessing the negative pressure of the gas circuit unit 8, reagent barrel draws reagent and stores the reagent from outside machine.
As shown in Fig. 2 and Figure 13, the reagent unit 6 further includes fluorescent reagent portion 66, and the fluorescent reagent portion 66 is used for
Fluorescent reagent is provided to the multiple WBC reaction tank 41;The fluorescent reagent portion 66 includes multiple fluorescent reagent receptacles
661, for each fluorescent reagent receptacle 661 for accommodating a kind of fluorescent reagent, each fluorescent reagent receptacle 661 is right
The WBC should be connected with the reaction tank 411 of the RET in reaction tank 41, NRBC premixing pool 412 and DIFF reaction tank
One in 413;Each fluorescent reagent receptacle 661 is glimmering with being provided with one between reaction tank 41 with the corresponding WBC
Light reagent quantitative pump assembly 662, for quantitatively controlling the fluorescent reagent for being delivered to each WBC reaction tank 41
As shown in Fig. 2, the fluorescent reagent receptacle 661 is set on the foreboard 11 and is located at the RBC test section
Front;The fluorescent reagent quantifies pump assembly 662 and is also set to the foreboard 11, and more the multiple WBC reaction tank in position
41 is low.
The waste unit 7 is used to collect and drain the waste liquid that the sample analyser 100 generates.
As shown in Fig. 3 and Figure 14, the waste unit 7 includes one first waste liquid pool 71, first waste liquid pool 71 and institute
Gas circuit unit 8 is stated to connect to access positive pressure and negative pressure;Wherein, when accessing negative pressure, first waste liquid pool 71 is used to collect waste liquid,
When accessing positive pressure, first waste liquid pool 71 is for draining waste liquid;The waste unit 7 further includes one second waste liquid pool 72, institute
It states the second waste liquid pool 72 and is used to replace the positive pressure and the negative pressure that access the gas circuit unit 8 with first waste liquid pool 71 alternately to receive
Collect and drain waste liquid;Wherein, when first waste liquid pool is negative pressure, second waste liquid pool 72 is positive pressure, first waste liquid
Pond 71 makes for collecting waste liquid, and second waste liquid pool 72 is for draining waste liquid;It is described when second waste liquid pool 72 is negative pressure
First waste liquid pool is positive pressure, and second waste liquid pool 72 is for collecting waste liquid, and first waste liquid pool 71 is for draining waste liquid;This
In embodiment, one second is respectively connected between first waste liquid pool 71 and second waste liquid pool 72 and the gas circuit unit 8
Control valve 76, second control valve 76 is preferably triple valve, for controlling first waste liquid pool 71 and second waste liquid
The negative pressure of the gas circuit unit 8, or the positive pressure or atmosphere of the access gas circuit unit 8 are accessed in pond 72.
The waste unit 7 further includes a third waste liquid pool 73, the third waste liquid pool 73 and first and second waste liquid pool
71,72 is different, do not access the positive pressure and negative pressure of the gas circuit unit 8, the third waste liquid pool 73 is by liquid sheet in pipeline
The power of body, such as the thrust of sheath fluid collect waste liquid;The third waste liquid pool 73 also connects with second waste liquid pool 72, leads to
Waste liquid in the third waste liquid pool 73 is drawn to second waste liquid pool 722 by the negative pressure crossed in second waste liquid pool 72, thus
Drain the waste liquid in the third waste liquid pool 73.It is appreciated that the third waste liquid pool 73 can also be with first waste liquid pool
71 connect to utilize the negative-pressure liquid discharge in first waste liquid pool 71.
In the present embodiment, as shown in figure 3, first waste liquid pool 71, second waste liquid pool 72 and the third waste liquid
Pond 73 is all set in 13 inside of right side plate, and first waste liquid pool 71 is set to the front of the FCM sheath liquid pool, with abundant
Utilize the space in the cabinet 1;Second control valve 76 is set to the top of corresponding waste liquid pool, so as to reduce pressure
The air consumption of gas circuit when switching.
The waste unit 7 further includes multiple waste solution channels 74, and the multiple waste solution channel 74 is connected to described take
Sample unit 2 divides between the liquid outlet and waste liquid pool above-mentioned of blood valve 3, reaction member 4 and the detection unit 5, and for leading
The waste liquid that the sample analyser 100 generates out;It is three groups, one group and first waste liquid pool that the multiple waste solution channel 74, which divides,
71 connect, and one group connects with second waste liquid pool 72, and one group connects with the third waste liquid pool 73.It is described in the present embodiment
First waste liquid pool 71 connects the waste liquid that the sampling unit 2 generates;Second waste liquid pool 72 connects HGB reaction tank 42 respectively
And waste liquid, institute caused by the HGB waste liquid, RBC premixing pool 43 and the RBC test section 53 that are generated with test section 52
State the cleaning waste liquid that WBC test section 51 generates and the waste liquid that the WBC reaction tank 41 generates;The third waste liquid pool 73
The detection waste liquid and the waste liquid for dividing blood valve 3 to generate that the WBC test section 51 generates are connect respectively, wherein the WBC inspection
The detection waste liquid in survey portion 51 can not need external pressure under the thrust of FCM sheath fluid and collect in the third waste liquid pool 73.Separately
Outside, first waste liquid pool 71 is also used to connect the waste liquid for dividing blood valve 3 and the WBC reaction tank 41 to generate.Described first
Waste liquid pool 71 is also connected to liquid storage tank in a few machine, in the state of accessing the negative pressure of the gas circuit unit 8, Xiang Suoshu to be at least
Liquid storage tank provides negative pressure in one machine, and liquid storage tank at least one described machine is made to draw reagent from outside machine.
As shown in figure 15, in the present embodiment, liquid storage tank 611 in the LD hemolytic agent machine, liquid storage tank in LN hemolytic agent machine
612, liquid storage tank 621 connects with first waste liquid pool 71 in liquid storage tank 613 and the DR dilution machine in LH hemolytic agent machine,
It is drawn in the state of accessing the negative pressure of the gas circuit unit 8, be used for the reagent barrel from outside machine in first waste liquid pool 71
Reagent;In the state of with the disconnection of the negative pressure of the gas circuit unit 8, liquid storage tank is closed liquid storage tank in above-mentioned machine, in above-mentioned machine
When supplying reagent, the consumption of reagent makes in the machine to form negative pressure in liquid storage tank liquid storage tank, so that liquid storage tank is also in above-mentioned machine
It can be used for automatically that reagent barrel draws reagent to supplement the reagent of consumption from outside machine.In other embodiments, it can also will be stored up in machine
Liquid pool access accesses the negative pressure of the gas circuit unit and carries out supply reagent with the imbibition from outside machine, and access positive pressure or atmosphere.It can be with
Understand, because second waste liquid pool 72 can also access negative pressure, therefore, in other embodiments, liquid storage in the LD hemolytic agent machine
Liquid storage tank 612 in pond 611, LN hemolytic agent machine, liquid storage tank 621 in liquid storage tank 613 and the DR dilution machine in LH hemolytic agent machine
It can also connect with second waste liquid pool 72.
Liquid storage tank 611 in the LD hemolytic agent machine, liquid storage tank 612 in LN hemolytic agent machine, liquid storage tank 613 in LH hemolytic agent machine
And the first control valve 75 is connected in the DR dilution machine between liquid storage tank 621 and the gas circuit unit 8, first control
Valve 75 is for controlling liquid storage tank 611 in the LD hemolytic agent machine, liquid storage tank 612 in LN hemolytic agent machine, liquid storage in LH hemolytic agent machine
The connection and truncation of gas circuit in pond 613 and the DR dilution machine between liquid storage tank 621 and the gas circuit unit 8;This implementation
In example, liquid storage tank 611 in the LD hemolytic agent machine, liquid storage tank 612 in LN hemolytic agent machine, in LH hemolytic agent machine liquid storage tank 613 and
Liquid storage tank 621 is separately connected first control valve 75 in the DR dilution machine, and each first control valve 75 divides
Liquid storage tank 611 in the LD hemolytic agent machine, liquid storage tank 612 in LN hemolytic agent machine, liquid storage tank in LH hemolytic agent machine are not controlled individually
613 and the DR dilution machine in gas circuit between liquid storage tank 621 and the gas circuit unit 8 connection and truncation;Wherein, may be used
So that liquid storage tank 613 and institute in liquid storage tank 611 in the LD hemolytic agent machine, liquid storage tank 612 in LN hemolytic agent machine, LH hemolytic agent machine
Stating liquid storage tank 621 in DR dilution machine, one first control valve 75 of connection, first control valve 75 are used for simultaneously jointly
Control liquid storage tank 611 in the LD hemolytic agent machine, liquid storage tank 612 in LN hemolytic agent machine, liquid storage tank 613 and institute in LH hemolytic agent machine
State the connection and truncation of the gas circuit in DR dilution machine between liquid storage tank 621 and the gas circuit unit 8.
When in a machine liquid storage tank 613 under the action of constant displacement pump 616, in hemolytic agent be shifted into reaction tank supply
When liquid, liquid storage tank and the outer reagent barrel of machine form the confined space of normal pressure in machine, that is, the pressure in the space is held essentially constant, machine
When interior liquid storage tank feed flow, of short duration negative pressure will form in liquid storage tank, the reagent of the outer reagent barrel of the negative pressure driving machine adds in machine
In buffer pool, until the liquid level of the reagent of the outer reagent barrel of machine drops to the confined space and can not be formed, when the examination of liquid storage tank in machine
When agent liquid level continues to drop to low level, constant displacement pump 616 can stop transferring reagent into reaction tank, and provide and believe without reagent failure
Breath.After reagent barrel is replaced outside machine, after user's point is eliminated without reagent failure, liquid storage tank in 71 connection machine of the first waste liquid pool is
Negative pressure is established in machine in liquid storage tank, so that the reagent of the outer reagent barrel of machine quickly charges in machine in liquid storage tank, due to liquid storage in machine
Pool volume is smaller, about 100 milliliters hereinafter, therefore can quickly complete and charge, after liquid storage tank charges full in machine, the first waste liquid pool
71 are not connected to liquid storage tank in machine, and liquid storage tank and the outer reagent barrel of machine form the confined space of normal pressure again in machine, and constant displacement pump moves again
Send the reagent of liquid storage tank in machine into reaction tank, the reagent with reagent barrel outside opportunity is inhaled into supplement the reagent of consumption.
First control valve 75 can be two-way valve or triple valve, when being triple valve, for controlling liquid storage in the machine
The negative pressure of the gas circuit unit 8, or the positive pressure or atmosphere of the access gas circuit unit, or truncation and the gas circuit unit are accessed in pond
Connection.In the present embodiment, first control valve 75 is set on the right side plate 13, to facilitate and the waste liquid pool and institute
State the connection in machine between liquid storage tank.
In this scheme, 76 normality of the second control valve accesses the negative pressure of the gas circuit unit 8.
In other embodiments, liquid storage tank 611 in the LD hemolytic agent machine, liquid storage tank 612, LH haemolysis in LN hemolytic agent machine
Liquid storage tank 621 can not also connect first waste liquid pool 71 in liquid storage tank 613 and the DR dilution machine in agent machine, and with it is described
The gas source of gas circuit unit 8 directly connects, and such as directly connects with negative pressure gas source, and the negative pressure gas source can be negative tank etc. of calming the anger.
In other embodiments, as shown in figure 16, it is not provided with first control valve 75, and in the LD hemolytic agent machine
Liquid storage tank 612 in liquid storage tank 611, LN hemolytic agent machine, liquid storage tank in liquid storage tank 613 and the DR dilution machine in LH hemolytic agent machine
Third control valve 77 is connected between 621 and the outer reagent source of machine such as corresponding hemolytic agent bucket, wherein in this scheme, described second
76 normality of control valve accesses the positive pressure or atmosphere of the gas circuit unit 8, makes liquid storage tank reaction tank feed flow in machine.Implement at one
In example, second control valve 76 accesses atmosphere, and third control valve 77 disconnects the connection of liquid storage tank in the outer reagent barrel of machine and machine, fixed
It measures and pumps the reagent for switching liquid storage tank in drag-over unit for passing through positive/negative-pressure to reaction tank;In another embodiment, second control
Valve 76 processed accesses positive pressure, the connection of liquid storage tank in the outer reagent barrel of the disconnection machine of third control valve 77 and machine, in the positive pressure driving machine
The reagent of liquid storage tank enters constant displacement pump, and then constant displacement pump delivers reagents into reaction tank under positive pressure driving.With the implementation of front
Example is identical, when the second control valve 76 accesses negative pressure, and third control valve 77 connect the outer reagent barrel of machine with liquid storage tank in machine, outside machine
The reagent of reagent barrel is charged into machine in liquid storage tank.This scheme is compared with the scheme of Figure 15, because this programme utilizes described first
Positive pressure in waste liquid pool 71 or atmospheric pressure carry out feed flow, thus, when feed flow, cannot form negative pressure in machine in liquid storage tank, thus
Also it cannot be added in machine in buffer pool using the reagent of the outer reagent barrel of the automatic driving machine of this negative pressure;In addition, when in a certain machine
Liquid storage tank need to stop to charge and feed flow and when carrying out emptying maintenance, this programme from reagent barrel without proposing bottle cap component
Come, directly closes the third control valve 77.
As shown in Fig. 4,5 and 17, the gas circuit unit 8 includes positive pressure gas circuit 81 and negative pressure gas circuit 82, respectively to described
Sample analyser 100 provides positive pressure and negative pressure, the positive pressure gas circuit 81 and negative pressure gas circuit 82 connect with gas source 80 outside machine.
The positive pressure gas circuit 81 includes filter 811, drying machine 812, air accumulator 813, pressure regulator valve 814, pressure detecting member
Part 815 and executive component 816.The filter 811, drying machine 812,813 phase of air accumulator concatenation, the filter 811 and machine
Outer big tank gas source connects.The filter 811, drying machine 812 are set in the back plate 12, and the air accumulator 813 is set to described
In the space that left plate 14 and the middle partition 15 are formed, and it is fixedly arranged on the lower surface of the upper spacer 16.Wherein, described
The air accumulator 813 is set inside sample analyser 100, the stable pressure of the sample analyser 100 can be supplied to, is buffered
Pressure oscillation.
In the present embodiment, the positive pressure gas circuit 81 connects the sampling unit 2, divides blood valve 3, reaction member 4, detection unit
5, reagent unit 6 and waste unit 7, for transporting swab component 222 for example, operate the sampling needle driving assembly 212
Make, make the running of point blood valve 3, make it is each the running such as be loaded quantitative pump assembly, charge quantitative pump assembly, syringe, operate waste liquid pool
Carry out drain etc..
The negative pressure gas circuit 82 includes overflow valve 821 and reverse-filling pond 822, the overflow valve 821 and reverse-filling in parallel
Pond 822 is connected separately with pressure sensing element 815 and executive component 816.The overflow valve 821, the pressure sensing element 823
And the reverse-filling pond 822 is set to the outside of the left plate 14, to manipulate and to observe;Also, the overflow valve 821 is used for
The size of negative pressure is adjusted, the reverse-filling pond 822 is for the liquid that receiving is flowed backward when flowing backward to prevent the liquid flowed backward
Influence the performance of the pressure sensing element 823 in turn into the negative pressure gas circuit 82.
The negative pressure gas circuit 82 connects respectively being loaded, charging quantitative pump assembly and the first, second waste liquid for the reagent unit 6
Pond 71,72 etc., for for example, make it is each sample-adding, charge constant displacement pump component operational, make waste liquid pool running carry out waste collection, make machine
Interior liquid storage tank draws reagent etc. from outside machine.
The control assembly 9 is used for: being controlled the sampling unit 2 and is acquired blood sample;Divide blood valve 3 that will acquire described in control
The blood sample arrived carries out Quantitative Separation;It controls the running of gas circuit unit 8 and distributes the blood sample after Quantitative Separation to institute simultaneously
Each reaction tank is stated, and controls and distributes the reagent that reagent unit 6 provides to each reaction tank;Each reaction tank is made to by control
To test solution be injected into the detection unit 5, and control and will test required reagent and distribute to the detection unit 5;Control institute
Detection unit 5 is stated to detect the test solution and form detection information.
The control assembly 9 is also used to: control first waste liquid pool 71 is negative pressure, is used for first waste liquid pool 71
Waste liquid is collected, meanwhile, controlling second waste liquid pool 72 is positive pressure, makes second waste liquid pool 72 for draining waste liquid;Or control
Making second waste liquid pool 72 is negative pressure, makes second waste liquid pool 72 for collecting waste liquid, meanwhile, control first waste liquid
Pond 71 is positive pressure, makes first waste liquid pool 71 for draining waste liquid.
The control assembly 9 is also used to: controlling the negative pressure that liquid storage tank at least one machine is directly accessed the gas circuit unit 8
Gas source makes liquid storage tank at least one described machine draw reagent from outside machine;And control liquid storage tank and institute at least one described machine
The negative pressure gas source for stating gas circuit unit 8 disconnects, and makes the closed liquid storage tank of liquid storage tank at least one described machine, and control is described at least
Liquid storage tank supplies reagent to the reaction member 4 in one machine, makes to form negative pressure in liquid storage tank at least one described machine, in turn
Liquid storage tank at least one described machine is set to draw reagent from outside machine automatically to supplement the reagent of consumption.
The control assembly 9 is also used to: control first waste liquid pool 71 accesses the negative pressure of the gas circuit unit 8, control
Liquid storage tank connects first waste liquid pool 71 at least one described machine, draws liquid storage tank at least one described machine from outside machine
Reagent;And control liquid storage tank and the first waste liquid pool 71 at least one described machine and disconnect, make the closed storage of liquid storage tank in the machine
Liquid pool, and liquid storage tank makes to store up at least one described machine to the reaction member 4 supply reagent at least one described machine of control
Negative pressure is formed in liquid pool, and then liquid storage tank at least one described machine is made to draw reagent from outside machine automatically to supplement the examination of consumption
Agent.
The control assembly 9 is also used to: control the negative pressure that the buffer pool connects the gas circuit unit 8, later, disconnect with
The connection of second waste liquid pool utilizes the 5th test solution in RBC premixing pool described in the negative pressure absorbing in the buffer pool, control
The SCI sheath fluid is divided two-way to be pushed into the RBC test section by system, and is made using the remaining negative pressure in the buffer pool described
Waste liquid in sheath fluid waste liquid pool enters the buffer pool 642, controls the buffer pool 642 and is communicated with the atmosphere and is connected to the sheath fluid
Waste liquid in the sheath fluid waste liquid pool is drained into the buffer pool using gravity, controlled the buffer pool 642 and institute by waste liquid pool
The connection stated between sheath fluid waste liquid pool disconnects, and controls the buffer pool and is connected to the negative pressure of gas circuit unit, the buffering is discharged
Waste liquid in pond.
As shown in figure 4, the control assembly 9 includes a circuit board assemblies 91, the circuit board assemblies 91 are set to described
The top of upper spacer 16 prevents the circuit board assemblies 91 contaminated to be isolated with each gas circuit, liquid correlation unit.
Figure 18 is please referred to, the technical program second embodiment provides a kind of sample analyser using first embodiment
100 carry out the method for sample analysis 200 of sample analysis, comprising steps of
S201 acquires blood sample by a sampling unit;
Collected blood sample is carried out Quantitative Separation by one point of blood valve by S202;
S203 by a gas circuit unit and described divides blood valve by the blood sample after Quantitative Separation while distribution is to multiple anti-
Ying Chi, and the reagent that a reagent unit provides is distributed to the multiple reaction tank;
The prepared test solution of the multiple reaction tank is injected into corresponding test section by S204, and by a reagent unit
Reagent needed for the detection of offer is distributed to each test section;
S205 detects the test solution by each test section and forms detection information.
One first waste liquid pool, is accessed the negative pressure of the gas circuit unit by S206, and the waste liquid after will test drains into described
One waste liquid pool;And first waste liquid pool is accessed to the positive pressure of the gas circuit unit, the waste liquid in first waste liquid pool is arranged
It walks.
It further comprises the steps of:
When first waste liquid pool is negative pressure, one second waste liquid pool of setting is positive pressure, is used for second waste liquid pool
Drain waste liquid;When first waste liquid pool is positive pressure, it is negative pressure that second waste liquid pool, which is arranged, uses second waste liquid pool
In collection waste liquid.
It further comprises the steps of:
When first waste liquid pool accesses negative pressure, make at least one machine of the reagent unit liquid storage tank and described the
The connection of one waste liquid pool makes liquid storage tank at least one described machine that negative pressure be utilized to draw reagent from the outside;
Liquid storage tank at least one described machine and first waste liquid pool are disconnected, liquid storage tank at least one described machine is made
For closed liquid storage tank, and reagent is supplied to the reaction member by liquid storage tank at least one described machine, makes described at least one
Negative pressure is formed in a machine in liquid storage tank, and then so that liquid storage tank is drawn reagent from outside machine automatically and is disappeared with supplementing
The reagent of consumption.
Aforementioned two step can be with are as follows:
Liquid storage tank at least one machine of the reagent unit is directly connected with the negative pressure gas source of the gas circuit unit, is made
Liquid storage tank draws reagent using negative pressure from the outside at least one described machine.
The negative pressure gas source of liquid storage tank at least one described machine and the gas circuit unit is disconnected, at least one described machine is made
Interior liquid storage tank is closed liquid storage tank, and liquid storage tank makes institute to reaction member supply reagent at least one described machine of control
It states and forms negative pressure at least one machine in liquid storage tank, and then liquid storage tank at least one described machine is made to draw reagent from outside machine automatically
To supplement the reagent of consumption.
Compared to traditional sample analyser, the technical program embodiment sample analyser is had the advantages that
1. using dividing blood valve to distribute by blood sample Quantitative Separation and simultaneously, to keep measurement result more accurate and measure
Fast speed;And the position setting of each unit is rationally, such as the multiple reaction tank is all connected with and described divide blood valve and is located at institute
A point top for blood valve is stated, etc. to have lesser energy consumption, less sample losses and detect speed faster;
2. generally, cloth gas path component between left plate and middle partition, between right side plate and middle partition and foreboard cloth liquid
Body associated components, upper spacer cloth control unit prevent mutual adverse effect to accomplish separating dry space from moist space;
3. air accumulator in positive pressure gas circuit setting machine can provide biggish power so as to drive faster detection speed
Degree;Reverse-filling pond is arranged in negative pressure gas circuit, can flow backward to avoid liquid to negative pressure gas circuit;
4. liquid storage tank in setting machine, so as in machine, conveniently make the temporary part of the reagent of reagent barrel outside machine
With;
5. liquid storage tank in machine is connected with the negative pressure of gas circuit unit, so as to so that in machine liquid storage tank under the action of negative pressure from
Reagent is drawn outside machine, does not need manually to charge, it is time saving and energy saving;Especially, liquid storage tank in machine is connected with the first waste liquid pool, not only
The negative pressure that can use the first waste liquid pool draws reagent from outside machine, moreover it is possible to which when flowing backward, reagent is flowed backward in receiving, to prevent
Reagent, which flows backward, enters gas circuit;Also, when disconnecting the negative pressure of liquid storage tank in machine and gas circuit unit, liquid storage tank forms closed storage in machine
Liquid pool can form negative pressure in liquid storage tank in machine when supplying reagent, so as to draw examination from outside machine automatically while feed flow
Agent;
6. the first waste liquid pool is in parallel with the second waste liquid pool, it alternately accesses positive and negative pressure and is drained with alternating, collects waste liquid, from
And the unbroken collection waste liquid of entire instrument can be made, the efficiency for collecting waste liquid is higher, and then can also promote entire instrument
Detect speed.
The above is the preferred embodiment of the present invention, it is noted that those skilled in the art are come
It says, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also considered as this
The protection scope of invention.
Claims (31)
1. a kind of sample analyser, comprising:
Sampling unit, for acquiring blood sample;
Divide blood valve, the adjacent sampling unit, the blood sample for acquiring sampling unit carries out Quantitative Separation and same time-division
Match;
Reaction member, for making the blood sample for dividing blood valve to distribute form test solution, the reaction member includes multiple reactions
Pond, the multiple reaction tank are all connected with the top for dividing blood valve and divide blood valve described in;
Detection unit, the adjacent reaction member, including multiple test sections, for detect the test solution that the reaction member generates with
Form detection information;
Reagent unit, reagent needed for being used to provide the described each unit of sample analyser;
Gas circuit unit, for driving the blood sample, test solution and reagent to transfer between each unit of the sample analyser;And
Control assembly is used for: controlling the sampling unit acquisition blood sample;Divide blood valve by collected blood sample described in control
This progress Quantitative Separation;It controls gas circuit cell operation and distributes the blood sample after Quantitative Separation to each reaction tank simultaneously,
And it controls the reagent that reagent unit is provided and distributes to each reaction tank;Each prepared test solution of reaction tank is injected in control
The extremely detection unit, and control will test required reagent and distribute to the detection unit;Control the detection unit detection
The test solution simultaneously forms detection information.
2. sample analyser as described in claim 1, which is characterized in that the sample analyser further includes a waste unit,
The waste unit includes one first waste liquid pool and one second waste liquid pool, and first waste liquid pool and second waste liquid pool are distinguished
Connect with the gas circuit unit, second waste liquid pool can replace access gas circuit unit just with first waste liquid pool respectively
Pressure and negative pressure are to collect and drain waste liquid.
3. sample analyser as claimed in claim 2, which is characterized in that the control assembly is also used to: control described first
Waste liquid pool is negative pressure, makes first waste liquid pool for collecting waste liquid, meanwhile, controlling second waste liquid pool is positive pressure, makes institute
The second waste liquid pool is stated for draining waste liquid;Or control second waste liquid pool is negative pressure, makes second waste liquid pool for collecting
Waste liquid, meanwhile, controlling first waste liquid pool is positive pressure, makes first waste liquid pool for draining waste liquid.
4. sample analyser as claimed in claim 2, which is characterized in that the waste unit further includes multiple waste solution channels,
The multiple waste solution channel is separately connected the reaction member and the detection unit, and for exporting the reaction member and institute
State the waste liquid of detection unit generation;The multiple waste solution channel is divided into two groups, and one group connects with first waste liquid pool, one group with
Second waste liquid pool connects.
5. such as the described in any item sample analysers of Claims 1-4, which is characterized in that the reagent unit includes at least one
Liquid storage tank in a machine, liquid storage tank connects with the gas circuit unit at least one described machine, is accessing the negative of the gas circuit unit
In the state of pressure, liquid storage tank is used to draw reagent from outside machine and stores the reagent at least one described machine;Described at least one
Liquid storage tank is also used to supply reagent to the reaction member in a machine.
6. sample analyser as claimed in claim 5, which is characterized in that in the state with the disconnection of the negative pressure of the gas circuit unit
Under, liquid storage tank is closed liquid storage tank at least one described machine, and liquid storage tank is to the reaction member at least one described machine
When supplying reagent, the consumption of reagent makes to form negative pressure at least one described machine in liquid storage tank, the negative pressure make it is described at least
Liquid storage tank draws reagent from outside machine to supplement the reagent of consumption in one machine.
7. sample analyser as claimed in claim 5, which is characterized in that the control assembly is also used to: control is described at least
The negative pressure gas source of liquid storage tank and the gas circuit unit disconnects in one machine, makes the closed liquid storage of liquid storage tank at least one described machine
Pond, and liquid storage tank makes liquid storage at least one described machine to reaction member supply reagent at least one described machine of control
Negative pressure is formed in pond, the negative pressure makes liquid storage tank at least one described machine draw reagent from outside machine automatically to supplement consumption
Reagent.
8. such as the described in any item sample analysers of claim 5 to 7, which is characterized in that liquid storage tank at least one described machine
The first control valve is connected between the gas circuit unit, first control valve is for controlling liquid storage at least one described machine
The connection and truncation of gas circuit between pond and the gas circuit unit.
9. such as the described in any item sample analysers of claim 5 to 7, which is characterized in that storage at least one each described machine
The first control valve is respectively connected between liquid pool and the gas circuit unit, first control valve is corresponding described for independent control
The connection and truncation of gas circuit in machine between liquid storage tank and the gas circuit unit.
10. such as the described in any item sample analysers of claim 8 to 9, which is characterized in that first control valve is threeway
Valve accesses the negative pressure of the gas circuit unit for controlling liquid storage tank at least one described machine, or accesses the gas circuit unit
Positive pressure or atmosphere.
11. such as the described in any item sample analysers of claim 5 to 10, which is characterized in that liquid storage at least one described machine
Pond directly connects with the gas source of the gas circuit unit, and liquid storage tank can when the gas source is negative pressurized air source at least one described machine
For drawing reagent from outside machine.
12. such as the described in any item sample analysers of claim 5 to 10, which is characterized in that the sample analyser further includes
One waste unit, the waste unit include one first waste liquid pool, and first waste liquid pool connects with the gas circuit unit;It is described
First waste liquid pool can be used for collecting the waste liquid that the sample analyser generates when accessing the negative pressure of the gas circuit unit, access
It can be used for draining the waste liquid that the sample analyser generates when the positive pressure of the gas circuit unit or accessible atmosphere;Described at least one
Liquid storage tank connects to connect with the gas circuit unit with first waste liquid pool in a machine, liquid storage tank at least one described machine
It can be used for drawing reagent from outside machine in the state that first waste liquid pool accesses negative pressure.
13. sample analyser as claimed in claim 12, which is characterized in that the control assembly is also used to: control is described extremely
Liquid storage tank and the first waste liquid pool disconnect in a few machine, make the closed liquid storage tank of liquid storage tank in the machine, and control is described at least
Liquid storage tank supplies reagent to the reaction member in one machine, makes to form negative pressure in liquid storage tank at least one described machine, described
Negative pressure makes liquid storage tank at least one described machine draw reagent from outside machine automatically to supplement the reagent of consumption.
14. sample analyser as claimed in claim 12, which is characterized in that first waste liquid pool and the gas circuit unit it
Between be connected with one second control valve, second control valve is accessing the gas circuit unit just for controlling first waste liquid pool
Pressure or atmosphere, or the negative pressure of the access gas circuit unit.
15. such as the described in any item sample analysers of claim 5 to 14, which is characterized in that liquid storage at least one described machine
Pond includes liquid storage tank in hemolytic agent machine, for supplying hemolytic agent to reaction member;And/or including liquid storage tank in a dilution machine,
For supplying reticulocyte determination dilution to reaction member.
16. such as the described in any item sample analysers of claim 1 to 17, which is characterized in that the gas circuit unit includes positive pressure
Gas circuit, the positive pressure gas circuit include air accumulator in a machine, and air accumulator is for connecting a gas source and dividing to the sample in the machine
Analyzer provides positive pressure.
17. sample analyser as described in claim 1, which is characterized in that before the sample analyser is including a bottom plate, one
Plate, an opposite back plate parallel with the foreboard, an openable and closable right side plate for being connected to the back plate, one retractable are connected to
The left plate of the back plate, one are set to middle partition between the right side plate and the left plate and vertical connect in described
The upper spacer of partition.
18. the sample analyser as described in benefit requires 17, which is characterized in that each reaction tank is respectively connected with sample-adding constant displacement pump
Component, each quantitatively pump assembly that is loaded are loaded for quantitative into corresponding reaction tank, all quantitative pump groups of sample-adding
The position of part is below the position for dividing blood valve.
19. sample analyser as claimed in claim 17, which is characterized in that the sample analyser further includes a waste liquid list
Member, the waste liquid generated for collecting and draining the sample analyser, the waste unit include one first waste liquid pool, and described the
One waste liquid pool connects with the gas circuit unit to access positive pressure and negative pressure;Wherein, when negative pressure, first waste liquid pool is for collecting
Waste liquid, when positive pressure, first waste liquid pool is for draining waste liquid;And
The reagent unit includes liquid storage tank in machine, in the machine liquid storage tank for from the outside draw reagent, storage reagent and to
The multiple reaction tank supplies reagent;Liquid storage tank connects with first waste liquid pool in the machine, connects in first waste liquid pool
When entering the negative pressure of the gas circuit unit, liquid storage tank is for drawing hemolytic agent from outside machine in the machine, and liquid storage tank is also used in the machine
In when cutting off the connection with the negative pressure of the gas circuit unit, and supplying hemolytic agent to the reaction tank, drawn automatically from outside machine
Hemolytic agent.
20. the sample analyser as described in benefit requires 19, which is characterized in that liquid storage tank includes in three hemolytic agent machines in the machine
Liquid storage tank, liquid storage tank is liquid storage tank in leukocyte analysis hemolytic agent machine, erythroblast analysis with molten in the hemolytic agent machine
Liquid storage tank in liquid storage tank and hemoglobin analysis hemolytic agent machine in blood agent machine;
The multiple reaction tank includes optical analysis reaction tank, hemoglobin analysis reaction tank and red blood cell determination premix
Pond;The optical analysis reaction tank is three reaction tanks, respectively reticulocyte determination reaction tank, erythroblast point
Analysis premixing pool and leukocyte analysis reaction tank;
Wherein, liquid storage tank connects the leukocyte analysis reaction tank and is used for institute in leukocyte analysis hemolytic agent machine
It states leukocyte analysis reaction tank and leukocyte analysis hemolytic agent, liquid storage in the erythroblast analysis hemolytic agent machine is provided
Pond connects the erythroblast analysis premixing pool and is used to be provided with core with premixing pool to the erythroblast analysis red
Cell analysis hemolytic agent, liquid storage tank connects the hemoglobin analysis and reacts in hemoglobin analysis hemolytic agent machine
Pond simultaneously is used to provide hemoglobin analysis hemolytic agent with reaction tank to the hemoglobin analysis;The leukocyte analysis is with molten
Liquid storage tank in blood agent machine, liquid storage in liquid storage tank and hemoglobin analysis hemolytic agent machine in erythroblast analysis hemolytic agent machine
Pond is set on the upper spacer, and adjacent optical analysis is arranged with test section.
21. the sample analyser as described in benefit requires 20, which is characterized in that described to divide in blood valve including erythroblast analysis use
Channel, leukocyte analysis channel are distributed to corresponding reaction tank via the channel respectively after blood sample Quantitative Separation;
Liquid storage tank connects the leukocyte analysis channel and then connects the leucocyte point in the leukocyte analysis hemolytic agent machine
Analysis reaction tank, in the erythroblast analysis hemolytic agent machine liquid storage tank connect erythroblast analysis channel into
And connect the erythroblast analysis premixing pool.
22. the sample analyser as described in benefit requires 20, which is characterized in that in the machine liquid storage tank further include a net knit it is red thin
Born of the same parents measure with liquid storage tank in dilution machine, in the reticulocyte determination dilution machine liquid storage tank connect the net knit it is red thin
Born of the same parents measure with reaction tank, and liquid storage tank is surveyed for drawing granulophilocyte from the outside in reticulocyte determination dilution machine
Determine to be knitted with dilution, storage reticulocyte determination dilution and to the reticulocyte determination with reaction tank supply network red
Raji cell assay Raji dilution;Further include reticulocyte determination channel in described point of blood valve, is passed through after blood sample Quantitative Separation
It is distributed by the channel to corresponding reaction tank;Liquid storage tank connects the net and knits in reticulocyte determination dilution machine
Red blood cell determination channel is to connect the reticulocyte determination reaction tank;The reticulocyte determination dilution
Liquid storage tank is set on the upper spacer in machine, and the neighbouring optical analysis is arranged with test section.
23. such as the described in any item sample analysers of claim 19 to 22, which is characterized in that the waste unit further includes one
Second waste liquid pool, the waste liquid generated for collecting and draining the sample analyser, second waste liquid pool are useless with described first
The positive pressure and negative pressure that liquid pool can replace respectively access gas circuit unit are to collect and drain waste liquid;First waste liquid pool and described
Second waste liquid pool is all set in the right side plate towards on the face of the middle partition.
24. such as the described in any item sample analysers of claim 17 to 23, which is characterized in that the gas circuit unit includes positive pressure
Gas circuit, the positive pressure gas circuit include air accumulator in a machine, and air accumulator is installed on the lower section of upper spacer in the machine, is located at middle partition
Between left plate.
25. a kind of method of sample analysis, comprising steps of
Sample analyser is provided, there is sampling unit, divide blood valve, multiple reaction tanks, multiple test sections, reagent unit and gas circuit list
Member;
Blood sample is acquired by sampling unit;
By dividing blood valve that collected blood sample is carried out Quantitative Separation;
By gas circuit unit and it is described divide blood valve to make Quantitative Separation after blood sample and meanwhile distribution to multiple reaction tanks, and make institute
The reagent for stating reagent unit offer is distributed to the multiple reaction tank;
The prepared test solution of the multiple reaction tank is injected into corresponding test section, and the inspection that the reagent unit is provided
Reagent needed for surveying is distributed to each test section;
The test solution is detected by each test section and forms detection information.
26. method of sample analysis as claimed in claim 25, which is characterized in that further comprise the steps of: and connect one first waste liquid pool
Enter the negative pressure of the gas circuit unit, the waste liquid after will test drains into first waste liquid pool;And first waste liquid pool is connect
The positive pressure for entering the gas circuit unit drains the waste liquid in first waste liquid pool.
27. method of sample analysis as claimed in claim 26, which is characterized in that further comprise the steps of: in first waste liquid pool
Access negative pressure when, liquid storage tank at least one machine of the reagent unit is connected to first waste liquid pool, make described at least
Liquid storage tank draws reagent using negative pressure from the outside in one machine.
28. method of sample analysis as claimed in claim 27, which is characterized in that further comprise the steps of: at least one described machine
Interior liquid storage tank and first waste liquid pool disconnect, and make the closed liquid storage tank of liquid storage tank at least one described machine, when it is described at least
When reagent in one machine in liquid storage tank is supplied to the reaction member, negative pressure is formed at least one described machine in liquid storage tank,
The negative pressure makes liquid storage tank at least one described machine draw reagent from outside machine automatically to supplement the reagent of consumption.
29. method of sample analysis as claimed in claim 25, which is characterized in that comprising steps of extremely by the reagent unit
Liquid storage tank directly connects with the negative pressure gas source of the gas circuit unit in a few machine, utilizes liquid storage tank at least one described machine
Negative pressure draws reagent from the outside.
30. method of sample analysis as claimed in claim 29, which is characterized in that further comprise the steps of: at least one described machine
The negative pressure gas source of interior liquid storage tank and the gas circuit unit disconnects, and makes the closed liquid storage tank of liquid storage tank at least one described machine, and
It controls at least one described machine liquid storage tank and supplies reagent to the reaction member, make at least one described machine shape in liquid storage tank
At negative pressure, the negative pressure makes liquid storage tank at least one described machine draw reagent from outside machine automatically to supplement the reagent of consumption.
31. method of sample analysis as claimed in claim 26, which is characterized in that further comprise the steps of: in first waste liquid pool
When for negative pressure, one second waste liquid pool of setting is positive pressure, makes second waste liquid pool for draining waste liquid;In first waste liquid pool
When for positive pressure, it is negative pressure that second waste liquid pool, which is arranged, makes second waste liquid pool for collecting waste liquid.
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CN113495167A (en) * | 2021-06-24 | 2021-10-12 | 迈克医疗电子有限公司 | Reagent loading method and device for blood cell analyzer |
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