CN111721956A - Liquid path system of full-automatic biochemical analyzer - Google Patents
Liquid path system of full-automatic biochemical analyzer Download PDFInfo
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- CN111721956A CN111721956A CN201910212314.0A CN201910212314A CN111721956A CN 111721956 A CN111721956 A CN 111721956A CN 201910212314 A CN201910212314 A CN 201910212314A CN 111721956 A CN111721956 A CN 111721956A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1004—Cleaning sample transfer devices
Abstract
The invention discloses a liquid path system of a full-automatic biochemical analyzer, wherein a water adding module comprises a water storage unit and a pressurizing unit connected with the water storage unit, the sample adding cleaning module comprises a sample adding needle cleaning unit, a reagent needle cleaning unit and a stirring rod cleaning unit, the reaction cup cleaning module comprises a reaction cup cleaning liquid path unit and a double-end negative pressure pump, the reaction cup cleaning liquid path unit and the double-end negative pressure pump are both communicated with the inside of a reaction cup, the waste liquid collecting module comprises a waste liquid collecting unit and a reagent refrigerating chamber condensation pipeline communicated with the waste liquid collecting unit, water outlet ends of the sample adding needle cleaning unit, the reagent needle cleaning unit and the stirring rod cleaning unit are all communicated with the reagent refrigerating chamber condensation pipeline, and a water outlet end of the double-end negative pressure pump is communicated with the waste liquid collecting. The invention fully utilizes the performance of the device and the common physical principle to realize the function requirement of the machine, simplifies the structure and control, thereby improving the system stability and greatly reducing the cost.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a liquid path system of a full-automatic biochemical analyzer.
Background
The full-automatic biochemical analyzer is one of the most frequently used important analytical instruments in clinical examination, has important significance in aspects of auxiliary diagnosis, curative effect detection, health examination, drug abuse and the like, has high measurement speed, high accuracy, small reagent consumption and simple and convenient operation, adopts the photoelectric colorimetric principle, automatically operates the steps of sampling, reagent adding, uniformly mixing, heat preservation reaction, detection, result calculation, display, cleaning and the like in the analysis process, measures a certain specific chemical component in body fluid, is an indispensable instrument for medical treatment, disease control units and biological research at all levels, and is also one of the fields of the current medical instrument industry which is the fastest in development.
At present, various enterprises design various forms of liquid path systems according to the same working principle, and the liquid path system of a biochemical analyzer mainly realizes the following functions: filling and cleaning of a sample, filling and cleaning of a reagent, cleaning of a stirring rod, cleaning of a reaction cup, filling of a cleaning liquid, waste liquid treatment of a needle, waste liquid treatment of condensed water, waste liquid treatment of the reaction cup, emptying of a whole machine liquid path system and maintenance of a corrosive pipeline.
In the prior art, liquid path modules with different test speeds cannot be compatible, devices are various and unstable in performance, and the cost and the after-sale maintenance difficulty are increased; air dissolved in water is stripped using expensive vacuum pumps and degassing membranes; the inner wall and the outer wall of the needle are cleaned by using a large-flow magnetic centrifugal pump and a gear pump, the magnetic centrifugal pump and the gear pump need to work uninterruptedly, and the requirements on service life and cost are high; the micro magnetic excitation pump and the quantitative pump are used for circulating and filling the cleaning fluid of the whole machine, a filling loop is not needed, and the ageing and crystallization blockage of the pipeline can be accelerated when the instrument is not used for a long time; the structure of the waste liquid of the hand pump for cleaning is complex or simple, which causes over high cost or incomplete waste liquid pumping; the filling structure of the reaction cup is complex or simple, which causes too high cost or washing hand dropping liquid; the diaphragm pump is used for pumping and discharging the waste liquid of the whole machine, the pump load is large, and the diaphragm is easy to be worn or bonded by reactants.
Disclosure of Invention
In view of this, the present invention provides a liquid path system of a full-automatic biochemical analyzer, which has a simple and reliable structure, stable water pressure, fast response speed, complete functions, low cost, strong maintainability, and compatibility with different testing speeds.
The invention solves the technical problems by the following technical means:
a fully automated biochemical analyzer fluid path system, comprising:
the water adding module is used for maintaining the water pressure of the liquid path system;
the sample adding and cleaning module is used for sucking and adding samples and reagents and cleaning sample needles and reagent needles;
the reaction cup cleaning module is used for cleaning the reaction cup;
the waste liquid collecting module is used for collecting waste liquid;
the water adding module comprises a water storage unit and a pressurizing unit connected with the water storage unit, the sample adding cleaning module comprises a sample adding needle cleaning unit, a reagent needle cleaning unit and a stirring rod cleaning unit, the reaction cup cleaning module comprises a reaction cup cleaning liquid path unit and a double-end negative pressure pump, the reaction cup cleaning liquid path unit and the double-end negative pressure pump are both communicated with the interior of the reaction cup, the waste liquid collecting module comprises a waste liquid collecting unit and a reagent refrigerating chamber condensing pipeline communicated with the waste liquid collecting unit, the water outlet ends of the sample adding needle cleaning unit, the reagent needle cleaning unit and the stirring rod cleaning unit are communicated with a condensation pipeline of the reagent refrigerating chamber, the water outlet end of the double-head negative pressure pump is communicated with the waste liquid collecting unit, and the sample adding needle cleaning unit, the reagent needle cleaning unit, the stirring rod cleaning unit and the reaction cup cleaning liquid path unit are all connected in parallel on the water outlet of the pressurizing unit.
Further, the water storage unit comprises an external water inlet barrel and a first liquid level sensor arranged in the external water inlet barrel, the pressurizing unit comprises a water inlet valve, a gear pump, a pressure detection device, a bag type pressure tank and a heating tank which are sequentially connected, the water inlet valve is communicated with the external water inlet barrel, and the heating tank is provided with the water outlet.
Further, a filter is further installed between the water inlet valve and the external water inlet barrel.
The liquid path system of a full-automatic biochemical analyzer, wherein: the sample adding needle cleaning unit comprises a sample adding needle inner wall washing pipeline and a sample adding needle outer wall washing pipeline which are connected in sequence, the reagent needle cleaning unit comprises a plurality of one-to-one reagent needle inner wall washing pipelines and a plurality of reagent needle outer wall washing pipelines, the stirring rod cleaning unit comprises a plurality of stirring rods washing pipelines, a three-way pipe is installed on a water outlet of the pressurizing unit, a water inlet end of the sample adding needle inner wall washing pipeline and a water inlet end of the reagent needle inner wall washing pipeline are communicated with one end of the three-way pipe, an air-vent valve is installed on the remaining end of the three-way pipe, and the sample adding needle outer wall washing pipeline, the reagent needle outer wall washing pipeline and the stirring rod washing pipeline are communicated with a water outlet end of.
Further, the sample adding needle inner wall washing pipeline comprises a sample adding needle inner wall washing electromagnetic valve, an inner wall precise pressure sensor, a sample adding plunger pump and a sample adding needle which are sequentially communicated, the sample adding needle outer wall washing pipeline comprises a sample adding needle outer wall washing electromagnetic valve and a sample adding needle washing nozzle communicated with the sample adding needle outer wall washing electromagnetic valve, the water inlet end of the sample adding needle outer wall washing electromagnetic valve is communicated with the water outlet end of the pressure regulating valve, and the bottom of the sample adding needle washing nozzle is provided with a pipeline communicated with the reagent refrigerating chamber condensation pipeline.
Further, the reagent needle inner wall washing pipeline comprises a reagent needle washing electromagnetic valve, a reagent plunger pump and a reagent needle which are sequentially communicated, the reagent needle outer wall washing pipeline comprises a reagent needle outer wall washing electromagnetic valve and a reagent needle washing spray head communicated with the reagent needle outer wall washing electromagnetic valve, and a pipeline is arranged at the bottom of the reagent needle washing spray head and communicated with a reagent refrigerating chamber condensation pipeline.
Further, the stirring rod flushing pipeline comprises a stirring rod cleaning electromagnetic valve and a cleaning tank connected with the stirring rod cleaning electromagnetic valve, the water inlet end of the stirring rod cleaning electromagnetic valve is communicated with the water outlet end of the pressure regulating valve, and a pipeline communicated with the reagent refrigerating chamber condensation pipeline is arranged at the bottom of the cleaning tank.
Further, reaction cup washing liquid way unit includes backward flow liquid way and washing liquid way, the backward flow liquid way includes tee bend backward flow solenoid valve, three clear water injection pipes and outlet pipe, clear water injection pipe and outlet pipe are installed on tee bend backward flow solenoid valve's both ends mouth, tee bend backward flow solenoid valve's the end of intaking with the play water end of air-vent valve is linked together, the play water end of clear water injection pipe is located inside the reaction cup, the outlet pipe is linked together with reagent walk chamber condensation pipeline, washing liquid way is including the washing liquid holding vessel, washing liquid tee bend solenoid valve, washing liquid pump and the washing liquid valve that connect gradually, install the washing liquid pipe on the delivery port of washing liquid valve, the end of washing liquid pipe is located inside the reaction cup, the remaining one end of washing liquid tee bend solenoid valve with the play water end of air-vent valve is linked together.
Further, the waste liquid collecting unit comprises a waste liquid collecting barrel and a second liquid level sensor installed in the waste liquid collecting barrel.
Further, the waste liquid collecting barrel is provided with an air vent.
The invention has the beneficial effects that:
according to the liquid path system of the full-automatic biochemical analyzer, the pump, the bag-type pressure tank, the electromagnetic valve, the pressure regulating valve, the double-head negative pressure pump and the like in each module are all mature devices with simple and stable performance, the performance of the devices and a common physical principle are fully utilized to meet the functional requirements of the machine, the structure and the control are simplified, and therefore the stability of the system is improved and the cost is greatly reduced; the bag-type pressure tank can store and buffer energy, so that the water pressure is stable, the response speed is high, the solubility of air in water is increased, and a high-cost degassing device is omitted; the compatibility of 200-800 speeds can be quickly realized by changing the specifications of the water pump and the filter and increasing or deleting the quantity of the electromagnetic valves and the cleaning tanks; the cleaning hand dripping and cleaning liquid crystallization problems are solved by utilizing the three-way electromagnetic valve and the communicating vessel principle; the performance of higher instantaneous negative pressure is provided by the double-head negative pressure pump, so that a complex negative pressure storage device and a gas-liquid separation device are omitted; the height difference of the instrument and the large-caliber waste liquid pipeline are utilized to realize the self-flow of the dilute waste liquid, and a waste liquid pump is saved.
Drawings
FIG. 1 is a schematic structural diagram of a liquid path system of a full-automatic biochemical analyzer according to the present invention.
FIG. 2 is a schematic structural diagram of a water adding module in a liquid path system of a full-automatic biochemical analyzer according to the present invention.
Fig. 3 is a schematic structural diagram of a sample loading and cleaning module in a liquid path system of a full-automatic biochemical analyzer according to the present invention.
FIG. 4 is a schematic structural diagram of a reaction cup cleaning module in a liquid path system of a full-automatic biochemical analyzer according to the present invention.
FIG. 5 is a schematic structural diagram of a waste liquid collection module in a liquid path system of a full-automatic biochemical analyzer according to the present invention.
Detailed Description
The invention will be described in detail below with reference to the following figures and specific examples:
as shown in fig. 1, the liquid path system of a full-automatic biochemical analyzer of the present invention comprises:
a water adding module 100 for maintaining the water pressure of the liquid path system, a sample adding and cleaning module 200 for sucking and adding samples and reagents and cleaning sample needles and reagent needles, a reaction cup cleaning module 300 for cleaning reaction cups, and a waste liquid collecting module 400 for collecting waste liquid;
the water adding module 100 comprises a water storage unit and a pressurizing unit connected with the water storage unit, the sample adding cleaning module 200 comprises a sample adding needle cleaning unit, a reagent needle cleaning unit and a stirring rod cleaning unit, the reaction cup washing module 300 includes a reaction cup washing liquid path unit and a double-headed negative pressure pump 33, the reaction cup cleaning liquid path unit and the double-head negative pressure pump 33 are communicated with the interior of the reaction cup, the waste liquid collecting module 400 comprises a waste liquid collecting unit and a reagent refrigerating chamber condensation pipeline communicated with the waste liquid collecting unit, the water outlet ends of the sample adding needle cleaning unit, the reagent needle cleaning unit and the stirring rod cleaning unit are communicated with a condensation pipeline of the reagent refrigerating chamber, the water outlet end of the double-head negative pressure pump 33 is communicated with the waste liquid collecting unit, and the sample adding needle cleaning unit, the reagent needle cleaning unit, the stirring rod cleaning unit and the reaction cup cleaning liquid path unit are all connected in parallel on the water outlet of the pressurizing unit.
Specifically, as shown in fig. 2, the water storage unit includes an external water inlet barrel 34 and a first liquid level sensor 35 installed in the external water inlet barrel 34, the pressurizing unit includes a water inlet valve 1, a gear pump 2, a pressure detecting device 3, a bag-type pressure tank 4 and a heating tank 5 which are connected in sequence, the water inlet valve 1 is communicated with the external water inlet barrel 34, the heating tank 5 is provided with the water outlet, and a filter 40 is further installed between the water inlet valve 1 and the external water inlet barrel 34. Leading-in bag formula overhead tank 4 is as the energy storage component of whole liquid way system, environmental protection rubber diaphragm is with gas and water isolation, the mechanical energy that gas absorption and buffering gear pump 2 provided in the jar, extrude each delivery port with water, make inside water pressure maintain steadily at the settlement within range, gear pump 2 only needs intermittent type action, great extension gear pump 2 life-span, high to component availability factor, and inside great water pressure that keeps, it is fast to go out water response speed, increase air solubility, prevent that aquatic gas from spilling over, save degasser such as expensive defoaming membrane and negative pressure pump.
Further, the application of sample needle cleaning unit washes the pipeline and the application of sample needle outer wall washes the pipeline including the application of sample needle inner wall that connects gradually, reagent needle cleaning unit includes that many one-to-one's reagent needle inner wall washes the pipeline and the reagent needle outer wall washes the pipeline, the stirring rod cleaning unit includes that many stirring rods wash the pipeline, install the three-way pipe on the delivery port of pressurizing unit, the application of sample needle inner wall washes the water inlet end of pipeline, the reagent needle inner wall washes the water inlet end of pipeline all to be linked together with the one end of three-way pipe, install air-vent valve 6 on the remaining one end of three-way pipe, application of sample needle outer wall washes pipeline, reagent needle outer wall and the stirring rod washes the pipeline and all communicates with the play water end of.
Specifically, as shown in fig. 3, in this embodiment, the sample-adding needle inner wall flushing pipeline includes a sample-adding needle inner wall flushing solenoid valve 8, an inner wall precise pressure sensor 10, a sample-adding plunger pump 12 and a sample-adding needle 15 which are sequentially communicated, the sample-adding needle outer wall flushing pipeline includes a sample-adding needle outer wall cleaning solenoid valve 25 and a sample-adding needle cleaning nozzle 20 communicated with the sample-adding needle outer wall cleaning solenoid valve 25, a water inlet end of the sample-adding needle outer wall cleaning solenoid valve 25 is communicated with a water outlet end of the pressure regulating valve 6, and a pipeline communicated with the reagent refrigerating chamber condensation pipeline is arranged at the bottom of the sample-adding needle cleaning.
Specifically, when the sample needle 15 rotates to a position above a sample sucking position of the sample tray, the sample adding plunger pump 12 sucks a certain amount of air, the liquid level sensing plate accurately controls the sample needle 15 to descend, the sample needle continues to descend X3mm after contacting the liquid level, the sample adding plunger pump 12 sucks an X4 μ L sample and a certain surplus sample amount, the plunger pump 12 reversely pumps out a part of the sample to eliminate a plunger pump reversal gap, then the sample needle 15 is lifted from the sample tray and rotates to a designated reaction cup, and the sample adding plunger pump 12 is controlled to pump out an X4 μ L sample.
Specifically, when sample needle 15 rotates to the position of sample-adding needle cleaning nozzle 20, the power is turned on simultaneously to open sample-adding needle inner wall washing solenoid valve 8 and sample-adding needle outer wall washing solenoid valve 25 for cleaning, sample-adding plunger pump 12 pumps out the surplus sample amount, the power is turned off firstly to close sample-adding needle inner wall washing solenoid valve 8, and then the power is turned off to close sample-adding needle outer wall washing solenoid valve 25, the needle head is washed by using external water flow, the hanging of the needle tip of sample-adding needle 15 is prevented, the inner wall washing solenoid valve 8 is turned on, the inner wall precision pressure sensor 10 detects the washing water pressure fluctuation curve, whether the needle blocking phenomenon exists is judged, and therefore the cleaning of sample-adding.
Specifically, as shown in fig. 3, in this embodiment the reagent needle inner wall washing pipeline includes that the reagent needle inner wall washes pipeline and the two needle inner walls of reagent and washes the pipeline, the reagent needle washes the pipeline including the two needle of reagent that are linked together in proper order wash solenoid valve 7, reagent needle plunger pump 13 and reagent needle 14, the two needle inner walls of reagent wash the pipeline including the two needle of reagent that are connected gradually wash solenoid valve 9, two needle plunger pumps 11 of reagent and two needles 16 of reagent, with the reagent needle inner wall washes the pipeline corresponding, the reagent needle outer wall washes the pipeline including the two needle outer walls of reagent wash pipeline and two needle outer walls of reagent wash the pipeline, the reagent needle outer wall washes the pipeline including reagent needle outer wall washing solenoid valve 24 and the reagent needle that is linked together with reagent needle outer wall washing solenoid valve 24 and washs shower nozzle 19, two needle outer wall washing pipelines of reagent include that the two needle outer walls of reagent wash solenoid valve 26 and wash the two needle And the bottom of the reagent needle cleaning spray head 19 and the bottom of the reagent needle cleaning spray head 21 are provided with pipelines communicated with a condensation pipeline of the reagent refrigerating chamber.
Specifically, when a reagent needle 14 rotates to a position above a reagent dish sucking sample position, after a reagent needle plunger pump 13 sucks quantitative air, a liquid level sensing plate accurately controls a sample adding needle to descend, the sample adding needle continues to descend X5mm after contacting a liquid level, after the reagent needle plunger pump 13 sucks X6 muL of reagent and a certain surplus reagent amount, the reagent needle plunger pump 13 reversely pumps part of the reagent to eliminate a reverse gap of the reagent needle plunger pump 13, then the reagent needle 14 is lifted from the reagent dish and rotates to a specified reaction cup, and the reagent needle plunger pump 13 pumps an X6 muL of sample.
Further, when reagent needle 14 is rotatory to reagent needle and washs 19 positions, the circular telegram opens reagent needle inner wall and washes solenoid valve 7 and reagent needle outer wall washing solenoid valve 24 and wash simultaneously, reagent needle plunger pump 13 is beaten out reagent surplus reagent volume, the outage is closed earlier reagent needle inner wall and is washed solenoid valve 7 and the outage is closed reagent needle outer wall and wash solenoid valve 24 again, utilize outside rivers to erode the syringe needle, prevent 14 needle points of reagent needle and hang liquid, thereby accomplish the washing of reagent needle 14, because of the reagent needle bore is big, and reagent purity is higher, there is not stifled needle phenomenon, need not to detect stifled needle, two needle 46 action processes of reagent are unanimous with reagent needle 14.
In this embodiment, the reagent needle inner wall flushing line and the sample needle inner wall flushing line are one of important maintenance lines in a liquid path system, and the inner wall cleaning pressure is large, and the inner wall line has a small caliber, and cannot be fastened by using a clamp, so that end face sealing with better sealing performance is used, that is, a hot-melt flanging line is used in cooperation with an extrusion joint with higher precision flatness, and the leakage probability is greatly reduced. The pressure regulating valve 6 is a diaphragm type pressure regulating valve, the internal diaphragm automatically regulates the opening and closing width of the valve according to the front and back pressure difference, so that the water outlet pressure of the reagent needle cleaning nozzle 19, the sample adding needle cleaning nozzle 20 and the reagent needle cleaning nozzle 21 is kept constant, and the phenomenon that the cleaning water amount is large or small is avoided.
Specifically, as shown in fig. 3, in this embodiment, the stirring rod flushing pipeline includes a reagent stirring rod flushing pipeline and a sample stirring rod flushing pipeline, the reagent stirring rod flushing pipeline includes a reagent stirring rod cleaning solenoid valve 28 and a first cleaning tank 23 connected to the reagent stirring rod cleaning solenoid valve 28, the sample stirring rod flushing pipeline includes a sample stirring rod cleaning solenoid valve 27 and a second cleaning tank 22 communicated to the sample stirring rod cleaning solenoid valve 27, water inlet ends of the reagent stirring rod cleaning solenoid valve 28 and the sample stirring rod cleaning solenoid valve 27 are both communicated to a water outlet end of the pressure regulating valve 6, and bottoms of the first cleaning tank 23 and the second cleaning tank 22 are both provided with a pipeline communicated to the reagent refrigerating chamber condensation pipeline.
Further, as shown in fig. 4, the reaction cup cleaning liquid path unit includes a backflow liquid path and a cleaning liquid path, the backflow liquid path includes a three-way backflow electromagnetic valve 29, three clean water injection pipes and a water outlet pipe, the clean water injection pipes and the water outlet pipe are respectively installed on two ports of the three-way backflow electromagnetic valve 29, a water inlet end of the three-way backflow electromagnetic valve 29 is communicated with a water outlet end of the pressure regulating valve 6, the water outlet end of the clean water injection pipe is located inside the reaction cup, the water outlet pipe is communicated with a reagent refrigerating chamber condensation pipeline, the cleaning liquid path includes a cleaning liquid storage barrel 36, a cleaning liquid three-way electromagnetic valve 30, a cleaning liquid pump 31 and a cleaning liquid valve 32 which are sequentially connected, a cleaning liquid pipe is installed on a water outlet of the cleaning liquid valve 32, a tail end of the cleaning liquid pipe is located inside the reaction cup, and a remaining end of the cleaning liquid three-way electromagnetic valve, the cleaning solution storage tub 36 is installed therein with a second liquid level sensor 37.
Specifically, before the test starts, a certain number of reaction cups are cleaned, the cleaning hand driving motor rotates, the cleaning hand 41 is lowered to the mouth of the reaction cup, at the moment, the double-end negative pressure pump 33 starts to act, after the cleaning hand 41 is lowered to the bottom of the reaction cup and absorbs waste liquid, the driving motor rotates reversely, the cleaning hand 41 is lifted for a certain distance, at the moment, the cleaning liquid pump 31, the cleaning liquid valve 32 and the three-way backflow electromagnetic valve 29 are electrified for X7 seconds, the cleaning hand driving motor rotates reversely, the cleaning hand 41 is lifted to the top, the double-end negative pressure pump 33 is closed to complete water injection, and the process is repeated for many times until all the reaction cups are cleaned.
In the embodiment, the independent metal pipes are used in the processes of pumping the waste liquid, filling the pure water and the cleaning liquid, and the metal pipe for pumping the waste liquid is slightly longer than the metal pipe for filling, so that the structure can complete the pumping of the waste liquid, the filling of the cleaning liquid and the pure water and the cleaning of the needle point, and the generation of cross contamination during the cleaning of the next sample is prevented. In addition, in the embodiment, the hardness of the one-way diaphragm of the double-head negative pressure pump 33 is improved 30, so that the instantaneous negative pressure of the action of the double-head negative pressure pump 33 is increased, and the reaction cup cleaning effect is ensured under the condition that no pressure storage tank or no pressure storage of a negative pressure sensor still has enough negative pressure strength.
The double-end negative pressure pump 33 works continuously in the water injection process and is used for sucking and leveling the liquid level of the reaction cup, balancing the response error of water injection, keeping the water injection liquid level of the reaction cup at the same horizontal plane, ensuring the blank reading of the cup, and preventing the reaction cup from overflowing.
And, the washing liquid pump 31 is miniature diaphragm pump, the cost of miniature diaphragm pump is low and the stable performance, the filling amount is adjustable, and washing liquid three way solenoid valve 30 is increased to the pipeline of washing liquid pump 31 front end, a switching for washing liquid and pure water, open washing liquid three way solenoid valve 30 after the washing is accomplished, wash a set of reaction cup more, wash the surplus washing liquid in washing liquid pump 31 and the pipeline with the pure water, prevent that the instrument from appearing the phenomenon that the pump valve was blockked up in the washing liquid crystallization after a long time, the pure water has certain pressure, if make the diaphragm bonding of miniature diaphragm pump, can wash away the diaphragm check valve, resume miniature diaphragm pump state.
Further, as shown in fig. 5, the waste liquid collecting unit includes a waste liquid collecting barrel 38 and a second liquid level sensor 39 installed in the waste liquid collecting barrel 38.
The reagent refrigerating chamber condensation pipeline is an acid and alkali corrosion resistant large-caliber pipeline, the matched large-caliber Y-shaped tee joint is communicated with the bottoms of the sample adding needle cleaning spray head 20, the reagent needle cleaning spray head and the cleaning tank, the pipeline is designed to run smoothly structurally, the height difference is utilized to realize gravity flow of wastewater in the sample adding needle cleaning spray head 20, the reagent needle cleaning spray head and the cleaning tank, an air vent is formed in the waste liquid collecting barrel 38, the flow resistance of the wastewater is reduced, and waste liquid emptying is not required to be carried out by a waste liquid pump which is expensive in price and needs to be maintained frequently.
After the instrument is opened, the system judges whether water is stored in an external water inlet barrel 34 through a first liquid level sensor 35, a gear pump 2 and a water adding valve 1 are opened, a pressure detection device 3 continuously detects pressure signals in a bag type pressure tank 4, when the water pressure in the bag type pressure tank 4 rises to a maximum value X1 in a set range, the gear pump 2 and the water adding valve 1 are closed, a reagent needle outer wall cleaning electromagnetic valve 24, a sample adding needle outer wall cleaning electromagnetic valve 25, a reagent second needle outer wall cleaning electromagnetic valve 26, a sample stirring rod cleaning electromagnetic valve 27, a reagent stirring rod cleaning electromagnetic valve 28, a reagent needle cleaning electromagnetic valve 7, a sample adding needle inner wall cleaning electromagnetic valve 8 and a reagent second needle cleaning electromagnetic valve 9 are sequentially opened, the gas in the instrument is evacuated, at the moment, a heating tank 5 starts to heat, the pressure detection device 3 judges whether the water pressure signals are larger than a minimum, therefore, the starting of the gear pump 2 and the water adding valve 1 is controlled, the water pressure in the bag type pressure tank 4, namely the whole machine is always maintained in a set range of X1-X2, the flow of the gear pump 2 is far larger than the water consumption flow of the whole machine, and the water pressure can be increased from X1MPa to X2MPa only in a very short time.
Further, the software sets for the function of first water feeding, whether internal pressure is 0 before detecting the complete machine and intaking through pressure detection device 3, judge whether for first water intaking, utilize water pressure to arrange the inside air of pipeline completely, prevent that gaseous solution from intaking into water, and heat 5 dry combustion method on the jar, influence cleaning performance and application of sample precision, simultaneously, first level sensor 35 detects when the water yield in outside intaking bucket 34 is less, the system can indicate the user to carry out the pure water supply, probably there is the foreign matter to fall into during the supply pure water, so use filter 40 to filter protection complete machine liquid circuit pipeline, prevent that the foreign matter from blockking up liquid circuit pipeline.
Although the present invention has been described in detail with reference to the preferred embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the spirit and scope of the invention as defined in the appended claims. The techniques, shapes, and configurations not described in detail in the present invention are all known techniques.
Claims (10)
1. The utility model provides a full-automatic biochemical analyzer liquid way system which characterized in that: the method comprises the following steps:
the water adding module is used for maintaining the water pressure of the liquid path system;
the sample adding and cleaning module is used for sucking and adding samples and reagents and cleaning sample needles and reagent needles;
the reaction cup cleaning module is used for cleaning the reaction cup;
the waste liquid collecting module is used for collecting waste liquid;
the water adding module comprises a water storage unit and a pressurizing unit connected with the water storage unit, the sample adding cleaning module comprises a sample adding needle cleaning unit, a reagent needle cleaning unit and a stirring rod cleaning unit, the reaction cup cleaning module comprises a reaction cup cleaning liquid path unit and a double-end negative pressure pump, the reaction cup cleaning liquid path unit and the double-end negative pressure pump are both communicated with the interior of the reaction cup, the waste liquid collecting module comprises a waste liquid collecting unit and a reagent refrigerating chamber condensing pipeline communicated with the waste liquid collecting unit, the water outlet ends of the sample adding needle cleaning unit, the reagent needle cleaning unit and the stirring rod cleaning unit are communicated with a condensation pipeline of the reagent refrigerating chamber, the water outlet end of the double-head negative pressure pump is communicated with the waste liquid collecting unit, and the sample adding needle cleaning unit, the reagent needle cleaning unit, the stirring rod cleaning unit and the reaction cup cleaning liquid path unit are all connected in parallel on the water outlet of the pressurizing unit.
2. The liquid path system of a full-automatic biochemical analyzer according to claim 1, wherein the water storage unit comprises an external water inlet barrel and a first liquid level sensor installed in the external water inlet barrel, the pressurizing unit comprises a water inlet valve, a gear pump, a pressure detecting device, a bag-type pressure tank and a heating tank which are connected in sequence, the water inlet valve is communicated with the external water inlet barrel, and the heating tank is provided with the water outlet.
3. The liquid path system of a full-automatic biochemical analyzer according to claim 2, wherein a filter is further installed between the water inlet valve and the external water inlet tank.
4. The liquid path system of a full-automatic biochemical analyzer according to claim 3, wherein: the sample adding needle cleaning unit comprises a sample adding needle inner wall washing pipeline and a sample adding needle outer wall washing pipeline which are connected in sequence, the reagent needle cleaning unit comprises a plurality of one-to-one reagent needle inner wall washing pipelines and a plurality of reagent needle outer wall washing pipelines, the stirring rod cleaning unit comprises a plurality of stirring rods washing pipelines, a three-way pipe is installed on a water outlet of the pressurizing unit, a water inlet end of the sample adding needle inner wall washing pipeline and a water inlet end of the reagent needle inner wall washing pipeline are communicated with one end of the three-way pipe, an air-vent valve is installed on the remaining end of the three-way pipe, and the sample adding needle outer wall washing pipeline, the reagent needle outer wall washing pipeline and the stirring rod washing pipeline are communicated with a water outlet end of.
5. The liquid path system of a full-automatic biochemical analyzer according to claim 4, wherein the sample injection needle inner wall flushing pipeline comprises a sample injection needle inner wall flushing solenoid valve, an inner wall precise pressure sensor, a sample injection plunger pump and a sample injection needle which are sequentially communicated, the sample injection needle outer wall flushing pipeline comprises a sample injection needle outer wall cleaning solenoid valve and a sample injection needle cleaning nozzle communicated with the sample injection needle outer wall cleaning solenoid valve, a water inlet end of the sample injection needle outer wall cleaning solenoid valve is communicated with a water outlet end of the pressure regulating valve, and a pipeline communicated with the reagent refrigerating chamber condensation pipeline is arranged at the bottom of the sample injection needle cleaning nozzle.
6. The liquid path system of a full-automatic biochemical analyzer according to claim 5, wherein the reagent needle inner wall flushing line comprises a reagent needle flushing solenoid valve, a reagent plunger pump and a reagent needle which are sequentially communicated, the reagent needle outer wall flushing line comprises a reagent needle outer wall cleaning solenoid valve and a reagent needle cleaning nozzle communicated with the reagent needle outer wall cleaning solenoid valve, and a pipeline communicated with the reagent refrigerating chamber condensation line is arranged at the bottom of the reagent needle cleaning nozzle.
7. The liquid path system of a full-automatic biochemical analyzer according to claim 6, wherein the stirring rod flushing line comprises a stirring rod cleaning solenoid valve and a cleaning tank connected with the stirring rod cleaning solenoid valve, a water inlet end of the stirring rod cleaning solenoid valve is communicated with a water outlet end of the pressure regulating valve, and a pipe arranged at the bottom of the cleaning tank is communicated with the reagent refrigerating chamber condensation line.
8. The liquid path system of a full-automatic biochemical analyzer according to claim 7, the reaction cup cleaning liquid path unit comprises a return liquid path and a cleaning liquid path, the return liquid path comprises a three-way return electromagnetic valve, three clear water injection pipes and a water outlet pipe, the clean water injection pipe and the water outlet pipe are arranged on two ports of the three-way reflux electromagnetic valve, the water inlet end of the three-way reflux electromagnetic valve is communicated with the water outlet end of the pressure regulating valve, the water outlet end of the clean water injection pipe is positioned in the reaction cup, the water outlet pipe is communicated with a condensation pipeline of the reagent refrigerating chamber, the cleaning liquid path comprises a cleaning liquid storage barrel, a cleaning liquid three-way electromagnetic valve, a cleaning liquid pump and a cleaning liquid valve which are connected in sequence, and a cleaning liquid pipe is arranged on a water outlet of the cleaning liquid valve, the tail end of the cleaning liquid pipe is positioned in the reaction cup, and the remaining end of the cleaning liquid three-way electromagnetic valve is communicated with the water outlet end of the pressure regulating valve.
9. The fluid path system of claim 8, wherein the waste liquid collecting unit comprises a waste liquid collecting barrel and a second liquid level sensor installed in the waste liquid collecting barrel.
10. The fluid path system of claim 9, wherein the waste fluid collecting barrel is provided with a vent.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910212314.0A CN111721956A (en) | 2019-03-20 | 2019-03-20 | Liquid path system of full-automatic biochemical analyzer |
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| CN201910212314.0A CN111721956A (en) | 2019-03-20 | 2019-03-20 | Liquid path system of full-automatic biochemical analyzer |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113695322A (en) * | 2021-08-31 | 2021-11-26 | 中元汇吉生物技术股份有限公司 | Sampling needle cleaning device and cleaning method thereof |
| CN113714213A (en) * | 2021-07-22 | 2021-11-30 | 深圳国赛优瑞医疗科技有限公司 | Spray abluent pipeline structure |
| CN113917132A (en) * | 2021-10-09 | 2022-01-11 | 中元汇吉生物技术股份有限公司 | Liquid path system and luminous immunoassay analyzer thereof |
| WO2023098393A1 (en) * | 2021-12-03 | 2023-06-08 | 中翰盛泰生物技术股份有限公司 | Liquid path system for immunodetection |
-
2019
- 2019-03-20 CN CN201910212314.0A patent/CN111721956A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113714213A (en) * | 2021-07-22 | 2021-11-30 | 深圳国赛优瑞医疗科技有限公司 | Spray abluent pipeline structure |
| CN113714213B (en) * | 2021-07-22 | 2022-07-12 | 深圳国赛优瑞医疗科技有限公司 | Spray abluent pipeline structure |
| CN113695322A (en) * | 2021-08-31 | 2021-11-26 | 中元汇吉生物技术股份有限公司 | Sampling needle cleaning device and cleaning method thereof |
| CN113917132A (en) * | 2021-10-09 | 2022-01-11 | 中元汇吉生物技术股份有限公司 | Liquid path system and luminous immunoassay analyzer thereof |
| WO2023098393A1 (en) * | 2021-12-03 | 2023-06-08 | 中翰盛泰生物技术股份有限公司 | Liquid path system for immunodetection |
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