CN114871210B - Cleaning method of sample analyzer, sample analyzer and control device thereof - Google Patents
Cleaning method of sample analyzer, sample analyzer and control device thereof Download PDFInfo
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- CN114871210B CN114871210B CN202210801321.6A CN202210801321A CN114871210B CN 114871210 B CN114871210 B CN 114871210B CN 202210801321 A CN202210801321 A CN 202210801321A CN 114871210 B CN114871210 B CN 114871210B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
- B08B9/027—Cleaning the internal surfaces; Removal of blockages
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B13/00—Accessories or details of general applicability for machines or apparatus for cleaning
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Abstract
The application discloses cleaning method, sample analysis appearance and controlling means of sample analysis appearance, this cleaning method includes: after the sample analysis module finishes sample analysis operation, the processing module determines a cleaning mode of the sample analysis module and cleans the sample analysis module based on the determined cleaning mode; if the cleaning mode is determined to be the first cleaning mode, cleaning the sample analysis module by the cleaning module in a first time length by adopting the cleaning solution with the first concentration; if the cleaning mode is determined to be the second cleaning mode, cleaning the sample analysis module by the cleaning module by adopting the cleaning solution with the second concentration within the second time period; wherein the first concentration is greater than the second concentration, and/or the first duration is less than the second duration. Based on the mode, the rationality of the cleaning method of the sample analyzer can be effectively improved, and the cleaning cost can be reduced on the premise of ensuring the cleaning effect.
Description
Technical Field
The present disclosure relates to the field of sample testing technologies, and in particular, to a cleaning method for a sample analyzer, and a control device thereof.
Background
In the prior art, after a sample analyzer completes a sample analysis operation, preparation for the next sample analysis operation is usually required, for example, the sample analyzer needs to be cleaned, so as to avoid that substances remaining in the sample analyzer affect the result of the next sample analysis operation.
The defects of the prior art are that no matter what sample analysis operation is completed by the sample analyzer, what sample is analyzed, what amount of sample is used, what time length of analysis is, and finally adopted cleaning modes of the sample analyzer cannot be changed, so that the cleaning strength of the adopted cleaning modes is generally stronger, and further the cleaning cost of the sample analyzer is higher.
Disclosure of Invention
The technical problem that this application mainly solved is how to reduce the cleaning cost under the prerequisite of guaranteeing the cleaning performance.
In order to solve the above technical problem, the first technical solution adopted by the present application is: a method for cleaning a sample analyzer, the sample analyzer comprises a sample analysis module, a cleaning module and a processing module; the cleaning method comprises the following steps: after the sample analysis module completes sample analysis operation, the processing module determines a cleaning mode of the sample analysis module and cleans the sample analysis module based on the determined cleaning mode: if the cleaning mode is determined to be the first cleaning mode, cleaning the sample analysis module by the cleaning module in a first time length by adopting the cleaning solution with the first concentration; if the cleaning mode is determined to be the second cleaning mode, cleaning the sample analysis module by the cleaning module by adopting the cleaning solution with the second concentration within the second time period; wherein the first concentration is greater than the second concentration, and/or the first duration is less than the second duration.
Wherein the cleaning solution comprises a cleaning reagent and/or a diluting reagent, and the cleaning reagent is different from the diluting reagent; the first concentration is a concentration of the cleaning reagent or the diluting reagent in the cleaning liquid used in the first cleaning mode, and the second concentration is a concentration of the cleaning reagent or the diluting reagent in the cleaning liquid used in the second cleaning mode.
Wherein the first duration is less than the second duration; the cleaning module adopts the cleaning solution of second concentration, washs sample analysis module in the second duration, includes: the cleaning module injects cleaning liquid with a second concentration into a path of the sample analysis module needing cleaning liquid; the cleaning module oscillates the cleaning liquid with the second concentration in the liquid path to be cleaned, and/or the cleaning module enables the liquid path to be cleaned to be soaked in the cleaning liquid with the second concentration for a preset soaking time; the cleaning module discharges the liquid in the liquid path to be cleaned.
Wherein, the washing liquid of the second concentration in the washing module oscillation need washing liquid way includes: determining a target frequency based on the second concentration, wherein the target frequency and the second concentration are in a negative correlation relationship; the cleaning module oscillates the cleaning solution with the second concentration in the solution path to be cleaned until the oscillation frequency reaches the target frequency.
Wherein, the washing module oscillation needs the washing liquid of the second concentration in the washing liquid way, includes: the cleaning module oscillates the cleaning liquid with the second concentration in the liquid path to be cleaned, and bubbles are introduced into the liquid path to be cleaned when the oscillation is executed and/or after the oscillation is executed.
Wherein, to needing to wash the liquid way and letting in the bubble, include: introducing air bubbles into the liquid path to be cleaned and injecting a surface active reagent.
The sample analysis module comprises a blood routine module and a specific protein detection module, wherein the blood routine module is used for classifying and/or counting blood cells in the sample, and the specific protein detection module is used for detecting specific protein in the sample; cleaning a sample analysis module, comprising: the step of repeatedly executing the steps that the cleaning module cleans the blood routine module by adopting cleaning liquid in a corresponding cleaning mode and cleaning the specific protein detection module by adopting target cleaning liquid until the repeated execution times reach a preset repeated time, wherein the target cleaning liquid is the cleaning liquid which takes the liquid discharged after cleaning the blood routine module as a diluting reagent; the cleaning module adopts cleaning liquid in a corresponding cleaning mode to clean the specific protein detection module.
Wherein the sample analyzer further comprises a contamination detection module; after cleaning the sample analysis module based on the determined cleaning manner, the cleaning method further includes: the pollution detection module detects the pollution degree of the sample analysis module; and if the pollution degree is greater than the first preset pollution degree threshold value, returning to the step of determining the cleaning mode of the sample analysis module by the execution processing module and the subsequent steps.
Wherein the processing module determines a cleaning mode of the sample analysis module, comprising: if the pollution degree is greater than a second preset pollution degree threshold value, determining that the cleaning mode of the sample analysis module is a first cleaning mode; if the pollution degree is less than or equal to a second preset pollution degree threshold value, determining that the cleaning mode of the sample analysis module is a second cleaning mode; the second predetermined contamination level threshold is greater than the first predetermined contamination level threshold.
Wherein, pollution detection module detects the pollution degree, includes: the pollution detection module detects the pollution degree based on the impedance detection component and/or the optical detection component.
Wherein, the cleaning mode also comprises a pre-cleaning mode; the processing module determines a cleaning mode of the sample analysis module, comprising: if the sample analysis module is not cleaned after the sample analysis module completes sample analysis operation, the processing module determines that the cleaning mode of the sample analysis module is a pre-cleaning mode; if the sample analysis module is cleaned after the sample analysis module finishes sample analysis operation, the processing module determines that the cleaning mode of the sample analysis module is a first cleaning mode or a second cleaning mode; the cleaning method further comprises the following steps: if the cleaning mode is determined to be the pre-cleaning mode, the cleaning module cleans the sample analysis module within a third time period; wherein the third duration is associated with a sample analysis job.
Wherein, the washing module adopts the washing liquid of first concentration, washs sample analysis module in first duration, includes: the cleaning module adopts cleaning liquid with a first concentration, and cleans the sample analysis module for a first time within a first time length according to the pressure and/or the flowing direction of the first cleaning liquid; the cleaning module adopts the cleaning solution of second concentration, washs sample analysis module in the second duration, includes: and the cleaning module adopts the cleaning solution with the second concentration, and cleans the sample analysis module for a second time within a second time length according to the pressure and/or the flow direction of the second cleaning solution.
Wherein, wash sample analysis module, include: determining a liquid path needing cleaning and a liquid path needing no cleaning in the sample analysis module based on the processing module; the sample analysis module controls a liquid path needing cleaning to be opened and controls a liquid path needing no cleaning to be closed; and the cleaning module adopts cleaning liquid in a corresponding cleaning mode to clean the sample analysis module.
In order to solve the above technical problem, the second technical solution adopted by the present application is: a sample analyzer comprises a sample analysis module, a cleaning module and a processing module; the processing module is used for determining a cleaning mode of the sample analysis module after the sample analysis module finishes sample analysis operation, and controlling the cleaning module to clean the sample analysis module based on the determined cleaning mode; the cleaning module is used for: if the cleaning mode is determined to be the first cleaning mode, cleaning the sample analysis module by adopting the cleaning solution with the first concentration within the first time length; if the cleaning mode is determined to be the second cleaning mode, cleaning the sample analysis module by adopting the cleaning solution with the second concentration within the second time length; wherein the first concentration is greater than the second concentration, and/or the first duration is less than the second duration.
In order to solve the above technical problem, the third technical solution adopted by the present application is: a control device for a sample analyzer, comprising a processing module; the processing module is used for: after a sample analysis module of the sample analyzer completes sample analysis operation, determining a cleaning mode of the sample analysis module, and controlling the cleaning module of the sample analyzer to clean the sample analysis module based on the determined cleaning mode; if the cleaning mode is determined to be the first cleaning mode, controlling a cleaning module of the sample analyzer to clean the sample analysis module within a first time period by adopting cleaning liquid with a first concentration; if the cleaning mode is determined to be the second cleaning mode, the cleaning module is controlled to adopt the cleaning solution with the second concentration, and the sample analysis module is cleaned within a second time period; wherein the first concentration is greater than the second concentration, and/or the first duration is less than the second duration.
The beneficial effect of this application lies in: different from the prior art, in the technical scheme of the application, after the sample analysis module completes the sample analysis operation, the processing module can be adopted to determine the cleaning mode of the sample analysis module, and the cleaning mode can be determined to be a first cleaning mode or a second cleaning mode, wherein the first cleaning mode is higher in concentration of the adopted cleaning liquid and/or shorter in cleaning time compared with the second cleaning mode. Based on the above mode, the accessible sets up two kinds of cleaning methods of first cleaning method and second cleaning method, and two kinds of cleaning methods are different and have corresponding application condition respectively, can select one kind of cleaning method that wherein is more suitable to wash sample analyzer through processing module to avoid adopting the too high or long too long cleaning method of washing time of washing liquid concentration to wash and increase unnecessary cost sample analyzer, reduced the cleaning cost under the prerequisite of guaranteeing the cleaning performance.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the description below are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic block diagram of an embodiment of a sample analyzer of the present application;
FIG. 2 is a schematic flow chart diagram of one embodiment of a method for cleaning a sample analyzer of the present application;
FIG. 3 is a schematic block diagram of another embodiment of a sample analyzer of the present application;
fig. 4 is a schematic configuration diagram of an embodiment of a control device of the sample analyzer of the present application.
Detailed Description
The present application will be described in further detail with reference to the following drawings and examples. It is to be noted that the following examples are only illustrative of the present application, and do not limit the scope of the present application. Likewise, the following examples are only some examples and not all examples of the present application, and all other examples obtained by a person of ordinary skill in the art without any inventive step are within the scope of the present application.
Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the application. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is explicitly and implicitly understood by one skilled in the art that the embodiments described herein can be combined with other embodiments.
Throughout the description of the present application, it is intended that the terms "mounted," "disposed," "connected," and "connected" be construed broadly and encompass, for example, fixed connections, removable connections, or integral connections unless expressly stated or limited otherwise; can be mechanically connected or electrically connected; they may be directly connected or may be connected via an intermediate medium. To one of ordinary skill in the art, the foregoing may be combined in any suitable manner with the specific meaning ascribed to the present application.
Referring to fig. 1, fig. 1 is a schematic structural diagram of an embodiment of the sample analyzer, and as shown in fig. 1, a sample analyzer 10 includes a sample analysis module 11, a cleaning module 12, and a processing module 13.
Referring to fig. 2, fig. 2 is a schematic flow chart of an embodiment of a cleaning method of the sample analyzer of the present application, and as shown in fig. 2, the cleaning method includes:
step S11: after the sample analysis module 11 completes the sample analysis operation, the processing module 13 determines a cleaning manner of the sample analysis module 11, and cleans the sample analysis module 11 based on the determined cleaning manner.
After the sample analysis module 11 completes the sample analysis operation, the cleaning manner of the sample analysis module 11 may be determined based on the type of the sample analyzed in the completed sample analysis operation, the cleaning manner of the sample analysis module 11 may also be determined based on the usage amount of the sample in the completed sample analysis operation, and the cleaning manner of the sample analysis module 11 may also be determined based on other methods, which is not limited herein.
Step S12: if the cleaning mode is determined to be the first cleaning mode, the cleaning module adopts the cleaning solution with the first concentration to clean the sample analysis module within the first time period.
Step S13: and if the cleaning mode is determined to be the second cleaning mode, cleaning the sample analysis module by the cleaning module in the second time period by adopting the cleaning solution with the second concentration.
The step S12 and the step S13 do not have a fixed sequence, but are selected to be executed. When it is determined that the cleaning mode is the first cleaning mode, step S12 is performed, and when it is determined that the cleaning mode is the second cleaning mode, step S13 is performed, alternatively.
In addition, for the first cleaning mode and the second cleaning mode, the first concentration is greater than the second concentration, and/or the first duration is less than the second duration. The higher the concentration of the cleaning liquid is, the stronger the cleaning effect is under the same cleaning time. The longer the cleaning time is, the stronger the cleaning effect is under the same concentration of the cleaning liquid.
It should be noted that when the first concentration is greater than the second concentration and the first duration is less than the second duration, the concentration of the cleaning solution in the first cleaning manner may be greater than that in the second cleaning manner, so that the first cleaning manner having a shorter cleaning duration than the second cleaning manner may have a cleaning effect equal to or greater than that of the second cleaning manner. By this way, a first cleaning mode in which the cleaning time period is a first time period and a second cleaning mode in which the cleaning time period is a second time period can be constructed.
First, in practice, the number of sample analysis jobs that may be performed may vary from time to time. When the number of sample analysis operations to be performed is large, that is, the task load is heavy, the cleaning mode may be determined as the first cleaning mode, and the sample analysis module 11 is cleaned in a mode of short duration and high concentration of the cleaning solution, so that the cleaning duration is reduced while the cleaning effect is not reduced, and the time for performing the sample analysis operations is saved as much as possible. When the number of sample analysis operations to be performed is small, that is, the task amount is relatively free, the cleaning mode may be determined as the second cleaning mode, and the sample analysis module 11 is cleaned in a mode of long duration and low cleaning solution concentration, so that the cost of the cleaning solution can be reduced, and the cleaning effect is maintained through long-time cleaning, and the cleaning cost is reduced. For example, in the morning, the number of sample analysis operations is generally high in the clinical laboratory, and the first cleaning method is suitable, in the afternoon or evening, the number of sample analysis operations is generally low in the clinical laboratory, and the second cleaning method is suitable.
Secondly, in practice, the sample analysis module 11 may perform different sample analysis operations, for example: blood routine analysis and specific protein analysis. For different types of samples, the contamination conditions in the sample analysis module 11 caused by the different types of samples are different, the cleaning effect by the first cleaning method is better under a part of the contamination conditions, and the cleaning effect by the second cleaning method is best under a part of the contamination conditions.
Therefore, two cleaning modes are constructed, and one cleaning mode is selected to clean the sample analysis module 11 according to actual conditions, so that the applicability of the cleaning modes can be improved, and the cleaning cost can be reduced on the premise of ensuring the cleaning effect.
Different from the prior art, in the technical scheme of the application, after the sample analysis module completes the sample analysis operation, the processing module can be adopted to determine the cleaning mode of the sample analysis module, and the cleaning mode can be determined to be a first cleaning mode or a second cleaning mode, wherein the first cleaning mode is higher in concentration of the adopted cleaning liquid and/or shorter in cleaning time compared with the second cleaning mode. Based on the above mode, the two cleaning modes including the first cleaning mode and the second cleaning mode can be set, the two cleaning modes are different and have corresponding application conditions respectively, one of the more suitable cleaning modes can be selected through the processing module to clean the sample analyzer, unnecessary cost is increased due to the fact that the sample analyzer is cleaned by the cleaning mode with too high cleaning liquid concentration or too long cleaning time, and cleaning cost is reduced on the premise that the cleaning effect is guaranteed.
In an embodiment, the cleaning fluid comprises a cleaning reagent and/or a diluting reagent.
Wherein the cleaning reagent is different from the diluting reagent, the first concentration is a concentration of the cleaning reagent or the diluting reagent in the cleaning solution used in the first cleaning mode, and the second concentration is a concentration of the cleaning reagent or the diluting reagent in the cleaning solution used in the second cleaning mode.
In particular, the respective concentrations can be understood as: in the cleaning solution in the corresponding cleaning mode, the amount of the cleaning reagent accounts for the concentration of the total amount of the cleaning reagent and the diluting reagent (i.e., the cleaning solution). In some examples, the respective concentrations may also be understood as: the concentration of the cleaning reagent is determined when the pure cleaning reagent is used as the cleaning solution in the corresponding cleaning mode. In other examples, the respective concentrations may also be understood as: when pure diluting reagent is adopted as the cleaning solution in a corresponding cleaning mode, the concentration of the reagent is diluted.
The cleaning reagent may be a reagent capable of cleaning the contaminants in the sample analysis module 11, and the cleaning function may be a physical cleaning function, a chemical cleaning function, or a combination of the physical and chemical cleaning functions, which is not limited herein. For example, the cleaning reagent may include a cleaning solution, a hemolytic agent, a surfactant, and other types of reagents having cleaning capability, and the cleaning reagent may be classified into an acidic cleaning reagent, a neutral cleaning reagent, and an alkaline cleaning reagent according to a ph value, or may be classified into an enzyme-containing cleaning reagent and a non-enzyme-containing cleaning reagent according to whether an enzyme is contained, and the bio-enzyme may rapidly and effectively digest blood cells remaining on the inner wall of the sample analysis module 11, thereby enhancing a cleaning effect on the blood cells, or may be classified into an oxidation-based cleaning reagent and a non-oxidation-based cleaning reagent according to whether a cleaning effect is achieved by an oxidation reaction.
The hemolytic agent can, on one hand, lyse the erythrocytes, so that hemoglobin in the cells is released for hemoglobin measurement, and on the other hand, the hemolytic agent can, after destroying the erythrocytes, eliminate interference of the erythrocytes and erythrocyte debris on the leucocyte analysis, so as to facilitate leucocyte counting and classification in the subsequent sample analysis operation.
The cleaning ability of a surfactant is related to the basic properties of the surfactant, such as surface (interfacial) tension, interfacial adsorption, emulsifying and emulsion stability, dispersibility, solubility, detergency, and the application properties of the surfactant. The surfactant can increase the permeability of cell membrane, even dissolve cell membrane, and reduce surface tension, to enhance cleaning effect.
The diluting reagent may be a reagent that only serves a physical cleaning function, without any chemical reaction with contaminants, such as residual sample or derivatives of the sample. By way of example, the diluting-type reagent may include a diluent, ultrapure water, deionized water, RO water, distilled water, double distilled water, and other types of diluting reagents.
It should be noted that, since the use cost of the washing reagent is generally higher than that of the diluting reagent, based on the above-described manner, the sample analysis module 11 can be washed with the washing liquid containing the washing reagent at a high concentration only when necessary, and the sample analysis module 11 can be washed with the washing liquid containing the washing reagent at a low concentration or the washing liquid containing the pure diluting reagent when unnecessary, so as to reduce the washing cost while ensuring the washing effect.
Alternatively, the sample analysis module 11 may include a blood-routine module for classifying and/or counting blood cells in the sample and a specific protein detection module for detecting a specific protein in the sample.
The cleaning of the sample analysis module 11 in step S12 and/or step S13 includes:
and repeatedly executing the steps of cleaning the blood routine module by the cleaning solution in the corresponding cleaning mode and cleaning the specific protein detection module by the target cleaning solution until the repeated execution times reach the preset repeated times, wherein the target cleaning solution is the cleaning solution taking the liquid discharged after cleaning the blood routine module as the diluting reagent.
The cleaning module 12 cleans the specific protein detection module by using a cleaning solution in a corresponding cleaning manner.
Specifically, after determining that the cleaning manner is the first cleaning manner or the second cleaning manner, the sample analysis module 11 may be cleaned based on the cleaning solution in the corresponding cleaning manner, and the specific process is as follows:
the blood routine module can be cleaned by cleaning liquid in a corresponding cleaning mode, corresponding discharged liquid is discharged after the blood routine module is cleaned, cleaning reagents capable of cleaning blood cells are arranged in the discharged liquid, the cleaning reagents can also be used for cleaning specific protein generally, so that the specific protein detection module can be cleaned by using the discharged liquid, and steps related to the content in the section are repeatedly executed until the repeated execution times reach preset repeated times. And then, cleaning the specific protein detection module by adopting a cleaning solution in a corresponding cleaning mode to ensure that the pollutants in the specific protein detection module are completely removed.
Based on the mode, the utilization rate of the cleaning reagent can be improved, the using amount of the cleaning reagent is reduced, and the cleaning cost is reduced on the premise of ensuring the cleaning effect.
In one embodiment, the first duration is less than the second duration.
The step S13 of cleaning the sample analysis module 11 with the cleaning solution of the second concentration in the cleaning module 12 within the second time period may specifically include:
the cleaning module 12 injects a cleaning solution of a second concentration into the cleaning solution required path of the sample analysis module 11.
The cleaning module 12 oscillates the cleaning solution with the second concentration in the path of the cleaning solution to be cleaned, and/or the cleaning module 12 soaks the path of the cleaning solution to be cleaned in the cleaning solution with the second concentration for a preset soaking time.
The cleaning module 12 discharges the liquid in the path of the liquid to be cleaned.
Specifically, when the second cleaning mode is longer than the cleaning time corresponding to the first cleaning mode, in the second cleaning mode, because the cleaning time is longer, after the cleaning solution with the second concentration is injected into the path to be cleaned, the cleaning solution can be oscillated to separate the pollutants adhered to the pipeline wall in the path to be cleaned from the path to be cleaned, and/or the cleaning solution is soaked in the path to be cleaned for a preset soaking time to soften the pollutants, and then the liquid in the path to be cleaned is discharged as waste liquid.
Based on the mode, the cleaning capacity of the cleaning liquid can be improved, and the cleaning effect of the cleaning method can be improved.
Optionally, the washing module 12 oscillates the washing liquid with the second concentration in the path of the washing liquid, including:
a target number is determined based on the second concentration, the target number having a negative correlation with the second concentration.
The cleaning module 12 oscillates the cleaning solution of the second concentration in the path of the cleaning solution until the number of oscillations reaches the target number.
Specifically, the higher the second concentration is, the stronger the cleaning ability of the cleaning liquid itself is, and therefore the lower the number of required oscillations is, whereas the lower the second concentration is, the weaker the cleaning ability of the cleaning liquid itself is, and therefore the number of required oscillations is, the higher the number of times.
Based on the mode, the number of times of required oscillation can be determined according to the concentration of the cleaning liquid, so that the number of times of oscillation is more reasonable, the reasonability and the reliability of the cleaning method are improved, and the detection efficiency of the whole machine is improved.
Optionally, the washing module 12 oscillates the washing liquid with the second concentration in the path of the washing liquid, including:
the cleaning module 12 oscillates the cleaning solution of the second concentration in the path of the solution to be cleaned, and bubbles are introduced into the path of the solution to be cleaned while and/or after the oscillation is performed.
Specifically, based on the above manner, the shearing force of the cleaning liquid on the pipe wall during oscillation can be enhanced by the cavitation effect of the bubbles, so as to enhance the cleaning effect of the cleaning liquid for stripping off the pollutants.
Further, the step of introducing bubbles into the liquid path to be cleaned comprises the following steps:
introducing air bubbles into the path of the liquid to be cleaned and injecting a surface active reagent.
Specifically, the efficiency of bubble generation can be improved by the surfactant, and the cleaning effect of the cleaning liquid for removing the contaminants can be further enhanced.
In one embodiment, the cleaning module 12 in step S12 cleans the sample analysis module 11 with the cleaning solution of the first concentration for a first duration, which includes:
the cleaning module 12 performs a first number of cleanings of the sample analysis module 11 within a first time period by using a first concentration of the cleaning solution and using a first cleaning solution pressure and/or a first cleaning solution flow direction.
The cleaning module 12 in step S13 cleans the sample analysis module 11 within a second time period by using the cleaning solution with the second concentration, including:
the cleaning module 12 performs a second time of cleaning on the sample analysis module 11 within a second time period by using the cleaning solution with the second concentration and the second cleaning solution pressure and/or the second cleaning solution flow direction.
Specifically, when the cleaning solution with a corresponding concentration is used to clean the sample analysis module 11 within a corresponding time period, the number of times of cleaning, and/or the pressure of the cleaning solution, and/or the flow direction of the cleaning solution may be configured accordingly, so that the cleaning method can be more suitable for the pollutant removal operation after the corresponding sample analysis operation, thereby improving the cleaning effect of the cleaning method.
In one embodiment, the sample analysis module 11 is cleaned, comprising:
the cleaning-liquid-required path and the cleaning-liquid-unnecessary path in the sample analysis module 11 are determined based on the processing module 13.
The sample analysis module 11 controls the cleaning solution path to be opened and controls the cleaning solution path not to be closed.
The cleaning module 12 cleans the sample analysis module 11 by using the cleaning solution in the corresponding cleaning manner.
Specifically, when the sample analysis module 11 is cleaned, the cleaning solution path and the unnecessary cleaning solution path therein may be determined first, and the unnecessary cleaning solution path is closed and the necessary cleaning solution path is opened, and then the corresponding cleaning solution is injected into the sample analysis module 11 for cleaning, so as to reduce unnecessary pipelines through which the cleaning solution needs to pass, and improve the cleaning efficiency of the cleaning method.
In one embodiment, as shown in FIG. 1, the sample analyzer 10 further includes a contamination detection module 14.
After the step of cleaning the sample analysis module 11 based on the determined cleaning manner, the cleaning method further includes:
the contamination detection module 14 detects the contamination degree of the sample analysis module 11.
If the contamination level is greater than the first preset contamination level threshold, the step of executing the processing module 13 to determine the cleaning mode of the sample analysis module 11 and the subsequent steps are returned.
Specifically, after step S12 or step S13 is performed, the contamination detection module 14 may be used to identify and evaluate the contamination degree of the sample analysis module 11, so as to obtain an evaluation value of the corresponding contamination degree. The mode of identifying and evaluating the contamination degree by the contamination detection module 14 may be specifically based on detecting the contamination degree by the impedance detection component and/or the optical detection component to obtain a particle count value corresponding to the contamination, so as to obtain the contamination degree of the sample analysis module 11.
If the contamination degree is greater than the first preset contamination degree threshold, it may be determined that the current contamination degree of the sample analysis module 11 is still high and still needs to be cleaned, so that the step of determining the cleaning manner of the sample analysis module 11 by the processing module 13 in step S11, the subsequent step S12 or step S13, the subsequent step of detecting the contamination degree of the sample analysis module 11 by the contamination detection module 14, and the like may be returned to form a loop.
If the contamination level is less than or equal to the first preset contamination level threshold, it is determined that the current contamination level of the sample analysis module 11 is sufficiently low or zero, and the above cycle is skipped to end the cleaning.
Based on the above manner, the sample analysis module 11 can be ensured to be cleaned to a sufficiently low degree of contamination, and the cleaning effect of the cleaning method is improved.
Optionally, the processing module 13 determines a cleaning mode of the sample analysis module 11, including:
if the contamination degree is greater than the second preset contamination degree threshold, it is determined that the cleaning mode of the sample analysis module 11 is the first cleaning mode.
If the contamination degree is less than or equal to the second preset contamination degree threshold, the cleaning mode of the sample analysis module 11 is determined to be the second cleaning mode.
And the second preset pollution degree threshold value is greater than the first preset pollution degree threshold value.
Specifically, the first concentration is greater than the second concentration, and the first period of time is less than the second period of time, and based on the setting of the concentration and the period of time, the first cleaning mode has a characteristic of quick cleaning, and the second cleaning mode has a characteristic of stable cleaning.
Therefore, when the contamination level is greater than the second predetermined contamination level threshold, that is, the contamination level is relatively high, the sample analysis module 11 may be quickly cleaned by the first cleaning method, so as to quickly remove the contaminants, which are relatively easy to clean, in the sample analysis module 11.
When the contamination degree is less than or equal to the second preset contamination degree threshold, that is, the contamination degree is relatively low, the sample analysis module 11 may be stably cleaned in the second cleaning manner, so as to continuously wash the contaminants difficult to clean in the sample analysis module 11.
Based on the above manner, the first cleaning manner and the second cleaning manner can be used alternately, so that the sample analysis module 11 can be cleaned comprehensively, and the cleaning effect of the cleaning method can be improved.
Optionally, the cleaning mode further comprises a pre-cleaning mode; the determining, by the processing module 13 in step S11, the cleaning manner of the sample analysis module 11 may specifically include:
if the sample analysis module 11 is not cleaned after the sample analysis module 11 completes the sample analysis operation, the processing module 13 determines that the cleaning mode of the sample analysis module 11 is the pre-cleaning mode.
If the sample analysis module 11 is cleaned after the sample analysis module 11 completes the sample analysis operation, the processing module 13 determines that the cleaning manner of the sample analysis module 11 is the first cleaning manner or the second cleaning manner.
The cleaning method further comprises the following steps:
if the cleaning mode is determined to be the pre-cleaning mode, the cleaning module 12 cleans the sample analysis module 11 within a third time period.
Wherein the third duration is associated with a sample analysis job.
Specifically, when the step of determining the cleaning manner of the sample analysis module 11 by the processing module 13 is executed, if the sample analysis module 11 has not been cleaned after completing the sample analysis operation, the cleaning manner may be determined as a pre-cleaning manner, and when the cleaning manner is determined as the pre-cleaning manner, the cleaning module 12 may clean the sample analysis module 11 for a third time period. The third duration may be determined by at least one of the sample, the sample usage amount, the analysis duration, and the like of the sample analysis operation, and the third duration is less than the first duration and less than the second duration.
When the step of determining the cleaning manner of the sample analysis module 11 by the processing module 13 is executed, if the sample analysis module 11 has already been cleaned in the pre-cleaning manner, the first cleaning manner, or the second cleaning manner after completing the sample analysis operation, the processing module 13 may determine that the cleaning manner of the sample analysis module 11 is the first cleaning manner or the second cleaning manner, and perform cleaning according to the corresponding cleaning manner.
Based on the above manner, the cleaning manner corresponding to the first cleaning of the sample analysis module 11 can be determined as the pre-cleaning manner, and different sample analysis operations correspond to different third durations, so that the rationality of the pre-cleaning manner is improved, the pertinence of the cleaning method to different sample analysis operations is further improved, and the cleaning effect of the cleaning method is improved.
The present application also provides a sample analyzer, referring to fig. 3, fig. 3 is a schematic structural diagram of another embodiment of the sample analyzer of the present application, and as shown in fig. 3, the sample analyzer 20 includes a sample analysis module 21, a cleaning module 22 and a processing module 23.
The processing module 23 is configured to determine a cleaning manner of the sample analysis module 21 after the sample analysis module 21 completes sample analysis operation, and control the cleaning module 22 to clean the sample analysis module 21 based on the determined cleaning manner.
The cleaning module 22 is used for: if the cleaning mode is determined to be the first cleaning mode, the sample analysis module 21 is cleaned within a first time period by using the cleaning solution with the first concentration. If the cleaning mode is determined to be the second cleaning mode, cleaning solution with the second concentration is adopted to clean the sample analysis module 21 within the second time period.
Wherein the first concentration is greater than the second concentration, and/or the first duration is less than the second duration.
Different from the prior art, in the technical scheme of the application, after the sample analysis module completes the sample analysis operation, the processing module can be adopted to determine the cleaning mode of the sample analysis module, and the cleaning mode can be determined to be a first cleaning mode or a second cleaning mode, wherein the first cleaning mode is higher in concentration of the adopted cleaning liquid and/or shorter in cleaning time compared with the second cleaning mode. Based on the above mode, the accessible sets up two kinds of cleaning methods of first cleaning method and second cleaning method, and two kinds of cleaning methods are different and have corresponding application condition respectively, can select one kind of cleaning method that wherein is more suitable to wash sample analyzer through processing module to avoid adopting the too high or long too long cleaning method of washing time of washing liquid concentration to wash and increase unnecessary cost sample analyzer, reduced the cleaning cost under the prerequisite of guaranteeing the cleaning performance.
The present application further provides a control device of a sample analyzer, referring to fig. 4, fig. 4 is a schematic structural diagram of an embodiment of the control device of the sample analyzer of the present application, and as shown in fig. 4, the control device 30 includes a processing module 31.
The processing module 31 is configured to: after a sample analysis module of the sample analyzer completes sample analysis operation, determining a cleaning mode of the sample analysis module, and controlling the cleaning module of the sample analyzer to clean the sample analysis module based on the determined cleaning mode. And if the cleaning mode is determined to be the first cleaning mode, controlling a cleaning module of the sample analyzer to clean the sample analysis module within a first time period by adopting the cleaning liquid with the first concentration. And if the cleaning mode is determined to be the second cleaning mode, controlling the cleaning module to adopt the cleaning solution with the second concentration to clean the sample analysis module within the second time period.
Wherein the first concentration is greater than the second concentration, and/or the first duration is less than the second duration.
Different from the prior art, in the technical scheme of the application, after the sample analysis module completes the sample analysis operation, the processing module can be adopted to determine the cleaning mode of the sample analysis module, and the cleaning mode can be determined to be a first cleaning mode or a second cleaning mode, wherein the first cleaning mode is higher in concentration of the adopted cleaning liquid and/or shorter in cleaning time compared with the second cleaning mode. Based on the above mode, the accessible sets up two kinds of cleaning methods of first cleaning method and second cleaning method, and two kinds of cleaning methods are different and have corresponding application condition respectively, can select one kind of cleaning method that wherein is more suitable to wash sample analyzer through processing module to avoid adopting the too high or long too long cleaning method of washing time of washing liquid concentration to wash and increase unnecessary cost sample analyzer, reduced the cleaning cost under the prerequisite of guaranteeing the cleaning performance.
In the description of the present application, reference to the description of the terms "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present application. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present application, "plurality" means at least two, e.g., two, three, etc., unless explicitly specified otherwise.
Any process or method descriptions in flow charts or otherwise described herein may be understood as representing modules, segments, or portions of code which include one or more executable instructions for implementing specific logical functions or steps in the process, and alternate implementations are included within the scope of the preferred embodiment of the present application in which functions may be executed out of order from that shown or discussed, including substantially concurrently or in reverse order, depending on the functionality involved, as would be understood by those reasonably skilled in the art of the present application.
The logic and/or steps represented in the flowcharts or otherwise described herein, such as an ordered listing of executable instructions that can be viewed as implementing logical functions, can be embodied in any computer-readable medium for use by or in connection with an instruction execution system, apparatus, or device (e.g., a personal computer, server, network device, or other system that can fetch the instructions from the instruction execution system, apparatus, or device and execute the instructions). For the purposes of this description, a "computer-readable medium" can be any means that can contain, store, communicate, propagate, or transport the program for use by or in connection with the instruction execution system, apparatus, or device. More specific examples (a non-exhaustive list) of the computer-readable medium would include the following: an electrical connection (electronic device) having one or more wires, a portable computer diskette (magnetic device), a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber device, and a portable compact disc read-only memory (CDROM). Further, the computer-readable medium could even be paper or another suitable medium upon which the program is printed, as the program can be electronically captured, via for instance optical scanning of the paper or other medium, then compiled, interpreted or otherwise processed in a suitable manner if necessary, and then stored in a computer memory.
The above description is only for the purpose of illustrating embodiments of the present application and is not intended to limit the scope of the present application, and all modifications of equivalent structures and equivalent processes, which are made by the contents of the specification and the drawings of the present application or are directly or indirectly applied to other related technical fields, are also included in the scope of the present application.
Claims (13)
1. A method for cleaning a sample analyzer, wherein the sample analyzer comprises a sample analysis module, a cleaning module and a processing module;
the cleaning method comprises the following steps:
after the sample analysis module completes sample analysis operation, the processing module determines a cleaning mode of the sample analysis module, and cleans the sample analysis module based on the determined cleaning mode: if the cleaning mode is determined to be the first cleaning mode, the cleaning module adopts cleaning liquid with the first concentration to clean the sample analysis module within a first time period; if the cleaning mode is determined to be a second cleaning mode, the cleaning module adopts the cleaning solution with a second concentration to clean the sample analysis module within a second time period;
wherein the first duration is less than the second duration; or the first concentration is greater than the second concentration and the first time period is less than the second time period;
the cleaning module adopts the cleaning solution with the second concentration to clean the sample analysis module within the second time period, and the method comprises the following steps:
the cleaning module injects the cleaning solution with the second concentration into a path of the sample analysis module needing cleaning solution;
the cleaning module oscillates the cleaning liquid with the second concentration in the liquid path to be cleaned, and the cleaning module enables the liquid path to be cleaned to be soaked in the cleaning liquid with the second concentration for a preset soaking time; or the cleaning module oscillates the cleaning liquid with the second concentration in the liquid path to be cleaned;
the cleaning module discharges the liquid in the liquid path to be cleaned;
the oscillating of the cleaning solution of the second concentration in the solution path to be cleaned by the cleaning module includes:
determining a target number based on the second concentration, the target number having a negative correlation with the second concentration;
and the cleaning module oscillates the cleaning liquid with the second concentration in the liquid path to be cleaned until the oscillation times reach the target times.
2. The cleaning method of claim 1, wherein the cleaning solution comprises a cleaning reagent and/or a diluting reagent, wherein the cleaning reagent is different from the diluting reagent;
the first concentration is the concentration of the cleaning reagent or the diluting reagent in the cleaning solution used in the first cleaning mode, and the second concentration is the concentration of the cleaning reagent or the diluting reagent in the cleaning solution used in the second cleaning mode.
3. The cleaning method of claim 1, wherein the cleaning module oscillates the cleaning solution in the path of the solution to be cleaned at the second concentration, comprising:
the cleaning module oscillates the cleaning liquid with the second concentration in the liquid path to be cleaned, and bubbles are introduced into the liquid path to be cleaned when the oscillation is performed and/or after the oscillation is performed.
4. The cleaning method according to claim 3, wherein the introducing of the bubbles into the liquid path to be cleaned comprises:
and introducing bubbles into the path of the liquid to be cleaned and injecting a surface active reagent.
5. The washing method according to claim 2, wherein the sample analysis module comprises a blood routine module for classifying and/or counting blood cells in the sample and a specific protein detection module for detecting a specific protein in the sample;
the cleaning the sample analysis module comprises:
repeatedly executing the steps of cleaning the blood routine module by the cleaning module by using the cleaning solution in a corresponding cleaning mode and cleaning the specific protein detection module by using a target cleaning solution until the repeated execution times reach a preset repeated times, wherein the target cleaning solution is the cleaning solution taking the liquid discharged after cleaning the blood routine module as the diluting reagent;
and the cleaning module is used for cleaning the specific protein detection module by adopting the cleaning solution in a corresponding cleaning mode.
6. The cleaning method of claim 1 or 2, wherein the sample analyzer further comprises a contamination detection module;
after the cleaning the sample analysis module based on the determined cleaning manner, the cleaning method further includes:
the pollution detection module detects the pollution degree of the sample analysis module;
and if the pollution degree is greater than a first preset pollution degree threshold value, returning to the step of executing the processing module to determine the cleaning mode of the sample analysis module and the subsequent steps.
7. The washing method of claim 6, wherein the processing module determines a washing pattern of the sample analysis module, comprising:
if the pollution degree is greater than a second preset pollution degree threshold value, determining that the cleaning mode of the sample analysis module is a first cleaning mode;
if the pollution degree is less than or equal to the second preset pollution degree threshold value, determining that the cleaning mode of the sample analysis module is a second cleaning mode;
wherein the second preset pollution degree threshold is greater than the first preset pollution degree threshold.
8. The cleaning method according to claim 6, wherein the detecting the degree of contamination by the contamination detecting module comprises:
the contamination detection module detects the contamination level based on an impedance detection component and/or an optical detection component.
9. The cleaning method according to claim 6, wherein the cleaning mode further comprises a pre-cleaning mode;
the processing module determining a manner of cleaning of the sample analysis module, comprising:
if the sample analysis module is not cleaned after the sample analysis module completes the sample analysis operation, the processing module determines that the cleaning mode of the sample analysis module is a pre-cleaning mode;
if the sample analysis module is cleaned after the sample analysis module completes the sample analysis operation, the processing module determines that the cleaning mode of the sample analysis module is the first cleaning mode or the second cleaning mode;
the cleaning method further comprises the following steps:
if the cleaning mode is determined to be the pre-cleaning mode, the cleaning module cleans the sample analysis module within a third time period;
wherein the third duration is associated with the sample analysis job.
10. The cleaning method of claim 1 or 2, wherein the cleaning module cleans the sample analysis module with a cleaning solution of a first concentration for a first duration, comprising:
the cleaning module adopts cleaning liquid with a first concentration, and cleans the sample analysis module for a first time within a first time length by the pressure and/or the flow direction of the first cleaning liquid;
the cleaning module adopts the cleaning solution with the second concentration to clean the sample analysis module within the second time period, and the method comprises the following steps:
and the cleaning module adopts the cleaning solution with the second concentration, and cleans the sample analysis module for a second time within a second time length according to the pressure and/or the flow direction of the second cleaning solution.
11. The cleaning method according to claim 1 or 2, wherein the cleaning the sample analysis module comprises:
determining a cleaning solution required path and a cleaning solution not required path in the sample analysis module based on the processing module;
the sample analysis module controls the cleaning solution path to be opened and controls the cleaning solution path not to be closed;
and the cleaning module is used for cleaning the sample analysis module by adopting the cleaning solution in a corresponding cleaning mode.
12. A sample analyzer is characterized by comprising a sample analysis module, a cleaning module and a processing module;
the processing module is used for determining a cleaning mode of the sample analysis module after the sample analysis module finishes sample analysis operation, and controlling the cleaning module to clean the sample analysis module based on the determined cleaning mode;
the cleaning module is used for: if the cleaning mode is determined to be the first cleaning mode, cleaning the sample analysis module by adopting a cleaning solution with a first concentration within a first time length; if the cleaning mode is determined to be a second cleaning mode, cleaning the sample analysis module by adopting the cleaning solution with a second concentration within a second time period;
wherein the first duration is less than the second duration; or, the first concentration is greater than the second concentration and the first duration is less than the second duration;
the cleaning solution with the second concentration is used for cleaning the sample analysis module within a second time period, and the method comprises the following steps:
injecting the cleaning solution with the second concentration into a path of the sample analysis module needing cleaning solution;
oscillating the cleaning liquid with the second concentration in the liquid path to be cleaned, so that the liquid path to be cleaned is soaked in the cleaning liquid with the second concentration for a preset soaking time; or oscillating the cleaning liquid with the second concentration in the liquid path to be cleaned;
discharging the liquid in the liquid path to be cleaned;
the oscillating the cleaning solution of the second concentration in the solution path to be cleaned includes:
determining a target number based on the second concentration, the target number having a negative correlation with the second concentration;
and oscillating the cleaning liquid with the second concentration in the liquid path to be cleaned until the oscillation times reach the target times.
13. A control device of a sample analyzer is characterized by comprising a processing module;
the processing module is used for:
after a sample analysis module of the sample analyzer completes sample analysis operation, determining a cleaning mode of the sample analysis module, and controlling the cleaning module of the sample analyzer to clean the sample analysis module based on the determined cleaning mode;
if the cleaning mode is determined to be the first cleaning mode, controlling the cleaning module to adopt cleaning liquid with the first concentration to clean the sample analysis module within a first time period; if the cleaning mode is determined to be a second cleaning mode, controlling the cleaning module to adopt the cleaning liquid with a second concentration to clean the sample analysis module within a second time period;
wherein the first duration is less than the second duration; or the first concentration is greater than the second concentration and the first time period is less than the second time period;
the step of controlling the cleaning module to adopt the cleaning solution with the second concentration to clean the sample analysis module within the second time period comprises the following steps:
controlling the cleaning module to inject the cleaning solution with the second concentration into a path of the sample analysis module needing cleaning solution;
controlling the cleaning module to oscillate the cleaning liquid with the second concentration in the liquid path to be cleaned, and controlling the cleaning module to enable the liquid path to be cleaned to be soaked in the cleaning liquid with the second concentration for a preset soaking time; or controlling the cleaning module to oscillate the cleaning liquid with the second concentration in the liquid path to be cleaned;
controlling the cleaning module to discharge the liquid in the liquid path to be cleaned;
the controlling the cleaning module to oscillate the cleaning solution of the second concentration in the solution path to be cleaned includes:
determining a target number based on the second concentration, the target number having a negative correlation with the second concentration;
and controlling the cleaning module to oscillate the cleaning liquid with the second concentration in the liquid path to be cleaned until the oscillation frequency reaches the target frequency.
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