CN114798614B - Cleaning device and cleaning method for sample analyzer and sample analyzer - Google Patents
Cleaning device and cleaning method for sample analyzer and sample analyzer Download PDFInfo
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- CN114798614B CN114798614B CN202210742796.2A CN202210742796A CN114798614B CN 114798614 B CN114798614 B CN 114798614B CN 202210742796 A CN202210742796 A CN 202210742796A CN 114798614 B CN114798614 B CN 114798614B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B9/00—Cleaning hollow articles by methods or apparatus specially adapted thereto
- B08B9/02—Cleaning pipes or tubes or systems of pipes or tubes
- B08B9/027—Cleaning the internal surfaces; Removal of blockages
- B08B9/032—Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B13/00—Accessories or details of general applicability for machines or apparatus for cleaning
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Abstract
The application provides a cleaning device and a cleaning method of a sample analyzer and the sample analyzer. The cleaning device comprises a cleaning liquid supplementing portion, a waste liquid discharging portion, a first three-way control assembly, a first driving piece and a portion to be cleaned, wherein when the first end of the first three-way control assembly is communicated with the second end of the first three-way control assembly, the first driving piece can be used for injecting the cleaning liquid into the portion to be cleaned through the first three-way control assembly and a pipeline between the portions to be cleaned, and the waste liquid discharging portion is used for discharging liquid in the portion to be cleaned through the pipeline between the portion to be cleaned and the first three-way control assembly. The cleaning device is simple in structure, and can achieve repeated cleaning of the pipeline between the cleaning portion and the first three-way control assembly, and therefore the cleaning effect can be improved.
Description
Technical Field
The application relates to the technical field of medical instruments, in particular to a cleaning device of a sample analyzer, a cleaning method of the cleaning device and the sample analyzer.
Background
The sample analyzer is a medical precision instrument, can be used for analyzing and measuring blood samples, and has the following general working processes: sucking a quantitative sample, pumping the sample into a reaction tank according to a preset dilution ratio by using a quantitative reagent, uniformly mixing and reacting in the reaction tank, and then sampling and measuring parameters. The sample analyzer needs to be filled with cleaning fluid to perform daily/periodic cleaning of the fluid path. So that the next measurement is not affected by the last measurement.
At present, some pipelines and reaction cells of some detection items need to be contacted with blood samples and strongly-adhesive reagents, such as latex reagents, fluorescent reagents and the like, so that the requirement on cleaning is high.
However, in the prior art, the cleaning effect of the sample analyzer is not good, and the problem of carrying pollution may be brought.
Disclosure of Invention
The application provides a cleaning device of a sample analyzer, a cleaning method of the cleaning device and the sample analyzer, and aims to solve the technical problems that in the prior art, the cleaning effect of the sample analyzer is poor, and the carrying pollution problem is possibly caused.
In order to solve the technical problem, the application adopts a technical scheme that: there is provided a cleaning device for a sample analyzer, the cleaning device comprising: the cleaning device comprises a cleaning liquid supplementing part, a waste liquid discharging part, a first three-way control assembly, a first driving part and a part to be cleaned, wherein the first end of the first three-way control assembly is connected with the first end of the part to be cleaned, the second end of the first three-way control assembly is connected with the cleaning liquid supplementing part, the third end of the first three-way control assembly of the first three-way assembly is connected with the waste liquid discharging part, the cleaning liquid supplementing part is connected with the first driving part, the first driving part is used for injecting the cleaning liquid sucked in the cleaning liquid supplementing part into the part to be cleaned, when the first end of the first three-way control assembly is communicated with the second end of the first three-way control assembly, the first driving part is further used for injecting the sucked cleaning liquid supplementing part into the part to be cleaned through a pipeline between the first three-way control assembly and the part to be cleaned, when the first end of the first three-way control assembly is communicated with the third end of the first three-way control assembly, the waste liquid discharging part is used for discharging the liquid discharged from the part to be cleaned through the pipeline between the part to be cleaned and the third end of the third three-way control assembly, and the part to be cleaned.
In order to solve the above technical problem, another technical solution adopted by the present application is: there is provided a method for cleaning a sample analyzer, the method for cleaning a sample analyzer, based on the cleaning apparatus of any one of the above embodiments, including: controlling the first end of the first three-way control assembly to be communicated with the second end of the first three-way control assembly; cleaning liquid is injected into the part to be cleaned through the first driving piece and the cleaning liquid supplementing part through a pipeline between the first three-way control assembly and the part to be cleaned; controlling the first end of the first three-way control assembly to be communicated with the third end of the first three-way control assembly; and liquid in the part to be cleaned is discharged through a pipeline between the part to be cleaned and the first three-way control assembly through the waste liquid discharge part, so that repeated cleaning of the part to be cleaned and the pipeline between the part to be cleaned and the first three-way control assembly is realized through alternate communication of the first end of the first three-way control assembly, the second end of the first three-way control assembly and the third end of the first three-way control assembly.
In order to solve the above technical problem, another technical solution adopted by the present application is: there is provided a sample analyzer comprising: the cleaning device of any of the above embodiments.
The beneficial effect of this application is: be different from prior art's condition, the belt cleaning device of this application includes washing liquid supplement portion, waste liquid discharge portion, first tee control subassembly, first driving piece and treats the cleaning part, when first tee control subassembly's first end and first tee control subassembly's second end intercommunication, first driving piece can be used for treating the cleaning part with the washing liquid via first tee control subassembly with treat the pipeline injection between the cleaning part, waste liquid discharge portion is used for treating the liquid in the cleaning part through treating the pipeline discharge between cleaning part and the first tee control subassembly. The cleaning device is simple in structure, can realize treating the cleaning part and the repeated cleaning of the pipeline between the cleaning part and the first tee control assembly, thereby improving the cleaning effect, and having good cleaning effect on some reagents with strong adhesion, such as latex reagents, fluorescent reagents and the like.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, it is obvious that the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without inventive efforts, wherein:
FIG. 1 is a schematic block diagram of one embodiment of a cleaning device and a detection assembly of a sample analyzer provided herein;
FIG. 2 is a schematic flow chart diagram of one embodiment of a method for cleaning a sample analyzer provided herein;
FIG. 3 is a flowchart illustrating an embodiment of step S12 in FIG. 2;
FIG. 4 is a schematic diagram of another embodiment of a cleaning device and a detection assembly of the sample analyzer provided herein.
Detailed Description
The technical solutions in the embodiments of the present application will be described clearly and completely with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only some embodiments of the present application, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
It should be noted that, if directional indications (such as up, down, left, right, front, and back … …) are involved in the embodiment of the present application, the directional indications are only used to explain the relative position relationship between the components, the motion situation, and the like in a specific posture (as shown in the drawing), and if the specific posture is changed, the directional indications are changed accordingly.
In addition, if there is a description of "first", "second", etc. in the embodiments of the present application, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of the feature. In addition, technical solutions between the embodiments may be combined with each other, but must be based on the realization of the technical solutions by a person skilled in the art, and when the technical solutions are contradictory to each other or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope claimed in the present application.
The present application provides a sample analyzer, as shown in fig. 1, the sample analyzer 10 includes a washing device 101 and a detection assembly (not shown), which are described in detail below with reference to the washing device 101 and the detection assembly.
This cleaning device 101 includes: a cleaning liquid replenishing part 11, a waste liquid discharging part 12, a first three-way control assembly 13, a first driving part 111 and a part to be cleaned 14.
The first end of the first three-way control assembly 13 is connected with the first end of the to-be-cleaned part 14, the second end of the first three-way control assembly 13 is connected with the cleaning liquid supplementing part 11, the third end of the first three-way control assembly 13 is connected with the waste liquid discharging part 12, and the cleaning liquid supplementing part 11 is connected with the first driving part 111. The first driver 111 may be used to inject the cleaning liquid in the cleaning liquid replenishing portion 11 into the portion to be cleaned 14, and the waste liquid discharging portion 12 may be used to discharge the liquid in the portion to be cleaned 14.
Specifically, when the first end of the first three-way control assembly 13 is communicated with the second end of the first three-way control assembly 13, the first driving element 111 may be configured to inject the cleaning liquid into the portion to be cleaned 14 through the pipeline T1 between the first three-way control assembly 13 and the portion to be cleaned 14, and when the first end of the first three-way control assembly 13 is communicated with the third end of the first three-way control assembly 13, the waste liquid discharge portion 12 is configured to discharge the liquid in the portion to be cleaned 14 through the pipeline T1 between the portion to be cleaned 14 and the first three-way control assembly 13. So as to realize the repeated cleaning of the pipeline T1 between the part to be cleaned 14 and the first three-way control assembly 13 through the alternate communication of the first end of the first three-way control assembly 13 and the second end of the first three-way control assembly 13 as well as the first end of the first three-way control assembly 13 and the third end of the first three-way control assembly 13.
Based on the cleaning device 101 of the above embodiment, as shown in fig. 2, in an embodiment, the cleaning method of the sample analyzer includes:
s11: the first end of the first three-way control component is controlled to be communicated with the second end of the first three-way control component.
S12: and the first driving piece and the cleaning liquid supplementing part inject the cleaning liquid into the part to be cleaned through a pipeline between the first three-way control assembly and the part to be cleaned.
S13: and the first end of the first three-way control assembly is controlled to be communicated with the third end of the first three-way control assembly.
S14: and liquid in the part to be cleaned is discharged through a pipeline between the part to be cleaned and the first three-way control assembly through the waste liquid discharge part, so that repeated cleaning of the part to be cleaned and the pipeline between the part to be cleaned and the first three-way control assembly is realized through alternate communication of the first end of the first three-way control assembly, the second end of the first three-way control assembly and the third end of the first three-way control assembly.
According to the cleaning method, by repeatedly cleaning the part to be cleaned 14 and the pipeline T1 between the part to be cleaned 14 and the first three-way control assembly 13, the cleaning effect of the part to be cleaned 14 and the pipeline T1 can be enhanced, and the cleaning method has a good cleaning effect on a reagent with strong adhesion.
Alternatively, the waste liquid discharge part 12 may also be used to suck the liquid in the part to be cleaned 14 into the pipeline T1 between the first three-way control assembly 13 and the part to be cleaned 14. The cleaning liquid in the pipeline T1 between the first three-way control assembly 13 and the portion to be cleaned 14 is injected into the portion to be cleaned 14 through the first driving member 111, and the liquid in the portion to be cleaned 14 is sucked into the pipeline T1 between the first three-way control assembly 13 and the portion to be cleaned 14 through the waste liquid discharge portion 12, so that the cleaning liquid moves back and forth in the portion to be cleaned 14 and the pipeline T1 between the portion to be cleaned 14 and the first three-way control assembly 13, and the portion to be cleaned 14 and the pipeline T1 are cleaned in a reciprocating manner. In this way, the cleaning effect of the portion to be cleaned 14 and the pipeline T1 can be further enhanced.
Further, as shown in fig. 1, the cleaning device 101 may further include a second three-way control assembly 113. A first end of the second three-way control assembly 113 is connected to the first driving member 111, a second end of the second three-way control assembly 113 is connected to the cleaning liquid replenishing portion 11, and a third end of the second three-way control assembly 113 is connected to a second end of the first three-way control assembly 13. The first driver 111 is capable of extracting the cleaning liquid from the cleaning liquid replenishing portion 11 and injecting the extracted cleaning liquid into the portion-to-be-cleaned 14.
Specifically, when the first end of the second three-way control assembly 113 is communicated with the second end of the second three-way control assembly 113, the first driving element 111 is used for sucking the cleaning liquid from the cleaning liquid replenishing portion 11, and when the first end of the second three-way control assembly 113 is communicated with the third end of the second three-way control assembly 113, the first driving element 111 is used for driving the sucked cleaning liquid into the portion to be cleaned 14 through the pipeline T1 between the first three-way control assembly 13 and the portion to be cleaned 14.
In a specific embodiment, as shown in fig. 3, the step of injecting the cleaning liquid into the portion to be cleaned 14 through the first driving member 111 and the cleaning liquid supplementing portion 11 via the pipeline T1 between the first three-way control assembly 13 and the portion to be cleaned 14 includes:
s121: and the first end of the second three-way control component is controlled to be communicated with the second end of the second three-way control component.
S122: and the cleaning liquid is sucked from the cleaning liquid replenishing portion by the first driving member.
S123: and the first end of the second three-way control component is controlled to be communicated with the third end of the second three-way control component.
S124: and the first driving piece injects the sucked cleaning liquid into the part to be cleaned through a pipeline between the first three-way control component and the part to be cleaned.
In the embodiment shown in fig. 1, the first drive member 111 is a syringe. When the first end of the second three-way control component 113 is communicated with the second end of the second three-way control component 113, the injector is used for sucking a certain amount of cleaning liquid from the cleaning liquid supplementing part 11, and when the first end of the second three-way control component 113 is communicated with the third end of the second three-way control component 113, the injector is used for injecting the sucked cleaning liquid into the part to be cleaned 14 through a pipeline T1 between the first three-way control component 13 and the part to be cleaned 14. Optionally, the first driver 111 may also be a fixed displacement pump. The fixed displacement pump can also be used to suck up a fixed amount of the cleaning liquid from the cleaning liquid replenishing portion 11 and to inject the sucked-up cleaning liquid into the portion-to-be-cleaned 14 via the piping T1. In other embodiments, the first driver 111 may further comprise a positive pressure source and a negative pressure source, which may be switched by a control valve.
Optionally, the first three-way control assembly 13 and the second three-way control assembly 113 may be three-way control valves, or the first three-way control assembly 13 and the second three-way control assembly 113 may further include a three-way joint and two control valves, and the two control valves are respectively used for controlling on/off of the two passages.
The first driving member 111 can also be used to mix the liquid to be detected in the portion 14 to be cleaned, which will be described below.
Above-mentioned cleaning device 101 not only can treat cleaning portion 14 and treat pipeline T1 between cleaning portion 14 and the first tee bend control assembly 13 and wash, can also utilize first driving piece 111 to treat the liquid of waiting to detect in cleaning portion 14 and carry out the mixing, so, can improve sample analyzer testing result's reliability, in addition, come to carry out the mixing to the sample through the part in the belt cleaning device 101 of sharing, need not to set up other mixing parts, can simplify sample analyzer 10's overall structure, practice thrift the hardware cost.
As shown in fig. 1, the waste liquid discharge portion 12 may include a second driving member 121 and a waste liquid collecting tank 122, the second driving member 121 is connected to a first end of the waste liquid collecting tank 122, a second end of the waste liquid collecting tank 122 is connected to a third end of the first three-way control component 13, and the second driving member 121 is configured to suck the liquid in the portion to be cleaned 14 into the waste liquid collecting tank 122 through a pipeline T1 between the portion to be cleaned 14 and the first three-way control component 13. Further, the second driving member 121 may be connected to the waste liquid collecting tank 122 through a control valve 123. The control valve 123 is used for controlling the communication and closing between the second driving member 121 and the waste liquid collecting tank 122.
A liquid outlet (not shown) may be disposed at the bottom of the waste liquid collecting tank 122, and a valve (not shown) and a negative pressure source (not shown) are disposed at the liquid outlet, so that the waste liquid in the waste liquid collecting tank 122 can be discharged through the valve and the negative pressure source.
The waste liquid discharge portion 12 can suck out the liquid in the portion-to-be-cleaned 14. In this embodiment, the step of discharging the liquid in the portion-to-be-cleaned 14 through the waste liquid discharge portion 12 includes: the liquid in the portion to be cleaned 14 is sucked into the waste liquid collecting tank 122 by the second driving member 121. Specifically, the second driving member 121 sucks the liquid in the portion to be cleaned 14 to the waste liquid collecting tank 122 through the pipe T1 and the pipe T3. In this way, the cleaning liquid can be made to flow in the reverse direction in the portion to be cleaned 14 and the pipeline T1 to perform the reverse cleaning of the portion to be cleaned 14 and the pipeline T1, thereby improving the cleaning effect. Wherein, the reverse direction represents the direction of the part to be cleaned towards the waste liquid collecting tank along the liquid path.
Specifically, the cleaning of the portion to be cleaned 14 and the pipeline T1 between the portion to be cleaned 14 and the first three-way control assembly 13 can be achieved by alternately performing the operations of injecting the cleaning liquid into the portion to be cleaned 14 through the pipeline T2 and the pipeline T1 and sucking the liquid in the portion to be cleaned 14 into the waste liquid collecting tank 122 through the pipeline T1 and the pipeline T3 by the first driving member 111 and repeatedly performing the operations of alternately performing the operations so as to make the cleaning liquid flow back and forth in the portion to be cleaned 14 and the pipeline T1, and in this way, the cleaning effect of the portion to be cleaned 14 and the pipeline T1 can be enhanced. It can be understood that, by repeating the above steps of injecting the cleaning liquid and sucking the cleaning liquid, the portion to be cleaned 14 and the pipeline T1 are cleaned for a plurality of times, so that the cleaning effect can be significantly improved, and the cleaning effect is good for some reagents with strong adhesion, such as latex reagents, fluorescent reagents, and the like.
Further, the second driving member 121 can also be used for sucking the liquid in the portion to be cleaned 14 into the pipeline T1 between the first three-way control assembly 13 and the portion to be cleaned 14. The cleaning liquid in the pipeline T1 between the first three-way control assembly 13 and the to-be-cleaned part 14 is injected into the to-be-cleaned part 14 through the first driving part 111, and the liquid in the to-be-cleaned part 14 is sucked into the pipeline T1 between the first three-way control assembly 13 and the to-be-cleaned part 14 through the second driving part 121, so that the cleaning liquid moves back and forth in the pipeline T1 between the to-be-cleaned part 14 and the first three-way control assembly 13, the to-be-cleaned part 14 and the pipeline T1 are cleaned back and forth, and the cleaning effect of the to-be-cleaned part 14 and the pipeline T1 is enhanced.
Alternatively, the waste liquid discharge portion 12 may be provided with a liquid pump or other waste liquid tank separately to complete the process of sucking up the liquid in the portion to be cleaned 14.
Further, as shown in fig. 1, the cleaning device 101 further includes a liquid draining portion 17, the liquid draining portion 17 is connected to the second end of the portion to be cleaned 14, and the liquid draining portion 17 is used for draining the liquid in the portion to be cleaned 14. The drain portion 17 may be connected to the second end of the portion-to-be-cleaned 14 through a control valve 171. The control valve 171 is used to control communication and closing between the drain portion 17 and the portion-to-be-cleaned 14. The drainage portion 17 may include a negative pressure source for sucking out the liquid in the portion to be washed 14. For example, after the sample is detected and before the washing apparatus 101 washes the part to be washed 14, the waste liquid from the detection in the part to be washed 14 can be sucked out through the drain 17.
The cleaning apparatus 101 of the above embodiment has a simple structure, and can make the cleaning liquid flow forward and backward between the portion to be cleaned 14 and the pipeline T1, so that the cleaning effect can be significantly improved, and a good cleaning effect can be achieved for a reagent having a strong adhesion property.
Further, as shown in FIG. 1, the detection assembly may include a reagent addition assembly 15 and a sample addition assembly 16.
The sample adding assembly 16 is used to add a sample to the portion to be cleaned 14. Specifically, the sample addition assembly 16 may include a driver 161 and a sampling needle 162, the driver 161 being connected to the sampling needle 162. When a sample is to be detected, the sample is sucked by the sampling needle 162, and the sample in the sampling needle 162 is injected into the portion to be cleaned 14 by the driving member 161. For example, the portion to be cleaned 14 includes a reaction cell, and a sample can be added to the reaction cell by the sample adding unit 16, and a reagent can be added to the reaction cell by the reagent adding unit 15, so that the reagent and the sample can be mixed in the reaction cell to form a liquid to be detected.
The reagent adding unit 15 may add different reagents to the portion to be cleaned 14 according to the items to be detected. For example, in the embodiment shown in FIG. 1, the reagent addition assembly 15 includes a hemolytic agent addition component (shown in FIG. 1 but not numbered) and an emulsion reagent addition component (shown in FIG. 1 but not numbered).
The hemolytic agent adding component comprises a driving component 151 and a hemolytic agent storage part 152, the driving component 151 is connected with the hemolytic agent storage part 152, and the driving component 151 is used for injecting hemolytic agent in the hemolytic agent storage part 152 into the part to be cleaned 14. The driving member 151 may be connected to the hemolytic agent storage portion 152 through a three-way control valve 155, specifically, the driving member 151 is connected to a first end of the three-way control valve 155, a second end of the three-way control valve 155 is connected to the hemolytic agent storage portion 152, and a third end of the three-way control valve 155 is connected to the portion to be washed 14. When the first end and the second end of the three-way control valve 155 are communicated, the driving member 151 extracts a predetermined amount of the hemolytic agent from the hemolytic agent storage portion 152, and when the first end and the third end of the three-way control valve 155 are communicated, the driving member 151 injects the extracted hemolytic agent into the portion-to-be-washed 14.
The emulsion reagent adding part comprises a driving part 153 and an emulsion reagent storage part 154, wherein the driving part 153 is connected with the emulsion reagent storage part 154 and is used for injecting the emulsion reagent in the emulsion reagent storage part 154 into the part to be cleaned 14. The driving member 153 may be connected to the latex reagent storage 154 through a three-way control valve 156, specifically, the driving member 153 is connected to a first end of the three-way control valve 156, a second end of the three-way control valve 156 is connected to the latex reagent storage 154, and a third end of the three-way control valve 156 is connected to the to-be-cleaned part 14. When the first end and the second end of the three-way control valve 156 are communicated, the driving member 153 extracts a predetermined amount of the emulsion reagent from the emulsion reagent storage portion 154, and when the first end and the third end of the three-way control valve 156 are communicated, the driving member 153 injects the extracted emulsion reagent into the portion to be cleaned 14.
Because the adhesion of latex reagent is very strong, the belt cleaning device 101 of this application also has better cleaning performance to latex reagent.
Among them, the driving member 151 and the driving member 153 may be a syringe or a quantitative pump, etc. to add a quantitative amount of reagent into the portion to be cleaned 14. The quantitative sucking of the hemolytic agent and the latex reagent may be realized by a reagent needle, that is, the reagent needle sucks a quantitative amount of the reagent from the reagent bottle and moves the reagent bottle into the portion to be cleaned 14 to add the reagent bottle.
By way of example, the detection process and the cleaning process of the sample analyzer 10 of the present application are as follows:
the method comprises the following steps: after the start of counting, the control valve 171 is opened to drain the portion to be cleaned 14 through the drain portion 17;
step two: opening the three-way control valve 155, and controlling the driving member 151 to add the hemolytic agent to the portion-to-be-cleaned 14; the sampling needle 162 moves to the part to be cleaned 14, and the driving part 161 is controlled to add the blood sample to the part to be cleaned 14; the second three-way control assembly 113 is opened, and the mixed solution of the hemolytic agent and the blood sample moves back and forth in the pipeline T1 and the part to be cleaned 14 through the first driving piece 111, so that the uniform mixing effect is achieved;
step three: opening the three-way control valve 156, and controlling the driving member 153 to add the latex reagent into the part to be cleaned 14; the second three-way control assembly 113 is opened, and the mixed solution of the latex reagent, the hemolytic agent and the blood sample moves back and forth in the pipeline T1 and the part to be cleaned 14 through the first driving piece 111, so that the uniform mixing effect is achieved, and counting is started;
step four: after the counting is finished, the first three-way control assembly 13 is opened, and liquid is sucked into the waste liquid collecting tank 122 from the pipeline T1 and the part to be cleaned 14; opening the second three-way control assembly 113, and controlling the first driving member 111 to add the cleaning liquid into the pipeline T1 and the part to be cleaned 14;
step five: opening the first three-way control assembly 13 to draw liquid from the conduit T1 and the portion to be cleaned 14 into the waste liquid collection tank 122;
step six: and repeating the fourth step and the fifth step, and finishing forward and reverse cleaning of the T1 pipeline and the part to be cleaned 14 for multiple times. Wherein, the forward direction represents the direction of the first driving member towards the part to be cleaned along the liquid path, and the reverse direction represents the direction of the part to be cleaned towards the waste liquid collecting tank along the liquid path.
The sample analyzer 10 of the present embodiment has a simple structure, and the cleaning device 101 can clean the portion to be cleaned 14 and the detection line to and fro a plurality of times, thereby improving the cleaning effect.
Referring to fig. 4, in the present embodiment, the sample analyzer 20 includes a cleaning device 201 and a detection assembly, and the cleaning device 201 includes a cleaning solution replenishing portion 21, a waste liquid discharging portion 22, a first three-way control assembly 23, a first driving member 211 and a portion to be cleaned 24. Different from the previous embodiment, in the present embodiment, the portion to be cleaned 24 includes a reaction tank 241 and a detection portion 242, the cleaning apparatus 201 further includes a third control valve 282 and a three-way joint 281, a first end of the third control valve 282 is connected to the reaction tank 241, a second end of the third control valve 282 is connected to a first interface of the three-way joint 281, a second interface of the three-way joint 281 is connected to the detection portion 242, and a third interface of the three-way joint 281 is connected to a first end of the first three-way control assembly 23.
In this embodiment, the first driving member 211 is further used for injecting the cleaning solution into the detecting portion 242 through the pipeline between the first three-way control assembly 23 and the detecting portion 242 and injecting the cleaning solution into the reaction cell 241 through the pipeline T1 between the first three-way control assembly 23 and the reaction cell 241.
The waste liquid discharging unit 22 is configured to discharge the liquid in the reaction cell 241 through the pipeline T1 between the reaction cell 241 and the first three-way control assembly 23, and the waste liquid discharging unit 22 is further configured to discharge the liquid in the detection unit 242 through the pipeline between the detection unit 242 and the first three-way control assembly 23, so as to achieve repeated cleaning of the reaction cell 241, the detection unit 242, the pipeline T1 between the reaction cell 241 and the first three-way control assembly 23, and the pipeline between the detection unit 242 and the first three-way control assembly 23 through the alternate communication of the first end of the first three-way control assembly 23, the three-way joint 281, the reaction cell 241 and the detection unit 242, and the first end of the first three-way control assembly 23.
Alternatively, the detection unit 242 and the reaction cell 241 may be cleaned at the same time, or the detection unit 242 and the reaction cell 241 may be cleaned separately.
Specifically, please refer to the description of the embodiment shown in fig. 1 for a process of separately cleaning the reaction cell 241 and the pipeline T1 between the reaction cell 241 and the first three-way control assembly 23 and a process of uniformly mixing the reagent and the sample in the reaction cell 241 through the first driving member 211, which is not described herein again. In the above cleaning and blending process, the valve in the detecting part 242 may be closed to ensure the flow direction of the liquid. The cleaning process of the detecting part 242 will be specifically described below.
When the detection part 242 is cleaned alone, the third control valve 282 is closed, the first end and the second end of the first three-way control unit 23 are controlled to communicate with each other, the cleaning liquid in the cleaning liquid supplement part 11 is injected into the detection part 242 through the pipelines T1-3 and T4 by the first driving member 211, then the first end and the third end of the first three-way control unit 23 are controlled to communicate with each other, and the liquid in the detection part 242 is discharged through the pipeline T4 and the pipeline T1-3 by the waste liquid discharge part 22. The above steps are alternately performed to realize repeated cleaning of the detection part 242, the pipeline T4 and the pipeline T1-3, and by this means, the cleaning effect can be improved.
Further, the waste liquid discharge section 12 is also used to suck the liquid in the detection section 242 into the pipeline T4 and the pipeline T1-3. The cleaning liquid in the pipeline T4 and the pipeline T1 is injected into the detection part 242 through the first driving part 211, and the liquid in the detection part 242 is sucked into the pipeline T4 and the pipeline T1-3 through the waste liquid discharge part 12, so that the cleaning liquid moves back and forth in the pipeline T4 and the pipeline T1-3, the detection part 242, the pipeline T4 and the pipeline T1-3 are cleaned in a reciprocating mode, and the cleaning effect is improved.
Alternatively, the detection portion 242 may be a sheath flow detection system, and in other embodiments, the detection portion 242 may also be other detection systems, such as an impedance detection system.
The reaction cell 241 is configured to receive a sample and a reagent to form a liquid to be detected, the waste liquid discharge portion 22 is further configured to suck the liquid to be detected in the reaction cell 241 into the pipeline T1 between the first three-way control component 23 and the reaction cell 241, and the first driving member 111 is further configured to push the liquid to be detected between the first three-way control component 23 and the three-way connector 281 (i.e., in the pipeline T1-3) into the detection portion 242. The process of injecting the liquid to be detected into the detecting section 242 will be described in detail below.
The first step is as follows: reagents and a sample are added to the reaction cell 241 through the reagent adding assembly 25 and the sample adding assembly 26 of the sample analyzer 20 to form a liquid to be detected. And the liquid to be detected can be uniformly mixed through the first driving member 211, and the specific mixing method refers to the description of the embodiment shown in fig. 1.
The second step: the third control valve 282 is opened to control the first end and the third end of the first three-way control assembly 23 to be communicated, and the liquid to be detected in the reaction tank 241 is sucked into the pipeline T1 through the waste liquid discharge part 22. Wherein the pipeline T1 includes a pipeline T1-1 between the portion to be cleaned 24 and the third control valve 282, a pipeline T1-2 between the third control valve 282 and the three-way joint 281, and a pipeline T1-3 between the three-way joint 281 and the first three-way control assembly 23.
The third step: the third control valve 282 is closed to communicate the first end and the second end of the first three-way control assembly 23, and the hydraulic pressure to be detected in the pipeline T1-3 between the three-way joint 281 and the first three-way control assembly 23 is injected into the detection portion 242 through the first driving member 211. In this way, the liquid to be detected is injected into the detection portion 242 by sharing the components in the cleaning device 201, so that the overall structure of the sample analyzer 10 is simplified, and the hardware cost is saved.
Further, as shown in fig. 4, in the present embodiment, the reagent adding assembly 25 may include a hemolytic agent adding component and a fluorescence adding component, wherein the hemolytic agent adding component includes a hemolytic agent storage portion 252 and a driving member 251, and the fluorescence adding component includes a fluorescence dye solution storage portion 254 and a driving member 253. The hemolytic agent in the hemolytic agent storage portion 252 is added to the reaction cell 241 by the driving member 251, and the fluorescent staining solution in the fluorescent staining solution storage portion 254 is added to the reaction cell 241 by the driving member 253, so that the reagent and the sample form a solution to be detected. It is understood that the reagent adding component 25 may also include other reagent adding components, which may be specifically configured according to the detection items.
In this embodiment, other structures of the sample analyzer 20, such as the cleaning solution replenishing portion 21, the waste liquid discharging portion 22, the first driving member 211, the first three-way control assembly 23, the liquid discharging portion 27, and the sample adding assembly 26, are the same as the corresponding structures of the embodiment shown in fig. 1, and are not described herein again.
For example, as shown in fig. 4, the detection process and the cleaning process of the sample analyzer 20 of the present application are as follows:
the method comprises the following steps: after the counting is started, opening the control valve 271 valve, and emptying the reaction tank 241;
step two: opening the control valve 255, and controlling the driving member 251 to add the hemolytic agent into the reaction tank 241; the sampling needle 262 moves to the reaction cell 241, and the driving member 261 is controlled to add the blood sample to the reaction cell 241;
step three: opening the control valve 256, and controlling the driving member 253 to add the fluorescent reagent into the reaction cell 241; opening the control valve 255, controlling the driving member 251 to add the hemolytic agent into the reaction tank 241 again, and forming a vortex through the liquid to complete uniform mixing;
controlling the first end and the third end of the first three-way control assembly 23 to be communicated, the waste liquid discharge part 12 to pump the uniformly mixed liquid into a pipeline T1-1, a pipeline T1-2 and a pipeline T1-3, then controlling the first end and the second end of the first three-way control assembly 23 to be communicated, controlling the first driving part 211 to push the liquid in the pipeline T1-3 into the detection part 242, and starting counting;
step four: after the counting is finished, the first end and the third end of the first three-way control assembly 23 are controlled to be communicated, and liquid is discharged from the pipeline T1-1, the pipeline T1-2 and the pipeline T1-3; the first end and the second end of the first three-way control assembly 23 are controlled to be communicated, and cleaning liquid is added into the pipeline T1-1, the pipelines T1-2 and T1-3 and the reaction tank 241 through the first driving piece 211;
step five: controlling the first end and the third end of the first three-way control assembly 23 to be communicated, and discharging liquid from the pipeline T1 and the reaction tank 241 through the waste liquid discharge part 22;
step six: and repeating the fourth step and the fifth step, and completing forward and reverse cleaning for multiple times by using the three-way joint 281, the pipeline T1-1, the pipeline T1-2, the pipeline T1-3, the third control valve 282 and other parts. The forward direction represents the direction of the first driving part towards the part to be cleaned along the liquid path, and the reverse direction represents the direction of the part to be cleaned towards the waste liquid collecting tank along the liquid path.
In this embodiment, the cleaning device 201 can clean the reaction cell 241 and the detection portion 242, the cleaning effect is good, the solution to be detected in the reaction cell 241 can be injected into the detection portion 242 through the first driving member 211, the detection process and the cleaning process of the sample can share the first driving member 211, and thus, the hardware cost can be saved.
The above embodiments are merely examples and are not intended to limit the scope of the present disclosure, and all modifications, equivalents, and flow charts using the contents of the specification and drawings of the present disclosure, which are directly or indirectly applied to other related technical fields, are included in the scope of the present disclosure.
Claims (10)
1. A cleaning device for a sample analyzer, the cleaning device comprising:
a cleaning liquid replenishing part, a waste liquid discharging part, a first three-way control component, a first driving part and a part to be cleaned,
wherein a first end of the first three-way control assembly is connected with a first end of the part to be cleaned, a second end of the first three-way control assembly is connected with the cleaning liquid supplementing part, a third end of the first three-way control assembly is connected with the waste liquid discharging part, the cleaning liquid supplementing part is connected with the first driving piece, the first driving piece is used for injecting the cleaning liquid in the cleaning liquid supplementing part into the part to be cleaned,
when the first end of the first three-way control assembly is communicated with the second end of the first three-way control assembly, the first driving piece is also used for injecting cleaning liquid into the part to be cleaned through a pipeline between the first three-way control assembly and the part to be cleaned,
when the first end of the first three-way control component is communicated with the third end of the first three-way control component, the waste liquid discharge part is used for discharging liquid in the part to be cleaned through a pipeline between the part to be cleaned and the first three-way control component so as to realize repeated cleaning of the pipeline between the part to be cleaned and the first three-way control component through alternate communication between the first end of the first three-way control component and the second end of the first three-way control component as well as between the first end of the first three-way control component and the third end of the first three-way control component,
the waste liquid discharge part comprises a second driving piece and a waste liquid collecting pool, the second driving piece is connected with a first end of the waste liquid collecting pool, a second end of the waste liquid collecting pool is connected with a third end of the first three-way control assembly, and the second driving piece is used for sucking liquid in the to-be-cleaned part into the waste liquid collecting pool through a pipeline between the to-be-cleaned part and the first three-way control assembly.
2. The cleaning device according to claim 1, further comprising a second three-way control assembly, wherein a first end of the second three-way control assembly is connected to the first driving member, a second end of the second three-way control assembly is connected to the cleaning solution supplement portion, a third end of the second three-way control assembly is connected to the second end of the first three-way control assembly,
when the first end of the second three-way control assembly is communicated with the second end of the second three-way control assembly, the first driving piece is used for sucking cleaning liquid from the cleaning liquid replenishing part,
when the first end of the second three-way control assembly is communicated with the third end of the second three-way control assembly, the first driving piece is used for driving the cleaning liquid into the part to be cleaned through a pipeline between the first three-way control assembly and the part to be cleaned.
3. The cleaning device of claim 2, wherein the first drive member is a syringe or a metered dose pump.
4. The cleaning device according to claim 2, wherein the to-be-cleaned part is used for receiving a sample and a reagent to form a to-be-detected liquid, the first driving member is further used for sucking the to-be-detected liquid into a pipeline between the to-be-cleaned part and the first three-way control assembly, and the first driving member is further used for driving the to-be-detected liquid in the pipeline between the to-be-cleaned part and the first three-way control assembly to the to-be-cleaned part so as to uniformly mix the to-be-detected liquid.
5. The cleaning device according to claim 2, wherein the portion to be cleaned comprises a reaction tank and a detection portion, the cleaning device further comprises a third control valve and a three-way joint, a first end of the third control valve is connected with the reaction tank, a second end of the third control valve is connected with a first interface of the three-way joint, a second interface of the three-way joint is connected with the detection portion, a third interface of the three-way joint is connected with a first end of the first three-way control assembly,
the first driving piece is also used for injecting cleaning liquid into the detection part through a pipeline between the first three-way control assembly and the detection part and injecting the cleaning liquid into the reaction tank through a pipeline between the first three-way control assembly and the reaction tank;
the waste liquid discharge part is used for discharging liquid in the reaction tank through a pipeline between the reaction tank and the first three-way control assembly, and the waste liquid discharge part is also used for discharging liquid in the detection part through a pipeline between the detection part and the first three-way control assembly so as to realize repeated cleaning of the reaction tank, the detection part, the pipeline between the reaction tank and the first three-way control assembly and the pipeline between the detection part and the first three-way control assembly through alternate communication of the first end of the first three-way control assembly, the three-way joint, the reaction tank and the detection part, the first end of the first three-way control assembly and the third end of the first three-way control assembly.
6. The cleaning device according to claim 5, wherein the reaction cell is configured to receive a sample and a reagent to form a liquid to be detected, the waste liquid discharge portion is further configured to suck the liquid to be detected in the reaction cell into a pipeline between the first three-way control assembly and the reaction cell, and the first driving member is further configured to drive the liquid to be detected in the pipeline between the reaction cell and the first three-way control assembly into the reaction cell to uniformly mix the liquid to be detected;
the first driving piece is further used for pushing the to-be-detected liquid which is positioned between the first three-way control assembly and the three-way joint and is uniformly mixed into the detection portion, so that the detection portion detects a sample of the to-be-detected liquid.
7. The cleaning device of claim 1, further comprising a drain connected to the second end of the portion to be cleaned for draining liquid from the portion to be cleaned.
8. A method for cleaning a sample analyzer, the method being based on the cleaning apparatus according to any one of claims 1 to 7, wherein the method for cleaning comprises:
controlling the first end of the first three-way control assembly to be communicated with the second end of the first three-way control assembly;
cleaning liquid is injected into the part to be cleaned through a pipeline between the first three-way control assembly and the part to be cleaned by the first driving piece and the cleaning liquid supplementing part;
controlling the first end of the first three-way control assembly to be communicated with the third end of the first three-way control assembly;
and the liquid in the part to be cleaned is discharged through the pipeline between the part to be cleaned and the first three-way control component by the waste liquid discharge part, so that the repeated cleaning of the part to be cleaned and the pipeline between the part to be cleaned and the first three-way control component is realized through the alternate communication of the first end of the first three-way control component, the second end of the first three-way control component and the third end of the first three-way control component, wherein,
the waste liquid discharge part comprises a second driving part and a waste liquid collecting pool, the second driving part is connected with the first end of the waste liquid collecting pool, the second end of the waste liquid collecting pool is connected with the third end of the first three-way control component,
the step of discharging the liquid in the part to be cleaned through the waste liquid discharge part through a pipeline between the part to be cleaned and the first three-way control assembly comprises the following steps:
and sucking the liquid in the part to be cleaned into the waste liquid collecting tank through a pipeline between the part to be cleaned and the first three-way control assembly by the second driving piece.
9. The cleaning method according to claim 8, wherein the cleaning apparatus further comprises a second three-way control assembly, a first end of the second three-way control assembly is connected to the first driving member, a second end of the second three-way control assembly is connected to the cleaning solution supplement portion, a third end of the second three-way control assembly is connected to the second end of the first three-way control assembly,
the step of injecting the cleaning liquid into the part to be cleaned through the first driving piece and the cleaning liquid supplementing part via a pipeline between the first three-way control assembly and the part to be cleaned comprises the following steps:
controlling the first end of the second three-way control assembly to be communicated with the second end of the second three-way control assembly;
and sucking up the cleaning liquid from the cleaning liquid replenishing part by the first driving member;
controlling the first end of the second three-way control assembly to be communicated with the third end of the second three-way control assembly;
and the first driving piece is used for injecting the sucked cleaning liquid into the part to be cleaned through a pipeline between the first three-way control assembly and the part to be cleaned.
10. A sample analyzer, the sample analyzer comprising: a cleaning device according to any one of claims 1 to 7.
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Families Citing this family (2)
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|---|---|---|---|---|
| CN116037588A (en) * | 2023-01-17 | 2023-05-02 | 中元汇吉生物技术股份有限公司 | Classification pool cleaning system, method and analyzer |
| CN116106488A (en) * | 2023-04-13 | 2023-05-12 | 深圳市帝迈生物技术有限公司 | Sample analyzer |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4592368A (en) * | 1983-10-11 | 1986-06-03 | Biochem International Inc. | Gas analyzer protection system |
| JPH0448267A (en) * | 1990-06-15 | 1992-02-18 | Hitachi Ltd | Automatic analysis apparatus |
| JP4055232B2 (en) * | 1998-02-03 | 2008-03-05 | 日産自動車株式会社 | Waste liquid recovery device |
| JP4610779B2 (en) * | 2001-04-26 | 2011-01-12 | Ｔｈｋ株式会社 | Microarray manufacturing head and microarray manufacturing apparatus |
| JP2008281480A (en) * | 2007-05-11 | 2008-11-20 | Olympus Corp | Method and device for washing nozzle, and automatic analyzer |
| EP2136210B1 (en) * | 2008-06-18 | 2018-08-15 | Horiba, Ltd. | Body fluid sample analyzer |
| CN101869894B (en) * | 2009-04-24 | 2016-11-09 | 深圳迈瑞生物医疗电子股份有限公司 | Clean device, purging system, cleaning method and particle analyzer |
| JP2014083513A (en) * | 2012-10-25 | 2014-05-12 | Hiroshi Suzuki | Method and system for cleaning pipeline |
| CN104690047B (en) * | 2013-12-10 | 2016-08-24 | 中国科学院大连化学物理研究所 | A kind of liquid chromatograph sample intake passage cleans device |
| CN209156557U (en) * | 2018-08-31 | 2019-07-26 | 深圳市帝迈生物技术有限公司 | A kind of detergent line, cleaning device and sample testing apparatus |
| CN110871202A (en) * | 2018-08-31 | 2020-03-10 | 深圳市帝迈生物技术有限公司 | Sampling needle cleaning method and blood cell analyzer |
| CN210982226U (en) * | 2019-11-06 | 2020-07-10 | 湖南远璟生物技术有限公司 | Magnetic bead separation and cleaning device with mixed structure |
| JP6854870B1 (en) * | 2019-11-27 | 2021-04-07 | 三菱電機株式会社 | Washing and drying method and washing and drying equipment |
| CN112881712A (en) * | 2019-11-30 | 2021-06-01 | 深圳市帝迈生物技术有限公司 | Specific protein detection module, blood detection instrument and detection method |
| CN212410610U (en) * | 2019-11-30 | 2021-01-26 | 深圳市帝迈生物技术有限公司 | Specific protein detection module and blood detection instrument |
| CN113884688A (en) * | 2020-07-03 | 2022-01-04 | 深圳迈瑞生物医疗电子股份有限公司 | Specific protein analyzer, specific protein measuring method, and computer-readable storage medium |
| CN114062661B (en) * | 2020-07-30 | 2022-10-28 | 深圳市帝迈生物技术有限公司 | Sample analyzer, sampling needle cleaning liquid path and cleaning method thereof |
| CN114062226B (en) * | 2020-07-31 | 2024-04-05 | 深圳市帝迈生物技术有限公司 | Liquid path device and sample analyzer |
| WO2022099504A1 (en) * | 2020-11-11 | 2022-05-19 | 深圳市科曼医疗设备有限公司 | Liquid adding method for sampling and drawing reagent, and liquid path system therefor |
| CN114643241B (en) * | 2020-12-18 | 2023-12-01 | 深圳市帝迈生物技术有限公司 | Liquid supply system and liquid supply method |
| CN112798345A (en) * | 2020-12-29 | 2021-05-14 | 深圳市科曼医疗设备有限公司 | Pre-dilution mode sample collection and distribution system, method and blood cell analyzer |
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