CN112904030A

CN112904030A - Liquid supply system and method thereof

Info

Publication number: CN112904030A
Application number: CN201911218036.6A
Authority: CN
Inventors: 孙娟娟
Original assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Current assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date: 2019-12-03
Filing date: 2019-12-03
Publication date: 2021-06-04

Abstract

A liquid supply system and method thereof, the system includes a plurality of external liquid storage barrels, a manifold block, a first liquid supply pipeline, a valve component, a buffer container, a second liquid supply pipeline and a processor; the first liquid supply pipeline is connected between the external liquid storage barrels and the confluence block and is used for conveying liquid on each external liquid storage barrel to the confluence block, and a valve assembly for controlling the liquid flow between the external liquid storage barrels and the confluence block is further arranged on the first liquid supply pipeline; the second liquid supply pipeline is connected between the confluence block and the buffer container, and is provided with a pressure source for generating liquid discharge pressure of the external liquid storage barrels to the buffer container and a detection unit for detecting the liquid condition on each external liquid storage barrel; when the liquid supply system starts external liquid supply, the liquid supply system can control the sample analysis devices to perform external liquid supply according to the load state of each sample analysis device.

Description

Liquid supply system and method thereof

Technical Field

The invention relates to a liquid supply system and a method thereof.

Background

The sample analyzer is used for detecting and analyzing specific biological components, chemical substances and the like contained in a sample, and in order to avoid sample cross contamination, a dispensing needle is cleaned after sampling and sample adding are finished, and the dispensing needle can perform next sampling and sample adding actions after cleaning is finished.

An immunoassay device is not taken as an example, and the immunoassay device is generally provided with a cleaning solution for cleaning a needle pipeline to meet the requirements of cleaning a sampling needle and the like. The introduction sources of the cleaning solution are two types: one is connected to a deionized water pipeline in a department room, and the instrument controls a switch valve to realize whether water enters or not according to the test requirement; one is a barrel storing cleaning liquid, the instrument is designed to be provided with the built-in barrel at the beginning to supply the cleaning liquid to the instrument, and when the cleaning liquid in the barrel is exhausted, the instrument alarms to inform a user of replacement.

There are areas where these solutions for cleaning liquid supply are needed to be improved.

Disclosure of Invention

The invention provides a liquid supply system and a method thereof, which are used for realizing self-adaptive liquid supply and reducing user interaction.

According to a first aspect, there is provided in an embodiment a liquid supply system comprising:

a plurality of external liquid storage barrels arranged outside the sample analysis device and used for storing cleaning liquid;

the confluence block is arranged outside the sample analysis device and is used for pooling the liquid on the external liquid storage barrels;

the first liquid supply pipeline is arranged outside the sample analysis device, is connected between the external liquid storage barrels and the confluence block and is used for conveying liquid on each external liquid storage barrel to the confluence block;

the valve assembly is arranged outside the sample analysis device, is arranged on the first liquid supply pipeline and is used for controlling the liquid flow between each external liquid storage barrel and the confluence block;

a buffer container for storing the cleaning liquid transferred from the manifold block so that the sample analyzer can extract the cleaning liquid from the buffer container to clean the dispensing needle; wherein, the buffer container is respectively connected with the cleaning components on the plurality of sample analysis devices;

the second liquid supply pipeline is connected between the confluence block and the buffer container, a pressure source and a detection unit are arranged on the second liquid supply pipeline, the pressure source is arranged between the detection unit and the buffer container, the pressure source is used for generating the pressure of the liquid discharged from the external liquid storage barrel to the buffer container, and the detection unit is used for detecting the liquid condition on each external liquid storage barrel, so that when the external liquid storage barrel discharges the liquid to the buffer container, the valve assembly can be switched according to the liquid condition on each external liquid storage barrel;

and the processor is used for controlling the sample analysis device to carry out external liquid supply according to the load state of each sample analysis device when the external liquid supply is started.

In one embodiment, the processor controls the external liquid supply to the sample analyzer according to the load status of each sample analyzer, comprising:

when part of the sample analysis devices are in a test state and the part of the sample analysis devices are in an idle state, the processor controls to reserve a preset number of external liquid storage barrels for each idle-state sample analysis device, and distributes the rest external liquid storage barrels to supply liquid to the sample analysis devices in the test state.

In one embodiment, the processor controls the external liquid supply to the sample analyzer according to the load status of each sample analyzer, and further includes:

and when the external liquid storage barrel distributed to the sample analysis device in the test state is in an empty state, the processor controls the external liquid storage barrel reserved for the sample analysis device in the idle state to supply liquid to the sample analysis device in the test state.

the processor controls an external liquid storage barrel reserved for the sample analysis device in the idle state, and before liquid supply is carried out on the sample analysis device in the test state, the processor also judges whether the external liquid storage barrel reserved for the sample analysis device in the idle state is set to be in a releasable state or not;

if the sample analyzer is in the idle state, the processor controls an external liquid storage barrel reserved for the sample analyzer in the idle state to supply liquid to the sample analyzer in the test state.

In one embodiment, the processor obtains historical liquid consumption data of each analysis device to calculate the preset number corresponding to each analysis device.

each sample analysis device is provided with a corresponding external liquid storage barrel in advance;

and the processor controls the corresponding external liquid storage barrel to supply liquid to the corresponding sample analysis device in the test state.

and when the external liquid storage barrel corresponding to the sample analysis device in the testing state is in an empty state, the processor controls the external liquid storage barrel corresponding to the sample analysis device in the idle state to supply liquid to the sample analysis device in the testing state.

the processor controls the external liquid storage barrel corresponding to the sample analysis device in the idle state, and before liquid supply is carried out on the sample analysis device in the test state, the processor also judges whether the external liquid storage barrel corresponding to the sample analysis device in the idle state is set to be in a releasable state;

if so, the processor controls the external liquid storage barrel corresponding to the sample analysis device in the idle state to supply liquid to the sample analysis device in the test state.

and when the residual liquid amount of the external liquid storage barrels is judged to be insufficient to support each sample analysis device in the test state at present, the processor supplies liquid to each sample analysis device in the test state according to the priority of each sample analysis device.

In one embodiment, the processor determines the priority of the sample analysis device based on the sample priority.

In one embodiment, the processor determines a priority of the sample analysis device based on the sample priority, comprising: the more samples of the sample analysis device that are of high sample priority, the higher the priority of the sample analysis device.

In one embodiment, the processor determines the priority of the sample analysis device based on the item priority.

In one embodiment, the processor determines a priority of the sample analysis device based on the item priority, comprising: the more items of the sample analyzer having a high item priority, the higher the priority of the sample analyzer.

In one embodiment, the processor determines a priority of the sample analysis device based on the item priority, comprising: the more items in the preset set of items in the sample analysis device, the higher the priority of the sample analysis device.

In one embodiment, the processor supplies the sample analyzer in the test state according to the priority of the sample analyzer, including:

and the processor controls the external liquid storage barrel to preferentially supply liquid to the sample analysis device with high priority.

and when the residual liquid amount of the external liquid storage barrels is judged to be insufficient to support each sample analysis device in the test state at present, the processor supplies liquid to each sample analysis device in the test state according to the sample related priority.

In one embodiment, the processor supplies the sample analyzer in each of the test states according to the sample-related priority, including:

the sample correlation priority comprises a sample priority;

the processor controls the external liquid storage barrel to preferentially supply liquid to items of high-priority samples in the sample analysis device in the test state.

the sample related priorities include item priorities;

and the processor controls the external liquid storage barrel to preferentially supply liquid to the items with high priority in the sample analysis device in the test state.

According to a second aspect, an embodiment provides a method of providing a liquid supply system for externally supplying liquid to a plurality of sample analysis devices; the liquid supply system comprises a plurality of external liquid storage barrels, and the external liquid storage barrels are arranged outside the sample analysis device and used for storing cleaning liquid; the method comprises the following steps:

when external liquid supply is started, acquiring the load state of each sample analysis device;

and controlling external liquid supply to the sample analysis device according to the load state of each sample analysis device.

In one embodiment, the controlling the external liquid supply to the sample analyzer according to the load status of the sample analyzer includes:

when part of the sample analysis devices are in a test state and the part of the sample analysis devices are in an idle state, the preset number of external liquid storage barrels are reserved for each idle-state sample analysis device, and the rest external liquid storage barrels are distributed to supply liquid to the sample analysis devices in the test state.

In one embodiment, the controlling the external liquid supply to the sample analyzer according to the load status of the sample analyzer further includes:

and when the external liquid storage barrel distributed to the sample analysis device in the testing state is judged to be in an empty state, controlling the external liquid storage barrel reserved for the sample analysis device in the idle state to supply liquid to the sample analysis device in the testing state.

In one embodiment, the method for controlling external liquid supply to a sample analyzer according to a load state of the sample analyzer further includes:

controlling an external liquid storage barrel reserved for the sample analysis device in the idle state, and before liquid supply is carried out on the sample analysis device in the test state, judging whether the external liquid storage barrel reserved for the sample analysis device in the idle state is set to be in a releasable state;

if the sample analysis device is in the idle state, the external liquid storage barrel reserved for the sample analysis device is controlled to supply liquid to the sample analysis device in the test state.

In one embodiment, historical liquid consumption data of each analysis device is obtained to calculate a preset number corresponding to each analysis device.

In one embodiment, controlling external liquid supply to a sample analyzer based on a load state of the sample analyzer includes:

and controlling the corresponding external liquid storage barrel to supply liquid to the corresponding sample analysis device in the test state.

and when the external liquid storage barrel corresponding to the sample analysis device in the testing state is in an empty state, controlling the external liquid storage barrel corresponding to the sample analysis device in the idle state to supply liquid to the sample analysis device in the testing state.

controlling an external liquid storage barrel corresponding to the sample analysis device in the idle state, and before supplying liquid to the sample analysis device in the test state, judging whether the external liquid storage barrel corresponding to the sample analysis device in the idle state is set to be in a releasable state;

and if so, controlling the external liquid storage barrel corresponding to the sample analysis device in the idle state to supply liquid to the sample analysis device in the test state.

and when the residual liquid amount of the external liquid storage barrels is judged to be insufficient to support each sample analysis device in the test state at present, controlling the external liquid storage barrels to preferentially supply liquid to the sample analysis devices with high priority.

In one embodiment, the more samples of the sample analysis device that are of high sample priority, the higher the priority of the sample analysis device.

In one embodiment, the priority of the sample analysis device is determined based on the item priority.

In one embodiment, prioritizing the sample analysis devices according to item priorities includes: the more items of the sample analyzer having a high item priority, the higher the priority of the sample analyzer.

In one embodiment, prioritizing the sample analysis devices according to item priorities includes: the more items in the preset set of items in the sample analysis device, the higher the priority of the sample analysis device.

and when the residual liquid amount of the external liquid storage barrels is judged to be insufficient to support each sample analysis device in the test state at present, supplying liquid to each sample analysis device in the test state according to the sample related priority.

In one embodiment, a method for providing liquid to a sample analyzer in a test state according to sample-related priorities includes:

the sample correlation priority comprises a sample priority;

and controlling the external liquid storage barrel to preferentially supply liquid to items of high-priority samples in the sample analysis device in the test state.

the sample related priorities include item priorities;

and controlling the external liquid storage barrel to preferentially supply liquid to the items with high priority in each sample analysis device in the test state.

According to a third aspect, an embodiment provides a computer readable storage medium comprising a program executable by a processor to implement a method as described in any of the embodiments herein.

The invention provides a liquid supply system and a method thereof, wherein the system comprises a plurality of external liquid storage barrels, a confluence block, a first liquid supply pipeline, a valve component, a buffer container, a second liquid supply pipeline and a processor; the first liquid supply pipeline is connected between the external liquid storage barrels and the confluence block and is used for conveying liquid on each external liquid storage barrel to the confluence block, and a valve assembly for controlling the liquid flow between the external liquid storage barrels and the confluence block is further arranged on the first liquid supply pipeline; the second liquid supply pipeline is connected between the confluence block and the buffer container, and is provided with a pressure source for generating liquid discharge pressure of the external liquid storage barrels to the buffer container and a detection unit for detecting the liquid condition on each external liquid storage barrel; when the liquid supply system starts external liquid supply, the liquid supply system can control the sample analysis devices to carry out external liquid supply according to the load state of each sample analysis device, and self-adaptive liquid supply is realized.

Drawings

FIG. 1 is a schematic view of a liquid supply system according to an embodiment;

FIG. 2 is a schematic diagram of a liquid supply system in accordance with another embodiment;

FIG. 3 is a schematic view of a liquid supply system in accordance with yet another embodiment;

FIG. 4 is a schematic view of a liquid supply system in accordance with still another embodiment;

FIG. 5 is a schematic view of a liquid supply system according to yet another embodiment;

FIG. 6 is a schematic view of a liquid supply system according to another embodiment;

FIG. 7 is a schematic illustration of a liquid supply system in accordance with yet another embodiment;

FIG. 8 is a schematic view of a liquid supply system in accordance with still another embodiment;

FIG. 9 is a structural schematic of a liquid supply system in accordance with yet another embodiment;

FIG. 10 is a structural schematic of a liquid supply system according to another embodiment;

FIG. 11 is a schematic view of a liquid supply system in accordance with yet another embodiment;

FIG. 12 is a structural schematic of a liquid supply system in accordance with yet another embodiment;

FIG. 13 is a structural schematic of a liquid supply system in accordance with yet another embodiment;

FIG. 14 is a flow chart of a method of a liquid supply system of an embodiment.

Detailed Description

The present invention will be described in further detail with reference to the following detailed description and accompanying drawings. Wherein like elements in different embodiments are numbered with like associated elements. In the following description, numerous details are set forth in order to provide a better understanding of the present application. However, those skilled in the art will readily recognize that some of the features may be omitted or replaced with other elements, materials, methods in different instances. In some instances, certain operations related to the present application have not been shown or described in detail in order to avoid obscuring the core of the present application from excessive description, and it is not necessary for those skilled in the art to describe these operations in detail, so that they may be fully understood from the description in the specification and the general knowledge in the art.

Furthermore, the features, operations, or characteristics described in the specification may be combined in any suitable manner to form various embodiments. Also, the various steps or actions in the method descriptions may be transposed or transposed in order, as will be apparent to one of ordinary skill in the art. Thus, the various sequences in the specification and drawings are for the purpose of describing certain embodiments only and are not intended to imply a required sequence unless otherwise indicated where such sequence must be followed.

The numbering of the components as such, e.g., "first", "second", etc., is used herein only to distinguish the objects as described, and does not have any sequential or technical meaning. The term "connected" and "coupled" when used in this application, unless otherwise indicated, includes both direct and indirect connections (couplings).

The sample analysis device has the advantages that the problem of the exhausted cleaning solution is not worried about by connecting the deionized water pipeline in the department, but the disadvantage is that the cleaning solution can affect the sample detection, because microorganisms in the water supplied by the deionized water pipeline can interfere with the sample detection, and particularly for some items with high detection sensitivity, the immunoassay item is typical. Therefore, the current sample analysis device generally adopts a mode of internally arranging a cleaning liquid barrel, namely, the closed cleaning liquid barrel produced by a manufacturer is arranged in the device and is connected with a cleaning pipeline of an instrument; correspondingly, because adopt the mode of barreling, consequently need accomplish in the bucket when the washing liquid runs out and in time change new washing liquid bucket, especially when the test ratio of instrument is great, need pay attention to constantly and change the washing liquid bucket many times, this can consume a large amount of time and energy, if change untimely, still can make the instrument pause test, lead to the instrument idle.

In order to increase the number of on-machine tests that the washing liquid supports for sample analysis device can continuous operation, simultaneously in order to reduce the change number of times of built-in stock solution bucket in order to improve staff's work efficiency, this application provides a liquid supply system, provides the washing liquid through setting up at the outside stock solution bucket of sample analysis device to sample analysis device. In a clinical laboratory, a plurality of sample analyzers are generally available, and for economic and space reasons, the present application provides a liquid supply system capable of supplying a cleaning liquid to one or more sample analyzers. In order to realize self-adaptive liquid supply and reduce user interaction, the liquid supply system provided by the application can control external liquid supply to the sample analysis device according to the load state of the sample analysis device. The liquid supply system and the method thereof provided by the present application will be described in detail by specific embodiments.

Liquid supply systems are disclosed in some embodiments, and the liquid supply systems of the present application can supply one or more sample analysis devices, as described in more detail below.

In some embodiments, referring to fig. 1 to 13, the liquid supply system may include a first liquid supply pipeline 100, a second liquid supply pipeline 200, a buffer container 40, a valve assembly, a manifold block 20, a plurality of external liquid storage barrels 10, and a processor 70, wherein the first liquid supply pipeline 100, the valve assembly, the manifold block 20, and the plurality of external liquid storage barrels 10 are all disposed outside the sample analysis apparatus, which not only facilitates replacement of the external liquid storage barrels 10, but also facilitates connection of the external liquid storage barrels 10 to a cleaning assembly 400 of the sample analysis apparatus through the second liquid supply pipeline 200, so as to ensure that a sufficient amount of cleaning liquid is supplied for cleaning the dispensing needle.

Specifically, the plurality of external liquid storage tanks 10 are used for storing cleaning liquid; the confluence block 20 is used for pooling the liquids in the plurality of external liquid storage barrels 10; a valve assembly disposed on the first liquid supply line for controlling the flow of liquid between each of the outer liquid storage barrels 10 and the manifold block 20; the buffer container 40 is used for storing the cleaning liquid transferred from the manifold block 20 so that the sample analyzer can extract the cleaning liquid from the buffer container 40 to clean the dispensing needle; the second fluid supply line 200 is connected between the manifold block 20 and the buffer container 40, and the pressure source 50 and the detection unit 60 are provided on the second fluid supply line 200.

The pressure source 50 is disposed between the detection unit 60 and the buffer container 40, the pressure source 50 is used for generating pressure of the external liquid storage barrel 10 for discharging liquid into the buffer container 40, and the detection unit 60 is used for detecting the liquid condition on each external liquid storage barrel 10, so that when the external liquid storage barrel 10 discharges liquid into the buffer container 40, the valve assembly can be switched according to the liquid condition on each external liquid storage barrel 10.

The dispensing needle includes a sample needle, a reagent needle, a cleaning needle, and the like of the sample analyzer, and after the sample needle, the reagent needle, and the cleaning needle complete sampling or sample application, cleaning is required for next sampling or sample application, and cross contamination is avoided.

After the above technical solution is adopted, when the dispensing needle on the sample analyzer needs to be cleaned, the second liquid supply pipeline 200 transfers the liquid inside the buffer container 40 to the cleaning assembly 400 on the sample analyzer for cleaning the dispensing needle. The liquid in the buffer container 40 is converged to the converging block 20 by the external liquid storage barrel 10 and then transferred through the second liquid supply pipeline 200, and the valve assembly is arranged between the converging block 20 and the external liquid storage barrel 10, so that the processor 70 can select the external liquid storage barrel 10 by controlling the closing or opening of the valve assembly, so as to facilitate the replacement of the external liquid storage barrel 10, and meanwhile, the phenomenon that the air in the buffer container 40 is increased and even a great amount of resources are wasted due to the fact that the pressure source 50 continuously extracts the cleaning liquid to the external liquid storage barrel 10 which is used up by the cleaning liquid can be avoided.

Therefore, the above-mentioned detecting unit 60 is connected between the pressure source 50 and the confluence block 20 for determining the liquid condition in each external liquid storage barrel 10, and if the detecting unit 60 detects that a large amount of cleaning liquid is stored in the external liquid storage barrel 10 being pumped by the current pressure source 50, the processor 70 controls the first liquid supply pipeline 100 to communicate with the external liquid storage barrel 10 being pumped by the current pressure source 50 and the confluence block 20 through the valve assembly; if the detecting unit 60 detects that the cleaning solution in the external liquid storage barrel 10 being pumped by the current pressure source 50 has been consumed, the processor 70 cuts off the communication between the first liquid supply pipeline 100 and the external liquid storage barrel 10 being pumped by the current pressure source 50 and the confluence block 20 through the valve assembly, and opens the communication between the first liquid supply pipeline 100 and the other external liquid storage barrel 10 and the confluence block 20, so that the external liquid storage barrel 10 can continuously confluence the cleaning solution to the confluence block 20 and then transfer the cleaning solution to the buffer container 40 through the second liquid supply pipeline 200.

The buffer container 40 may be provided outside the sample analyzer or inside the sample analyzer, and is provided to supply a cleaning solution to the cleaning module 400 of the sample analyzer, thereby ensuring continuous operation of the sample analyzer.

In an alternative embodiment, the valve assembly includes a plurality of control valves 30, the number of the control valves 30 is matched with the number of the external liquid storage barrels 10, and each control valve 30 is correspondingly disposed to be connected to the first liquid supply line 100. In the present embodiment, the control valves 30 are electrically connected to the processor 70, so that the processor 70 controls the control valve 30 installed on the first liquid supply pipeline 100 to open or close according to the detection result of the detection unit 60, that is, according to the liquid condition on the external liquid storage barrel 10, which not only facilitates the replacement of the external liquid storage barrel 10, but also avoids the problem that the pressure source 50 continues to pump the cleaning liquid into the external liquid storage barrel 10 with the used cleaning liquid, which results in a large amount of waste of resources.

Specifically, each external liquid storage barrel 10 is connected with the confluence block 20 through a first liquid supply pipeline 100, each first liquid supply pipeline 100 is provided with the control valve 30, so as to control the connection or disconnection of the external liquid storage barrel 10 and the confluence block 20, the confluence block 20 is connected to the buffer container 40 through a second liquid supply pipeline 200, the pressure source 50 and the detection unit 60 are installed on the second liquid supply pipeline 200, not only can the number of the pressure source 50 and the detection unit 60 be reduced, and the production cost of the liquid supply system be reduced, but also the liquid condition on each external liquid storage barrel 10 can be monitored in real time, so as to switch the plurality of control valves 30, and simultaneously, a user can replace the external liquid storage barrel 10 which is completely consumed by external cleaning liquid conveniently.

In addition, the positions of the pressure source 50 and the detection unit 60 can be exchanged, in this embodiment, the detection unit 60 is mainly disposed on the side of the second liquid supply pipeline 200 close to the junction block 20, and the pressure source 50 is disposed on the side of the second liquid supply pipeline 200 close to the buffer container 40, so that the liquid condition on the external liquid storage barrel 10 can be detected quickly, the operation of the pressure source 50 is stopped, and excessive air is prevented from entering the buffer container 40.

In an alternative embodiment, the buffer container 40 is provided with a liquid level detector inside, and the liquid level detector is electrically connected to the pressure source 50, and the liquid level detector can detect the liquid level height of the liquid on the buffer container 40, so that the processor 70 can control the on or off of the pressure source 50 through the liquid level detector.

In general, the level detector may be a conventional pressure sensor for detecting the level of the cleaning fluid in the buffer container 40, and the processor 70 sends a signal to alert a user or control the pressure source 50 to operate or stop operating when the level detector detects that the level of the cleaning fluid in the buffer container 40 is lower or higher than a predetermined value. The cleaning liquid in the buffer container 40 can be detected in real time by adopting the liquid level detector, the cleaning liquid on the external liquid storage barrel 10 can be continuously loaded into the buffer container 40 under the condition that the cleaning liquid in the buffer container 40 is insufficient, and the condition that the sample analysis device cannot continuously work due to the insufficient cleaning liquid in the buffer container 40 is avoided.

In an alternative embodiment, the liquid level detector comprises a first liquid inlet detector 411 and a first liquid stop detector 412, the first liquid inlet detector 411 and the first liquid stop detector 412 are both installed inside the buffer container 40, and when the liquid on the buffer container 40 contacts the position of the first liquid inlet detector 411, the processor 70 controls the pressure source 50 to work and controls the external liquid storage barrel 10 to discharge the liquid to the buffer container 40; when the liquid on the buffer container 40 contacts the position of the first liquid stop detector 412, the processor 70 controls the pressure source 50 to stop working and stops the liquid discharge of the external liquid storage tank 10 to the buffer container 40.

In an alternative embodiment, the liquid level detector further comprises a second liquid inlet detector 413 and a second liquid stop detector 414, wherein the second liquid inlet detector 413 is disposed below the first liquid inlet detector 411, and the second liquid stop detector 414 is disposed above the first liquid stop detector 412; when the liquid on the buffer container 40 contacts the position of the second liquid inlet detector 413, the processor 70 controls the pressure source 50 to work and controls the external liquid storage barrel 10 to discharge the liquid to the buffer container 40; when the liquid on the buffer container 40 contacts the position of the second liquid stop detector 414, the processor 70 controls the pressure source 50 to stop working and suspends the liquid discharge of the external liquid storage bucket 10 to the buffer container 40.

Specifically, the liquid level detector is a four-stage float switch, the four-stage float switch is arranged in the buffer container 40, and the four-stage float is used for detecting the relation between the liquid level height of the cleaning liquid in the buffer container 40 and four heights, wherein the four heights are H1, H2, H3 and H4 respectively. In this embodiment, the H1 height is set at a point above the bottom or bottom of the buffer container 40, the H4 height is set at a point below the top or top of the buffer container 40, the H2 height and the H3 height are set at the middle of the buffer container 40, the H2 height is above the H1 height, and the H3 height is below the H4 height, i.e., H1< H2< H3< H4.

The second liquid inlet detector 413 corresponds to the height H1, the second liquid stop detector 414 corresponds to the height H4, the first liquid inlet detector 411 corresponds to the height H2, the first liquid stop detector 412 corresponds to the height H3, the second liquid inlet detector 413 mainly prevents the first liquid inlet detector 411 from being damaged to cause the shortage of the cleaning liquid in the buffer container 40, and the second liquid stop detector 414 mainly prevents the first liquid stop detector 412 from being damaged to cause the overflow of the cleaning liquid in the buffer container 40.

In an alternative embodiment, as shown in fig. 1 to 5, the buffer container 40 includes a first buffer container 41, wherein the first buffer container 41 is disposed inside the sample analyzer, and the second liquid supply line 200 is used to communicate the first buffer container 41 with the junction block 20 outside the sample analyzer, so as to transfer the liquid on the junction block 20 into the first buffer container 41. Generally, the first buffer container 41 is disposed inside each sample analyzer, so that the external liquid storage barrel 10 converged on the converging block 20 can be connected to the first buffer container 41 through the second liquid supply pipeline 200, and not only is the buffer container 40 not added outside, but also the internal procedure of the sample analyzer is not modified greatly, thereby saving a lot of manpower and material resources.

In an alternative embodiment, as shown in fig. 5, the pressure source 50 and the detection unit 60 are disposed outside the sample analyzer, a third liquid supply line 300 for switching with the second liquid supply line 200 is disposed inside the sample analyzer, and an internal liquid supply assembly is connected to the third liquid supply line 300.

Wherein, the internal liquid supply assembly comprises an internal control valve 31, an internal detection unit 61, an internal pressure source 51 and at least one internal liquid storage barrel 11, the internal control valve 31 is arranged between the internal detection unit 61 and the internal liquid storage barrel 11, and the internal pressure source 51 is arranged between the first buffer container 41 and the internal detection unit 61.

In the present embodiment, the number of the internal liquid storage tanks 11 and the internal control valves 31 is two, the two internal control valves 31 are correspondingly installed between the two internal liquid storage tanks 11 and the internal manifold block 21, the internal detection unit 61 and the internal pressure source 51 are disposed between the internal manifold block 21 and the first buffer container 41, that is, the liquid supply fittings of the internal liquid supply system of the sample analyzer are substantially the same as those of the external liquid supply system of the sample analyzer, when the cleaning liquid on the internal liquid storage tank 11 is consumed, the third liquid supply pipeline 300 on the first buffer container 41 is directly replaced by the second liquid supply pipeline 200, so that the cleaning liquid on the external liquid storage tank 10 can be discharged into the first buffer container 41, and it is ensured that the sample analyzer has enough cleaning liquid to clean the dispensing needle, and thus the sample analyzer can continuously operate.

In an alternative embodiment, as shown in fig. 1 to 4, the pressure source 50 and the detecting unit 60 are disposed inside the sample analyzer to reduce the manufacturing cost of the external liquid supply system, that is, the external liquid storage tank 10 is directly connected to the pressure source 50 and the detecting unit 60 inside the sample analyzer through the second liquid supply pipeline 200 after being converged to the confluence block 20, so that the liquid condition of the external liquid storage tank 10 can be detected by the detecting unit 60, and the cleaning liquid in the external liquid storage tank 10 can be discharged to the first buffer container 41 through the pressure source 50.

Generally, the sample analyzer is configured with a buffer container 40, a pressure source 50, a detection unit 60, an internal control valve 31 and two internal liquid storage barrels 11, wherein the cleaning solutions in the two internal liquid storage barrels 11 are converged to the internal converging block 21 and then discharged to the buffer container 40, and the internal control valve 31 is used for controlling the closing and opening of the two internal liquid storage barrels 11, so that the internal liquid storage barrels 11 can supply the liquid to the buffer container 40 through the pressure source 50. Wherein the internal control valve 31 is disposed between the internal manifold block 21 and the internal liquid storage tank 11, and the detection unit 60 is disposed between the pressure source 50 and the internal manifold block 21.

In an alternative embodiment, as shown in fig. 1, a third liquid supply pipeline 300 is connected between the confluence block 20 and the detection unit 60, and an internal liquid supply assembly is connected to the third liquid supply pipeline 300. In the present embodiment, the internal liquid supply assembly comprises an internal control valve 31 and at least one internal liquid storage barrel 11, when the cleaning liquid in the internal liquid storage barrel 11 is consumed, the internal control valve 31 closes all the third liquid supply pipelines 300 connected to the internal liquid storage barrel 11, and the control valve 30 outside the sample analyzer is opened, so that the pressure source 50 can transfer the cleaning liquid in the external liquid storage barrel 10 to the first buffer container 41, thereby ensuring the continuous operation of the sample analyzer.

In an alternative embodiment, as shown in fig. 2, the junction block 20 can be connected to one of the inner liquid storage barrels 11 inside the sample analyzer through the second liquid supply pipeline 200, so that the integrity of the inner pipeline of the sample analyzer can be ensured without modifying the inner pipeline of the sample analyzer.

In an alternative embodiment, as shown in fig. 3 and 4, the buffer container 40 further includes a second buffer container 42 disposed outside the sample analysis device, and an external pressure source 52 and an external detection unit 62 are disposed on a second liquid supply line between the second buffer container 42 and the confluence block 20. In the present embodiment, the external pressure source 52 is disposed between the external detection unit 62 and the second buffer container 42, and the detection unit 60 is disposed between the pressure source 50 and the second buffer container 42, and since the external pressure source 52, the external detection unit 62, and the second buffer container 42 are disposed outside the sample analyzer, the second buffer container 42 is connected to the internal pipeline of the sample analyzer, so that the internal pipeline of the sample analyzer does not need to be modified, and the control program of the internal pipeline of the sample analyzer does not need to be changed, thereby ensuring the integrity of the internal pipeline and the control program of the sample analyzer, and saving a lot of manpower and material resources.

Specifically, the external pressure source 52 is mainly used for transferring the cleaning liquid on the external liquid storage barrel 10 to the second buffer container 42, and the external detection unit 62 is used for detecting the liquid condition of the cleaning liquid in each external liquid storage barrel 10, so that the control valve 30 can control the opening or closing of the first liquid supply pipeline 100 connected to each external liquid storage barrel 10; the pressure source 50 is mainly used to transfer the cleaning solution in the second buffer container 42 to the first buffer container 41 to ensure the continuous operation of the sample analyzer; the detection unit 60 is mainly used for detecting the liquid condition of the cleaning liquid on the second buffer container 42.

In addition, as shown in fig. 4, the second buffer container 42 can be connected to one of the inner liquid storage barrels 11 of the sample analyzer via the second liquid supply pipeline 200, so that the integrity of the inner pipeline of the sample analyzer can be ensured without modifying the inner pipeline of the sample analyzer.

In an alternative embodiment, as shown in fig. 6, the second buffer containers 42 are provided with communication interfaces 421 for communicating with communication interfaces on another second buffer container 42.

Specifically, as shown in fig. 6, a plurality of second buffer containers 42 may be provided outside the sample analyzer, and each of the second buffer containers 42 may be connected to each other through a connection port 421, so that the liquid may be continuously supplied to the first buffer container 41 inside the sample analyzer, thereby ensuring continuous operation of the sample analyzer. Of course, only one second buffer container 42 may be disposed outside each sample analyzer, and the second buffer containers 42 may be connected to each other through the connection port 421, so that the cleaning solution in the second buffer containers 42 may be used among the plurality of sample analyzers, wherein the external pressure source 52 transfers the cleaning solution in the plurality of external reservoirs 10 to the second buffer containers 42, and the second buffer containers 42 transfer the cleaning solution to the first buffer containers 41 inside one or more sample analyzers, respectively, so that the cleaning module in the sample analyzer may extract the cleaning solution from the first buffer containers 41 to clean the dispensing needles, thereby ensuring continuous operation of the sample analyzers.

After the technical scheme is adopted, because the second buffer container 42 is provided with a plurality of communicating interfaces, when one sample analyzer can simultaneously use the second buffer containers 42 outside other sample analyzers, for example, a biochemical analyzer is currently working, and only one second buffer container 42 outside the biochemical analyzer supplies liquid, but the biochemical analyzer needs more cleaning liquid to complete the current test, at this time, the biochemical analyzer can use the second buffer containers 42 externally arranged on one or more of a blood cell analyzer, a special protein analyzer, a glycated hemoglobin analyzer, an immunoassay analyzer and a blood type analyzer, so as to realize a resource sharing principle, and also ensure that the biochemical analyzer has enough cleaning liquid to clean the dispensing needle on the biochemical analyzer.

Of course, the second buffer container 42 can supply liquid through two external liquid storage barrels 10 or six external liquid storage barrels 10, generally, the number of the external liquid storage barrels 10 configured with the second buffer container 42 is fixed, for example, only six, and at this time, the biochemical analyzer needs the usage amount of eight external liquid storage barrels 10, so that the two second buffer containers 42 can be communicated, so that after the biochemical analyzer uses up the cleaning liquid on one of the second buffer containers 42, the cleaning liquid on the other second buffer container 42 can be used, and the biochemical analyzer can be ensured to work continuously. In an alternative embodiment, as shown in fig. 8 and 9, the space for accommodating the buffer container 40, the pressure source 50 and the detection unit 60 inside the sample analyzer is relatively reduced because the sample analyzer has a more compact structure and a more complete function, and the buffer container 40, the pressure source 50 and the detection unit 60 are all disposed outside the sample analyzer, so as to further alleviate the problem of the compact space inside the sample analyzer. In addition, the buffer container 40 is provided with a communication port 421 for communicating with a communication port 421 on another buffer container 40, so that the sample analyzer can extract the cleaning solution from more buffer containers 40 which are communicated with each other.

In an alternative embodiment, as shown in fig. 10, a plurality of liquid supply ports 422 are provided on the second buffer container 42, and the plurality of liquid supply ports 422 are respectively connected to the cleaning assemblies 400 of the plurality of sample analyzers, i.e. the second buffer container 42 can supply liquid to the plurality of sample analyzers through the liquid supply ports 422.

Specifically, after the external pressure source 52 transfers the cleaning liquid in the plurality of external liquid containers 10 to the second buffer container 42, the second buffer container 42 transfers the cleaning liquid to the first buffer containers 41 in the plurality of sample analyzers, respectively, so that the cleaning module in the sample analyzer can extract the cleaning liquid from the first buffer containers 41 to clean the dispensing needles, thereby ensuring continuous operation of the sample analyzer.

After the technical scheme is adopted, because the second buffer container 42 is provided with the plurality of liquid supply interfaces 422, liquid can be supplied to a plurality of sample analysis devices through one second buffer container 42 at the same time, especially when the laboratory control is insufficient, for example, sample analysis devices such as a biochemical analyzer, a blood cell analyzer, a special protein analyzer, a glycosylated hemoglobin analyzer, an immunity analyzer and a blood type analyzer are placed in a laboratory, and when the internal cleaning liquid of two of the sample analysis devices is insufficient, the two sample analysis devices can be simultaneously connected to the liquid supply interfaces 422 of the second buffer container 42, so that the two sample analysis devices can continuously work. In an alternative embodiment, as shown in fig. 11, as the structure of the sample analyzer is more compact and the function of the sample analyzer is more complete, the space for accommodating the buffer container 40, the pressure source 50 and the detection unit 60 inside the sample analyzer is relatively reduced, and the buffer container 40, the pressure source 50 and the detection unit 60 are all disposed outside the sample analyzer, so as to further alleviate the problem of compact space inside the sample analyzer. Furthermore, the buffer container 40 is provided with a plurality of liquid supply ports, so that the cleaning modules of the plurality of sample analyzers can extract the cleaning liquid from the buffer container 40 through the corresponding liquid supply ports.

In an alternative embodiment, as shown in fig. 1 to 11, the detecting unit 60 includes a bubble detector disposed on the second liquid supply pipeline 200 for acquiring bubble information on the second liquid supply pipeline 200, so that the control valve 30 can determine whether the cleaning liquid on the external liquid storage barrel 10 or the internal liquid storage barrel 11 has been consumed through the acquired bubble information, and accordingly perform a corresponding switch to ensure that the external liquid storage barrel 10 or the internal liquid storage barrel 11 can continuously supply liquid to the buffer container 40.

It should be noted that, the connection between the second liquid supply pipeline 200 and the sample analyzer is performed through the quick connector, so that the liquid supply assembly outside the sample analyzer and the liquid supply assembly inside the sample analyzer can be quickly combined together, the connection is more stable, and the pipelines can be conveniently disassembled and assembled, so that a great amount of manpower and material resources can be saved.

As shown in fig. 6 to 7, a liquid supply system in one embodiment comprises a plurality of sample analyzers and an external liquid supply assembly, wherein the external liquid supply assembly comprises a plurality of external liquid storage tanks 10, a manifold block 20, a first liquid supply pipeline 100, a valve assembly, a buffer container 42 and a second liquid supply pipeline 200. In the present embodiment, the plurality of external reservoirs 10, the manifold block 20, the first fluid supply line 100, the valve assembly, and the buffer container 42 are all disposed outside the sample analyzer, and the second fluid supply line 200 is connected between the manifold block 20 and the buffer container 42.

Specifically, the plurality of external liquid storage tanks 10 are used for storing cleaning liquid; the confluence block 20 is used for pooling the liquids in the plurality of external liquid storage barrels 10; the first liquid supply pipeline 100 is connected between the external liquid storage barrels 10 and the confluence block 20, and is used for conveying the liquid on each external liquid storage barrel 10 into the confluence block 20; the buffer container 42 is used for storing the cleaning liquid transferred from the manifold block 20 so that the sample analyzer can extract the cleaning liquid from the buffer container 42 to clean the dispensing needle; the second liquid supply pipeline 200 is provided with an external pressure source 52 and an external detection unit 62, the external pressure source 52 is arranged between the external detection unit 62 and the buffer container 40, the external pressure source 52 is used for generating the pressure of the external liquid storage barrel 10 for discharging liquid to the buffer container 42, and the external detection unit 62 is used for detecting the liquid condition on each external liquid storage barrel 10, so that when the external liquid storage barrel 10 discharges liquid to the buffer container 42, the valve assembly can be switched according to the liquid condition on each external liquid storage barrel 10.

In the present embodiment, each of the buffer containers 42 is provided with a communication port 421 for communicating with a buffer container on another external liquid supply assembly, so that a plurality of sample analyzers can mutually supply liquid by using the respective buffer containers 42.

As shown in FIG. 9, an embodiment of a liquid supply system includes an external liquid supply assembly and a plurality of sample analyzing devices; the external liquid supply assembly includes a plurality of external liquid storage tanks 10, a manifold block 20, a first liquid supply pipeline 100, a valve assembly, a buffer container 42, and a second liquid supply pipeline 200. In the present embodiment, the plurality of external reservoirs 10, the manifold block 20, the first fluid supply line 100, the valve assembly, and the buffer container 42 are all disposed outside the sample analyzer, and the second fluid supply line 200 is connected between the manifold block 20 and the buffer container 42.

In this embodiment, the buffer container 42 is provided with a plurality of liquid supply ports 422, and the plurality of liquid supply ports 422 are connected to the plurality of cleaning modules 400 of the sample analyzers, respectively, so that the plurality of cleaning modules 400 of the sample analyzers can supply liquid through one buffer container 42.

Referring to fig. 12, a schematic diagram of a liquid supply system supplying two sample analyzers, in some embodiments, a liquid supply structure inside any one of the sample analyzers is as follows: one or more internal liquid storage barrels 11, two internal liquid storage barrels 11 are shown in the figure, an internal control valve 31 is arranged on a connecting pipeline of the internal liquid storage barrels 11 and a three-way pipe, and an internal detection unit 61 and an internal pressure source 51 are arranged on a connecting pipeline of the three-way pipe and the first buffer container 41. The plurality of external liquid storage tanks 10 share the second buffer container 42, the external detection unit 62 and the external pressure source 52 are provided between the second buffer container 42 and the manifold block 20, the second buffer container 42 communicates with each of the first buffer containers 41 so that external liquid supply is possible, that is, the second buffer container 42 can supply liquid to each of the first buffer containers 41, and the external control valve 30 or the internal control valve 31 may be provided on a pipe connected between the second buffer container 42 and each of the first buffer containers 41. Specifically, when the external liquid supply is required, the processor 70 may select one of the external liquid storage barrels 10 for liquid supply, i.e., the external control valve 30 connected to the external reservoir 10 is opened, the external pressure source 52 is operated, so that the external liquid storage tank 10 supplies the second buffer container 42 with the liquid, and the sample analysis device can take the cleaning liquid from the second buffer container 42, specifically, the internal control valve 31 between the second buffer container 42 and the first buffer container 41 of the sample analyzer to be supplied with liquid may be opened, so that the second buffer container 42 supplies the liquid to the first buffer container 41 of the corresponding sample analysis device, the cleaning assembly 400 corresponding to the sample analyzer is then used to obtain the cleaning solution from the corresponding first buffer container 41, and it should be noted that, during this external supply, the internal control valves 31 associated with each internal reservoir 11 are closed. When the sample analyzer needs to perform internal liquid supply, the internal control valve 31 connected to the currently supplied internal liquid storage tank 11 is opened, and the internal pressure source 51 operates, so that the internal liquid storage tank 11 supplies liquid to the first buffer container 42, and when the first buffer container 42 buffers the cleaning liquid, the cleaning assembly 400 of the sample analyzer can obtain the cleaning liquid from the first buffer container 42. In contrast to the liquid supply system disclosed in FIG. 12, the liquid supply system disclosed in FIG. 13 is configured to connect the internal reservoir 11 of a sample analyzer to the cleaning assembly 400 thereof, and to connect the external reservoir 10 to the cleaning assemblies 400 of various sample analyzers, as well as to connect the internal reservoir 11 of a sample analyzer to the cleaning assembly 400 of another sample analyzer. With the structure of fig. 13, the liquid can be supplied from the internal liquid storage tank 11 of one sample analyzer to another sample analyzer.

The processor 70 of the liquid supply system in this embodiment may be configured to control the external liquid supply to the sample analyzer according to the load status of each sample analyzer when the external liquid supply is activated.

It will be appreciated that the opportunity to activate external liquid supply may vary for different liquid supply strategies. If the liquid supply strategy is to preferentially use the built-in cleaning liquid, when the cleaning liquid in the built-in liquid storage barrel of the sample analysis device is exhausted, external liquid supply is started; and if the liquid supply strategy is to preferentially use the external cleaning liquid, the liquid supply system starts external liquid supply when being connected with the sample analysis device.

In the liquid supply system provided by the embodiment, the external liquid storage barrel 10 arranged outside the sample analysis device provides the cleaning liquid, so that the replacement frequency of the internal liquid storage barrel 11 is reduced, the on-machine test number supported by the cleaning liquid is increased, and the sample analysis device can continuously perform the test for a long time; the buffer container of the liquid supply system is respectively connected with the cleaning assemblies on the plurality of sample analysis devices, so that liquid can be supplied to the plurality of sample analysis devices from the outside; when the liquid supply system supplies liquid to the plurality of sample analysis devices, the liquid supply system controls the sample analysis devices to supply liquid externally according to the load state of each sample analysis device, so that self-adaptive liquid supply is realized, and user interaction in the liquid supply process is reduced.

The above embodiments describe the structure of the liquid supply system provided by the present application, and how the liquid supply system provided by the present application realizes adaptive liquid supply according to the load status of each sample analyzer will be described in the following by several embodiments.

In one embodiment, the processor 70 controls the external liquid supply to the sample analyzer according to the load status of each sample analyzer, and may specifically include:

when some sample analyzers are in the testing state and some sample analyzers are in the idle state, the processor 70 controls to reserve a preset number of external liquid storage barrels 10 for each idle sample analyzer, and allocates the remaining external liquid storage barrels 10 to supply liquid to the sample analyzers in the testing state. By reserving a preset number of external liquid storage barrels 10 for the sample analysis device in an idle state, it can be ensured that sufficient cleaning liquid is available for use when the sample analysis device in the idle state is started for testing. Further, in order to make the reservation more reasonable, not only can it be ensured that the sample analyzer in the idle state has sufficient cleaning solution available when starting the test, but also it can be ensured to supply the liquid to the sample analyzer currently in the test state to the maximum extent, the processor 70 may obtain the historical liquid consumption data of each analyzer, so as to calculate the preset number corresponding to each analyzer. The processor 70 reserves the external liquid storage tanks according to the calculated preset number corresponding to the idle-state sample analysis device.

When the external liquid storage barrel 10 allocated to the sample analysis device in the test state is judged to be in an empty state, the processor controls the external liquid storage barrel 10 reserved for the sample analysis device in the idle state to supply liquid to the sample analysis device in the test state, and the smooth test of the sample analysis device in the test state can be preferentially ensured.

The processor 70 may further set the external liquid storage tank 10 reserved for the sample analyzer in an idle state to a releasable state or a non-releasable state, where the external liquid storage tank reserved for a certain sample analyzer may be used for supplying liquid to other sample analyzers in some cases, and the non-releasable state is where the external liquid storage tank reserved for a certain sample analyzer is not used for supplying liquid to other sample analyzers. The processor 70 may set the state of the reserved external cartridge according to, for example, the degree of importance of the test item of the sample analysis apparatus in the idle state or the input of the user. For example, if the user determines that the sample analyzer M is always to start testing the sample in a certain testing period, but the time for starting the test of the sample analyzer M is later, the sample analyzer M is still in an idle state when other sample analyzers are in the testing state, and in order to ensure that the sample analyzer M has sufficient cleaning solution to be supplied when starting the test, the user may perform relevant operations on a state setting interface, for example, so that the processor sets the external tank reserved for the sample analyzer M that is currently in the idle state to an unreleasable state.

The processor 70 controls the external liquid storage barrel 10 reserved for the sample analysis device in the idle state, and before the liquid supply is performed on the sample analysis device in the test state, the processor 70 also judges whether the external liquid storage barrel 10 reserved for the sample analysis device in the idle state is set to be in the releasable state; if so, the processor 70 controls the external liquid storage barrel 10 reserved for the sample analyzer in the idle state to supply liquid to the sample analyzer in the test state.

Taking the example of the liquid supply system supplying liquid externally to the two sample analyzers M1 and M2, it is assumed that the liquid supply system has 6 external liquid storage tanks 10. When M1 is in a testing state and M2 is in an idle state, if processor 70 calculates that the preset number of M2 is 1 according to the historical liquid consumption data of M2, processor 70 controls to reserve 1 bucket for M2 and allocate the remaining 5 buckets to supply liquid for M1. Specifically, if the serial numbers of the 6 external liquid storage barrels are 1-6, the liquid storage barrel number 6 can be reserved for the M2 in the idle state, and the liquid storage barrel number 1-5 can be allocated to the M1 in the test state for liquid supply. When all the external liquid storage barrels 10 1-5 allocated to the M1 are exhausted and in an empty state, if the M2 is still in an idle state and the liquid storage barrel 6 reserved for the M2 is set to be in a releasable state, the processor 70 controls the external liquid storage barrel 6 reserved for the M2 to supply liquid to the M1 in a test state, and the smooth progress of the currently executed test items is preferentially ensured.

In one embodiment, the processor 70 controls the external liquid supply to the sample analyzer according to the load status of each sample analyzer, and may specifically include: each sample analysis device is provided with a corresponding external liquid storage barrel 10 in advance; the processor 70 controls the corresponding external liquid storage bucket to supply liquid to the corresponding sample analysis device in the test state. The processor 70 may set a corresponding external liquid storage tank for each kind of the analysis apparatus according to the historical liquid consumption data of each kind of the analysis apparatus.

When the external liquid storage barrel 10 corresponding to the sample analyzer in the testing state is in an empty state, the processor 70 controls the external liquid storage barrel corresponding to the sample analyzer in the idle state to supply liquid to the sample analyzer in the testing state, so as to preferentially ensure that the currently executed testing item is smoothly performed.

In an alternative embodiment, the processor 70 controls the external liquid storage barrel corresponding to the sample analyzer in the idle state, and before the liquid supply is performed on the sample analyzer in the test state, the processor 70 further determines whether the external liquid storage barrel 10 corresponding to the sample analyzer in the idle state is set to the releasable state; if yes, the processor 70 controls the external liquid storage barrel 10 corresponding to the sample analyzer in the idle state to supply liquid to the sample analyzer in the test state.

Still taking the example of the liquid supply system supplying liquid externally to the two sample analyzers M1 and M2, it is assumed that the liquid supply system has 6 external liquid tanks numbered 1-6. The processor 70 sets the barrels 1-4 as the external liquid storage barrel 10 corresponding to the sample analysis device M1 and sets the barrels 5-6 as the external liquid storage barrel 10 corresponding to the sample analysis device M2 according to the historical liquid consumption data of M1 and M2. When M1 is in the testing state and M2 is in the idle state, the processor controls external liquid storage tank 10 No. 1-4 to supply liquid to corresponding sample analyzer M1 in the testing state. With the progress of the test, when the external liquid storage barrel No. 1-4 corresponding to the sample analyzer M1 in the test state is empty, the sample analyzer M2 is still in the idle state and the corresponding external liquid storage barrels No. 5 and No. 6 are set to be in the releasable state, the processor controls the external liquid storage barrel No. 5 or No. 6 corresponding to the sample analyzer M2 in the idle state to supply liquid to the sample analyzer M1 in the test state.

In one embodiment, the processor 70 controls the external liquid supply to the sample analyzer according to the load status of each sample analyzer, and may specifically include: when the remaining liquid amounts of the external liquid storage barrels 10 are judged to be insufficient to support the sample analysis devices in the test states, the processor 70 supplies liquid to the sample analysis devices in the test states according to the priorities of the sample analysis devices, and adaptive liquid supply with the sample analysis devices as units is realized. The processor 70 in this embodiment may determine the priority of the sample analysis device based on the sample priority and/or the item priority. The processor 70 supplies the liquid to each sample analyzer in the test state according to the priority of the sample analyzer, and specifically includes: the processor 70 controls the external liquid storage barrel to preferentially supply liquid to the sample analysis device with high priority, so that the normal operation of the sample analysis device with high priority can be preferentially ensured when the residual amount of the cleaning liquid is insufficient.

In an alternative embodiment, the determining, by the processor 70, the priority of the sample analysis device according to the sample priority may specifically include: the more samples of the sample analysis device that are of high sample priority, the higher the priority of the sample analysis device.

In clinical examination, in order to distinguish the priority degrees of different samples, the samples can be identified by setting sample priorities, for example, the sample priorities can be classified into three levels of high, medium and low according to the types of the samples, specifically, the sample priority of an emergency patient sample can be set to be high, the sample priority of an ordinary patient sample can be set to be medium, and the sample priority of a sample physical examination can be set to be low. Typically, the higher the sample priority, the shorter the required sample turnaround time.

For example, five sample analyzers, T1, T2, T3, T4 and T5, are connected to the liquid supply system, and currently, 3 sample analyzers, T1, T2 and T5, are in a test state. The number of high sample priorities in the sample analyzers T1, T2, and T5 is 15, 20, and 40, respectively, and the sample analyzer T5 has the highest priority. When the residual liquid amounts of the plurality of external liquid storage barrels of the liquid supply system are judged to be insufficient to support the sample analysis devices T1, T2 and T5 which are currently in the test state, the processor controls the external liquid storage barrels to preferentially supply liquid to the T5. Because the samples with high sample priority in the T5 are the most, the liquid is preferentially supplied to the T5, and the test can be successfully completed by the samples with high sample priority as much as possible under the condition that the residual quantity of the cleaning liquid is insufficient.

In an alternative embodiment, the processor 70 determines the priority of the sample analyzer according to the item priority, which may specifically include: the more items of the sample analyzer having a high item priority, the higher the priority of the sample analyzer.

In clinical examination, in order to distinguish the priority degrees of different test items, the items can be identified by setting item priority levels, the higher the number is, the lower the item priority level is, and the lower the number is, the higher the item priority level is, the higher the myocardial item priority level is, which is 1; the priority of the four items before the operation is 2; HCG and PCT again have a priority of 3. The higher the priority of the sample analyzer, the more test items Tn there are in the sample analyzer.

In an alternative embodiment, the processor 70 determines the priority of the sample analyzer according to the item priority, which may specifically include: the more items in the preset set of items in the sample analysis device, the higher the priority of the sample analysis device. The preset item set may include test items with medical implications, where the TAT time of the test items is related to the life of the patient, and the TAT time of the test items is more urgent for the sample.

when the remaining liquid amounts of the plurality of external liquid storage barrels 10 are judged to be insufficient to support the sample analyzers currently in the test states, the processor 70 supplies liquid to the sample analyzers currently in the test states according to the sample-related priorities.

In an alternative embodiment, the processor 70 supplies the sample analyzer under test according to the sample-related priority, including: the sample correlation priority comprises a sample priority; the processor 70 controls the external liquid storage barrel 10 to preferentially supply liquid to the items of the high-priority samples in the sample analysis device in the test state, so that the self-adaptive liquid supply by taking the samples as units is realized.

In an alternative embodiment, the processor 70 supplies the sample analyzer under test according to the sample-related priority, including: the sample related priorities include item priorities; the processor 70 controls the external liquid storage barrel to preferentially supply liquid to the items with high priority in each sample analysis device in the test state, so that self-adaptive liquid supply with the test items as units is realized.

FIG. 14 is a flow diagram of a method of a liquid supply system according to an embodiment that may be used in a liquid supply system for externally supplying liquid to one or more sample analyzers, and that may include a plurality of external reservoirs disposed external to the sample analyzers for storing cleaning liquid. As shown in fig. 14, the method may include:

and step 101, acquiring the load states of various analysis devices when external liquid supply is started.

And 102, controlling external liquid supply to the sample analysis devices according to the load states of the sample analysis devices.

In some embodiments, the step 102 of controlling the external liquid supply to the sample analyzer according to the load status of each sample analyzer comprises: when part of the sample analysis devices are in a test state and part of the sample analysis devices are in an idle state, step 102 controls to reserve a preset number of external liquid storage barrels for each idle-state sample analysis device, and distributes the rest external liquid storage barrels to supply liquid to the sample analysis devices in the test state. Through reserving the outside stock solution bucket of presetting quantity to the sample analysis device who is in idle state, can ensure that the sample analysis device of idle state has sufficient washing liquid to supply when starting the test and use. Further, in order to make the reservation more reasonable, not only can it be ensured that the sample analysis device in the idle state has sufficient cleaning solution available when starting the test, but also the liquid supply to the sample analysis device currently in the test state can be ensured to the maximum extent, step 102 may obtain the historical liquid consumption data of each analysis device, so as to calculate the preset number corresponding to each analysis device. Step 102, reserving external liquid storage barrels according to the calculated preset number corresponding to the sample analysis devices in the idle state.

When the external liquid storage barrel allocated to the sample analysis device in the test state is determined to be in an empty state, step 102 controls the external liquid storage barrel reserved for the sample analysis device in the idle state to supply liquid to the sample analysis device in the test state, so that the smooth test of the sample analysis device in the test state can be preferentially ensured.

Step 102 may also set the external liquid storage barrel reserved for the sample analyzer in an idle state to a releasable state or a non-releasable state, where the releasable state is that the external liquid storage barrel reserved for a certain sample analyzer may be used to supply liquid to other sample analyzers in some cases, and the non-releasable state is that the external liquid storage barrel reserved for a certain sample analyzer may not be used to supply liquid to other sample analyzers. Step 102 may set the state of the reserved external reservoir, for example, according to the importance of the test item of the sample analysis apparatus in an idle state or an input of a user. For example, if the user determines that the sample analyzer M is always to start testing the sample in a certain testing period, but the time for starting the test of the sample analyzer M is later, the sample analyzer M is still in an idle state when other sample analyzers are in the testing state, and in order to ensure that the sample analyzer M has sufficient cleaning solution to be supplied when starting the test, the user may perform relevant operations on a state setting interface, for example, so that the processor sets the external tank reserved for the sample analyzer M that is currently in the idle state to an unreleasable state.

Controlling the external liquid storage barrel 10 reserved for the sample analysis device in the idle state, and before liquid supply is carried out on the sample analysis device in the test state, step 102 also judges whether the external liquid storage barrel reserved for the sample analysis device in the idle state is set to be in a releasable state; if yes, step 102 controls an external liquid storage barrel reserved for the sample analysis device in an idle state to supply liquid to the sample analysis device in a test state.

In one embodiment, the step 102 of controlling the external liquid supply to the sample analyzer according to the load status of each sample analyzer may specifically include: each sample analysis device is provided with a corresponding external liquid storage barrel in advance; step 102 controls the corresponding external liquid storage barrel to supply liquid to the corresponding sample analysis device in the test state. Step 102 may set a corresponding external liquid storage barrel for each analysis device according to the historical liquid consumption data of each analysis device.

When the external liquid storage barrel corresponding to the sample analysis device in the testing state is in an empty state, step 102 controls the external liquid storage barrel corresponding to the sample analysis device in the idle state to supply liquid to the sample analysis device in the testing state, so as to preferentially ensure that the currently executed testing project is smoothly performed.

In an alternative embodiment, the external liquid storage barrel corresponding to the sample analyzer in the idle state is controlled, and before the liquid is supplied to the sample analyzer in the test state, step 102 further determines whether the external liquid storage barrel corresponding to the sample analyzer in the idle state is set to the releasable state; if yes, step 102 controls the external liquid storage barrel corresponding to the sample analysis device in the idle state to supply liquid to the sample analysis device in the test state.

Still taking the example of the liquid supply system supplying liquid externally to the two sample analyzers M1 and M2, it is assumed that the liquid supply system has 6 external liquid tanks numbered 1-6. The processor 70 sets the barrels 1-4 as the external liquid storage barrel 10 corresponding to the sample analysis device M1 and sets the barrels 5-6 as the external liquid storage barrel 10 corresponding to the sample analysis device M2 according to the historical liquid consumption data of M1 and M2. When M1 is in the testing state and M2 is in the idle state, processor 70 controls external liquid storage tank 10 No. 1-4 to supply liquid to corresponding sample analyzer M1 in the testing state. With the progress of the test, when the external liquid storage tank 10 No. 1-4 corresponding to the sample analyzer M1 in the test state is empty, the sample analyzer M2 is still in the idle state, and the corresponding external liquid storage tanks No. 5 and No. 6 are set to be in the releasable state, the processor 70 controls the external liquid storage tank 10 No. 5 or No. 6 corresponding to the sample analyzer M2 in the idle state to supply liquid to the sample analyzer M1 in the test state.

In one embodiment, the step 102 of controlling the external liquid supply to the sample analyzer according to the load status of each sample analyzer may specifically include: when the residual liquid amounts of the external liquid storage barrels are judged to be insufficient to support the sample analysis devices in the test states, step 102 supplies liquid to the sample analysis devices in the test states according to the priorities of the sample analysis devices, and adaptive liquid supply with the sample analysis devices as units is achieved. Step 102 in this embodiment may determine the priority of the sample analysis device based on the sample priority and/or the item priority. Step 102 of supplying liquid to each sample analyzer in a test state according to the priority of the sample analyzer may specifically include: and 102, controlling the external liquid storage barrel to preferentially supply liquid to the sample analysis device with high priority so as to preferentially ensure the normal operation of the sample analysis device with high priority when the residual quantity of the cleaning liquid is insufficient.

In an optional implementation manner, the step 102 of determining the priority of the sample analysis device according to the sample priority may specifically include: the more samples of the sample analysis device that are of high sample priority, the higher the priority of the sample analysis device.

For example, five sample analyzers, T1, T2, T3, T4 and T5, are connected to the liquid supply system, and currently, 3 sample analyzers, T1, T2 and T5, are in a test state. The number of high sample priorities in the sample analyzers T1, T2, and T5 is 15, 20, and 40, respectively, and the sample analyzer T5 has the highest priority. When the residual liquid amounts of the plurality of external liquid storage barrels of the liquid supply system are judged to be insufficient to support the sample analysis devices T1, T2 and T5 which are currently in the test state, the processor 70 controls the external liquid storage barrels to preferentially supply liquid to the T5. Because the samples with high sample priority in the T5 are the most, the liquid is preferentially supplied to the T5, and the test can be successfully completed by the samples with high sample priority as much as possible under the condition that the residual quantity of the cleaning liquid is insufficient.

In an optional implementation manner, the step 102 of determining the priority of the sample analysis device according to the item priority may specifically include: the more items of the sample analyzer having a high item priority, the higher the priority of the sample analyzer.

In clinical examination, in order to distinguish the priority degrees of different test items, the items can be identified by setting item priority levels, the higher the number is, the lower the item priority level is, and the lower the number is, the higher the item priority level is, for example, the description is given, and the test item Tn has the highest priority level, which is 1; the priority rank of the test item Na, the test item K, the test item Cl and the test item Glu is 2; the priority of test item ALT, test item TP, and test item UREA, again, is 3. The higher the priority of the sample analyzer, the more test items Tn there are in the sample analyzer.

In an optional implementation manner, the step 102 of determining the priority of the sample analysis device according to the item priority may specifically include: the more items in the preset set of items in the sample analysis device, the higher the priority of the sample analysis device. The preset item set may include test items with medical implications, where the TAT time of the test items is related to the life of the patient, and the TAT time of the test items is more urgent for the sample.

In one embodiment, the step 102 of controlling the external liquid supply to the sample analyzer according to the load status of each sample analyzer may specifically include:

when the remaining liquid amounts of the external liquid storage barrels are judged to be insufficient to support the sample analysis devices in the test states, step 102 is to supply liquid to the sample analysis devices in the test states according to the sample related priorities.

In an alternative embodiment, step 102 of feeding each sample analyzer in a test state according to a sample-related priority includes: the sample correlation priority comprises a sample priority; step 102 controls the external liquid storage barrel to preferentially supply liquid to items of high-priority samples in the sample analysis device in the test state, and self-adaptive liquid supply with the samples as units is realized.

In an alternative embodiment, step 102 of feeding each sample analyzer in a test state according to a sample-related priority includes: the sample related priorities include item priorities; the processor 70 controls the external liquid storage barrel to preferentially supply liquid to the items with high priority in each sample analysis device in the test state, so that self-adaptive liquid supply with the test items as units is realized.

Reference is made herein to various exemplary embodiments. However, those skilled in the art will recognize that changes and modifications may be made to the exemplary embodiments without departing from the scope hereof. For example, the various operational steps, as well as the components used to perform the operational steps, may be implemented in differing ways depending upon the particular application or consideration of any number of cost functions associated with operation of the system (e.g., one or more steps may be deleted, modified or incorporated into other steps).

In the above embodiments, the implementation may be wholly or partially realized by software, hardware, firmware, or any combination thereof. Additionally, as will be appreciated by one skilled in the art, the principles herein may be reflected in a computer program product on a computer readable storage medium, which is pre-loaded with computer readable program code. Any tangible, non-transitory computer-readable storage medium may be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices (CD-to-ROM, DVD, Blu-Ray discs, etc.), flash memory, and/or the like. These computer program instructions may be loaded onto a general purpose computer, special purpose computer, or other programmable data processing apparatus to produce a machine, such that the instructions which execute on the computer or other programmable data processing apparatus create means for implementing the functions specified. These computer program instructions may also be stored in a computer-readable memory that can direct a computer or other programmable data processing apparatus to function in a particular manner, such that the instructions stored in the computer-readable memory produce an article of manufacture including means for implementing the function specified. The computer program instructions may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified.

While the principles herein have been illustrated in various embodiments, many modifications of structure, arrangement, proportions, elements, materials, and components particularly adapted to specific environments and operative requirements may be employed without departing from the principles and scope of the present disclosure. The above modifications and other changes or modifications are intended to be included within the scope of this document.

The foregoing detailed description has been described with reference to various embodiments. However, one skilled in the art will recognize that various modifications and changes may be made without departing from the scope of the present disclosure. Accordingly, the disclosure is to be considered in an illustrative and not a restrictive sense, and all such modifications are intended to be included within the scope thereof. Also, advantages, other advantages, and solutions to problems have been described above with regard to various embodiments. However, the benefits, advantages, solutions to problems, and any element(s) that may cause any element(s) to occur or become more pronounced are not to be construed as a critical, required, or essential feature or element of any or all the claims. As used herein, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, system, article, or apparatus. Furthermore, the term "coupled," and any other variation thereof, as used herein, refers to a physical connection, an electrical connection, a magnetic connection, an optical connection, a communicative connection, a functional connection, and/or any other connection.

Those skilled in the art will recognize that many changes may be made to the details of the above-described embodiments without departing from the underlying principles of the invention. Accordingly, the scope of the invention should be determined only by the claims.

Claims

1. A liquid supply system, comprising:

a valve assembly disposed outside the sample analysis device, the valve assembly disposed on the first liquid supply line for controlling liquid flow between each of the external reservoirs and the manifold block;

a buffer container for storing the cleaning solution transferred from the confluence block so that the sample analyzer can extract the cleaning solution from the buffer container to clean the dispensing needle; wherein the buffer containers are respectively connected with a plurality of cleaning components on the sample analysis device;

the second liquid supply pipeline is connected between the confluence block and the buffer container, a pressure source and a detection unit are arranged on the second liquid supply pipeline, the pressure source is arranged between the detection unit and the buffer container, the pressure source is used for generating the pressure of the external liquid storage barrels for discharging liquid to the buffer container, and the detection unit is used for detecting the liquid condition on each external liquid storage barrel, so that when the external liquid storage barrels discharge liquid to the buffer container, the valve assembly can be switched according to the liquid condition on each external liquid storage barrel;

2. The liquid supply system of claim 1, wherein the processor controls the external liquid supply to the sample analyzer based on a load state of the sample analyzer, comprising:

when part of the sample analysis devices are in a test state and part of the sample analysis devices are in an idle state, the processor controls to reserve a preset number of external liquid storage barrels for each idle-state sample analysis device, and distributes the rest external liquid storage barrels to supply liquid to the sample analysis devices in the test state.

3. The liquid supply system of claim 2, wherein the processor controls the external liquid supply to the sample analyzer based on a load state of the sample analyzer, further comprising:

4. The liquid supply system of claim 3, wherein the processor controls the external liquid supply to the sample analyzer based on a load state of the sample analyzer, further comprising:

the processor controls an external liquid storage barrel reserved for the sample analysis device in the idle state, and before liquid is supplied to the sample analysis device in the test state, the processor also judges whether the external liquid storage barrel reserved for the sample analysis device in the idle state is set to be in a releasable state;

5. The liquid supply system of claim 2, wherein the processor obtains historical liquid consumption data for each analysis device to calculate the predetermined number for each analysis device.

6. The liquid supply system of claim 1, wherein the processor controls the external liquid supply to the sample analyzer based on a load state of the sample analyzer, comprising:

7. The liquid supply system of claim 6, wherein the processor controls the external liquid supply to the sample analyzer based on a load state of the sample analyzer, further comprising:

8. The liquid supply system of claim 7, wherein the processor controls the external liquid supply to the sample analyzer based on a load state of the sample analyzer, further comprising:

9. The liquid supply system of claim 1, wherein the processor controls the external liquid supply to the sample analyzer based on a load state of the sample analyzer, comprising:

10. The liquid supply system of claim 9, wherein the processor prioritizes the sample analysis devices based on sample priority.

11. The liquid supply system of claim 10, wherein the processor prioritizes the sample analysis devices based on sample priorities, comprising: the more samples of the sample analysis device that are of high sample priority, the higher the priority of the sample analysis device.

12. The liquid supply system of claim 9, wherein the processor prioritizes the sample analysis devices according to project priorities.

13. The liquid supply system of claim 12, wherein the processor prioritizes the sample analysis devices according to project priorities, comprising: the more items of the sample analyzer having a high item priority, the higher the priority of the sample analyzer.

14. The liquid supply system of claim 12, wherein the processor prioritizes the sample analysis devices according to project priorities, comprising: the more items in the preset set of items in the sample analysis device, the higher the priority of the sample analysis device.

15. The liquid supply system according to any one of claims 9 to 14, wherein the processor supplies the liquid to each sample analyzer in the test state according to a priority of the sample analyzer, comprising:

16. The liquid supply system of claim 1, wherein the processor controls the external liquid supply to the sample analyzer based on a load state of the sample analyzer, comprising:

17. The liquid supply system of claim 16, wherein the processor supplies liquid to each sample analyzer in a test state according to a sample-related priority, comprising:

the sample correlation priority comprises a sample priority;

18. The liquid supply system of claim 16, wherein the processor supplies liquid to each sample analyzer in a test state according to a sample-related priority, comprising:

the sample related priorities comprise item priorities;

and the processor controls the external liquid storage barrel to preferentially supply liquid to the high-priority items in the sample analysis device in the test state.

19. A method of a liquid supply system for externally supplying liquid to a plurality of sample analysis devices; the liquid supply system comprises a plurality of external liquid storage barrels, and the external liquid storage barrels are arranged outside the sample analysis device and used for storing cleaning liquid; the method comprises the following steps:

20. The method of claim 19, wherein controlling the external liquid supply to the sample analysis devices based on the load status of each sample analysis device comprises:

21. The method of claim 20, wherein controlling the external liquid supply to the sample analysis devices based on the load status of each sample analysis device further comprises:

22. The method of claim 21, wherein controlling the external liquid supply to the sample analysis devices based on the load status of each sample analysis device further comprises:

23. The method of claim 20, wherein historical fluid consumption data for each analysis device is obtained to calculate the predetermined number for each analysis device.

24. The method of claim 19, wherein controlling the external liquid supply to the sample analysis devices based on the load status of each sample analysis device comprises:

25. The method of claim 24, wherein controlling the external liquid supply to the sample analysis devices based on the load status of each sample analysis device further comprises:

26. The method of claim 25, wherein controlling the external liquid supply to the sample analyzer based on a load condition of the sample analyzer further comprises:

27. The method of claim 19, wherein controlling the external liquid supply to the sample analysis devices based on the load status of each sample analysis device comprises:

28. The method of claim 27, wherein the more samples of the sample analysis device that are of high sample priority, the higher the priority of the sample analysis device.

29. The method of claim 27, wherein the sample analysis device is prioritized according to item priority.

30. The method of claim 29, wherein said prioritizing the sample analysis devices according to item priority comprises: the more items of the sample analyzer having a high item priority, the higher the priority of the sample analyzer.

31. The method of claim 29, wherein said prioritizing the sample analysis devices according to item priority comprises: the more items in the preset set of items in the sample analysis device, the higher the priority of the sample analysis device.

32. The method of claim 19, wherein controlling the external liquid supply to the sample analysis devices based on the load status of each sample analysis device comprises:

33. The method of claim 32, wherein said feeding each sample analysis device in a test state according to a sample associated priority comprises:

the sample correlation priority comprises a sample priority;

34. The method of claim 32, wherein said feeding each sample analysis device in a test state according to a sample associated priority comprises:

the sample related priorities comprise item priorities;

35. A computer-readable storage medium, characterized by comprising a program executable by a processor to implement the method of any one of claims 19 to 34.