KR101807746B1 - Multi dispenser for automated hematology analyzer - Google Patents

Multi dispenser for automated hematology analyzer Download PDF

Info

Publication number
KR101807746B1
KR101807746B1 KR1020160012750A KR20160012750A KR101807746B1 KR 101807746 B1 KR101807746 B1 KR 101807746B1 KR 1020160012750 A KR1020160012750 A KR 1020160012750A KR 20160012750 A KR20160012750 A KR 20160012750A KR 101807746 B1 KR101807746 B1 KR 101807746B1
Authority
KR
South Korea
Prior art keywords
blood
reagent
unit
dispenser
metering valve
Prior art date
Application number
KR1020160012750A
Other languages
Korean (ko)
Other versions
KR20170091898A (en
Inventor
전태호
이규만
Original Assignee
(주)뉴옵틱스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by (주)뉴옵틱스 filed Critical (주)뉴옵틱스
Priority to KR1020160012750A priority Critical patent/KR101807746B1/en
Publication of KR20170091898A publication Critical patent/KR20170091898A/en
Application granted granted Critical
Publication of KR101807746B1 publication Critical patent/KR101807746B1/en

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1004—Cleaning sample transfer devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • G01N2035/102—Preventing or detecting loss of fluid by dripping
    • G01N2035/1023—Preventing or detecting loss of fluid by dripping using a valve in the tip or nozzle

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A blood storage container for storing blood for use in hematology analyzers and a reagent storage container for storing reagents for blood tests, and a multi-dispenser for automatic blood cell analysis for discharging a large number of blood and reagents, respectively, Axis moving unit provided on the support, a Z-axis moving unit provided on the X-axis moving unit, and a plurality of sample storage containers mounted on the Z-axis moving unit and capable of moving up and down and containing blood or blood and reagents And a control module for controlling the dispenser unit to regulate the amount of blood or reagent discharged into the plurality of sample storage vessels according to a dispenser unit to be discharged, a kind of reagent, or an input amount of reagent, A configuration in which a module is mounted can be provided, and a large number of diagnostic specimens can be generated at a high speed .

Description

[0001] Description [0002] Multi-dispenser for automated hematology analyzer [

The present invention relates to a multi-dispenser for automatic blood cell analysis, and more particularly, to a multi-dispenser for automatic blood cell analysis, which comprises a blood storage container for storing blood and a reagent storage container for storing a reagent for blood testing, To a multi-dispenser for automatic hematology analysis.

In general, the concentration of electrolytes, gaseous species and metabolites in the blood, or the hematocrit ratio maintains the homeostasis in the human body, and when concentration imbalance occurs, it causes various diseases with excessive or deficiency of the concentration. Thus, rapid measurement of blood electrolytes, gaseous species and metabolites, or hematocrit, helps clinicians to quickly predict the dysfunction and disease progression of the body from bioequivalence.

One of the methods for examining such blood is the Complete Blood Cell Count (CBC) test widely used. These CBC tests are one of the most basic blood tests with various clinical indications ranging from diagnosis, treatment and follow-up of the disease. Through this test, information on three types of cells (blood cells) present in the blood, that is, red blood cells, white blood cells and platelets, can be obtained by using various parameters.

Analysis of blood samples is generally based on the total number of leukocytes, specifically leukocytes by sub-population (basophils, eosinophils, neutrophils, monocytes, and lymphocytes) The number of red blood cells and platelets, and the level of hemoglobin.

For example, an assay for hemoglobin is performed after dissolution of red blood cells, that is, after membrane breakage of red blood cells, and by spectrophotometric determination of hemoglobin separated from the medium, and also by measuring the absorption ability of a single compound at an appropriate wavelength Stabilization of the complex form of hemoglobin (oxyhemoglobin or cyanomethemoglobin) is required for measurement. The total leukocyte count for the blood sample is made by resistivity, which combines the specific dissolution of red blood cells and the protection of leukocytes.

In order to obtain numerical information of blood cells, an automatic hematology analyzer which automatically measures the number of blood cells in a certain volume after appropriately diluting blood is widely used. Numerical data of hemocyte can be obtained by the technique of measuring the number of cells through a microscope using a hemocytometer, but an automated hematology analyzer is more widely used because it can measure various indices other than numerical information .

1, the automatic hematology analyzer includes a dispenser unit 10 for sucking blood and discharging a predetermined amount, and a reagent chamber 20 for holding a plurality of reagent tubes 21 storing a plurality of reagents The dispenser unit 10 includes a support 11, an X-axis moving unit 12 provided on the support 11, a Z-axis moving unit 13 provided on the X-axis moving unit 12, A quantitative dispenser 14 mounted on the mobile unit 13 and movable up and down and having a suction and discharge function, and a needle 15 for sucking blood and discharging the blood to a plurality of reagent tubes in a blood tube storing blood do.

In the dispenser unit 10, the dosing dispenser 14 is lowered by the Z-axis moving unit 13 so as to draw a certain amount of blood from the blood tube and ascend, And a predetermined amount of blood is discharged to the plurality of reagent tubes 21 by repeating the descending and ascending operations.

Examples of techniques related to this are disclosed in Documents 1 and 2 below.

For example, the following Patent Document 1 discloses an oil pump comprising an inlet portion through which oil flows from a pump and a plurality of discharge portions through which the oil is discharged, and a plurality of cylinders communicating with the plurality of discharge portions by a communication line are formed therein A plurality of pistons for selectively opening and closing the communication lines while reciprocating in the plurality of cylinders based on the inflow and outflow of the oil, a plurality of pistons for selectively opening and closing the communication lines, A plurality of springs which are provided between the plurality of pistons and the plurality of plugs and elastically bias the pistons in a direction in which the pistons shield the communication lines, one end of which is coupled to the pistons and the other end of which is connected to the body And is reciprocated together with the piston, There is disclosed for the quantitative valve including a plurality of indicators indicating the reciprocating process to the outside.

Patent Document 2 discloses a strap in which a plurality of receiving holes for accommodating a blood sample of a patient are formed, a diluting liquid dispensing period in which a diluting liquid is injected into a receiving hole of the strap, and a strap is seated, A shaking part for moving the blood to be mixed therewith, a shaking part coupled to one end of the shaking part, for sucking diluted blood located in each of the receiving holes, a suction part for sucking blood through the nozzle, And a water introducing portion for adding water to the blood sucked through the suction portion; a lifting portion which is provided at a lower portion of the wasching portion and is disposed at one end of the shaking portion, for transporting the strap wadded by the washing portion downward; And an enzymatic reagent solution is introduced into the receiving hole of the strap which is lowered by the elevating portion to be dispensed, It is disclosed for a blood test apparatus that has a cycle.

Korean Registered Patent No. 10-1033219 (registered on April 28, 2011) Korean Registered Patent No. 10-1524672 (Registered May 5, 2015)

However, in the conventional technique as described above, it is necessary to precisely control the X-axis moving unit in order to discharge blood to a plurality of reagent tubes. In the case of applying dozens of reagent tubes, it is troublesome for the user to replace the reagent chamber .

In addition, the repeated use of the X-axis moving unit accumulates the fatigue of the equipment, making it difficult to accurately discharge the reagent to the reagent tube, and there is a case where the reagent comes into contact with the needle.

SUMMARY OF THE INVENTION An object of the present invention is to provide a multi-dispenser for automatic hematology analysis which can generate a large number of diagnostic specimens at a high speed.

Another object of the present invention is to provide a multi-dispenser for automatic hematology analysis that can realize the quality management of automatic hematology analysis.

It is another object of the present invention to provide a multi-dispenser for automatic hematology analysis that reduces fatigue of an automatic hematology analyzer.

In order to achieve the above object, an automatic blood group analyzer multi-dispenser according to the present invention includes: an X-axis moving unit provided on a support; a Z-axis moving unit provided in the X-axis moving unit; A dispenser unit for discharging blood or blood and a reagent to a plurality of sample storage containers, a dispenser unit for controlling the dispenser unit to regulate the amount of blood or reagent discharged into the plurality of sample storage containers according to a kind of reagent or an input amount of reagent And a control module, wherein the dispenser unit is equipped with a plurality of discharge modules.

In the multi-dispenser for automatic hemocyte analysis according to the present invention, each of the plurality of discharge modules may include a first quantitative valve part for regulating a supply amount of blood to mix and discharge the blood and a reagent, And a second metering valve unit.

In the multi-dispenser for automatic hemocyte analysis according to the present invention, the control module may include a storage unit for storing information on the amount of blood and a reagent for blood test, Or a second control valve for controlling the second metering valve unit.

In the multi-dispenser for automatic hematology analysis according to the present invention, the control unit controls the second metering valve unit to operate after operating the first metering valve unit.

Further, in the multi-dispenser for automatic blood group analysis according to the present invention, the discharging module may further include a mixing pipe for mixing the reagent and the blood discharged through the first and second metering valve portions, A reagent supply path for supplying a reagent is provided in the second metering valve portion, and the multi-dispenser further includes a cleaning module for cleaning the reagent supply path .

Further, in the multi-dispenser for automatic blood group analysis according to the present invention, a mixing channel is provided in the mixing channel, one end of the mixing channel is connected to the blood supply channel, and the other end of the mixing channel is connected to the reagent supply channel And the blood supplied from the blood storage container is supplied to the needles through an L-shaped channel, and the reagent supplied from the reagent storage container is supplied to the needle Is supplied.

Further, in the multi-dispenser for automatic hemocyte analysis according to the present invention, the plurality of discharge modules are provided with a suction unit having a suction needle for sucking blood stored in a blood storage container, and a plurality of reagent storage containers, respectively, And a plurality of discharge portions having discharge needles for discharge.

Further, in the multi-dispenser for automatic hematology analysis according to the present invention, the suction unit and the plurality of discharge units are connected by a connection pipe, the plurality of discharge units are each provided with a metering valve, and the metering valve is controlled by the control module .

delete

delete

delete

As described above, according to the multi-dispenser for automatic hematology analysis and its discharging method according to the present invention, since a plurality of discharge modules are mounted on the dispenser unit, a large number of diagnostic specimens can be generated at a high speed by one operation, Thus, the effect of reducing the fatigue of the automatic hematology analyzer is obtained.

In addition, according to the multi-dispenser for automatic hemocyte analysis and the discharging method thereof according to the present invention, since the dispenser unit is provided with a plurality of discharging modules, it is possible to reduce the contact frequency between the discharging needle and the reagent, Effect is also obtained.

1 is a schematic view for explaining a configuration of a dispenser unit provided in a conventional automatic hemocyte analyzer,
FIG. 2 is a configuration diagram of a multi-dispenser for automatic hematology analysis according to a first embodiment of the present invention,
3 is a view for explaining a multi-dispenser for automatic hematology analysis according to the first embodiment,
4 is a block diagram of a multi-dispenser for automatic hematology analysis according to the first embodiment,
5 is a block diagram for explaining the configuration of the control module shown in FIG. 4,
6 is a configuration diagram of a multi-dispenser for automatic hematology analysis according to a second embodiment of the present invention,
FIG. 7 is a flow chart for explaining a method of mixing blood and a reagent in a multi-dispenser for automatic hematology analysis according to the present invention.

These and other objects and novel features of the present invention will become more apparent from the description of the present specification and the accompanying drawings.

Hereinafter, the configuration of the present invention will be described with reference to the drawings.

The term 'module' as applied to the present invention means that the device, component or apparatus is set to be part of a larger apparatus or apparatus with one or more parts or independent apparatuses. This module works with other modules to perform one or more tasks such as independent or diagnostic analysis.

&Quot; Reagent " as applied to the present invention refers to the entirety of the original sample or any portion thereof, unless the context clearly indicates otherwise, and the reagent compound is selected in an amount suitable for the target analysis so as to be chemically mutually friendly. This compound can be selected from the compounds conventionally used in the prior art. For example, a commercially available preparation containing a commercially available preparation, a compound for dissolving red blood cells and a leukocyte protective compound conventionally used for performing leukocyte differentiation is used, and a third reagent compound for stabilizing hemoglobin in the form of a colored complex May be added.

The 'sample' applied to the present invention means that a predetermined amount of blood and a predetermined amount of reagent are mixed for blood test.

FIG. 3 is a view for explaining a multi-dispenser for automatic hematology analysis according to the first embodiment, FIG. 4 is a view for explaining a first dispenser for automatic hemocyte analysis according to the first embodiment of the present invention, FIG. 5 is a block diagram for explaining the configuration of the control module shown in FIG. 4. FIG. 5 is a block diagram of a multi-dispenser for automatic hematology analysis according to an embodiment.

2 to 4, the multi-dispenser for automatic hematology analysis according to the first embodiment of the present invention includes an X-axis moving unit 12 provided on a support 11, an X-axis moving unit 12, A dispenser unit 140 mounted on the Z-axis moving unit 13 and movable up and down and discharging blood or blood and reagents to a plurality of sample storage containers; And a control module (500) for controlling the dispenser unit (140) to adjust the amount of reagent discharged to the plurality of sample storage containers according to the amount of the reagent, wherein the dispenser unit (140) 300 are mounted.

In addition, in the first embodiment of the present invention, a blood storage container 100 for storing blood for diagnosis, a reagent storage container 200 for storing reagents for blood testing for the multi-dispenser for automatic blood cell analysis, A plurality of sample storage vessels 400 are provided for storing test samples mixed in the module 300, respectively.

The blood storage container 100 is a test tube for collecting and storing the blood of an examinee for normal blood diagnosis, and is kept sealed by the cap. 3, the barcode 110 for blood is attached to the blood storage container 100, and the information on the inspector for blood test and the diagnosis name for diagnosis is stored in the barcode 110 for blood , And read by a bar code reader provided in the diagnostic apparatus during the transfer process for inspection.

The reagent storage container 200 is a container for storing a reagent that reacts with blood stored in the blood storage container 100, and is not limited to a specific shape. Such a reagent storage container may be provided with a plurality of reagent types, for example, a reagent for diagnosing leukocyte, a reagent for diagnosing red blood cells, a reagent for diagnosing hemoglobin, and the like. 3, a reagent bar code 210 is attached to the reagent storage container 200. The reagent bar code 210 is provided with information on the reagent, for example, the kind of the reagent, An effective period, remaining capacity, and the like. The reagent bar code 210 is read by a bar code reader provided in the diagnostic apparatus, and the read information is transmitted to the control module 500.

The blood stored in the blood storage container 100 and the reagent stored in the reagent storage container 200 are withdrawn by a conventional withdrawal mechanism (not shown), and are supplied to a plurality of discharge modules 300 . Thus, the drawing mechanism can be integrally coupled to the discharge module. Although the respective discharging modules 300 shown in FIG. 3 have a structure in which the blood and the reagents are respectively supplied by the drawing mechanism, the present invention is not limited thereto, As shown in Fig.

As shown in FIG. 3, each of the discharge modules 300 includes a first metering valve unit 310 for adjusting the supply amount of blood supplied from the drawing mechanism and supplied to the sample storage container 400, A second metering valve unit 320 for adjusting the supply amount of the reagent supplied to the sample storage vessel 400, and a mixing pipe 330. 3, the first metering valve unit 310 is provided with a blood injection port 311 through which blood drawn out from the blood storage container 100 is injected, and the second metering valve unit 320 is provided with a reagent reservoir A reagent injection port 321 through which the reagent withdrawn from the container 200 is injected is provided. 3 shows a structure in which the blood injection port 311 and the reagent injection port 321 are provided in the respective discharge modules 300. The blood injection port 311 and the reagent injection port 321 are shared by the dispenser unit 140, May be provided.

The first metering valve unit 310 is provided with a blood supply path 312 for supplying blood and the second metering valve unit 320 is provided with a reagent supply path 322 for supplying a reagent, An orifice plate is provided at an outlet portion of the valve portion 310 and the second metering valve portion 320 toward the mixing pipe 330. Therefore, the blood injected into the blood supply path 312 by the orifice plate and the reagent injected into the reagent supply path 322 are temporarily held on the supply path, and the first metering valve part 310 or the second metering valve And is discharged to the mixing pipe 330 by the operation of the part 320.

One end of the mixing channel is connected to the blood supply channel 312 and the other end of the mixing channel is connected to the reagent supply channel 322.

The discharging needle 331 for discharging the mixed sample to the sample storage container 400 for storing the mixed sample in the mixing channel of the mixing tube 330 is attached to the lower part of the other channel of the mixing channel, As shown in Fig. 3, the blood supplied from the blood storage container 100 is supplied to the needle 331 through a substantially L-shaped flow path, and the reagent supplied from the reagent storage container 200 is supplied to the needle 331 in a substantially straight line To the needle 331.

The first metering valve unit 310 or the second metering valve unit 320 includes a hydraulic circuit and a solenoid valve, a hydraulic cylinder, or a pneumatic cylinder, each of which operates by an electric signal from the control module 500 . The operation of the first metering valve unit 310 or the second metering valve unit 320 is the same as that of a normal metering valve, and is operated by a hydraulic cylinder or a pneumatic cylinder, so a detailed description thereof will be omitted.

In the meantime, in the multi-dispenser for automatic hematology analysis according to the present invention, when the reagent is changed and injected, a cleaning module 600 for cleaning the reagent supply path 321 is provided.

When the reagent is changed, the reagent supply path 322 by the cleaning module 600 is changed to the reagent supply path 322 because the blood is supplied through the L-shaped channel for supplying the sample to the sample storage container 400, ) Can be performed, so that the cleaning operation can be easily performed. That is, when the blood and the reagent are supplied to the drain module 300, the blood is supplied to the blood supply path 312 after the reagent is supplied through the reagent supply path 322, so that the reagent supply by the cleaning module 600 The cleaning of the furnace 322 can be easily accomplished by cleaning only the linear portion.

Such a cleaning module 600 can be easily realized by a cleaning device of an ordinary diagnostic device.

3, the inner diameter of the blood supply path 312 and the inner diameter of the reagent supply path 322 are substantially the same. However, the inner diameter of the blood supply path 312 and the inner diameter of the reagent supply path 322 are not limited thereto, The length of the blood supply path 312 is longer than the length of the reagent supply path 322 so that the inner diameter of the blood supply path 312 is longer than the inner diameter of the reagent supply path 322 It may be formed narrowly.

The sample storage container 400 is provided with a plurality of sample storage containers 400 corresponding to the reagent amount or reagent type according to the type of diagnosis by the inspector for the purpose of quality control, It is preferable that the test tube is kept sealed by the cap. Also, as shown in FIG. 3, the sample storage container 400 is also equipped with a bar code, so that the examination targets of the sample can be discriminated and confirmed.

5, the control module 500 includes a storage unit 510 for storing information on the amount of blood and a reagent for blood testing, and a dispenser unit 510, And a control unit 520 for controlling the first metering valve unit 310 or the second metering valve unit 320 in the respective discharge modules 300 of the metering valve unit 140.

The storage unit 510 is constituted by a conventional memory device and stores information on the type of the reagent, information on the blood diagnosis, degree of the amount of the reagent to be injected according to the blood diagnosis, and the like. The control unit 520 is configured by a microprocessor and controls the hydraulic circuit provided in the first metering valve unit 310 and the second metering valve unit 320 in response to information stored in the storage unit 510, To control the solenoid valve. When the control unit 520 receives an instruction to change the reagent, the control unit 520 controls the cleaning module 600 by referring to the information stored in the memory 510 to facilitate the cleaning of the reagent supply path 322 .

The control unit 520 controls the second metering valve unit 320 in each of the discharge modules 300 of the dispenser unit 140 according to the information of the reagent barcode 210 defining the reagent in the reagent storage container 200, To control the amount of the reagent to be discharged.

Next, a second embodiment according to the present invention will be described with reference to Fig.

6 is a configuration diagram of a multi-dispenser for automatic hematology analysis according to a second embodiment of the present invention.

In the multi-dispenser for automatic hematology analysis shown in FIG. 6, only the structure of the discharging module 300 'mounted on the dispenser unit 140 is different, and the remaining structure is the same as that of the first embodiment, It is omitted.

6, the discharging module 300 'according to the second embodiment of the present invention includes one suction portion 350 having a suction needle 351 for sucking blood stored in the blood storage container 100 And a plurality of discharge units 360 each having a discharge needle 331 for discharging a predetermined amount of blood to a plurality of reagent storage containers 200.

The suction unit 350 and the plurality of discharge units 360 are connected to each other by a connection pipe 361. A plurality of discharge units 360 are each provided with a metering valve which is controlled by the control unit 520 Respectively.

Therefore, the blood sucked in the suction unit 350 is supplied to the plurality of discharge units 360 by the connection pipe 361, is temporarily held in the blood supply path provided in the metering valve, and the control of the control unit 520 To the plurality of reagent storage containers 200 through the discharge needle 331 by the operation of the metering valve according to FIG.

Also, as shown in FIG. 6, the control unit 520 can control the supply amounts of blood differently according to the types of the reagents.

As described above, according to the first and second embodiments of the present invention, generation of a plurality of samples is performed by a single operation of the dispenser unit 140, so that repeated use of the X- It is possible not only to prevent fatigue of the equipment but also to prevent the contact between the needles and the reagent, thereby realizing the quality control of blood cell analysis.

Next, an example of a method for mixing and discharging blood and a reagent in a multi-dispenser for automatic hemocyte analysis according to the first embodiment of the present invention will be described with reference to FIG.

FIG. 7 is a flowchart illustrating a method of mixing and discharging blood and a reagent in a multi-dispenser for automatic hemocyte analysis according to the present invention.

A method for mixing and discharging blood and a reagent according to the present invention is a method for withdrawing and mixing blood and a reagent in a blood storage container for storing blood and a plurality of reagent storage containers for respectively storing a plurality of reagents for blood testing, A predetermined amount of blood for blood testing is taken out from the storage container 100 (S100).

The control unit 520 determines a blood supply amount in accordance with the instruction inputted to execute the blood diagnosis in step S110 and controls the plurality of discharge modules 300 provided in the dispenser unit 140, 310). That is, the amount of supply (discharge) of blood drawn out of the blood storage container 100 and held in the blood supply path 312 through the blood injection port 311 is determined, and accordingly, And controls the first metering valve unit 310 in the module 300.

In addition, a predetermined amount of reagent for blood test is taken out from the reagent storage container 200 (S200). The control unit 520 determines the supply amount of the reagent in accordance with the command inputted to execute the blood diagnosis in step S210 and controls the second metering valve unit 320 in the plurality of the discharge modules 300 provided in the dispenser unit 140, . In other words, the supply of the reagent held in each of the reagent supply paths 322 in the plurality of discharge modules 300 drawn out from the blood storage container 100 and provided in the dispenser unit 140 through the reagent injection port 321 And controls each of the second metering valve units 320 in a plurality of discharge modules 300 provided in the dispenser unit 140. [

The determination of the supply (discharge) amount of the reagent in the control unit 520 may be performed by a user instruction of the diagnostic apparatus to which the present invention is applied, memory information stored in the storage unit 510, And the second quantitative valve part 320 is controlled by a plurality of discharge modules 300 provided in the dispenser unit 140 according to the information of the reagent barcode 210 defining the reagent, And the like.

The blood and the reagent are discharged by the control of each of the first metering valve unit 310 and the second metering valve unit 320 in the plurality of discharge modules 300 and the blood and the reagent (S300) and stored in a plurality of sample storage vessels (400) via a needle (331) provided in the mixing tube (330).

The control of each of the first metering valve units 310 in the plurality of discharge modules 300 by the control unit 520 in the step S120 and the control of each of the plurality of discharge modules 300 by the control unit 520 in the step S220 The control of the second metering valve unit 320 of the second metering valve unit 320 can be performed simultaneously. However, the present invention is not limited to this, and the controller 520 may control the first metering valve unit 310 and then the control unit 520 sequentially control the second metering valve unit 320.

In addition, in step S220, the control unit 520 may control the plurality of the second metering valve units 320 in the plurality of the discharge modules 300 such that the amounts of the reagents drawn out from the plurality of reagent storage vessels 400 are different from each other. As shown in Fig.

Next, when the kind of the reagent is changed and withdrawn in the plurality of reagent storage containers 200 for the same blood after the step S310 (S320), the reagent supply passages 321 in the plurality of the drainage modules 300, (S340). Then, the process proceeds to step S210 and the above-described process is repeated.

In the above description, the configuration for changing the amount of reagent and the type of reagent for the same blood has been described. However, the present invention is not limited to this, and the same reagent may be applied to other blood. That is, in the above description, the amount of blood supplied through the first metering valve unit 310 is controlled and the supply amount of the reagent is controlled through the second metering valve unit 320. However, in the first metering valve unit 310, The amount of blood supplied through the second metering valve unit 320 may be controlled.

If the cleaning is not performed in step S320, the process is terminated (S330). However, it is preferable to clean the entire exhaust module 300 for mixing of another blood and a reagent, rather than a simple termination like this.

Although the present invention has been described in detail with reference to the above embodiments, it is needless to say that the present invention is not limited to the above-described embodiments, and various modifications may be made without departing from the spirit of the present invention.

By using the multi-dispenser for automatic hematology analysis according to the present invention, it is possible to generate a large number of diagnostic specimens at a high speed.

11: Support
12: X-axis moving unit
13: Z-axis moving unit
140: dispenser unit
300, 300 ': Discharge module

Claims (10)

An X-axis moving unit provided on the support,
A Z-axis moving unit provided in the X-axis moving unit,
A dispenser unit mounted on the Z-axis moving unit and movable up and down, for discharging blood or blood and reagents to a plurality of sample storage containers,
And a control module for controlling the dispenser unit to regulate the amount of blood or reagent discharged into the plurality of sample storage containers according to the type of reagent or the amount of the reagent,
The dispenser unit is equipped with a plurality of discharge modules,
Wherein each of the plurality of exhaust modules includes a first metering valve portion for regulating a supply amount of the blood to mix and discharge the blood and the reagent,
And a second quantitative valve unit for regulating a supply amount of the reagent. delete The method of claim 1,
The control module may include a storage unit for storing information on the amount of blood and a reagent for blood test, and a control unit for controlling the first metering valve unit or the second metering valve unit according to the information stored in the storage unit Multi-dispenser for automatic hematology analysis. 4. The method of claim 3,
Wherein the controller controls the second metering valve unit to operate after operating the first metering valve unit. The method of claim 1,
Wherein the discharge module further comprises a mixing tube for mixing the reagent and the blood discharged through the first and second metering valve portions,
Wherein the first metering valve unit is provided with a blood supply path for supplying blood and the second metering valve unit is provided with a reagent supply path for supplying reagents,
Wherein the multi-dispenser further comprises a cleaning module for cleaning the reagent supply path. The method of claim 5,
The mixing channel is provided with a mixing channel, one end of the mixing channel is connected to the blood supply channel, the other end of the mixing channel is connected to the reagent supply channel, and a needle is attached to the lower portion of the other channel ,
Blood supplied from the blood storage container is supplied to the needles through an L-shaped channel,
Wherein the reagent supplied from the reagent storage container is supplied to the needle linearly. delete delete delete delete
KR1020160012750A 2016-02-02 2016-02-02 Multi dispenser for automated hematology analyzer KR101807746B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020160012750A KR101807746B1 (en) 2016-02-02 2016-02-02 Multi dispenser for automated hematology analyzer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020160012750A KR101807746B1 (en) 2016-02-02 2016-02-02 Multi dispenser for automated hematology analyzer

Publications (2)

Publication Number Publication Date
KR20170091898A KR20170091898A (en) 2017-08-10
KR101807746B1 true KR101807746B1 (en) 2017-12-13

Family

ID=59652383

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020160012750A KR101807746B1 (en) 2016-02-02 2016-02-02 Multi dispenser for automated hematology analyzer

Country Status (1)

Country Link
KR (1) KR101807746B1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102101559B1 (en) 2017-07-20 2020-04-17 주식회사 엘지화학 Compound and organic light emitting device comprising the same
KR102022054B1 (en) * 2017-08-29 2019-09-18 신진메딕스(주) Automatic dispenser

Also Published As

Publication number Publication date
KR20170091898A (en) 2017-08-10

Similar Documents

Publication Publication Date Title
US20230185070A1 (en) Automated microscopic cell analysis
JP7315458B2 (en) automated microscopic blood cell analysis
CN102998474B (en) Method for employing apparatus for aspirating and dispensing liquids in automated analyzer
CN103728461B (en) Liquid relief pipe unit and the method for aspirating test liquid
US11478789B2 (en) Automated microscopic cell analysis
US11590496B2 (en) Automated microscopic cell analysis
US9217750B2 (en) Sample processing apparatus and cleaning method
US8663559B2 (en) Sample analyzer, sample analyzing method, and computer program product
EP0739478B1 (en) Method and apparatus for analysing a liquid sample
US20190391171A1 (en) Blood measuring device control method
EP2224224B1 (en) Reagent preparing device, specimen processing system and reagent preparing method
KR20160137359A (en) A cell detection apparatus and a method for cell detection
CN108732135A (en) A kind of blood cell and analysis of protein device
EP4220121A1 (en) Apparatus for quantitatively treating liquid
JP6124285B2 (en) Circulating cancer cell trap
KR101807746B1 (en) Multi dispenser for automated hematology analyzer
JPH04115136A (en) Particle measuring apparatus
CN111433584B (en) Diluent preparation module and unit
CN108732338A (en) A kind of classification of compatible leucocyte five and leucocyte three divide the cellanalyzer and test method of group
CN211978707U (en) Specific protein analyzer
KR101762877B1 (en) Mixing apparatus of blood and reagent
KR101762868B1 (en) Multi dispenser for automated hematology analyzer
JPH06130072A (en) Automatic analyzer
CN110967322A (en) Blood cell analyzer and blood cell analyzing method
CN116087542A (en) Sample analyzer and sample detection method

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant