CN114878846A - Blood analyzer and cleaning method thereof - Google Patents
Blood analyzer and cleaning method thereof Download PDFInfo
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- CN114878846A CN114878846A CN202210801639.4A CN202210801639A CN114878846A CN 114878846 A CN114878846 A CN 114878846A CN 202210801639 A CN202210801639 A CN 202210801639A CN 114878846 A CN114878846 A CN 114878846A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B2203/00—Details of cleaning machines or methods involving the use or presence of liquid or steam
- B08B2203/007—Heating the liquid
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
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Abstract
The application provides a blood analyzer, this blood analyzer includes: the blood analyzer comprises a liquid path part and a preheating part connected with the liquid path part, wherein the preheating part is used for receiving liquid to be detected and heating the liquid to be detected to a first temperature when a sample is detected by the blood analyzer so that the heated liquid to be detected enters the liquid path part for reaction and detection, and the liquid to be detected comprises a sample and/or a reagent; the preheating part is also used for receiving the cleaning liquid and heating the cleaning liquid to a second temperature when the blood analyzer is cleaned, and the heated cleaning liquid is used for cleaning the liquid path part so as to improve the cleaning effect of the liquid path part, wherein the second temperature is higher than the first temperature. The blood analyzer can improve the reliability of sample detection by reducing the influence of temperature on sample detection, and in addition, the cleaning effect of the blood analyzer can be improved by high-temperature cleaning.
Description
Technical Field
The application relates to the field of medical equipment, in particular to a blood analyzer and a cleaning method thereof.
Background
The sample analyzer is a medical precision instrument and can be used for analyzing and measuring blood samples, and the general working process is as follows: sucking a quantitative sample, pumping the sample into a reaction tank according to a preset dilution ratio by using a quantitative reagent, and sampling and parameter measurement after uniform mixing and reaction in the reaction tank are completed. The sample analyzer needs to be filled with cleaning fluid to perform daily/periodic cleaning of the fluid path. So that the next measurement is not affected by the last measurement.
Then, the blood analyzer in the prior art has poor cleaning effect and may cause the problem of carrying pollution.
Disclosure of Invention
The application provides a blood analyzer and a cleaning method thereof, which aim to solve the technical problems that the cleaning effect of the blood analyzer in the prior art is not good and the carrying pollution problem is possibly caused.
In order to solve the technical problem, the application adopts a technical scheme that: provided is a blood analyzer including: the blood analyzer comprises a liquid path part and a preheating part connected with the liquid path part, wherein the preheating part is used for receiving liquid to be detected and heating the liquid to be detected to a first temperature when a sample is detected by the blood analyzer so that the heated liquid to be detected enters the liquid path part for reaction and detection, and the liquid to be detected comprises a sample and/or a reagent; the preheating part is also used for receiving the cleaning liquid and heating the cleaning liquid to a second temperature when the blood analyzer is cleaned, and the heated cleaning liquid is used for cleaning the liquid path part so as to improve the cleaning effect of the liquid path part, wherein the second temperature is higher than the first temperature.
Further, the preheating part is used for: the cleaning liquid in the preheating part generates partial steam, so that a mixture of the cleaning liquid and the steam is formed, and the mixture is used for cleaning the liquid path part.
Further, the blood analyzer further comprises a driving part, the driving part is connected with the preheating part, and the driving part is used for: injecting the mixture into the liquid path portion based on the first pressure difference, the driving portion further for: injecting a reagent into the liquid path portion based on a second pressure difference, wherein the first pressure difference is greater than the second pressure difference.
Further, the driving part comprises a high-pressure plunger pump, and the material of the high-pressure plunger pump is ceramic.
Further, the blood analyzer further comprises an oscillating portion directly or indirectly connected to the liquid path portion, the oscillating portion repeatedly performing discharge of the liquid in the liquid path portion and filling of new liquid into the liquid path portion, wherein the concentration of the new liquid filled into the liquid path portion each time is less than or equal to the concentration of the liquid filled into the liquid path portion last time.
Further, the blood analyzer further includes an oscillating portion for: and enabling the liquid in the liquid path part to move back and forth based on preset configuration parameters so as to enable the liquid in the liquid path part to oscillate therein.
Further, the preset configuration parameters include: at least one of the concentration of the liquid, the pressure or intensity of the liquid, the length of the cleaning time, the cleaning direction, the soaking time and the concentration of the liquid, and the cleaning times.
Further, the liquid path portion comprises a reaction tank and a pipeline connected with the reaction tank, the pipeline comprises an inner pipe layer, an enhancement layer and a protection layer which are sequentially stacked, the enhancement layer is used for increasing the high-temperature resistance of the inner pipe layer, and the protection layer is used for protecting the enhancement layer and the inner pipe layer.
In order to solve the above technical problem, another technical solution adopted by the present application is: there is provided a method of cleaning a blood analyzer, the method being based on the blood analyzer of any of the above embodiments, specifically, the method includes: injecting a cleaning solution into the preheating part; heating the cleaning liquid to a second temperature by a preheating part; the liquid path part is cleaned by the heated cleaning liquid, so that the cleaning effect on the liquid path part is improved.
Further, heating the cleaning solution to a second temperature by the preheating section, including causing the cleaning solution to generate a portion of steam by the preheating section, thereby forming a mixture of the cleaning solution and the steam; the cleaning of the liquid path portion by the heated cleaning liquid includes cleaning of the liquid path portion by the mixture.
Further, injecting the cleaning liquid into the preheating part includes injecting the cleaning liquid into the preheating part when the liquid to be detected in the liquid path part is subjected to reaction and detection.
Further, the cleaning solution is heated to a second temperature by the preheating part, including the preheating part adding a preset cleaning substance into the preheating part when the cleaning solution is heated, wherein the preset cleaning substance includes at least one of a surfactant, an acidic cleaning substance and a basic cleaning substance.
Further, adding a predetermined cleaning substance into the pre-heating section, including adding a surfactant and an acid/alkaline cleaning substance into the pre-heating section simultaneously; alternatively, the surfactant and acid/alkaline cleaning substance are alternately added to the pre-heating section.
Further, the blood analyzer further comprises a driving part, the driving part is connected with the preheating part, the driving part injects the reagent into the liquid path part based on a second pressure difference, and the liquid path part is cleaned through the mixture.
Further, before the step of cleaning the liquid path portion with the heated cleaning liquid, the cleaning method further includes: and closing the valve of the pipeline which does not need to be cleaned in the liquid pipeline part. The liquid path portion further includes a detection portion, and after the step of cleaning the liquid path portion with the heated cleaning liquid, the cleaning method further includes: and performing blank sample test on the cleaned liquid path part through the detection part.
The beneficial effect of this application is: in contrast to the state of the art, the blood analyzer of the present application comprises: the blood analyzer comprises a liquid path part and a preheating part connected with the liquid path part, wherein the preheating part is used for receiving liquid to be detected and heating the liquid to be detected to a first temperature when a blood analyzer detects a sample so as to enable the heated liquid to be detected to enter the liquid path part for reaction and detection, the liquid to be detected comprises a sample and/or a reagent, namely, the preheating part is used for heating the liquid for reaction in the liquid path part so as to enable the temperature of the liquid to reach the reaction temperature, so that the accuracy of sample detection is improved; in addition, the preheating part is also used for receiving the cleaning liquid and heating the cleaning liquid to a second temperature when the blood analyzer is cleaned, and the heated cleaning liquid is used for cleaning the liquid path part so as to improve the cleaning effect of the liquid path part, wherein the second temperature is higher than the first temperature, namely, the preheating part heats the cleaning liquid into a liquid with a higher temperature when the cleaning liquid reacts relative to the cleaning liquid during cleaning, so that the cleaning effect can be enhanced, and the using amount of the cleaning liquid can be reduced.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, it is obvious that the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without inventive efforts, wherein:
FIG. 1 is a schematic block diagram of one embodiment of a blood analyzer provided herein;
FIG. 2 is a schematic block diagram of another embodiment of a blood analyzer provided herein;
FIG. 3 is a schematic block diagram of another embodiment of a blood analyzer provided herein;
FIG. 4 is a schematic flow diagram of one embodiment of a method for cleaning a blood analyzer provided herein;
FIG. 5 is a flowchart illustrating an embodiment of step S42 in FIG. 4.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
It should be noted that if directional indications (such as up, down, left, right, front, and back … …) are referred to in the embodiments of the present application, the directional indications are only used to explain the relative positional relationship between the components, the movement situation, and the like in a specific posture (as shown in the drawings), and if the specific posture is changed, the directional indications are changed accordingly.
In addition, if there is a description of "first", "second", etc. in the embodiments of the present application, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present application.
Referring to fig. 1, fig. 1 is a schematic structural diagram of an embodiment of the blood analyzer, and the blood analyzer 10 includes: a liquid path part 11 and a preheating part 12, wherein the liquid path part 11 is connected with the preheating part 12. The preheating part 12 can be used to heat the liquid to be detected, and the preheating part 12 can also be used to heat the cleaning liquid.
Specifically, the preheating section 12 may be configured to: when the blood analyzer 10 performs sample detection, the liquid to be detected is received and heated to a first temperature, so that the heated liquid to be detected enters the liquid path portion 11 for reaction and detection, and the liquid to be detected comprises one or more of a sample, sheath liquid and various reagents for reaction. That is, the preheating unit 12 can be used to heat the liquid to be reacted so as to satisfy the reaction conditions. The first heating temperature may be selected according to specific detection items, for example, the first heating temperature may be 37 degrees or 40 degrees.
The accuracy of the sample detection result can be improved by heating the liquid to be detected by the preheating part 12. For example, when liquid way portion 11 includes the counting cell, preheating portion 12 can heat the reagent of joining the forebay and the postbay, eliminates the forebay and the difference in temperature of postbay reagent of counting cell to can reduce the interference of the fine line signal in the counting channel that the difference in temperature caused, and then improve the accuracy of counting result.
In the present application, the preheating part 12 is further configured to receive the cleaning solution and heat the cleaning solution to a second temperature when the blood analyzer 10 is cleaned, and the heated cleaning solution is used for cleaning the liquid path part 11, where the second temperature is greater than the first temperature. For example, when the first temperature is 37 degrees, the second temperature may be 38 degrees, 40 degrees, or the like.
Specifically, the heating power of the preheating section 12 when the cleaning liquid is heated is higher than the power when the liquid to be detected is preheated. In this application, when blood analyzer 10 washs, pass through preheating portion 12 with the washing liquid for the washing liquid becomes the liquid of higher temperature when waiting to detect liquid reaction relatively, and high temperature enables greasy dirt, oil dirt, bloodiness and melts rapidly, consequently, through this kind of mode, can strengthen the cleaning performance, reduces the quantity of washing liquid.
Alternatively, when the solution to be detected in the liquid path portion 11 is reacted and detected, the cleaning solution may be injected into the preheating portion 12 and heated by the preheating portion 12, and after the detection of the solution to be detected in the liquid path portion 11 is completed, the heated cleaning solution may be directly used to clean the liquid path portion 11, and in this way, the cleaning time may be saved. It is understood that after the liquid to be detected in the liquid path portion 11 is detected, the cleaning liquid may be injected into the preheating portion 12 to be heated, so as to clean the liquid path portion 11 by the heated cleaning liquid.
Alternatively, the preheating part 12 heats the cleaning solution therein to a high temperature until a part of steam is generated, so as to form a mixture of the cleaning solution and the steam, and after the detection of the liquid path part 11 is completed, the high-temperature cleaning solution and the steam are injected into the liquid path part 11 to start cleaning. The cleaning effect can be improved by the mixture of the cleaning liquid and the steam.
The preheating part 12 may adopt a scheme of a heating rod plus a coil or a heating tank, and the structure of the preheating part 12 for heating the cleaning liquid therein is within the scope understood by those skilled in the art and will not be described in detail herein.
The pipelines and the tank body in the preheating part 12 and the liquid path part 11 can be made of high-temperature resistant materials. For example, the liquid path portion 11 includes a reaction tank and a pipeline connected to the reaction tank, the pipeline includes an inner pipe layer, an enhancement layer and a protection layer, which are sequentially stacked, the inner pipe layer is used for conveying liquid, the enhancement layer is used for increasing the high temperature resistance of the inner pipe layer, and the protection layer is used for protecting the enhancement layer and the inner pipe layer to prevent corrosion and mechanical damage. The inner pipe layer and the enhancement layer can be woven by steel wires, and generally 2-3 layers are provided.
Further, as shown in fig. 2, fig. 2 is a schematic structural diagram of another embodiment of the blood analyzer provided in the present application, in this embodiment, the blood analyzer 10 further includes a driving portion 13, the driving portion 13 is directly or indirectly connected to the preheating portion 12, and the driving portion 13 is configured to: the mixture is injected into the liquid path portion 11 based on the first pressure difference, and the driving portion 13 is also configured to: the reagent is injected into the liquid path portion 11 based on a second pressure difference, wherein the first pressure difference is larger than the second pressure difference. That is, the drive unit 13 injects a mixture of a high-temperature and high-pressure cleaning liquid and steam into the liquid path portion 11 to perform high-temperature steam jet cleaning on the liquid path portion 11.
The principle of high-temperature steam jet cleaning is as follows: pumping a mixture of high-pressure cleaning liquid and steam by a high-pressure pump, wherein the mixture of the cleaning liquid and the steam reaches a liquid injection port through a pipeline, and a nozzle converts the liquid with high pressure and low flow velocity into jet flow with low pressure and high flow velocity to impact the surface of a cleaned part (such as the liquid path part 11) positively or tangentially; the high temperature hot water vapor rapidly dissolves dirt on the surface of the object. The jet creates sufficient pressure on the scale or deposit to break it up, and once the scale is penetrated, the fluid is inserted in a wedge-like manner between the scale and the surface of the cleaning member, causing the scale to break off and expose the surface of the member being cleaned. The scale, which is layered or porous, is easily broken down because the impact of the jet hits a hole, creating an internal pressure below the scale surface that breaks the upper scale layer apart. In many spraying operations, the entrainment of the shattered particles in the jet can help to impact more particles.
Further, the driving part 13 may include a high pressure plunger pump, and the material of the high pressure plunger pump is ceramic. Because the ceramic material is high temperature resistant and wear resistant, the service life of the high-pressure plunger pump can be prolonged by using the ceramic material.
Further, as shown in fig. 3, fig. 3 is a schematic structural diagram of another embodiment of the blood analyzer provided by the present application, in this embodiment, the blood analyzer 10 further includes an oscillating portion 14, the oscillating portion 14 is directly or indirectly connected to the liquid path portion 11, and the oscillating portion 14 is used for moving the liquid in the liquid path portion 11 back and forth to oscillate the liquid in the liquid path portion 11, so that the cleaning effect of the liquid path portion 11 can be improved.
Specifically, the oscillating portion 14 may repeatedly perform the discharging of the liquid in the liquid path portion 11 and the filling of the liquid path portion 11 with new liquid, where the concentration of the new liquid filled in the liquid path portion 11 each time is less than or equal to the concentration of the liquid filled in the liquid path portion 11 last time. That is, during the cleaning process, the liquid in the liquid path portion 11 may be discharged first, and then a new liquid with a low concentration, which may be a waste liquid with a low concentration or a cleaning liquid with a low concentration, may be filled in, and then the liquid in the liquid path portion 11 may be emptied. Thus, the cleaning effect can be improved.
Optionally, the oscillating portion 14 may also be used to: the liquid in the liquid path portion 11 is made to come and go back and forth based on preset configuration parameters so that the liquid in the liquid path portion 11 oscillates therein. The oscillating unit 14 discharges the liquid in the liquid path unit 11, and then fills the discharged liquid into the liquid path unit 11, and the oscillating step is repeated several times, so that the shearing force generated by the oscillation can be utilized to strip off the pollutants adhered to the corners of the pipeline, and then partially dissolve into the cleaning liquid, and the liquid in the liquid path unit 11 is discharged through the emptying step. When the initial concentration is high, the number of oscillations may be small, and when the initial concentration is low, the number of oscillations may be increased, increasing the stripping effect of the contaminants. By the mode, the cleaning effect of the liquid path part 11 can be improved, and the detection efficiency of the whole machine is further improved.
The preset configuration parameters include: at least one of the concentration of the liquid, the pressure or intensity of the liquid, the length of the cleaning time, the cleaning direction, the soaking time and the concentration of the liquid, and the cleaning times. The concentration of the liquid comprises the concentration of the wash solution, in particular the concentration of the hemolysing agent in the wash solution. The direction of cleaning includes: the washing device comprises a front heating part, a back heating part, a spiral part or a back and forth part and a combination thereof, wherein the front heating part is a direction from a liquid path of the blood analyzer to a part to be washed in the liquid path part, and the front heating part and the back heating part are opposite directions. Namely, the cleaning effect can be effectively controlled by controlling the configuration parameters during the oscillation.
It can be understood that, after the liquid path portion 11 is filled with the liquid by the oscillating portion 14 for a plurality of times, the liquid in the liquid path portion 11 is moved in and out for a plurality of times to perform the oscillating cleaning, and in this way, the cleaning effect can be further improved.
During oscillation, the bubbles can be added by using the bubble generator, so that the liquid in the pipeline is in a gas-liquid two-phase flow state, the shearing force on the pipe wall during oscillation is further enhanced by using the cavitation effect of the bubbles, and the effect of stripping pollutants is enhanced. During the oscillation, after the oscillation has been carried out several times (but not evacuated), air bubbles can be added to enhance the cleaning effect.
Above-mentioned blood analyzer 10's simple structure can treat through preheating portion 12 and detect liquid and heat to the messenger waits to detect that liquid satisfies reaction temperature, through this kind of mode, can improve the accuracy that the sample detected, preheating portion 12 can also be used to heat the washing liquid, can improve the cleaning performance through high temperature cleaning.
Based on the above blood analyzer 10, the present application further provides a method for cleaning a blood analyzer, as shown in fig. 4, fig. 4 is a schematic flow chart of an embodiment of the method for cleaning a blood analyzer provided by the present application, and specifically, the method for cleaning a blood analyzer includes:
s41: the cleaning liquid is injected into the preheating portion.
In the above step, the cleaning solution is injected into the preheating part, and specifically, the cleaning solution may be injected into the preheating part when the solution to be detected in the solution path part is reacted and detected, so that the cleaning time of the blood analyzer can be saved. It can be understood that, also can wait to detect the liquid in the liquid path portion and accomplish the back, inject the washing liquid into preheating portion again, avoid preheating portion to wait to detect the measuring of liquid to the heating process influence of washing liquid, so, can improve the reliability that hematology analyzer detected.
S42: the cleaning liquid is heated to a second temperature by the preheating section.
By heating the cleaning liquid to the second temperature by the preheating part, wherein the second temperature is higher than the reaction temperature in the liquid path part, the liquid path part can be cleaned at high temperature by the way, so that the cleaning effect on the liquid path part is improved.
In a specific embodiment, the step of heating the cleaning liquid to the second temperature by the preheating part may include: the cleaning solution is partially vaporized by the preheating section to form a mixture of the cleaning solution and the vapor, so that the blood analyzer cleans the liquid path section by the mixture. That is, when the liquid path portion is cleaned, the liquid path portion can be cleaned by a mixture of the cleaning liquid and the steam, and thus, the cleaning effect can be improved.
Alternatively, as shown in fig. 5, the step of heating the cleaning liquid to the second temperature by the preheating part may further include:
s421: the preheating part is used for adding a preset cleaning substance into the preheating part when the cleaning liquid is heated, wherein the preset cleaning substance comprises at least one of a surfactant, an acidic cleaning substance and an alkaline cleaning substance.
Specifically, a surfactant refers to a compound that contains in its molecule at least one group with affinity for a significantly polar surface (to ensure its water solubility in most cases) and one non-polar group with poor affinity for a substance. Commonly used surfactants include ionic surfactants (including cationic surfactants and anionic surfactants), nonionic surfactants, and amphoteric surfactants.
The cleaning power of a surfactant results from its ability to reduce the oil-water interfacial tension (degreasing), i.e., the detersive power of a surfactant, in its ability to wet a stained surface and emulsify it, i.e., "wrap" the soil, allowing it to emulsify in water and be washed away. While the ability of the surfactant to reduce oil-water interfacial tension (degreasing) is further enhanced as the temperature increases.
The surfactant can effectively dissolve bloody stain stains, has hydrophilic and lipophilic groups, and can obviously reduce the surface tension of the solution, thereby increasing the solubility. Normally, blood is a suspension and cannot "fuse" with water. The surfactant can wrap blood stains into small liquid drops, so that the blood stains attached to a liquid path are more easily dissolved in water, and the solubility of the blood stains is increased due to the addition of the surfactant, thereby achieving the purpose of cleaning a pipeline.
The alkaline cleaning component can be sodium hydroxide, and as a common strong base, the alkaline cleaning component can perform hydrolysis reaction with common liquid dirt such as esters and proteins in blood dirt. Thus, the insoluble solid matter is hydrolyzed into soluble matter, and the insoluble solid matter is softened or reduced in volume to further reduce the contamination in the liquid path portion.
Alternatively, the step of adding a predetermined cleaning substance to the preheating section may include adding a surfactant and an acid/alkaline cleaning substance simultaneously to the preheating section; alternatively, a surfactant and an acid/alkaline cleaning substance are alternately added to the preheating part to enhance the cleaning effect on the liquid path part. The alternate addition is understood to mean that when multiple cleanings of the liquid path portion are required, a surfactant may be added at A, B th cleaning, an acid/alkaline cleaning substance may be added at C th cleaning, and a surfactant and an acid/alkaline cleaning substance may be added at D, E, F th cleaning, wherein A, B, C, D, E, F are natural numbers other than 0 and A, B, C, D, E, F are different from each other. The alternate addition may also be understood as adding at least one of a surfactant and an acid/alkaline cleaning substance at a first time and adding at least one of a surfactant and an acid/alkaline cleaning substance at a second time, the second time being later than the first time, when cleaning is performed on the fluid path portion.
S43: the liquid path part is cleaned by the heated cleaning liquid, so that the cleaning effect on the liquid path part is improved.
After the heated cleaning liquid is obtained, the liquid path part can be cleaned by the heated cleaning liquid, so that the cleaning effect on the liquid path part is improved.
Further, the blood analyzer further includes a driving portion that can be used to inject the heated cleaning liquid into the liquid path portion to clean the liquid path portion.
In a specific embodiment, the step of cleaning the liquid path portion with the mixture may include: and injecting the mixture into the liquid path part by the driving part based on the first pressure difference so as to clean the liquid path part by high-temperature steam jet. Wherein, the drive division injects reagent into the liquid way portion based on the second pressure differential, and first pressure differential is greater than the second pressure differential, can carry out high temperature jet flow to the liquid way portion through this kind of mode and wash to further improve cleaning performance.
When the liquid path part is cleaned, the valve of the pipeline which does not need to be cleaned in the liquid path part can be closed, so that the complexity of cleaning control is reduced, and the cleaning time is saved. Further, the liquid path portion may include a detection portion, the detection portion is configured to perform detection and analysis on a sample, and after the liquid path portion is cleaned, a blank sample test may be performed on the cleaned liquid path portion through the detection portion, so as to determine whether the liquid path portion is cleaned according to a test result. For example, the blank sample test is performed by a sheath flow impedance or sheath flow optical flow chamber, and the blank sample is directly passed through the flow chamber to perform the blank sample test without opening a sheath flow portion during the test, so as to obtain the test result. Through this kind of mode, can accurately judge whether the liquid way portion sanitizes, after the liquid way portion sanitizes, just make blood analysis appearance carry out the detection of next sample, so, can improve blood analysis appearance's reliability.
To sum up, in the cleaning method of this application, pass through preheating portion with the washing liquid for the washing liquid becomes the liquid of higher temperature when waiting to detect liquid reaction relatively, and high temperature enables greasy dirt, bloodiness and melts rapidly, and high pressure rivers can take away these melts again, and consequently, the cleaning performance can be strengthened to the method of this application, reduces the washing liquid quantity, has stronger practicality.
The above embodiments are merely examples and are not intended to limit the scope of the present disclosure, and all modifications, equivalents, and flow charts using the contents of the specification and drawings of the present disclosure, which are directly or indirectly applied to other related technical fields, are included in the scope of the present disclosure.
Claims (15)
1. A blood analyzer, comprising:
the blood analyzer comprises a liquid path part and a preheating part connected with the liquid path part, wherein the preheating part is used for receiving liquid to be detected and heating the liquid to be detected to a first temperature when the blood analyzer detects a sample, so that the heated liquid to be detected enters the liquid path part for reaction and detection, and the liquid to be detected comprises a sample and/or a reagent;
the preheating part is further used for receiving a cleaning solution when the blood analyzer is cleaned, heating the cleaning solution to a second temperature, and the heated cleaning solution is used for cleaning the liquid path part to improve the cleaning effect of the liquid path part, wherein the second temperature is higher than the first temperature.
2. The blood analyzer of claim 1, wherein the pre-heating portion is configured to: and generating partial steam from the cleaning liquid in the preheating part so as to form a mixture of the cleaning liquid and the steam, wherein the mixture is used for cleaning the liquid path part.
3. The blood analyzer of claim 2, further comprising a drive section connected to the pre-heating section, the drive section configured to: injecting the mixture into the liquid path portion based on a first pressure differential, the drive portion further to: injecting the reagent into the fluid path portion based on a second pressure differential, wherein the first pressure differential is greater than the second pressure differential.
4. The blood analyzer of claim 3, wherein the drive portion comprises a high pressure plunger pump, the material of the high pressure plunger pump being ceramic.
5. The blood analyzer of claim 1, further comprising an oscillating portion directly or indirectly connected to the fluid path portion,
the oscillating part repeatedly discharges the liquid in the liquid path part and fills new liquid into the liquid path part, wherein the concentration of the new liquid filled into the liquid path part every time is less than or equal to that of the liquid filled into the liquid path part last time.
6. The blood analyzer of claim 1, further comprising an oscillating portion for: and enabling the liquid in the liquid path part to move in and out based on preset configuration parameters so as to enable the liquid in the liquid path part to oscillate therein.
7. The blood analyzer of claim 6, wherein the preset configuration parameters include: at least one of the concentration of the liquid, the pressure or intensity of the liquid, the length of the cleaning time, the cleaning direction, the soaking time and the concentration of the liquid, and the cleaning times.
8. The blood analyzer of claim 1, wherein the fluid path portion comprises a reaction cell and a pipeline connected to the reaction cell, the pipeline comprises an inner tube layer, a reinforcement layer and a protection layer, the inner tube layer, the reinforcement layer and the protection layer are sequentially stacked, the reinforcement layer is used for increasing the high temperature resistance of the inner tube layer, and the protection layer is used for protecting the reinforcement layer and the inner tube layer.
9. A method of cleaning a blood analyzer, based on the blood analyzer according to any one of claims 1 to 8, the method comprising:
injecting the cleaning solution into the preheating part;
heating the cleaning liquid to the second temperature by the preheating part;
and cleaning the liquid path part by the heated cleaning liquid so as to improve the cleaning effect on the liquid path part.
10. The cleaning method according to claim 9, wherein the heating the cleaning liquid to the second temperature by the preheating part includes,
causing the cleaning solution to generate a portion of steam by the pre-heating portion, thereby forming a mixture of the cleaning solution and the steam;
the cleaning of the liquid path part by the heated cleaning liquid includes,
and cleaning the liquid path part by the mixture.
11. The cleaning method according to claim 9, wherein injecting the cleaning liquid into the pre-heating portion includes,
and when the liquid to be detected in the liquid path part is reacted and detected, injecting the cleaning liquid into the preheating part.
12. The cleaning method according to claim 9, wherein the heating the cleaning liquid to the second temperature by the preheating part includes,
when the preheating part heats the cleaning solution, a preset cleaning substance is added into the preheating part, wherein the preset cleaning substance comprises at least one of a surfactant, an acidic cleaning substance and an alkaline cleaning substance.
13. The cleaning method according to claim 12, wherein said adding a predetermined cleaning substance into said preheating section comprises,
adding the surfactant and the acid/base cleaning substance simultaneously into the pre-heat section; alternatively, the first and second electrodes may be,
alternately adding the surfactant and the acid/base cleaning substance to the pre-heat section.
14. The washing method according to claim 10, wherein the blood analyzer further includes a driving section connected to the preheating section, the driving section injecting the reagent into the liquid path section based on a second pressure difference,
the cleaning of the liquid path portion by the mixture includes,
and enabling the driving part to inject the mixture into the liquid path part based on a first pressure difference to perform high-temperature steam jet cleaning on the liquid path part, wherein the first pressure difference is larger than the second pressure difference.
15. The cleaning method according to claim 9, wherein before the step of cleaning the liquid path portion with the heated cleaning liquid, the cleaning method further comprises:
a valve of a pipeline which does not need to be cleaned in the liquid pipeline part is closed,
the liquid path portion further includes a detection portion, and after the step of cleaning the liquid path portion with the heated cleaning liquid, the cleaning method further includes:
and carrying out blank sample test on the cleaned liquid path part through the detection part.
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| CN116106525A (en) * | 2023-04-13 | 2023-05-12 | 深圳市帝迈生物技术有限公司 | Blood analyzer |
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