CN116106525A - Blood analyzer - Google Patents

Blood analyzer Download PDF

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Publication number
CN116106525A
CN116106525A CN202310390947.7A CN202310390947A CN116106525A CN 116106525 A CN116106525 A CN 116106525A CN 202310390947 A CN202310390947 A CN 202310390947A CN 116106525 A CN116106525 A CN 116106525A
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unit
reagent
sample preparation
same
channels
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CN116106525B (en
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宋一纨
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Shenzhen Dymind Biotechnology Co Ltd
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Shenzhen Dymind Biotechnology Co Ltd
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The application discloses blood analyzer, including detecting pond unit, shared pipeline, N first gate valve and N sample preparation passageway, N is not less than 2 and N is the integer, and wherein N first gate valve and N sample preparation passageway one-to-one. The shared pipeline is used for receiving samples prepared by the N sample preparation channels in a time-sharing mode and conveying the corresponding samples to the detection cell unit; the detection pool unit is respectively connected with the N sample preparation channels through the sharing pipeline and is used for allowing the samples provided by the sharing pipeline to pass through so as to detect the samples. Based on the mode, the N sample preparation channels can detect the samples of each sample preparation channel by using the detection cell units in a time-sharing mode through the control of the N first gating valves, namely, the samples of the N sample preparation channels can share one detection cell unit for detection, so that the channel consistency among different sample preparation channels of the blood analyzer is greatly improved.

Description

Blood analyzer
Technical Field
The present application relates to the field of detection technology, and in particular to a blood analyzer.
Background
In the prior art, along with the increasing blood detection demands of people, when a blood analyzer is adopted to analyze various blood samples, a plurality of independent detection channels are arranged in the blood analyzer so as to complete various analyses of the blood samples. Different detection channels have different detection requirements, and each channel is required to be provided with a plurality of matching components such as driving components and connectors.
The defects of the prior art are that more detection channels and corresponding matched components are required to be equipped to meet more detection requirements, so that the whole structure of the sample analyzer is complex and the control difficulty of the components is high.
Disclosure of Invention
The technical problem that this application mainly solves is how to simplify sample analysis appearance overall structure, reduce the control degree of difficulty of blood analysis appearance's ware part.
In order to solve the technical problem, a first technical scheme adopted in the application is as follows: a blood analyzer, comprising: the blood analyzer comprises a detection pool unit, a shared pipeline, N first gating valves and N sample preparation channels, wherein N is not less than 2 and is an integer, and the N first gating valves are in one-to-one correspondence with the N sample preparation channels; the sample preparation channel is used for preparing different samples; each first gating valve is used for switching a conduction state and a blocking state between the corresponding sample preparation channel and the shared pipeline, and each first gating valve is correspondingly connected in series between one sample preparation channel and the shared pipeline; the shared pipeline is used for receiving the samples prepared by the N sample preparation channels in a time-sharing mode and conveying the corresponding samples to the detection cell unit; the detection pool unit is respectively connected with N sample preparation channels through the shared pipeline and is used for allowing samples provided by the shared pipeline to pass through so as to detect the samples; the opening and closing performances of the N first gating valves are the same, and in the starting-up state of the blood analyzer, the states of all the N first gating valves only comprise two types: all N first gate valves are fully blocked and only one of the first gate valves is on.
Wherein the sample preparation channel comprises a first reagent unit, a second reagent unit and a reaction tank unit; the reaction tank unit is respectively connected with the first reagent unit and the second reagent unit, and is connected with the shared pipeline through the first gating valve; the first reagent unit and the second reagent unit are used for supplying corresponding reagents to the reaction tank unit, and the reaction tank unit is used for receiving the reagents respectively supplied by the first reagent unit and the second reagent unit and receiving a sample so as to mix the received reagents with the sample to form the sample; in the reaction tank unit, the inlet caliber connected with the first reagent unit is different from the inlet caliber connected with the second reagent unit, and/or the pipe diameter connected with the first reagent unit is different from the pipe diameter connected with the second reagent unit and the reaction tank unit, and/or the pipe length connected with the first reagent unit and the reaction tank unit is different from the pipe length connected with the second reagent unit and the reaction tank unit.
The first reagent unit and the second reagent unit comprise a quantitative liquid sucking and discharging unit, a reagent accommodating unit, a second gating valve and a third gating valve, and the blood analyzer further comprises a positive pressure source and a negative pressure source; the second gating valve is respectively connected with the quantitative liquid sucking and discharging unit, the reagent accommodating unit and the reaction tank unit, and when the second gating valve is in a first state, the quantitative liquid sucking and discharging unit is used for sucking corresponding reagent from the reagent accommodating unit; when the second gating valve is in a second state, the quantitative liquid sucking and discharging unit injects the sucked reagent into the reaction tank unit; the quantitative liquid sucking and discharging unit is connected with the positive and negative pressure source through the third gating valve; wherein the amount of reagent that the quantitative pipetting unit suctions from the reagent accommodating unit when the second gate valve is in the first state is equal to the amount of reagent that the quantitative pipetting unit injects into the reaction tank unit when the second gate valve is in the second state, the blood analyzer further comprising: the first liquid sucking and discharging unit is connected with the shared pipeline and the waste liquid discharging part through the fourth gating valve, and the first liquid sucking and discharging unit is connected with the positive and negative pressure source through the fifth gating valve.
Wherein in the same sample preparation channel, the quantitative driving performance of the quantitative liquid sucking and discharging unit in the first reagent unit is different from the quantitative driving performance of the quantitative liquid sucking and discharging unit in the second reagent unit; and/or the opening and closing performances of the second gate valves in all the first reagent units are the same in different sample preparation channels, and/or the opening and closing performances of the third gate valves in all the first reagent units are the same in different sample preparation channels, and/or the opening and closing performances of the second gate valves in all the second reagent units are the same in different sample preparation channels, and/or the opening and closing performances of the third gate valves in all the second reagent units are the same in different sample preparation channels, and/or the quantitative driving performances of the quantitative liquid sucking and discharging units in all the first reagent units are the same in different sample preparation channels; and/or, in different sample preparation channels, the quantitative driving performance of the quantitative liquid sucking and discharging units in all the second reagent units is the same.
The first reagent unit and the second reagent unit comprise a reagent suction pipe and a reagent supply pipe, the reagent accommodating unit is connected with the quantitative liquid sucking and discharging unit through the reagent suction pipe, and the quantitative liquid sucking and discharging unit is connected with the reaction tank unit through the reagent supply pipe; the first characteristic parameters of the reagent suction pipes of all the first reagent units are the same; and/or, second characteristic parameters of the reagent supply pipes of all the first reagent units are the same; and/or, third characteristic parameters of the reagent suction pipes of all the second reagent units are the same; and/or fourth characteristic parameters of the reagent supply pipes of all the second reagent units are the same; and/or at least one first characteristic subparameter of the first characteristic parameters of the reagent aspiration tube of the first reagent unit and at least one third characteristic subparameter of the third characteristic parameters of the reagent aspiration tube of the second reagent unit are different in the same sample preparation channel; and/or at least one second characteristic sub-parameter of the second characteristic parameters of the reagent supply tube of the first reagent unit is different from at least one fourth characteristic sub-parameter of the fourth characteristic parameters of the reagent supply tube of the second reagent unit in the same sample preparation channel.
Wherein the electrical parameters of the second gating valves in the first reagent units and the third gating valves are the same in the same sample preparation channel, and/or the electrical parameters of the second gating valves in the second reagent units and the third gating valves are the same in the same sample preparation channel, and/or the electrical parameters of the second gating valves in all the first reagent units are the same in different sample preparation channels, and/or the electrical parameters of the third gating valves in all the first reagent units are the same in different sample preparation channels; and/or the electrical parameters of the second gating valves in all the second reagent units are the same in different sample preparation channels, and/or the electrical parameters of the third gating valves in all the second reagent units are the same in different sample preparation channels; and/or the fourth gate valve and the fifth gate valve of the first liquid sucking and discharging unit have the same electrical parameters; and/or the electrical parameters of the fourth gate valve of the first liquid sucking and discharging unit are the same as the electrical parameters of at least one of the second gate valves in the N sample preparation channels; and/or the electrical parameters of the fifth gating valve of the first liquid sucking and discharging unit are the same as the electrical parameters of at least one third gating valve in the N sample preparation channels; and/or, in different sample preparation channels, the electrical interfaces of the N first gate valves are connected with the same circuit board, and each first gate valve is driven by a MOS transistor or triode with the same electrical parameter, and/or, in different sample preparation channels, the electrical interfaces of the N second gate valves are connected with the same circuit board, and each second gate valve is driven by a MOS transistor or triode with the same electrical parameter, and/or, in different sample preparation channels, the electrical interfaces of the N third gate valves are connected with the same circuit board, and each third gate valve is driven by a MOS transistor or triode with the same electrical parameter.
Wherein the blood analyzer further comprises a control unit, a driving unit and a cleaning unit; the driving unit is connected with the detection pool unit through a shared pipeline, and the cleaning unit is connected with the detection pool unit through the shared pipeline; the control unit is used for: when only one of the first gating valves is conducted, the sample preparation channel corresponding to the first gating valve in the conducted state is used for carrying out sample conveying under the driving action of the driving unit or is cleaned at least through the cleaning unit; and/or when all N first gating valves are blocked, the shared pipeline and/or the detection pool unit are/is cleaned by the cleaning unit.
When only one of the first gating valves is conducted and the sample preparation channel corresponding to the first gating valve in the conducted state carries out sample conveying, the sample in the sample preparation channel flows to the shared pipeline from the sample preparation channel through the conducted first gating valve; when only one of the first gate valves is conducted and the sample preparation channel corresponding to the first gate valve in the conducted state is at least cleaned by the cleaning unit, the cleaning liquid of the cleaning unit flows to the sample preparation channel through the shared pipeline and the conducted first gate valve.
Wherein, at least two corresponding reaction tank units of the sample preparation channel are assembled and connected in a multi-connected tank mode.
Wherein the sample preparation channel further comprises a preheating part and a cleaning liquid supply unit, and the cleaning liquid supply unit is connected with the reaction tank unit; the preheating part is used for heating the reagent supplied by the first reagent unit, and/or used for heating the reagent supplied by the second reagent unit, and/or used for heating the cleaning liquid supplied by the cleaning liquid supply unit.
The beneficial effects of this application lie in: in the technical scheme of the application, the shared pipeline is used for receiving samples prepared by N sample preparation channels in a time-sharing mode and conveying corresponding samples to the detection cell unit; the detection pool unit is respectively connected with the N sample preparation channels through the sharing pipeline and is used for allowing the samples provided by the sharing pipeline to pass through so as to detect the samples. Based on the mode, the N sample preparation channels can transport the sample of each sample preparation channel by controlling the N first gating valves by using the shared pipeline in a time-sharing way, and the sample of each sample preparation channel is detected by using the detection pool unit in a time-sharing way, namely, the samples of the N sample preparation channels can share one shared pipeline for preparation before sample detection, the samples of the N sample preparation channels can share one detection pool unit for sample detection in a time-sharing way, and the arrangement of sample preparation and sample detection in a time-sharing way simplifies the connection relation of matched components and connectors of multiple detection channels in the blood analyzer and simplifies the structure of the blood analyzer; the opening and closing performances of the N first gating valves are the same, the starting state of the blood analyzer comprises that all N first gating valves are blocked completely, only one first gating valve is conducted, the structural consistency and the control mode consistency of the first gating valve corresponding to each sample preparation channel are guaranteed, the stability and the consistency of a liquid conveying path of each sample preparation channel are further guaranteed, the instability caused by the fact that parameters of sample output prepared by different preparation channels need to be corrected mutually is reduced, and the condition that the parameter output corrected mutually and the expected value of each channel are inconsistent is reduced.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for the description of the embodiments will be briefly described below, and it is apparent that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of a first embodiment of a blood analyzer of the present application;
FIG. 2 is a schematic diagram of a first embodiment of a sample preparation channel of the present application;
FIG. 3 is a schematic diagram of a second embodiment of a sample preparation channel of the present application;
FIG. 4 is a schematic diagram of a first embodiment of a first or second reagent unit of the present application;
FIG. 5 is a schematic diagram of a second embodiment of a hematology analyzer of the present application;
FIG. 6 is a schematic diagram of a frame of a second embodiment of a first reagent unit or a second reagent unit of the present application;
FIG. 7 is a schematic diagram of a third embodiment of a hematology analyzer of the present application;
fig. 8 is a schematic view of a splice of a first embodiment of a reaction cell unit of the present application.
Detailed Description
The present application is described in further detail below with reference to the drawings and examples. It is specifically noted that the following examples are only for illustration of the present application, but do not limit the scope of the present application. Likewise, the following embodiments are only some, but not all, of the embodiments of the present application, and all other embodiments obtained by one of ordinary skill in the art without making any inventive effort are within the scope of the present application.
Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment may be included in at least one embodiment of the present application. The appearances of such phrases in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. Those of skill in the art will explicitly and implicitly appreciate that the embodiments described herein may be combined with other embodiments.
In the description of the present application, it is to be understood that the terms "mounted," "configured," "connected," and "connected" are to be interpreted broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected, unless explicitly stated and defined otherwise; the connection can be mechanical connection or electric connection; may be directly connected or may be connected via an intermediate medium. It will be apparent to those skilled in the art that the foregoing is in the specific sense of this application.
Referring to fig. 1, fig. 1 is a schematic diagram of a first embodiment of a blood analyzer of the present application, the blood analyzer includes a detection cell unit 11, a shared pipeline 12, N first gate valves 13 and N sample preparation channels 14, N is not less than 2 and N is an integer, wherein the N first gate valves 13 and the N sample preparation channels 14 are in one-to-one correspondence.
The detection tank unit 11 is located at one end of the shared pipeline 12, and is used for detecting the liquid to be detected in the detection tank unit 11. The liquid to be measured is one of N sample preparation channels for conveying.
The sample preparation channel 14 is used to prepare different samples. The sample is a liquid to be measured obtained by mixing a reagent with blood or body fluid extracted from a subject to be tested for detection.
Each first gate valve 13 is used for switching the conducting state and the blocking state between the corresponding sample preparation channel 14 and the shared pipeline 12, and each first gate valve 13 is correspondingly connected in series between one sample preparation channel 14 and the shared pipeline 12.
One end of the first gating valve 13 is connected with the sample preparation channel 14, the other end of the first gating valve 13 is connected with the shared pipeline 12, the first gating valve 13 can be switched into a conducting state or a blocking state, and when the first gating valve is in the conducting state, the corresponding sample preparation channel 14 and the shared pipeline 12 are mutually conducted; in the blocking state, the corresponding sample preparation channel 14 and the shared line 12 are not in communication with each other.
Specifically, N sample preparation channels 14 are sequentially distributed from one end of the shared pipeline 12 along the extending direction of the shared pipeline 12 through the access points of the corresponding first gate valves 13 on the shared pipeline 12, and the extending direction is a direction away from the detection cell unit 11.
The shared line 12 is used for receiving samples prepared by the N sample preparation channels 14 in a time-selective manner and for conveying the corresponding samples to the detection cell unit 11.
At a certain moment, the first gate valves 13 are in a conducting state, the rest of the first gate valves 13 are in a blocking state, and samples prepared by the corresponding sample preparation channels 14 are conveyed to the detection cell unit 11 through the shared pipeline 12. At another moment, the other first gate valve 13 is in a conducting state, the other first gate valves 13 are in a blocking state, and the samples prepared by the corresponding sample preparation channels 14 are conveyed to the detection cell unit 11 through the shared pipeline 12. After N times, the samples prepared by the N sample preparation channels 14 are each individually transported to the detection cell unit 11 at different times. The types and the number of sample preparation channels required for preparing the samples are different according to different detection requirements of each sample, the sample detection of one sample is not required, the types and the number of the sample preparation channels required for preparing the samples are limited, and the corresponding sample detection can be specifically performed according to actual conditions.
The detection cell unit 11 is connected to N sample preparation channels 14 through the shared pipeline 12, and the detection cell unit 11 is used for allowing the sample provided by the shared pipeline 12 to pass through so as to detect the sample. Samples prepared in the N sample preparation channels 14 enter the detection cell unit 11 through the shared line 12 in a time-sharing manner, and are detected by the detection cell unit 11.
The N first gate valves 13 have the same opening and closing performance, and in the on state of the hematology analyzer, the states of all N first gate valves 13 include only two kinds: all N first gate valves 13 are fully blocked or only one of the first gate valves 13 is conducting.
The N first gate valves 13 have the same opening and closing performance, including, but not limited to, the same flow rate of the sample in the corresponding sample preparation channel 14 through the first gate valve 13 into the shared conduit 12 when the first gate valve 13 is in the on state, and/or the start or close delay of each first gate valve when it is desired to open or close, and/or the valve configuration and/or valve function and/or valve chamber volume and/or valve pattern. Alternatively, the N first gate valves 13 may be valves of identical model or electrical parameters. In some embodiments, due to errors in control, assembly, calibration, etc., for the N first gate valves 13, the flow rate of the sample entering the shared pipeline through the corresponding first gate valve when the N first gate valves 13 are turned on, the start or close delay of each first gate valve, the valve configuration, the valve function, the valve chamber internal volume, and the valve pattern are not completely the same due to errors, and when the errors are within a certain error range, the opening and closing performances of the N first gate valves are also considered to be the same.
In an on state of the blood analyzer, comprising: the blood analyzer is in an operating state, and the detecting cell unit 11 needs to detect the samples in the N sample preparation channels 14, where the states of the N first gate valves 13 include only two kinds: when the sample is required to be conveyed to the detection cell unit 11, only one of the first gate valves 13 is conducted; when the detection cell unit 11 has received a sample in one of the sample preparation channels 14, all N first gate valves 13 are fully blocked, preventing other samples from entering the detection cell unit 11.
It should be noted that, in the on state of the blood analyzer, it is not necessary to detect all of the samples in the N sample preparation channels 14, and only a part of the samples in the sample preparation channels 14 may be detected. At this time, however, the states of the N first gate valves 13 include only two kinds: when the sample is required to be conveyed to the detection cell unit 11, only one of the first gate valves 13 is conducted; when the detection cell unit 11 has received a sample in one of the sample preparation channels 14, all N first gate valves 13 are fully blocked, preventing other samples from entering the detection cell unit 11.
In contrast to the prior art, in the solution of the present application, the shared line 12 is used for receiving samples prepared by the N sample preparation channels 14 in a time-selective manner, and for conveying the corresponding samples to the detection cell unit 11; the detection cell unit 11 is connected to N sample preparation channels 14 through the shared line 12, respectively, and the detection cell unit 11 is used for passing the sample provided by the shared line 12 to detect the sample.
The above-described technical solution can ensure channel consistency between different sample preparation channels 14 as much as possible.
First, the N sample preparation channels 14 can transport the samples of each sample preparation channel by controlling the N first gate valves 13 by using the shared pipeline in a time-sharing manner, and detect the samples of each sample preparation channel by using the detection cell unit in a time-sharing manner, that is, means: (1) The samples of the N sample preparation channels can share the same shared pipeline for preparation before sample detection, so that the consistency of sample preparation links is basically ensured;
(2) The samples of the N sample preparation channels can share the same detection cell unit for detecting the samples, so that the consistency of sample detection links in the whole sample detection process is basically ensured;
(3) Besides, the samples of the N sample preparation channels can share some common devices which are not mentioned in the technical proposal, so that the consistency of other links of the sample detection is basically ensured.
The sharing of the shared devices enables the identical devices to be used in as many links as possible in the whole detection process of the samples prepared by the N sample preparation channels 14 when the samples are measured, so that the channel consistency in the whole detection process of the samples of different sample preparation channels is basically ensured.
Secondly, the opening and closing performances of the N first gating valves are the same, so that the consistency of different samples in the N sample preparation channels through the corresponding first gating valves (namely sample transmission links) can be improved, the accuracy of each sample preparation channel 14 is improved, the possibility that the whole parameters of the blood analyzer are inconsistent with the expected conditions is reduced, the accuracy of blood analysis is improved, and the channel consistency of the different sample preparation channels in the whole sample detection process is further ensured.
The starting-up state of the blood analyzer comprises that all N first gating valves are blocked completely, only one of the first gating valves is conducted, the consistency of the control mode of each sample preparation channel is guaranteed, the stability and consistency of the liquid conveying path of each sample preparation channel are further guaranteed, the fluctuation of results caused by the fact that different preparation channels need to be mutually corrected is reduced, the condition that parameter output of mutual correction of each channel is inconsistent with expected is reduced, and the channel consistency of different sample preparation channels in the whole sample detection process is further guaranteed.
It should be noted that the blood analyzer includes a flow cytometer, which is a highly accurate IVD detection device, and corresponds to a solution of a high-end flow cytometer having a plurality of sample preparation channels, and has a very high requirement for channel consistency between different sample preparation channels. In the flow detection, a plurality of analysis channels, such as WDF, WNR, WPC, RET, PLT-F, exist, signals corresponding to different analysis channels are equivalent to signals under different modes, when all the signals are processed and analyzed to obtain a flow detection result, the signals under different modes need to be subjected to information fusion so as to generate a corresponding multidimensional scatter diagram and to perform pattern recognition so as to distinguish different types of blood cells, therefore, in the flow detection, the consistency of signals output by different sample preparation channels is required to be higher, and by accurately controlling dozens or even hundreds of links or control points in the whole sample detection process in all the sample preparation channels, the consistency of the signals under different modes can be effectively improved, and the accuracy of the flow detection result is further improved. The technical scheme ensures that the channel consistency caused by some key technical links in the whole sample detection process of different sample preparation channels is effectively ensured.
In some embodiments of the present application, please refer to fig. 2 and 3, fig. 2 is a schematic diagram of a first embodiment of the sample preparation channel 14 of the present application, and fig. 3 is a schematic diagram of a second embodiment of the sample preparation channel 14 of the present application.
In the above-described embodiment, the sample preparation channel 14 includes the first reagent unit 141, the second reagent unit 142, and the reaction cell unit 143; the reaction tank unit 143 is respectively connected with the first reagent unit 141 and the second reagent unit 142, and the reaction tank unit 143 is connected with the sharing pipeline 12 through the first gating valve 13; the first and second reagent units 141 and 142 are for supplying corresponding reagents to the reaction cell unit 143, and the reaction cell unit 143 is for receiving the reagents supplied by the first and second reagent units 141 and 142, respectively, and receiving a sample such that the received reagents are mixed with the sample to form a sample.
The reaction cell unit 143 is for mixing the reagents respectively supplied from the first reagent unit 141 and the second reagent unit 142 and receiving a sample including blood to be measured to form a sample.
Alternatively, referring to fig. 2, the reaction cell unit 143 is directly connected to the first reagent unit 141 and the second reagent unit 142, and the reaction cell unit 143 directly receives the sample.
Alternatively, referring to fig. 3, an epitaxial tube 1431 is disposed on a sidewall of the reaction cell unit 143, the reaction cell unit 143 is indirectly connected to the first reagent unit 141 and the second reagent unit 142 through the epitaxial tube, the first reagent unit 141 and the second reagent unit 142 have different access ports on the epitaxial tube, and the reaction cell unit 143 receives a sample through the epitaxial tube.
Wherein, in the reaction cell unit 143, an inlet caliber connected with the first reagent unit 141 is different from an inlet caliber connected with the second reagent unit 142, and/or a pipe diameter connected with the first reagent unit 141 and the reaction cell unit 143 is different from a pipe diameter connected with the second reagent unit 142 and the reaction cell unit 143, and/or a pipe length connected with the first reagent unit 141 and the reaction cell unit 143 is different from a pipe length connected with the second reagent unit 142 and the reaction cell unit 143.
The first reagent unit 141 and the second reagent unit 142 are directly connected to the reaction cell unit 143 or the epitaxial tube through different pipes, the pore size of the connection between the pipes and the reaction cell unit 143 or the epitaxial tube is called as an inlet caliber, the pore size of the pipes is called as a pipe diameter, and the length of the pipes is called as a pipe length.
In the reaction cell unit 143, at least one of the inlet aperture connected to the first reagent unit 141 and the inlet aperture, the pipe diameter and the pipe length connected to the second reagent unit 142 is different, because the reagent of the first reagent unit 141 and the reagent of the second reagent unit 142 are different in cost and amount with respect to the preparation of a sample in one sample preparation channel, the inlet aperture and/or the pipe diameter of the pipe corresponding to the reagent with high cost or low amount are small to prevent diffusion, and the small inlet aperture and/or the small pipe diameter of the pipe are beneficial to reducing the occurrence of the situation that the liquid in the part connected to the pipe diffuses into the pipe to pollute the reagent in the pipe, thereby reducing the problem of high reagent consumption caused by large reagent diffusion between the pipes; in the process of transporting the reagent, reagent residues are generated at the positions of transported pipelines, parts and the like, and the lengths of the pipelines are short so as to reduce the loss and waste in the process of transporting the reagent; the inlet caliber and/or the pipe diameter of the pipeline corresponding to the reagent with low cost or large dosage are large, so that the pipe resistance is reduced, the reagent with required quantity is convenient to transport quickly, the efficiency of mixing the reagent and the sample is improved, and the overall reaction efficiency of the blood analyzer is further improved.
In the technical scheme of the application, the reaction tank unit 143 is respectively connected with the first reagent unit 141 and the second reagent unit 142, and the reaction tank unit 143 is connected with the sharing pipeline 12 through the first gating valve 13; the first reagent unit 141 and the second reagent unit 142 are used for supplying corresponding reagents to the reaction tank unit 143, the reaction tank unit 143 is used for receiving the reagents respectively supplied by the first reagent unit 141 and the second reagent unit 142 and receiving a sample, so that the received reagents are mixed with the sample to form a sample, and based on the mode, the first reagent unit 141 and the second reagent unit 142 are respectively provided with different inlet calibers, pipe diameters and/or pipe lengths according to the types and the required amounts of the reagents respectively carried and conveyed and are connected with the reaction tank unit 143 by pipelines, and particularly, the effect of reducing diffusion of the reagents in the conveying process with high cost or small amount is achieved, and the waste of the reagents in the conveying process is reduced.
Referring to fig. 4, fig. 4 is a schematic diagram of a first embodiment of the first reagent unit 141 or the second reagent unit 142.
The first reagent unit 141 and the second reagent unit 142 have similar internal structures, each including a quantitative liquid sucking and discharging unit 144, a reagent accommodating unit 145, a second gate valve 146 and a third gate valve 147, and the blood analyzer further includes a positive and negative pressure source 148. Alternatively, the reagent is disposed in the reagent accommodating unit 145, and the reagent accommodating unit 145 may be a reagent bottle or a reagent bag. In order to ensure the stability of the liquid path control and the consistency of the operation of different sample preparation channels, the positive and negative pressure sources corresponding to the first reagent unit 141 and the positive and negative pressure sources corresponding to the second reagent unit 142 may be the same positive and negative pressure source.
The second gate valve 146 is connected to the quantitative liquid sucking and discharging unit 144, the reagent accommodating unit 145 and the reaction tank unit 143, respectively, and when the second gate valve 146 is in the first state, the quantitative liquid sucking and discharging unit 144 is used for sucking the corresponding reagent from the reagent accommodating unit 145. The second gate valve 146 is in the first state, which means that the reagent accommodating unit 145 is in a conducting state with the passage of the quantitative liquid discharge and suction unit, and the passage of the quantitative liquid discharge and suction unit and the reaction tank unit 143 is in a blocking state, and the pressure in the quantitative liquid discharge and suction unit 144 is changed by the positive and negative pressure source 148, so that the quantitative liquid discharge and suction unit 144 is used for sucking the corresponding reagent from the reagent accommodating unit 145.
Wherein, when the second gate valve 146 is in the second state, the quantitative liquid sucking and discharging unit 144 injects the sucked reagent into the reaction cell unit 143. The second gate valve 146 is in the second state, which means that the reagent accommodating unit 145 is in a blocking state with the passage of the quantitative liquid discharge and suction unit, and the passage of the quantitative liquid discharge and suction unit is in a conducting state with the passage of the reaction tank unit 143, and the pressure in the quantitative liquid discharge and suction unit 144 is changed by the positive and negative pressure source 148, so that the quantitative liquid discharge and suction unit 144 injects the sucked reagent into the reaction tank unit 143.
The quantitative liquid sucking and discharging unit 144 is connected to a positive and negative pressure source 148 through a third gate valve 147, and the positive and negative pressure source 148 controls the pressure inside the quantitative liquid sucking and discharging unit 144 through the third gate valve 147. For example, positive negative pressure source 148 includes a positive pressure source 70 kilopascals and a negative pressure source-40 kilopascals.
Wherein the amount of reagent sucked from the reagent containing unit 145 by the quantitative suction and discharge unit 144 when the second gate valve 146 is in the first state is equal to the amount of reagent injected into the reaction cell unit 143 by the quantitative suction and discharge unit 144 when the second gate valve 146 is in the second state. Alternatively, the quantitative pipetting and drainage unit 144 may be a quantitative pump, and the amounts of reagents for pipetting and drainage each time are equal.
Alternatively, the first reagent unit 141 and the second reagent unit 142 in the same sample preparation channel may include a quantitative pipetting unit 144, a reagent accommodating unit 145, a second gate valve 146 and a third gate valve 147, which may have the same parameters, respectively. For example, the second gate valve 146 and the third gate valve 147 are gate valves of the same parameter, and the quantitative liquid sucking and discharging unit 144 of the first reagent unit 141 and the quantitative liquid sucking and discharging unit 144 of the second reagent unit 142 are quantitative pumps of the same parameter, including the electrical parameter.
Alternatively, in order to ensure that the time response of the on-state and off-state switching is sufficiently accurate, components of the same parameters need to be configured. In this embodiment, the gate valves have the same parameters, the quantitative liquid sucking and discharging units 144 have the same parameters, and the positive and negative pressure sources 148 have the same parameters.
In contrast to the prior art, in the technical solution of the present application, the first reagent unit 141 and the second reagent unit 142 each include a quantitative liquid sucking and discharging unit 144, a reagent accommodating unit 145, a second gate valve 146 and a third gate valve 147, and the blood analyzer further includes a positive and negative pressure source 148. Wherein the amount of reagent sucked from the reagent accommodating unit 145 by the quantitative pipetting and draining unit when the second gate valve 146 is in the first state is equal to the amount of reagent injected into the reaction cell unit 143 by the quantitative pipetting and draining unit 144 when the second gate valve 146 is in the second state. Based on the above manner, by setting the gate valves, the quantitative liquid sucking and discharging units 144 and the positive and negative pressure sources 148 of the same parameters in the first reagent unit 141 and the second reagent unit 142, accurate control of reagent transfer between the reagent units and the liquid sucking and discharging units is achieved; the consistency of reagent conveying paths for conveying reagents to the shared pipeline respectively in the whole sample detection process of the same sample preparation channel is effectively ensured; the channel consistency caused by the technical link that reagents are conveyed into a shared pipeline for premixing in the whole sample detection process of different sample preparation channels is effectively ensured.
Referring to fig. 5, fig. 5 is a schematic diagram of a second embodiment of the blood analyzer of the present application, and fig. 5 is a description based on fig. 1.
The blood analyzer further includes: the first liquid sucking and discharging unit 15, the fourth gate valve 16, the fifth gate valve 17 and the waste liquid discharging part 18, the first liquid sucking and discharging unit 15 is connected with the shared pipeline 12, the detection tank unit 11 and the waste liquid discharging part 18 through the fourth gate valve 16, and the first liquid sucking and discharging unit 15 is connected with the positive and negative pressure source 148 through the fifth gate valve 17.
The positive and negative pressure source 148 controls the internal pressure of the first liquid suction and discharge unit 15 through the fifth gate valve 17, and achieves the input and discharge of the front mixed-stage sample of the sample input into the shared line 12 to the first liquid suction and discharge unit 15, and the output of the sample remaining in the shared line 12, which is not input into the detection cell unit 11, from the first liquid suction and discharge unit 15 to the waste liquid discharge portion 18.
The first liquid sucking and discharging unit 15 is controlled to suck the sample of the conducted sample preparation channel preparation 14 into the shared pipeline 12, so that the sucked sample forms a tubular sample section, and the tubular sample section comprises a front mixing section positioned at the front head, a stable section connected behind the front mixing section and a rear mixing section positioned at the rear head. Wherein, before the sample of the stable section in the shared pipeline 12 is conveyed to the detection cell unit 11, the front mixed section in the shared pipeline 12 is further screened by the first liquid sucking and discharging unit 15, and after the sample of the stable section in the shared pipeline 12 is conveyed to the detection cell unit 11, the rear mixed section in the shared pipeline is screened by the first liquid sucking and discharging unit 15.
In the technical solution of the present application, unlike the prior art, the blood analyzer further includes: the first liquid sucking and discharging unit 15, the fourth gate valve 16, the fifth gate valve 17 and the waste liquid discharging part 18, the first liquid sucking and discharging unit 15 is connected with the shared pipeline 12, the detection tank unit 11 and the waste liquid discharging part 18 through the fourth gate valve 16, and the first liquid sucking and discharging unit 15 is connected with the positive and negative pressure source 148 through the fifth gate valve 17. In the above manner, the samples of the N sample preparation channels 14 can share one detection cell unit 11, the first liquid suction and discharge unit 15, and the waste liquid discharge portion 18, without providing a separate set of waste liquid treatment components for each sample preparation channel 14 to discharge the front section where contamination is likely or already present and the rear section where contamination is likely or already present, respectively; the channel consistency caused by the technical links of discarding the front and rear pollution sections in the shared pipeline in the whole sample detection process of different sample preparation channels is effectively ensured.
In some embodiments of the present application, the quantitative driving performance of the quantitative liquid sucking and discharging unit 144 in the first reagent unit 141 is different from the quantitative driving performance of the quantitative liquid sucking and discharging unit 144 in the second reagent unit 142 in the same sample preparation channel 14. Because of the difference of the types and the amounts of the reagents to be conveyed in the same sample preparation channel 14, different quantitative liquid sucking and discharging units 144 are configured to convey the corresponding reagents, the overall reagent conveying efficiency and the reagent conveying quality are effectively improved, and the detection efficiency of the whole machine is further improved.
The quantitative driving performance of the quantitative liquid sucking and discharging unit 144 includes liquid sucking time and liquid discharging time. For example, the reagent in the first reagent unit 141 includes a dye solution, and the reagent in the second reagent unit 142 includes a diluent or a hemolyzing agent, and since the dye solution is used in an amount smaller than the diluent or the hemolyzing agent, the pipetting time and the draining time of the first reagent unit 141 are smaller than those of the second reagent unit 142. In another embodiment, in order to reduce contamination caused by diffusion of the first reagent (e.g., dye liquor), the pipetting time and the drain time of the first reagent unit 141 are greater than those of the second reagent unit 142.
The quantitative driving performance of the quantitative liquid sucking and discharging unit 144 further includes the specification of the positive and negative pressure source 148 connected to the quantitative liquid sucking and discharging unit 144, the specification of the connected reagent accommodating unit 145, and the specification of the pipe connected to the reaction tank unit 143. For example, the reagent in the first reagent unit 141 includes a dye solution, the reagent in the second reagent unit 142 includes a diluent or a hemolyzing agent, since the dye solution is used in an amount smaller than the diluent or the hemolyzing agent, the difference between the positive and negative pressure sources 148 connected to the first reagent unit 141 may be smaller than the difference between the positive and negative pressure sources 148 connected to the second reagent unit 142, the capacity of the reagent receiving unit 145 connected to the first reagent unit 141 may be smaller than the capacity of the reagent receiving unit 145 connected to the second reagent unit 142, the pipe length and pipe diameter of the pipe connected to the first reagent unit 141 and the reaction tank unit 143 may be smaller than the pipe length and pipe diameter of the pipe connected to the second reagent unit 142 and the reaction tank unit 143, and the material of the pipe connected to the first reagent unit 141 and the reaction tank unit 143 may be different from the material of the pipe connected to the second reagent unit 142 and the reaction tank unit 143.
When the quantitative liquid sucking and discharging unit 144 is a quantitative pump, the quantitative driving performance of the quantitative liquid sucking and discharging unit 144 further includes: the internal volume of the pump, the motor parameters (such as rotation speed, current, capacitance, etc.) for controlling the pump, the air pressure parameters (such as the air pressure during sucking and discharging liquid), etc. Illustratively, the internal volume of the dosing pump in the first reagent unit 141 is less than the internal volume of the dosing pump in the second reagent unit 142. And/or, in different sample preparation channels 14, the opening and closing performance of the second gate valves 146 in all the first reagent units 141 is the same, meaning that when the second gate valves 146 in all the first reagent units 141 are in the conducting state, the flow rate and/or valve configuration and/or valve function and/or valve chamber content and/or valve pattern of the corresponding sample passing through the second gate valves 146 are the same; when the second gate valves 146 in all the first reagent units 141 are in the blocked state, the flow rate and/or valve configuration and/or valve function and/or valve chamber volume and/or valve pattern of the corresponding sample through the second gate valve 146 is the same.
In blood detection, the measurement consistency of the samples of different sample preparation channels 14 is required to be higher, and the opening and closing performances of the second gate valves 146 in all the first reagent units 141 are the same, so that the channel consistency of the process of injecting the reagents of the first reagent units 141 into the reaction tank unit in the whole sample detection process of different sample preparation channels 14 can be effectively improved, the channel consistency of the process of carrying out reagent premixing in the shared pipeline in the whole sample detection process of different subsequent sample preparation channels 14 can be effectively improved, and the accuracy of blood detection results can be further improved.
And/or, in different sample preparation channels 14, the opening and closing performance of the third gate valves 147 in all the first reagent units 141 are the same, which means that when the third gate valves 147 in all the first reagent units 141 are in the conducting state, the pressures and/or valve configurations and/or valve functions and/or valve chamber content and/or valve patterns generated by the corresponding positive and negative pressure sources 148 are the same.
By making the opening and closing performances of the third gate valves 147 in all the first reagent units 141 of the different sample preparation channels 14 the same, it can be ensured that the pressures generated by the positive and negative pressure sources 148 corresponding to the different sample preparation channels 14 are the same, the channel consistency of the suction and discharge reagent links of the first reagent units 141 of the different sample preparation channels 14 in the whole sample detection process is effectively improved, the channel consistency of the reagent injection of the first reagent units 141 of the different sample preparation channels 14 in the whole sample detection process to the reaction tank unit links is effectively improved, and the accuracy of the blood detection result is further improved.
Different sample preparation channels 14 are connected with the same detection cell unit 11 through the shared pipeline 12, and the measurement consistency of the reagents of the first reagent units 141 in different sample preparation channels 14 is further ensured by ensuring that the opening and closing performances of all second gating valves 146 in the first reagent units 141 in different sample preparation channels 14 are the same or the opening and closing performances of the third gating valves 147 are the same.
And/or, in different sample preparation channels 14, the opening and closing performance of the second gate valves 146 in all the second reagent units 142 is the same, meaning that when the second gate valves 146 in all the second reagent units 142 are in the conducting state, the flow rate and/or valve configuration and/or valve function and/or valve chamber content and/or valve pattern of the corresponding sample passing through the second gate valve 146 is the same; when the second gate valves 146 in all the first reagent units 141 are in the blocked state, the flow rate and/or valve configuration and/or valve function and/or valve chamber volume and/or valve pattern of the corresponding sample through the second gate valve 146 is the same.
In blood detection, the measurement consistency of the samples of different sample preparation channels 14 is required to be higher, and the opening and closing performances of the second gate valves 146 in all the second reagent units 142 are the same, so that the channel consistency of the reagent injection of the second reagent units 142 to the reaction tank unit link in the whole sample detection process of different sample preparation channels 14 can be effectively improved, the channel consistency of the reagent premixing link of the shared pipeline of the following different sample preparation channels 14 in the whole sample detection process can be effectively improved, and the accuracy of the blood detection result is further improved.
And/or, in different sample preparation channels 14, the opening and closing performance of the third gate valves 147 in all the second reagent units 142 is the same, which means that when the third gate valves 147 in all the second reagent units 142 are in the conducting state, the air pressure and/or the valve configuration and/or the valve function and/or the valve chamber content and/or the valve pattern generated by the corresponding positive and negative pressure sources 148 are the same.
By making the opening and closing performance of the third gate valves 147 in all the second reagent units 142 of the different sample preparation channels 14 the same, it can be ensured that the pressures generated by the positive and negative pressure sources 148 corresponding to the different sample preparation channels 14 are the same, so that the channel consistency of the suction and discharge reagent links of the second reagent units 142 of the different sample preparation channels 14 in the whole sample detection process is effectively improved, the channel consistency of the reagent injection of the first reagent units 141 of the different sample preparation channels 14 in the whole sample detection process to the reaction tank unit links is effectively improved, and the accuracy of the blood detection result is further improved.
And/or, in different sample preparation channels 14, the quantitative driving performance of the quantitative liquid sucking and discharging units 144 in all the first reagent units 141 is the same, which means that the liquid sucking time, the liquid discharging time, the specification of the positive and negative pressure sources 148 connected to the quantitative liquid sucking and discharging units 144, the specification of the connected reagent containing units 145, and the specification of the pipes connected to the reaction tank units 143 in all the first reagent units 141 are the same.
In the blood test, the measurement consistency of the samples of different sample preparation channels 14 is required to be higher, and the channel consistency of the quantitative liquid sucking and discharging units 144 of the first reagent units 141 sucking/discharging reagent links of different sample preparation channels 14 in the whole test process can be effectively improved by making the quantitative driving performances of the quantitative liquid sucking and discharging units 144 in all the first reagent units 141 the same, so that the accuracy of the blood test result is improved.
And/or, in different sample preparation channels 14, the quantitative driving performance of the quantitative liquid sucking and discharging units 144 in all the second reagent units 142 is the same, which means that the liquid sucking time, the liquid discharging time, the specification of the positive and negative pressure sources 148 connected to the quantitative liquid sucking and discharging units 144, the specification of the connected reagent containing units 145, and the specification of the pipes connected to the reaction tank units 143 in all the second reagent units 142 are the same.
In some embodiments, there is a case where the actual liquid suction amount and the liquid discharge amount of the quantitative liquid suction and discharge units 144 of all the first reagent units 141 or the second reagent units 142 in the different sample preparation channels 14 are not completely accurate due to errors in the control (e.g., the liquid suction time and the liquid discharge time) of each of the first reagent units 141 and/or the second reagent units 142 in the different sample preparation channels 14, and when the difference between the actual liquid suction amount and the liquid discharge amount of the quantitative liquid suction and discharge units 144 of all the first reagent units 141 in the different sample preparation channels 14 is within a certain error range, it is also considered that the quantitative driving performance of the quantitative liquid suction and discharge units 144 in the first reagent units 141 or the second reagent units 142 in the different sample preparation channels 14 is the same.
In other embodiments, the presence of certain errors in at least one of the specifications of the positive and negative pressure sources 148, the specifications of the connected reagent receiving units 145, and the specifications of the tubes connected to the reaction cell units 143, which are respectively connected to the quantitative liquid sucking and discharging units 144 of all the first reagent units 141 or the second reagent units 142 in the different sample preparation channels 14, due to assembly errors, may cause the actual liquid sucking and discharging amounts to be not completely accurate, and may be considered to be substantially the same when the errors are within certain errors, i.e., the calibrated, and may also be considered to be the same for the quantitative driving performance of the quantitative liquid sucking and discharging units 144 in the first reagent units 141 or the second reagent units 142 in the different sample preparation channels 14.
In still other embodiments, when the quantitative liquid sucking and discharging unit 144 is a quantitative pump, there is a certain error in at least one of the internal volume of the pump, the motor parameter (such as rotation speed, current, capacitance, etc.) of the control pump, and the air pressure parameter (such as air pressure at the time of sucking and discharging) of the quantitative liquid sucking and discharging unit 144 of all the first reagent units 141 or the second reagent units 142 in the different sample preparation channels 14, respectively, due to assembly and calibration errors, resulting in the fact that the actual liquid sucking and discharging amounts of the quantitative liquid sucking and discharging units 144 of all the first reagent units 141 or the second reagent units 142 in the different sample preparation channels 14 are not completely accurate, and when the error is within a certain error range, it is also considered that the quantitative driving performance of the quantitative liquid sucking and discharging units 144 in the first reagent units 141 or the second reagent units 142 in the different sample preparation channels 14 is the same.
In the blood test, the measurement consistency of the samples of different sample preparation channels 14 is required to be higher, and the channel consistency of the reagent sucking/discharging links of the quantitative sucking/discharging units 144 of the second reagent units 142 in the whole test process of different sample preparation channels 14 can be effectively improved by making the quantitative driving performance of the quantitative sucking/discharging units 144 of all the second reagent units 142 the same, so that the accuracy of the blood test result is improved.
In the technical scheme of the application, compared with the prior art, in the same sample preparation channel 14, the quantitative driving performance of the quantitative liquid sucking and discharging unit 144 in the first reagent unit 141 is different from the quantitative driving performance of the quantitative liquid sucking and discharging unit 144 in the second reagent unit 142, so that the requirements of sample preparation links on different reagent types and required reagent amounts can be met, and the effect of accurately quantifying the reagents is achieved; simultaneously, the parameter performance of at least one component in all the first reagent units 141 or all the second reagent units 142 in different sample preparation channels 14 is the same; the channel consistency of the quantitative liquid sucking and discharging units of the first reagent unit 141 and the second reagent unit 142 in the corresponding reagent sucking/discharging links of different sample preparation channels 14 in the whole sample detection process can be effectively improved.
Referring to fig. 6, fig. 6 is a schematic diagram of a frame of a second embodiment of the first reagent unit 141 or the second reagent unit 142 of the present application, and fig. 6 is a description based on fig. 4.
The first reagent unit 141 and the second reagent unit 142 each include a reagent suction pipe 1451 and a reagent supply pipe 1441, and the reagent accommodating unit 145 is connected to the quantitative liquid suction/discharge unit 144 through the reagent suction pipe 1451, and the quantitative liquid suction/discharge unit 144 is connected to the reaction cell unit 143 through the reagent supply pipe 1441.
The first characteristic parameters of the reagent suction pipes 1451 of all the first reagent units 141 are the same, and the first characteristic parameters of the reagent suction pipes 1451 of the first reagent units 141 include, but are not limited to, the length, pipe diameter, material properties, or type of joint connected between the reagent suction pipes 1451. For the reagents of the same type, such as diluent or hemolytic agent with large dosage and/or low cost carried by the first reagent unit 141, the characteristic parameters of the reagent suction pipes 1451 of the first reagent units 141 respectively corresponding to the different sample preparation channels 14 are kept consistent, so that the channel consistency of the corresponding reagent links sucked by the quantitative suction and discharge units in the whole sample preparation process of the different sample preparation channels 14 can be effectively improved, and the accuracy of the sample detection result is further improved; and is helpful for the management and maintenance of the whole machine.
And/or, the second characteristic parameters of the reagent supply lines 1441 of all the first reagent units 141 are the same, and the second characteristic parameters of the reagent supply lines 1441 of the first reagent units 141 may be the length, the pipe diameter, the material characteristics, or the type of joint connected between the lines of the reagent supply lines 1441. For the reagents of the same type, such as diluent or hemolytic agent with large dosage and/or low cost carried by the first reagent unit 141, the reagent supply pipes 1441 of the first reagent units 141 respectively corresponding to the different sample preparation channels 14 keep the characteristic parameters consistent, so that the channel consistency of the quantitative liquid sucking and discharging units injected into the corresponding reagent links in the whole sample preparation process of the different sample preparation channels 14 can be effectively improved, and the accuracy of the sample detection result is further improved; and is helpful for the management and maintenance of the whole machine.
And/or, the third characteristic parameters of the reagent suction pipes 1451 of all the second reagent units 142 are the same, and the third characteristic parameters of the reagent suction pipes 1451 of the second reagent units 142 may be the length, the pipe diameter, the material property, or the type of joint connected between the pipes of the reagent suction pipes 1451. Aiming at the same type of reagent, such as a small-dosage and/or high-cost dye borne by the second reagent unit 142, the reagent suction pipes 1451 of the second reagent units 142 respectively corresponding to different sample preparation channels 14 keep the characteristic parameters consistent, so that the channel consistency of the corresponding reagent links sucked by the quantitative suction and discharge units in the whole sample preparation process of different sample preparation channels 14 can be effectively improved, and the accuracy of the sample detection result is further improved; and is helpful for the management and maintenance of the whole machine.
And/or, the fourth characteristic parameter of the reagent supply lines 1441 of all the second reagent units 142 is the same, and the fourth characteristic parameter of the reagent supply lines 1441 of the second reagent units 142 may be the length, the pipe diameter, the material property, or the type of joint connected between the lines of the reagent supply lines 1441. Aiming at the same type of reagent, such as a small-dosage and/or high-cost dye borne by the second reagent unit 142, the reagent supply pipes 1441 of the second reagent units 142 respectively corresponding to different sample preparation channels 14 keep the characteristic parameters consistent, so that the consistency of the channels of the corresponding reagent links sucked by the quantitative suction and discharge units in the whole sample preparation process of different sample preparation channels 14 can be effectively improved, and the accuracy of the sample detection result is further improved; and is helpful for the management and maintenance of the whole machine.
And/or, in the same sample preparation channel 14, at least one first characteristic subparameter of the first characteristic parameters of the reagent suction tube 1451 of the first reagent unit 141 is different from at least one third characteristic subparameter of the third characteristic parameters of the reagent suction tube 1451 of the second reagent unit 142, which means that at least one of the length, the tube diameter, the material property, or the type of joint connected between the tubes of the reagent suction tube 1451 of the first reagent unit 141 is different from the length, the tube diameter, the material property, or the type of joint connected between the tubes of the reagent suction tube 1451 of the second reagent unit 142.
And/or, in the same sample preparation channel 14, at least one second characteristic subparameter of the second characteristic parameters of the reagent supply tube 1441 of the first reagent unit 141 is different from at least one fourth characteristic subparameter of the fourth characteristic parameters of the reagent supply tube 1441 of the second reagent unit 142, meaning that at least one of the length, the tube diameter, the material property, or the type of joint connected between the tubes of the reagent supply tube 1441 of the first reagent unit 141 is different from the length, the tube diameter, the material property, or the type of joint connected between the tubes of the reagent supply tube 1441 of the second reagent unit 142.
For different types of reagents, such as diluent or hemolytic agent with large dosage and/or low cost carried by the first reagent unit 141, a reagent supply pipe 1441 with large inlet caliber and/or large pipe diameter is correspondingly arranged so as to reduce pipe resistance and facilitate faster transportation of the required amount of reagent, thereby improving the efficiency of mixing the reagent and the sample and further improving the overall reaction efficiency of the blood analyzer; the small-usage and/or high-cost dye carried by the second reagent unit 142 is correspondingly provided with a reagent supply pipe 1441 with a small inlet caliber and/or a small pipe diameter so as to prevent diffusion, and the small inlet caliber of the pipeline and/or the small pipe diameter of the pipeline are beneficial to reducing the situation that liquid in a part connected with the pipeline diffuses into the pipeline to pollute the reagent in the pipeline, so that the problem that reagent consumption is high due to large reagent diffusion among the pipelines is solved; in the transportation process of the reagent, reagent residues can be generated at the positions of transported pipelines, parts and the like, and the lengths of the pipelines are short so as to reduce the loss and the waste in the transportation process of the reagent.
In contrast to the prior art, in the solution of the present application, in the same sample preparation channel 14, at least one second characteristic sub-parameter of the second characteristic parameters of the reagent supply line 1441 of the first reagent unit 141 is different from at least one third characteristic sub-parameter of the reagent suction line 1451 of the second reagent unit 142 and/or at least one second characteristic sub-parameter of the first characteristic parameters of the reagent supply line 1441 of the first reagent unit 141 is different from at least one fourth characteristic sub-parameter of the reagent supply line 1441 of the second reagent unit 142 by ensuring that the at least one first characteristic sub-parameter is different from the at least one third characteristic sub-parameter of the first characteristic parameters of the reagent suction line 1451 of the first reagent unit 141. Based on the above manner, the reagent suction tube 1451 and the reagent supply tube 1441 with corresponding parameters can be set according to different costs and materials of the reagents of the first reagent unit 141 and the reagents of the second reagent unit 142, so as to meet the requirements of different reagent types and required amounts in the sample preparation process, and help to improve the detection efficiency of the whole machine.
In some embodiments of the present application, the second gate valve 146 and the third gate valve 147 in the first reagent unit 141 have the same electrical parameters in the same sample preparation channel 14. The electrical parameters of the gate valve may include parameters such as response time at a certain voltage, rated voltage, allowable voltage variation range, power consumption at rated voltage, operational noise, etc.
And/or the second gating valve 146 in the second reagent unit 142 and the third gating valve 147 have the same electrical parameters in the same sample preparation channel 14. Based on the above manner, in the same sample preparation channel 14, by setting the second gate valve 146 and the third gate valve 147 with the same two electrical parameters, the stability and consistency of the liquid path control between the corresponding reaction tank unit 143 and the shared pipeline 12 are realized, so that the sample preparation channel 14 is convenient to manage and maintain. The electrical parameters of the first reagent unit 141 and/or the second gate valve 146 in the second reagent unit 142 and the third gate valve 147 in the same sample preparation channel are the same, so that the consistency of different reagent conveying links in the whole sample detection process of the same sample preparation channel is further ensured.
And/or, in different sample preparation channels 14, the electrical parameters of the second gate valves 146 in all of the first reagent units 141 are the same. Based on the above manner, in different sample preparation channels 14, the second gate valve 146 with the same electrical parameter is set in each first reagent unit 141, so that the stability and consistency of the liquid path control between each first reagent unit 141 and the corresponding reaction cell unit 143 are realized, and the channel consistency of the first reagent conveying links in the whole sample detection process of different sample preparation channels is further ensured.
And/or, in different sample preparation channels 14, the electrical parameters of the third gate valves 147 in all of the first reagent units 141 are the same. Based on the above manner, in the different sample preparation channels 14, the third gate valve 147 with the same electrical parameter is set in each first reagent unit 141, so that the smoothness and consistency of the liquid path control between each first reagent unit 141 and the corresponding reaction cell unit 143 are realized, and the channel consistency of the first reagent conveying links in the whole sample detection process of the different sample preparation channels is further ensured.
And/or, in different sample preparation channels 14, the electrical parameters of the second gate valves 146 in all of the second reagent units 142 are the same. Based on the above manner, in different sample preparation channels 14, the second gate valves 146 with the same electrical parameters are arranged in each second reagent unit 142, so that the stability and consistency of the liquid path control between each second reagent unit 142 and the corresponding reaction cell unit 143 are realized, and the channel consistency of the second reagent conveying links in the whole sample detection process of different sample preparation channels is further ensured.
And/or, in different sample preparation channels 14, the electrical parameters of the third gate valves 147 in all of the second reagent units 142 are the same. In this way, in the different sample preparation channels 14, the third gate valve 147 with the same electrical parameter is set in each second reagent unit 142, so that the stability and consistency of the liquid path control between each second reagent unit 142 and the corresponding reaction cell unit 143 are realized, and the channel consistency of the second reagent conveying links in the whole sample detection process of the different sample preparation channels is further ensured.
And/or the fourth gate valve 16 of the first liquid suction and discharge unit 15 is identical to the fifth gate valve 17 in electrical parameter. Based on the above mode, through setting up the fourth gate valve 16 and the fifth gate valve 17 of two same electrical parameters, realize the stationarity and the uniformity of liquid circuit control between first inhale and expel unit 15 and the shared pipeline 12, in whole sample testing process, guarantee that first inhale and expel unit carries out the uniformity of imbibition and flowing back link.
And/or the fourth gate valve 16 of the first pipetting unit 15 has the same electrical parameters as the at least one second gate valve 146 in the N sample preparation channels 14. Based on the above manner, by setting the electrical parameters of the fourth gate valve 16 of the first liquid sucking and discharging unit 15 to be the same as the electrical parameters of the second gate valve 146 of the at least one first reagent unit 141, the consistency and stability of the liquid path transmission between the first liquid sucking and discharging unit 15 and the shared pipeline 12 and the consistency of the liquid path transmission between the at least one first reagent unit 141 and the shared pipeline 12 are realized, and in the whole sample detection process, the consistency of the liquid sucking and discharging links of the first liquid sucking and discharging unit and the first reagent unit is ensured; or through setting up the electrical parameter of the fourth gate valve 16 of the first liquid sucking and discharging unit 15 and the electrical parameter of the second gate valve 146 of the at least one second reagent unit 142 the same, realize the uniformity and stability of the liquid path transmission between the first liquid sucking and discharging unit 15 and the shared pipeline 12 and the liquid path transmission between the at least one second reagent unit 142 and the shared pipeline 12, in the whole sample detection process, ensure the uniformity of the liquid sucking and discharging links of the liquid sucking and discharging unit and the second reagent unit by the first liquid sucking and discharging unit, and then can obtain the blood detection result with higher accuracy when the different sample preparation channels 14 are matched with one first liquid sucking and discharging unit 15 together for blood detection.
And/or the fifth gate valve 17 of the first pipetting unit 15 has the same electrical parameters as the at least one third gate valve 147 in the N sample preparation channels 14. Based on the above manner, by setting the electrical parameters of the fifth gate valve 17 of the first liquid sucking and discharging unit 15 to be the same as the electrical parameters of the third gate valve 147 of the at least one first reagent unit 141, the consistency and stability of the liquid path transmission between the first liquid sucking and discharging unit 15 and the shared pipeline 12 and the liquid path transmission between the at least one first reagent unit 141 and the shared pipeline 12 are realized, and in the whole sample detection process, the consistency of the liquid sucking and discharging links of the first liquid sucking and discharging unit and the first reagent unit is ensured; or by setting the electrical parameters of the fifth gate valve 17 of the first liquid sucking and discharging unit 15 to be the same as the electrical parameters of the third gate valve 147 of the at least one second reagent unit 142, the consistency and stability of the liquid path transmission between the first liquid sucking and discharging unit 15 and the shared pipeline 12 and the liquid path transmission between the at least one second reagent unit 142 and the shared pipeline 12 are realized, and in the whole sample detection process, the consistency of the liquid sucking and discharging links of the second liquid sucking and discharging unit and the first reagent unit is ensured, so that the blood detection result with higher accuracy can be obtained when different sample preparation channels 14 are matched with one first liquid sucking and discharging unit 15 together for blood detection.
And/or, in different sample preparation channels 14, the electrical interfaces of the N first gate valves 13 are connected with the same circuit board, and each first gate valve 13 is driven by a MOS transistor or triode with the same electrical parameter. Based on the above manner, in different sample preparation channels 14, through connecting the electrical interfaces of the N first gate valves 13 with the same circuit board, and driving each first gate valve 13 by a MOS tube or a triode with the same electrical parameters, the consistency of current driving of each first gate valve 13 is realized, and further, the consistency of opening and closing performance of the N first gate valves 13 is realized, and further, the channel consistency of the liquid path transmission link of the N sample preparation channels 14 through the N first gate valves 13 is realized.
And/or, in different sample preparation channels 14, the electrical interfaces of the N second gate valves 146 are connected to the same circuit board, and each second gate valve 146 is driven by a MOS transistor or triode having the same electrical parameter. Based on the above manner, in different sample preparation channels 14, by connecting the electrical interfaces of the N second gate valves 146 with the same circuit board, and driving each second gate valve 146 by a MOS transistor or triode with the same electrical parameters, the consistency of the current driving of each second gate valve 146 is achieved, and further, the consistency of the opening and closing performance of the N second gate valves 146 is achieved, and further, the channel consistency of the liquid path transmission link of the N sample preparation channels 14 through the N second gate valves 146 is achieved.
And/or, in different sample preparation channels 14, the electrical interfaces of the N third gate valves 147 are connected to the same circuit board, and each third gate valve 147 is driven by a MOS transistor or triode having the same electrical parameter. Based on the above manner, in different sample preparation channels 14, by connecting the electrical interfaces of the N third gate valves 147 with the same circuit board, and driving each third gate valve 147 by a MOS transistor or triode with the same electrical parameters, the consistency of current driving of each third gate valve 147 is achieved, and further, the consistency of opening and closing performance of the N third gate valves 147 is achieved, and further, the channel consistency of the liquid path transmission link of the N sample preparation channels 14 through the N third gate valves 147 is achieved.
Optionally, on the same circuit board, a plurality of MOS tubes or triodes are arranged side by side, so that the line distance from each MOS tube or triode to a circuit interface is consistent, the plurality of MOS tubes or triodes are ensured to have the same electrical parameters, and the accuracy and consistency of the response time of driving each MOS tube or triode are further ensured.
In some embodiments, due to errors in control, assembly, calibration, etc., the response time of the second gate valve, the third gate valve, and the fifth gate valve at a certain voltage, the rated voltage, the allowable voltage variation range, the consumed power at the rated voltage, and the action noise of the gate valves are not identical due to errors, and when the errors are within a certain error range, the electrical parameters of the corresponding gate valves in the above schemes are also considered to be identical.
In the technical scheme of the application, different sample preparation channels 14 are connected with the same detection cell unit 11 through a shared pipeline 12, and N first gating valves 13 in the different sample preparation channels 14 are connected with the same circuit board, and N first gating valves 13 are driven by N identical MOS tubes or triodes; the N second gate valves 146 are connected to the same circuit board, and the N second gate valves 146 are driven by N identical MOS transistors or triodes; the N third gate valves 147 are connected to the same circuit board, and the N third gate valves 147 are driven by N identical MOS transistors or triodes. Based on the above manner, through the fact that the electrical parameters of the N first gate valves 13, the N second gate valves 146 and/or the N third gate valves 147 in different sample preparation channels 14 are identical, and through ensuring that the N first gate valves 13 in different sample preparation channels 14 are connected with the same circuit board, and the N first gate valves 13 are driven by N identical MOS transistors or triodes, the consistency of current driving of each third gate valve 147 is realized, the consistency of opening and closing performance of the N third gate valves 147 is further realized, the consistency of opening and closing performance of the N first gate valves 13, the N second gate valves 146 and/or the N third gate valves 147 is further realized, and the consistency of measurement of liquid path transmission of the samples in the first reagent unit 141 and the samples in the second reagent unit 142 through the gate valves is further realized.
Referring to fig. 7, fig. 7 is a schematic diagram of a third embodiment of the blood analyzer of the present application, and fig. 7 is a description based on fig. 5.
In the present embodiment, the blood analyzer further includes a control unit (not shown), a drive unit 20, and a purge unit 21, the drive unit 20 being connected to the detection cell unit 11 through the shared line 12, and the purge unit 21 being connected to the detection cell unit 11 through the shared line 12 and the drive unit 20.
The control unit is used for: when only one of the first gate valves 13 is turned on, the sample preparation channel 14 corresponding to the first gate valve 13 in the turned-on state is subjected to sample transport by the driving action of the driving unit 20 or the sample preparation channel 14 corresponding to the first gate valve 13 in the turned-on state is cleaned at least by the cleaning unit 21.
Specifically, when only one of the first gate valves 13 is turned on, only the corresponding one of the sample preparation channels 14 is turned on through the shared pipeline 12 and the detection cell unit 11, and the sample is transported under the driving action of the driving unit 20, that is, the sample in the sample preparation channel 14 corresponding to the first gate valve 13 that is turned on only is transported to the shared pipeline 12 through the first gate valve 13 that is turned on only, and then, the part of the sample located in the shared pipeline 12 at this time is transported to the detection cell unit 11 through the driving unit 20. In another embodiment, the sample preparation channel 14 corresponding to the first gate valve 13 in the on state is cleaned at least by the cleaning unit 21, the cleaning unit 21 may include a container bottle or a container bag containing a cleaning agent, the cleaning agent may include a hemolysis agent or a dilution liquid, the cleaning agent in the cleaning unit 21 cleans the shared line 12 by the driving action of the driving unit 20, the cleaning agent in the cleaning unit 21 backflushes the sample preparation channel 14 corresponding to the first gate valve 13 which is uniquely turned on by the driving action of the driving unit 20 and backflushes the sample preparation channel 14, and the cleaning agent in the cleaning unit 21 backflushes the detection cell unit 11 by the driving action of the driving unit 20 and backflushes the detection cell unit 11, and the waste liquid after cleaning may be output at least by the waste liquid discharge portion 18.
In the technical scheme of the application, the N sample preparation channels 14 can share one set of control unit and driving unit 20 to drive the transportation of samples from different sample preparation channels 14 in the shared pipeline 12, so that the consistency of the transportation of the samples of the different sample preparation channels 14 is effectively improved, and the consistency of the inspection parameters among different detection channels is further improved. The N sample preparation channels 14 can share a set of control unit and cleaning unit 21, and when a single sample preparation channel is cleaned, the cleaning force of the single sample preparation channel is increased and the cleaning effect is enhanced by the recoil force applied by the cleaning unit 21.
In some embodiments of the present application, the sample preparation channel 14 further comprises a waste cell unit directly connected to the reaction cell unit 143, the waste cell unit being used for directly washing the corresponding reaction cell unit 143. In some embodiments, the cleaning effect of the single sample preparation channel 14 is effectively enhanced by the direct cleaning of the reaction cell unit 143 by the waste cell unit and the back-flushing of the cleaning unit 21.
Alternatively, in some embodiments of the present application, when only one of the first gate valves 13 is turned on and the sample preparation channel 14 corresponding to the first gate valve 13 in the turned-on state is washed at least by the washing unit 21, the washing liquid of the washing unit 21 flows to the sample preparation channel 14 through the shared line 12 and the turned-on first gate valve 13. In this embodiment, when the shared pipeline 12 and the sample preparation channel 14 need to be cleaned, the cleaning solution of the cleaning unit 21 flows to the sample preparation channel 14 through the shared pipeline 12 and the first gate valve 13, so as to clean the shared pipeline 12 and the sample preparation channel 14, and when the sample preparation channel 14 is cleaned, the first gate valve 13 does not convey the sample.
In other embodiments of the present application, when all N first gate valves are completely blocked, the shared pipeline 12 and/or the detection cell unit 11 is cleaned by the cleaning unit 21, and at this time, all the sample preparation channels 14 and the shared pipeline 12 are not conducted, so that the cleaning effect on the shared pipeline 12 and/or the detection cell unit 11 is effectively enhanced.
In this embodiment, the same driving unit 20 is used for transporting or cleaning the samples in the different sample preparation channels 14, so that the development cost of the blood analyzer can be effectively reduced, and the complexity of the supply chain can be reduced.
Referring to fig. 8, fig. 8 is a schematic view of the first embodiment of the reactor unit of the present application.
In this embodiment, the reaction cell units 143 corresponding to at least two sample preparation channels 14 are assembled and connected in a multi-well format. A multi-tank formed by assembling two reaction tank units 143, wherein the side wall of one reaction tank unit 143 is shared with the side wall of the other reaction tank; n (N is more than 2) reaction tank units 143 are serially assembled into a multi-connected tank, two opposite side walls of the middle (N-2) reaction tanks are respectively shared with one side wall of the adjacent reaction tank, and 2 reaction tanks at the edge are shared with the adjacent reaction tank close to the side wall of the multi-connected tank.
In some embodiments of the present application, the sample preparation channel 14 further includes a preheating part and a cleaning liquid supply unit, the cleaning liquid supply unit being connected to the reaction tank unit 143, the preheating part being configured to heat the reagent supplied by the first reagent unit 141 and/or to heat the reagent supplied by the second reagent unit 142 and/or to heat the cleaning liquid supplied by the cleaning liquid supply unit, i.e., the preheating part being configured to heat at least one of the reagent supplied by the first reagent unit 141, the reagent supplied by the second reagent unit 142 and the cleaning liquid supplied by the cleaning liquid supply unit. Alternatively, when the amount of the reagent supplied from the first reagent unit 141 is small, for example, the reagent supplied from the first reagent unit 141 is dye solution, the preheating part is not used for heating to reduce the consumption of the preheating part, and when the sample preparation is performed by mixing the first reagent, the second reagent and the sample, the preheating part is used for heating the second reagent with larger amount, and when the heated second reagent is mixed with the unheated first reagent with smaller amount, the first reagent is still in error range due to smaller amount, the heat exchange loss between the reagents is smaller, the temperature of the mixed sample is not affected, and the power consumption is reduced.
In this embodiment, the reaction cell units 143 corresponding to at least two sample preparation channels 14 are assembled and connected in a multi-well format. A multi-tank formed by assembling two reaction tank units 143, wherein the side wall of one reaction tank unit 143 is shared with the side wall of the other reaction tank; n (N is more than 2) reaction tank units 143 are serially assembled into a multi-connected tank, two opposite side walls of the middle (N-2) reaction tanks are respectively shared with one side wall of the adjacent reaction tank, and 2 reaction tanks at the edge are shared with the adjacent reaction tank close to the side wall of the multi-connected tank.
In the technical solution of the present application, the sample preparation channel 14 further includes a preheating part and a cleaning liquid supply unit, which is connected to the reaction cell unit 143, unlike the related art. Based on the above mode, the preheating part is arranged to heat the reagent and/or the cleaning liquid which are to enter the reaction tank, so that the mixture of the reagent and the sample is more uniform, or the cleaning effect of the cleaning liquid is better.
In the description of the present application, a description referring to terms "one embodiment," "some embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present application. In this specification, schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the different embodiments or examples described in this specification and the features of the different embodiments or examples may be combined and combined by those skilled in the art without contradiction.
Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In the description of the present application, the meaning of "plurality" is at least two, such as two, three, etc., unless explicitly defined otherwise.
The foregoing is only the embodiments of the present application, and not the patent scope of the present application is limited by the foregoing description, but all equivalent structures or equivalent processes using the contents of the present application and the accompanying drawings, or directly or indirectly applied to other related technical fields, which are included in the patent protection scope of the present application.

Claims (10)

1. A blood analyzer, characterized in that,
the blood analyzer comprises a detection pool unit, a shared pipeline, N first gating valves and N sample preparation channels, wherein N is not less than 2 and is an integer, and the N first gating valves are in one-to-one correspondence with the N sample preparation channels;
the sample preparation channel is used for preparing different samples;
each first gating valve is used for switching a conduction state and a blocking state between the corresponding sample preparation channel and the shared pipeline, and each first gating valve is correspondingly connected in series between one sample preparation channel and the shared pipeline;
The shared pipeline is used for receiving the samples prepared by the N sample preparation channels in a time-sharing mode and conveying the corresponding samples to the detection cell unit;
the detection pool unit is respectively connected with N sample preparation channels through the shared pipeline and is used for allowing samples provided by the shared pipeline to pass through so as to detect the samples;
wherein,,
the opening and closing performances of the N first gate valves are the same,
and in the on state of the blood analyzer,
all states of the N first gate valves include only two types: all N first gate valves are fully blocked and only one of the first gate valves is on.
2. The blood analyzer of claim 1, wherein the blood analyzer comprises a blood analyzer,
the sample preparation channel comprises a first reagent unit, a second reagent unit and a reaction tank unit;
the reaction tank unit is respectively connected with the first reagent unit and the second reagent unit, and is connected with the shared pipeline through the first gating valve;
the first reagent unit and the second reagent unit are used for supplying corresponding reagents to the reaction tank unit, and the reaction tank unit is used for receiving the reagents respectively supplied by the first reagent unit and the second reagent unit and receiving a sample so as to mix the received reagents with the sample to form the sample;
Wherein, in the reaction tank unit, the inlet caliber connected with the first reagent unit is different from the inlet caliber connected with the second reagent unit,
and/or the pipe diameter of the first reagent unit connected with the reaction tank unit is different from the pipe diameter of the second reagent unit connected with the reaction tank unit,
and/or the tube length of the first reagent unit connected with the reaction tank unit is different from the tube length of the second reagent unit connected with the reaction tank unit.
3. A blood analyzer according to claim 2, wherein,
the first reagent unit and the second reagent unit comprise a quantitative liquid sucking and discharging unit, a reagent accommodating unit, a second gating valve and a third gating valve, and the blood analyzer further comprises a positive pressure source and a negative pressure source;
the second gating valve is respectively connected with the quantitative liquid sucking and discharging unit, the reagent accommodating unit and the reaction tank unit, and when the second gating valve is in a first state, the quantitative liquid sucking and discharging unit is used for sucking corresponding reagent from the reagent accommodating unit; when the second gating valve is in a second state, the quantitative liquid sucking and discharging unit injects the sucked reagent into the reaction tank unit;
The quantitative liquid sucking and discharging unit is connected with the positive and negative pressure sources through the third gating valve
Wherein the amount of the reagent sucked from the reagent accommodating unit by the quantitative liquid sucking and discharging unit when the second gate valve is in the first state is equal to the amount of the reagent injected into the reaction tank unit by the quantitative liquid sucking and discharging unit when the second gate valve is in the second state,
the blood analyzer further comprises: the first liquid sucking and discharging unit is connected with the shared pipeline and the waste liquid discharging part through the fourth gating valve, and the first liquid sucking and discharging unit is connected with the positive and negative pressure source through the fifth gating valve.
4. A blood analyzer according to claim 3, wherein,
in the same sample preparation channel, the quantitative driving performance of the quantitative liquid sucking and discharging unit in the first reagent unit is different from the quantitative driving performance of the quantitative liquid sucking and discharging unit in the second reagent unit;
and/or, in different sample preparation channels, the opening and closing performances of the second gate valves in all the first reagent units are the same,
And/or, in different sample preparation channels, the opening and closing performances of the third gate valves in all the first reagent units are the same,
and/or, in different sample preparation channels, the opening and closing performances of the second gate valves in all the second reagent units are the same,
and/or, in different sample preparation channels, the opening and closing performances of the third gate valves in all the second reagent units are the same,
and/or, in different sample preparation channels, the quantitative driving performance of the quantitative liquid sucking and discharging units in all the first reagent units is the same;
and/or, in different sample preparation channels, the quantitative driving performance of the quantitative liquid sucking and discharging units in all the second reagent units is the same.
5. A blood analyzer according to claim 3, wherein,
the first and second reagent units each include a reagent suction tube and a reagent supply tube,
the reagent containing unit is connected with the quantitative liquid sucking and discharging unit through the reagent sucking pipe, and the quantitative liquid sucking and discharging unit is connected with the reaction tank unit through the reagent supply pipe;
the first characteristic parameters of the reagent suction pipes of all the first reagent units are the same;
And/or, second characteristic parameters of the reagent supply pipes of all the first reagent units are the same;
and/or, third characteristic parameters of the reagent suction pipes of all the second reagent units are the same;
and/or fourth characteristic parameters of the reagent supply pipes of all the second reagent units are the same;
and/or at least one first characteristic subparameter of the first characteristic parameters of the reagent aspiration tube of the first reagent unit and at least one third characteristic subparameter of the third characteristic parameters of the reagent aspiration tube of the second reagent unit are different in the same sample preparation channel;
and/or at least one second characteristic sub-parameter of the second characteristic parameters of the reagent supply tube of the first reagent unit is different from at least one fourth characteristic sub-parameter of the fourth characteristic parameters of the reagent supply tube of the second reagent unit in the same sample preparation channel.
6. A blood analyzer according to claim 3, wherein,
in the same sample preparation channel, the second gating valve and the third gating valve in the first reagent unit have the same electrical parameters,
And/or, in the same sample preparation channel, the second gating valve in the second reagent unit and the third gating valve have the same electrical parameters,
and/or, in different ones of said sample preparation channels, the electrical parameters of said second gate valves in all of said first reagent units are the same,
and/or, in different ones of said sample preparation channels, the electrical parameters of said third gate valves in all of said first reagent units are the same;
and/or, in different ones of said sample preparation channels, the electrical parameters of said second gate valves in all of said second reagent units are the same,
and/or, in different ones of said sample preparation channels, the electrical parameters of said third gate valves in all of said second reagent units are the same;
and/or the fourth gate valve and the fifth gate valve of the first liquid sucking and discharging unit have the same electrical parameters;
and/or the electrical parameters of the fourth gate valve of the first liquid sucking and discharging unit are the same as the electrical parameters of at least one of the second gate valves in the N sample preparation channels;
and/or the electrical parameters of the fifth gating valve of the first liquid sucking and discharging unit are the same as the electrical parameters of at least one third gating valve in the N sample preparation channels;
And/or, in different sample preparation channels, the electrical interfaces of the N first gate valves are connected with the same circuit board, and each first gate valve is driven by a MOS tube or triode with the same electrical parameter,
and/or, in different sample preparation channels, the electrical interfaces of the N second gate valves are connected with the same circuit board, and each second gate valve is driven by a MOS tube or triode with the same electrical parameter,
and/or, in different sample preparation channels, the electrical interfaces of the N third gating valves are connected with the same circuit board, and each third gating valve is driven by a MOS tube or triode with the same electrical parameters.
7. The blood analyzer according to any one of claims 2 to 6, further comprising a control unit, a drive unit and a cleaning unit; the driving unit is connected with the detection pool unit through a shared pipeline, and the cleaning unit is connected with the detection pool unit through the shared pipeline;
the control unit is used for:
when only one of the first gating valves is conducted, the sample preparation channel corresponding to the first gating valve in the conducted state is used for carrying out sample conveying under the driving action of the driving unit or is cleaned at least through the cleaning unit;
And/or when all N first gating valves are blocked, the shared pipeline and/or the detection pool unit are/is cleaned by the cleaning unit.
8. The blood analyzer of claim 7, wherein the blood analyzer comprises a blood analyzer,
when only one of the first gating valves is conducted and the sample preparation channel corresponding to the first gating valve in the conducted state is used for carrying out sample transportation, the sample in the sample preparation channel flows to the shared pipeline from the sample preparation channel through the conducted first gating valve;
when only one of the first gate valves is conducted and the sample preparation channel corresponding to the first gate valve in the conducted state is at least cleaned by the cleaning unit, the cleaning liquid of the cleaning unit flows to the sample preparation channel through the shared pipeline and the conducted first gate valve.
9. The blood analyzer according to claim 2, wherein at least two of the reaction cell units corresponding to the sample preparation channels are assembled and connected in a multi-cell form.
10. The blood analyzer of claim 9, wherein the blood analyzer comprises a blood analyzer,
the sample preparation channel further comprises a preheating part and a cleaning liquid supply unit, and the cleaning liquid supply unit is connected with the reaction tank unit;
The preheating part is used for heating the reagent supplied by the first reagent unit,
and/or for heating the reagent supplied by the second reagent unit,
and/or for heating the cleaning liquid supplied by the cleaning liquid supply unit.
CN202310390947.7A 2023-04-13 2023-04-13 blood analyzer Active CN116106525B (en)

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