JP5443775B2 - Automatic analyzer and automatic analysis method - Google Patents

Description

  The present invention relates to an automatic analyzer and an automatic analysis method, and in particular, samples a test solution of blood or urine to determine the concentration or activity value of a component contained in the test solution and to perform a chemical reaction with a test reagent. The present invention relates to an analysis apparatus and an automatic analysis method that use optical and electrical measurements.

  In a conventional automatic analyzer, after sampling the test liquid and measuring the test liquid, the part contaminated with the test liquid is washed, and carryover does not affect the measurement data of the next test liquid I am doing so. In order to avoid the influence of carry-over, there is a method of changing the cleaning conditions (the number of cleanings and the cleaning time) based on the number of samplings and the sampling amount (for example, Patent Document 1). In addition, the type of test liquid (serum, urine) is registered in advance as a measurement parameter, and according to the type of test liquid, for example, when the test liquid is serum, the number of times of washing is one. In the case of urine, a method of changing the number of washings to two is also conceivable.

JP 2007-225608 A

  However, in the automatic analyzer described in the above-mentioned patent document, when a test liquid having an abnormal concentration (for example, a urine sample of a serious patient) is sampled once, the test liquid can be sufficiently washed. Carryover occurs. Then, the measurement data of the next test solution is affected by the carryover.

  Further, in the above method of changing the cleaning conditions according to the type of the test liquid, for example, when the user incorrectly sets the type of the test liquid, similarly, the test liquid cannot be sufficiently cleaned, There was a problem that carry-over occurred.

  The present invention solves the above-described problems, and provides an automatic analyzer and an automatic analysis method that can sufficiently wash a test solution in an electrode section and reliably avoid the effects of carryover. With the goal.

In order to solve the above problems, the present invention focuses on determining whether or not the inside of the electrode section is affected by carryover every time the test liquid is introduced into the electrode section.
Specifically, in the first embodiment of the present invention, the electrode potential of the test liquid introduced into the electrode part is measured, and after the test liquid is discharged from the electrode part, the calibration liquid introduced into the electrode part is measured. An automatic analyzer that measures the electrode potential and measures the electrolyte concentration of the test solution based on the electrode potentials of the calibration solution and the test solution, and introduces the test solution into the electrode part, During the period until the introduced test solution is discharged from the electrode unit, a measuring unit that measures the electrode potential of the test solution only a predetermined number of times, and the test that is measured only the predetermined number of times A determination unit for determining whether or not the amount of change in the electrode potential of the test liquid each time determined based on the electrode potential of the liquid exceeds a predetermined value; and cleaning the inside of the electrode unit in a predetermined manner a cleaning unit, one of the variation of the electrode potential of the test solution of the each time is pre to When the determination unit determines that a predetermined value has been exceeded, a control unit that causes the cleaning unit to clean the inside of the electrode unit in a predetermined manner before introducing the next test solution, It is an automatic analyzer characterized by having.
Further, the second aspect of the present invention includes a test liquid suction step for sucking a test liquid into the electrode part by a probe , introducing the test liquid into the electrode part, and introducing the introduced test liquid into the electrode part. Based on the test liquid measurement step of measuring the electrode potential of the test liquid only a predetermined number of times during the period until discharging from the electrode section, and the electrode potential of the test liquid measured only the predetermined time If any of the change amounts of the electrode potential of the test solution each time required exceeds a predetermined value, before introducing the next test solution, the inside of the electrode portion in a predetermined manner. And a step for washing .

  According to this invention, it is possible to reliably avoid the influence of carry-over by thoroughly washing the inside of the electrode part before introducing the next test solution.

  Further, according to the first embodiment of the present invention, the test liquid has an abnormal concentration or the type of the test liquid is misidentified from the potential difference between the electrode potential of the test liquid and the calibration liquid. It becomes possible to judge. Therefore, based on the potential difference between the electrode potential of the test solution and the electrode potential of the calibration solution, the control unit can cause the cleaning unit to sufficiently clean the inside of the electrode unit.

  Furthermore, according to the second aspect of the present invention, it can be determined from the electrode potential of the test solution that the electrolyte concentration of the test solution has exceeded the value assumed by the user.

  Furthermore, according to the third aspect of the present invention, it can be determined from the electrode potential of the calibration liquid that the electrolyte concentration of the calibration liquid has exceeded the value assumed by the user.

  Furthermore, according to the fourth aspect of the present invention, it is possible to determine from the change in the electrode potential of the test liquid that the electrolyte concentration of the test liquid exceeds the value assumed by the user.

  Further, according to the sixth embodiment of the present invention, the control unit performs the calibration liquid suction / discharge operation a predetermined number of times in the cleaning unit based on the potential difference between the electrode potential of the test solution and the electrode potential of the calibration solution. Since the process is repeated, the inside of the electrode part can be sufficiently cleaned. Further, as a predetermined mode for cleaning the inside of the electrode part, since the calibration liquid suction / discharge operation when measuring the electrolyte concentration of the test liquid is used, it is not necessary to provide a special means for cleaning the inside of the electrode part. .

It is a figure explaining the structure of the automatic analyzer which concerns on 1st Embodiment of this invention. It is a functional block diagram of an automatic analyzer. It is a time chart which shows the suction / discharge operation of the test liquid and the calibration liquid and the electrode potential of the test liquid in association with each other. It is a flowchart which shows operation | movement of an automatic analyzer. In 2nd Embodiment of this invention, it is a time chart figure which shows the suction / discharge operation | movement of a test liquid and a calibration liquid, and the electrode potential of a test liquid, etc. correspondingly. In 3rd Embodiment of this invention, it is a time chart figure which shows the suction / discharge operation | movement of a test liquid and a calibration liquid, the electrode potential of a test liquid, etc. correspondingly. In 4th Embodiment of this invention, it is a time chart figure which shows the suction / discharge operation | movement of a test liquid and a calibration liquid, the electrode potential of a test liquid, etc. correspondingly.

[First Embodiment]
(Constitution)
The configuration of the automatic analyzer according to the first embodiment of the present invention will be described with reference to FIG. 1 and FIG. FIG. 1 is a block diagram conceptually showing each configuration of the automatic analyzer, and FIG. 2 is a functional block diagram of the automatic analyzer.

  Using this automatic analyzer, the test solution and calibration solution are alternately sucked, the electrode potentials of the sucked test solution and calibration solution are measured, and the concentration or activity of the components contained in the test solution is measured. Measure the value.

  First, the control unit 31 controls the operation of the switching valve (not shown) and the operation of the pump 10. By operating the pump 10, the inside of the probe 11 becomes negative pressure, and the probe 11 sucks a predetermined amount of the test liquid from the reaction cell 12. The sucked test liquid flows into the electrode sensor 20 (electrode part) through the tube. In the electrode sensor 20, an ion selective electrode 21 that selectively responds to each electrolyte such as sodium ion, potassium ion, and chlorine ion contained in the test solution, and a reference electrode 22 that serves as a reference for this electrode are provided. It has been.

  The control unit 31 obtains the concentration of the electrolyte in the test solution based on the electromotive force between the ion selective electrode 21, the reference electrode 22, and the electrode. The ion-selective electrode 21 and the reference electrode 22 are used by being mounted on an automatic analyzer for analyzing components such as biochemical test items and immunological test items contained in the test solution, or a device dedicated to measuring an electrolyte.

  In this ion selective electrode 21, the potential of the sensitive membrane constituted by a component containing a sensitive substance that selectively responds to specific ions contained in the test solution is output to the output pin via the internal electrode. . The reference electrode 22 outputs a constant potential generated with respect to the test solution to the output pin via the internal electrode. Then, by measuring an electromotive force that is a potential difference between the ion selective electrode 21 and the reference electrode 22, the concentration of the specific ion can be obtained.

  The control unit 31 controls the operation of the switching valve (not shown) and the operation of the pump 10. By operating the pump 10, the inside of the probe 11 becomes negative pressure, and the probe 11 sucks a predetermined amount of calibration liquid from the calibration liquid cup 13. Further, the suctioned calibration solution flows through the tube into the ion selective electrode 21 and the reference electrode 22 in the electrode sensor 20. By operating the pump 10, the calibration liquid is sent out from the calibration liquid bottle 15 through the tube to the calibration liquid cup 13. Further, the test liquid is discharged from the electrode sensor 20 to the waste liquid bottle 16 with the suction of the calibration liquid.

  Further, by the operation of the pump 10, the reference electrode internal liquid is pushed out from the reference electrode internal liquid bottle 14 and flows into the reference electrode 22 through the tube, where it merges with the test liquid or the calibration liquid.

  When the test solution fills the ion selective electrode 21 and the reference electrode 22, the operation of the pump 10 is temporarily stopped. The electrometer 23 measures the potential generated at the ion selective electrode 21 and outputs it as digital data to the control unit 31. The electrometer 23 measures the potential generated at the reference electrode 22 and outputs it as digital data to the control unit 31. The control unit 31 stores the data of these two potentials in the internal memory. The potential difference calculation unit 33 calculates the potential difference between these two potentials. FIG. 2 shows a potential difference calculation unit 33 that calculates a potential difference between two potentials. The control unit 31 stores the potential difference between the two potentials in the internal memory. A storage unit 36 which is an internal memory is shown in FIG.

  The potential difference between the two potentials (the potential difference between the potential generated at the ion selective electrode 21 and the potential generated at the reference electrode 22) corresponds to the electrode potential of the test solution.

  On the other hand, when the calibration solution fills the ion selective electrode 21 and the reference electrode 22, the operation of the pump 10 is temporarily stopped. The electrometer 23 measures the potential generated at the ion selective electrode 21 and outputs it as digital data to the control unit 31. The electrometer 23 measures the potential generated at the reference electrode 22 and outputs it as digital data to the control unit 31. The control unit 31 stores the data of these two potentials in the internal memory. The potential difference calculation unit 33 calculates the potential difference between these two potentials. The control unit 31 stores the potential difference between the two potentials in the internal memory.

  The potential difference between the two potentials (the potential difference between the potential generated at the ion selective electrode 21 and the potential generated at the reference electrode 22) corresponds to the electrode potential of the calibration liquid.

  Further, the potential difference calculating unit 33 obtains the potential difference between the electrode potential of the test solution and the electrode potential of the calibration solution, and the electrolyte concentration calculating unit 34 refers to the electrolyte concentration correspondence table 37 on the basis of the potential difference, and the test solution. Calculate the electrolyte concentration. The electrolyte concentration correspondence table 37 is a table showing the correspondence between the electrode potential of the test solution and the potential difference of the calibration solution and the electrolyte concentration of the test solution.

  As described above, the control unit 31 measures the electrode potential of the test liquid by sucking the test liquid into the electrode sensor 20 by controlling the operation of the switching valve and the operation of the pump 10.

  In addition, the control unit 31 controls the operation of the switching valve and the operation of the pump 10 to suck the calibration liquid into the electrode sensor 20 and then discharge the calibration liquid to determine the inside of the electrode sensor 20 in advance. Wash under specified conditions. The pump 10 and the switching valve correspond to a cleaning unit.

  In the automatic analyzer, the first cleaning condition is that the potential difference between the electrode potential of the test solution and the electrode potential of the calibration solution exceeds a predetermined value, and the determination unit determines that the first cleaning condition is satisfied. When 32 is judged, the control part 31 was made to wash | clean the inside of the electrode sensor 20 in the aspect predetermined by the washing | cleaning part. Specifically, the determination unit 32 is a predetermined value stored in the storage unit 36 and the potential difference between the electrode potential of the test solution and the electrode potential of the calibration solution stored in the storage unit 36 which is an internal memory. The potential difference of the test solution is compared. In response to the comparison result from the determination unit 32, the control unit 31 causes the cleaning unit to perform cleaning when the determination result satisfies the first cleaning condition.

  Next, a predetermined mode for cleaning the inside of the electrode sensor 20 will be described with reference to FIGS. FIG. 3 is a time chart showing the operation of sucking and discharging the test solution and the calibration solution.

  The control unit 31 controls the operation of the switching valve and the operation of the pump 10, and operates after the suction of the test liquid into the electrode sensor 20 until the suctioned test liquid is discharged from the electrode sensor 20 (the test target). After the suction / discharge operation of the test solution), the inside of the electrode sensor 20 is cleaned.

  The predetermined mode of cleaning the inside of the electrode sensor 20 is an operation from the time when the calibration liquid is sucked into the electrode sensor 20 until the suctioned calibration liquid is discharged from the electrode sensor 20 to the waste liquid bottle 16 (the flow of the calibration liquid). This is a mode in which the suction / discharge operation) is repeated a predetermined number of times. In accordance with the potential difference between the electrode potential of the test solution and the electrode potential of the calibration solution, the number of times the calibration solution is sucked and discharged is determined in advance. As a predetermined mode for cleaning the inside of the electrode sensor 20, the calibration liquid suction / discharge operation (original suction / discharge operation) for measuring the electrolyte concentration of the test solution is used, so that the electrode sensor 20 is cleaned. There is no need to provide special means. FIG. 3 shows a mode in which the calibration liquid suction / discharge operation is repeated twice after the test liquid suction / discharge operation (original suction / discharge operation and new calibration liquid suction / discharge operation).

  The predetermined mode for cleaning the inside of the electrode sensor 20 is a mode in which the operation of sucking the cleaning agent into the electrode sensor 20 and then discharging the cleaning agent from the electrode sensor 20 is repeated a predetermined number of times. Also good. A cleaning agent cup 17 is shown in FIG.

(Operation)
Next, the operation of this automatic analyzer will be described with reference to FIG. FIG. 4 is a flowchart showing the operation of the automatic analyzer.

  First, the determination unit 32 determines whether or not the measurement of the electrode potentials of all the test liquids has been completed (step S01). When the determination unit 32 determines that the measurement of the electrode potentials of all the test liquids is not completed (step S01; No), the control unit 31 controls the operation of the switching valve and the operation of the pump 10, and the probe 11 Thus, the test liquid is sucked into the electrode sensor 20 (test liquid suction step S02).

  The electrometer 23 measures two potentials, ie, a potential generated at the ion selective electrode 21 and a potential generated at the reference electrode 22. The control unit 31 measures the electrode potential (A) of the test liquid based on the potential difference between the two potentials (test liquid measurement step S03).

  After the test liquid measurement step S03, the control unit 31 controls the operation of the switching valve and the operation of the pump 10, discharges the test liquid from the electrode sensor 20, and responds to the discharge of the test liquid. 11, the calibration liquid is sucked into the electrode sensor 20 (calibration liquid suction step S04).

  The electrometer 23 measures two potentials, ie, a potential generated at the ion selective electrode 21 and a potential generated at the reference electrode 22. The controller 31 measures the electrode potential (B) of the calibration liquid based on the potential difference between the two potentials (calibration liquid measurement step S05).

  Next, the control unit 31 calculates a potential difference (A−B) between the electrode potential of the test solution and the electrode potential of the calibration solution (step S06). After step S06, the determination unit 32 determines whether or not the potential difference (A−B) exceeds a predetermined value (C> A−B?) (Step S07). Steps S06 to 07 may be performed as follows. Based on the potential difference (A−B) between the electrode potential of the test solution and the calibration solution, the electrolyte concentration of the test solution is calculated (step S06), and the electrolyte concentration of the test solution is set to a predetermined value. Judgment part 32 judges whether it has exceeded (Step S07). In step S06 in this case, as described above, the electrolyte concentration of the test solution is determined based on the potential difference (A−B) between the electrode potential of the test solution and the electrode potential of the calibration solution. Calculate by reference.

  When the determination unit 32 determines that the potential difference (A−B) does not exceed a predetermined value (step S07; No), it controls whether or not the measurement of the electrode potentials of all the test liquids has been completed. It returns to step S01 which the part 31 judges.

  On the other hand, when the determination unit 32 determines that the potential difference (A−B) exceeds a predetermined value (step S07; Yes), the control unit 31 controls the operation of the switching valve and the operation of the pump 10. Then, the inside of the electrode sensor 20 is cleaned in a predetermined manner (step S08). Thereafter, the process returns to step S01 in which the control unit 31 determines whether or not the measurement of the electrode potentials of all the test solutions has been completed. Since the inside of the electrode sensor 20 is cleaned in a predetermined manner, it is possible to avoid the effect of carryover.

  The predetermined mode is a mode in which the calibration liquid suction / discharge operation is repeated a predetermined number of times as described above. After the inside of the electrode sensor 20 is cleaned in the predetermined mode, the control unit 31 returns to step S01 in which it is determined whether or not the measurement of the electrode potentials of all the test liquids has been completed.

  In the above embodiment, the pump 10 and the probe 11 are used to suck the test liquid into the electrode sensor 20 and the calibration liquid into the electrode sensor 20, but the present invention is not limited to this. What is necessary is just to introduce a test liquid and a calibration liquid into the electrode sensor 20.

  Although the present invention is applied to an automatic analyzer that electrically measures the concentration of a component of a test liquid, the present invention is applied to an automatic analyzer that optically measures the concentration of a component of a test liquid. It may be applied.

[Second Embodiment]
Next, an automatic analyzer according to a second embodiment of the present invention will be described with reference to FIGS. FIG. 5 is a time chart showing the suction and discharge operations of the test solution and the calibration solution in correspondence with the electrode potential of the test solution and the like.

  In the automatic analyzer according to the second embodiment, the second cleaning condition is that the electrode potential of the test solution exceeds a predetermined value, and the determination unit determines that the second cleaning condition is satisfied. In this case, the control unit cleans the inside of the electrode sensor 20 in a manner predetermined by the cleaning unit. Specifically, the determination unit 32 compares the electrode potential of the test solution stored in the storage unit 36 with a predetermined electrode potential difference of the test solution stored in the storage unit 36 (FIG. 4). Equivalent to step S07). In response to the comparison result from the determination unit 32, the control unit 31 causes the cleaning unit to perform cleaning when the comparison result satisfies the second cleaning condition. In the second embodiment, the operation of the automatic analyzer is different from that of the first embodiment in the operation of step S07 shown in FIG. Since the electrode potential of the test solution shows a high value exceeding a predetermined value, it is possible to avoid the predicted carryover effect.

  In the second embodiment, the predetermined mode is a mode in which the calibration liquid suction / discharge operation is repeated a predetermined number of times according to the electrode potential of the test liquid. FIG. 5 shows a mode in which the calibration liquid suction / discharge operation is repeated twice after the test liquid suction / discharge operation.

[Third Embodiment]
Next, an automatic analyzer according to a third embodiment of the present invention will be described with reference to FIGS. FIG. 6 is a time chart showing the suction / discharge operation of the test solution and the calibration solution in correspondence with the electrode potential of the test solution and the like.

  In the automatic analyzer according to the third embodiment, when the determination unit determines that the electrode potential of the calibration solution exceeds a predetermined value, the control unit sets the electrode sensor in a predetermined manner in the cleaning unit. 20 was cleaned.

  Here, for example, it is determined that the third cleaning condition is satisfied when the electrode potential of the calibration liquid sucked before sucking the next test liquid exceeds a predetermined value, and the third cleaning condition is satisfied. When the unit determines, the control unit cleans the inside of the electrode sensor 20 in a manner predetermined by the cleaning unit. Specifically, the determination unit 32 compares the electrode potential of the calibration solution stored in the storage unit 36 with the electrode potential difference of the predetermined calibration solution stored in the storage unit 36 (shown in FIG. 4). Equivalent to step S07). In response to the comparison result from the determination unit 32, the control unit 31 causes the cleaning unit to perform cleaning when the comparison result satisfies the second cleaning condition. In the third embodiment, the operation of the automatic analyzer is different from that of the first embodiment in the operation of step S07 shown in FIG. Thereby, for example, when the electrode potential of the calibration liquid sucked into the electrode sensor 20 is gradually changed, it is possible to reliably avoid the influence of carryover.

  In addition, the potential difference between the electrode potentials of the calibration solution aspirated before aspirating the test fluid and the calibration fluid aspirated before aspirating the next test fluid exceeded a predetermined value. May be the third cleaning condition, and when the determination unit determines that the third cleaning condition is satisfied, the control unit may cause the cleaning unit to clean the inside of the electrode sensor 20 in a predetermined manner. Thereby, for example, when the electrode potential of the calibration liquid sucked into the electrode sensor 20 changes abruptly, it is possible to avoid a large influence of carryover.

  Furthermore, when the determination unit determines that both the third cleaning conditions are satisfied, the control unit may cause the cleaning unit to clean the inside of the electrode sensor 20 in a predetermined manner.

  In the third embodiment, the predetermined mode is a mode in which the calibration liquid suction / discharge operation is repeated a predetermined number of times according to the electrode potential of the calibration liquid. FIG. 6 shows a mode in which the calibration solution suction / discharge operation is repeated twice after the test solution suction / discharge operation (original suction / discharge operation and new calibration solution suction / discharge operation).

[Fourth Embodiment]
Next, an automatic analyzer according to a fourth embodiment of the present invention will be described with reference to FIGS. FIG. 7 is a time chart showing the suction / discharge operation of the test solution and the calibration solution and the change in the electrode potential of the test solution in correspondence with each other.

  In the automatic analyzer according to the fourth embodiment, the fourth cleaning condition is that the change in the electrode potential of the test solution exceeds a predetermined value, and the determination unit determines that the fourth cleaning condition is satisfied. When the determination is made, the control unit causes the cleaning unit to clean the inside of the electrode sensor 20 in a predetermined manner. FIG. 2 shows a potential change calculation unit 35 for calculating the difference between the electrode potential of the test liquid acquired at a predetermined time and the electrode potential of the test liquid acquired at the previous predetermined time. The control unit 31 causes the storage unit 36 to store the result calculated by the potential change calculation unit 35. The determination unit 32 reads the calculation result by the potential change calculation unit 35 stored in the storage unit 36 and compares it with a predetermined amount of change in the electrode potential of the test solution stored in the storage unit 36 (see FIG. 4). Equivalent to step S07 shown). In response to the comparison result by the determination unit 32, the control unit 31 causes the cleaning unit to perform cleaning when the comparison result satisfies the fourth cleaning condition. In the fourth embodiment, the operation of the automatic analyzer is different from that of the first embodiment in the operation of step S07 shown in FIG.

  During the period from when the test liquid is sucked into the electrode sensor 20 until it is discharged from the electrode sensor 20, the electrometer 23 calculates the potential generated at the ion selective electrode 21 and the potential generated at the reference electrode 22. Measured a predetermined number of times (for example, 80 points). The potential difference calculation unit 33 obtains the amount of change in the electrode potential of the test solution at each point based on the 80 points of measurement data. The determination unit 32 compares whether or not the amount of change in the electrode potential of the test solution exceeds a predetermined value at each point. The control unit 31 receives the comparison result by the determination unit 32, and when the comparison result at any point exceeds the predetermined value of the amount of change in the electrode potential of the test solution, in a predetermined mode. The inside of the electrode sensor 20 was cleaned. Since the electrode potential of the test solution at each point is obtained, it becomes possible to make a more accurate judgment on the effect of carryover.

  The control unit 31 cleans the inside of the electrode sensor 20 in a predetermined manner when the number of points where the amount of change in the electrode potential of the test solution exceeds a predetermined value exceeds a predetermined number. May be.

  Further, the determination unit 32 compares whether or not the difference between the minimum value and the maximum value of the electrode potential of the test solution exceeds a predetermined value, and the control unit 31 determines the comparison result by the determination unit 32. In response, when the comparison result exceeds a predetermined value, the inside of the electrode sensor 20 may be cleaned in a predetermined manner.

  The change in the electrode potential of the test solution obtained by the control unit 31 is indicated by a solid line in FIG. 7, and the assumed change in the electrode potential of the test solution is indicated by a two-point difference line in FIG.

  In the fourth embodiment, a predetermined mode is a mode in which the calibration liquid suction / discharge operation is repeated a predetermined number of times in accordance with the change in the electrode potential of the test liquid. FIG. 7 shows an aspect (the original suction / discharge operation and the new calibration solution suction / discharge operation) in which the calibration solution suction / discharge operation is repeated twice after the test solution suction / discharge operation.

  In each said embodiment, when the 1st-4th washing | cleaning conditions were satisfy | filled, the control part 31 showed what wash | cleans the inside of the electrode sensor 20 by the washing | cleaning part. Not limited to this, two or more cleaning conditions may be combined to form one or a plurality of new cleaning conditions. In this case, when the determination unit 32 determines that any one of a plurality of combined new cleaning conditions is satisfied, the control unit 31 may cause the cleaning unit to clean the inside of the electrode sensor 20. Further, when the determination unit 32 determines that all of the combined multiple new cleaning conditions are satisfied, the control unit 31 may cause the cleaning unit to clean the inside of the electrode sensor 20.

10 Pump 11 Probe 12 Reaction cell 13 Calibration liquid cup
14 Reference electrode internal liquid bottle 15 Calibration liquid bottle 16 Waste liquid bottle
17 Cleaning agent cup 20 Electrode sensor 21 Ion selective electrode
22 reference electrode 23 electrometer 31 control unit 32 determination unit 33 potential difference calculation unit 34 electrolyte concentration calculation unit 35 potential change calculation unit 36 storage unit 37 electrolyte concentration correspondence table

Claims (5)

The electrode potential of the test solution introduced into the electrode unit is measured, and after the test solution is discharged from the electrode unit, the electrode potential of the calibration solution introduced into the electrode unit is measured, and the calibration solution and the test solution are measured. An automatic analyzer that measures the electrolyte concentration of a test liquid based on each electrode potential of the liquid,
A measuring unit that introduces the test solution into the electrode unit and measures the electrode potential of the test solution only a predetermined number of times during a period until the introduced test solution is discharged from the electrode unit; ,
A determination unit that determines whether or not the amount of change in the electrode potential of the test solution obtained each time based on the electrode potential of the test solution measured only a plurality of times exceeds a predetermined value;
A cleaning unit for cleaning the inside of the electrode unit in a predetermined manner;
When the determination unit determines that any of the change amounts of the electrode potential of the test solution each time exceeds a predetermined value, before introducing the next test solution, the cleaning unit A control unit for cleaning the inside of the electrode unit in the predetermined mode;
The automatic analyzer characterized by having. The controller is
When the number of changes exceeding a predetermined value among a plurality of the change amounts obtained based on the electrode potential of the test solution measured only a predetermined number of times exceeds a predetermined number, the next test solution is 2. The automatic analyzer according to claim 1, wherein before the introduction, the inside of the electrode unit is cleaned in the predetermined manner by the cleaning unit. The determination unit
Determining whether the difference between the lowest value and the highest value exceeds a predetermined value;
The controller is
When the determination unit determines that the difference between the minimum value and the maximum value of the electrode potential of the test solution measured only a predetermined number of times exceeds a predetermined value, the next test solution is introduced. 2. The automatic analyzer according to claim 1, wherein the cleaning unit causes the cleaning unit to clean the inside of the electrode unit in a predetermined manner. Embodiment, said predetermined, wherein the calibration fluid is introduced into the electrode portion, claim 1, characterized in that it comprises a mode of repeating a predetermined number of times the operation for discharging the calibration solution that the introduction from the electrode portion Item 4. The automatic analyzer according to any one of Items 3 to 4 . A test liquid suction step for sucking the test liquid into the electrode part by a probe;
A test liquid that introduces the test liquid into the electrode part and measures the electrode potential of the test liquid only a predetermined number of times during the period until the introduced test liquid is discharged from the electrode part. A measurement step;
If any of the change amounts of the electrode potential of the test liquid obtained each time based on the electrode potential of the test liquid measured only a predetermined number of times exceeds a predetermined value, the next test Before introducing the liquid, washing the inside of the electrode portion in a predetermined manner;
An automatic analysis method characterized by comprising:

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