CN110749730B - Sample analysis device and cleaning method thereof - Google Patents
Sample analysis device and cleaning method thereof Download PDFInfo
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- CN110749730B CN110749730B CN201910667216.6A CN201910667216A CN110749730B CN 110749730 B CN110749730 B CN 110749730B CN 201910667216 A CN201910667216 A CN 201910667216A CN 110749730 B CN110749730 B CN 110749730B
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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Abstract
The application discloses a sample analysis device and a cleaning method thereof, wherein the device comprises the following components: the immunoassay sub-device further comprises a controller, wherein the controller is connected with the immunoassay sub-device and used for controlling the immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device when no sample to be detected exists, determining a cleaning mode of the immunoassay sub-device according to comparison between the first background voltage value and a preset background voltage threshold value and sending a corresponding cleaning instruction; and the cleaning subsystem is connected with the controller and is used for receiving the cleaning instruction sent by the controller and responding to the cleaning instruction to correspondingly clean the immunoassay sub-device. By the mode, the application can provide technical support for saving specific cleaning liquid and reducing the risk of pollution of the specific cleaning liquid on the basis of ensuring the cleaning effect, the detection precision of the device and the accuracy of the sample detection result.
Description
Technical Field
The application relates to the technical field of immunoassay, in particular to a sample analysis device and a cleaning method thereof.
Background
The immune analysis device performs emulsion immune reaction by utilizing an emulsion immune reaction reagent and a sample to be detected, and completes emulsion immune analysis by utilizing a laser scattering or transmission detection method. In order to facilitate maintenance and reuse of the immunoassay device, to extend the service cycle of the immunoassay device and to ensure reliability of the analysis result of the sample, it is generally necessary to clean the immunoassay device.
In the prior art, the immunoassay device is cleaned by using a blood conventional hemolytic agent or a test solution after blood conventional reaction, namely, the immunoassay device is cleaned after each latex immunoassay reaction and analysis. However, the inventors of the present application have found during long-term development that the above cleaning method has the following drawbacks: firstly, the consumption of the conventional hemolytic agent is increased, the cost is greatly increased, secondly, the conventional hemolytic agent has stronger hemolytic capability than the immune hemolytic agent, and the conventional hemolytic agent or the test solution after the conventional reaction of the blood is used for flushing each time, so that the risk of pollution to the emulsion immune agent is increased, and the result is unreliable.
Disclosure of Invention
The application mainly solves the technical problem of providing a sample analysis device and a cleaning method thereof, which can provide technical support for saving specific cleaning liquid and reducing the risk of pollution of the specific cleaning liquid on the basis of ensuring the cleaning effect, the detection precision of the device and the accuracy of a sample detection result.
In order to solve the technical problems, the application adopts a technical scheme that: there is provided a sample analysis device comprising an immunoassay sub-device, the device further comprising: the controller is connected with the immunoassay sub-device and is used for controlling the immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device when no sample to be detected exists, determining a cleaning mode of the immunoassay sub-device according to the comparison of the first background voltage value and a preset background voltage threshold value and sending a corresponding cleaning instruction; and the cleaning subsystem is connected with the controller and is used for receiving the cleaning instruction sent by the controller and responding to the cleaning instruction to correspondingly clean the immunoassay subsystem.
In order to solve the technical problems, the application adopts another technical scheme that: there is provided a method of cleaning a sample analysis device, the method being suitable for use with a sample analysis device as described above, the method comprising: controlling the immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device when no sample to be detected exists; determining a cleaning mode of the immunoassay sub-device according to the comparison of the first background voltage value and a preset background voltage threshold value and sending a corresponding cleaning instruction; and responding to the cleaning instruction to perform corresponding cleaning on the immunoassay sub-device.
In order to solve the technical problems, the application adopts another technical scheme that: there is provided a sample analysis device including:
the immunoassay device comprises a colorimetric pool, a laser and a photoelectric receiver, wherein the laser and the photoelectric receiver are respectively arranged at two sides of the colorimetric pool, the colorimetric pool is used for installing a soaking liquid when the colorimetric pool is not used for detection, the colorimetric pool is used for discharging the soaking liquid when the colorimetric pool is used for detection, a base liquid and a sample to be detected are sequentially installed, the laser is used for emitting laser towards the colorimetric pool so that the photoelectric receiver obtains an optical signal and converts the optical signal into an electric signal, and the electric signal obtained when the colorimetric pool discharges the soaking liquid and only the base liquid is used as a first background electric signal;
and the controller is used for receiving the first background electric signal, comparing the first background electric signal with a preset background electric signal and sending out a corresponding cleaning instruction.
In order to solve the technical problems, the application adopts another technical scheme that: there is provided a sample analysis device comprising:
the container is at least used for containing base fluid and a sample to be detected;
the photoelectric detection assembly is used for detecting when the container only holds the base solution to obtain a first background electric signal, and detecting when the container holds the base solution and a sample to be detected to obtain a sample detection electric signal;
and the controller is used for sending a first instruction to clean the container in a first cleaning mode or not when the first background electric signal is smaller than a preset background electric signal threshold value, otherwise sending a second instruction to clean the container in a second cleaning mode, wherein the cleaning strength of the second cleaning mode to the specific substance is larger than that of the first cleaning mode to the specific substance.
The beneficial effects of the application are as follows: in contrast to the prior art, the sample analysis device of the present application comprises an immunoassay sub-device, further comprising: the controller is connected with the immunoassay sub-device and is used for controlling the immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device when no sample to be detected exists, determining a cleaning mode of the immunoassay sub-device according to the comparison of the first background voltage value and a preset background voltage threshold value and sending a corresponding cleaning instruction; and the cleaning subsystem is connected with the controller and is used for receiving the cleaning instruction sent by the controller and responding to the cleaning instruction to correspondingly clean the immunoassay subsystem. The device detects the first background voltage value of the immunoassay sub-device when no sample to be detected exists, determines the cleaning mode of the immunoassay sub-device according to the comparison of the first background voltage value and the preset background voltage threshold value and sends a corresponding cleaning instruction to correspondingly clean the immunoassay sub-device, and determines the cleaning mode of the immunoassay sub-device according to the first background voltage value and the preset background voltage threshold value, namely, determines the cleaning mode according to the actual cleaning state of the immunoassay sub-device and the actual detection requirement instead of only fixedly cleaning the immunoassay sub-device by adopting a certain cleaning mode.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for the description of the embodiments will be briefly described below, and it is apparent that the drawings in the following description are only some embodiments of the present application, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Wherein:
FIG. 1 is a schematic diagram of a sample analyzer according to an embodiment of the present application;
FIG. 2 is a schematic view of another embodiment of a sample analyzer according to the present application;
FIG. 3 is a schematic view of a sample analyzer according to another embodiment of the present application;
FIG. 4 is a flow chart of an embodiment of a method for cleaning a sample analyzer according to the present application;
FIG. 5 is a schematic flow chart of another embodiment of a method for cleaning a sample analyzer of the present application;
FIG. 6 is a schematic view of another embodiment of a sample analysis device according to the present application;
FIG. 7 is a schematic view of another embodiment of the sample analyzer of the present application.
Detailed Description
The following description of the embodiments of the present application will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
Referring to fig. 1, fig. 1 is a schematic structural diagram of an embodiment of a sample analysis device according to the present application, the device includes: an immunoassay subsystem 1, a controller 2 and a washing subsystem 3.
The controller 2 is connected to the immunoassay sub-device 1, and is configured to control the immunoassay sub-device 1 to detect a first background voltage value (or a current value) of the immunoassay sub-device 1 when no sample to be detected (wherein the sample to be detected may be whole blood, plasma, serum, diluted whole blood, plasma, serum, etc.), and the three types of liquids may be added to the immunoassay sub-device 1, including a base liquid and the sample to be detected sequentially during detection, which are not detected, and the base liquid may be a conventional cleaning liquid known to those skilled in the art, such as sodium chloride, where the first background voltage value refers to a voltage value obtained when only the base liquid is added, and the base liquid may be one, two or more than three types of base liquids, such as a latex reagent, and is mainly used to generate an immunological binding reaction with the sample), and determine a cleaning mode of the immunoassay sub-device 1 and send a corresponding cleaning instruction according to a comparison between the first background voltage value and a preset background voltage threshold.
The washing subsystem 3 is connected to the controller 2, and is configured to receive a washing command sent by the controller 2, and perform corresponding washing on the immunoassay subsystem 1 in response to the washing command.
The immunoassay device 1 is used for performing an immunoassay on a sample to be detected, for example, performing a latex immunoassay or the like. The first background voltage value is a background voltage value when the immunoassay sub-device 1 has no sample to be detected, and may represent a current cleaning state of the immunoassay sub-device 1. The preset background voltage threshold may represent the actual detection requirements of the sample and/or instrument, for example: accuracy of the detection result of the sample, detection precision of the instrument, and the like. The preset background voltage threshold may be pre-stored locally, or user input, or imported locally from elsewhere, etc.
The washing subsystem 3 is connected to the controller 2, and receives a washing command sent from the controller 2, and performs corresponding washing on the immunoassay subsystem 1 in response to the washing command. If the original sample analysis device itself includes a part of the cleaning assembly, the cleaning subsystem 3 may include the part of the cleaning assembly, and the cleaning subsystem 3 may also include a new cleaning assembly, and the specific configuration needs to be determined according to the actual situation, which is not limited herein.
The sample analysis device according to the embodiment of the application comprises an immunoassay sub-device, and further comprises: the controller is connected with the immunoassay sub-device and is used for controlling the immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device when no sample to be detected exists, determining a cleaning mode of the immunoassay sub-device according to the comparison of the first background voltage value and a preset background voltage threshold value and sending a corresponding cleaning instruction; and the cleaning subsystem is connected with the controller and is used for receiving the cleaning instruction sent by the controller and responding to the cleaning instruction to correspondingly clean the immunoassay subsystem. The device detects the first background voltage value of the immunoassay sub-device when no sample to be detected exists, determines the cleaning mode of the immunoassay sub-device according to the comparison of the first background voltage value and the preset background voltage threshold value and sends a corresponding cleaning instruction to correspondingly clean the immunoassay sub-device, and determines the cleaning mode of the immunoassay sub-device according to the first background voltage value and the preset background voltage threshold value, namely, determines the cleaning mode according to the actual cleaning state of the immunoassay sub-device and the actual detection requirement instead of only fixedly cleaning the immunoassay sub-device by adopting a certain cleaning mode.
The cleaning mode comprises a first cleaning mode and a second cleaning mode, wherein the first cleaning mode is used for cleaning the immunoassay sub-device by adopting a first cleaning solution, and the second cleaning mode is used for cleaning the immunoassay sub-device by adopting a second cleaning solution.
Further, the first cleaning liquid is a conventional cleaning liquid and the second cleaning liquid is a special cleaning liquid.
The conventional cleaning solution is generally cheaper, the special cleaning solution is more expensive, and according to different cleaning modes, different cleaning solutions are respectively adopted to clean the immunoassay sub-device, so that the use amount of the special cleaning solution can be saved on the basis of meeting the requirements of users, and the cleaning cost is saved. The detection result precision of the immunoassay sub-device and the detection result accuracy of the sample to be detected can be ensured by presetting the background voltage threshold. By the method, the cleaning cost can be saved on the basis of ensuring the precision of the detection result of the immunoassay sub-device and the accuracy of the detection result of the sample to be detected.
In one embodiment, the preset background voltage threshold M is 90 mv, 95 mv, 100 mv, 105 mv, 110 mv, or the like, and the specific values do not limit the present application.
The rationality of limiting the preset background voltage threshold M reduces the consumption of special cleaning liquid for the immunoassay sub-device, saves reagent cost, reduces the risk of reagent pollution, has reliable cleaning effect, and ensures the accuracy of results and the requirements of instrument precision.
In one embodiment, the dedicated cleaning fluid is a hemolysis agent-containing cleaning fluid.
In an embodiment, the controller 2 is specifically configured to control the immunoassay sub-device 1 to detect a first background voltage value of the immunoassay sub-device when no sample to be detected is detected, and when the first background voltage value is smaller than a preset background voltage threshold, the controller is configured to control the immunoassay sub-device 1 to detect a next sample to be detected, determine that a cleaning mode of the immunoassay sub-device 1 after detecting the next sample to be detected is a first cleaning mode, and send a corresponding first cleaning instruction; the washing subsystem 3 receives the first washing instruction sent by the controller 2, and responds to the first washing instruction to carry out corresponding washing on the immunoassay sub-device 1 after the immunoassay sub-device 1 detects the next sample to be detected.
The controller 2 is further configured to determine that the cleaning mode of the immunoassay sub-device 1 is a second cleaning mode when the first background voltage value is greater than or equal to a preset background voltage threshold value, and send a corresponding second cleaning instruction; the washing subsystem 3 receives the second washing command sent by the controller 2, and performs corresponding washing on the immunoassay sub-device 1 in response to the second washing command.
Referring to fig. 2, in one embodiment, the device further comprises a sample providing sub-device 4, an immunoreagent providing device 5, a first wash liquid storage sub-device 6, and a second wash liquid storage sub-device 7.
The sample providing sub-device 4 is connected with the controller 2, the immunoreagent supplying device 5 is respectively connected with the controller 2 and the immunoassay sub-device 1, and the first cleaning solution storing sub-device 6 and the second cleaning solution storing sub-device 7 are connected with the sample providing sub-device 4; the sample providing sub-device 4 provides the sample to be analyzed to the immunoassay sub-device 1 under the control of the controller 2, or provides the first washing liquid in the first washing liquid storage sub-device 6 to the immunoassay sub-device 1 for washing, or provides the second washing liquid in the second washing liquid storage sub-device 7 (for storing the second washing liquid required for washing the immunoassay sub-device 1) to the immunoassay sub-device 1 for washing; the immunological reagent supplying sub-apparatus 5 supplies immunological reagents (e.g., hemolyzing agent, latex reagent, etc.) necessary for detecting a sample to be analyzed to the immunological analyzing sub-apparatus 1 under the control of the controller 2. Wherein the second cleaning liquid storage sub-device 7 is arranged on the travelling path of the sample providing sub-device 4.
In this embodiment, the sample providing sub-device 4 and the first cleaning solution storing sub-device 6 may be configured as the original sample analyzing device itself, and the second cleaning solution storing sub-device 7 is added to the original structure, and the second cleaning solution in the second cleaning solution storing sub-device 7 is still provided to the immunoassay sub-device 1 by the sample providing sub-device 4 for cleaning. I.e. the washing subsystem actually comprises the sample-providing sub-means 4, the first washing-liquid-storing sub-means 6 and the second washing-liquid-storing sub-means 7, in such a way that, on the one hand, the already existing structural components of the original sample-analyzing device can be fully reused, and, on the other hand, the structure of the sample-analyzing device can be made as compact as possible.
Referring to fig. 3, in one embodiment, the device further comprises a sample providing sub-device 4, an immunoreagent providing sub-device 5, a second washing liquid providing sub-device 8, a first washing liquid storage sub-device 6 and a second washing liquid storage sub-device 7.
The sample providing sub-device 4 is connected with the controller 2, the immunoreagent supplying sub-device 5 is connected with the controller 2 and the immunoassay sub-device 1 respectively, the second cleaning solution supplying sub-device 8 (comprising a pipeline, a valve, a syringe or a liquid path element well known to a person skilled in the art such as a quantitative pump) is connected with the controller 2 and the immunoassay sub-device 1 respectively, the first cleaning solution storing sub-device 6 is connected with the sample providing sub-device 4, and the second cleaning solution storing sub-device 7 is connected with the second cleaning solution supplying sub-device 8; the sample providing sub-device 4 provides the sample to be detected to the immunoassay sub-device 1 or provides the first washing liquid in the first washing liquid storage sub-device 6 to the immunoassay sub-device 1 for washing under the control of the controller 2; the second washing liquid supply sub-device 8 supplies the second washing liquid in the second washing liquid storage sub-device 7 to the immunoassay sub-device 1 for washing under the control of the controller 2; the immunoreagent supply sub-unit 5 supplies the immunoreagent required for detecting the sample to be detected to the immunoassay sub-unit 1 under the control of the controller 2. Wherein the second cleaning liquid storage sub-means 7 is arranged inside or outside the sample analysis device.
In the present embodiment, the sample providing sub-device 4 and the first washing liquid storing sub-device 6 may be regarded as a structure of the original sample analyzing device itself, and the second washing liquid supplying sub-device 8 and the second washing liquid storing sub-device 7 may be added on the basis of the structure, and the second washing liquid in the second washing liquid storing sub-device 7 may be supplied to the immunoassay sub-device 1 for washing by the newly added second washing liquid supplying sub-device 8 instead of using the sample providing sub-device 4. That is, the cleaning subsystem actually comprises the sample providing sub-device 4, the first cleaning liquid storage sub-device 6, the second cleaning liquid supply sub-device 8 and the second cleaning liquid storage sub-device 7, in such a way that modification of the sample analysis device can be made as small as possible, and modification of the original sample analysis device is simple and convenient.
Further, the sample providing sub-device 4 comprises a sampling needle, a drive assembly and a tubing.
Referring to fig. 4, fig. 4 is a flow chart of an embodiment of a method for cleaning a sample analyzer according to the present application, which is applicable to the sample analyzer according to any one of the above, and details of the related content are referred to the above device parts, which are not described herein. The method comprises the following steps:
step S101: and controlling the immunoassay sub-device to detect the first background voltage value of the immunoassay sub-device when no sample to be detected exists.
Step S102: and determining a cleaning mode of the immunoassay sub-device according to the first background voltage value and the preset background voltage threshold value, and sending a corresponding cleaning instruction.
Step S103: and responding to the cleaning instruction to perform corresponding cleaning on the immunoassay sub-device.
The embodiment of the application controls the immunoassay sub-device to detect the first background voltage value of the immunoassay sub-device when no sample to be detected exists; determining a cleaning mode of the immunoassay sub-device according to the comparison of the first background voltage value and the preset background voltage threshold value, and sending a corresponding cleaning instruction; and responding to the cleaning instruction to perform corresponding cleaning on the immunoassay sub-device. The first background voltage value of the immunoassay sub-device is detected when no sample to be detected exists, the cleaning mode of the immunoassay sub-device is determined according to the comparison of the first background voltage value and the preset background voltage threshold value, and a corresponding cleaning instruction is sent to correspondingly clean the immunoassay sub-device, and the cleaning mode of the immunoassay sub-device is determined according to the first background voltage value and the preset background voltage threshold value, namely, the cleaning mode is determined according to the actual cleaning state of the immunoassay sub-device and the actual detection requirement, instead of only fixedly cleaning the immunoassay sub-device by adopting a certain cleaning mode, so that technical support is provided for saving specific cleaning liquid and reducing the risk of pollution of the specific cleaning liquid on the basis of ensuring the cleaning effect, the detection precision of the device and the accuracy of the sample detection result.
The cleaning mode comprises a first cleaning mode and a second cleaning mode, wherein the first cleaning mode is used for cleaning the immunoassay sub-device by adopting a first cleaning solution, and the second cleaning mode is used for cleaning the immunoassay sub-device by adopting a second cleaning solution.
Wherein the first cleaning liquid is a conventional cleaning liquid and the second cleaning liquid is a special cleaning liquid.
The preset background voltage threshold M is 90 millivolts, 95 millivolts, 100 millivolts, 105 millivolts or 110 millivolts, and the specific values do not limit the present application.
Wherein the special cleaning liquid is a cleaning liquid containing a hemolytic agent. The hemolysis agent can contain quaternary ammonium salt cationic surfactant to dissolve red blood cells, and the liquid containing the hemolysis agent component can be directly used for cleaning reaction residues of the immunoassay sub-device; in addition, the liquid containing the hemolytic agent component is common liquid in sample analysis, so that other special cleaning liquid does not need to be specially prepared, the process can be simplified, and the reagent cost can be further saved.
Step S101, where the immunoassay sub-device is controlled to detect a first background voltage value of the immunoassay sub-device when there is no sample to be detected, may specifically include: controlling an immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device when no sample to be detected exists after the measurement of the cleaning sample; step S102 determines a cleaning mode of the immunoassay sub-device according to the comparison between the first background voltage value and the locally stored preset background voltage threshold value and sends a corresponding cleaning instruction, which may specifically include: when the first background voltage value is smaller than a preset background voltage threshold value, determining that the cleaning mode of the immunoassay sub-device is a first cleaning mode, and sending a corresponding first cleaning instruction, and when the first background voltage value is larger than or equal to the preset background voltage threshold value, determining that the cleaning mode of the immunoassay sub-device is a second cleaning mode, and sending a corresponding second cleaning instruction; step S103, in response to the cleaning instruction, may specifically include: the immunoassay sub-device is correspondingly cleaned in response to the first cleaning instruction, or the immunoassay sub-device is correspondingly cleaned in response to the second cleaning instruction.
Step S101, where the immunoassay sub-device is controlled to detect a background voltage value of itself when there is no sample to be detected, may specifically include: controlling an immunoassay sub-device to detect a second background voltage value of the immunoassay sub-device before sample detection when no sample to be detected exists; step S102 determines a cleaning mode of the immunoassay sub-device according to the comparison between the background voltage value and the preset background voltage threshold value and sends a corresponding cleaning instruction, and specifically may include: when the second background voltage value is smaller than a preset background voltage threshold value, determining that the cleaning mode of the immunoassay sub-device is a first cleaning mode, and sending a corresponding first cleaning instruction, and when the second background voltage value is larger than or equal to the preset background voltage threshold value, determining that the cleaning mode of the immunoassay sub-device is a second cleaning mode, and sending a corresponding second cleaning instruction; step S103, in response to the cleaning instruction, may specifically include: the immunoassay sub-device is correspondingly cleaned in response to the first cleaning instruction, or the immunoassay sub-device is correspondingly cleaned in response to the second cleaning instruction.
Further, the performing, in response to the first cleaning instruction, the corresponding cleaning of the immunoassay sub-device, or in response to the second cleaning instruction, may specifically include:
the sample providing sub-device is controlled to provide the first washing liquid in the first washing liquid storage sub-device to the immunoassay sub-device for washing in response to the first washing instruction, or is controlled to provide the second washing liquid in the second washing liquid storage sub-device to the immunoassay sub-device for washing in response to the second washing instruction.
Further, the performing, in response to the first cleaning instruction, the corresponding cleaning of the immunoassay sub-device, or in response to the second cleaning instruction, may specifically include:
controlling the sample providing sub-device to provide the first washing liquid in the first washing liquid storage sub-device to the immunoassay sub-device for washing in response to the first washing command; or, controlling the second washing liquid supply sub-device to supply the second washing liquid in the second washing liquid storage sub-device to the immunoassay sub-device for washing in response to the second washing instruction.
For example, referring to fig. 5, in a practical application, the method may be implemented as follows:
step S201: switching an immunoassay mode to detect a first background voltage value in an immunoassay sub-device;
step S202: judging whether the first background voltage value of the immunoassay sub-device is smaller than a defined preset background voltage threshold M or not;
step S203: if the first background voltage value is smaller than the preset background voltage threshold value M, the sample providing sub-device 1 is allowed to collect the sample to be detected and provide the sample to be detected to the immunoassay sub-device, and the immunoassay sub-device discharges the sample liquid and cleans the sample liquid by conventional dilution liquid (namely first cleaning liquid) after sample analysis;
step S204: after the sample is detected, continuously detecting a first background voltage value in the immunoassay sub-device, and returning to the step S202;
step S205: if the first background voltage value in step S202 is greater than or equal to the preset background voltage threshold value M, the sample providing sub-device sucks the special cleaning solution from the special cleaning solution storage sub-device (i.e. the second cleaning solution storage sub-device) and conveys the special cleaning solution to the immunoassay sub-device for cleaning;
step S206: after the cleaning is finished, the first background voltage value is continuously detected and the step S202 is returned.
The rationality of limiting the preset background voltage threshold M reduces the consumption of special cleaning liquid for the immunoassay sub-device, saves reagent cost, reduces the risk of reagent pollution, has reliable cleaning effect, and ensures the accuracy of a sample detection result and the requirement of the precision of an instrument detection result.
Referring to fig. 6, an embodiment of the present application further provides a sample analysis device, which includes an immunoassay subsystem 11, a controller 21, and a cleaning subsystem 31.
The immunoassay sub-device 11 comprises a cuvette 12, and a laser 14 and a photoelectric receiver 13 which are respectively arranged at two sides of the cuvette 12, wherein the cuvette 12 is used for accommodating a soaking solution when not in detection, the cuvette 12 is used for discharging the soaking solution when in detection and sequentially accommodating a base solution and a sample to be detected, the laser 14 is used for emitting laser towards the cuvette 12 so that the photoelectric receiver 13 obtains an optical signal and converts the optical signal into an electrical signal, and the electrical signal obtained by the photoelectric receiver 13 when the cuvette discharges the soaking solution and only accommodates the base solution is a first background electrical signal; the controller 21 is configured to receive the first background electrical signal, compare the first background electrical signal with a preset background electrical signal, and send a corresponding cleaning instruction; the cleaning subsystem 31 is configured to perform a corresponding cleaning of the cuvette in response to the cleaning instruction, where:
when the first background electric signal is smaller than the preset background electric signal, the controller 21 sends out a first cleaning instruction to enable the cleaning subsystem 11 to clean the cuvette by adopting a first cleaning solution;
when the first background electric signal is greater than or equal to the preset background electric signal, the controller 21 sends a second cleaning instruction to enable the cleaning subsystem 11 to clean the cuvette by adopting a second cleaning solution, wherein the cleaning strength of the second cleaning solution on a specific substance is greater than that of the first clear liquid on the specific substance. The specific substance may be an immunoreactive conjugate or a reaction residue.
The sample analysis device provided in this embodiment can detect samples when the bottom solution and the sample to be detected are sequentially installed in the cuvette 12, and determine whether to use the special cleaning solution to clean by using the state when only the bottom solution is installed in the cuvette 12, unlike the mode that the special cleaning solution is used to clean at regular time (for example, every one hour) or quantitatively (for example, every 100 samples are washed) in the prior art, the device provided in this embodiment can accurately determine whether to use the special cleaning solution to clean, thereby achieving the purpose of intelligently triggering the special cleaning solution to clean and saving the special cleaning solution.
Referring to fig. 7, an embodiment of the present application further provides a sample analysis device, which includes a container 25, a photodetection assembly 23, and a controller 22.
Wherein the container 25 is at least used for containing a base fluid and a sample to be detected; the photoelectric detection component 23 is configured to detect when the container 25 only holds the base solution to obtain a first background electric signal, and detect when the container 25 holds the base solution and a sample to be detected to obtain a sample detection electric signal; the controller 22 is configured to issue a first instruction to perform a first cleaning mode of cleaning or not cleaning the container when the first background electrical signal is less than a preset background electrical signal threshold value, and issue a second instruction to perform a second cleaning mode of cleaning the container, wherein the cleaning intensity of the second cleaning mode for the specific substance is greater than the cleaning intensity of the first cleaning mode for the specific substance. The first cleaning mode and the second cleaning mode may be performed by the cleaning subsystem 32, and the specific configuration of the cleaning subsystem 32 may refer to the foregoing embodiment, which is not described in detail in this embodiment.
The container 25 may be the cuvette 12 or other reaction tank in the foregoing embodiment, and the components of the base solution and the sample to be detected include, but are not limited to, those described in the foregoing embodiment, so long as the sample to be detected is detected by sequentially adding liquid, the second cleaning mode may be determined by comparing the first background electric signal in the intermediate state (i.e. the state where one, two or three or more base solutions are added) with the preset background electric signal.
In this embodiment, the container 25 is used to detect only the base solution to obtain the first background electric signal, and the first background electric signal is used as a trigger condition for judging whether the cleaning needs to be performed by using a special cleaning solution, so that the cleaning efficiency can be improved, and the accuracy of the sample detection result and the requirement of the precision of the instrument detection result are ensured.
The foregoing description is only of embodiments of the present application, and is not intended to limit the scope of the application, and all equivalent structures or equivalent processes using the descriptions and the drawings of the present application or directly or indirectly applied to other related technical fields are included in the scope of the present application.
Claims (15)
1. A sample analysis device comprising an immunoassay sub-device, the device further comprising:
the controller is connected with the immunoassay sub-device and is used for controlling the immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device when no sample to be detected exists, determining a cleaning mode of the immunoassay sub-device according to the comparison of the first background voltage value and a preset background voltage threshold value and sending a corresponding cleaning instruction;
the cleaning mode comprises a first cleaning mode and a second cleaning mode, wherein the first cleaning mode is that the immunoassay sub-device is cleaned by adopting a first cleaning liquid or is not cleaned by adopting a second cleaning liquid, and the second cleaning mode is that the immunoassay sub-device is cleaned by adopting a second cleaning liquid; the first cleaning liquid is a conventional cleaning liquid, and the second cleaning liquid is a special cleaning liquid;
the controller is further configured to send a first cleaning instruction to perform cleaning in a first cleaning mode or not when the first background voltage value is smaller than the preset background voltage threshold, and send a second cleaning instruction to perform cleaning in a second cleaning mode on the immunoassay sub-device when the first background voltage value is greater than or equal to the preset background voltage threshold;
and the cleaning subsystem is connected with the controller and is used for receiving the cleaning instruction sent by the controller and responding to the first cleaning instruction or the second cleaning instruction to carry out corresponding cleaning on the immunoassay sub-device.
2. The apparatus of claim 1, wherein the preset background voltage threshold M is 90 millivolts, 95 millivolts, 100 millivolts, 105 millivolts, or 110 millivolts.
3. The device of claim 1, wherein the dedicated cleaning fluid is a hemolysis agent-containing cleaning fluid.
4. The device according to claim 1, wherein the controller is specifically configured to control the immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device when no sample to be detected is present after washing, and when the first background voltage value is smaller than the preset background voltage threshold value, the controller controls the immunoassay sub-device to detect a next sample to be detected, and determines that a washing mode of the immunoassay sub-device after detecting the next sample to be detected is a first washing mode, and sends a corresponding first washing instruction; the cleaning subsystem receives a first cleaning instruction sent by the controller and responds to the first cleaning instruction to correspondingly clean the immunoassay sub-device after the immunoassay sub-device detects the next sample to be detected;
when the first background voltage is greater than or equal to the preset background voltage threshold, the controller determines that the cleaning mode of the immunoassay sub-device is a second cleaning mode and sends a corresponding second cleaning instruction; and the cleaning subsystem receives a second cleaning instruction sent by the controller and responds to the second cleaning instruction to correspondingly clean the immunoassay sub-device.
5. The device of claim 1, further comprising a sample providing sub-device, an immunoreagent providing sub-device, a first wash fluid storage sub-device, and a second wash fluid storage sub-device,
the sample providing sub-device is respectively connected with the controller and the immunoassay sub-device, the immunoreagent supplying sub-device is respectively connected with the controller and the immunoassay sub-device, and the first cleaning solution storing sub-device and the second cleaning solution storing sub-device are both connected with the sample providing sub-device;
the sample providing sub-device provides a sample to be analyzed to the immunoassay sub-device under the control of the controller, or provides the first cleaning solution in the first cleaning solution storage sub-device to the immunoassay sub-device for cleaning, or provides the second cleaning solution in the second cleaning solution storage sub-device to the immunoassay sub-device for cleaning;
the immunoreagent supplying sub-device supplies immunoreagent required for detecting the sample to be analyzed to the immunoassay sub-device under the control of the controller;
the second cleaning liquid storage sub-device is arranged on the walking path of the sample providing sub-device.
6. The device of claim 1, further comprising a sample providing sub-device, an immunoreagent providing sub-device, a second wash fluid providing sub-device, a first wash fluid storage sub-device, and a second wash fluid storage sub-device,
the sample providing sub-device is respectively connected with the controller and the immunoassay sub-device, the immunoreagent supplying sub-device is respectively connected with the controller and the immunoassay sub-device, the second cleaning solution supplying sub-device is respectively connected with the controller and the immunoassay sub-device, the first cleaning solution storing sub-device is connected with the sample providing sub-device, and the second cleaning solution storing sub-device is connected with the second cleaning solution supplying sub-device;
the sample providing sub-device provides a sample to be detected to the immunoassay sub-device or provides the first cleaning solution in the first cleaning solution storage sub-device to the immunoassay sub-device for cleaning under the control of the controller;
the second cleaning liquid supply sub-device is controlled by the controller to supply the second cleaning liquid in the second cleaning liquid storage sub-device to the immunoassay sub-device for cleaning;
the immunoreagent supplying sub-device supplies immunoreagent required for detecting the sample to be detected to the immunoassay sub-device under the control of the controller;
the second cleaning solution storage sub-device is disposed inside or outside the sample analysis device.
7. The device of any one of claims 5 or 6, wherein the sample providing sub-device comprises a sampling needle, a drive assembly, and a tubing.
8. A method of cleaning a sample analysis device, characterized by being applied to the sample analysis device according to any one of claims 1 to 7, the method comprising:
controlling an immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device when no sample to be detected exists;
determining a cleaning mode of the immunoassay sub-device according to the comparison of the first background voltage value and a preset background voltage threshold value and sending a corresponding cleaning instruction;
the cleaning mode comprises a first cleaning mode and a second cleaning mode, wherein the first cleaning mode is that the immunoassay sub-device is cleaned by adopting a first cleaning liquid or is not cleaned by adopting a second cleaning liquid, and the second cleaning mode is that the immunoassay sub-device is cleaned by adopting a second cleaning liquid; the first cleaning liquid is a conventional cleaning liquid, and the second cleaning liquid is a special cleaning liquid;
when the first background voltage value is smaller than the preset background voltage threshold value, a first cleaning instruction is sent to clean or not clean the immunoassay sub-device in a first cleaning mode, and when the first background voltage value is larger than or equal to the preset background voltage threshold value, a second cleaning instruction is sent to clean the immunoassay sub-device in a second cleaning mode;
and responding to the first washing instruction or the second washing instruction to carry out corresponding washing on the immunoassay sub-device.
9. The method of claim 8, wherein the preset background voltage threshold M is 90 millivolts, 95 millivolts, 100 millivolts, 105 millivolts, or 110 millivolts.
10. The method of claim 8, wherein the dedicated cleaning fluid is a hemolysis agent-containing cleaning fluid.
11. The method of claim 8, wherein said controlling the immunoassay sub-device to detect a first background voltage value of itself when there is no sample to be detected comprises:
controlling the immunoassay sub-device to detect a first background voltage value of the immunoassay sub-device after cleaning and when no sample to be detected exists;
the determining the cleaning mode of the immunoassay sub-device according to the comparison of the first background voltage value and the preset background voltage threshold value and sending a corresponding cleaning instruction comprises the following steps:
when the first background voltage value is smaller than the preset background voltage threshold value, the controller controls the immunoassay sub-device to detect a next sample to be detected, determines that a cleaning mode of the immunoassay sub-device after detecting the next sample to be detected is a first cleaning mode, and sends a corresponding first cleaning instruction, and when the first background voltage value is larger than or equal to the preset background voltage threshold value, the controller determines that the cleaning mode of the immunoassay sub-device is a second cleaning mode, and sends a corresponding second cleaning instruction;
the performing, in response to the cleaning instruction, a corresponding cleaning of the immunoassay sub-device includes:
and responding to the first cleaning instruction to perform corresponding cleaning on the immunoassay sub-device after the immunoassay sub-device detects the next sample to be detected, or responding to the second cleaning instruction to perform corresponding cleaning on the immunoassay sub-device.
12. The method of claim 11, wherein the performing a corresponding wash of the immunoassay sub-device after the immunoassay sub-device detects a next sample to be detected in response to the first wash instruction, or performing a corresponding wash of the immunoassay sub-device in response to the second wash instruction, comprises:
controlling a sample providing sub-device to provide a first cleaning solution in a first cleaning solution storage sub-device to the immunoassay sub-device for cleaning after the immunoassay sub-device detects a next sample to be detected in response to the first cleaning command,
or, in response to the second washing instruction, controlling the sample providing sub-device to provide the second washing liquid in the second washing liquid storage sub-device to the immunoassay sub-device for washing.
13. The method of claim 11, wherein the performing a corresponding wash of the immunoassay sub-device after the immunoassay sub-device detects a next sample to be detected in response to the first wash instruction, or performing a corresponding wash of the immunoassay sub-device in response to the second wash instruction, comprises:
controlling a sample providing sub-device to provide a first cleaning solution in a first cleaning solution storage sub-device to the immunoassay sub-device for cleaning after the immunoassay sub-device detects a next sample to be detected in response to the first cleaning command;
or, in response to the second washing instruction, controlling the second washing liquid supply sub-device to supply the second washing liquid in the second washing liquid storage sub-device to the immunoassay sub-device for washing.
14. A sample analysis device, comprising:
the immunoassay device comprises a colorimetric pool, a laser and a photoelectric receiver, wherein the laser and the photoelectric receiver are respectively arranged at the side edge of the colorimetric pool, the colorimetric pool is used for installing a soaking liquid when the colorimetric pool is not used for detection, the soaking liquid is used for discharging the soaking liquid and installing a base liquid and a sample to be detected when the colorimetric pool is used for detection, the laser is used for emitting laser towards the colorimetric pool so that the photoelectric receiver obtains an optical signal and converts the optical signal into an electric signal, and the electric signal obtained by the photoelectric receiver when the colorimetric pool discharges the soaking liquid and only the base liquid is used as a first background electric signal;
the controller is used for obtaining the first background electric signal, comparing the first background electric signal with a preset background electric signal and sending out a corresponding cleaning instruction;
the sample analysis device further includes a washing subsystem for performing a corresponding washing of the cuvette in response to the washing instructions, wherein:
when the first background electric signal is smaller than the preset background electric signal, the controller sends out a first cleaning instruction to enable the cleaning subsystem to clean the cuvette by adopting a first cleaning solution;
when the first background electric signal is greater than or equal to the preset background electric signal, the controller sends a second cleaning instruction to enable the cleaning subsystem to clean the cuvette by adopting a second cleaning liquid, wherein the cleaning strength of the second cleaning liquid on a specific substance is greater than that of the first cleaning liquid on the specific substance.
15. A sample analysis device, comprising:
the container is at least used for containing base fluid and a sample to be detected;
the photoelectric detection assembly is used for detecting when the container only holds the base solution to obtain a first background electric signal, and detecting when the container holds the base solution and a sample to be detected to obtain a sample detection electric signal;
the controller is used for sending a first instruction to clean the container in a first cleaning mode or not when the first background electric signal is smaller than a preset background electric signal threshold value, otherwise sending a second instruction to clean the container in a second cleaning mode, and the cleaning strength of the second cleaning mode on a specific substance is larger than that of the first cleaning mode on the specific substance;
the first cleaning mode is to clean the container by using a first cleaning liquid or not clean the container, and the second cleaning mode is to clean the container by using a second cleaning liquid; the first cleaning liquid is a conventional cleaning liquid, and the second cleaning liquid is a special cleaning liquid.
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| CN113311163B (en) * | 2020-02-26 | 2024-04-12 | 深圳迈瑞生物医疗电子股份有限公司 | Cleaning method of detection pool |
| CN114113566A (en) * | 2020-08-28 | 2022-03-01 | 深圳市帝迈生物技术有限公司 | Method for detecting clogging of sampling needle, blood analyzer, and computer storage medium |
| CN114308849B (en) * | 2020-09-29 | 2023-04-18 | 深圳市帝迈生物技术有限公司 | Method for avoiding liquid level error detection and sample analyzer |
| CN115524504A (en) * | 2021-06-25 | 2022-12-27 | 深圳市帝迈生物技术有限公司 | Sample analysis device, cleaning method thereof and computer-readable storage medium |
| CN114002424A (en) * | 2021-12-31 | 2022-02-01 | 深圳市帝迈生物技术有限公司 | Sample analyzer and detection method thereof |
| CN114002423A (en) * | 2021-12-31 | 2022-02-01 | 深圳市帝迈生物技术有限公司 | Sample analyzer and detection method thereof |
| CN114618853A (en) * | 2022-05-11 | 2022-06-14 | 深圳市帝迈生物技术有限公司 | Cleaning method of sample analyzer and sample analyzer |
| CN114791502B (en) * | 2022-06-13 | 2022-10-28 | 深圳市帝迈生物技术有限公司 | Sample detection method and sample analyzer |
| CN114871210B (en) * | 2022-07-08 | 2022-10-28 | 深圳市帝迈生物技术有限公司 | Cleaning method of sample analyzer, sample analyzer and control device thereof |
| CN115791642A (en) * | 2022-11-17 | 2023-03-14 | 浙江西热利华智能传感技术有限公司 | Photoelectric conversion system and method |
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| CN1346058A (en) * | 2000-09-22 | 2002-04-24 | 迪亚西斯公司 | Apparatus for automatic treating liquid sample |
| JP2004356356A (en) * | 2003-05-29 | 2004-12-16 | Oki Electric Ind Co Ltd | Method for judging completion of cleaning and cleaning apparatus |
| JP2008107447A (en) * | 2006-10-24 | 2008-05-08 | Kyocera Mita Corp | Image forming apparatus |
| CN201302575Y (en) * | 2008-10-07 | 2009-09-02 | 丁卫东 | Cleaning device with clogging alarm apparatus |
| CN102912453A (en) * | 2011-08-06 | 2013-02-06 | 郑修余 | Eiderdown cleaning system |
| CN104437099B (en) * | 2014-12-19 | 2016-09-07 | 山东中保康医疗器具有限公司 | The detection method of single use filter for removing white blood cell film material water for cleaning |
| JP6633474B2 (en) * | 2015-08-17 | 2020-01-22 | アイロボット・コーポレーション | Autonomous floor cleaning using removable pads |
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| CN105627518A (en) * | 2016-01-20 | 2016-06-01 | 广东美的制冷设备有限公司 | Filth blockage detecting method and device of air conditioner |
| CN106111593A (en) * | 2016-07-14 | 2016-11-16 | 广东美的厨房电器制造有限公司 | Control the method and apparatus carrying out Fouling Cleaning |
| CN107643410B (en) * | 2016-07-21 | 2021-04-02 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyzer and cleaning control method for sample analyzer |
| CN107643393B (en) * | 2016-07-21 | 2021-11-05 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analyzer, method for cleaning sample analyzer, and use of liquid containing hemolytic agent component |
| JP6918490B2 (en) * | 2016-12-28 | 2021-08-11 | シスメックス株式会社 | Analytical method and analyzer |
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