CN107643410B - Sample analyzer and cleaning control method for sample analyzer - Google Patents
Sample analyzer and cleaning control method for sample analyzer Download PDFInfo
- Publication number
- CN107643410B CN107643410B CN201610581147.3A CN201610581147A CN107643410B CN 107643410 B CN107643410 B CN 107643410B CN 201610581147 A CN201610581147 A CN 201610581147A CN 107643410 B CN107643410 B CN 107643410B
- Authority
- CN
- China
- Prior art keywords
- sample
- detection
- threshold
- measurement
- cleaning
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention relates to a sample analyzer, which comprises a sample suction device, a reaction tank, a detector, a cleaning solution storage tank, a liquid transmission device and a cleaning controller, wherein the sample suction device sucks and conveys a sample to be detected to the reaction tank for measurement reaction, the detector detects a detection item of a reactant generated by the measurement reaction, cleaning solution is stored in the cleaning solution storage tank, the cleaning controller is respectively connected with the sample suction device and the detector to obtain a detection parameter, judges whether the residual reactant exceeds the standard or not according to the detection parameter, and controls the liquid transmission device to suck the cleaning solution from the cleaning solution storage tank to execute cleaning operation when the residual reactant exceeds the standard. The invention also relates to a cleaning control method of the sample analyzer.
Description
Technical Field
The present invention relates to a sample analyzer and a cleaning control method for cleaning the sample analyzer.
Background
When the conventional sample analyzer uses the immune latex method to measure, a sample to be measured and a reaction reagent are generally required to react in a reaction tank, and a part of reactants can remain in the reaction tank after the test is completed. The residual reactants accumulated in the reaction tank to a certain amount affect the accuracy of the subsequent measurement values, so that the residual reactants need to be cleaned. Common cleaning methods include cleaning after each test and periodic cleaning at intervals. However, cleaning after each inspection and periodic cleaning reduce the cleaning effect while ensuring the cleaning effect, and it is difficult to meet the current requirement for the test speed.
Disclosure of Invention
In view of the above, it is desirable to provide an optimized sample analyzer and a washing control method applied to the sample analyzer, which performs a washing operation according to a real-time measurement situation.
A sample analyzer comprises a sample suction device, a reaction tank, a detector, a cleaning liquid storage tank, a liquid transmission device and a cleaning controller, wherein the sample suction device sucks and conveys a sample to be detected to the reaction tank for measurement reaction, the detector detects a reactant generated by the measurement reaction for detection items, cleaning liquid is stored in the cleaning liquid storage tank, the cleaning controller is respectively connected with the sample suction device and the detector to obtain detection parameters, judges whether the residual reactant exceeds the standard or not according to the detection parameters, and controls the liquid transmission device to suck the cleaning liquid from the cleaning liquid storage tank to execute cleaning operation when the residual reactant exceeds the standard.
A cleaning control method of a sample analyzer, the sample analyzer is used for detecting detection items of reactants generated by a sample to be detected and a reaction reagent, and at least one threshold value related to the residual quantity of the reactants is set, the cleaning control method comprises the following steps:
acquiring and storing detection parameters of detection items;
comparing the acquired detection parameters with a preset threshold value;
judging whether the residual quantity of the reactants exceeds the standard or not according to the comparison result;
and if the residual quantity of the reactant exceeds the standard, cleaning the sample analyzer.
Compared with the prior art, the sample analyzer and the cleaning control method applied to the sample analyzer provided by the invention judge the residual quantity of the reactant according to the obtained detection parameters, and reasonably set the cleaning time of the sample analyzer, so that the cleaning times are reduced on the premise of ensuring that the residual quantity of the reactant does not influence the detection result when the sample analyzer is used for detection, the detection cost is reduced, and the detection efficiency is improved.
Drawings
Fig. 1 is a schematic structural view of a sample analyzer according to a first embodiment of the present invention.
Fig. 2 is a schematic structural view of a sample analyzer according to a second embodiment of the present invention.
Fig. 3 is a flowchart illustrating steps of a cleaning control method according to the present invention.
Description of the main elements
| Sample analyzer | 1 |
| |
10 |
| |
11 |
| |
12 |
| |
13 |
| Cleaning |
14 |
| |
15、25 |
| Human- |
16 |
| |
17 |
| Processor with a memory having a plurality of |
18 |
| Bus line | 100 |
| |
19 |
| Infusion pipeline | 150 |
| Valve |
152 |
| Pump and method of operating the same | 154 |
| |
190 |
| |
192 |
| |
194 |
| |
196 |
| |
250 |
| |
252 |
The following detailed description will further illustrate the invention in conjunction with the above-described figures.
Detailed Description
First embodiment
As shown in fig. 1, a sample analyzer 1 according to a first embodiment of the present invention is used for analyzing a collected sample to be measured. Such assays include, but are not limited to, assays for acute phase proteins (CRP), White Blood Cells (WBC), Hemoglobin (HGB), Red Blood Cells (RBC), Platelets (PLT), and the like.
The sample analyzer 1 comprises a sample suction device 10, a reagent tank 11, a reaction cell 12, a detector 13, a cleaning solution storage tank 14, a liquid transmission device 15, a human-computer interaction device 16, a memory 17 and a processor 18. The sample suction means 10, the reagent well 11, the reaction cell 12, and the cleaning solution storage tank 14 are directly or indirectly connected to each other via a liquid transfer means 15 for liquid transfer. The sample aspiration device 10, the detector 13, the human interaction device 16, the memory 17 and the processor 18 are electrically connected directly or indirectly via a bus 100 to transmit and exchange data or signals. It is understood that the reagent tank 11, the reaction chamber 12, and the cleaning solution storage tank 14 can also be electrically connected to the sample sucking device 10, the detector 13, the human-computer interaction device 16, the memory 17, and the processor 18 via the bus 100 to transmit and exchange data or signals, so as to realize automation control.
The sample suction device 10 is used for sucking a sample to be tested and introducing the sample into the reaction cell 12. The reagent tank 11 is used for storing a reaction reagent required for analyzing a sample to be tested. It is understood that the required reaction reagent may be one or more, and each reaction reagent is separately stored in one reagent reservoir 11, depending on the sample to be analyzed. Therefore, the reagent tank 11 may be one or more according to the sample to be analyzed.
The reaction tank 12 is used for carrying out a measurement reaction, and a sample to be measured and a corresponding reaction reagent are mixed according to a predetermined ratio and then are subjected to the measurement reaction in the reaction tank 12 to generate a reactant. The detector 13 is used for detecting the detection items of the reactants, and the quantity value of the detected target substance in the sample can be obtained by measuring the content of the specific components in the generated reactants.
The cleaning liquid storage tank 14 is for storing a cleaning liquid. In this embodiment, the washing solution is a hemolytic agent. It is understood that, if the hemolytic agent is one of the reaction reagents, it may be stored in the reagent tank 11, where the cleaning solution storage tank 14 may be replaced with one of the reagent tanks 11.
The human-computer interaction device 16 is used for realizing interaction operation between a user and the sample analyzer 1, and the interaction operation includes, but is not limited to, inputting instructions or data and outputting detection results. The human-computer interaction device 16 includes but is not limited to a touch display screen, a keyboard, and a microphone.
An operating system for controlling the operation of the sample analyzer 1 is stored in the memory 17. The operating system is run by the processor 18 and interacts with the user through the human interaction device 16. The sample analyzer 1 performs various tests under the control of an operating system.
The cleaning controller 19 provided by the present invention is disposed in the sample analyzer 1, may be a subsystem of the operating system, may be stored in the memory 17 independently of the operating system, or may be Firmware (Firmware) solidified on the memory 17 without being directly controlled by the operating system. The cleaning controller 19 is connected to the sample suction device 10 and the detector 13, respectively, to obtain detection parameters of detection items to determine the residual amount of the reactant, and controls the liquid transfer device 15 to draw the cleaning liquid from the cleaning liquid storage tank 14 according to the residual amount of the reactant to clean the sample analyzer 1.
In this embodiment, the liquid transfer means 15 includes a liquid supply line 150 connecting the cleaning liquid storage tank 14 and the reaction tank 12, a valve 152, and a pump 154. The wash controller 19 determines when to draw wash solution from the solution reservoir 14 to wash the reaction cuvette 12 by controlling the opening and closing of the valve 152 and/or the opening and closing of the pump 154.
The cleaning controller 19 includes a detection module 190, a setting module 192, a comparison module 194, and an execution module 196. The modules 190-196 may be a set of logical relationships embedded in hardware or firmware, or a series of programs written in a programming language that are stored in memory 17 or other firmware. The programs may be executed by at least one of the processors 18 to implement particular functions.
The detecting module 190 is connected to the detector 13 and/or the sample sucking device 10 of the sample analyzer 1, and is configured to acquire and store the detecting parameters of the detecting items in the reaction cell 12. The detection parameters obtained by the detection module 190 include a measurement value of each detection of the detection item and/or a sample size of the sample to be detected corresponding to the measurement value, and the obtained detection parameters are stored in the designated area of the memory 17 in sequence. The sample size here can be the real sample volume of the sample to be measured, for example, 3ul, 5ul, or can be the reference amount of the sample to be measured, for example, 1 sample size is represented by 1.
The setting module 192 is connected to the human-computer interaction device 16, and is configured to set a threshold related to a residual amount of a reactant according to an input operation of a user. The user may input the threshold value through the human-computer interaction device 16, and the threshold value may be stored in the memory 17 in advance for the user to call. The set threshold value comprises a first measurement threshold value or a second measurement threshold value related to the measurement value of the detection item in the detection item, a first sample volume threshold value or a second sample volume threshold value related to the sample volume of the sample to be measured, or a third measurement threshold value related to the accumulated total number of the measurement values measured for multiple times in the detection item. It is understood that, for the same detection item, the second measurement threshold may be a plurality of different values lower than the first measurement threshold, and each second measurement threshold corresponds to a first sample amount threshold to determine the residual amount of the reactant. And for different detection items, the first measurement threshold, the second sample size threshold and the third measurement threshold can be adjusted adaptively due to different generated reactants.
The comparing module 194 is connected to the detecting module 190 and the setting module 192, and configured to compare the detecting parameter obtained by the detecting module 190 with the set corresponding threshold, and determine whether the residual amount of the reactant exceeds the standard according to the comparison result.
Specifically, the comparing module 194 compares the detection parameter with at least one set corresponding threshold to determine that the residual level exceeds the threshold. For example: because more measured object content in the sample leads to more generated reactant in the measurement reaction, a reasonable first measurement threshold is set according to the relation characteristic of the measured object content and the generated reactant quantity, when the obtained measurement value is greater than or equal to the set first measurement threshold, the comparison module 194 judges that the residual amount of the reactant exceeds the standard, and when the obtained measurement value is less than the set first measurement threshold, the comparison module 194 judges that the residual amount of the reactant does not exceed the standard.
If the measured value of the detected object does not exceed the first measurement threshold value every time, however, there is a risk that the reactant generated by even a lower measured value may exceed the first measurement threshold value after being accumulated for a plurality of times, so in another embodiment, the detection module 190 obtains the measured value of the detection item and the sample size of the sample to be detected corresponding to the measured value as the detection parameter. The setting module 192 sets a second measurement threshold value related to the measurement value and a first sample amount threshold value related to the sample amount of the sample to be measured, the second measurement threshold value being lower than the first measurement threshold value. When the measurement value of the detection item obtained by the detection module 190 does not exceed the first measurement threshold but exceeds the second measurement threshold, the detection module 190 stores the sample size of the sample to be detected corresponding to the measurement value, when the measurement value obtained by the detection module 190 again exceeds the second threshold, the sample size of the sample to be detected corresponding to the measurement value is accumulated with the last sample size to obtain a first accumulated sample size, when the first accumulated sample size is greater than or equal to the first sample size threshold, the comparison module 194 judges that the residual amount of the reactant exceeds the standard, otherwise, the residual amount of the reactant does not exceed the standard. For example, the first measurement threshold is 500, the second measurement threshold is 300, the first sample amount threshold is 100ul, the measurement value of the detection item obtained by the detection module for a certain sample to be detected is 400, the detection module 190 stores the sample amount of the sample to be detected corresponding to the measurement value of 3ul, when the sample analyzer continues to analyze the sample to be detected, the measurement value exceeding 300 occurs again, the detection module 190 stores the data of the sample amount corresponding to the measurement value, for example, 5ul, and accumulates to obtain the first accumulated sample amount of 8ul, and so on, if the first accumulated sample amount exceeds 100ul, the comparison module 194 determines that the residual reactant amount exceeds the standard. It is understood that the sample amount may be referred to as a reference amount, and since the sample amount of each time of the sample analyzer may be fixed or slightly different, or the precision requirement on the cleaning control is not high, the sample amount of each time may be represented by 1, and the first sample amount threshold may be set to 50.
In another embodiment, the setting module 192 may also set a second sample size threshold related to the sample size of the sample to be tested after the test items are completed, the detecting module 190 obtains and stores the sample size of the sample to be tested corresponding to the measurement value of each test item, counts the accumulated values of the sample sizes to obtain a second accumulated sample size, when the second accumulated sample size is greater than or equal to the second sample size threshold, the comparing module 194 determines that the residual amount of the reactant exceeds the threshold, and when the second accumulated sample size is less than the set second sample size threshold, the comparing module 194 determines that the residual amount of the reactant does not exceed the threshold. Alternatively, in other embodiments, the setting module 192 sets a third measurement threshold related to the measured value, the detecting module 190 obtains and stores the measured value of each detection item, counts the cumulative value of the measured values, the comparing module 194 determines that the residual amount of the reactant exceeds the threshold when the cumulative value is greater than or equal to the third measurement threshold, and the comparing module 194 determines that the residual amount of the reactant does not exceed the threshold when the cumulative value of the measured value is less than the set third measurement threshold.
It will be appreciated by those skilled in the art that the protocols set forth in the foregoing examples may be used alone or in combination to determine if the reactant residue is out of tolerance.
The execution module 196 is connected to the comparison module 194 and the detection module 190, and is used for controlling the liquid transmission device 15 to draw the cleaning liquid from the cleaning liquid storage tank 14 according to the judgment result of the comparison module 194 to execute the cleaning operation. When the judgment result of the comparison module 194 is that the residual amount of the reactant exceeds the predetermined value, an execution instruction is issued to the execution module 196, and the execution module 196 receives the execution instruction and controls the liquid transfer device 15 to draw the cleaning liquid from the cleaning liquid storage tank 14 to clean the sample analyzer 1. When the judgment result of the comparing module 194 is that the reactant is not over-determined, a detection continuing instruction is sent to the detecting module 190, so the executing module 196 does not execute the operation, the detecting module 190 continues to acquire the detection parameters, and the comparing module 194 continues to compare the newly acquired detection parameters to continuously monitor the residual amount of the reactant. After each cleaning, the execution module 196 clears the detection parameters stored in the detection module 190 to prevent the residual reactant amount from being judged by mistake and the cleaning is repeated.
It will be appreciated that the cleaning of the sample analyzer 1 includes, in addition to the cleaning of the reaction cells 12, other parts of the sample analyzer 1, such as: the detector, the measurement channel and/or the sampling channel etc. are cleaned.
Second embodiment
As shown in fig. 2, a sample analyzer 2 according to a second embodiment of the present invention has substantially the same structure as the sample analyzer 1 according to the first embodiment of the present invention, except that: the liquid delivery device 25 includes a driver 250 and a liquid take-off tube 252. The driver 250 is connected to a liquid taking tube 252 for moving the liquid taking tube 252 to a predetermined position. The liquid take-off tube 252 is used to draw or release liquid. The execution module 196 of the cleaning controller 19 is connected to the driver 250, and is used for controlling the driver 250 to drive the liquid taking pipe 252 to draw the cleaning liquid from the cleaning liquid storage tank 14 to clean the sample analyzer 2 when the comparison module 194 judges that the residual amount of the reactant exceeds the standard.
The sample analyzer 1 provided by the embodiment of the invention judges the residual amount of the reactant according to the obtained detection parameters, and reasonably sets the cleaning time of the sample analyzer 1 according to the judgment, so that the cleaning times are reduced on the premise of ensuring that the residual amount of the reactant does not influence the detection result when the sample analyzer 1 is used for detection, the detection cost is reduced, and the detection efficiency is improved.
The application also discloses a cleaning control method of the sample analyzer, the sample analyzer is used for detecting detection items of a sample to be detected and reactants generated by a reaction reagent, and the sample analyzer comprises a sample suction device, a reaction tank, a detector, a cleaning solution storage tank and a liquid transmission device. The cleaning control method will be further described with reference to the sample analyzer 1 described above.
As shown in fig. 3, fig. 3 illustrates a cleaning control method according to an embodiment of the present invention, which includes the following steps:
and step S101, acquiring and storing the detection parameters of the detection items. The wash controller 19 obtains the detection parameters through a detection module 190. The detection parameters acquired by the detection module 190 include the measurement value of each detection of the detection item acquired by the detector 13 and/or the sample amount of the sample to be detected acquired by the sample-acquiring device 10. The detection parameters acquired by the detection module 190 are stored in a designated area of the memory 17 in order. One skilled in the art will appreciate that the sample size may also be obtained from the host system of the sample analyzer.
Step S102, comparing the acquired detection parameter with a preset threshold. The sample analyzer 1 presets a threshold value related to the residual amount of the reactant through the setting module 192 of the purge controller 19. The threshold value can be input by the user through the human-computer interaction device 16, or can be pre-stored in the memory 17 for the user to call. The set threshold value comprises a first measurement threshold value or a second measurement threshold value related to the measurement value of the detection item in the detection item, a first sample volume threshold value or a second sample volume threshold value related to the sample volume of the sample to be measured, or a third measurement threshold value related to the accumulated total number of the measurement values measured for multiple times in the detection item. It is understood that, for the same detection item, the second measurement threshold may be a plurality of different values lower than the first measurement threshold, and each second measurement threshold corresponds to a first sample amount threshold to determine the residual amount of the reactant. And for different detection items, the first measurement threshold, the second sample size threshold and the third measurement threshold can be adjusted adaptively due to different generated reactants.
The acquired detection parameters are compared with at least one preset threshold value.
In one embodiment, the acquired measurement value of the detection item may be compared as the detection parameter with a first measurement threshold.
In another embodiment, a measurement value of the detection item and a sample size of the to-be-detected sample corresponding to the measurement value are obtained, when the measurement value exceeds a second measurement threshold, an accumulated value of the sample size of the to-be-detected sample corresponding to the measurement value is counted to obtain a first accumulated sample size, and the first accumulated sample size is compared with a first sample size threshold. Preferably, the second measurement threshold is lower than the first measurement threshold.
In another embodiment, the sample size of the sample to be tested of the completed test item is obtained, the cumulative value of the sample sizes of the sample to be tested of the completed test item is counted to obtain a second cumulative sample size, and the second cumulative sample size is compared with the second sample size threshold. Preferably, the second sample size threshold may be higher or lower than the first sample size threshold.
In one embodiment, the accumulated value of the acquired measurement values of the detection items is counted, and the accumulated value is compared with a third measurement threshold.
And step S103, judging whether the residual quantity of the reactant exceeds the standard or not according to the comparison result. The sample analyzer 1 determines whether the residual amount of the reactant exceeds the standard or not according to a preset determination condition through the comparison module 194 of the cleaning controller 19 according to the comparison result. The judgment conditions include, but are not limited to: when the obtained measurement value is greater than or equal to the set first measurement threshold, the comparing module 194 determines that the residual amount of the reactant exceeds the standard, and when the obtained measurement value is less than the set first measurement threshold, the comparing module 194 determines that the residual amount of the reactant does not exceed the standard; when the first cumulative sample size exceeding the second measurement threshold is greater than or equal to the first sample size threshold, the comparing module 194 judges that the residual quantity of the reactant exceeds the standard, otherwise, judges that the residual quantity of the reactant does not exceed the standard; when the second cumulative sample size of the completed detection item is greater than or equal to the set second sample size threshold, the comparing module 194 determines that the residual amount of the reactant exceeds the standard, otherwise, determines that the residual amount of the reactant does not exceed the standard; the comparing module 194 determines that the residual amount of the reactant is out of limits when the obtained cumulative value of the measured values is greater than or equal to the set third measurement threshold, and determines that the residual amount of the reactant is not out of limits when the obtained cumulative value of the measured values is less than the set third measurement threshold.
The user can select one of the sets of determination conditions to determine the residual amount of the reactant. The user can also use multiple sets of judgment conditions to judge at the same time, and when any one of the conditions is formed, the comparison module 194 can judge the residual amount of the current reactant.
And step S104, if the residual quantity of the reactant exceeds the standard, controlling the liquid transmission device 15 to draw the cleaning liquid from the cleaning liquid storage tank 14 to clean the sample analyzer 1. And when the judgment result of the comparison module 194 is that the residual quantity of the reactant exceeds the standard, an execution instruction is sent to the execution module 196, and the execution module 196 receives the execution instruction and then controls the liquid transmission device 15 to draw the cleaning liquid from the cleaning liquid storage tank 14 to clean the reaction tank 12.
And if the residual quantity of the reactant is judged not to exceed the standard, returning to the step S101 to continuously obtain new detection parameters, and repeating the steps S101 to S104 until the residual quantity of the reactant is detected to exceed the standard, so that the residual quantity of the reactant can be continuously monitored.
Step S105, after the cleaning operation, the stored detection parameters are cleared, namely after the cleaning operation, each accumulated value is counted again to prevent the residual quantity of the reactants from being judged by mistake and the cleaning is repeated.
The sample analyzer 1 and the cleaning control method applied to the sample analyzer 1 judge the residual amount of the reactant according to the obtained detection parameters, and reasonably set the cleaning time of the sample analyzer 1 according to the judgment, so that the cleaning times are reduced on the premise of ensuring that the residual amount of the reactant does not influence the detection result when the sample analyzer 1 performs detection, the detection cost is reduced, and the detection efficiency is improved.
Although the present invention has been described with reference to the above embodiments, it should be understood that various changes and modifications can be made therein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (13)
1. A sample analyzer comprises a sample suction device, a reaction tank, a detector, a cleaning solution storage tank, a liquid transmission device and a cleaning controller, wherein the sample suction device sucks and conveys a sample to be detected to the reaction tank for measurement reaction, the detector detects a detection item of a reactant generated by the measurement reaction, cleaning solution is stored in the cleaning solution storage tank, the cleaning controller is respectively connected with the sample suction device and the detector to obtain a detection parameter, judges whether the residual reactant exceeds the standard or not according to the detection parameter, and controls the liquid transmission device to suck the cleaning solution from the cleaning solution storage tank to execute cleaning operation when the residual reactant exceeds the standard;
the acquired detection parameters comprise a measurement value of a detection item and a sample size of a sample to be detected corresponding to the measurement value, the set threshold comprises a first measurement threshold related to the measurement value of the detection item, a second measurement threshold and a first sample size threshold related to the sample size of the sample to be detected, the first measurement threshold is larger than the second measurement threshold, when the measurement value of the detection item is between the first measurement threshold and the second measurement threshold, the cleaning controller accumulates the sample size of the sample to be detected corresponding to the measurement value to obtain a first accumulated sample size, and when the first accumulated sample size is larger than or equal to the first sample size threshold, the cleaning controller judges that the residual quantity of the reactant exceeds a standard and controls the liquid transmission device to draw the cleaning liquid from the cleaning liquid storage tank to execute the cleaning operation.
2. The sample analyzer of claim 1, wherein: the cleaning controller comprises a detection module, a setting module, a comparison module and an execution module, wherein the detection module acquires and stores the detection parameters, the setting module is used for setting a threshold value related to the residual quantity of the reactants, the comparison module is connected with the detection module and the setting module and is used for comparing the acquired detection parameters with the set threshold value to judge whether the residual quantity of the reactants exceeds the standard or not, and the execution module is connected with the comparison module and is used for executing the cleaning operation according to the result of the comparison module.
3. The sample analyzer of claim 2, wherein: the system also comprises a human-computer interaction device, wherein the human-computer interaction device is connected with the setting module, and a user presets or adjusts the threshold value related to the residual quantity of the reactant through the human-computer interaction device.
4. The sample analyzer of claim 2, wherein: the acquired detection parameters are the measurement values of the detection items, the set threshold comprises a first measurement threshold related to the measurement values of the detection items, when the measurement values acquired by the detection module are greater than or equal to the first measurement threshold, the comparison module judges that the residual quantity of the reactant exceeds the standard, and the execution module controls the liquid transmission device to draw the cleaning liquid from the cleaning liquid storage tank to execute the cleaning operation.
5. The sample analyzer of claim 2, wherein: the acquired detection parameters comprise the sample size of a sample to be detected of which the detection item is finished, the set threshold comprises a second sample size threshold related to the sample size of the sample to be detected of which the detection item is finished, the detection module accumulates the sample size of the sample to be detected of which the detection item is finished to obtain a second accumulated sample size, when the second accumulated sample size is larger than or equal to the second sample size threshold, the comparison module judges that the residual quantity of the reactant exceeds the standard, and the execution module controls the liquid transmission device to draw the cleaning liquid from the cleaning liquid storage tank to execute the cleaning operation.
6. The sample analyzer of claim 2, wherein: the acquired detection parameters comprise measurement values of detection items, the set threshold comprises a third measurement threshold related to the detection items, the detection module counts an accumulated value of the measurement values of the detection items, when the accumulated value is larger than or equal to the third measurement threshold, the comparison module judges that the residual quantity of the reactant exceeds the standard, and the execution module controls the liquid transmission device to draw the cleaning liquid from the cleaning liquid storage tank to execute the cleaning operation.
7. The sample analyzer of claim 2, wherein: after the cleaning operation is executed, the execution module clears the detection parameters stored by the detection module before the cleaning operation.
8. The sample analyzer of claim 1, wherein: the sample analyzer includes a reagent tank, the wash solution is a hemolytic agent stored in the wash solution storage tank or in the reagent tank.
9. A cleaning control method of a sample analyzer, the sample analyzer is used for detecting detection items of reactants generated by a sample to be detected and a reaction reagent, and at least one threshold value related to the residual quantity of the reactants is set, the cleaning control method comprises the following steps:
acquiring and storing detection parameters of detection items, wherein the acquired detection parameters comprise measurement values of the detection items and sample sizes of samples to be detected corresponding to the measurement values;
comparing the obtained detection parameters with preset thresholds, wherein the thresholds comprise a first measurement threshold, a second measurement threshold and a first sample volume threshold related to the sample volume of a sample to be detected, which are measured in a detection item, the first measurement threshold is larger than the second measurement threshold, when the measurement value of the detection item is between the first measurement threshold and the second measurement threshold, the cleaning controller accumulates the sample volume of the sample to be detected corresponding to the measurement value to obtain a first accumulated sample volume, and the first accumulated sample volume is compared with the first sample volume threshold to obtain a comparison result;
judging whether the residual quantity of the reactants exceeds the standard or not according to the comparison result, judging that the residual quantity of the reactants exceeds the standard when the first accumulated sample quantity is larger than or equal to the first sample quantity threshold, and judging that the residual quantity of the reactants does not exceed the standard when the first accumulated sample quantity is smaller than the first sample quantity threshold;
and if the residual quantity of the reactant exceeds the standard, cleaning the sample analyzer.
10. The cleaning control method according to claim 9, characterized in that: the acquired detection parameters are the measurement values of the detection items, the threshold values comprise a first measurement threshold value related to the measurement values of the detection items, and when the acquired measurement values are greater than or equal to the set first measurement threshold value, the residual reactant quantity is judged to be over-standard.
11. The cleaning control method according to claim 9, characterized in that: the obtained detection parameters comprise the sample size of the sample to be detected of which the detection item is finished, the threshold comprises a second sample size threshold, the accumulated value of the sample size of the sample to be detected of which the detection item is finished is counted to obtain a second accumulated sample size, and when the second accumulated sample size is larger than or equal to the second sample size threshold, the residual quantity of the reactant is judged to be over-standard.
12. The cleaning control method according to claim 9, characterized in that: the acquired detection parameters comprise the measurement values of the detection items, the threshold comprises a third measurement threshold related to the detection items, the accumulated value of the measurement values of the detection items is counted, and when the accumulated value is larger than or equal to the third measurement threshold, the residual quantity of the reactants is judged to be over standard.
13. The cleaning control method according to claim 9, characterized in that: and after the cleaning operation, clearing the stored detection parameters.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610581147.3A CN107643410B (en) | 2016-07-21 | 2016-07-21 | Sample analyzer and cleaning control method for sample analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610581147.3A CN107643410B (en) | 2016-07-21 | 2016-07-21 | Sample analyzer and cleaning control method for sample analyzer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107643410A CN107643410A (en) | 2018-01-30 |
| CN107643410B true CN107643410B (en) | 2021-04-02 |
Family
ID=61109783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610581147.3A Active CN107643410B (en) | 2016-07-21 | 2016-07-21 | Sample analyzer and cleaning control method for sample analyzer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107643410B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020020169A1 (en) * | 2018-07-23 | 2020-01-30 | 深圳市帝迈生物技术有限公司 | Sample analyzing device and cleaning method thereof |
| JP6800193B2 (en) * | 2018-09-28 | 2020-12-16 | シスメックス株式会社 | Specimen analyzer, sample analysis method and program |
| CN111855977B (en) * | 2019-04-30 | 2021-12-14 | 深圳市帝迈生物技术有限公司 | Blood analysis system, cleansing liquid calculation device, and cleansing liquid calculation method |
| EP3971577A4 (en) * | 2019-05-13 | 2023-03-29 | Hitachi High-Tech Corporation | Automatic analysis apparatus and cleaning method for same |
| CN110865018B (en) * | 2019-08-08 | 2023-03-28 | 上海交通大学医学院附属新华医院 | Sample post-processing system, device and method |
| CN112444467B (en) * | 2019-09-05 | 2024-08-13 | 深圳迈瑞动物医疗科技股份有限公司 | Cleaning method, blood cell analyzer and storage medium |
| CN112578133B (en) * | 2019-09-27 | 2024-07-05 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analysis system and test management method of analysis equipment |
| CN112904036B (en) * | 2019-12-03 | 2024-02-06 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid supply system and method thereof |
| CN112557447B (en) * | 2020-11-23 | 2023-06-16 | 深圳市科曼医疗设备有限公司 | Specific protein analysis method and control device based on blood cell analyzer |
| CN115524504A (en) * | 2021-06-25 | 2022-12-27 | 深圳市帝迈生物技术有限公司 | Sample analysis device, cleaning method thereof and computer-readable storage medium |
| CN114618853A (en) * | 2022-05-11 | 2022-06-14 | 深圳市帝迈生物技术有限公司 | Cleaning method of sample analyzer and sample analyzer |
| CN114791502B (en) * | 2022-06-13 | 2022-10-28 | 深圳市帝迈生物技术有限公司 | Sample detection method and sample analyzer |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011112502A (en) * | 2009-11-26 | 2011-06-09 | Beckman Coulter Inc | Autoanalyzer and washing method |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001041964A (en) * | 1999-07-30 | 2001-02-16 | Olympus Optical Co Ltd | Autoanalyzer |
| EP1813950B1 (en) * | 2006-01-30 | 2011-05-18 | Kabushiki Kaisha Toshiba | Autoanalyzer with variable probe cleaning |
| JP4805710B2 (en) * | 2006-03-31 | 2011-11-02 | シスメックス株式会社 | Sample analyzer |
| JP6505439B2 (en) * | 2012-12-05 | 2019-04-24 | 株式会社日立ハイテクノロジーズ | Automatic analyzer |
| US9933447B2 (en) * | 2013-04-18 | 2018-04-03 | Hitachi High-Technologies Corporation | Automatic analyzing device |
| CN205027766U (en) * | 2015-09-11 | 2016-02-10 | 重庆医科大学附属永川医院 | Arena analysis appearance |
-
2016
- 2016-07-21 CN CN201610581147.3A patent/CN107643410B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011112502A (en) * | 2009-11-26 | 2011-06-09 | Beckman Coulter Inc | Autoanalyzer and washing method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107643410A (en) | 2018-01-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107643410B (en) | Sample analyzer and cleaning control method for sample analyzer | |
| JP5865633B2 (en) | Automatic analyzer | |
| CN105547754B (en) | A kind of water quality equal proportion mixing sampling and over-standard sample retention system and method | |
| CN113811773B (en) | Automatic analysis device and cleaning method thereof | |
| JP6602753B2 (en) | Automatic analyzer | |
| WO2014119525A1 (en) | Automated analysis device | |
| WO2014013836A1 (en) | Automatic analysis device | |
| CN110749729A (en) | Sample analyzer and cleaning method thereof | |
| CN110383075B (en) | automatic analysis device | |
| US10948388B2 (en) | Smear preparation apparatus, blood sample processing system, and method of washing blood processing unit of the smear preparation apparatus | |
| US20140186234A1 (en) | Automatic analysis apparatus | |
| JP6654881B2 (en) | Automatic analyzer and method for determining abnormality of automatic analyzer | |
| CN108431599B (en) | Method for detecting the presence of a clot in a liquid sample analyzer | |
| JP2004271266A (en) | Dispensing device and autoanalyzer using the same | |
| CN105738287A (en) | Water quality analyzer | |
| CN108120845A (en) | Automatic analyzer, sampling probe imbibition control method and control system | |
| JP2000121645A (en) | Automatic analyzer having means for monitoring pipette operation | |
| CN114062205A (en) | Blood cell analyzer and cleaning method thereof | |
| JP2013217740A (en) | Automatic analyzer | |
| US8936765B2 (en) | Automatic analyzer | |
| CN112147186B (en) | Specific protein analysis method and control device based on blood cell analyzer | |
| CN113466473A (en) | Sample analyzer and sample analysis method and system | |
| CN114563586A (en) | Blood analyzer, abnormality detection method for blood analyzer, and computer-readable storage medium | |
| CN116499949A (en) | Sample analyzer and fault diagnosis method | |
| CN105891284A (en) | Novel electrolyte analyzer and analysis method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |