CN208334379U - Sample analyser - Google Patents

Sample analyser Download PDF

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Publication number
CN208334379U
CN208334379U CN201721925514.3U CN201721925514U CN208334379U CN 208334379 U CN208334379 U CN 208334379U CN 201721925514 U CN201721925514 U CN 201721925514U CN 208334379 U CN208334379 U CN 208334379U
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machine
storage tank
liquid storage
reagent
reaction unit
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CN201721925514.3U
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Chinese (zh)
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石汇林
燕宇峰
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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Abstract

The application discloses a kind of sample analyser, including sampler, agent delivery device, at least one reaction unit and at least one detection device, sampler acquires a sample to be tested and at least portion of sample to be tested is transferred at least one reaction unit, agent delivery device includes liquid storage tank at least one machine, liquid storage tank draws reagent outside a machine by power source to carry out charging operation to liquid storage tank in machine in each machine in reagent barrel, and the reagent in liquid storage tank in machine is transferred to the reaction unit being connected to liquid storage tank in machine, sample to be tested and reagent hybrid reaction in each reaction unit obtain test solution, detection device detects test solution and generates detection information.By liquid storage tank in machine, reagent barrel draws reagent to the application from the outside, replaces when novel agent bucket that reagent residue amount is low in old reagent barrel, and the time for replacing novel agent bucket is short, and reagent consumption is few when replacing novel agent bucket.

Description

Sample analyser
Technical field
This application involves biological sample analysis field more particularly to a kind of sample analysers.
Background technique
With the development of science and technology, it is quality-high and inexpensive not to be intended merely to product by people, it is also desirable to product in use its The lower use cost the better.For example, sample analyser reagent residue amount in old reagent barrel when replacing novel agent bucket, more renews examination The time of agent bucket, reagent consumption etc. all directly affects the use cost of sample analyser when replacing novel agent bucket.However, existing Reagent residue amount is more in old reagent barrel when replacing novel agent bucket for some sample analysers, and the time for replacing novel agent bucket is long, more Reagent consumption is more when renewing reagent barrel, and use cost is high.
Utility model content
The application embodiment discloses a kind of sample analyser, to solve the above problems.
A kind of sample analyser disclosed in the application embodiment, including sampler, agent delivery device, at least one Reaction unit and at least one detection device, the sampler for acquire a sample to be tested and by the sample to be tested extremely Few portion is transferred at least one described reaction unit, and the agent delivery device includes liquid storage tank at least one machine, each Liquid storage tank draws reagent outside a machine by power source to carry out charging operation to liquid storage tank in the machine in machine in reagent barrel, And the reagent in liquid storage tank in the machine is transferred to the reaction unit being connected to liquid storage tank in the machine, it is each described anti- Sample to be tested and the reagent hybrid reaction in device is answered to obtain test solution, the detection device is detected and generated to the test solution Detection information.
Reagent barrel draws reagent to the sample analyser of the application from the outside, and the time for replacing novel agent bucket is short, more renews examination Reagent consumption is few when agent bucket, and reagent residue amount is low in old reagent barrel.
Detailed description of the invention
In order to illustrate more clearly of the technical solution in the application embodiment, will make below to required in embodiment Attached drawing is briefly described, it should be apparent that, the accompanying drawings in the following description is only some embodiments of the application, right For those of ordinary skill in the art, without creative efforts, it can also be obtained according to these attached drawings His attached drawing.
Fig. 1 is the module diagram of the sample analyser in one embodiment of the application.
Fig. 2 is the fluid path schematic diagram of the agent delivery device and reaction unit in the application first embodiment.
Fig. 3 is the fluid path schematic diagram of the agent delivery device and reaction unit in the application second embodiment.
Fig. 4 is the fluid path schematic diagram of the agent delivery device and reaction unit in the application third embodiment.
Fig. 5 is the fluid path schematic diagram of the agent delivery device and reaction unit in the 4th embodiment of the application.
Fig. 6 is the flow diagram of the agent delivery method of the sample analyser in the application first embodiment.
Fig. 7 is the flow diagram of the agent delivery method of the sample analyser in the application second embodiment.
Specific embodiment
Below in conjunction with the attached drawing in the application embodiment, the technical solution in the application embodiment is carried out clear Chu is fully described by, it is clear that described embodiment is only a part of embodiment of the application, rather than whole implementation Mode.Based on the embodiment in the application, those of ordinary skill in the art are obtained without making creative work The every other embodiment obtained, shall fall in the protection scope of this application.
Referring to Fig. 1, Fig. 1 is the module diagram of the sample analyser 100 in one embodiment of the application.The sample Analyzer 100 is used to carry out medical analysis to sample to be tested and generates corresponding detection information.It is described to be measured in present embodiment Sample is blood sample.It is understood that in other embodiments, the sample to be tested can also be body fluid sample, serum sample, Plasma sample, urine specimen or other suitable biological sample, herein with no restrictions.Specifically, the sample analyser 100 wraps Include sampler 10, agent delivery device 30, at least one reaction unit 50 and at least one detection device 70.The sampling dress Set 10 for acquire a sample to be tested (not shown) and by at least portion of the sample to be tested be transferred to it is described at least one instead Answer device 50.It is understood that in the present embodiment, the sample to be tested can be divided into more parts by the sampler 100, and will be every Part sample to be tested is transferred to the corresponding reaction unit 50.In other embodiments, every part of sample to be tested can pass through The mode of needle tubing injection is transferred to the corresponding reaction unit 50.It is the first embodiment party of the application please also refer to Fig. 2, Fig. 2 The fluid path schematic diagram of agent delivery device 30 and reaction unit 50 in formula.The agent delivery device 30 includes at least one machine Interior liquid storage tank 31 and power source 32.The power source 32 is connected to liquid storage tank 31 in each machine respectively.In present embodiment, The power source 32 is high-pressure pump, can generate negative pressure.In each machine liquid storage tank 31 by the power source 32 from Reagent is drawn in the outer reagent barrel 33 of one machine to carry out charging operation to the reagent of liquid storage tank 31 in the machine.Wherein, the reagent Including but not limited to: hemoglobinometry hemolytic agent, leukocyte analysis hemolytic agent, erythroblast analysis hemolytic agent and Granulophilocyte analysis dilution etc..Any one reagent can be filled as needed in the reagent barrel 33.Described " charging " Refer to and fills liquid storage tank 31 in the machine with reagent.During the progress of liquid storage tank 31 reagent charges in the machine, the machine The air of interior liquid storage tank 31 is discharged along the flow path in the machine between liquid storage tank 31 and the power source 32, therefore is not required to additional Special exhaust steep step.
Specifically, the capacity of liquid storage tank 31 is smaller in each machine, is not more than 100 milliliters, liquid storage tank 31 in the machine Low capacity make liquid storage tank 31 in the machine charge that speed is fast, in the replacement one new examination for filling reagent full of reagent After agent bucket 33, supplementing the time that the liquid measure is consumed only is needed several seconds, it is fast that replacement reagent speed may be implemented, it is possible to reduce the sample The stand-by time of analyzer 100 improves working efficiency, more efficient service is provided for client.
Specifically, the sample analyser 100 includes board (not shown), and the board has an accommodating space, and (figure is not Show), liquid storage tank 31 is arranged in the accommodating space in the machine.
It preferably, can be by the reagent barrel in order to reduce or be discharged the bubble in agent delivery device pipeline as far as possible 33 are placed on the ground outside the board, and the level height of the position of liquid storage tank 31 is higher than the reagent barrel 33 in the machine And it is lower than the reaction unit 50.It in other embodiments, can also be by the receiving in order to facilitate the arrangement of machine inner assembly The top of the board is arranged in space.
Reagent in each machine in liquid storage tank 31 is transferred to the reaction unit being connected to liquid storage tank 31 in the machine 50.Sample to be tested and reagent hybrid reaction in each reaction unit 50 obtain test solution.The detection device 70 is to described Test solution is detected and generates detection information.
Specifically, liquid storage tank 31 and at least one described reaction unit 50 one-to-one correspondence are connected to and set at least one described machine It sets.Liquid storage tank 31 is that the corresponding reaction unit 50 provides reagent in each machine.
Specifically, at least one described reaction unit 50 and at least one described detection device 70 are arranged in a one-to-one correspondence.Often A reaction unit 50 is that the corresponding detection device 70 provides test solution, so that the detection device 70 carries out test solution detection And generate corresponding detection information.
Specifically, liquid storage tank 31 is connected with the corresponding reagent barrel 33 in each machine, moreover, each machine Interior liquid storage tank 31 is without valve but is directly connected with the corresponding reagent barrel 33.
Specifically, the reagent of liquid storage tank 31 is transferred to and described the reacting of the connection of liquid storage tank 31 in the machine in each machine During device 50, confined space is formed between liquid storage tank 31 and the corresponding reagent barrel 33 in the machine.
Wherein, the confined space is the confined space of normal pressure." normal pressure " refers in the machine in liquid storage tank 31 Pressure is held essentially constant, and only when supplying reagent to the corresponding reaction unit 50, dynamic generates of short duration negative pressure, and The negative pressure adds in the machine after the reagent in the reagent barrel 33 just to disappear after liquid storage tank 31.
Specifically, liquid storage tank 31 is supplied to the reaction unit 50 being connected to liquid storage tank 31 in the machine every time in the machine After answering reagent, the negative pressure formed between liquid storage tank 31 and the reaction unit 50 in the machine promote in the machine liquid storage tank 31 from The reagent barrel 33 draws reagent to replenish in the machine in liquid storage tank 31.
Specifically, the agent delivery device 30 further includes at least one constant displacement pump 312, and each setting of constant displacement pump 312 exists In the corresponding machine between liquid storage tank 31 and the reaction unit 50 being connect with liquid storage tank 31 in the machine, the constant displacement pump 312 out of described machine liquid storage tank 31 draw quantitative reagent and be transferred to and described reacted with what liquid storage tank 31 in the machine was connected Device 50.Further specifically, pass through three in the machine between liquid storage tank 31, the constant displacement pump 312 and the reaction unit 50 Port valve 313 connects.The constant displacement pump 312 is connect by triple valve 314 with negative pressure power source 3151 and positive pressure power source 3152.Institute Stating negative pressure power source 3151 promotes the constant displacement pump 312 liquid storage tank 31 out of described machine to draw reagent.The positive pressure power source 3152 promote the constant displacement pump 312 to deliver reagents into the reaction unit 50.Preferably, the level of the position of constant displacement pump is high It is low, it is higher than liquid storage tank 31 in the machine and is lower than the reaction unit 20.
Specifically, the constant displacement pump 312 is when liquid storage tank 31 draws the quantitative reagent out of described machine, storage in the machine The confined space that liquid pool 31 is connected and is formed with the reagent barrel 33, in the machine liquid storage tank 31 every time to stored up in the machine After the reaction unit 50 that liquid pool 31 is connected to supplies the quantitative reagent, liquid storage tank 31 and the reagent barrel 33 in the machine Between the negative pressure that is formed promote in the machine liquid storage tank 31 to draw the quantitative reagent from the reagent barrel 33 to supplement In the machine in liquid storage tank 31.
To which liquid storage tank 31 is added into the reaction unit 50 connecting with liquid storage tank 31 in the machine in the machine When after reagent, certain negative pressure is formed in the machine in liquid storage tank 31, the negative pressure promotes automatic from 33 inside of reagent barrel The reagent of consumption is supplemented, the sample analyser 100 carries out being not necessarily to additionally recharge storage in the machine during sample analysis Liquid pool 31 can save the system air consumption in measurement process.
Specifically, the agent delivery device 30 further includes controller 310 and at least one first control valve 34, Mei Gesuo Liquid storage tank 31 in machine is stated to connect by corresponding first control valve 34 with the power source 32.
The controller 310 controls at least one described first control valve 34 and opens with to right with first control valve 34 Liquid storage tank 31 charges reagent in the machine answered.Specifically, first control valve 34 open when, the power source 32 with it is described It is connected between liquid storage tank 31 in machine.Therefore, it is possible to by the power source 32 to described in being connect with first control valve 34 Liquid storage tank 31 charges reagent in machine.
The controller 310 controls at least one described first control valve 34 and closes to stop the liquid storage tank 31 into the machine Charge reagent.Specifically, when first control valve 34 is closed, do not connect between liquid storage tank 31 in the power source 32 and the machine It is logical.Thus, it is not possible to liquid storage tank 31 in the machine connecting with first control valve 34 is charged by the power source 32 Reagent.
It is understood that in present embodiment, in the quantity of at least one first control valve 34 and at least one described machine The quantity of liquid storage tank 31 is identical, at least one described first control valve 34 is corresponded with liquid storage tank 31 at least one described machine Connection setting, at least one described first control valve 34 are connect with the power source 32 respectively.To at least one described machine Liquid storage tank 31 can be respectively adopted the different pressure progress reagents that charges and charge operation, also, liquid storage tank 31 can in each machine Complete independently charges operation, is not influenced by liquid storage tank 31 in machine described in other.
Specifically, the agent delivery device 30 further includes at least one level sensor 35.It is described in present embodiment Level sensor 35 is float.The float is mobile with liquid level, and can be with real-time detection liquid level to obtain liquid level information.It can Understand, in other embodiments, the level sensor 35 includes at least two pieces of level plates, the corresponding need of each level plate The liquid level to be monitored.Level plate is connect by connecting rod with sensor, and whether liquid level reaches target liquid level, can generate two kinds of electricity Signal generates liquid level information.
At least one described level sensor 35 is correspondingly arranged with liquid storage tank 31 at least one described machine.Wherein, each At least one described level sensor 35 is set in liquid storage tank 31 in the machine, and the controller 310 is in the level sensor 35 when sensing the first liquid level, control the closing of first control valve 34 corresponding with the level sensor 35 with stop to Liquid storage tank 31 charges reagent in the corresponding machine of the level sensor 35, and the controller 310 is in the level sensor 35 when sensing the second liquid level, controls the agent delivery device 30 and stops providing reagent to the reaction unit 50.Wherein, originally In embodiment, first liquid level is high liquid level, and second liquid level is low liquid level.
Specifically, the controller 310 controls the agent delivery device 30 and stops providing examination to the reaction unit 50 After agent, generate without reagent fault message.When user's replacement fills the novel agent bucket 33 of reagent and in the sample analyser 100 After point disappears failure in user interface, the controller 310 controls first control valve corresponding with the level sensor 35 34 open, to transfer liquid storage tank 31 in reagent to the machine out of novel agent bucket 33 under the driving of the power source 32.It is described Controller 310 controls corresponding with the level sensor 35 described when the level sensor 35 senses the first liquid level First control valve 34 is closed to stop charging.
Specifically, the difference in height in the machine between the first liquid level and the second liquid level of liquid storage tank 31 is smaller, thus due to It is completely to arrive the level sensor 35 to detect liquid storage tank in the machine that the level sensor 35, which detects liquid storage tank 31 in the machine, 31 be empty process, and the liquid level decline of liquid storage tank 31 is smaller in the machine, after one novel agent bucket 33 full of reagent of replacement, Supplementing the time that the liquid measure is consumed only needs several seconds, and it is fast to may be implemented replacement reagent speed, can be further reduced the sample point The stand-by time of analyzer 100 improves working efficiency, more efficient service is provided for client.
Specifically, the controller 310 is issued when the level sensor 35 senses third liquid level without reagent failure Information, while the reagent in the machine in liquid storage tank 31 is persistently transferred to the reaction connecting with liquid storage tank 31 in the machine Device 50.When the novel agent bucket 33 of reagent is filled in user's replacement and puts the event that disappears in the user interface of the sample analyser 100 After barrier, the controller 310 control first control valve 34 be connected in the power source 32 and the machine liquid storage tank 31 with Liquid storage tank 31 in reagent to the machine, and institute during charging are transferred under the driving of the power source 32 out of novel agent bucket 33 It states the reagent in machine in liquid storage tank 31 and is persistently transferred to the reaction unit 50 connecting with liquid storage tank 31 in the machine.Its In, the third liquid level is an early warning liquid level, between first liquid level and second liquid level.To institute's sample Analyzer 100 is generated without reagent fault message, when the level sensor 35 senses third liquid level to provide user's replacement Novel agent bucket 33 simultaneously executes and charges operation again, and generates without reagent fault message to during charging operation again, institute The reagent for stating liquid storage tank 31 in machine is constantly provided the reaction unit 50 connecting with liquid storage tank 31 in the machine, realizes Replacement reagent is not shut down, saves the time for user, there is better user experience.
Specifically, the power source 32 be charge again the negative pressure provided absolute value be less than the constant displacement pump 312 will examination Agent liquid storage tank 31 out of described machine is transferred to the pressure absolute value of the reaction unit 50.It is understood that in one embodiment, it can It is to charge to provide negative pressure again by lower negative pressure air pump set in addition.It in another embodiment, can be by set in addition Reagent in the reagent barrel 33 is transplanted in the machine in liquid storage tank 31 by constant displacement pump or syringe repeatedly.
Specifically, the controller 310 controls first control valve 34 and is connected to storage in the power source 32 and the machine After the execution of liquid pool 31 charges preset time period, when the level sensor 35 is still without most the first liquid level is sensed, described in control Agent delivery device 30 stops providing reagent to the reaction unit 50.
To which using 35 detection reagent of the level sensor in liquid storage tank 31 in the machine, whether there is or not when liquid level declines When to the level sensor 35 and generating trigger signal, generate without reagent fault message, at this point, the examination in the reagent barrel 33 Agent has been drawn into the greatest extent in the machine in liquid storage tank 31, and the reagent residue amount in the reagent barrel 33 is low.Replacement is full of After the novel agent bucket 33 of reagent, using the power source 32, the reagent in the reagent barrel 33 is charged into liquid storage in the machine Pond 31 then replaces reagent success, during this, the sample point when the level sensor 35 floats and generates trigger signal Analyzer 100 does not consume reagent, and replacement reagent is in the process without reagent waste.
It is the agent delivery device 30a and reaction unit 50 in the application second embodiment please also refer to Fig. 3, Fig. 3 Fluid path schematic diagram.The agent delivery device 30a is similar to the agent delivery device 30, and difference place is, the examination The power source 32a of agent feeding mechanism 30a is small air pump, described stingy unlike the high-pressure pump in first embodiment Pump it is at low cost, can also be used to generate charge reagent needs negative pressure, but the high-pressure pump can not only generate charge reagent need The negative pressure wanted, moreover it is possible to generate positive pressure, be used as other purposes.
It is the agent delivery device 30b and reaction unit 50 in the application third embodiment please also refer to Fig. 4, Fig. 4 Fluid path schematic diagram.The agent delivery device 30b is similar to the agent delivery device 30, and difference place is, the examination Agent feeding mechanism 30b further includes waste liquid pool 36, third control valve 38 and waste liquid barrel 39.The waste liquid pool 36 collects the reaction dress The test solution of 50 and the detection device 70 is set, the waste liquid barrel 39 is connect with the waste liquid pool 36, and the setting of waste liquid pool 36 exists In at least one described machine between liquid storage tank 31 and the power source 32, the third control valve 38 is arranged in the waste liquid pool 36 Between the power source 32.The power source 32 is high-pressure pump, can provide positive pressure, can also provide negative pressure.It is described When third control valve 38 is opened, the power source 32 provides positive pressure to the waste liquid pool 36 to empty the waste liquid of waste liquid pool 36 to institute It states in waste liquid barrel 39, the power source 32 provides negative pressure to the waste liquid pool 36 to collect waste liquid to the waste liquid pool 36.It is described Waste liquid pool 36 is also connect by the first control valve 34 with liquid storage tank 31 in the machine, when liquid storage tank 31 needs to charge in machine, is beaten The first control valve 34 is opened, waste liquid pool 36 is that liquid storage tank 31 provides negative pressure in machine, so that described in the reagent entrance of the reagent barrel 33 Liquid storage tank 31 in machine.
It is understood that in other embodiments, the third control valve 38 can be omitted, the power source 32 directly with it is described Waste liquid pool 36 connects.
It is understood that when user's replacement fills the novel agent bucket 33 of reagent and in the user interface of the sample analyser 100 Upper point disappears after failure, and the negative pressure absolute value for reconciling the waste liquid pool 36 is less than the constant displacement pump 312 31 pond of liquid storage out of described machine The pressure for drawing reagent does not influence the constant displacement pump 312 and works, and the reagent of the reagent barrel 33 is allowed to enter liquid storage tank in the machine 31, when the level sensor 35 senses first liquid level, charge completion.
The power source 32 for charging liquid storage tank 31 in the machine is received using the sample analyser 100 for other channel waste liquids The waste liquid pool 36 of collection, its advantage is that when the level sensor 35 has exception accurately not detect liquid level, liquid storage in the machine Reagent inside pond 31 may flow backward into gas circuit, and after the waste liquid pool 36, reagent can be in the waste liquid pool 36 The gas source cached without entering instrument damages the sample analyser.
After replacement is full of the novel agent bucket 33 of reagent, using the power source 32 in the waste liquid pool 36, by the examination Reagent in agent bucket 33 charges liquid storage tank 31 in the machine, after the level sensor 35 floats and generates trigger signal then Reagent success is replaced, during this, the sample analyser 100 does not consume reagent, without reagent waste during replacement reagent.
It is the agent delivery device 30c and reaction unit 50 in the 4th embodiment of the application please also refer to Fig. 5, Fig. 5 Fluid path schematic diagram.The agent delivery device 30c is similar to the agent delivery device 30b, and difference place is, the examination Agent feeding mechanism further includes at least one the first control valve 34 and at least one second control valve 37, at least one described first control Valve 34 processed is identical as first embodiment, and details are not described herein again, the setting of described at least one second control valve 37 it is described extremely On the flow path connected between liquid storage tank 31 and at least one described reagent barrel 33 in a few machine, at least one described second control The execution of liquid storage tank 31 in the machine of valve 37 charges reagent and makes the machine during supplying reagent to the reaction unit 50 Interior liquid storage tank 31 is connected to the reagent barrel 33, the emptying of liquid storage tank 31 examination in the machine of at least one described second control valve 37 Atmosphere is connected to when agent is to be overhauled.
Specifically, it is corresponded between liquid storage tank 31 at least one described second control valve 37 and at least one described machine It connects, connects one to one between liquid storage tank 31 at least one described second control valve 37 and at least one described machine.
Increasing by second control valve 37 in the reagent barrel 33 and the machine between liquid storage tank 31, is being advantageous in that, is The needs of maintenance etc., without by the bottle cap component (figure of the reagent barrel 33 when need to empty the reagent of liquid storage tank 31 in the machine Do not show) put forward from the reagent barrel 33 to connect atmosphere, but second control valve 37 is switched on atmosphere, Operation convenient to overhaul.
Fig. 6 is the flow diagram of the agent delivery method of the sample analyser 100 in the application first embodiment.Institute Agent delivery method is stated applied in sample analyser 100 above-mentioned, execution sequence is not limited to sequence shown in fig. 6.It is described Method comprising steps of
Step 610: liquid storage tank 31 in a machine with reagent is provided, in the machine liquid storage tank 31 and with liquid storage in the machine Confined space is formed between the outer reagent barrel 33 of the connected machine in pond 31.Specifically, the confined space is the confined space of normal pressure.
Step 620: providing a reagent transfer device, reagent transfer device liquid storage tank 31 out of described machine moves reagent While being sent to reaction unit 50 that liquid storage tank 31 is connected in the machine, negative pressure is formed in the confined space.Wherein, the examination Agent transfer device can be constant displacement pump 312, syringe etc..
Step 630: the negative pressure promotes in the machine liquid storage tank 31 to draw reagent from the reagent barrel 33 to replenish It states in machine in liquid storage tank 31.
Specifically, the reagent transfer device is transplanted on the amount of the reagent of liquid storage tank 31 in the machine every time and supplements every time The amount of the reagent of liquid storage tank 31 is equal in the machine.
Selectively, the agent delivery method further comprises the steps of:
Step 640: obtaining the liquid level information of the reagent of liquid storage tank 31 in the machine.Specifically, the controller 310 passes through The level sensor 35 obtains the liquid level information of the reagent of liquid storage tank 31 in the machine.
Step 650: when judging that the liquid level is in the second liquid level, controlling the reagent transfer device stopping movement.Specifically Ground when the controller 310 judges that the liquid level is in second liquid level, controls the reagent transfer device stopping movement. Wherein, low liquid level when second liquid level.
Selectively, the agent delivery method further comprises the steps of:
Step 660: the reagent transfer device stopping movement being generated without reagent fault message.Specifically, the controller The 310 controls reagent transfer device stopping movement, generates without reagent fault message, and control the sample analyser 100 The no reagent fault message is shown in user interface.
Step 670: after obtaining Failure elimination information, liquid storage tank 31 is under the driving of the power source 32 from one in the machine Liquid storage tank 31 in transfer reagent to the machine in the outer reagent barrel 33 of machine.
Specifically, after point of the response of controller 310 user in the user interface disappears failed operation, failure is obtained Information is eliminated, and controls liquid storage tank 31 in the machine and transfers reagent out of described reagent barrel 33 under the driving of the power source 32 Liquid storage tank 31 in the machine.
Step 680: obtaining the liquid level information of the reagent of liquid storage tank 31 in the machine, judge that the liquid level is in the first liquid level When, stop reagent transfer.Specifically, the controller 310 obtains liquid storage tank 31 in the machine by the level sensor 35 Reagent liquid level information when, judge that the liquid level is in the first liquid level, that is, when high liquid level, control first control valve 34 closings charge reagent to stop the liquid storage tank 31 into the machine.
In the present embodiment, liquid storage tank 31 is to provide reagent in the reaction unit 50 connected to it in the machine Afterwards, certain negative pressure is formed in the machine in liquid storage tank 31, the negative pressure promotes to be automatically replenished inside the reagent barrel 33 and disappear The reagent of consumption, the sample analyser 100 carry out being not necessarily to additionally recharge liquid storage tank 31 in the machine during sample analysis, The system air consumption in measurement process can be saved.In addition, agent delivery device can stop in the first liquid level to the machine Interior liquid storage tank 31 charges reagent, and the reagent transfer device stopping movement being controlled in the second liquid level, can on the one hand avoid In the machine on the other hand liquid storage tank 31 avoids hypovolia that bubble is caused to enter the machine due to hypervolia reverse irrigation air inlet path Fluid path between interior liquid storage tank 31 and the reaction unit 50.The sample analyser 100 of the present embodiment mode has and is arranged in instrument Liquid storage tank 31 in the machine of small volume inside device charges liquid storage in machine first by the reagent of reagent barrel 33 outside machine, such as hemolytic agent Then pond 31 makes liquid storage tank 31 and the outer reagent barrel 33 of machine in machine form pressure balanced confined space, utilizes liquid storage tank in machine The of short duration negative pressure that 31 transfer reagents are generated to reaction unit 50 makes the reagent of reagent barrel 33 outside machine that liquid storage in machine be replenished in time Pond 31 can make full use of reagent, and shorten the time that instrument caused by reagent is replaced stops working, and improve test speed.
Fig. 7 is the flow diagram of the agent delivery method of the sample analyser 100 in the application second embodiment.Institute Agent delivery method is stated applied in sample analyser 100 above-mentioned, execution sequence is not limited to sequence shown in Fig. 7.It is described Method comprising steps of
Step 710: liquid storage tank 31 in a machine with reagent is provided, in the machine liquid storage tank 31 and with liquid storage in the machine Confined space is formed between the outer reagent barrel 33 of the connected machine in pond 31.Specifically, the confined space is the confined space of normal pressure.
Step 720: providing a reagent transfer device, reagent transfer device liquid storage tank 31 out of described machine moves reagent While being sent to reaction unit 50 that liquid storage tank 31 is connected in the machine, negative pressure is formed in the confined space.
Step 730: the negative pressure promotes in the machine liquid storage tank 31 to draw reagent from the reagent barrel 33 to replenish It states in machine in liquid storage tank 31.
Specifically, the reagent transfer device is transplanted on the amount of the reagent of liquid storage tank 31 in the machine every time and supplements every time The amount of the reagent of liquid storage tank 31 is equal in the machine.
Selectively, the agent delivery method further comprises the steps of:
Step 740: obtaining the liquid level information of the reagent of liquid storage tank 31 in the machine.Specifically, the controller 310 passes through The level sensor 35 obtains the liquid level information of the reagent of liquid storage tank 31 in the machine.
Step 750: when judging that the liquid level is in third liquid level, generating without reagent fault message, while the reagent moves Device is sent still to need liquid storage tank in slave to transfer reagent to the reaction unit connecting with liquid storage tank in the machine according to detection 50.Specifically, the controller 310 is believed by the liquid level that the level sensor 35 obtains the reagent of liquid storage tank 31 in the machine Breath when judging that the liquid level is in third liquid level i.e. early warning liquid level, is generated without reagent fault message, while the reagent moves Device is sent still to need to transfer reagent to the reaction unit 50 connecting with liquid storage tank 31 in the machine according to detection.
Step 760: after obtaining Failure elimination information, liquid storage tank 31 is under the driving of the power source 32 from one in the machine Liquid storage tank 31 is charged in transfer reagent to the machine in the outer reagent barrel 33 of machine, and during charging, liquid storage in the machine Reagent in pond 31 still needs to be transferred to the reaction unit 50 connecting with liquid storage tank 31 in the machine according to detection.Specifically Ground, point of the response of controller 310 user in the user interface disappear after failed operation, obtain Failure elimination information, and Liquid storage tank 31 in the machine is controlled to transfer in reagent to the machine out of described reagent barrel 33 under the driving of the power source 32 Liquid storage tank 31 is charged, and during charging, and the reagent in the machine in liquid storage tank 31 still needs to be transferred to according to detection The reaction unit 50 being connect with liquid storage tank 31 in the machine.
Step 770: sensing that the liquid level in the machine in liquid storage tank 31 is in the first liquid level in the level sensor 35 When, stop reagent transfer.Specifically, the controller 310 senses liquid storage tank 31 in the machine in the level sensor 35 When interior liquid level is in the first liquid level, i.e. high liquid level, stop reagent transfer.
In the present embodiment, institute's sample analyser 100 is generated when the level sensor 35 senses third liquid level Without reagent fault message, operation is charged again to provide user's replacement novel agent bucket 33 and execute, and generate without reagent failure Information is to during charging operation again, and the reagent of liquid storage tank 31 is constantly provided and liquid storage tank in the machine in the machine The reaction unit 50 of 31 connections, realizes and does not shut down replacement reagent, saves the time for user, has better user's body It tests.
It should be noted that for simple description, therefore, it is stated as a systems for each embodiment of the method above-mentioned The combination of actions of column, but those skilled in the art should understand that, the application is not limited by the described action sequence, because For according to the application, certain some step be can be performed in other orders or simultaneously.Secondly, those skilled in the art also should Know, the embodiments described in the specification are all preferred embodiments, related actions and modules not necessarily this Shen It please be necessary.
In the above-described embodiments, it all emphasizes particularly on different fields to the description of each embodiment, is not described in some embodiment Part, reference can be made to the related descriptions of other embodiments.
Step in the embodiment of the present application method can be sequentially adjusted, merged and deleted according to actual needs.
The above is the preferred embodiment of the application, it is noted that for those skilled in the art For, under the premise of not departing from the application principle, several improvements and modifications can also be made, these improvements and modifications are also considered as The protection scope of the application.

Claims (17)

1. a kind of sample analyser, including sampler, agent delivery device, at least one reaction unit and at least one detection Device, which is characterized in that the sampler is used to acquire a sample to be tested and transfers at least a of the sample to be tested To at least one described reaction unit, the agent delivery device includes liquid storage tank at least one machine, liquid storage tank in each machine Draw reagent in reagent barrel outside a machine by power source to carry out charging operation to liquid storage tank in the machine, and by the machine Reagent in interior liquid storage tank is transferred to the reaction unit being connected to liquid storage tank in the machine, in each reaction unit Sample to be tested and reagent hybrid reaction obtain test solution, and the detection device detects the test solution and generates detection information.
2. sample analyser as described in claim 1, which is characterized in that at least one described machine liquid storage tank and it is described at least One reaction unit corresponds connection setting, and liquid storage tank provides reagent for the corresponding reaction unit in each machine.
3. sample analyser as described in claim 1, which is characterized in that the reagent of liquid storage tank is transferred in each machine During the reaction unit being connected to liquid storage tank in the machine, formed between liquid storage tank and the reagent barrel in the machine Confined space.
4. sample analyser as claimed in claim 3, which is characterized in that in the machine liquid storage tank every time to stored up in the machine After the reaction unit supply reagent of liquid pool connection, the negative pressure formed between liquid storage tank and the reaction unit in the machine promotees Liquid storage tank is set in the machine to draw reagent from the reagent barrel to replenish in the machine in liquid storage tank.
5. such as the described in any item sample analysers of Claims 1-4, which is characterized in that the agent delivery device further includes Liquid storage tank and the institute connecting with liquid storage tank in the machine in the corresponding machine is arranged at least one constant displacement pump, each constant displacement pump It states between reaction unit, constant displacement pump liquid storage tank out of described machine is drawn quantitative reagent and is transferred to and liquid storage in the machine The reaction unit that pond is connected.
6. sample analyser as claimed in claim 5, which is characterized in that it is fixed that constant displacement pump liquid storage tank out of described machine is drawn When the reagent of amount, liquid storage tank is connected with the reagent barrel in the machine, in the machine liquid storage tank every time to the machine After the reaction unit of interior liquid storage tank connection supplies the quantitative reagent, in the machine between liquid storage tank and the reagent barrel The negative pressure of formation promotes in the machine liquid storage tank to draw the quantitative reagent from the reagent barrel to replenish the machine In interior liquid storage tank.
7. sample analyser as described in claim 1, which is characterized in that in the machine liquid storage tank without valve directly with it is described Reagent barrel is connected.
8. sample analyser as described in claim 1, which is characterized in that the agent delivery device further includes controller and extremely Lacking first control valve, liquid storage tank is connect by corresponding first control valve with the power source in each machine, The power source provides negative pressure, and the controller controls at least one described first control valve and opens to control to described first Liquid storage tank charges reagent in the corresponding machine of valve, and the controller controls at least one described first control valve and closes to stop Into the machine, liquid storage tank charges reagent.
9. sample analyser as claimed in claim 8, which is characterized in that the quantity of at least one first control valve and institute The quantity for stating liquid storage tank at least one machine is identical, liquid storage tank at least one described first control valve and at least one described machine It connects one to one, at least one described first control valve is connect with the power source respectively.
10. such as the described in any item sample analysers of claim 8 to 9, which is characterized in that the agent delivery device further includes Liquid storage tank and at least one is arranged at least one described machine at least one second control valve, at least one described second control valve On the flow path connected between a reagent barrel, the liquid storage tank execution in the machine of at least one described second control valve charges examination Agent with supply reagent to the reaction unit during be connected to liquid storage tank with the reagent barrel, described at least one A second control valve is connected to atmosphere when liquid storage tank empties in the machine.
11. sample analyser as claimed in claim 10, which is characterized in that at least one described second control valve and it is described extremely It connects one to one between liquid storage tank in a few machine, liquid storage at least one described second control valve and at least one described machine It connects one to one between pond.
12. sample analyser as claimed in claim 8, which is characterized in that the agent delivery device further includes waste liquid pool, institute State the test solution that waste liquid pool collects the reaction unit and the detection device, the waste liquid pool setting it is described at least one first Between control valve and the power source, the power source empties the waste liquid of waste liquid pool to waste liquid pool offer positive pressure, described Power source provides negative pressure to the waste liquid pool to collect waste liquid to the waste liquid pool;The waste liquid pool connects liquid storage in the machine Pond provides negative pressure for liquid storage tank in the machine, so that the reagent of the reagent barrel enters liquid storage tank in the machine.
13. sample analyser as described in claim 1, which is characterized in that the capacity of liquid storage tank is no more than 100 in the machine Milliliter.
14. sample analyser as claimed in claim 8, which is characterized in that liquid storage tank further includes liquid at least one described machine Position inductor, the controller control corresponding with the level sensor when the level sensor senses the first liquid level First control valve close and to stop the liquid storage tank into the machine corresponding with the level sensor charge reagent, it is described Controller controls the agent delivery device and stops to the reaction unit when the level sensor senses the second liquid level Reagent is provided.
15. sample analyser as claimed in claim 14, which is characterized in that the controller controls the agent delivery device Stop after providing reagent to the reaction unit, the controller control corresponding with the level sensor described first controls Valve is opened to execute the movement charged again, and the controller is in the first liquid level that the level sensor senses, control First control valve corresponding with the level sensor is closed to stop charging.
16. sample analyser as claimed in claim 14, which is characterized in that the controller incudes in the level sensor When to third liquid level, issue without reagent fault message, at the same the reagent in the machine in liquid storage tank be persistently transferred to it is described The reaction unit that liquid storage tank connects in machine.
17. sample analyser as described in claim 1, which is characterized in that the sample analyser includes board, the board With an accommodating space, liquid storage tank is arranged in the accommodating space in the machine;The accommodating space is arranged in the board Top.
CN201721925514.3U 2017-12-30 2017-12-30 Sample analyser Active CN208334379U (en)

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CN201721925514.3U CN208334379U (en) 2017-12-30 2017-12-30 Sample analyser

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Application Number Priority Date Filing Date Title
CN201721925514.3U CN208334379U (en) 2017-12-30 2017-12-30 Sample analyser

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CN208334379U true CN208334379U (en) 2019-01-04

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